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MULTISPECIES: NADP-dependent malic enzyme [Sulfitobacter]
Protein Classification
NADP-dependent malic enzyme ( domain architecture ID 11486247 )
NADP-dependent malic enzyme catalyzes the conversion of (S)-malate to pyruvate and carbon dioxide using NADP as a cofactor
List of domain hits
Name
Accession
Description
Interval
E-value
PRK12862
PRK12862 malic enzyme; Reviewed
1-757
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1393.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M S DTPN LR Q AALDYH EH P R PGK L E VRA TKPLAN G RDLA R AYSPGVA EA C I EI KN DP DT AARYTSRGNLVAVV T NGTAVLG 80
Cdd:PRK12862 5 A S AKAE LR E AALDYH RF P T PGK I E IAP TKPLAN Q RDLA L AYSPGVA AP C L EI AA DP AN AARYTSRGNLVAVV S NGTAVLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LGNIG A LASKPVMEGKAVLFKKFA N ID C FDIELD QA DP E KL A EIV C A M EP S FG A INLEDIKAP D CF VV E KIC RERM N IPV 160
Cdd:PRK12862 85 LGNIG P LASKPVMEGKAVLFKKFA G ID V FDIELD ES DP D KL V EIV A A L EP T FG G INLEDIKAP E CF YI E REL RERM K IPV 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAI V V G AA AK N A L HVA GK KF ED I K I V ST G G GAA GI ACL NM L LK LGVKREN V W LC DI N G L VYEGRTE D M N P S KA 240
Cdd:PRK12862 165 FHDDQHGTAI I V A AA LL N G L KLV GK DI ED V K L V AS G A GAA AL ACL DL L VS LGVKREN I W VT DI K G V VYEGRTE L M D P W KA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 E YAQK S D L RTL DD VI D GAD L FLGLS GP GVL S PEMV A KMA K RP I IFALANPTPEILP DL ARAV A PDAIIATGRSD F PNQVN 320
Cdd:PRK12862 245 R YAQK T D A RTL AE VI E GAD V FLGLS AA GVL K PEMV K KMA P RP L IFALANPTPEILP EE ARAV R PDAIIATGRSD Y PNQVN 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVLCFP F IFRGALDVGATTIN D EMKIA CIDG IA A LAR ATT S AEA AAAY Q GE Q L T FG AE YLIPKPFDPRLI GVVSS AVA K A 400
Cdd:PRK12862 325 NVLCFP Y IFRGALDVGATTIN E EMKIA AVRA IA E LAR EEQ S DVV AAAY G GE D L S FG PD YLIPKPFDPRLI LKIAP AVA Q A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 401 AM ET GVA A RPIED L DAY KRK L DGS V FK S A LIM R PVF ES A RSS P R R L VFAEGEDERVLRAAQ AIIE E TVER PILIGRP E VI 480
Cdd:PRK12862 405 AM DS GVA T RPIED M DAY REQ L NQF V YH S G LIM K PVF AA A KAA P K R V VFAEGEDERVLRAAQ VVVD E GLAK PILIGRP A VI 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 481 E R RIE K AGL N L QL G QNVDL VNPE N DPRYRDYW E TYH S LM C R R GV S P DI AR AIM R TN TT A IGA V MV H RGEAD SL ICGT F G E 560
Cdd:PRK12862 485 E A RIE R AGL R L RP G VDFEI VNPE D DPRYRDYW D TYH A LM G R K GV T P EM AR REV R RR TT L IGA M MV K RGEAD AM ICGT E G R 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 561 FGW HL NY V N QV L G - R D G F R PHG A L S MM IL EDGP LF I ADT Q VN LH PT P E QI AEI A I G AA RH VRRFGIEPKVAL C S Q S Q FG N 639
Cdd:PRK12862 565 YER HL EF V L QV I G k R P G V R VYA A M S LL IL PGRT LF L ADT H VN ED PT A E EL AEI T I L AA EE VRRFGIEPKVAL L S H S N FG S 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 640 QGEG S GKRL R A AL Q IL DAGNH D FVYE GEM NI D T ALD P ELR A R LL P CN R M EG A AN V LVF AHA DAA SGVR N I LK MK - G D GL E 718
Cdd:PRK12862 645 SDSP S ARKM R E AL E IL RERAP D LEVD GEM HG D A ALD E ELR D R IF P DS R L EG E AN L LVF PNL DAA NIAY N L LK TA a G N GL A 724
730 740 750
....*....|....*....|....*....|....*....
gi 1056502428 719 VGPIL M G MGNRA HI VS PS I T A R GLL N VG A I A GTPVAH Y G 757
Cdd:PRK12862 725 VGPIL L G AAKPV HI LT PS A T V R RIV N MT A L A VADANA Y R 763
Name
Accession
Description
Interval
E-value
PRK12862
PRK12862 malic enzyme; Reviewed
1-757
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1393.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M S DTPN LR Q AALDYH EH P R PGK L E VRA TKPLAN G RDLA R AYSPGVA EA C I EI KN DP DT AARYTSRGNLVAVV T NGTAVLG 80
Cdd:PRK12862 5 A S AKAE LR E AALDYH RF P T PGK I E IAP TKPLAN Q RDLA L AYSPGVA AP C L EI AA DP AN AARYTSRGNLVAVV S NGTAVLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LGNIG A LASKPVMEGKAVLFKKFA N ID C FDIELD QA DP E KL A EIV C A M EP S FG A INLEDIKAP D CF VV E KIC RERM N IPV 160
Cdd:PRK12862 85 LGNIG P LASKPVMEGKAVLFKKFA G ID V FDIELD ES DP D KL V EIV A A L EP T FG G INLEDIKAP E CF YI E REL RERM K IPV 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAI V V G AA AK N A L HVA GK KF ED I K I V ST G G GAA GI ACL NM L LK LGVKREN V W LC DI N G L VYEGRTE D M N P S KA 240
Cdd:PRK12862 165 FHDDQHGTAI I V A AA LL N G L KLV GK DI ED V K L V AS G A GAA AL ACL DL L VS LGVKREN I W VT DI K G V VYEGRTE L M D P W KA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 E YAQK S D L RTL DD VI D GAD L FLGLS GP GVL S PEMV A KMA K RP I IFALANPTPEILP DL ARAV A PDAIIATGRSD F PNQVN 320
Cdd:PRK12862 245 R YAQK T D A RTL AE VI E GAD V FLGLS AA GVL K PEMV K KMA P RP L IFALANPTPEILP EE ARAV R PDAIIATGRSD Y PNQVN 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVLCFP F IFRGALDVGATTIN D EMKIA CIDG IA A LAR ATT S AEA AAAY Q GE Q L T FG AE YLIPKPFDPRLI GVVSS AVA K A 400
Cdd:PRK12862 325 NVLCFP Y IFRGALDVGATTIN E EMKIA AVRA IA E LAR EEQ S DVV AAAY G GE D L S FG PD YLIPKPFDPRLI LKIAP AVA Q A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 401 AM ET GVA A RPIED L DAY KRK L DGS V FK S A LIM R PVF ES A RSS P R R L VFAEGEDERVLRAAQ AIIE E TVER PILIGRP E VI 480
Cdd:PRK12862 405 AM DS GVA T RPIED M DAY REQ L NQF V YH S G LIM K PVF AA A KAA P K R V VFAEGEDERVLRAAQ VVVD E GLAK PILIGRP A VI 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 481 E R RIE K AGL N L QL G QNVDL VNPE N DPRYRDYW E TYH S LM C R R GV S P DI AR AIM R TN TT A IGA V MV H RGEAD SL ICGT F G E 560
Cdd:PRK12862 485 E A RIE R AGL R L RP G VDFEI VNPE D DPRYRDYW D TYH A LM G R K GV T P EM AR REV R RR TT L IGA M MV K RGEAD AM ICGT E G R 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 561 FGW HL NY V N QV L G - R D G F R PHG A L S MM IL EDGP LF I ADT Q VN LH PT P E QI AEI A I G AA RH VRRFGIEPKVAL C S Q S Q FG N 639
Cdd:PRK12862 565 YER HL EF V L QV I G k R P G V R VYA A M S LL IL PGRT LF L ADT H VN ED PT A E EL AEI T I L AA EE VRRFGIEPKVAL L S H S N FG S 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 640 QGEG S GKRL R A AL Q IL DAGNH D FVYE GEM NI D T ALD P ELR A R LL P CN R M EG A AN V LVF AHA DAA SGVR N I LK MK - G D GL E 718
Cdd:PRK12862 645 SDSP S ARKM R E AL E IL RERAP D LEVD GEM HG D A ALD E ELR D R IF P DS R L EG E AN L LVF PNL DAA NIAY N L LK TA a G N GL A 724
730 740 750
....*....|....*....|....*....|....*....
