|
Name |
Accession |
Description |
Interval |
E-value |
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
423-874 |
9.54e-100 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 320.19 E-value: 9.54e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 423 RRLPVLLDITVIPDAEGRPLHRLTIVLNISERKRIQRDLESAQIQALQQQKEARLAILNQMQDANAARIKAETALAALSD 502
Cdd:COG4251 60 ALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEE 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 503 SEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEEWL 582
Cdd:COG4251 140 LALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 583 TFAETGYRGLfqtvkvpVFNVDGDVVGVLGIARDITALRQAEEDLRAINTGLEARVVERTAELDILNKSLESFVYSVSHD 662
Cdd:COG4251 220 SLGGGLGLLL-------LLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSNEELEQFAYVASHD 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 663 LKAPLRGIEGYSQLLQEDYATALDDDGRLFIANIRNGVMCMGELIDDLLAYSRMERRKLDSNKLDLALMINQLLAEKADD 742
Cdd:COG4251 293 LREPLRKISGFSQLLEEDYGDKLDEEGREYLERIRDAAERMQALIDDLLAYSRVGRQELEFEPVDLNELLEEVLEDLEPR 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 743 IAAGGVEIR-TDLATVWvqADASGLSIVMRNLLENAFKFSARAMPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFE 821
Cdd:COG4251 373 IEERGAEIEvGPLPTVR--GDPTLLRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFE 450
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1055322745 822 IFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAKG 874
Cdd:COG4251 451 IFQRLHSRDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
637-873 |
3.95e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 190.50 E-value: 3.95e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 637 RVVERTAELDILNKSLESFVYSVSHDLKAPLRGIEGYSQLLqEDYATALDDDGRLFIANIRNGVMCMGELIDDLLAYSRM 716
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELL-LDEEDLSPEERRELLEIIRESAERLLRLIEDLLDLSRL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 717 ERRKLDSNK--LDLALMINQLLAEKADDIAAGGVEIRTDLA--TVWVQADASGLSIVMRNLLENAFKFSARAmpPRIEIS 792
Cdd:COG2205 80 ESGKLSLELepVDLAELLEEAVEELRPLAEEKGIRLELDLPpeLPLVYADPELLEQVLANLLDNAIKYSPPG--GTITIS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 793 LREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:COG2205 158 ARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLA 237
|
.
gi 1055322745 873 K 873
Cdd:COG2205 238 E 238
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
551-872 |
9.91e-53 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 187.04 E-value: 9.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 551 YDFVNADLADFFHTNDRRALETNVTIINEEWLTFAETGYRGLFQTVKVPVFNVDGDVVGVLGIARDITALRQAEEDLRAI 630
Cdd:COG0642 9 VLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 631 NTGLEARVVERTAELDILNKSLESFVYSVSHDLKAPLRGIEGYSQLLQEDyataLDDDGRLFIANIRNGVMCMGELIDDL 710
Cdd:COG0642 89 LLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEE----LDEEQREYLETILRSADRLLRLINDL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 711 LAYSRMERRKLDSNK--LDLALMINQLLAEKADDIAAGGVEIRTDLA--TVWVQADASGLSIVMRNLLENAFKFSARAmp 786
Cdd:COG0642 165 LDLSRLEAGKLELEPepVDLAELLEEVVELFRPLAEEKGIELELDLPddLPTVRGDPDRLRQVLLNLLSNAIKYTPEG-- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 787 PRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFY 866
Cdd:COG0642 243 GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFT 322
|
....*.
gi 1055322745 867 LQLPLA 872
Cdd:COG0642 323 VTLPLA 328
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
554-873 |
7.22e-49 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 178.21 E-value: 7.22e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 554 VNADLADFFHTNDRRALETNVTIINEEWLTFAETGYRGLFQTVKVPVFNVDGDVVGVLGIARDITALRQAEEDLRAINTG 633
Cdd:COG5002 62 LLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSAL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 634 LEARVVERTAELDI-----LNKSLESFVYSVSHDLKAPLRGIEGYSQLLQEDyATALDDDGRLFIANIRNGVMCMGELID 708
Cdd:COG5002 142 LLGLLLLAAVERDItelerLEQMRREFVANVSHELRTPLTSIRGYLELLLDG-AADDPEERREYLEIILEEAERLSRLVN 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 709 DLLAYSRMERRKLDSNK--LDLALMINQLLAEKADDIAAGGVEIRTDLAT--VWVQADASGLSIVMRNLLENAFKFSara 784
Cdd:COG5002 221 DLLDLSRLESGELKLEKepVDLAELLEEVVEELRPLAEEKGIELELDLPEdpLLVLGDPDRLEQVLTNLLDNAIKYT--- 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 785 mPP--RIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRL--QRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPG 860
Cdd:COG5002 298 -PEggTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVdkSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPG 376
|
330
....*....|...
gi 1055322745 861 QGASFYLQLPLAK 873
Cdd:COG5002 377 KGTTFTITLPLAR 389
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
333-873 |
1.26e-43 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 165.53 E-value: 1.26e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 333 RRSEDELRLWtksFEQTQVGLVITDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDcKTDVQQMLADLaVKSHGI 412
Cdd:COG5809 11 RKSEQRFRSL---FENAPDAILILDLEGK-ILKVNPAAERIFGYTEDELLGTNILDFLHPD-DEKELREILKL-LKEGES 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 413 F---ETEHLCKDGRRLPVLLDITVIPDAEGRPLHRLTIVLNISERKRIQrdlesaqiqalqqqkearlailnqmqdanaa 489
Cdd:COG5809 85 RdelEFELRHKNGKRLEFSSKLSPIFDQNGDIEGMLAISRDITERKRME------------------------------- 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 490 rikaetalAALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRA 569
Cdd:COG5809 134 --------EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQL 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 570 LETNVTIINEEWLTFAEtGYRGLFQTVKVPVfNVDGDVVGVLGIARDITALRQAEEDLRAintglearvvertaeLDILN 649
Cdd:COG5809 206 LKDGGIAQGEVRFWTKD-GRWRLLEASGAPI-KKNGEVDGIVIIFRDITERKKLEELLRK---------------SEKLS 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 650 KSLEsFVYSVSHDLKAPLRGIEGYSQLLQEDyataLDDDGRLFIANIRNGVMCMGELIDDLLAYSRmeRRKLDSNKLDLA 729
Cdd:COG5809 269 VVGE-LAAGIAHEIRNPLTSLKGFIQLLKDT----IDEEQKTYLDIMLSELDRIESIISEFLVLAK--PQAIKYEPKDLN 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 730 LMINQ---LLAEKADdiaAGGVEIRTDLA--TVWVQADASGLSIVMRNLLENAFKfsarAMPPRIEISLR---EENHFAI 801
Cdd:COG5809 342 TLIEEvipLLQPQAL---LKNVQIELELEddIPDILGDENQLKQVFINLLKNAIE----AMPEGGNITIEtkaEDDDKVV 414
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1055322745 802 VKITDNGIGFDMIYHDRIFEIFqrlqrvedYP----GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:COG5809 415 ISVTDEGCGIPEERLKKLGEPF--------YTtkekGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLPIKL 482
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
458-871 |
2.19e-43 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 169.35 E-value: 2.19e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 458 QRDLESAQ-----IQALQQQ-------KEARLAILNQMQDANAARIKAETALAALSdseARMRVLINTIPDLIWLKNVDG 525
Cdd:PRK11091 99 ERDLELNVqlkdnIAQLNQEiaerekaEEARQEAFEQLKNEIKEREETQIELEQQS---SLLRSFLDASPDLVYYRNEDG 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 526 IYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEEWLTFAEtGYRGLFQTVKVPVFNVDG 605
Cdd:PRK11091 176 EFSGCNRAMELLTGKSEKQLIGLTPKDVYSPEAAEKVIETDEKVFRHNVSLTYEQWLDYPD-GRKACFELRKVPFYDRVG 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 606 DVVGVLGIARDITALRQAEEdlraintGLEARVVERTaeldilnksleSFVYSVSHDLKAPLRGIEGYSQLLQEdyaTAL 685
Cdd:PRK11091 255 KRHGLMGFGRDITERKRYQD-------ALEKASRDKT-----------TFISTISHELRTPLNGIVGLSRILLD---TEL 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 686 DDDGRLFIANIRNGVMCMGELIDDLLAYSRMERRK--LDSNKLDLALMINQ------LLAEKAD---DIaaggvEIRTDL 754
Cdd:PRK11091 314 TAEQRKYLKTIHVSAITLGNIFNDIIDMDKMERRKlqLDNQPIDFTDFLADlenlsgLQAEQKGlrfDL-----EPLLPL 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 755 ATvWVQADASGLSIVMRNLLENAFKFSARAmppriEISLR---EENHFAIVKITDNGIGfdmIYHDRIFEIFQRLQRVED 831
Cdd:PRK11091 389 PH-KVITDGTRLRQILWNLISNAVKFTQQG-----GVTVRvryEEGDMLTFEVEDSGIG---IPEDELDKIFAMYYQVKD 459
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1055322745 832 YP------GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK11091 460 SHggkpatGTGIGLAVSKRLAQAMGGDITVTSEEGKGSCFTLTIHA 505
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
480-873 |
1.34e-41 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 157.82 E-value: 1.34e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 480 LNQMqdanAARIKAETAlaALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNA-DL 558
Cdd:COG5000 71 FNRM----TDQLKEQRE--ELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLGIPLEELIGKPLEELLPElDL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 559 ADFFHTNDRRALETNVTIINEEWLTFAetgyrglfqtVKVPVFNVDGDVVgvlgIARDITALRQAEEdLRAIntgleARV 638
Cdd:COG5000 145 AELLREALERGWQEEIELTRDGRRTLL----------VRASPLRDDGYVI----VFDDITELLRAER-LAAW-----GEL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 639 VERtaeldilnkslesfvysVSHDLKAPLRGIEGYSQLLQEDYATALDDDGRLF---IANIRNGVMCMGELIDDLLAYSR 715
Cdd:COG5000 205 ARR-----------------IAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLeraLDTIIRQVDRLKRIVDEFLDFAR 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 716 MERRKLDsnKLDLALMINQLLAEKADDIAAGGVEIRTDLA--TVWVQADASGLSIVMRNLLENAfkfsARAMP--PRIEI 791
Cdd:COG5000 268 LPEPQLE--PVDLNELLREVLALYEPALKEKDIRLELDLDpdLPEVLADRDQLEQVLINLLKNA----IEAIEegGEIEV 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 792 SLREENHFAIVKITDNGIGF--DMIyhDRIFEifqrlqrvedyP-------GTGVGLALVKKAIQRMGGKVWAESEPGQG 862
Cdd:COG5000 342 STRREDGRVRIEVSDNGPGIpeEVL--ERIFE-----------PffttkpkGTGLGLAIVKKIVEEHGGTIELESRPGGG 408
|
410
....*....|.
