Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063218728  15 RACVEECPVDCI-YEGKRMLYIHPDECVDCGACEPVCPVEAIFYE 58
Cdd:cd10549    84 GLCVKVCPVDAItLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128

hypothetical protein; Provisional

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063218728  17 CVEECPVDCIY--EGKRMLYIHPDECVDCGACEPVCPVEAIF 56
Cdd:PRK13795  589 CVGACPTGAIRieEGKRKISVDEEKCIHCGKCTEVCPVVKYK 630

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1063218728  17 CVEECPVDCI--YEGKrmlyihP---DECVDCGACEPVCPVEAIFY 57
Cdd:NF038196  193 CAKVCPVNNIemEDGK------PvwgHNCTHCLACIHRCPKEAIEY 232

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063218728   3 YIIAQPCVDvlDRACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAIFYEDDVPD 63
Cdd:COG4231    18 VIDEDKCTG--CGACVKVCPADAIEEGDGKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063218728   4 IIAQPCVDVLDRACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAIFYEDDVPD 63
Cdd:COG4624    86 IIRDKEKCKNCYPCVRACPVKAIKVDDGKAEIDEEKCISCGQCVAVCPFGAITEKSDIEK 145

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063218728  15 RACVEECPVDCIY-EGKRMLYIHPDECVDCGACEPVCPVEAIFYEDDVPDEW 65
Cdd:COG1149    17 GLCVEVCPEGAIKlDDGGAPVVDPDLCTGCGACVGVCPTGAITLEEREAGKI 68

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063218728  15 RACVEECPVDCI-YEGKRMLYIHPDECVDCGACEPVCPVEAIFYE 58
Cdd:cd10549    84 GLCVKVCPVDAItLEDELEIVIDKEKCIGCGICAEVCPVNAIKLV 128

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063218728   3 YIIAQPCVDVLDRACVEECPVDCIYEGKRML-YIHPDECVDCGACEPVCPVEAIFYEDDV 61
Cdd:cd04410    44 AFLPVSCMHCEDPPCVKACPTGAIYKDEDGIvLIDEDKCIGCGSCVEACPYGAIVFDPEP 103

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1063218728  14 DRACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAIFYEDDVP 62
Cdd:COG1142    57 DAPCAEVCPVGAITRDDGAVVVDEEKCIGCGLCVLACPFGAITMVGEKS 105

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063218728   9 CVDVLDRACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAIFYEDD 60
Cdd:COG4624    62 CRCCVAISCIQVRGIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDG 113

hypothetical protein; Provisional

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063218728  17 CVEECPVDCIY--EGKRMLYIHPDECVDCGACEPVCPVEAIF 56
Cdd:PRK13795  589 CVGACPTGAIRieEGKRKISVDEEKCIHCGKCTEVCPVVKYK 630

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063218728  15 RACVEECPVDCI----YEGKRMLYIHPDECVDCGACEPVCPVE 53
Cdd:cd16373   103 GVCVEACPTEAIaivlEDDVLRPVVDEDKCVGCGLCEYVCPVE 145

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063218728   9 CVDVLDRACVEECPVDCIYEGKR-MLYIHPDECVDCGACEPVCPVEAIFYEDDVP 62
Cdd:cd10562    70 CMHCTDAACVKVCPTGALYKTENgAVVVDEDKCIGCGYCVAACPFDVPRYDETTN 124

Polyferredoxin NapH [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1063218728  15 RACVEECPVDC-IYEGKrmlyIHPDECVDCGACEPVCPVEAIFYE 58
Cdd:COG0348   216 GLCVKVCPMGIdIRKGE----INQSECINCGRCIDACPKDAIRFS 256

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1063218728  14 DRACVEECPVDCIY--EGKRMLYIHPDECVDCGACEPVCPVEAIFY 57
Cdd:cd10550    54 DAPCVEACPVGAISrdEETGAVVVDEDKCIGCGMCVEACPFGAIRV 99

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063218728  16 ACVEECPVDCIYEG-KRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:TIGR01944 120 KCIQACPVDAIVGAaKAMHTVIADECTGCDLCVEPCPTDCI 160

Fe-S cluster domain-containing protein;

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063218728  15 RACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:PRK07118  219 GKCVKACPAGAITMENNLAVIDQEKCTSCGKCVEKCPTKAI 259

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063218728   9 CVDVLDRACVEECPVDCIY--EGKRMLYiHPDECVDCGACEPVCPVEAIFYEDD 60
Cdd:cd16370    53 CRACEDPPCAEACPTGALEprKGGGVVL-DKEKCIGCGNCVKACIVGAIFWDEE 105

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1063218728  17 CVEECPVDCI--YEGKrmlyihP---DECVDCGACEPVCPVEAIFY 57
Cdd:NF038196  193 CAKVCPVNNIemEDGK------PvwgHNCTHCLACIHRCPKEAIEY 232

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1063218728  15 RACVEECPVDCI-YEGKRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:COG1148   502 GRCVEVCPYGAIsIDEKGVAEVNPALCKGCGTCAAACPSGAI 543

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063218728  17 CVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAIFYED 59
Cdd:cd03110    72 CERVCKFGAILEFFQKLIVDESLCEGCGACVIICPRGAIYLKD 114

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063218728  16 ACVEECPVDCIYegKR---MLYIHPDECVDCGACEPVCPVEAIFYEDD 60
Cdd:cd16371    61 ACVKVCPTGAIT--KRedgIVVVDQDKCIGCGYCVWACPYGAPQYNPE 106

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063218728   5 IAQPCVDVLDRACVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:cd16367    53 VPTACRHCVDPVCMIGCPTGAIHRDDGGEVVISDACCGCGNCASACPYGAI 103

Fe-S cluster domain-containing protein;

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1063218728  17 CVEECPVDCIYEGKRMLYIHPDECVDCGACEPVCP 51
Cdd:PRK07118  147 CVAACPFDAIHIENGLPVVDEDKCTGCGACVKACP 181

Ferredoxin-like protein FixX [Energy production and conversion];

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063218728   9 CVDV-LDRACVEECPVDCiYE--GKRMLYIHPDECVDCGACEPVCPVEAI 55
Cdd:COG2440    23 CIARcLAKPCTRYCPAGV-YEivGDGRLQINYENCLECGTCRIKCPTQNI 71

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1063218728  29 GKRMLYIHPDECVDCGACEPVCPVEAIFYEDD 60
Cdd:COG1149     2 KRKIPVIDEEKCIGCGLCVEVCPEGAIKLDDG 33

NADH-quinone oxidoreductase subunit G;

                          10        20
                  ....*....|....*....|.
gi 1063218728  39 ECVDCGACEPVCPVEAIFYED 59
Cdd:PRK08493  205 DCSFCGECIAVCPVGALSSSD 225