gi 1056502428 719 VGPIL M G MGNRA HI VS PS I T A R GLL N VG A I A GTPVAH Y G 757
Cdd:PRK12862 725 VGPIL L G AAKPV HI LT PS A T V R RIV N MT A L A VADANA Y R 763
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-422
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 692.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M SDTPN L R Q A AL D YH EHPRP GK LE V RA T K PL ANGR DL AR AY S PGVAEAC I EI KN DP DT A AR YT SR GNLVAVVT N GTAVLG 80
Cdd:COG0281 3 M ERVET L E Q E AL E YH RIYDR GK IL V YP T V PL HTQE DL SL AY T PGVAEAC L EI AE DP RL A YG YT AK GNLVAVVT D GTAVLG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LG N IG A LA SK PVMEGKAVLFK K FA N ID C F D I E LD QA DP EKLA E I V C A M EP S FG A INLEDIKAP D CF VV E KIC RE RMN IPV 160
Cdd:COG0281 83 LG D IG P LA GM PVMEGKAVLFK A FA G ID A F P I C LD TN DP DEFV E A V K A L EP T FG G INLEDIKAP N CF EI E ERL RE ELD IPV 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAIVV G AA AK NAL HVA GKK F ED I KIV ST G G GAAGIA CLNM L LKL G VKR EN VWLC D IN GL V YEGRT e D M NP S K A 240
Cdd:COG0281 163 FHDDQHGTAIVV L AA LL NAL KLV GKK L ED Q KIV IN G A GAAGIA IARL L VAA G LSE EN IIMV D SK GL L YEGRT - D L NP Y K R 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 E Y A QKSDL R ---- TL DDV I D GAD L F L G L S G PG VLSP EMV AK MAKRPIIFALANPTPEI L P DL A R A VAPD AI I ATGRSD F P 316
Cdd:COG0281 242 E F A RDTNP R glkg TL AEA I K GAD V F I G V S A PG AFTE EMV KS MAKRPIIFALANPTPEI T P ED A K A WGDG AI V ATGRSD Y P 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 317 NQVNNVL C FP F IFRGALDV G AT T I N DEMK I A CIDGI A A L A rattsaeaaaayqg EQLTF G AE Y L IP K PFDPR LIGV V SS A 396
Cdd:COG0281 322 NQVNNVL I FP G IFRGALDV R AT R I T DEMK L A AARAL A D L V -------------- DEEEL G PD Y I IP S PFDPR VSPA V AA A 387
410 420
....*....|....*....|....*.
gi 1056502428 397 VAKAA M E T GVA A RPI E dl DA Y KRK L D 422
Cdd:COG0281 388 VAKAA I E S GVA R RPI D -- ED Y REA L E 411
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
165-402
4.57e-119
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 357.11
E-value: 4.57e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 165 Q H GTAIVV G A AAK NAL HVA GKK F ED IK IV ST G G GAAGI ACLNM L LKL GVKR E N V WL C D IN GL VYE GR TEDM NP S K AEY A Q 244
Cdd:smart00919 1 Q Q GTAIVV L A GLL NAL KIT GKK L ED QR IV VN G A GAAGI GIAKL L VAA GVKR K N I WL V D SK GL LTK GR EDNL NP Y K KPF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 245 K SDL R --- TL DDVID GAD LFL G L SGP - G VLSP EMV AK MA K RPIIFAL A NPTPEI L P DL A R A VAP - D AI I ATGRSD F PNQV 319
Cdd:smart00919 81 K TNE R etg TL EEAVK GAD VLI G V SGP g G AFTE EMV KS MA E RPIIFAL S NPTPEI E P TA A D A YRW t A AI V ATGRSD Y PNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 320 NNVL C FP F IF R GALDV G A TT I N DEMK I A CIDGI A AL arattsaeaaaa YQGEQLTF G AE Y L IP K PFD P R LIGV V SS AVAK 399
Cdd:smart00919 161 NNVL I FP G IF L GALDV R A RR I T DEMK L A AAEAL A DA ------------ VPVSEEEL G PG Y I IP S PFD R R VSAR V AV AVAK 228
...
gi 1056502428 400 AA M 402
Cdd:smart00919 229 AA I 231
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
165-401
4.17e-105
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 321.14
E-value: 4.17e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 165 QHGTAIV VG A AAK NAL HVA GKK F E DI KIV ST G G GAAGIA CLNM LL KL G V K R EN VWLC D IN G LV YEGR TE D M NP S K A E Y A Q 244
Cdd:cd05311 1 QHGTAIV TL A GLL NAL KLV GKK I E EV KIV IN G A GAAGIA IARL LL AA G A K P EN IVVV D SK G VI YEGR ED D L NP D K N E I A K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 245 KSDLR ---- TL DDVID GAD L F L G L S G PGV LSP EM VA KMAK R PI I FALANP T PEI L P DL A RAVAP D a I I ATGRSDFPNQVN 320
Cdd:cd05311 81 ETNPE ktgg TL KEALK GAD V F I G V S R PGV VKK EM IK KMAK D PI V FALANP V PEI W P EE A KEAGA D - I V ATGRSDFPNQVN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVL C FP F IFRGALDV G AT T I ND EMK I A CIDG IA A LA rattsaeaaaayqg E QLTF G A EY L IP K PFDPR LIGV V SS AVAKA 400
Cdd:cd05311 160 NVL G FP G IFRGALDV R AT K I TE EMK L A AAEA IA D LA -------------- E EEVL G E EY I IP T PFDPR VVPR V AT AVAKA 225
.
