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Conserved domains on  [gi|1056907434|ref|WP_068321507|]
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HEPN domain-containing protein [Pyrococcus kukulkanii]

Protein Classification

HEPN domain-containing protein( domain architecture ID 10004863)

HEPN (higher eukarytoes and prokaryotes nucleotide)-binding domain-containing protein may be involved in nucleotide binding; similar to Homo sapiens sacsin, a 520-kDa protein mutated in the early-onset neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS); HEPN (higher eukarytoes and prokaryotes nucleotide)-binding domain-containing protein may be involved in nucleotide binding; similar to Homo sapiens sacsin, a 520-kDa protein mutated in the early-onset neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS); HEPN (higher eukarytoes and prokaryotes nucleotide)-binding domain-containing protein may be involved in nucleotide binding; similar to Thermotoga maritima HEPN domain protein (TM0613); HEPN (higher eukarytoes and prokaryotes nucleotide)-binding domain-containing protein may be involved in nucleotide binding; similar to Thermus thermophilus protein Tt1696; HEPN (higher eukarytoes and prokaryotes nucleotide)-binding domain-containing protein may be involved in nucleotide binding; similar to Thermotoga maritima HEPN domain protein (TM0613)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEPN COG1895
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
6-125 2.90e-45

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


:

Pssm-ID: 441499  Cd Length: 120  Bit Score: 143.52  E-value: 2.90e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434   6 EVIRHIEIAEEELSSANLLLQNGKLRDAISRAYYSMFHAAKALLLMKGINPKKHSGVVMMFGLHFVDEGFIERTYAKYLA 85
Cdd:COG1895     1 LVATLLEKAEEKLAAAKLLLENGLYEDAINRAYYAMFHAAKALLLSKGLSPKTHSGVISAFGEHFVKTGKIDLELGRFLS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1056907434  86 SAFSLRSRADYDIYYEPSLEEAEAVVENAERFLQRIKRAL 125
Cdd:COG1895    81 RAFQLRQNADYGGEAEPTEEEAKEYIEQAEEFLEEIKAYL 120
 
Name Accession Description Interval E-value
HEPN COG1895
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
6-125 2.90e-45

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


Pssm-ID: 441499  Cd Length: 120  Bit Score: 143.52  E-value: 2.90e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434   6 EVIRHIEIAEEELSSANLLLQNGKLRDAISRAYYSMFHAAKALLLMKGINPKKHSGVVMMFGLHFVDEGFIERTYAKYLA 85
Cdd:COG1895     1 LVATLLEKAEEKLAAAKLLLENGLYEDAINRAYYAMFHAAKALLLSKGLSPKTHSGVISAFGEHFVKTGKIDLELGRFLS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1056907434  86 SAFSLRSRADYDIYYEPSLEEAEAVVENAERFLQRIKRAL 125
Cdd:COG1895    81 RAFQLRQNADYGGEAEPTEEEAKEYIEQAEEFLEEIKAYL 120
HEPN pfam05168
HEPN domain;
9-123 8.36e-24

HEPN domain;


Pssm-ID: 398711  Cd Length: 117  Bit Score: 88.83  E-value: 8.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434   9 RHIEIAEEELSSANLLLQNGKLRDAISRAYYSMFHAAKALLLMKGINPKKHSGVVMMFGLHFvDEGFIERTYAKYLASAF 88
Cdd:pfam05168   3 DWLRRAEEDLEAAELLLEEGDYDWACFHAQQAAEKALKALLLKLGGDPPKTHDLRELLGELK-KGLGLPEELREILDELE 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1056907434  89 SLRSRADYDIYYEPSLEEAEAVVENAERFLQRIKR 123
Cdd:pfam05168  82 KAYIESRYPDADEGTEEDAEEALKDAEEILELVEE 116
 
Name Accession Description Interval E-value
HEPN COG1895
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
6-125 2.90e-45

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


Pssm-ID: 441499  Cd Length: 120  Bit Score: 143.52  E-value: 2.90e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434   6 EVIRHIEIAEEELSSANLLLQNGKLRDAISRAYYSMFHAAKALLLMKGINPKKHSGVVMMFGLHFVDEGFIERTYAKYLA 85
Cdd:COG1895     1 LVATLLEKAEEKLAAAKLLLENGLYEDAINRAYYAMFHAAKALLLSKGLSPKTHSGVISAFGEHFVKTGKIDLELGRFLS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1056907434  86 SAFSLRSRADYDIYYEPSLEEAEAVVENAERFLQRIKRAL 125
Cdd:COG1895    81 RAFQLRQNADYGGEAEPTEEEAKEYIEQAEEFLEEIKAYL 120
HEPN pfam05168
HEPN domain;
9-123 8.36e-24

HEPN domain;


Pssm-ID: 398711  Cd Length: 117  Bit Score: 88.83  E-value: 8.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434   9 RHIEIAEEELSSANLLLQNGKLRDAISRAYYSMFHAAKALLLMKGINPKKHSGVVMMFGLHFvDEGFIERTYAKYLASAF 88
Cdd:pfam05168   3 DWLRRAEEDLEAAELLLEEGDYDWACFHAQQAAEKALKALLLKLGGDPPKTHDLRELLGELK-KGLGLPEELREILDELE 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1056907434  89 SLRSRADYDIYYEPSLEEAEAVVENAERFLQRIKR 123
Cdd:pfam05168  82 KAYIESRYPDADEGTEEDAEEALKDAEEILELVEE 116
HEPN COG2250
HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];
11-127 3.03e-05

HEPN domain protein, predicted toxin of MNT-HEPN system [Defense mechanisms];


Pssm-ID: 441851  Cd Length: 121  Bit Score: 40.71  E-value: 3.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1056907434  11 IEIAEEELSSANLLLQNGKLRDAisrayysMFHA-------AKALLLMKGINPKK-HSGVVMMFGLHFVDEGFIE-RTYA 81
Cdd:COG2250     1 LRRAERDLEAAELLLEEGRYDLA-------CFHAqqaaekaLKALLLALGGEPPKtHDLRELLELLEKLLPEPEElRDLL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1056907434  82 KYLaSAFSLRSR---ADYDIYYEPSLEEAEAVVENAERFLQRIKRALEE 127
Cdd:COG2250    74 RLL-DKAYIPARypdALPEGPEEYTREEAEEALELAEEVLEFVEKLLKE 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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