gi 1055322745 863 ASFYLQLPLAK 873
Cdd:COG5000 409 TTFTIRLPLAE 419
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
499-874 |
2.48e-40 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 152.69 E-value: 2.48e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 499 ALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFV--NADLADFFHtndrRALETNVTI 576
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFpeDSPLRELLE----RALAEGQPV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 577 INEEWLTFAETGYRGLFQTVKVPVFNVDGDVvGVLGIARDITALRQAEEDLRAIntglearvvERTAeldilnkSLESFV 656
Cdd:COG3852 77 TEREVTLRRKDGEERPVDVSVSPLRDAEGEG-GVLLVLRDITERKRLERELRRA---------EKLA-------AVGELA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 657 YSVSHDLKAPLRGIEGYSQLLQEDYAtalDDDGRLFIANIRNGVMCMGELIDDLLAYSRMERRKLDsnkldlALMINQLL 736
Cdd:COG3852 140 AGLAHEIRNPLTGIRGAAQLLERELP---DDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPERE------PVNLHEVL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 737 AE-----KADdiAAGGVEIRTDLAT--VWVQADASGLSIVMRNLLENAfkfsARAMP--PRIEISLREENHFAI------ 801
Cdd:COG3852 211 ERvlellRAE--APKNIRIVRDYDPslPEVLGDPDQLIQVLLNLVRNA----AEAMPegGTITIRTRVERQVTLgglrpr 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 802 ----VKITDNGIGFDMIYHDRIFEifqrlqrvedyP-------GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:COG3852 285 lyvrIEVIDNGPGIPEEILDRIFE-----------PffttkekGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
|
....
gi 1055322745 871 LAKG 874
Cdd:COG3852 354 LEQA 357
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
363-871 |
1.52e-37 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 147.57 E-value: 1.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 363 IVSVNSAFALERGYTCEAMRQMPLAQLFPPD----CKTDVQQMLADLAVkshGIFETeHLCKDGRRLPVLLDITVIPDAE 438
Cdd:COG5805 56 VIYINPAMEKLLGYTSEEIIGKTIFDFLEKEyhyrVKTRIERLQKGYDV---VMIEQ-IYCKDGELIYVEVKLFPIYNQN 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 439 GrpLHRLTIVLNISERKRIQrdlesaqiqalqqqkearlailnqmqdanaarikaetalAALSDSEARMRVLINTIPDLI 518
Cdd:COG5805 132 G--QAAILALRDITKKKKIE---------------------------------------EILQEQEERLQTLIENSPDLI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 519 WLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVN-ADLADFFHTNDRRALETNVTIINEEWLTFaeTGYRGLFQTVK 597
Cdd:COG5805 171 CVIDTDGRILFINESIERLFGAPREELIGKNLLELLHpCDKEEFKERIESITEVWQEFIIEREIITK--DGRIRYFEAVI 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 598 VPVFNVDGDVVGVLGIARDITALRQAEEDLRaintglearvveRTAELDILNKslesFVYSVSHDLKAPLRGIEGYSQLL 677
Cdd:COG5805 249 VPLIDTDGSVKGILVILRDITEKKEAEELMA------------RSEKLSIAGQ----LAAGIAHEIRNPLTSIKGFLQLL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 678 Q---EDYATALDddgrlfianirngVMC-----MGELIDDLLAYSrmerrKLDSNKLDLALmINQLLAE-----KADDIA 744
Cdd:COG5805 313 QpgiEDKEEYFD-------------IMLseldrIESIISEFLALA-----KPQAVNKEKEN-INELIQDvvtllETEAIL 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 745 AgGVEIRTDL--ATVWVQADASGLSIVMRNLLENAFKfsarAMPP--RIEISLREENHFAIVKITDNGIGFDMIYHDRIF 820
Cdd:COG5805 374 H-NIQIRLELldEDPFIYCDENQIKQVFINLIKNAIE----AMPNggTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLG 448
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 821 EIFQRLQRvedyPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:COG5805 449 EPFFTTKE----KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-870 |
8.47e-37 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 133.61 E-value: 8.47e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSARAMPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKA 845
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHSREEYEGTGVGLAIVRKI 80
|
90 100
....*....|....*....|....*
gi 1055322745 846 IQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16921 81 IERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
330-627 |
1.07e-36 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 139.00 E-value: 1.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 330 TERRRSEDELRLWTKSFEQTQVGLVITDaRSNCIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLAVK- 408
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITD-LDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGg 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 409 SHGIFETEHLCKDGRRLPVLLDITVIPDAEGRPLHRLTIVLNISERKRIQRdlesaqiqalqqqkearlailnqmqdana 488
Cdd:COG2202 80 GVWRGELRNRRKDGSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEE----------------------------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 489 arikaetalaALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRR 568
Cdd:COG2202 131 ----------ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRR 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1055322745 569 ALETNVTIINEEWLTFAETGYRGLFQTVKVPVFNvDGDVVGVLGIARDITALRQAEEDL 627
Cdd:COG2202 201 LLEGGRESYELELRLKDGDGRWVWVEASAVPLRD-GGEVIGVLGIVRDITERKRAEEAL 258
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
613-872 |
1.14e-35 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 139.16 E-value: 1.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 613 IARDITALRQAEEDLRAintgLEARVV--ERTAeldilnkSLESFVYSVSHDLKAPLRGIEGYSQLLQEDYATALDDDG- 689
Cdd:COG4191 112 LERDITELERAEEELRE----LQEQLVqsEKLA-------ALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPDPEEl 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 690 RLFIANIRNGVMCMGELIDDLLAYSRmeRRKLDSNKLDLALMINQLLAEKADDIAAGGVEIRTDLAT--VWVQADASGLS 767
Cdd:COG4191 181 REALERILEGAERAAEIVRSLRAFSR--RDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPdlPPVLGDPGQLE 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 768 IVMRNLLENAfkfsARAMP----PRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDypGTGVGLALVK 843
Cdd:COG4191 259 QVLLNLLINA----IDAMEegegGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGK--GTGLGLSISY 332
|
250 260
....*....|....*....|....*....
gi 1055322745 844 KAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:COG4191 333 GIVEKHGGRIEVESEPGGGTTFTITLPLA 361
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
206-461 |
8.89e-31 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 122.06 E-value: 8.89e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 206 ETSQALAASLTRFRNLFQKAPLAMGLVDKQGIIQDQNVRFEQLFGYSAADMptLAEWCRRAYPDPVYRAEVEAIWNTAVA 285
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEEL--LGKTLRDLLPPEDDDEFLELLRAALAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 286 GSVEStdsidaGEFRISCKDGQQRIMHIHSIALK------EGLLTTFMDVTERRRSEDELR----LWTKSFEQTQVGLVI 355
Cdd:COG2202 79 GGVWR------GELRNRRKDGSLFWVELSISPVRdedgeiTGFVGIARDITERKRAEEALReseeRLRLLVENAPDGIFV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 356 TDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLAVKSHGIFETEHLCKDGRRLPVLLDITVIP 435
Cdd:COG2202 153 LDLDGR-ILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYELELRLKDGDGRWVWVEASAVP 231
|
250 260
....*....|....*....|....*..
gi 1055322745 436 DA-EGRPLHRLTIVLNISERKRIQRDL 461
Cdd:COG2202 232 LRdGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
761-872 |
4.31e-30 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 114.67 E-value: 4.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 761 ADASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRL-QRVEDYPGTGVGL 839
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEG--GRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTdKRSRKIGGTGLGL 78
|
90 100 110
....*....|....*....|....*....|...
gi 1055322745 840 ALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:smart00387 79 SIVKKLVELHGGEISVESEPGGGTTFTITLPLE 111
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
496-874 |
7.51e-29 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 122.77 E-value: 7.51e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 496 ALA-ALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDF--VNADLADFFHtndrRALET 572
Cdd:PRK11360 252 NLAqALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELfpPNTPFASPLL----DTLEH 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 573 NVTIINEEWLTFAETGYRGLFQTVKvPVFNVDGDVVGVLGIARDITALRQAEEDLRAintglearvVERTAeldilnkSL 652
Cdd:PRK11360 328 GTEHVDLEISFPGRDRTIELSVSTS-LLHNTHGEMIGALVIFSDLTERKRLQRRVAR---------QERLA-------AL 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 653 ESFVYSVSHDLKAPLRGIEGYSQLLQEDyatALDDDGRLFIANIRNGVMCMGELIDDLLAYSRMERRKLDsnKLDLALMI 732
Cdd:PRK11360 391 GELVAGVAHEIRNPLTAIRGYVQIWRQQ---TSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQ--PVSLNALV 465
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 733 NQLLAEKADDIAAGGVEIRTDLA----TVWvqADASGLSIVMRNLLENAFKfsarAMPPRIEISLR---EENHFAIVKIT 805
Cdd:PRK11360 466 EEVLQLFQTAGVQARVDFETELDnelpPIW--ADPELLKQVLLNILINAVQ----AISARGKIRIRtwqYSDGQVAVSIE 539
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 806 DNGIGFDMIYHDRIFEIF--QRLQrvedypGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAKG 874
Cdd:PRK11360 540 DNGCGIDPELLKKIFDPFftTKAK------GTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQ 604
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
653-872 |
1.21e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 120.72 E-value: 1.21e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 653 ESFVYSVSHDLKAPLRGIEGYSQLLQEDYAtalDDDGRLFIANIRNGVMCMGELIDDLLAYSRMERRK--LDSNKLDLAL 730
Cdd:PRK11100 257 EQYVQTLTHELKSPLAAIRGAAELLQEDPP---PEDRARFTGNILTQSARLQQLIDRLLELARLEQRQelEVLEPVALAA 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 731 MINQLLAEKADDIAAGGVEIRTDLATVWVQADASGLSIVMRNLLENAFKFSaramPP--RIEISLREENHFAIVKITDNG 808
Cdd:PRK11100 334 LLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFS----PEggTITLSAEVDGEQVALSVEDQG 409
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1055322745 809 IGFDMIYHDRIFEIFQRLQRVEDYP-GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:PRK11100 410 PGIPDYALPRIFERFYSLPRPANGRkSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRH 474
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
761-873 |
2.23e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 109.77 E-value: 2.23e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 761 ADASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHFAIVkITDNGIGFDMIYHDRIFEIFQRLQRVeDYPGTGVGLA 840
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKA--GEITVTLSEGGELTLT-VEDNGIGIPPEDLPRIFEPFSTADKR-GGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|...
