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Conserved domains on  [gi|1056439065|ref|WP_067880905|]
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tautomerase family protein [Agromyces aureus]

Protein Classification

tautomerase family protein( domain architecture ID 1755)

tautomerase family protein similar to Homo sapiens macrophage migration inhibitory factor and D-dopachrome decarboxylase-like protein

CATH:  3.30.429.10
Gene Ontology:  GO:0006725|GO:0016853
PubMed:  29184004|12051677|18695941
SCOP:  3001770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
4Oxalocrotonate_Tautomerase super family cl00235
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 38-115 1.58e-17

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


The actual alignment was detected with superfamily member pfam14552:

Pssm-ID: 444774  Cd Length: 82  Bit Score: 71.44  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056439065  38 DRNVRLIAHAPHRFACSPD---VTQPEYRTLVTIDCFSGRSVDAKRALYAAIVERLEP-LGIPRDHVSTIVHDIPRESWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1056439065 114 LS 115
Cdd:pfam14552  81 FG 82
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-115 1.58e-17

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 71.44  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056439065  38 DRNVRLIAHAPHRFACSPD---VTQPEYRTLVTIDCFSGRSVDAKRALYAAIVERLEP-LGIPRDHVSTIVHDIPRESWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1056439065 114 LS 115
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 65-120 2.51e-11

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 54.77  E-value: 2.51e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1056439065  65 LVTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSGGLAA 120
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGIGGKLLS 58
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 68-118 9.83e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 43.17  E-value: 9.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1056439065  68 IDCFSGRSVDAKRALYAAIVE-RLEPLGIPRDHVSTIVHDIPRESWGLSGGL 118
Cdd:PRK00745    6 IELFEGRTVEQKRKLVEEITRvTVETLGCPPESVDIIITDVKRENWATGGKL 57
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 66-120 5.79e-06

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 41.22  E-value: 5.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1056439065  66 VTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSGGLAA 120
Cdd:cd00491     3 VQIYILEGRTDEQKRELIERVTEAVsEILGAPEATIVVIIDEMPKENWGIGGESAS 58
 
Name Accession Description Interval E-value
Tautomerase_2 pfam14552
Tautomerase enzyme;
38-115 1.58e-17

Tautomerase enzyme;


Pssm-ID: 434035  Cd Length: 82  Bit Score: 71.44  E-value: 1.58e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056439065  38 DRNVRLIAHAPHRFACSPD---VTQPEYRTLVTIDCFSGRSVDAKRALYAAIVERLEP-LGIPRDHVSTIVHDIPRESWG 113
Cdd:pfam14552   1 DRFQIIHEHDPEDFVYPPTylgIERSDDYVIIQITLFAGRSVEQKKALYRALAERLAAkLGIRPEDVFIVLVENPKENWS 80


                  ..
gi 1056439065 114 LS 115
Cdd:pfam14552  81 FG 82
PptA COG1942
Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites ...
 65-120 2.51e-11

Phenylpyruvate tautomerase PptA, 4-oxalocrotonate tautomerase family [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441545  Cd Length: 58  Bit Score: 54.77  E-value: 2.51e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1056439065  65 LVTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSGGLAA 120
Cdd:COG1942     2 IINIKLFEGRTPEQKRALAKAVTDAVvEVLGKPPESVSVVIEEVPPENWGIGGKLLS 58
Tautomerase pfam01361
Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that ...
 65-116 3.03e-08

Tautomerase enzyme; This family includes the enzyme 4-oxalocrotonate tautomerase that catalyzes the ketonization of 2-hydroxymuconate to 2-oxo-3-hexenedioate.


Pssm-ID: 396090  Cd Length: 60  Bit Score: 46.90  E-value: 3.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1056439065  65 LVTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSG 116
Cdd:pfam01361   2 FVNIKLFEGRTDEQKKELIERVTDALvEVLGAPRSAIVVIIEEVPPENWGVGG 54
PRK00745 PRK00745
4-oxalocrotonate tautomerase; Provisional
 68-118 9.83e-07

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 179107  Cd Length: 62  Bit Score: 43.17  E-value: 9.83e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1056439065  68 IDCFSGRSVDAKRALYAAIVE-RLEPLGIPRDHVSTIVHDIPRESWGLSGGL 118
Cdd:PRK00745    6 IELFEGRTVEQKRKLVEEITRvTVETLGCPPESVDIIITDVKRENWATGGKL 57
4Oxalocrotonate_Tautomerase cd00491
4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The ...
 66-120 5.79e-06

4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one dimer and the third from a neighboring monomer. Each monomer is a beta-alpha-beta fold with two small beta strands at the C-terminus that fold back on themselves. A pair of monomers form a dimer with two-fold symmetry, consisting of a 4-stranded beta sheet with two helices on one side and two additional small beta strands at each end. The dimers are assembled around a 3-fold axis of rotation to form a hexamer, with the short beta strands from each dimer contacting the neighboring dimers.


Pssm-ID: 238274  Cd Length: 58  Bit Score: 41.22  E-value: 5.79e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1056439065  66 VTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSGGLAA 120
Cdd:cd00491     3 VQIYILEGRTDEQKRELIERVTEAVsEILGAPEATIVVIIDEMPKENWGIGGESAS 58
PRK02220 PRK02220
4-oxalocrotonate tautomerase; Provisional
 65-120 7.06e-03

4-oxalocrotonate tautomerase; Provisional


Pssm-ID: 235013  Cd Length: 61  Bit Score: 32.81  E-value: 7.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1056439065  65 LVTIDCFSGRSVDAKRALYAAIVERL-EPLGIPRDHVSTIVHDIPRESWGLSGGLAA 120
Cdd:PRK02220    3 YVHIKLIEGRTEEQLKALVKDVTAAVsKNTGAPAEHIHVIINEMSKNHYAVGGKRLS 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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