gi 1056502428 401 A 401
Cdd:cd05311 226 A 226
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
431-749
6.09e-82
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 263.79
E-value: 6.09e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 431 IMRPV FE S A RSSPR R L VF A EGEDERVL R AAQ AIIEETVER PILIG rp EV IE RRIEKA GL N L Q L GQ n VDL V N PE ND PR YRD 510
Cdd:pfam01515 1 FLERI FE R A KKAKK R I VF P EGEDERVL K AAQ KLLQQGIAD PILIG -- DE IE IKAKAL GL D L D L DG - IEI V D PE TS PR LEE 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 511 Y WET Y HS L MC R R G VS P D IAR A I M R t NTTAIG A VM V HR GEAD SLIC G TFGEFGWH L NYVN Q VL G - RD G FRPHGALSM M I L E 589
Cdd:pfam01515 78 Y ADF Y YE L RK R K G MT P E IAR E I V R - DPNYFA A ML V KL GEAD GMVS G AVNTTADT L RPAL Q II G t KP G VKTVSSVFI M L L P 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 590 DG P LF I AD TQ VN LH PT P E QI AEIA IGA A RHVR RFG - IEP K VAL C S Q S Q FG N - Q GE GSG K r L R A A LQ I LDAGNH D F V YE GE 667
Cdd:pfam01515 157 DG L LF F AD CA VN PN PT A E EL AEIA LMS A KTAK RFG i IEP R VAL L S Y S T FG S g K GE DVE K - V R E A TK I VRERAP D L V VD GE 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 668 MNI D T AL DP E LR A RLL P CNRME G A ANV L VF AHAD A ASGVRN I LKMK G DGLEV GPIL M G MGNRAHIV S PSITARGLL N VG A 747
Cdd:pfam01515 236 LQF D A AL VE E VA A QKA P DSPVA G K ANV F VF PDLE A GNIGYK I AQRL G GAEAI GPIL Q G LAKPVNDL S RGASVEDIV N TA A 315
..
gi 1056502428 748 I A 749
Cdd:pfam01515 316 I T 317
Name
Accession
Description
Interval
E-value
PRK12862
PRK12862 malic enzyme; Reviewed
1-757
0e+00
malic enzyme; Reviewed
Pssm-ID: 183799 [Multi-domain]
Cd Length: 763
Bit Score: 1393.46
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M S DTPN LR Q AALDYH EH P R PGK L E VRA TKPLAN G RDLA R AYSPGVA EA C I EI KN DP DT AARYTSRGNLVAVV T NGTAVLG 80
Cdd:PRK12862 5 A S AKAE LR E AALDYH RF P T PGK I E IAP TKPLAN Q RDLA L AYSPGVA AP C L EI AA DP AN AARYTSRGNLVAVV S NGTAVLG 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LGNIG A LASKPVMEGKAVLFKKFA N ID C FDIELD QA DP E KL A EIV C A M EP S FG A INLEDIKAP D CF VV E KIC RERM N IPV 160
Cdd:PRK12862 85 LGNIG P LASKPVMEGKAVLFKKFA G ID V FDIELD ES DP D KL V EIV A A L EP T FG G INLEDIKAP E CF YI E REL RERM K IPV 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAI V V G AA AK N A L HVA GK KF ED I K I V ST G G GAA GI ACL NM L LK LGVKREN V W LC DI N G L VYEGRTE D M N P S KA 240
Cdd:PRK12862 165 FHDDQHGTAI I V A AA LL N G L KLV GK DI ED V K L V AS G A GAA AL ACL DL L VS LGVKREN I W VT DI K G V VYEGRTE L M D P W KA 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 E YAQK S D L RTL DD VI D GAD L FLGLS GP GVL S PEMV A KMA K RP I IFALANPTPEILP DL ARAV A PDAIIATGRSD F PNQVN 320
Cdd:PRK12862 245 R YAQK T D A RTL AE VI E GAD V FLGLS AA GVL K PEMV K KMA P RP L IFALANPTPEILP EE ARAV R PDAIIATGRSD Y PNQVN 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVLCFP F IFRGALDVGATTIN D EMKIA CIDG IA A LAR ATT S AEA AAAY Q GE Q L T FG AE YLIPKPFDPRLI GVVSS AVA K A 400
Cdd:PRK12862 325 NVLCFP Y IFRGALDVGATTIN E EMKIA AVRA IA E LAR EEQ S DVV AAAY G GE D L S FG PD YLIPKPFDPRLI LKIAP AVA Q A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 401 AM ET GVA A RPIED L DAY KRK L DGS V FK S A LIM R PVF ES A RSS P R R L VFAEGEDERVLRAAQ AIIE E TVER PILIGRP E VI 480
Cdd:PRK12862 405 AM DS GVA T RPIED M DAY REQ L NQF V YH S G LIM K PVF AA A KAA P K R V VFAEGEDERVLRAAQ VVVD E GLAK PILIGRP A VI 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 481 E R RIE K AGL N L QL G QNVDL VNPE N DPRYRDYW E TYH S LM C R R GV S P DI AR AIM R TN TT A IGA V MV H RGEAD SL ICGT F G E 560
Cdd:PRK12862 485 E A RIE R AGL R L RP G VDFEI VNPE D DPRYRDYW D TYH A LM G R K GV T P EM AR REV R RR TT L IGA M MV K RGEAD AM ICGT E G R 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 561 FGW HL NY V N QV L G - R D G F R PHG A L S MM IL EDGP LF I ADT Q VN LH PT P E QI AEI A I G AA RH VRRFGIEPKVAL C S Q S Q FG N 639
Cdd:PRK12862 565 YER HL EF V L QV I G k R P G V R VYA A M S LL IL PGRT LF L ADT H VN ED PT A E EL AEI T I L AA EE VRRFGIEPKVAL L S H S N FG S 644
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 640 QGEG S GKRL R A AL Q IL DAGNH D FVYE GEM NI D T ALD P ELR A R LL P CN R M EG A AN V LVF AHA DAA SGVR N I LK MK - G D GL E 718
Cdd:PRK12862 645 SDSP S ARKM R E AL E IL RERAP D LEVD GEM HG D A ALD E ELR D R IF P DS R L EG E AN L LVF PNL DAA NIAY N L LK TA a G N GL A 724
730 740 750
....*....|....*....|....*....|....*....
