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Conserved domains on  [gi|1054820927|ref|WP_066583494|]
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helix-turn-helix domain-containing protein [Cellulomonas timonensis]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-106 1.43e-18

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 74.52  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054820927  10 ALARAFGLLGKRWNGVILGCLADGSLGYSALRRAV-GVSDSVLAARLAELAAAGVVARDVDAGPPVSVRYSLTASGQALV 88
Cdd:COG1733    11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                          90
                  ....*....|....*...
gi 1054820927  89 PGLRELSRWAKAYLPDPG 106
Cdd:COG1733    91 PVLDALAEWGEEHLPEIE 108
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-106 1.43e-18

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 74.52  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054820927  10 ALARAFGLLGKRWNGVILGCLADGSLGYSALRRAV-GVSDSVLAARLAELAAAGVVARDVDAGPPVSVRYSLTASGQALV 88
Cdd:COG1733    11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                          90
                  ....*....|....*...
gi 1054820927  89 PGLRELSRWAKAYLPDPG 106
Cdd:COG1733    91 PVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-103 4.07e-14

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 62.70  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054820927  17 LLGKRWNGVILGCLADGSLGYSALRRAV-GVSDSVLAARLAELAAAGVVARDVDAGPPVSVRYSLTASGQALVPGLRELS 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIpGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 1054820927  96 RWAKAYLP 103
Cdd:pfam01638  81 DWGEEYLE 88
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
10-106 1.43e-18

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 74.52  E-value: 1.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054820927  10 ALARAFGLLGKRWNGVILGCLADGSLGYSALRRAV-GVSDSVLAARLAELAAAGVVARDVDAGPPVSVRYSLTASGQALV 88
Cdd:COG1733    11 PVRRALDVIGGKWKLLILRALLDGPRRFGELRRSLpGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYSLTEKGRSLL 90

                          90
                  ....*....|....*...
gi 1054820927  89 PGLRELSRWAKAYLPDPG 106
Cdd:COG1733    91 PVLDALAEWGEEHLPEIE 108
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 17-103 4.07e-14

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 62.70  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1054820927  17 LLGKRWNGVILGCLADGSLGYSALRRAV-GVSDSVLAARLAELAAAGVVARDVDAGPPVSVRYSLTASGQALVPGLRELS 95
Cdd:pfam01638   1 LIGGKWKGLILRELLDGKKRFSELKRAIpGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELC 80


                  ....*...
gi 1054820927  96 RWAKAYLP 103
Cdd:pfam01638  81 DWGEEYLE 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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