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Conserved domains on  [gi|1061036080|ref|WP_069147945|]
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BtrH N-terminal domain-containing protein [Elizabethkingia anophelis]

Protein Classification

BtrH N-terminal domain-containing protein( domain architecture ID 11233448)

BtrH N-terminal domain-containing protein similar to the N-terminal domain of Bacillus circulans butirosin biosynthesis protein H (BtrH), an aminoglycoside acyltransferase that attaches the (S)-4-amino-2-hydroxybutyrate side chain from the acyl carrier protein BtrI to the aminoglycoside ribostamycin in the biosynthetic pathway of butirosin; also contains a DUF4872 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4872 pfam16169
Domain of unknown function (DUF4872); Members of this family are often found in the gene ...
 153-323 2.03e-58

Domain of unknown function (DUF4872); Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases.


:

Pssm-ID: 435184  Cd Length: 173  Bit Score: 185.89  E-value: 2.03e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 153 ESLEQARAAKG-PMASKNLYYTIKSTGTNFDLKKAVSTAIRNNAIEYLNPPITNIAYKGILKTSTEIIKWFN--TSKDIE 229
Cdd:pfam16169   1 DALARARFAKGfPAPKGHMYYPLAIPDKLPDLAKAIRKAIKKNARAMLNPPVPNAGVRGIRKLAKDIRKWPEkfGADDLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 230 KEFALSAMLMERAGTGGALFRNLYRDFLKESYELLKLDVLKTGYEVFAEIAEHWTSVSQLFEKVSQTKDIIYiHKASDIL 309
Cdd:pfam16169  81 LYLRQLVRMQEEIGTGGGGFRFLYADFLQEAAELLGDPALAELSELMTEAADAWRDFALLAARAGKGREADL-AEAADAL 159

                         170
                  ....*....|....
gi 1061036080 310 KAIADKEKKTMELL 323
Cdd:pfam16169 160 EELAELEEEAFTAL 173
BtrH_N pfam14399
Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier ...
 13-141 1.20e-52

Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier protein:aminoglycoside acyltransferase BtrH. Alternatively it can be referred to as butirosin biosynthesis protein H. BtrH transfers the unique (S)-4-amino-2-hydroxybutyrate (AHBA) side chain, which protects the antibiotic butirosin from several common resistance mechanisms. Butirosin, an aminoglycoside antibiotic produced by Bacillus circulans, exhibits improved antibiotic properties over its parent molecule and retains bactericidal activity toward many aminoglycoside-resistant strains. Butirosin is unique in carrying the AHBA side-chain. BtrH transfers the AHBA from the acyl carrier protein BtrI to the parent aminoglycoside ribostamycin as a gamma-glutamylated dipeptide.


:

Pssm-ID: 433933  Cd Length: 134  Bit Score: 169.72  E-value: 1.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080  13 HCETTATGTLLQRIGIELSEPMLFGLGEGLGFIYWNM-KIMDFPFIGGRIKPDLLTKNITKNLNLELLVKETSSKQKAWE 91
Cdd:pfam14399   1 HCESGALADLLAHAGLPLSEPMAFGLGGGLGFVYLPFkKLNPLPLIGGRTKPGDLFKRLAKRLGIKVKRRTTSDPDEAWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1061036080  92 EVKEHLDSGQAVGLKMDCYYLDYFS--NPVHFAGHYAAIYGYDD--YSAFLVDT 141
Cdd:pfam14399  81 ALDAELDAGRPVGLQVDVYYLPYFPkeYRFHFNAHNLVVYGYDDegGVYLVSDP 134
 
Name Accession Description Interval E-value
DUF4872 pfam16169
Domain of unknown function (DUF4872); Members of this family are often found in the gene ...
 153-323 2.03e-58

Domain of unknown function (DUF4872); Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases.


Pssm-ID: 435184  Cd Length: 173  Bit Score: 185.89  E-value: 2.03e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 153 ESLEQARAAKG-PMASKNLYYTIKSTGTNFDLKKAVSTAIRNNAIEYLNPPITNIAYKGILKTSTEIIKWFN--TSKDIE 229
Cdd:pfam16169   1 DALARARFAKGfPAPKGHMYYPLAIPDKLPDLAKAIRKAIKKNARAMLNPPVPNAGVRGIRKLAKDIRKWPEkfGADDLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 230 KEFALSAMLMERAGTGGALFRNLYRDFLKESYELLKLDVLKTGYEVFAEIAEHWTSVSQLFEKVSQTKDIIYiHKASDIL 309
Cdd:pfam16169  81 LYLRQLVRMQEEIGTGGGGFRFLYADFLQEAAELLGDPALAELSELMTEAADAWRDFALLAARAGKGREADL-AEAADAL 159

