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Conserved domains on  [gi|1071011050|ref|WP_069785303|]
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MULTISPECIES: bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF [Aeromonas]

Protein Classification

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase( domain architecture ID 11484157)

bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase catalyzes the fourth and fifth steps of tryptophan biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 46-500 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


:

Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 834.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDALTPSDRDFEGDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIYGHYA 125
Cdd:PRK09427    4 PTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHYA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 126 TAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVL 205
Cdd:PRK09427   84 SAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 206 TEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHHAKGFLVGSSLMA 285
Cdd:PRK09427  164 TEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLMA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 286 EPDLEAAVRKLVLGQNKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPLSYVGVFRNAQPATIAK 365
Cdd:PRK09427  244 EDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIVD 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 366 TVDALGLAAVQLHGDEDAAYVEALRALLPAGCQIWKAVGVTSgePLPALDYP-ADRLLLDTkvgsQSGGTGQAFDWTLLA 444
Cdd:PRK09427  324 IAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGD--TLPARDLQhVDRYLLDN----GQGGTGQTFDWSLLP 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1071011050 445 GLDKSKLMLAGGLNPDNALEAARVGCVGLDFNSGVESAPGRKDAHKLAAAFGALRQ 500
Cdd:PRK09427  398 GQSLDNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRA 453
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 46-500 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 834.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDALTPSDRDFEGDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIYGHYA 125
Cdd:PRK09427    4 PTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHYA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 126 TAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVL 205
Cdd:PRK09427   84 SAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 206 TEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHHAKGFLVGSSLMA 285
Cdd:PRK09427  164 TEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLMA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 286 EPDLEAAVRKLVLGQNKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPLSYVGVFRNAQPATIAK 365
Cdd:PRK09427  244 EDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIVD 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 366 TVDALGLAAVQLHGDEDAAYVEALRALLPAGCQIWKAVGVTSgePLPALDYP-ADRLLLDTkvgsQSGGTGQAFDWTLLA 444
Cdd:PRK09427  324 IAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGD--TLPARDLQhVDRYLLDN----GQGGTGQTFDWSLLP 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1071011050 445 GLDKSKLMLAGGLNPDNALEAARVGCVGLDFNSGVESAPGRKDAHKLAAAFGALRQ 500
Cdd:PRK09427  398 GQSLDNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRA 453
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 46-297 2.22e-129

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 376.29  E-value: 2.22e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDAL--TPSDRDFEGDLR-QGSTRFILECKKASPSKGLIRNDFSPEAIADIYG 122
Cdd:COG0134     1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRaAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 123 HY-ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELG 201
Cdd:COG0134    81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 202 LGVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALR-HHAKGFLVG 280
Cdd:COG0134   161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAaAGADAFLVG 240

                         250
                  ....*....|....*..
gi 1071011050 281 SSLMAEPDLEAAVRKLV 297
Cdd:COG0134   241 EALMRAPDPGAALRELL 257
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
49-295 1.33e-119

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 351.21  E-value: 1.33e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  49 LGKIVAAKQEWVAARKESQPLASFQ-DALTPSDRDFEGDLRQGS--TRFILECKKASPSKGLIRNDFSPEAIADIYGHY- 124
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQaAARAPPTRSFYDALRESRgrPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 125 ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGV 204
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 205 LTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHH-AKGFLVGSSL 283
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHgANAFLVGESL 240

                         250
                  ....*....|..
gi 1071011050 284 MAEPDLEAAVRK 295
Cdd:pfam00218 241 MRQEDVRAAIRE 252
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 90-296 4.50e-102

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 304.77  E-value: 4.50e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  90 GSTRFILECKKASPSKGLIRNDFSPEAIADIYGHY-ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVY 168
Cdd:cd00331     9 GGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFIIDPYQIY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 169 LARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAAR 248
Cdd:cd00331    89 EARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTTERLAPL 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1071011050 249 IPGDRVVISESGINHRAQVAALRHH-AKGFLVGSSLMAEPDLEAAVRKL 296
Cdd:cd00331   169 IPKDVILVSESGISTPEDVKRLAEAgADAVLIGESLMRAPDPGAALREL 217
 
Name Accession Description Interval E-value
PRK09427 PRK09427
bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase ...
 46-500 0e+00

bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF;