gi 1055322745 841 LVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
766-869 |
4.12e-28 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 108.84 E-value: 4.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSARamPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKA 845
Cdd:cd00075 1 LEQVLSNLLDNALKYSPP--GGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 1055322745 846 IQRMGGKVWAESEPGQGASFYLQL 869
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
659-870 |
1.89e-22 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 100.41 E-value: 1.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 659 VSHDLKAPLRG----IEGYsQLLQEDYATALDDDGRL-FIANIRNGVMCMGELIDDLLAYSRMERRKLDSN--KLDLALM 731
Cdd:PRK09303 158 LAHDLRTPLTAaslaLETL-ELGQIDEDTELKPALIEqLQDQARRQLEEIERLITDLLEVGRTRWEALRFNpqKLDLGSL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 732 INQLLAEKADDIAAGGVEIRTD----LATVWvqADASGLSIVMRNLLENAFKFSaramPPRIEIS---LREENHFAIVKI 804
Cdd:PRK09303 237 CQEVILELEKRWLAKSLEIQTDipsdLPSVY--ADQERIRQVLLNLLDNAIKYT----PEGGTITlsmLHRTTQKVQVSI 310
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1055322745 805 TDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:PRK09303 311 CDTGPGIPEEEQERIFEDRVRLPRDEGTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLP 376
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
495-629 |
2.95e-21 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 94.32 E-value: 2.95e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 495 TALAALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNV 574
Cdd:COG2202 1 TAEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGG 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1055322745 575 TIINEEWLTFAEtGYRGLFQTVKVPVFNVDGDVVGVLGIARDITALRQAEEDLRA 629
Cdd:COG2202 81 VWRGELRNRRKD-GSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRE 134
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
769-871 |
5.34e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 88.70 E-value: 5.34e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAmppriEISLR-----EENHFAIVKIT--DNGIGFDMIYHDRIFEIFQR----LQRveDYPGTGV 837
Cdd:cd16922 4 ILLNLLGNAIKFTEEG-----EVTLRvsleeEEEDGVQLRFSveDTGIGIPEEQQARLFEPFSQadssTTR--KYGGTGL 76
|
90 100 110
....*....|....*....|....*....|....
gi 1055322745 838 GLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:cd16922 77 GLAISKKLVELMGGDISVESEPGQGSTFTFTLPL 110
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
490-873 |
1.86e-20 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 94.53 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 490 RIKAETALAALSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGkpevdilghtdYDFVNADLADFFHTNDRRA 569
Cdd:COG3290 69 AALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLG-----------LDAIGRPIDEVLAEVLETG 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 570 LETNVTIINEEWLTFAEtgyrglfqtvkVPVFnVDGDVVGVLGIARDITALRQAEEDLRAINTglearvvertaeldiLN 649
Cdd:COG3290 138 ERDEEILLNGRVLVVNR-----------VPIR-DDGRVVGAVATFRDRTELERLEEELEGVKE---------------LA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 650 KSLESFvysvSHDLKAPLRGIEGYSQLlqEDYATALDddgrlFIANIRNGvmcMGELIDDLLAYSRMErrkldsnkldla 729
Cdd:COG3290 191 EALRAQ----RHDFRNHLHTISGLLQL--GEYDEALE-----YIDEISEE---LQELIDSLLSRIGNP------------ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 730 lMINQLLAEKADDIAAGGVEIRTDLATVWVQA--DASGLSIVMRNLLENAFK--FSARAMPPRIEISLREENHFAIVKIT 805
Cdd:COG3290 245 -VLAALLLGKAARARERGIDLTIDIDSDLPDLplSDTDLVTILGNLLDNAIEavEKLPEEERRVELSIRDDGDELVIEVE 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1055322745 806 DNGIGFDMIYHDRIFEifqrlqrvEDYP-----GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:COG3290 324 DSGPGIPEELLEKIFE--------RGFStklgeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEG 388
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
613-871 |
6.08e-19 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 92.28 E-value: 6.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 613 IARDITALRQAEEDLRAINTGLEARVVERTAELDIL--------------NKSLESFVYSVSHDLKAPLRGIEGYSQLL- 677
Cdd:PRK11466 391 IGRLMDAFRSNVHALNRHREQLAAQVKARTAELQELviehrqaraeaekaSQAKSAFLAAMSHEIRTPLYGILGTAQLLa 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 678 -------QEDYATALDDDGRLFIAnirngvmcmgeLIDDLLAYSRMERRKLDSNKLDLALMINQLLaEKADDIAAGGVEI 750
Cdd:PRK11466 471 dnpalnaQRDDLRAITDSGESLLT-----------ILNDILDYSAIEAGGKNVSVSDEPFEPRPLL-ESTLQLMSGRVKG 538
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 751 R-----TDLATV---WVQADASGLSIVMRNLLENAFKFSARAMpprIEISLREENHFAIVKITDNGIGFDMIYHDRIFEI 822
Cdd:PRK11466 539 RpirlaTDIADDlptALMGDPRRIRQVITNLLSNALRFTDEGS---IVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQP 615
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1055322745 823 FqrLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK11466 616 F--VQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
512-622 |
7.89e-19 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 82.46 E-value: 7.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 512 NTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEEWLTFAetGYRG 591
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLN--GEER 79
|
90 100 110
....*....|....*....|....*....|.
gi 1055322745 592 LFQTVKVPVFNVDGDVVGVLGIARDITALRQ 622
Cdd:pfam08448 80 HYELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
634-871 |
1.48e-18 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 91.24 E-value: 1.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 634 LEARVVERTAELDILNKSLE-------SFVYSVSHDLKAPLRGIEGYSQLLQEdyaTALDDDGRLFIANIRNGVMCMGEL 706
Cdd:PRK15347 373 LENKVAERTQALAEAKQRAEqankrksEHLTTISHEIRTPLNGVLGALELLQN---TPLTAEQMDLADTARQCTLSLLAI 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 707 IDDLLAYSRMERRKLDSN--KLDLALMINQLLAEkaddIAAGGVEIRTDLATVwVQA--------DASGLSIVMRNLLEN 776
Cdd:PRK15347 450 INNLLDFSRIESGQMTLSleETALLPLLDQAMLT----IQGPAQSKSLTLRTF-VGAhvplylhlDSLRLRQILVNLLGN 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 777 AFKFSARAmppRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFqrLQRVEDYPGTGVGLALVKKAIQRMGGKVWAE 856
Cdd:PRK15347 525 AVKFTETG---GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPF--YQADTHSQGTGLGLTIASSLAKMMGGELTLF 599
|
250
....*....|....*
gi 1055322745 857 SEPGQGASFYLQLPL 871
Cdd:PRK15347 600 STPGVGSCFSLVLPL 614
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
632-873 |
6.75e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.94 E-value: 6.75e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 632 TGLEARVVER--------TAELDILNKSLE-SFVYSVSHDLKAPLRGIEGYSQLLQEDYATalddDGRLFI--AN-IRNG 699
Cdd:PRK10490 635 TLLIANALERltltaseeQARLASEREQLRnALLAALSHDLRTPLTVLFGQAEILTLDLAS----EGSPHArqASeIRQQ 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 700 VMCMGELIDDLLAYSRMERRKLDSNKLDLAL--MINQLLaeKADDIAAGGVEIRTDLAT--VWVQADASGLSIVMRNLLE 775
Cdd:PRK10490 711 VLNTTRLVNNLLDMARIQSGGFNLRKEWLTLeeVVGSAL--QMLEPGLSGHPINLSLPEplTLIHVDGPLFERVLINLLE 788
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 776 NAFKFSARAMPprIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWA 855
Cdd:PRK10490 789 NAVKYAGAQAE--IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKFARGNKESAIPGVGLGLAICRAIVEVHGGTIWA 866
|
250
....*....|....*...
gi 1055322745 856 ESEPGQGASFYLQLPLAK 873
Cdd:PRK10490 867 ENRPEGGACFRVTLPLET 884
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-870 |
8.60e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 76.56 E-value: 8.60e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 772 NLLENAFKFSARAMPP--RIEISLREENHFAIVKITDNGIGfdmIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRM 849
Cdd:cd16915 7 NLIDNALDALAATGAPnkQVEVFLRDEGDDLVIEVRDTGPG---IAPELRDKVFERGVSTKGQGERGIGLALVRQSVERL 83
|
90 100
....*....|....*....|.
gi 1055322745 850 GGKVWAESEPGQGASFYLQLP 870
Cdd:cd16915 84 GGSITVESEPGGGTTFSIRIP 104
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
530-870 |
1.23e-16 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 83.95 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 530 CNAAFERYYGKPEVDILGH---------TDYDFVnADLadffhtndRRALETNVTIiNEEWLTFAETG---YRGLFQTvk 597
Cdd:PRK13557 58 ANRAFLEMTGYAAEEIIGNncrflqgpeTDRATV-AEV--------RDAIAERREI-ATEILNYRKDGssfWNALFVS-- 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 598 vPVFNVDGDVVGVLGIARDITALRQAEEDLRaintglEARVVErtaeldilnkSLESFVYSVSHDLKAPLRGIEGYSQLL 677
Cdd:PRK13557 126 -PVYNDAGDLVYFFGSQLDVSRRRDAEDALR------QAQKME----------ALGQLTGGIAHDFNNLLQVMSGYLDVI 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 678 QEDYATALDDDGRLFIA--NIRNGVMCMGELIDDLLAYSRmeRRKLDSNKLDLALMINQL--LAEKAddiAAGGVEIRTD 753
Cdd:PRK13557 189 QAALSHPDADRGRMARSveNIRAAAERAATLTQQLLAFAR--KQRLEGRVLNLNGLVSGMgeLAERT---LGDAVTIETD 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 754 LAT-VW-VQADASGLSIVMRNLLENAfkfsaR-AMPPRIEISLREEN-----------------HFAIVKITDNGIGFDM 813
Cdd:PRK13557 264 LAPdLWnCRIDPTQAEVALLNVLINA-----RdAMPEGGRVTIRTRNveiededlamyhglppgRYVSIAVTDTGSGMPP 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1055322745 814 IYHDRIFEIFqrLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:PRK13557 339 EILARVMDPF--FTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRLYFP 393
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-871 |
3.47e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 71.97 E-value: 3.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSaramPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRL--QRVEDYPGTGVGLALVK 843
Cdd:cd16949 1 LARALENVLRNALRYS----PSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVdsARDRESGGTGLGLAIAE 76
|
90 100
....*....|....*....|....*...