gi 1056502428 719 VGPIL M G MGNRA HI VS PS I T A R GLL N VG A I A GTPVAH Y G 757
Cdd:PRK12862 725 VGPIL L G AAKPV HI LT PS A T V R RIV N MT A L A VADANA Y R 763
PRK07232
PRK07232 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
7-749
0e+00
bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed
Pssm-ID: 235976 [Multi-domain]
Cd Length: 752
Bit Score: 1257.69
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 7 L R QAALDYH EH PRPGK L EV RA TKPLA NG RDL AR AYSPGVA EA C I EI KN DP DT A AR YT S RGNLVAV VT NGTAVLGLGNIGA 86
Cdd:PRK07232 3 L K QAALDYH RF PRPGK I EV TP TKPLA TQ RDL SL AYSPGVA AP C L EI AK DP AD A YK YT A RGNLVAV IS NGTAVLGLGNIGA 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 87 LASKPVMEGK A VLFKKFA N ID C FDIE L D QA DP E K LA E I V C A M EP S FG A INLEDIKAP D CF VV E KIC RERM N IPVFHDDQH 166
Cdd:PRK07232 83 LASKPVMEGK G VLFKKFA G ID V FDIE V D EE DP D K FI E A V A A L EP T FG G INLEDIKAP E CF YI E EKL RERM D IPVFHDDQH 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 167 GTAI VVG AA AK NAL HVA GKK F ED I KIV ST G G GAA G IACLN M L LK LG V K R EN VWL CD IN G LV Y E GRTE D M NPS KA E YA QKS 246
Cdd:PRK07232 163 GTAI ISA AA LL NAL ELV GKK I ED V KIV VS G A GAA A IACLN L L VA LG A K K EN IIV CD SK G VI Y K GRTE G M DEW KA A YA VDT 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 247 D L RTL DDV I D GAD L FLGLS GP GVL S PEMV AK MA KR PIIFALANP T PEI L P DL A R AV A PDAIIATGRSD F PNQVNNVLCFP 326
Cdd:PRK07232 243 D A RTL AEA I E GAD V FLGLS AA GVL T PEMV KS MA DN PIIFALANP D PEI T P EE A K AV R PDAIIATGRSD Y PNQVNNVLCFP 322
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 327 F IFRGALDVGATTIN D EMK I A CIDG IA A LAR ATT S A E A AAAY Q G EQ L T FG A EY L IPKPFDPRLI GVVSS AVAKAAM ET GV 406
Cdd:PRK07232 323 Y IFRGALDVGATTIN E EMK L A AVRA IA E LAR EEV S D E V AAAY G G QK L S FG P EY I IPKPFDPRLI VKIAP AVAKAAM DS GV 402
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 407 A A RPI E D L DAY KR KL DGS V F K SA L I M R P V F ES A RSS P R R L VFAEGE D ERVLRAAQ AIIE E TVER PILIGRPEVIE R RI E K 486
Cdd:PRK07232 403 A T RPI A D M DAY RE KL EAF V Y K TG L V M K P I F AK A KKD P K R V VFAEGE E ERVLRAAQ EVVD E GLAK PILIGRPEVIE A RI K K 482
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 487 A GL N L QL G QNVDL VNPE N DPRY RD YW ET Y HS L MC R R GV S P DI AR AIM R TNT T A IGA V MV H RG E AD SL ICG TF G EFGW HL N 566
Cdd:PRK07232 483 L GL D L KA G VDFEI VNPE D DPRY EE YW QY Y YE L LQ R K GV T P ED AR RLV R RDR T V IGA M MV A RG D AD AM ICG LT G RYHE HL R 562
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 567 Y V N QV L G - R D G FRPHG A LSMMI L ED G P LFIADT Q VN LH PT P E QI AEIA IG AA RH VRRFGIEP K VAL C S Q S Q FG NQGEG S G 645
Cdd:PRK07232 563 P V R QV I G l R P G VHTAA A MNALL L KG G N LFIADT Y VN ED PT A E EL AEIA LM AA EE VRRFGIEP R VAL L S H S N FG SSDSP S A 642
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 646 KRL R A A LQI L DAGNH D FVYE GEM NI D T AL DP E L R AR L L P CN R ME G A ANVLV FAHAD AA SGVR N I LK MK G D G LEV GPIL M G 725
Cdd:PRK07232 643 RKM R E A VEL L RERAP D LEVD GEM HG D A AL NE E I R KD L Y P FS R LK G P ANVLV MPNLE AA NISY N L LK EL G G G VTI GPIL L G 722
730 740
....*....|....*....|....
gi 1056502428 726 M GNRA HI VS PS I T A R GLL N VG A I A 749
Cdd:PRK07232 723 M AKPV HI LT PS A T V R RIV N MT A L A 746
PRK12861
PRK12861 malic enzyme; Reviewed
1-748
0e+00
malic enzyme; Reviewed
Pssm-ID: 183798 [Multi-domain]
Cd Length: 764
Bit Score: 952.41
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M SD T PNL RQAALDYHE H P R PGK LE V R A T KPL ANG RDLA R AY S PGVA E AC I EI KN DP DT A A R Y TSRGNLV A V V TNGTAVLG 80
Cdd:PRK12861 1 M KQ T ETQ RQAALDYHE F P T PGK IS V V A S KPL VTQ RDLA L AY T PGVA S AC E EI AA DP LN A F R F TSRGNLV G V I TNGTAVLG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LGNIGALASKPVMEGKAVLFKKFA N ID C FDIE LDQA DP E KL AE I VCAM EP S FG A INLEDIKAP D CF V VE KIC RERM N IPV 160
Cdd:PRK12861 81 LGNIGALASKPVMEGKAVLFKKFA G ID V FDIE INET DP D KL VD I IAGL EP T FG G INLEDIKAP E CF T VE RKL RERM K IPV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAI V V G AA AK N A L H V A GK KFEDI K I V ST G G GAA GI ACL NM L LK LG VKR EN V W LC DI N G L VY E GRT ED M N P S K A 240
Cdd:PRK12861 161 FHDDQHGTAI T V S AA FI N G L K V V GK SIKEV K V V TS G A GAA AL ACL DL L VD LG LPV EN I W VT DI E G V VY R GRT TL M D P D K E 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 EY AQ KS D L RTL DD VI D GAD L FLGLS GP GVL SP EM VAK MA K RP I I F ALANPTPEI L P D LA R A VAP D AI IATGRSD F PNQVN 320
Cdd:PRK12861 241 RF AQ ET D A RTL AE VI G GAD V FLGLS AG GVL KA EM LKA MA A RP L I L ALANPTPEI F P E LA H A TRD D VV IATGRSD Y PNQVN 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVLCFP F IFRGALDVGATTI ND EM K IA CIDG IA A LA RATTSAEA AAAY QGEQLT FG AE YLIPKPFDPRLI GVVSS AVAKA 400
Cdd:PRK12861 321 NVLCFP Y IFRGALDVGATTI TR EM E IA AVHA IA G LA EEEQNDVV AAAY GAYDVS FG PQ YLIPKPFDPRLI VRIAP AVAKA 400
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 401 AME T GVA A RPI E DLDAY KRK L DGS V FK S ALI M R P V F ES AR SSP R ----- R L VF A EGEDERVLRA A Q A I IE E TVE RPIL I G 475
Cdd:PRK12861 401 AME G GVA T RPI A DLDAY VEQ L QQF V YH S GAF M K P L F AA AR QLV R dggka R I VF T EGEDERVLRA V Q V I VD E KLA RPIL V G 480
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 476 RPEV IER RIE KA GL N L Q LGQ N V DLV NPE N D P R YRD YW E TY HS L M CR R G V S PDI AR AI MR TNT T A IGA V MV HR G E AD SL IC 555
Cdd:PRK12861 481 RPEV LLA RIE RF GL R L R LGQ D V EVT NPE Y D E R FPQ YW T TY WE L R CR D G I S KEM AR VE MR RRL T L IGA M MV RL G D AD GM IC 560
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 556 GT F GE FGW HL NY V NQ V L GR - D G FRPHG A LSMMI L EDGPLFIA DT Q VN LH P TP EQIAE IA I G AAR HVRRFGIE PKVAL C S Q 634
Cdd:PRK12861 561 GT V GE YHN HL RF V DE V I GR k P G ASTYA A MNILL L DQRTVALV DT H VN DN P DA EQIAE FT I A AAR QMEWLNLT PKVAL L S R 640
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 635 S Q FG NQGEG SG KRL R A AL Q I LDAGNH D FVYE GEM NI D T ALD PE LRARLLP CNRME GAAN V LV FAHA DA ASGVR N I LK MK - 713
Cdd:PRK12861 641 S N FG SGSAA SG VKM R R AL E I VREQAP D LEAD GEM HG D C ALD EG LRARLLP MSPLK GAAN L LV CPNV DA GNIAY N L LK TE a 720
730 740 750
....*....|....*....|....*....|....*
gi 1056502428 714 G DGLE VGP I L M G MGNRAH I VSP S I T A R GLL N VG A I 748
Cdd:PRK12861 721 G SNVA VGP F L L G VNAPVN I LTS S A T V R RIV N MA A L 755
SfcA
COG0281 Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: ...