Pssm-ID: 236509 [Multi-domain]  Cd Length: 454  Bit Score: 834.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDALTPSDRDFEGDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIYGHYA 125
Cdd:PRK09427    4 PTVLAKIVADKAIWVAARKQQQPLASFQNEIQPSDRSFYDALKGPKTAFILECKKASPSKGLIRDDFDPAEIARVYKHYA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 126 TAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVL 205
Cdd:PRK09427   84 SAISVLTDEKYFQGSFDFLPIVRAIVTQPILCKDFIIDPYQIYLARYYGADAILLMLSVLDDEQYRQLAAVAHSLNMGVL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 206 TEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHHAKGFLVGSSLMA 285
Cdd:PRK09427  164 TEVSNEEELERAIALGAKVIGINNRNLRDLSIDLNRTRELAPLIPADVIVISESGIYTHAQVRELSPFANGFLIGSSLMA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 286 EPDLEAAVRKLVLGQNKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPLSYVGVFRNAQPATIAK 365
Cdd:PRK09427  244 EDDLELAVRKLILGENKVCGLTRPQDAKAAYDAGAVYGGLIFVEKSPRYVSLEQAQEIIAAAPLRYVGVFRNADIEDIVD 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 366 TVDALGLAAVQLHGDEDAAYVEALRALLPAGCQIWKAVGVTSgePLPALDYP-ADRLLLDTkvgsQSGGTGQAFDWTLLA 444
Cdd:PRK09427  324 IAKQLSLAAVQLHGDEDQAYIDALREALPKTCQIWKAISVGD--TLPARDLQhVDRYLLDN----GQGGTGQTFDWSLLP 397

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1071011050 445 GLDKSKLMLAGGLNPDNALEAARVGCVGLDFNSGVESAPGRKDAHKLAAAFGALRQ 500
Cdd:PRK09427  398 GQSLDNVLLAGGLNPDNCQQAAQLGCAGLDFNSGVESAPGIKDAQKLASVFQTLRA 453
TrpC COG0134
Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol ...
 46-297 2.22e-129

Indole-3-glycerol phosphate synthase [Amino acid transport and metabolism]; Indole-3-glycerol phosphate synthase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439904  Cd Length: 257  Bit Score: 376.29  E-value: 2.22e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDAL--TPSDRDFEGDLR-QGSTRFILECKKASPSKGLIRNDFSPEAIADIYG 122
Cdd:COG0134     1 PTILDKIVAHKREEVAARKARVPLAELEARAaaAPPPRDFAAALRaAGGPAVIAEIKKASPSKGLIREDFDPAEIARAYE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 123 HY-ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELG 201
Cdd:COG0134    81 AGgAAAISVLTDEKFFQGSLEDLRAVRAAVDLPVLRKDFIIDPYQIYEARAAGADAILLIAAALDDEQLKELLALAHSLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 202 LGVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALR-HHAKGFLVG 280
Cdd:COG0134   161 MDVLVEVHDEEELERALALGARLIGINNRNLKTFEVDLETTERLAPLIPADVLVVSESGIRTPEDVARLAaAGADAFLVG 240

                         250
                  ....*....|....*..
gi 1071011050 281 SSLMAEPDLEAAVRKLV 297
Cdd:COG0134   241 EALMRAPDPGAALRELL 257
IGPS pfam00218
Indole-3-glycerol phosphate synthase;
49-295 1.33e-119

Indole-3-glycerol phosphate synthase;


Pssm-ID: 395163  Cd Length: 252  Bit Score: 351.21  E-value: 1.33e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  49 LGKIVAAKQEWVAARKESQPLASFQ-DALTPSDRDFEGDLRQGS--TRFILECKKASPSKGLIRNDFSPEAIADIYGHY- 124
Cdd:pfam00218   1 LEKIVADKRAEVAARKARPPLADLQaAARAPPTRSFYDALRESRgrPALIAEVKKASPSKGLIREDFDPAEIARVYEAAg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 125 ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGV 204
Cdd:pfam00218  81 ASAISVLTDPKYFQGSIEYLRAVRQAVSLPVLRKDFIIDEYQIDEARLAGADAILLIVAVLDDELLEELYAYARSLGMEV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 205 LTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHH-AKGFLVGSSL 283
Cdd:pfam00218 161 LVEVHNEEELERALALGAKIIGVNNRNLKTFEVDLNTTRRLAPLIPADVLLVAESGIYTPADVRELKEHgANAFLVGESL 240

                         250
                  ....*....|..
gi 1071011050 284 MAEPDLEAAVRK 295
Cdd:pfam00218 241 MRQEDVRAAIRE 252
trpC PRK00278
indole-3-glycerol phosphate synthase TrpC;
46-299 1.21e-113

indole-3-glycerol phosphate synthase TrpC;