gi 1055322745 844 KAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:cd16949 77 RAIEQHGGKIKASNRKPGGLRVRIWLPA 104
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
611-870 |
7.11e-15 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 77.74 E-value: 7.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 611 LGIARDITALRQAEEDLRaintglearvvertaeldilnksleSFVYSVSHDLKAPLRGIEGYSQLLQEDyatalDDDGR 690
Cdd:PRK11006 188 LMVARDVTQMHQLEGARR-------------------------NFFANVSHELRTPLTVLQGYLEMMQDQ-----PLEGA 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 691 LfianiRN---GVMC-----MGELIDDLLAYSRMERR-KLDSN-KLDLALMInQLLAEKADDIAAGGVEIRTDLATVW-V 759
Cdd:PRK11006 238 L-----REkalHTMReqtqrMEGLVKQLLTLSKIEAApTIDLNeKVDVPMML-RVLEREAQTLSQGKHTITFEVDNSLkV 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 760 QADASGLSIVMRNLLENAFKFSaramPP--RIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQ--RVEDYPGT 835
Cdd:PRK11006 312 FGNEDQLRSAISNLVYNAVNHT----PEgtHITVRWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRVDkaRSRQTGGS 387
|
250 260 270
....*....|....*....|....*....|....*
gi 1055322745 836 GVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:PRK11006 388 GLGLAIVKHALSHHDSRLEIESEVGKGTRFSFVLP 422
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
754-862 |
7.75e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 71.28 E-value: 7.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 754 LATVWVQADASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHfAIVKITDNGIGFDMIYHDRIFEIFQRLQRvEDYP 833
Cdd:cd16940 2 AADIQVQGDALLLFLLLRNLVDNAVRYSPQG--SRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSDG-QNYG 77
|
90 100
....*....|....*....|....*....
gi 1055322745 834 GTGVGLALVKKAIQRMGGKVWAESEPGQG 862
Cdd:cd16940 78 GSGLGLSIVKRIVELHGGQIFLGNAQGGG 106
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
601-871 |
2.67e-14 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 77.03 E-value: 2.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 601 FNVDGDVVGVLGIARDITALRQAEEDLRAINTGLEA-----RVVERTAELDILNKSLE---------SFVYSVSHDLKAP 666
Cdd:PRK13837 385 FKSGDRIVALLGLGRQRYGLRPPAGELQLLELALDClahaiERRRLETERDALERRLEharrleavgTLASGIAHNFNNI 464
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 667 LRGIEGYSQLLQEdyatALDDDGRL--FIANIRNGVMCMGELIDDLLAYSRmeRRKLDSNKLDLalmiNQLLAEKADDIA 744
Cdd:PRK13837 465 LGAILGYAEMALN----KLARHSRAarYIDEIISAGARARLIIDQILAFGR--KGERNTKPFDL----SELVTEIAPLLR 534
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 745 A---GGVEI--RTDLATVWVQADASGLSIVMRNLLENAfkfsARAMPP--RIEISLR--------EENH-------FAIV 802
Cdd:PRK13837 535 VslpPGVELdfDQDQEPAVVEGNPAELQQVLMNLCSNA----AQAMDGagRVDISLSraklrapkVLSHgvlppgrYVLL 610
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 803 KITDNGIGFDMIYHDRIFEIF--QRLQrvedypGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK13837 611 RVSDTGAGIDEAVLPHIFEPFftTRAG------GTGLGLATVHGIVSAHAGYIDVQSTVGRGTRFDVYLPP 675
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-871 |
5.53e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 68.61 E-value: 5.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSARamppRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQ--RVEDYPGTGVGLALVK 843
Cdd:cd16939 1 MARALDNLLRNALRYAHR----TVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDpsRDRATGGFGLGLAIVH 76
|
90 100
....*....|....*....|....*...
gi 1055322745 844 KAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:cd16939 77 RVALWHGGHVECDDSELGGACFRLTWPR 104
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-871 |
6.00e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 68.60 E-value: 6.00e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAfkfsARAMPPRIEISLR---EENHFAIVkITDNGIGFDMIYHDRIFEIFQRLQRVEDypGTGVGLALVKKA 845
Cdd:cd16943 7 VLLNLLVNA----AQAMEGRGRITIRtwaHVDQVLIE-VEDTGSGIDPEILGRIFDPFFTTKPVGE--GTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*.
gi 1055322745 846 IQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:cd16943 80 IQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
659-871 |
9.04e-14 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 74.25 E-value: 9.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 659 VSHDLKAP---LRGIEGYSQLLQEDYATALDDD-GRLfianirngvmcmGELIDDLLAYSRMERRKLDSN--KLDLAlmi 732
Cdd:PRK10604 219 IAHELRTPlvrLRYRLEMSDNLSAAESQALNRDiGQL------------EALIEELLTYARLDRPQNELHlsEPDLP--- 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 733 nQLLAEKADDIAAGGVEIRTDLAT-----VWVqADASGLSIVMRNLLENAFKFSARamppRIEISLREENHFAIVKITDN 807
Cdd:PRK10604 284 -AWLSTHLADIQAVTPEKTVRLDTphqgdYGA-LDMRLMERVLDNLLNNALRYAHS----RVRVSLLLDGNQACLIVEDD 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1055322745 808 GIGFDMIYHDRIFEIFQRLQRVEDYP--GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK10604 358 GPGIPPEERERVFEPFVRLDPSRDRAtgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPV 423
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
762-870 |
3.80e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.54 E-value: 3.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 762 DASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIF-----QRLQRvedyPGTG 836
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQG--GKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGftgenGRNFQ----ESTG 75
|
90 100 110
....*....|....*....|....*....|....
gi 1055322745 837 VGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16948 76 MGLYLVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
762-870 |
4.23e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 66.36 E-value: 4.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 762 DASGLSIVMRNLLENAFKFSARAMPPRIEISLREENHFAIVkITDNGIGFDMIYHDRIFEIFQRL--QRVEDYPGTGVGL 839
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLT-VSDSGPGIPPNLREEIFERFRQGdgSSTRAHGGTGLGL 79
|
90 100 110
....*....|....*....|....*....|.
gi 1055322745 840 ALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16925 80 SIVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
659-872 |
4.99e-13 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 72.25 E-value: 4.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 659 VSHDLKAPLRGIEGYSQLLQEDyatalddDGRL---FIANIRNgvmcMGELIDDLLAYSR----MERRKLDsnkldlalm 731
Cdd:PRK09467 236 VSHDLRTPLTRIRLATEMMSEE-------DGYLaesINKDIEE----CNAIIEQFIDYLRtgqeMPMEMAD--------- 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 732 INQLLAEKADDIAAGGVEIRTDLATVWVQADASGLSI--VMRNLLENAFKFSARamppRIEISLREENHFAIVKITDNGI 809
Cdd:PRK09467 296 LNALLGEVIAAESGYEREIETALQPGPIEVPMNPIAIkrALANLVVNAARYGNG----WIKVSSGTEGKRAWFQVEDDGP 371
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1055322745 810 GFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:PRK09467 372 GIPPEQLKHLFQPFTRGDSARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWLPLT 434
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
658-872 |
5.14e-13 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 71.82 E-value: 5.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 658 SVSHDLKAPLRGIEGYSQLLQEDYATALDDDGRLFIAnirngvmcMGEL------IDDLLAYSRMERRKLDsnKLDLALM 731
Cdd:COG5806 207 SIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIA--------LEELdraeaiITDYLTFAKPQPEKLE--KIDVSEE 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 732 INQ---LLAEKAddiAAGGVEIRTDLA-TVWVQADASGLSIVMRNLLENAFKfsarAMPP--RIEISLREENHFAIVKIT 805
Cdd:COG5806 277 LEHvidVLSPYA---NMNNVEIQTELEpGLYIEGDRQKLQQCLINIIKNGIE----AMPNggTLTIDVSIDKNKVIISIK 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1055322745 806 DNGIGFDMiyhdrifeifQRLQRV-EDY-----PGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:COG5806 350 DTGVGMTK----------EQLERLgEPYfstkeKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTITLPLA 412
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
201-339 |
1.83e-12 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 68.51 E-value: 1.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 201 RLRLEEtsqALAASLTRFRNLFQKAPLAMGLVDKQGIIQDQNVRFEQLFGYSAADMPTLAEWcrrAYPDPVYRAEVEAIW 280
Cdd:COG2202 125 RKRAEE---ALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLL---DLLHPEDRERLLELL 198
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1055322745 281 NTAVAGSVESTDsidaGEFRISCKDGQQRIMHIHSIALKE-----GLLTTFMDVTERRRSEDEL 339
Cdd:COG2202 199 RRLLEGGRESYE----LELRLKDGDGRWVWVEASAVPLRDggeviGVLGIVRDITERKRAEEAL 258
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
622-871 |
3.54e-12 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 70.26 E-value: 3.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 622 QAEEDLRAINTGLEARVVErtaeLDILNK-SLES------FVYSVSHDLKAPLRGIEGYS-QLL-------QEDY----- 681
Cdd:PRK11107 260 QATSDLRETLEQMEIQNVE----LDLAKKrAQEAarikseFLANMSHELRTPLNGVIGFTrQTLktpltptQRDYlqtie 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 682 --ATALdddgrLFIanirngvmcmgelIDDLLAYSrmerrKLDSNKL-------DLALMINQ---LLAEKADDiaaGGVE 749
Cdd:PRK11107 336 rsANNL-----LAI-------------INDILDFS-----KLEAGKLvlenipfSLRETLDEvvtLLAHSAHE---KGLE 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 750 IrtdlaTVWVQA--------DASGLSIVMRNLLENAFKFSARAMPpRIEISLREENHFAI---VKITDNGIGFDMIYHDR 818
Cdd:PRK11107 390 L-----TLNIDPdvpdnvigDPLRLQQIITNLVGNAIKFTESGNI-DILVELRALSNTKVqleVQIRDTGIGISERQQSQ 463
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1055322745 819 IFEIFqrlqRVED------YPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK11107 464 LFQAF----RQADasisrrHGGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWFHLPL 518
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
762-870 |
5.63e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 62.94 E-value: 5.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 762 DASGLSIVMRNLLENAFKFSARAMPPRIEISLREENHFA---IVKITDNGIGFDMIYHDRIFEIFqrlqrVEDYP-GTGV 837
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRPSDVGEVRIRVEADQDgriVLIVCDNGKGFPREMRHRATEPY-----VTTRPkGTGL 75
|
90 100 110
....*....|....*....|....*....|...