1-422
0e+00
Malic enzyme [Energy production and conversion]; Malic enzyme is part of the Pathway/BioSystem: Urea cycle
Pssm-ID: 440050 [Multi-domain]
Cd Length: 414
Bit Score: 692.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 1 M SDTPN L R Q A AL D YH EHPRP GK LE V RA T K PL ANGR DL AR AY S PGVAEAC I EI KN DP DT A AR YT SR GNLVAVVT N GTAVLG 80
Cdd:COG0281 3 M ERVET L E Q E AL E YH RIYDR GK IL V YP T V PL HTQE DL SL AY T PGVAEAC L EI AE DP RL A YG YT AK GNLVAVVT D GTAVLG 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LG N IG A LA SK PVMEGKAVLFK K FA N ID C F D I E LD QA DP EKLA E I V C A M EP S FG A INLEDIKAP D CF VV E KIC RE RMN IPV 160
Cdd:COG0281 83 LG D IG P LA GM PVMEGKAVLFK A FA G ID A F P I C LD TN DP DEFV E A V K A L EP T FG G INLEDIKAP N CF EI E ERL RE ELD IPV 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 161 FHDDQHGTAIVV G AA AK NAL HVA GKK F ED I KIV ST G G GAAGIA CLNM L LKL G VKR EN VWLC D IN GL V YEGRT e D M NP S K A 240
Cdd:COG0281 163 FHDDQHGTAIVV L AA LL NAL KLV GKK L ED Q KIV IN G A GAAGIA IARL L VAA G LSE EN IIMV D SK GL L YEGRT - D L NP Y K R 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 241 E Y A QKSDL R ---- TL DDV I D GAD L F L G L S G PG VLSP EMV AK MAKRPIIFALANPTPEI L P DL A R A VAPD AI I ATGRSD F P 316
Cdd:COG0281 242 E F A RDTNP R glkg TL AEA I K GAD V F I G V S A PG AFTE EMV KS MAKRPIIFALANPTPEI T P ED A K A WGDG AI V ATGRSD Y P 321
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 317 NQVNNVL C FP F IFRGALDV G AT T I N DEMK I A CIDGI A A L A rattsaeaaaayqg EQLTF G AE Y L IP K PFDPR LIGV V SS A 396
Cdd:COG0281 322 NQVNNVL I FP G IFRGALDV R AT R I T DEMK L A AARAL A D L V -------------- DEEEL G PD Y I IP S PFDPR VSPA V AA A 387
410 420
....*....|....*....|....*.
gi 1056502428 397 VAKAA M E T GVA A RPI E dl DA Y KRK L D 422
Cdd:COG0281 388 VAKAA I E S GVA R RPI D -- ED Y REA L E 411
Malic_M
smart00919 Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the ...
165-402
4.57e-119
Malic enzyme, NAD binding domain; Malic enzymes (malate oxidoreductases) catalyse the oxidative decarboxylation of malate to form pyruvate.
Pssm-ID: 214912
Cd Length: 231
Bit Score: 357.11
E-value: 4.57e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 165 Q H GTAIVV G A AAK NAL HVA GKK F ED IK IV ST G G GAAGI ACLNM L LKL GVKR E N V WL C D IN GL VYE GR TEDM NP S K AEY A Q 244
Cdd:smart00919 1 Q Q GTAIVV L A GLL NAL KIT GKK L ED QR IV VN G A GAAGI GIAKL L VAA GVKR K N I WL V D SK GL LTK GR EDNL NP Y K KPF A R 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 245 K SDL R --- TL DDVID GAD LFL G L SGP - G VLSP EMV AK MA K RPIIFAL A NPTPEI L P DL A R A VAP - D AI I ATGRSD F PNQV 319
Cdd:smart00919 81 K TNE R etg TL EEAVK GAD VLI G V SGP g G AFTE EMV KS MA E RPIIFAL S NPTPEI E P TA A D A YRW t A AI V ATGRSD Y PNQV 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 320 NNVL C FP F IF R GALDV G A TT I N DEMK I A CIDGI A AL arattsaeaaaa YQGEQLTF G AE Y L IP K PFD P R LIGV V SS AVAK 399
Cdd:smart00919 161 NNVL I FP G IF L GALDV R A RR I T DEMK L A AAEAL A DA ------------ VPVSEEEL G PG Y I IP S PFD R R VSAR V AV AVAK 228
...
gi 1056502428 400 AA M 402
Cdd:smart00919 229 AA I 231
Pta
COG0280 Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production ...
432-749
3.77e-116
Phosphotransacetylase (includes Pta, EutD and phosphobutyryltransferase) [Energy production and conversion];
Pssm-ID: 440049 [Multi-domain]
Cd Length: 320
Bit Score: 353.22
E-value: 3.77e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 432 M RP VF E S A RSS P R R L VFAEGEDERVLRAAQ AIIE E TVER PIL I GRPE V IE R R I E KA GL N L Q lgq NVDLVN PE ND PRY RD Y 511
Cdd:COG0280 3 F RP LI E R A KAA P K R I VFAEGEDERVLRAAQ EALD E GLAE PIL V GRPE K IE A R A E EL GL D L S --- GFEIID PE DS PRY EE Y 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 512 W E T Y HS L MC R R GV S P DI AR AIM R t NTTAIG A V MV HR GEAD S L IC G TF G EFGWH L NY V N Q VL G - R D G FRPHGALSM M I L E D 590
Cdd:COG0280 80 A E A Y YE L RK R K GV T P EE AR ELV R - DAAYFA A M MV RL GEAD G L VK G AV G TTADL L RP V L Q II G l R P G VKRVSHVFL M E L P D 158
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 591 GP LFI A DT Q VN LH PT P EQ I A E IAI G AA RHV R R FGIEPKVAL C S Q S Q FG NQGEG S GKRL R A A LQILDAGNH D FVYE GE MNI 670
Cdd:COG0280 159 RL LFI T DT A VN ID PT A EQ L A D IAI N AA DTA R A FGIEPKVAL L S A S E FG SPKGP S TDKV R E A TKMARGQIP D LEVD GE LQF 238
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1056502428 671 D T AL D PE LRA R LL P CNRME G A ANVLVF AHAD A ASGVRNI L KMKGDGLEV GPIL M G MGNRA H IV S PSITA R GLL N VG A I A 749
Cdd:COG0280 239 D A AL S PE AAK R KG P DSPVA G D ANVLVF PDLE A GNILYKL L QRLAGAEAI GPIL L G LAKPV H LL S RGDSV R DIV N SI A L A 317
NAD_bind_2_malic_enz
cd05311 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the ...
165-401
4.17e-105
NAD(P) binding domain of malic enzyme (ME), subgroup 2; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists primarily of archaeal and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133453 [Multi-domain]
Cd Length: 226
Bit Score: 321.14
E-value: 4.17e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 165 QHGTAIV VG A AAK NAL HVA GKK F E DI KIV ST G G GAAGIA CLNM LL KL G V K R EN VWLC D IN G LV YEGR TE D M NP S K A E Y A Q 244
Cdd:cd05311 1 QHGTAIV TL A GLL NAL KLV GKK I E EV KIV IN G A GAAGIA IARL LL AA G A K P EN IVVV D SK G VI YEGR ED D L NP D K N E I A K 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 245 KSDLR ---- TL DDVID GAD L F L G L S G PGV LSP EM VA KMAK R PI I FALANP T PEI L P DL A RAVAP D a I I ATGRSDFPNQVN 320
Cdd:cd05311 81 ETNPE ktgg TL KEALK GAD V F I G V S R PGV VKK EM IK KMAK D PI V FALANP V PEI W P EE A KEAGA D - I V ATGRSDFPNQVN 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 321 NVL C FP F IFRGALDV G AT T I ND EMK I A CIDG IA A LA rattsaeaaaayqg E QLTF G A EY L IP K PFDPR LIGV V SS AVAKA 400
Cdd:cd05311 160 NVL G FP G IFRGALDV R AT K I TE EMK L A AAEA IA D LA -------------- E EEVL G E EY I IP T PFDPR VVPR V AT AVAKA 225
.
gi 1056502428 401 A 401
Cdd:cd05311 226 A 226
PTA_PTB
pfam01515 Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase ...