                         170
                  ....*....|....
gi 1061036080 310 KAIADKEKKTMELL 323
Cdd:pfam16169 160 EELAELEEEAFTAL 173
BtrH_N pfam14399
Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier ...
 13-141 1.20e-52

Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier protein:aminoglycoside acyltransferase BtrH. Alternatively it can be referred to as butirosin biosynthesis protein H. BtrH transfers the unique (S)-4-amino-2-hydroxybutyrate (AHBA) side chain, which protects the antibiotic butirosin from several common resistance mechanisms. Butirosin, an aminoglycoside antibiotic produced by Bacillus circulans, exhibits improved antibiotic properties over its parent molecule and retains bactericidal activity toward many aminoglycoside-resistant strains. Butirosin is unique in carrying the AHBA side-chain. BtrH transfers the AHBA from the acyl carrier protein BtrI to the parent aminoglycoside ribostamycin as a gamma-glutamylated dipeptide.


Pssm-ID: 433933  Cd Length: 134  Bit Score: 169.72  E-value: 1.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080  13 HCETTATGTLLQRIGIELSEPMLFGLGEGLGFIYWNM-KIMDFPFIGGRIKPDLLTKNITKNLNLELLVKETSSKQKAWE 91
Cdd:pfam14399   1 HCESGALADLLAHAGLPLSEPMAFGLGGGLGFVYLPFkKLNPLPLIGGRTKPGDLFKRLAKRLGIKVKRRTTSDPDEAWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1061036080  92 EVKEHLDSGQAVGLKMDCYYLDYFS--NPVHFAGHYAAIYGYDD--YSAFLVDT 141
Cdd:pfam14399  81 ALDAELDAGRPVGLQVDVYYLPYFPkeYRFHFNAHNLVVYGYDDegGVYLVSDP 134
 
Name Accession Description Interval E-value
DUF4872 pfam16169
Domain of unknown function (DUF4872); Members of this family are often found in the gene ...
 153-323 2.03e-58

Domain of unknown function (DUF4872); Members of this family are often found in the gene neighbourhood, or fused to, non-ribosomal peptide synthetases.


Pssm-ID: 435184  Cd Length: 173  Bit Score: 185.89  E-value: 2.03e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 153 ESLEQARAAKG-PMASKNLYYTIKSTGTNFDLKKAVSTAIRNNAIEYLNPPITNIAYKGILKTSTEIIKWFN--TSKDIE 229
Cdd:pfam16169   1 DALARARFAKGfPAPKGHMYYPLAIPDKLPDLAKAIRKAIKKNARAMLNPPVPNAGVRGIRKLAKDIRKWPEkfGADDLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080 230 KEFALSAMLMERAGTGGALFRNLYRDFLKESYELLKLDVLKTGYEVFAEIAEHWTSVSQLFEKVSQTKDIIYiHKASDIL 309
Cdd:pfam16169  81 LYLRQLVRMQEEIGTGGGGFRFLYADFLQEAAELLGDPALAELSELMTEAADAWRDFALLAARAGKGREADL-AEAADAL 159

                         170
                  ....*....|....
gi 1061036080 310 KAIADKEKKTMELL 323
Cdd:pfam16169 160 EELAELEEEAFTAL 173
BtrH_N pfam14399
Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier ...
 13-141 1.20e-52

Butirosin biosynthesis protein H, N-terminal; BtrH_N is the N-terminus of the acyl carrier protein:aminoglycoside acyltransferase BtrH. Alternatively it can be referred to as butirosin biosynthesis protein H. BtrH transfers the unique (S)-4-amino-2-hydroxybutyrate (AHBA) side chain, which protects the antibiotic butirosin from several common resistance mechanisms. Butirosin, an aminoglycoside antibiotic produced by Bacillus circulans, exhibits improved antibiotic properties over its parent molecule and retains bactericidal activity toward many aminoglycoside-resistant strains. Butirosin is unique in carrying the AHBA side-chain. BtrH transfers the AHBA from the acyl carrier protein BtrI to the parent aminoglycoside ribostamycin as a gamma-glutamylated dipeptide.


Pssm-ID: 433933  Cd Length: 134  Bit Score: 169.72  E-value: 1.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061036080  13 HCETTATGTLLQRIGIELSEPMLFGLGEGLGFIYWNM-KIMDFPFIGGRIKPDLLTKNITKNLNLELLVKETSSKQKAWE 91
Cdd:pfam14399   1 HCESGALADLLAHAGLPLSEPMAFGLGGGLGFVYLPFkKLNPLPLIGGRTKPGDLFKRLAKRLGIKVKRRTTSDPDEAWA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1061036080  92 EVKEHLDSGQAVGLKMDCYYLDYFS--NPVHFAGHYAAIYGYDD--YSAFLVDT 141
Cdd:pfam14399  81 ALDAELDAGRPVGLQVDVYYLPYFPkeYRFHFNAHNLVVYGYDDegGVYLVSDP 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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