gi 1055322745 838 GLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16944 76 GLAIVKKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-869 |
6.67e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 62.47 E-value: 6.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAMPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDypGTGVGLALVKKAIQR 848
Cdd:cd16976 4 VLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGK--GTGLGLSISYGIVEE 81
|
90 100
....*....|....*....|.
gi 1055322745 849 MGGKVWAESEPGQGASFYLQL 869
Cdd:cd16976 82 HGGRLSVANEEGAGARFTFDL 102
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
748-869 |
1.24e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 62.53 E-value: 1.24e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 748 VEIRTDLATVWVQADASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEifqRLQ 827
Cdd:cd16947 3 VEINIPDRPIYANANTEALQRILKNLISNAIKYGSDG--KFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFE---RLY 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1055322745 828 RVED-----YPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQL 869
Cdd:cd16947 78 TLEDsrnsaKQGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
727-865 |
1.46e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 62.65 E-value: 1.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 727 DLALMINQLLAEKaddiaagGVEIRTDL--ATVWVqADASGLSIVMRNLLENAFKFSARamppRIEISLREENHFAIVKI 804
Cdd:cd16954 5 SLCSALNKVYQRK-------GVSISLDIspELRFP-GERNDLMELLGNLLDNACKWCLE----FVEVTARQTDGGLHLIV 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1055322745 805 TDNGIGfdmIYHDRIFEIFQRLQRV-EDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASF 865
Cdd:cd16954 73 DDDGPG---VPESQRSKIFQRGQRLdEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARF 131
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
769-870 |
1.71e-11 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 67.63 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAMPPRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEifqrlqrvEDY----PGTGVGLALVKK 844
Cdd:PRK11086 437 ILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFD--------KGYstkgSNRGVGLYLVKQ 508
|
90 100
....*....|....*....|....*.
gi 1055322745 845 AIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:PRK11086 509 SVENLGGSIAVESEPGVGTQFFVQIP 534
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
210-344 |
2.18e-11 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 66.41 E-value: 2.18e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 210 ALAASLTRFRNLFQKAPLAMGLVDKQGIIQDQNVRFEQLFGYSAADMP--TLAEWCrraypdPVYRAEVEAIWNTAVAGS 287
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLgrPLAELF------PEDSPLRELLERALAEGQ 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1055322745 288 vestdSIDAGEFRISCKDGQQRIMHIHSIALKE-----GLLTTFMDVTERRRSEDELRLWTK 344
Cdd:COG3852 75 -----PVTEREVTLRRKDGEERPVDVSVSPLRDaegegGVLLVLRDITERKRLERELRRAEK 131
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
193-510 |
2.49e-11 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 67.39 E-value: 2.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 193 SRRQENQHRLRLEETsqalaasltRFRNLFQKAPLAMGLVDKQGIIQD-QNVRFEQLFGYSAADM---------PTLAE- 261
Cdd:PRK13560 318 SGRRAAERELLEKED---------MLRAIIEAAPIAAIGLDADGNICFvNNNAAERMLGWSAAEVmgkplpgmdPELNEe 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 262 -WC---RRAYPDpvyrAEVEAIWNTAVAGSVESTDSIDAGEFRISCKDGQQRIMHIHSIALKE------GLLTTFMDVTE 331
Cdd:PRK13560 389 fWCgdfQEWYPD----GRPMAFDACPMAKTIKGGKIFDGQEVLIEREDDGPADCSAYAEPLHDadgniiGAIALLVDITE 464
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 332 RRRSEDELRLWTKSFEQTQVGLVITDARSNCIVSVNSAFALERGYTCEAM--RQMPLAQLFPPDCKTDVQQMLADLAVKS 409
Cdd:PRK13560 465 RKQVEEQLLLANLIVENSPLVLFRWKAEEGWPVELVSKNITQFGYEPDEFisGKRMFAAIIHPADLEQVAAEVAEFAAQG 544
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 410 HGIFETEH--LCKDGRRLPVLLDITVIPDAEGRPLHRLTIVLNISERKRIQRDLESAQIQALQQQKEARLAILNQMQ--- 484
Cdd:PRK13560 545 VDRFEQEYriLGKGGAVCWIDDQSAAERDEEGQISHFEGIVIDISERKHAEEKIKAALTEKEVLLKEIHHRVKNNLQiis 624
|
330 340
....*....|....*....|....*....
gi 1055322745 485 ---DANAARIKAETALAALSDSEARMRVL 510
Cdd:PRK13560 625 sllDLQAEKLHDEEAKCAFAESQDRICAM 653
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
335-461 |
4.16e-11 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 61.15 E-value: 4.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 335 SEDELRLwtkSFEQTQVGLVITDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLAVKSHGIFE 414
Cdd:TIGR00229 1 SEERYRA---IFESSPDAIIVIDLEGN-ILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVS 76
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1055322745 415 TEH--LCKDGRRLPVLLDITVIPDAeGRPLHRLTIVLNISERKRIQRDL 461
Cdd:TIGR00229 77 EERrvRRKDGSEIWVEVSVSPIRTN-GGELGVVGIVRDITERKEAEEAL 124
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
421-873 |
5.04e-11 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 66.08 E-value: 5.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 421 DGRRLPVLLDITVIPDAEGRPLHRLTIVLNISERKRIQRDLESAQIQALQQQKEARLAILNQMQDANAARIKAETALAAL 500
Cdd:COG3920 82 LALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALL 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 501 SDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEE 580
Cdd:COG3920 162 LLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEEL 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 581 WLTFAETGYRGLFQTVKVPVFNVDGDVVGVLGIARDITALRQAEEDLRAINtglearvvertAELDILNKslEsfvysVS 660
Cdd:COG3920 242 ERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASL-----------EEKELLLR--E-----LH 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 661 HDLK-------APLRgiegysqlLQEDYATalDDDGRLFIANIRNGVMCMGeLIDDLLAysrmerRKLDSNKLDLALMIN 733
Cdd:COG3920 304 HRVKnnlqvvsSLLR--------LQARRAD--DPEAREALEESQNRIQALA-LVHELLY------QSEDWEGVDLRDYLR 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 734 QLLAEKADDIAAGGVEIRTDLATVWVQAD-ASGLSIVMRNLLENAFKFSARAMP-PRIEISLREENHFAIVKITDNGIGF 811
Cdd:COG3920 367 ELLEPLRDSYGGRGIRIELDGPDVELPADaAVPLGLILNELVTNALKHAFLSGEgGRIRVSWRREDGRLRLTVSDNGVGL 446
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1055322745 812 DmiyhdrifeifqrlQRVEDYPGTGVGLALVKKAIQRMGGKVwaESEPGQGASFYLQLPLAK 873
Cdd:COG3920 447 P--------------EDVDPPARKGLGLRLIRALVRQLGGTL--ELDRPEGTRVRITFPLAE 492
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-870 |
5.40e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 60.29 E-value: 5.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 772 NLLENAFKFSaramPPRIEISLR--EENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQ--RVEDYPGTGVGLALVKKAIQ 847
Cdd:cd16952 7 NLVSNAVKYT----PPSDTITVRwsQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDieRCRNTGGTGLGLAIVKHVMS 82
|
90 100
....*....|....*....|...
gi 1055322745 848 RMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16952 83 RHDARLLIASELGKGSRFTCLFP 105
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
214-339 |
7.74e-11 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 60.38 E-value: 7.74e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 214 SLTRFRNLFQKAPLAMGLVDKQGIIQDQNVRFEQLFGYSAADMPTLAEWCRRAYPDpvyRAEVEAIWNTAVAGSVEstds 293
Cdd:TIGR00229 1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEED---REEVRERIERRLEGEPE---- 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 294 IDAGEFRISCKDGQQRIMHIH-SIALKEGLLTTFM----DVTERRRSEDEL 339
Cdd:TIGR00229 74 PVSEERRVRRKDGSEIWVEVSvSPIRTNGGELGVVgivrDITERKEAEEAL 124
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
625-871 |
8.50e-11 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 65.91 E-value: 8.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 625 EDLRAINTGLEARVVERTAELD-ILNKSleSFVYSVSHDLKAPLRGIEGYSQLLQedyATALDDDGRLFIANIR--NGVM 701
Cdd:PRK09959 686 QDITETRDLIHALEVERNKAINaTVAKS--QFLATMSHEIRTPISSIMGFLELLS---GSGLSKEQRVEAISLAyaTGQS 760
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 702 CMGeLIDDLLAYSRME--RRKLDSNKLDLALMINQLLAEKADDIAAGGVEIR---TDLATVWVQADASGLSIVMRNLLEN 776
Cdd:PRK09959 761 LLG-LIGEILDVDKIEsgNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALScssTFPDHYLVKIDPQAFKQVLSNLLSN 839
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 777 AFKFSARAmPPRIEISLR--EENHfAIVKIT--DNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQRMGGK 852
Cdd:PRK09959 840 ALKFTTEG-AVKITTSLGhiDDNH-AVIKMTimDSGSGLSQEEQQQLFKRYSQTSAGRQQTGSGLGLMICKELIKNMQGD 917
|
250
....*....|....*....