431-749
6.09e-82
Phosphate acetyl/butaryl transferase; This family contains both phosphate acetyltransferase and phosphate butaryltransferase. These enzymes catalyze the transfer of an acetyl or butaryl group to orthophosphate.
Pssm-ID: 396207 [Multi-domain]
Cd Length: 318
Bit Score: 263.79
E-value: 6.09e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 431 IMRPV FE S A RSSPR R L VF A EGEDERVL R AAQ AIIEETVER PILIG rp EV IE RRIEKA GL N L Q L GQ n VDL V N PE ND PR YRD 510
Cdd:pfam01515 1 FLERI FE R A KKAKK R I VF P EGEDERVL K AAQ KLLQQGIAD PILIG -- DE IE IKAKAL GL D L D L DG - IEI V D PE TS PR LEE 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 511 Y WET Y HS L MC R R G VS P D IAR A I M R t NTTAIG A VM V HR GEAD SLIC G TFGEFGWH L NYVN Q VL G - RD G FRPHGALSM M I L E 589
Cdd:pfam01515 78 Y ADF Y YE L RK R K G MT P E IAR E I V R - DPNYFA A ML V KL GEAD GMVS G AVNTTADT L RPAL Q II G t KP G VKTVSSVFI M L L P 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 590 DG P LF I AD TQ VN LH PT P E QI AEIA IGA A RHVR RFG - IEP K VAL C S Q S Q FG N - Q GE GSG K r L R A A LQ I LDAGNH D F V YE GE 667
Cdd:pfam01515 157 DG L LF F AD CA VN PN PT A E EL AEIA LMS A KTAK RFG i IEP R VAL L S Y S T FG S g K GE DVE K - V R E A TK I VRERAP D L V VD GE 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 668 MNI D T AL DP E LR A RLL P CNRME G A ANV L VF AHAD A ASGVRN I LKMK G DGLEV GPIL M G MGNRAHIV S PSITARGLL N VG A 747
Cdd:pfam01515 236 LQF D A AL VE E VA A QKA P DSPVA G K ANV F VF PDLE A GNIGYK I AQRL G GAEAI GPIL Q G LAKPVNDL S RGASVEDIV N TA A 315
..
gi 1056502428 748 I A 749
Cdd:pfam01515 316 I T 317
eutD
PRK09653 phosphotransacetylase;
437-726
1.19e-39
phosphotransacetylase;
Pssm-ID: 236609 [Multi-domain]
Cd Length: 324
Bit Score: 149.22
E-value: 1.19e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 437 E S A RSSPRRL V FA EGEDERVL R AA QAIIE E TVER PIL I G R PE V I ERRIEKA GL N L qlg QN V DLVN PE ND P RYRDYW E TYH 516
Cdd:PRK09653 9 E K A KGKKKKI V LP EGEDERVL K AA KRLQK E GLVE PIL L G N PE E I RAKAKEL GL D L --- DG V EIID PE TY P LLEEFA E AFV 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 517 S L mc R R G - VSPDI A RAIMRTN t TAI G AVM V HR G E AD SLIC G tfgefgwh LNYVNQ vlgr D GF RP hg AL ------------ 583
Cdd:PRK09653 86 E L -- R K G k GTEED A AELLKDP - NYF G TML V KL G K AD GMVS G -------- AIHSTA ---- D TL RP -- AL qiiktkpgvktv 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 584 - S MM I LE - DGPLF I - AD TQ VN LH PT P EQ I AEIAI GA A RHVRR FGI E PKVA LC S qsq F GNQ G EGS G --- KRLRA A LQ I LDA 657
Cdd:PRK09653 149 s S VF I MV k GDERY I f AD CA VN PN PT A EQ L AEIAI NS A ETAKA FGI D PKVA ML S --- F STK G SAK G pev DKVQE A TE I AKE 225
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1056502428 658 GNH D FVYE GE MNI D T A LD PE LR A RLL P CNRME G A ANV L VF AHAD A A sgvr NI - L K MK --- G DGLE VGPIL M G M 726
Cdd:PRK09653 226 LAP D LKID GE LQF D A A FV PE VA A KKA P GSPVA G K ANV F VF PSLE A G ---- NI g Y K IA qrl G GFEA VGPIL Q G L 294
PTZ00317
PTZ00317 NADP-dependent malic enzyme; Provisional
41-347
3.55e-37
NADP-dependent malic enzyme; Provisional
Pssm-ID: 240357 [Multi-domain]
Cd Length: 559
Bit Score: 147.08
E-value: 3.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 41 Y S P G V A EAC IEIK N DP d TAA R -- Y T S --- R G NL ------------- V A V V T N G TAV LGLG NI GA l ASKPVME GK AV L FKK 102
Cdd:PTZ00317 106 Y T P T V G EAC QNYS N LF - QRD R gl Y L S rah K G KI reilknwpydnvd V I V I T D G SRI LGLG DL GA - NGMGISI GK LS L YVA 183
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 103 FAN I D --- CFDIE LD -------- QA DP EK L A ---------------- E IVC A MEPSF -- GAINL ED IKAPD CF VVEKICR 153
Cdd:PTZ00317 184 GGG I N psr VLPVV LD vgtnnekl LN DP LY L G lrekrldddeyyelld E FME A VSSRW pn AVVQF ED FSNNH CF DLLERYQ 263
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 154 ER mn IPV F H DD QH GT AI V VG A AAK NAL HVA G KKF E DIK IV ST G G G A A G I ACL N MLLK L ---- GV K RE ---- NVW L C D IN G 225
Cdd:PTZ00317 264 NK -- YRC F N DD IQ GT GA V IA A GFL NAL KLS G VPP E EQR IV FF G A G S A A I GVA N NIAD L aaey GV T RE ealk SFY L V D SK G 341
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 226 LV YEG R TEDMNPS K AEY A QK ------ S D L R TL D DV IDGA -- DLF LGLSG - P GV LSP E M V AK MA --- K RPIIF A L A NPT P - 292
Cdd:PTZ00317 342 LV TTT R GDKLAKH K VPF A RT disaed S S L K TL E DV VRFV kp TAL LGLSG v G GV FTE E V V KT MA snv E RPIIF P L S NPT S k 421
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1056502428 293 - E ILPDL A - RAVAPD AI I A T G r S D F ----------- P N Q V NN VLC FP FIFR G ALDVGATT I N DEM K IA 347
Cdd:PTZ00317 422 a E CTAED A y KWTNGR AI V A S G - S P F ppvtlngktiq P S Q G NN LYV FP GVGL G CAIAQPSY I P DEM L IA 488
malic
pfam00390 Malic enzyme, N-terminal domain;
20-150
5.38e-36
Malic enzyme, N-terminal domain;
Pssm-ID: 395314 [Multi-domain]
Cd Length: 182
Bit Score: 133.93
E-value: 5.38e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 20 P GK L EV RAT K P L AN -- GR DL ARA Y S P G V A EAC IE I KNDPDTA - AR YTS R GNL ---------------- V A VVT N G TAV LG 80
Cdd:pfam00390 1 Q GK N EV LFY K L L ST hi EE DL PIV Y T P T V G EAC QA I SEIYRRP r GL YTS I GNL gkikdilknwpeedvr V I VVT D G ERI LG 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 81 LG NI G A l A SK P V MEGK AV L FKK FA N ID --- CFD I E LD --------------------------- QADPEKLA E I V C A ME P 130
Cdd:pfam00390 81 LG DL G V - A GM P I MEGK LA L YTA FA G ID psr VLP I V LD vgtnnekllndplylglrhkrvrgeey DEFVDEFV E A V K A LF P 159
170 180
....*....|....*....|
gi 1056502428 131 S FG A I NL ED IK AP DC F VVEK 150
