NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1055643900|ref|WP_067283768|]
View 

AraC family transcriptional regulator [Mitsuaria sp. 7]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 11677403)

AraC family transcriptional regulator containing an AraC family helix-turn-helix (HTH) DNA-binding domain, may regulate the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|15808743|9409145|33837749|11282467

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Arabinose_bd super family cl14988
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 20-214 4.14e-25

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


The actual alignment was detected with superfamily member pfam12625:

Pssm-ID: 432679  Cd Length: 185  Bit Score: 100.02  E-value: 4.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  20 GLDVDVVAARAGIPAGFTRRPGTGLDTRQFFAFWRAVAELSGDPLIGLKIGGEVGPSQLEAVSVAALHSATFGDALARLA 99
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 100 RYKGLccpeevrveRSSAGGSGKGESAGERdlARLSFHWILAKESCPTIISDAAFASAHALARVGTGRTVVPHRLELMR- 178
Cdd:pfam12625  81 RYLRL---------LSDALELRLEEGEGGL--ARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHp 149

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1055643900 179 MPSDTAPYASYFGCEVRTGCVGDALVYDAEALDLPF 214
Cdd:pfam12625 150 APADAAEYERLFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 4.05e-22

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  257 RPTIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1055643900  336 AQWR 339
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 20-214 4.14e-25

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 100.02  E-value: 4.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  20 GLDVDVVAARAGIPAGFTRRPGTGLDTRQFFAFWRAVAELSGDPLIGLKIGGEVGPSQLEAVSVAALHSATFGDALARLA 99
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 100 RYKGLccpeevrveRSSAGGSGKGESAGERdlARLSFHWILAKESCPTIISDAAFASAHALARVGTGRTVVPHRLELMR- 178
Cdd:pfam12625  81 RYLRL---------LSDALELRLEEGEGGL--ARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHp 149

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1055643900 179 MPSDTAPYASYFGCEVRTGCVGDALVYDAEALDLPF 214
Cdd:pfam12625 150 APADAAEYERLFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 4.05e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  257 RPTIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1055643900  336 AQWR 339
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
162-346 1.37e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 162 RVGTGRTVVPHRLELMRMPSDTAPYASYFGCEVRTGCVGDALVYDAEALDLPFVTRNEDLLAVLVPALDAQLDAMGEVDI 241
Cdd:COG2207    77 LLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 242 ETQARSVLMKMMRgdrpTIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEA 320
Cdd:COG2207   157 LLLLLLLLLLLLL----TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQ 232

                         170       180
                  ....*....|....*....|....*.
gi 1055643900 321 NSFQRAFRRWEGRTPAQWREQQGSEE 346
Cdd:COG2207   233 SHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
263-341 2.04e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.18  E-value: 2.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 263 LARALNMSARSLQRRL-GEAGTSYQGVLDHVRLETARRLLAD-TAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQWRE 340
Cdd:pfam12833   1 LAAALGMSPRTLSRLFkRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1055643900 341 Q 341
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 255-345 7.42e-14

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 71.34  E-value: 7.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 255 GDRPTIDTLARALNMSARSLQRR-LGEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGR 333
Cdd:COG4977   224 EEPLSVDELARRAGMSPRTLERRfRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGV 303

                          90
                  ....*....|..
gi 1055643900 334 TPAQWREQQGSE 345
Cdd:COG4977   304 SPSAYRRRFRAR 315
ftrA PRK09393
transcriptional activator FtrA; Provisional
 249-344 1.17e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 64.99  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 249 LMKMMRGD--RP-TIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQ 324
Cdd:PRK09393  223 LIDWMRAHlaEPhTVASLAARAAMSPRTFLRRFEAAtGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                          90       100
                  ....*....|....*....|
gi 1055643900 325 RAFRRWEGRTPAQWREQQGS 344
Cdd:PRK09393  303 HHFRRRAATSPAAYRKRFGR 322
 
Name Accession Description Interval E-value
Arabinose_bd pfam12625
Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial ...
 20-214 4.14e-25

Arabinose-binding domain of AraC transcription regulator, N-term; AraC is a bacterial transcriptional regulatory protein with a DNA-binding domain at the C-terminus, HTH_AraC, pfam00165, and this dimerization domain which harbours the arabinose-binding pocket at the N-terminus. AraC positively and negatively regulates expression of the proteins required for the uptake and catabolism of the sugar L-arabinose 1,2,3].