gi 1055322745 853 VWAESEPGQGASFYLQLPL 871
Cdd:PRK09959 918 LSLESHPGIGTTFTITIPV 936
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
500-628 |
1.56e-10 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 64.41 E-value: 1.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 500 LSDSEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFvnadladFFHTNDRRALETNVTIINE 579
Cdd:COG3829 6 LKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTEL-------IPNSPLLEVLKTGKPVTGV 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1055322745 580 EWLTfaeTGYRGLFQTVKVPVFnVDGDVVGVLGIARDITALRQAEEDLR 628
Cdd:COG3829 79 IQKT---GGKGKTVIVTAIPIF-EDGEVIGAVETFRDITELKRLERKLR 123
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
659-872 |
8.69e-10 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 62.11 E-value: 8.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 659 VSHDLKAPLRGIEGYSQLLQEDYATALDDDGrlfIANIRNG-VMCMGELIDDLLAYSRMERRKLDSnkLDLALMINQLLA 737
Cdd:PRK10364 244 VAHEIRNPLSSIKGLAKYFAERAPAGGEAHQ---LAQVMAKeADRLNRVVSELLELVKPTHLALQA--VDLNDLINHSLQ 318
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 738 EKADDIAAGGVEIRTDLATVW--VQADASGLSIVMRNLLENAFKfsarAMPP--RIEISLREENHFAIVKITDNGIGFDM 813
Cdd:PRK10364 319 LVSQDANSREIQLRFTANDTLpeIQADPDRLTQVLLNLYLNAIQ----AIGQhgVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1055322745 814 IYHDRIFEIFQRLQRvedyPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLA 872
Cdd:PRK10364 395 DQLEAIFTPYFTTKA----EGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVN 449
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
503-627 |
1.56e-09 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 56.53 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 503 SEARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEEWL 582
Cdd:TIGR00229 1 SEERYRAIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEERR 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1055322745 583 TFAETGYRGLFQTVKVPVFNvDGDVVGVLGIARDITALRQAEEDL 627
Cdd:TIGR00229 81 VRRKDGSEIWVEVSVSPIRT-NGGELGVVGIVRDITERKEAEEAL 124
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
617-870 |
2.25e-09 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 61.24 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 617 ITALRQAEEDLRAINTGLEarvveRTAELDILNKSLESfvysVSHDLKAPLRGIEGYS-----QLLQEDYATALDddgrl 691
Cdd:COG4192 407 IEERKRIEKNLRQTQDELI-----QAAKMAVVGQTMTS----LAHELNQPLNAMSMYLfsakkALEQENYAQLPT----- 472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 692 FIANIRNGVMCMGELIDDLLAYSRMERRKLDSnkLDLALMINQ---LLAEKADDiAAGGVEIRTDLatvWVQADASGLSI 768
Cdd:COG4192 473 SLDKIEGLIERMDKIIKSLRQFSRKSDTPLQP--VDLRQVIEQaweLVESRAKP-QQITLHIPDDL---MVQGDQVLLEQ 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKfsARAMPPRIEISLREENHFAIVKITDNGIGFDMIyhDRIFEIFQRLQRVedypGTGVGLALVKKAIQR 848
Cdd:COG4192 547 VLVNLLVNALD--AVATQPQISVDLLSNAENLRVAISDNGNGWPLV--DKLFTPFTTTKEV----GLGLGLSICRSIMQQ 618
|
250 260
....*....|....*....|..
gi 1055322745 849 MGGKVWAESEPGQGASFYLQLP 870
Cdd:COG4192 619 FGGDLYLASTLERGAMVILEFN 640
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
649-715 |
3.79e-09 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 53.37 E-value: 3.79e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055322745 649 NKSLESFVYSVSHDLKAPLRGIEGYSQLLQEDyaTALDDDGRLFIANIRNGVMCMGELIDDLLAYSR 715
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLEEE--LLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-870 |
7.67e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 53.99 E-value: 7.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAmpprIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQR 848
Cdd:cd16950 4 VLSNLVDNALRYGGGW----VEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTGLGLAIVQRISDA 79
|
90 100
....*....|....*....|..
gi 1055322745 849 MGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16950 80 HGGSLTLANRAGGGLCARIELP 101
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
651-717 |
8.68e-09 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 52.60 E-value: 8.68e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055322745 651 SLESFVYSVSHDLKAPLRGIEGYSQLLQEdyaTALDDDGRLFIANIRNGVMCMGELIDDLLAYSRME 717
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLELLRD---EKLDEEQREYLETILRSAERLLRLINDLLDLSRIE 64
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
505-617 |
9.24e-09 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 53.96 E-value: 9.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 505 ARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALETNVTIINEEWLTF 584
Cdd:pfam00989 1 EDLRAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFEVSFR 80
|
90 100 110
....*....|....*....|....*....|...
gi 1055322745 585 AETGYRGLFQTVKVPVFNVDGDVVGVLGIARDI 617
Cdd:pfam00989 81 VPDGRPRHVEVRASPVRDAGGEILGFLGVLRDI 113
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
650-871 |
1.16e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 58.83 E-value: 1.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 650 KSLesFVYSVSHDLKAPLRGIEGYSQLLQedyATALDDDGRLFIANIRNGVMCMGELIDDLLAYSRMERR--KLDSNKLD 727
Cdd:PRK10841 447 KSM--FLATVSHELRTPLYGIIGNLDLLQ---TKELPKGVDRLVTAMNNSSSLLLKIISDILDFSKIESEqlKIEPREFS 521
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 728 LALMINQLLAEKADDIAAGGVE----IRTDLAtVWVQADASGLSIVMRNLLENAFKFSARAMpprIEISLREENHFAIVK 803
Cdd:PRK10841 522 PREVINHITANYLPLVVKKRLGlycfIEPDVP-VALNGDPMRLQQVISNLLSNAIKFTDTGC---IVLHVRVDGDYLSFR 597
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 804 ITDNGIGFDMIYHDRIFE-IFQRLQRVE-DYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK10841 598 VRDTGVGIPAKEVVRLFDpFFQVGTGVQrNFQGTGLGLAICEKLINMMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
651-717 |
1.17e-08 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 52.18 E-value: 1.17e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055322745 651 SLESFVYSVSHDLKAPLRGIEGYSQLLQEdyaTALDDDGRLFIANIRNGVMCMGELIDDLLAYSRME 717
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLD---TELSEEQREYLETILREAERLLRLINDLLDLSRIE 64
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
298-635 |
1.21e-08 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 58.92 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 298 EFRISCKDGQ--------QRimHIHSIALKEGLLttfMDVTERRRSE----DELRLWTKSFEQT--QVGLVITDARsncI 363
Cdd:PRK13560 155 EGHFRCGDGRfidcclrfER--HAHADDQVDGFA---EDITERKRAEeridEALHFLQQLLDNIadPAFWKDEDAK---V 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 364 VSVNSAFALERGYTCEAMRQMPLAQlFPPDCKTDVQQMLADLAVKSHG--IFETEHLCKDGRRLP--VLLDITVIPDAEG 439
Cdd:PRK13560 227 FGCNDAACLACGFRREEIIGMSIHD-FAPAQPADDYQEADAAKFDADGsqIIEAEFQNKDGRTRPvdVIFNHAEFDDKEN 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 440 RPLHRLTIVLNISERKRIQRDLEsaqiqalqqqkearlailnqmqdanaarikaetalaalsDSEARMRVLINTIPDLIW 519
Cdd:PRK13560 306 HCAGLVGAITDISGRRAAERELL---------------------------------------EKEDMLRAIIEAAPIAAI 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 520 LKNVDG-IYLQCNAAFERYYGKPEVDILGHTDYDfVNADLADFFHTNDRRALETNVTIINEEWLTFAETGYRG-LFQTVK 597
Cdd:PRK13560 347 GLDADGnICFVNNNAAERMLGWSAAEVMGKPLPG-MDPELNEEFWCGDFQEWYPDGRPMAFDACPMAKTIKGGkIFDGQE 425
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 1055322745 598 V-----------------PVFNVDGDVVGVLGIARDITALRQAEEDLRAINTGLE 635
Cdd:PRK13560 426 VliereddgpadcsayaePLHDADGNIIGAIALLVDITERKQVEEQLLLANLIVE 480
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
788-870 |
1.31e-08 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 55.28 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 788 RIEISLREENHFAIVKITDNGIGFDmiyHDRI--------------------FEIFQRL--------QRVEDYPGTGVGL 839
Cdd:cd16916 71 TITLRAEHQGNQVVIEVSDDGRGID---REKIrekaierglitadeaatlsdDEVLNLIfapgfstaEQVTDVSGRGVGM 147
|
90 100 110
....*....|....*....|....*....|.
gi 1055322745 840 ALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16916 148 DVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
773-874 |
1.59e-08 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 58.11 E-value: 1.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 773 LLENAFKFSARAMPP--RIEISLREENHFAIVKITDNGIGFDMiyhDRIFEIFQRLQRVEDypGTGVGLALVKKAIQRMG 850
Cdd:COG2972 344 LVENAIEHGIEPKEGggTIRISIRKEGDRLVITVEDNGVGMPE---EKLEKLLEELSSKGE--GRGIGLRNVRERLKLYY 418
|
90 100
....*....|....*....|....*..
gi 1055322745 851 GK---VWAESEPGQGASFYLQLPLAKG 874
Cdd:COG2972 419 GEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
346-456 |
2.60e-08 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 52.80 E-value: 2.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 346 FEQTQVGLVITDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLAVKSHGIFETEHLCKDGRRL 425
Cdd:pfam08448 1 LDSLPDALAVLDPDGR-VRYANAAAAELFGLPPEELLGKTLAELLPPEDAARLERALRRALEGEEPIDFLEELLLNGEER 79
|
90 100 110
....*....|....*....|....*....|.
gi 1055322745 426 PVLLDITVIPDAEGRPLHRLTIVLNISERKR 456
Cdd:pfam08448 80 HYELRLTPLRDPDGEVIGVLVISRDITERRR 110
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
766-870 |
5.23e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 51.80 E-value: 5.23e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSaramPP---RIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIF--QRLQRVEDYPGTGVGLA 840
Cdd:cd16953 1 LGQVLRNLIGNAISFS----PPdtgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFytERPANEAFGQHSGLGLS 76
|
90 100 110
....*....|....*....|....*....|....
gi 1055322745 841 LVKKAIQRMGGKVWAE--SEPGQ--GASFYLQLP 870
Cdd:cd16953 77 ISRQIIEAHGGISVAEnhNQPGQviGARFTVQLP 110
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
656-873 |
9.59e-08 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 55.32 E-value: 9.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 656 VYSVSHDLKAPL-RgiegysqlLQedYATAL----DDDGRLfIANIRNGVMCMGELIDDLLAYSRME-RRKLDSNKLDla 729
Cdd:PRK09470 247 LSDISHELRTPLtR--------LQ--LATALlrrrQGESKE-LERIETEAQRLDSMINDLLVLSRNQqKNHLERETFK-- 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 730 lmINQLLAEKADDiaAG--------GVEIRTDLATVWVQADASGLSIVMRNLLENAFKFSARamppRIEISLREENHFAI 801
Cdd:PRK09470 314 --ANSLWSEVLED--AKfeaeqmgkSLTVSAPPGPWPINGNPNALASALENIVRNALRYSHT----KIEVAFSVDKDGLT 385
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1055322745 802 VKITDNGIGFDMIYHDRIFEIFQRLQRVEDYP--GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:PRK09470 386 ITVDDDGPGVPEEEREQIFRPFYRVDEARDREsgGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYK 459
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-870 |
1.29e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 50.46 E-value: 1.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSaraMP-PRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDYPGTGVGLALVKKAIQ 847
Cdd:cd16923 4 VFSNLLSNAIKYS---PEnTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRNTEGAGLGLSIAKAIIE 80
|
90 100
....*....|....*....|...