Cdd:pfam00390 160 P FG G I QF ED FG AP NA F EILE 179
PLN03129
PLN03129 NADP-dependent malic enzyme; Provisional
41-421
3.33e-35
NADP-dependent malic enzyme; Provisional
Pssm-ID: 215594 [Multi-domain]
Cd Length: 581
Bit Score: 141.59
E-value: 3.33e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 41 Y S P G V A EAC IE ------------------------ I KN D P DTAAR ytsrgnl V A VVT N G TAV LGLG NI G ALA skpv M --- 93
Cdd:PLN03129 129 Y T P T V G EAC QK ygslfrrprglyislkdkgrvlsm L KN W P ERDVQ ------- V I VVT D G ERI LGLG DL G VQG ---- M gip 197
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 94 E GK AV L FKKFAN I D --- CFDIEL D -------- QA DP ---------------- E KLA E IVC A MEPSF G A --- INL ED IKAP 143
Cdd:PLN03129 198 V GK LD L YTAAGG I R psa VLPVCI D vgtnnekl LN DP fyiglrqprltgeeyd E LVD E FME A VKQRW G P kvl VQF ED FANK 277
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 144 DC F VVEK ic R E R MNIPV F H DD QH GTA I V VG A AAKN AL HVA G KKFE D IK I VST G G G A AG IACLNMLLKLGVK --------- 214
Cdd:PLN03129 278 NA F RLLQ -- R Y R TTHLC F N DD IQ GTA A V AL A GLLA AL RAT G GDLA D QR I LFA G A G E AG TGIAELIALAMSR qtgiseeea 355
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 215 R ENV WL C D IN GLV YEG R TEDMN P S K AEY A QK - SDLRT L DDVIDGA -- DLFL GLSG - P G VLSP E MVAK MA K --- RPIIFAL 287
Cdd:PLN03129 356 R KRI WL V D SK GLV TKS R KDSLQ P F K KPF A HD h EPGAS L LEAVKAI kp TVLI GLSG v G G TFTK E VLEA MA S lne RPIIFAL 435
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 288 A NPT -- P E ILPDL A - RAVAPD AI I A T G r S D F ----------- P N Q V NN VLC FP F I FR GAL DV GA TTIN D E M KI A CIDGI A 353
Cdd:PLN03129 436 S NPT sk A E CTAEE A y TWTGGR AI F A S G - S P F dpveyngktfh P G Q A NN AYI FP G I GL GAL LS GA IRVT D D M LL A AAEAL A 514
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1056502428 354 A LARA ttsaeaaaayqg E Q L TF GA E Y li P k PF DP - R L I GV - V SS AVA KA A M E T G V A A R P -- I EDL DA Y KRKL 421
Cdd:PLN03129 515 A QVTE ------------ E E L AK GA I Y -- P - PF SR i R D I SA h V AA AVA AK A Y E E G L A T R L pr P EDL VE Y AESC 571
PRK05632
PRK05632 phosphate acetyltransferase; Reviewed
413-697
1.15e-34
phosphate acetyltransferase; Reviewed
Pssm-ID: 235537 [Multi-domain]
Cd Length: 684
Bit Score: 141.06
E-value: 1.15e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 413 D L D AYKRK L DGSVFK S ALIMR P V F ----- E S AR SSPR R L V FA EG EDE R V L R AA QAII E ETVERPI L I G R PE V I E R RIEKA 487
Cdd:PRK05632 342 D T D ELLER L TATSER S RRLSP P A F ryqlt E R AR AAKK R I V LP EG DEP R T L K AA AICL E RGIADCV L L G N PE E I R R VAAAQ 421
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 488 G ln LQ L GQNVDLVN P en DPRYRD Y WETYHS L MCRR G VSPDI AR AIM r TNTTAI G AV M VHR GE A D S L IC G ---- T fgefgw 563
Cdd:PRK05632 422 G -- VD L PAGIEIID P -- SEVRER Y VAPLVE L RKHK G MTEEV AR EQL - EDNVYF G TM M LAL GE V D G L VS G avht T ------ 490
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 564 hlny V N QV lgrdgf RP hg AL SM --------------- M I L E D GP L FIA D TQ VN LH PT P EQ I AEIAI GA A RHVRR FGIEP K 628
Cdd:PRK05632 491 ---- A N TI ------ RP -- AL QL iktapgsslvssvff M L L P D QV L VYG D CA VN PD PT A EQ L AEIAI QS A DSAAA FGIEP R 558
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 629 VA LC S Q S Q f G NQ G E G SG - KRL R A A LQILDAGNH D FVYE G EMNI D T A L DP ELRARLL P CNRME G A A N V LV F 697
Cdd:PRK05632 559 VA ML S Y S T - G TS G S G AD v EKV R E A TRLARERRP D LLID G PLQY D A A V DP SVARSKA P NSPVA G R A T V FI F 627
PRK13529
PRK13529 oxaloacetate-decarboxylating malate dehydrogenase;
41-416
5.43e-33
oxaloacetate-decarboxylating malate dehydrogenase;
Pssm-ID: 237414 [Multi-domain]
Cd Length: 563
Bit Score: 134.49
E-value: 5.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 41 Y S P G V A EAC ---------------- IEIKNDPDTAARYTSRGNL - VA VVT N G TAV LG L G NI G ALA skpv M E --- GK AV L F 100
Cdd:PRK13529 104 Y T P T V G EAC erfshiyrrprglfis YDDRDRIEDILQNAPNRDI k LI VVT D G ERI LG I G DQ G IGG ---- M G ipi GK LS L Y 179
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 101 KKFAN ID --- CFDIE LD -------- QA DP ---------------- E KLA E I V C A MEPS F - G A - INL ED IKAPDCFVVEK i 151
Cdd:PRK13529 180 TACGG ID par TLPVV LD vgtnneql LN DP lylgwrhprirgeeyd E FVD E F V Q A VKRR F p N A l LQF ED FAQKNARRILE - 258
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 152 c R E R MN I PV F H DD QH GT AI V VG A AAKN AL HVA G KKFE D IK IV ST G G G A AG IACLNMLLKLG V K -------- R ENVWLC D I 223
Cdd:PRK13529 259 - R Y R DE I CT F N DD IQ GT GA V TL A GLLA AL KIT G EPLS D QR IV FL G A G S AG CGIADQIVAAM V R eglseeea R KRFFMV D R 337
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 224 N GL VYEGRT e D MNPSKAE YA Q K ---------- S D LRT L DD V IDGA -- DLFL G L SG - PG VLSP E M V AK MA K --- RPIIF A L 287
Cdd:PRK13529 338 Q GL LTDDMP - D LLDFQKP YA R K reeladwdte G D VIS L LE V VRNV kp TVLI G V SG q PG AFTE E I V KE MA A hce RPIIF P L 416
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 288 A NPT peilp DL A R A VAP D -------- A II ATG r S D F PN ----------- Q V NN VLC FP FIFR G ALDV GA TTIN D E M KI A C 348
Cdd:PRK13529 417 S NPT ----- SR A E A TPE D liawtdgr A LV ATG - S P F AP veyngktypig Q C NN AYI FP GLGL G VIAS GA RRVT D G M LM A A 490
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1056502428 349 IDGI A ALARA ttsaeaaaayqg EQLTF GA EY lipkpfd P RL -- I GV VS ---- S AVAKAA M E T G V A ARP - I EDL DA 416
Cdd:PRK13529 491 AHAL A DCVPL ------------ AKPGE GA LL ------- P PV ed I RE VS raia I AVAKAA I E E G L A RET s D EDL EQ 546
NAD_bind_1_malic_enz
cd05312 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the ...