Pssm-ID: 432679  Cd Length: 185  Bit Score: 100.02  E-value: 4.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  20 GLDVDVVAARAGIPAGFTRRPGTGLDTRQFFAFWRAVAELSGDPLIGLKIGGEVGPSQLEAVSVAALHSATFGDALARLA 99
Cdd:pfam12625   1 GLDPAALLRRAGLDPALLADPDARVPLDQYLRLWEAAARELGDPALGLRLGRRLRPGSLGLLGYAALSSPTLGEALDRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 100 RYKGLccpeevrveRSSAGGSGKGESAGERdlARLSFHWILAKESCPTIISDAAFASAHALARVGTGRTVVPHRLELMR- 178
Cdd:pfam12625  81 RYLRL---------LSDALELRLEEGEGGL--ARLRLDVRPIPGRRRDFLLELALAALLRLARWLLGRRLPPLRVEFPHp 149

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1055643900 179 MPSDTAPYASYFGCEVRTGCVGDALVYDAEALDLPF 214
Cdd:pfam12625 150 APADAAEYERLFGCPVRFGAPRNALVFDAADLDRPL 185
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
257-339 4.05e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 4.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900  257 RPTIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTP 335
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKEtGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 1055643900  336 AQWR 339
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
162-346 1.37e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 162 RVGTGRTVVPHRLELMRMPSDTAPYASYFGCEVRTGCVGDALVYDAEALDLPFVTRNEDLLAVLVPALDAQLDAMGEVDI 241
Cdd:COG2207    77 LLGLLLLALLALLLLVGLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLL 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 242 ETQARSVLMKMMRgdrpTIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEA 320
Cdd:COG2207   157 LLLLLLLLLLLLL----TLEELARELGLSPRTLSRLFKEEtGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQ 232

                         170       180
                  ....*....|....*....|....*.
gi 1055643900 321 NSFQRAFRRWEGRTPAQWREQQGSEE 346
Cdd:COG2207   233 SHFSRAFKKRFGVTPSEYRKRLRARA 258
HTH_18 pfam12833
Helix-turn-helix domain;
263-341 2.04e-20

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 84.18  E-value: 2.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 263 LARALNMSARSLQRRL-GEAGTSYQGVLDHVRLETARRLLAD-TAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQWRE 340
Cdd:pfam12833   1 LAAALGMSPRTLSRLFkRELGLSPKEYLRRLRLERARRLLLEdTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 1055643900 341 Q 341
Cdd:pfam12833  81 R 81
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 255-345 7.42e-14

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 71.34  E-value: 7.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 255 GDRPTIDTLARALNMSARSLQRR-LGEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGR 333
Cdd:COG4977   224 EEPLSVDELARRAGMSPRTLERRfRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGV 303

                          90
                  ....*....|..
gi 1055643900 334 TPAQWREQQGSE 345
Cdd:COG4977   304 SPSAYRRRFRAR 315
ftrA PRK09393
transcriptional activator FtrA; Provisional
 249-344 1.17e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 64.99  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 249 LMKMMRGD--RP-TIDTLARALNMSARSLQRRLGEA-GTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQ 324
Cdd:PRK09393  223 LIDWMRAHlaEPhTVASLAARAAMSPRTFLRRFEAAtGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLR 302

                          90       100
                  ....*....|....*....|
gi 1055643900 325 RAFRRWEGRTPAQWREQQGS 344
Cdd:PRK09393  303 HHFRRRAATSPAAYRKRFGR 322
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 256-348 1.44e-07

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 52.36  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 256 DRPTIDTLARALNMSARSLQRRL-GEAGTSYQGVLDHVRLETARRLLaDTAFSPGEIAFFLGFEEANSFQRAFRRWEGRT 334
Cdd:COG2169    99 DRPSLEDLAARLGLSPRHLRRLFkAHTGVTPKAYARARRLLRARQLL-QTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMT 177