Pssm-ID: 234710  Cd Length: 260  Bit Score: 335.97  E-value: 1.21e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  46 QTILGKIVAAKQEWVAARKESQPLASFQDALT--PSDRDFEGDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIY-G 122
Cdd:PRK00278    2 MDILDKIVAYKREEVAARKAQVPLAELKARAAaaPPPRDFAAALRAGKPAVIAEVKKASPSKGVIREDFDPVEIAKAYeA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 123 HYATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGL 202
Cdd:PRK00278   82 GGAACLSVLTDERFFQGSLEYLRAARAAVSLPVLRKDFIIDPYQIYEARAAGADAILLIVAALDDEQLKELLDYAHSLGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 203 GVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALR-HHAKGFLVGS 281
Cdd:PRK00278  162 DVLVEVHDEEELERALKLGAPLIGINNRNLKTFEVDLETTERLAPLIPSDRLVVSESGIFTPEDLKRLAkAGADAVLVGE 241

                         250
                  ....*....|....*...
gi 1071011050 282 SLMAEPDLEAAVRKLVLG 299
Cdd:PRK00278  242 SLMRADDPGAALRELLGA 259
IGPS cd00331
Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, ...
 90-296 4.50e-102

Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the release of carbon dioxide and water. IGPS is active as a separate monomer in most organisms, but is also found fused to other enzymes as part of a bifunctional or multifunctional enzyme involved in tryptophan biosynthesis.


Pssm-ID: 238203  Cd Length: 217  Bit Score: 304.77  E-value: 4.50e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  90 GSTRFILECKKASPSKGLIRNDFSPEAIADIYGHY-ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVY 168
Cdd:cd00331     9 GGLGVIAEVKRASPSKGLIREDFDPVEIAKAYEKAgAAAISVLTEPKYFQGSLEDLRAVREAVSLPVLRKDFIIDPYQIY 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 169 LARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAAR 248
Cdd:cd00331    89 EARAAGADAVLLIVAALDDEQLKELYELARELGMEVLVEVHDEEELERALALGAKIIGINNRDLKTFEVDLNTTERLAPL 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1071011050 249 IPGDRVVISESGINHRAQVAALRHH-AKGFLVGSSLMAEPDLEAAVRKL 296
Cdd:cd00331   169 IPKDVILVSESGISTPEDVKRLAEAgADAVLIGESLMRAPDPGAALREL 217
TrpF COG0135
Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; ...
 301-500 8.44e-78

Phosphoribosylanthranilate isomerase [Amino acid transport and metabolism]; Phosphoribosylanthranilate isomerase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 439905  Cd Length: 208  Bit Score: 242.35  E-value: 8.44e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 301 NKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAP--LSYVGVFRNAQPATIAKTVDALGLAAVQLH 378
Cdd:COG0135     4 VKICGLTRPEDARAAVEAGADALGFVFYPKSPRYVSPEQAAELAAALPpfVKKVGVFVNADPEEILEIVEAVGLDAVQLH 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 379 GDEDAAYVEALRALLpaGCQIWKAVGVTSGEPLPALDY---PADRLLLDTKVGSQSGGTGQAFDWTLLAGLD-KSKLMLA 454
Cdd:COG0135    84 GDESPEYCAALRERL--GLPVIKAIRVGDGADLEEAAAyapVADALLLDAKVPGLYGGTGKTFDWSLLAGLAlPKPVILA 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1071011050 455 GGLNPDNALEAAR-VGCVGLDFNSGVESAPGRKDAHKLAAAFGALRQ 500
Cdd:COG0135   162 GGLTPENVAEAIRlVRPYGVDVSSGVESAPGVKDPDKIRAFVEAVRA 208
PRAI cd00405
Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan ...
 301-495 1.88e-72

Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric, monofunctional and thermolabile, but in some thermophile organisms PRAI is dimeric for reasons of stability and in others it is fused to other components of the tryptophan biosynthesis pathway to form multifunctional enzymes.


Pssm-ID: 238237  Cd Length: 203  Bit Score: 228.23  E-value: 1.88e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 301 NKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAP--LSYVGVFRNAQPATIAKTVDALGLAAVQLH 378
Cdd:cd00405     1 VKICGITTLEDALAAAEAGADAIGFIFAPKSPRYVSPEQAREIVAALPpfVKRVGVFVNEDLEEILEIAEELGLDVVQLH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 379 GDEDAAYVEALRALLpaGCQIWKAVGVTSGEPLP---ALDYPADRLLLDTKVGSQSGGTGQAFDWTLLAGLDKSK-LMLA 454
Cdd:cd00405    81 GDESPEYCAQLRARL--GLPVIKAIRVKDEEDLEkaaAYAGEVDAILLDSKSGGGGGGTGKTFDWSLLRGLASRKpVILA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1071011050 455 GGLNPDNALEA-ARVGCVGLDFNSGVESAPGRKDAHKLAAAF 495
Cdd:cd00405   159 GGLTPDNVAEAiRLVRPYGVDVSSGVETSPGIKDPEKIRAFI 200
PLN02460 PLN02460
indole-3-glycerol-phosphate synthase
 9-296 8.62e-62