gi 1055322745 848 RMGGKVWAESEpGQGASFYLQLP 870
Cdd:cd16923 81 LHGGSASAEYD-DNHDLFKVRLP 102
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
773-870 |
1.39e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 50.13 E-value: 1.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 773 LLENAFKFSARAMPP--RIEISLREENHFAIVKITDNGIGFDMIyhdrifeifqRLQRVEDYPGTGVGLALVKKAIQRMG 850
Cdd:cd16956 9 IVENAVKHGLSGLLDggRVEITARLDGQHLLLEVEDNGGGMDPD----------TLARILIRSSNGLGLNLVDKRLRQAF 78
|
90 100
....*....|....*....|...
gi 1055322745 851 GKVWA---ESEPGQGASFYLQLP 870
Cdd:cd16956 79 GNDYGldiECAPGEGTRITIRLP 101
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
655-844 |
1.64e-07 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 54.66 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 655 FVYSVSHDLKAPLRGIEgysqlLQEDYATALDDDGRL---FIANIRNGVMCMGELIDDLLAYSRmerrkLDS--NKLDLA 729
Cdd:PRK10337 240 FTSDAAHELRSPLAALK-----VQTEVAQLSDDDPQArkkALLQLHAGIDRATRLVDQLLTLSR-----LDSldNLQDVA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 730 -LMINQLLAEKADDI----AAGGVEIRTDLATVWV--QADASGLSIVMRNLLENAFKFSARAmpPRIEISLrEENHFaiv 802
Cdd:PRK10337 310 eIPLEDLLQSAVMDIyhtaQQAGIDVRLTLNAHPVirTGQPLLLSLLVRNLLDNAIRYSPQG--SVVDVTL-NARNF--- 383
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1055322745 803 KITDNGIGFDMIYHDRIFEIFQRLQRvEDYPGTGVGLALVKK 844
Cdd:PRK10337 384 TVRDNGPGVTPEALARIGERFYRPPG-QEATGSGLGLSIVRR 424
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
655-852 |
2.20e-07 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 53.82 E-value: 2.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 655 FVYSVSHDLKAPLRGIEGYSQLLQEDYATalddDGRLFIANIRNgvmcMGELIDDLLAYSRMERRKLDSNKLDLALM--- 731
Cdd:PRK10755 140 FTADVAHELRTPLAGIRLHLELLEKQHHI----DVAPLIARLDQ----MMHTVEQLLQLARAGQSFSSGHYQTVKLLedv 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 732 INQLLAEKADDIAAGGVEIR--TDLATVWVQADASGLSIVMRNLLENAFKFSaramPP--RIEISLREENHFAIVKITDN 807
Cdd:PRK10755 212 ILPSQDELSEMLEQRQQTLLlpESAADITVQGDATLLRLLLRNLVENAHRYS----PEgsTITIKLSQEDGGAVLAVEDE 287
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1055322745 808 GIGFDMIYHDRIFEIFQRL-QRvedYPGTGVGLALVKKAIQRMGGK 852
Cdd:PRK10755 288 GPGIDESKCGELSKAFVRMdSR---YGGIGLGLSIVSRITQLHHGQ 330
|
|
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
773-873 |
2.39e-07 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 53.72 E-value: 2.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 773 LLENAFK--FSARAMPPRIEISLREENHFAIVKITDNGIGFdmiyhdrifeifqrlQRVEDYPGTGVGLALVKKAIQRMG 850
Cdd:COG3275 261 LVENAIKhgISSKEGGGTISISIEVEGDRLVIEVENNGVGI---------------QPKKKKKGSGIGLKNVRERLELLY 325
|
90 100
....*....|....*....|....*.
gi 1055322745 851 GKVWA---ESEPGQGASFYLQLPLAK 873
Cdd:COG3275 326 GDKYSleiESTDGGGTKVTLKIPLKK 351
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
363-453 |
2.70e-07 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 49.38 E-value: 2.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 363 IVSVNSAFALERGYTCEAMRQMPLAQLFP-PDCKTDVQQMLADLavKSHGIFETEHLCKDGRRLPVLLDITVIPDAEGRP 441
Cdd:pfam13426 4 IIYVNDAALRLLGYTREELLGKSITDLFAePEDSERLREALREG--KAVREFEVVLYRKDGEPFPVLVSLAPIRDDGGEL 81
|
90
....*....|..
gi 1055322745 442 LHRLTIVLNISE 453
Cdd:pfam13426 82 VGIIAILRDITE 93
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
351-451 |
2.73e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 49.55 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 351 VGLVITDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLAVKSHG-IFETEHLCKDGRRLPVLL 429
Cdd:cd00130 3 DGVIVLDLDGR-ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPvTLEVRLRRKDGSVIWVLV 81
|
90 100
....*....|....*....|..
gi 1055322745 430 DITVIPDAEGRPLHRLTIVLNI 451
Cdd:cd00130 82 SLTPIRDEGGEVIGLLGVVRDI 103
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
762-873 |
2.75e-07 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 54.07 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 762 DASGLSIVMRNLLENAFKFSARAMP--PRIEISLREENHFAIVKITDNGIGFDMIYHDRIFEifQRLQRVEDYPGT-GVG 838
Cdd:PRK15053 429 DSTEFAAIVGNLLDNAFEASLRSDEgnKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE--QGVSTRADEPGEhGIG 506
|
90 100 110
....*....|....*....|....*....|....*
gi 1055322745 839 LALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:PRK15053 507 LYLIASYVTRCGGVITLEDNDPCGTLFSIFIPKVK 541
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
799-870 |
3.70e-07 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 49.69 E-value: 3.70e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1055322745 799 FAIVKITDNGIGFDMIYHDRIFEIFQRLQRVEDypGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16919 47 YVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGK--GTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
591-873 |
7.45e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 51.54 E-value: 7.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 591 GLFQTVKVPVFNVDGDVVGVLGI-ARDITALRQAEEDLRAINtgLEARVVERT---AEL-DilnkslesfvySVSHDLKA 665
Cdd:COG4585 5 ALLGALALLVGALLGLLLALVLLrARRAERAAELERELAARA--EEAREEERRriaRELhD-----------GVGQSLSA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 666 PLRGIEGYSQLLQEDYATALDDdgrlfIANIRNGVmcmGELIDDLLAYSRMERRKLDSNkLDLALMINQLLAEKAddiAA 745
Cdd:COG4585 72 IKLQLEAARRLLDADPEAAREE-----LEEIRELA---REALAELRRLVRGLRPPALDD-LGLAAALEELAERLL---RA 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 746 GGVEIRTDLATVWVQADASGLSIVMRNLLE---NAFKfsaRAMPPRIEISLREENHFAIVKITDNGIGFDmiyhdrifei 822
Cdd:COG4585 140 AGIRVELDVDGDPDRLPPEVELALYRIVQEaltNALK---HAGATRVTVTLEVDDGELTLTVRDDGVGFD---------- 206
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 823 fqrlqrVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPLAK 873
Cdd:COG4585 207 ------PEAAPGGGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPLAA 251
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
413-636 |
9.00e-07 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 52.75 E-value: 9.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 413 FETEHLCKDGRRLPVLLDITVIPDA----EGrplhrltIVLNISERKRIQRDLeSAQIQALQQqkearlailnqmqdana 488
Cdd:PRK13560 154 EEGHFRCGDGRFIDCCLRFERHAHAddqvDG-------FAEDITERKRAEERI-DEALHFLQQ----------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 489 arikaetalaalsdsearmrvLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRR 568
Cdd:PRK13560 209 ---------------------LLDNIADPAFWKDEDAKVFGCNDAACLACGFRREEIIGMSIHDFAPAQPADDYQEADAA 267
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055322745 569 ALETNVTIINEEWltFAETGYRGLFQTVKVPVFNVDGD---VVGVLGIARDITALRQAEEDLRAINTGLEA 636
Cdd:PRK13560 268 KFDADGSQIIEAE--FQNKDGRTRPVDVIFNHAEFDDKenhCAGLVGAITDISGRRAAERELLEKEDMLRA 336
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
505-571 |
1.25e-06 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 46.62 E-value: 1.25e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055322745 505 ARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDRRALE 571
Cdd:smart00091 1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
834-871 |
1.36e-06 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 52.11 E-value: 1.36e-06
10 20 30
....*....|....*....|....*....|....*...
gi 1055322745 834 GTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
655-871 |
1.94e-06 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 51.17 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 655 FVYSVSHDLKAPLRGIEGYSQLLQedyatalddDG-RLF----IANIRNGVMCMGELIDDLLAYSRMERRKLDSNK--LD 727
Cdd:PRK10549 243 FMADISHELRTPLAVLRGELEAIQ---------DGvRKFtpesVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKtpVD 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 728 LALMINQLLAEKADDIAAGGVEIRTDL---ATVWvqADASGLSIVMRNLLENAFKFSARamPPRIEISLREENHFAIVKI 804
Cdd:PRK10549 314 LVPLLEVAGGAFRERFASRGLTLQLSLpdsATVF--GDPDRLMQLFNNLLENSLRYTDS--GGSLHISAEQRDKTLRLTF 389
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1055322745 805 TDNGIGFDMIYHDRIFEIFQRLQ--RVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK10549 390 ADSAPGVSDEQLQKLFERFYRTEgsRNRASGGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPL 458
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
747-870 |
3.33e-06 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 50.54 E-value: 3.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 747 GVEIRTDLATVWVQADASGLSIVMRNLLENAFKFSaramPP--RIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQ 824
Cdd:PRK09835 357 GVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYT----PAgeAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFY 432
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1055322745 825 RL--QRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPgQGASFYLQLP 870
Cdd:PRK09835 433 RVdpSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
524-619 |
4.35e-06 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 45.92 E-value: 4.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 524 DGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLAdffHTNDRRALETNVTIINEEWLTFAETGYRGLFQTVKVPVFNV 603
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPED---SERLREALREGKAVREFEVVLYRKDGEPFPVLVSLAPIRDD 77
|
90
....*....|....*.