                          90
                  ....*....|....
gi 1055643900 335 PAQWREQQGSEELR 348
Cdd:COG2169   178 PSAYRRGGAGAAIR 191
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
211-339 3.50e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 50.82  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 211 DLPfVTRNEDLLAVLVPALDAQLDAMGEVDIETQARSVLMKMMRgdrptidtlaralnmsarslQRRLGEAGTSYQGVLD 290
Cdd:PRK13502  168 DLP-ATSRETLLDKLITALANSLECPFALDAFCQQEQCSERVLR--------------------QQFRAQTGMTINQYLR 226

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1055643900 291 HVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQWR 339
Cdd:PRK13502  227 QVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 259-345 2.28e-06

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 48.38  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 259 TIDTLARALNMSARSLQRRLGEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQW 338
Cdd:PRK09978  160 TLARIASELLMSPSLLKKKLREEETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTEY 239


                  ....*..
gi 1055643900 339 REQQGSE 345
Cdd:PRK09978  240 QERSAQG 246
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 259-338 1.69e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 45.83  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 259 TIDTLARALNMSARSLQRRLGEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQW 338
Cdd:PRK15186  199 ALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEF 278
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 195-341 2.13e-05

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 45.79  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 195 RTGCVGDAlvyDAEALdlpfvtrNEDLLAVLVPALDAQLDAMGEVDIETQ-ARSVLMKMMRGDRPTIDTLARALNMSARS 273
Cdd:PRK09685  161 NGPALSET---ESEAL-------LEALIALLRPALHQRESVQPRRERQFQkVVALIDQSIQEEILRPEWIAGELGISVRS 230

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1055643900 274 LQRRLGEAGTSYQGVLDHVRLE---TARRLLADTAfSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQWREQ 341
Cdd:PRK09685  231 LYRLFAEQGLVVAQYIRNRRLDrcaDDLRPAADDE-KITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRK 300
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
261-341 2.29e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 45.44  E-value: 2.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 261 DTLARALNMSARSLQRRLGE-AGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQWR 339
Cdd:PRK13503  191 EALADQFSLSLRTLHRQLKQqTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIR 270


                  ..
gi 1055643900 340 EQ 341
Cdd:PRK13503  271 QG 272
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 260-336 5.03e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 44.60  E-value: 5.03e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1055643900 260 IDTLARALNMSARSLQRRLGEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPA 336
Cdd:PRK15185  225 LTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPS 301
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
260-339 3.79e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 42.01  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 260 IDTLARALNMSARSLQRRL-GEAGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGFEEANSFQRAFRRWEGRTPAQW 338
Cdd:PRK13500  225 LDKFCDEASCSERVLRQQFrQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPSQW 304


                  .
gi 1055643900 339 R 339
Cdd:PRK13500  305 R 305
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
248-341 6.10e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 41.04  E-value: 6.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 248 VLMKMMRGDrptidtLARALNMSARSLQRRLGE----------AGTSYQGVLDHVRLETARRLLADTAFSPGEIAFFLGF 317
Cdd:PRK13501  180 LIMSALQQS------LGAYFDMADFCHKNQLVErslkqlfrqqTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGF 253

                          90       100
                  ....*....|....*....|....
gi 1055643900 318 EEANSFQRAFRRWEGRTPAQWREQ 341
Cdd:PRK13501  254 EDSNYFSAVFTREAGMTPRDYRQR 277
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
256-341 4.51e-03

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 36.44  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055643900 256 DRP-TIDTLARALNMSARSLQRRLgeAGTSYQGVLDHVRletARRL-LADTAFSPGE-----IAFFLGFEEANSFQRAFR 328
Cdd:PRK10219   19 DQPlNIDVVAKKSGYSKWYLQRMF--RTVTHQTLGDYIR---QRRLlLAAVELRTTErpifdIAMDLGYVSQQTFSRVFR 93

                          90
                  ....*....|...
gi 1055643900 329 RWEGRTPAQWREQ 341
Cdd:PRK10219   94 RQFDRTPSDYRHR 106
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 309-339 5.83e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.44  E-value: 5.83e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1055643900 309 GEIAFFLGFEEaNSFQRAFRRWEGRTPAQWR 339
Cdd:pfam00165  12 ADIADELGFSR-SYFSRLFKKYTGVTPSQYR 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH