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Conserved domains on  [gi|1055940221|ref|WP_067482655|]
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MULTISPECIES: amino acid ABC transporter permease [Enterococcus]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-213 1.34e-77

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.89  E-value: 1.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:COG0765     8 LLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILG 163
Cdd:COG0765    88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1055940221 164 LGDVMRAGKIAMERD-ASLLPLLGVAGIYLALTGILTLIMKQVEEKLNYYR 213
Cdd:COG0765   168 VPELTRAAQQIASRTfRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-213 1.34e-77

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.89  E-value: 1.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:COG0765     8 LLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILG 163
Cdd:COG0765    88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1055940221 164 LGDVMRAGKIAMERD-ASLLPLLGVAGIYLALTGILTLIMKQVEEKLNYYR 213
Cdd:COG0765   168 VPELTRAAQQIASRTfRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
4-210 6.57e-39

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 133.34  E-value: 6.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:PRK15100    8 VIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILG 163
Cdd:PRK15100   88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1055940221 164 LGDVMRAGKIAMERDASLLPL-LGVAGIYLALTGILTLIMKQVEEKLN 210
Cdd:PRK15100  168 VPELFRQAQLITSRTLEVFTMyLAASLIYWIMATVLSALQNRFENQLN 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 5-209 1.27e-35

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 124.58  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   5 IEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDRF 84
Cdd:TIGR03003   7 RQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  85 EAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGL 164
Cdd:TIGR03003  87 VAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1055940221 165 GDVM-RAGKIAMERDASLLPLLGVAGIYLALTGILTLIMKQVEEKL 209
Cdd:TIGR03003 167 LELMnQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 15-200 3.64e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 81.17  E-value: 3.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  15 ALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIG---IVFDRFEAALLAF 91
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  92 VLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGLGDVMRAG 171
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1055940221 172 KIAMERDASLLP-LLGVAGIYLALTGILTL 200
Cdd:cd06261   161 TGLLLIFAILFPgDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 29-209 4.00e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 67.71  E-value: 4.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  29 SLPLGLILALGLSlnfKPIRYLLQTYVWVMRGTPLLLQLIFVFYgLPTIGIVFDRFEAALLAFVLNYAAYFAEIFRGGIQ 108
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221 109 SIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYIL----GLGDVMRAGKIAMERDASLLPL 184
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 1055940221 185 LGVAGIYLALTGILTLIMKQVEEKL 209
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 4-213 1.34e-77

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.89  E-value: 1.34e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:COG0765     8 LLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLLGIDLSP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILG 163
Cdd:COG0765    88 FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIG 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1055940221 164 LGDVMRAGKIAMERD-ASLLPLLGVAGIYLALTGILTLIMKQVEEKLNYYR 213
Cdd:COG0765   168 VPELTRAAQQIASRTfRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 4-210 1.53e-56

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 178.75  E-value: 1.53e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:COG4160     6 LFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYGLGQFEWVRES 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 F------EA---ALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVK 154
Cdd:COG4160    86 WlwpllrDPwfcALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYSNEVILMLK 165

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1055940221 155 DSSLVYILGLGDVMRAGKIAMERD-ASLLPLLGVAGIYLALTGILTLIMKQVEEKLN 210
Cdd:COG4160   166 ATALASTITVMDLTGVARRIYSRTyDPFEPFLIAALIYLVITFLLTRLFRLLERRLL 222
PRK15100 PRK15100
cystine ABC transporter permease;
4-210 6.57e-39

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 133.34  E-value: 6.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   4 LIEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDR 83
Cdd:PRK15100    8 VIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQFGIELDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILG 163
Cdd:PRK15100   88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1055940221 164 LGDVMRAGKIAMERDASLLPL-LGVAGIYLALTGILTLIMKQVEEKLN 210
Cdd:PRK15100  168 VPELFRQAQLITSRTLEVFTMyLAASLIYWIMATVLSALQNRFENQLN 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 5-209 1.27e-35

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 124.58  E-value: 1.27e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   5 IEVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDRF 84
Cdd:TIGR03003   7 RQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIRLPAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  85 EAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGL 164
Cdd:TIGR03003  87 VAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITV 166

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1055940221 165 GDVM-RAGKIAMERDASLLPLLGVAGIYLALTGILTLIMKQVEEKL 209
Cdd:TIGR03003 167 LELMnQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEARL 212
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 8-209 5.71e-33

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 118.23  E-value: 5.71e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   8 MPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTI--GIVFDRFE 85
Cdd:PRK09494   12 IPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMAfnDLRIDPFT 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  86 AALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGLG 165
Cdd:PRK09494   92 AAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVA 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1055940221 166 DVMRAGKIAMERDASLLPLL-GVAGIYLALTGILTLIMKQVEEKL 209
Cdd:PRK09494  172 ELTRQGQEIIAGNFRALEIWsAVAVIYLIITLVLSFILRRLERRM 216
artM PRK11122
arginine ABC transporter permease ArtM;
6-208 4.05e-31

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 113.13  E-value: 4.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   6 EVMPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYG---LPTI----- 77
Cdd:PRK11122    3 EYLPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGpgqFPWLqeypw 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  78 --GIVFDRFEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVtKIVIPQVIKIVLPSVGNEVINLVKD 155
Cdd:PRK11122   83 lwHLLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTL-RILLPYAFKRALSSYSNEVVLVFKS 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1055940221 156 SSLVYILGLGDVMRAGKIAMERDASLLpLLGVAG-IYLALTGILTLIMKQVEEK 208
Cdd:PRK11122  162 TSLAYTITLMDVMGYSQLLYGRTYDVM-VFGAAGiIYLVVNGLLTLLMRLIERK 214
PRK15069 PRK15069
histidine ABC transporter permease HisM;
26-206 1.86e-26