167-417
1.45e-32
NAD(P) binding domain of malic enzyme (ME), subgroup 1; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms, and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. This subfamily consists of eukaryotic and bacterial ME. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133454
Cd Length: 279
Bit Score: 127.28
E-value: 1.45e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 167 GTA I V VG A AAKN AL HVA GK KFE D IK I VST G G G A AGI ACLNMLLKLG V K -------- R ENV WL C D IN GL VYEG R t E D MN P S 238
Cdd:cd05312 3 GTA A V AL A GLLA AL RIT GK PLS D QR I LFL G A G S AGI GIADLIVSAM V R eglseeea R KKI WL V D SK GL LTKD R - K D LT P F 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 239 K AEY A Q K --- SDLRT L DD V ID -- GADLFL GLSG - P G VLSP E M V AK MAK --- RPIIFAL A NPT peilp DL A RAV A P DA --- 306
Cdd:cd05312 82 K KPF A R K dee KEGKS L LE V VK av KPTVLI GLSG v G G AFTE E V V RA MAK sne RPIIFAL S NPT ----- SK A ECT A E DA ykw 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 307 ----- II A T G r S D F ----------- P N Q V NN VLC FP F I FR GA LDV GA TT I N DEM KI A CIDGI A A L ARATTS A eaaaay Q G 370
Cdd:cd05312 157 tdgra LF A S G - S P F ppveyngktyv P G Q G NN AYI FP G I GL GA ILS GA RH I T DEM FL A AAEAL A S L VTDEEL A ------ R G 229
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1056502428 371 E qltfgaey L I P KPFDP R L I GV - VSS AVAK A A M E T G V A A R -- P I EDL DA Y 417
Cdd:cd05312 230 R -------- L Y P PLSNI R E I SA q IAV AVAK Y A Y E E G L A T R yp P P EDL EE Y 271
Malic_M
pfam03949 Malic enzyme, NAD binding domain;
167-355
9.91e-31
Malic enzyme, NAD binding domain;
Pssm-ID: 427608 [Multi-domain]
Cd Length: 257
Bit Score: 121.53
E-value: 9.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 167 GTA I V VG A AAKN AL HVA GK KFEDIK IV ST G G G A AGI ACLNMLLKLG V K -------- R ENV W LC D IN GL VYEG R t ED MNPS 238
Cdd:pfam03949 3 GTA A V AL A GLLA AL KIT GK PLSEQR IV FF G A G S AGI GIADQIRDAM V R eglseeea R KRI W MV D RQ GL LTDD R - ED LTDF 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 239 KAEY A Q K ------- S D LR TL DD V IDGA -- DLFL G L SG - PG VLSP E M V AK MA K --- RPIIF A L A NPT P eilpd L A R A VAP D 305
Cdd:pfam03949 82 QKPF A R K raelkgw G D GI TL LE V VRKV kp TVLI G A SG v PG AFTE E I V RA MA A hte RPIIF P L S NPT S ----- K A E A TPE D 156
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1056502428 306 -------- A II ATG r S D F ----------- PN Q V NN VLC FP FIFR GA LDVG A TT I N DEM KI A CIDGI A AL 355
Cdd:pfam03949 157 aykwtdgr A LF ATG - S P F ppveyngktyh IG Q G NN AYI FP GLGL GA IVSR A RR I T DEM FL A AAEAL A SY 224
NAD_bind_malic_enz
cd00762 NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid ...
165-353
1.97e-30
NAD(P) binding domain of malic enzyme; Malic enzyme (ME), a member of the amino acid dehydrogenase (DH)-like domain family, catalyzes the oxidative decarboxylation of L-malate to pyruvate in the presence of cations (typically Mg++ or Mn++) with the concomitant reduction of cofactor NAD+ or NADP+. ME has been found in all organisms and plays important roles in diverse metabolic pathways such as photosynthesis and lipogenesis. This enzyme generally forms homotetramers. The conversion of malate to pyruvate by ME typically involves oxidation of malate to produce oxaloacetate, followed by decarboxylation of oxaloacetate to produce pyruvate and CO2. Amino acid DH-like NAD(P)-binding domains are members of the Rossmann fold superfamily and include glutamate, leucine, and phenylalanine DHs, methylene tetrahydrofolate DH, methylene-tetrahydromethanopterin DH, methylene-tetrahydropholate DH/cyclohydrolase, Shikimate DH-like proteins, malate oxidoreductases, and glutamyl tRNA reductase. Amino acid DHs catalyze the deamination of amino acids to keto acids with NAD(P)+ as a cofactor. The NAD(P)-binding Rossmann fold superfamily includes a wide variety of protein families including NAD(P)- binding domains of alcohol DHs, tyrosine-dependent oxidoreductases, glyceraldehyde-3-phosphate DH, lactate/malate DHs, formate/glycerate DHs, siroheme synthases, 6-phosphogluconate DH, amino acid DHs, repressor rex, NAD-binding potassium channel domain, CoA-binding, and ornithine cyclodeaminase-like domains. These domains have an alpha-beta-alpha configuration. NAD binding involves numerous hydrogen and van der Waals contacts.
Pssm-ID: 133442
Cd Length: 254
Bit Score: 120.40
E-value: 1.97e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 165 QH GTA I V VG A AAKN AL H V AG KK FEDI K IVST G G GAA GIACL N MLLK L G VK R -------- ENV W LC D IN GL VYEG R T E d MN 236
Cdd:cd00762 1 IQ GTA S V AV A GLLA AL K V TK KK ISEH K VLFN G A GAA ALGIA N LIV* L * VK E giskeeac KRI W *V D RK GL LVKN R K E - TC 79
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 237 P SKAEY A Q ---- KSDLRT L D D VID -- GA D LFL G L S GP G - VLS PE MVAKM A --- K RP I IFAL A NPT P -- E ILPDL A R - A VA 303
Cdd:cd00762 80 P NEYHL A R fanp ERESGD L E D AVE aa KP D FLI G V S RV G g AFT PE VIRA* A ein E RP V IFAL S NPT S ka E CTAEE A Y t A TE 159
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056502428 304 PD AI I A T G RSDF P N ---------- Q V NN VLC FP FIFR G ALDVGATT I N D EMKIACIDG IA 353
Cdd:cd00762 160 GR AI F A S G SPFH P V elnggtykpg Q G NN LYI FP GVAL G VILCRIRH I T D DVFLSAAEA IA 219
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