gi 1055322745 604 DGDVVGVLGIARDITA 619
Cdd:pfam13426 78 GGELVGIIAILRDITE 93
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-870 |
4.92e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 46.24 E-value: 4.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAfkfsARAMPPRI-EISLREENHFAI------------VKITDNGIGFDMIYHDRIFEIFQRlQRVEdypGT 835
Cdd:cd16918 4 VFLNLVRNA----AQALAGSGgEIILRTRTQRQVtlghprhrlalrVSVIDNGPGIPPDLQDTIFYPMVS-GREN---GT 75
|
90 100 110
....*....|....*....|....*....|....*
gi 1055322745 836 GVGLALVKKAIQRMGGKVWAESEPGQgASFYLQLP 870
Cdd:cd16918 76 GLGLAIAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-870 |
4.94e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 45.85 E-value: 4.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAMPPRIEISLR---EENHFAIVKITDNGIGFDMIYHDRIFEIFQRlQRVEdypGTGVGLALVKKA 845
Cdd:cd16920 4 VLINLVRNGIEAMSEGGCERRELTIRtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYT-TKSE---GLGMGLSICRSI 79
|
90 100
....*....|....*....|....*
gi 1055322745 846 IQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16920 80 IEAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
769-863 |
6.74e-06 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 49.63 E-value: 6.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAmpprIEISLRE-ENHFAIVkITDNGIGfdmIYHDRIFEIFQRLQRVEDY-PGTGVGLALVKKAI 846
Cdd:PRK10815 382 VMGNVLDNACKYCLEF----VEISARQtDEHLHIV-VEDDGPG---IPESKRELIFDRGQRADTLrPGQGLGLSVAREIT 453
|
90
....*....|....*..
gi 1055322745 847 QRMGGKVWAESEPGQGA 863
Cdd:PRK10815 454 EQYEGKISAGDSPLGGA 470
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
762-870 |
9.40e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 45.15 E-value: 9.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 762 DASGLSIVMRNLLENAFKFSARAmpPRIEISLREENHFAIVKITDNGIGFDmiyHDRIFEIFQRLQRVEDYP-----GTG 836
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTG--GKLRIRAAQTPQEVRLDVEDSAPGVS---DDQLARLFERFYRVESSRnrasgGSG 75
|
90 100 110
....*....|....*....|....*....|....
gi 1055322745 837 VGLALVKKAIQRMGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16946 76 LGLAICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
353-462 |
2.22e-05 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 48.52 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 353 LVITDARsncIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADLA---VKSHGIfETEHLCKDGRRLPVLL 429
Cdd:PRK09776 298 LVGTEGQ---WLQVNKALCQFLGYSQEELRGLTFQQLTWPEDLNKDLQQVEKLLsgeINSYSM-EKRYYRRDGEVVWALL 373
|
90 100 110
....*....|....*....|....*....|...
gi 1055322745 430 DITVIPDAEGRPLHRLTIVLNISERKRIQRDLE 462
Cdd:PRK09776 374 AVSLVRDTDGTPLYFIAQIEDINELKRTEQVNE 406
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
772-865 |
4.04e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 43.60 E-value: 4.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 772 NLLENAFKFSaramPP--RIEISLREENHFAIVKITDNGIGFDMIYHDRIFEIFQRLQRVED-YPGTGVGLALVKKAIQR 848
Cdd:cd16945 11 NLLDNAIDFS----PEggLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPRPHSgQKSTGLGLAFVQEVAQL 86
|
90
....*....|....*..
gi 1055322745 849 MGGKVWAESEPGQGASF 865
Cdd:cd16945 87 HGGRITLRNRPDGVLAF 103
|
|
| PRK10547 |
PRK10547 |
chemotaxis protein CheA; Provisional |
823-871 |
5.84e-05 |
|
chemotaxis protein CheA; Provisional
Pssm-ID: 236712 [Multi-domain] Cd Length: 670 Bit Score: 46.65 E-value: 5.84e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 1055322745 823 FQRLQRVEDYPGTGVGLALVKKAIQRMGGKVWAESEPGQGASFYLQLPL 871
Cdd:PRK10547 475 FSTAEQVTDVSGRGVGMDVVKRNIQEMGGHVEIQSKQGKGTTIRILLPL 523
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
514-617 |
1.03e-04 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 42.24 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 514 IPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADfFHTNDRRALETNVTIINEEWLTFAETGYRGLF 593
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDRE-ELRERLENLLSGGEPVTLEVRLRRKDGSVIWV 79
|
90 100
....*....|....*....|....
gi 1055322745 594 QTVKVPVFNVDGDVVGVLGIARDI 617
Cdd:cd00130 80 LVSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
242-319 |
3.07e-04 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 40.40 E-value: 3.07e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1055322745 242 NVRFEQLFGYSAADMPTLAEWCRRAYPdPVYRAEV-EAIWNTAVAGSVEStdsidaGEFRISCKDGQQRIMHIHSIALK 319
Cdd:pfam08447 5 SPRFEEILGYTPEELLGKGESWLDLVH-PDDRERVrEALWEALKGGEPYS------GEYRIRRKDGEYRWVEARARPIR 76
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
767-868 |
5.98e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 40.12 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 767 SIVMRNLLENAFK--FSARAMPPRIEISLREENHFAIVKITDNGIGFDMIyhdrifeIFQRLQRVEDyPGTGVGLALVKK 844
Cdd:cd16924 3 PFTLQPLVENAIQhgLSPLTDKGVVTISALKEDNHVMIEVEDNGRGIDPK-------VLNILGKKPK-EGNGIGLYNVHQ 74
|
90 100
....*....|....*....|....*....
gi 1055322745 845 AI-----QRMGGKVWAESEPGQGASFYLQ 868
Cdd:cd16924 75 RLillfgEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
769-870 |
6.22e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 39.46 E-value: 6.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 769 VMRNLLENAFKFSARAmppRIEISLREENHFAIVKITDNGIGFDMIYHDrifeifqrlqrvedyPGTGVGLALVKKAIQR 848
Cdd:cd16917 4 IVQEALTNALKHAGAS---RVRVTLSYTADELTLTVVDDGVGFDGPAPP---------------GGGGFGLLGMRERAEL 65
|
90 100
....*....|....*....|..
gi 1055322745 849 MGGKVWAESEPGQGASFYLQLP 870
Cdd:cd16917 66 LGGTLTIGSRPGGGTRVTARLP 87
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
346-443 |
1.15e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 39.32 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 346 FEQTQVGLVITDArSNCIVSVNSAFALERGYTC-EAMRQMPLAQLFPPDCKTDVQQMLADLAVKSHG-IFETEHLCKDGR 423
Cdd:pfam00989 7 LESLPDGIFVVDE-DGRILYVNAAAEELLGLSReEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESrGFEVSFRVPDGR 85
|
90 100
....*....|....*....|
gi 1055322745 424 RLPVLLDITVIPDAEGRPLH 443
Cdd:pfam00989 86 PRHVEVRASPVRDAGGEILG 105
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
222-334 |
2.34e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 38.55 E-value: 2.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 222 FQKAPLAMGLVDKQGIIQDQNVRFEQLFGYSAADMptLAEWCRRAYPDPVyRAEVEAIWNTAVAGsvesTDSIDAGEFRI 301
Cdd:pfam08448 1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPEEL--LGKTLAELLPPED-AARLERALRRALEG----EEPIDFLEELL 73
|
90 100 110
....*....|....*....|....*....|....*....
gi 1055322745 302 SckDGQQRIMHIHSIALKE------GLLTTFMDVTERRR 334
Cdd:pfam08448 74 L--NGEERHYELRLTPLRDpdgeviGVLVISRDITERRR 110
|
|
| PAS_7 |
pfam12860 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
231-336 |
2.44e-03 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 432837 [Multi-domain] Cd Length: 115 Bit Score: 38.67 E-value: 2.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 231 LVDKQGIIQDQNVRFEQLFGYSAADM-------PTLAEWCRRAYPDPvyrAEVEAiwntAVAGSVESTDSIDAGEFRISC 303
Cdd:pfam12860 10 VFDADLRLVAWNRRYRELLDLPEDLVqvgvpfeEIIRYNAERGEYGP---GDVEA----HVRRRLAAARAGSPHYFERER 82
|
90 100 110
....*....|....*....|....*....|....
gi 1055322745 304 KDGqqRIMHIHSIALKE-GLLTTFMDVTERRRSE 336
Cdd:pfam12860 83 PDG--RVIEIRGNPLPDgGFVTTFTDITERRRAE 114
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
234-334 |
2.81e-03 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 41.58 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 234 KQGIIQDQnvRFEQLFGYSAADMPTLAEWCRRAYPDPVYRAEVEaiwntaVAGSVESTDSIDAgEFRISCKDGqqrIMHI 313
Cdd:PRK09776 430 PNIISWDK--RMFELYEIPPHIKPTWQVWYACLHPEDRQRVEKE------IRDALQGRSPFKL-EFRIVVKDG---VRHI 497
|
90 100
....*....|....*....|....*....
gi 1055322745 314 HSIAL----KEG----LLTTFMDVTERRR 334
Cdd:PRK09776 498 RALANrvlnKDGeverLLGINMDMTEVRQ 526
|
|
| HATPase_c_5 |
pfam14501 |
GHKL domain; This family represents the structurally related ATPase domains of histidine ... |
766-869 |
3.04e-03 |
|
GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433996 [Multi-domain] Cd Length: 102 Bit Score: 37.97 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 766 LSIVMRNLLENAFKFSARAMPPR-IEISLREENHFAIVKItDNGIGFDMIYHDRIFEifqrlqRVEDYPGTGVGLALVKK 844
Cdd:pfam14501 6 LCVIFGNLLDNAIEACSKIDDNRfIRLKIREKQNFLIIRI-ENTYEGELKFEGKLPS------TKTKGDGHGIGLKSIRR 78
|
90 100
....*....|....*....|....*
gi 1055322745 845 AIQRMGGKVWAESEPGqgaSFYLQL 869
Cdd:pfam14501 79 IVKKYGGNLSTEIENG---IFTLSI 100
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
505-567 |
3.21e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 36.76 E-value: 3.21e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1055322745 505 ARMRVLINTIPDLIWLKNVDGIYLQCNAAFERYYGKPEVDILGHTDYDFVNADLADFFHTNDR 567
Cdd:pfam13188 1 ERLRALFESSPDGILVLDEGGRIIYVNPAALELLGYELLGELLGELLDLLDPLLEDALELLRE 63
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
346-405 |
8.63e-03 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 35.84 E-value: 8.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055322745 346 FEQTQVGLVITDARSNcIVSVNSAFALERGYTCEAMRQMPLAQLFPPDCKTDVQQMLADL 405
Cdd:smart00091 7 LESLPDGIFVLDLDGR-ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRL 65
|
|
| |