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 101.67  E-value: 1.86e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  26 LVGSLPLGLILALGLSL----NFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIV--------FDR--FEAALLAF 91
Cdd:PRK15069   30 LVASVVIGFVLAVPLAIarvsSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSLEIVrgtdlldaFFRsgLNCTILAF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  92 VLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGLGDVMrag 171
Cdd:PRK15069  110 TLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATVPDIL--- 186

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1055940221 172 KIAmeRD---ASLLPL--LGVAG-IYLALTGILTLIMKQVE 206
Cdd:PRK15069  187 KIA--RDinsATYQPFqaFGIAAvLYLIISFVLISLFRRAE 225
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 8-105 4.05e-26

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 96.83  E-value: 4.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   8 MPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIGIVFDRFEAA 87
Cdd:TIGR01726   2 LPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIRLSPLTAA 81

                          90
                  ....*....|....*...
gi 1055940221  88 LLAFVLNYAAYFAEIFRG 105
Cdd:TIGR01726  82 VIALTLFYGAYLAEIFRG 99
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
11-208 1.59e-24

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 96.67  E-value: 1.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  11 LLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYG----------------- 73
Cdd:PRK11123    7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYFGssqllltlsdgftlnlg 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  74 -------LPTIGIVFDRFEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVG 146
Cdd:PRK11123   87 fvqipvqMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1055940221 147 NEVINLVKDSSLVYILGLGDVMRAGK-IAMERDASLLPLLGVAGIYLALTGILTLIMKQVEEK 208
Cdd:PRK11123  167 NQWLVLLKDTALVSLISVNDLMLQTKsIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
8-189 6.87e-22

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 89.12  E-value: 6.87e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   8 MPQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTI-----GIVFD 82
Cdd:PRK15107   13 LPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFlqnvlGLSPK 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  83 ---RFEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLV 159
Cdd:PRK15107   93 tdiRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172

                         170       180       190
                  ....*....|....*....|....*....|
gi 1055940221 160 YILGLGDVMRAGKIAMERDASLLPLLGVAG 189
Cdd:PRK15107  173 YVLSLADFFRTASTIGERDGTQVEMILFAG 202
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
11-174 1.93e-20

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 85.62  E-value: 1.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  11 LLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLP--------TIG---I 79
Cdd:PRK15135    9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPDLVLMLLIFYGLQialnsvteALGvgqI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  80 VFDRFEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLV 159
Cdd:PRK15135   89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                         170
                  ....*....|....*
gi 1055940221 160 YILGLGDVMRAGKIA 174
Cdd:PRK15135  169 SLLGLEDVVKATQLA 183
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 15-200 3.64e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 81.17  E-value: 3.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  15 ALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYVWVMRGTPLLLQLIFVFYGLPTIG---IVFDRFEAALLAF 91
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLgwgILPGLGLPALILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  92 VLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYILGLGDVMRAG 171
Cdd:cd06261    81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                         170       180       190
                  ....*....|....*....|....*....|
gi 1055940221 172 KIAMERDASLLP-LLGVAGIYLALTGILTL 200
Cdd:cd06261   161 TGLLLIFAILFPgDLGVAAAVALILLLLSL 190
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 84-158 3.35e-17

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 78.65  E-value: 3.35e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1055940221  84 FEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSL 158
Cdd:COG4597   265 FVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNSSL 339
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 29-209 4.00e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 67.71  E-value: 4.00e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221  29 SLPLGLILALGLSlnfKPIRYLLQTYVWVMRGTPLLLQLIFVFYgLPTIGIVFDRFEAALLAFVLNYAAYFAEIFRGGIQ 108
Cdd:pfam00528   1 GIPLGIIAALRRG---RRLDRLLRPLIDLLQALPSFVLAILLVV-IAILSILGHGILPAIILALLGWAGYARLIRRAALR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221 109 SIPQGQYEAAQVLQFSPFQTVTKIVIPQVIKIVLPSVGNEVINLVKDSSLVYIL----GLGDVMRAGKIAMERDASLLPL 184
Cdd:pfam00528  77 SLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgswpGLGLLLIEAILGYDYPEIQGPV 156

                         170       180
                  ....*....|....*....|....*
gi 1055940221 185 LGVAGIYLALTGILTLIMKQVEEKL 209
Cdd:pfam00528 157 LAAALILLLLNLLVDILQRLLDPRV 181
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
9-137 6.62e-05

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 42.81  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   9 PQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQTYV---------------WVMRGTPLLLQLIFVFYG 73
Cdd:COG1175    72 PRFWNALGNTLLFTVVSVPLQLVLGLLLALLLNRKLRGRGFFRTLFFlpwvispvvvaliwkWLFNPDYGLLNALLGALG 151

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1055940221  74 LPTIGIVFDRfEAALLAFVL----NYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQV 137
Cdd:COG1175   152 LEPINWLGDP-SLALPAVIIvtvwKGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLL 218
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
9-137 8.81e-04

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 39.76  E-value: 8.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1055940221   9 PQLLVGALTTLKLFCLTLVGSLPLGLILALGLSLNFKPIRYLLQT--------------YVWVM--RGTPLLLQLIFVFY 72
Cdd:COG1178    50 PYLWRALGNTLLLALLVTLLSLLLGVPLAWLLARTDFPGRRLLRWllllplalppyvvaLAWIAlfGPNGLLNTLLRALF 129

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1055940221  73 GLPTIGIvfDRFEAALLAFVLNYAAYFAEIFRGGIQSIPQGQYEAAQVLQFSPFQTVTKIVIPQV 137
Cdd:COG1178   130 GLEPPDI--YGLGGIILVLVLFNYPYVYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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