indole-3-glycerol-phosphate synthase


Pssm-ID: 215254  Cd Length: 338  Bit Score: 205.40  E-value: 8.62e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050   9 PRGTHPERPTGNSQLRKDNEmsdviaphaflnmASISQTILGKIVAAKQEWVAARKESQPLASFQDAL--TPSDRDFEGD 86
Cdd:PLN02460   42 PPTGPPLHYVGPFQFRLQNE-------------GNTPRNILEEIVWYKDVEVAQMKERKPLYLLKKALqnAPPARDFVGA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  87 LRQGSTR-----FILECKKASPSKGLIRNDFSPEAIADIY-GHYATAISVLTDEKFFQGDFAFLPRVRGR-VQQPVLCKD 159
Cdd:PLN02460  109 LRAAHKRtgqpgLIAEVKKASPSRGVLRENFDPVEIAQAYeKGGAACLSVLTDEKYFQGSFENLEAIRNAgVKCPLLCKE 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 160 FMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVLTEVSNEEELTRAIDL-GAPVIGINNRDLRDLSVD 238
Cdd:PLN02460  189 FIVDAWQIYYARSKGADAILLIAAVLPDLDIKYMLKICKSLGMAALIEVHDEREMDRVLGIeGVELIGINNRSLETFEVD 268

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1071011050 239 LARTRQLAARIPGDRV------VISESGINHRAQVAALRHHA-KGFLVGSSLMAEPDLEAAVRKL 296
Cdd:PLN02460  269 ISNTKKLLEGERGEQIrekgiiVVGESGLFTPDDVAYVQNAGvKAVLVGESLVKQDDPGKGIAGL 333
PRK01222 PRK01222
phosphoribosylanthranilate isomerase;
302-499 3.24e-55

phosphoribosylanthranilate isomerase;


Pssm-ID: 234923  Cd Length: 210  Bit Score: 183.85  E-value: 3.24e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 302 KVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPL--SYVGVFRNAQPATIAKTVDALGLAAVQLHG 379
Cdd:PRK01222    6 KICGITTPEDAEAAAELGADAIGFVFYPKSPRYVSPEQAAELAAALPPfvKVVGVFVNASDEEIDEIVETVPLDLLQLHG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 380 DEDAAYVEALRALLpaGCQIWKAVGVTSGEPLPAL--DYP-ADRLLLDTKVgSQSGGTGQAFDWTLLAGLDKSKLMLAGG 456
Cdd:PRK01222   86 DETPEFCRQLKRRY--GLPVIKALRVRSAGDLEAAaaYYGdADGLLLDAYV-GLPGGTGKTFDWSLLPAGLAKPWILAGG 162

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1071011050 457 LNPDNALEA-ARVGCVGLDFNSGVESAPGRKDAHKLAAAFGALR 499
Cdd:PRK01222  163 LNPDNVAEAiRQVRPYGVDVSSGVESAPGIKDPEKIRAFIEAVK 206
PRAI pfam00697
N-(5'phosphoribosyl)anthranilate (PRA) isomerase;
301-495 8.86e-54

N-(5'phosphoribosyl)anthranilate (PRA) isomerase;


Pssm-ID: 395566  Cd Length: 193  Bit Score: 179.46  E-value: 8.86e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 301 NKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAPLSYVGVFRNAQPATIAKTVDALGLAAVQLHGD 380
Cdd:pfam00697   1 AKICGLTRLSDVKAAVKAGADYLGLIFSESSKRQVSPEQAQELRSPVPLLLVGVFVNQPIDDVLRIAQVLGLDVVQLHGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 381 EDAAYVEALRALLPAGCQIWKAVGVtsGEPLPALDYP-ADRLLLDtkvgSQSGGTGQAFDWTLLAGLDKS--KLMLAGGL 457
Cdd:pfam00697  81 EDQEYENLLPTGVPVIKAIWVPDSV--DTVDIARRADhVDLPLLD----SGAGGTGELFDWSLVSKWLKSglKVILAGGL 154

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1071011050 458 NPDNALEAAR-VGCVGLDFNSGVESApGRKDAHKLAAAF 495
Cdd:pfam00697 155 NPDNVVEAIKtPGVIGVDVSSGVETN-GIKDLNKIRKFV 192
PRK13957 PRK13957
indole-3-glycerol-phosphate synthase; Provisional
 48-292 2.62e-43

indole-3-glycerol-phosphate synthase; Provisional


Pssm-ID: 140013  Cd Length: 247  Bit Score: 153.50  E-value: 2.62e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  48 ILGKIVAAKQEWVAARKESQPLASFQDALtpsdRDfegDLRQGSTRFILECKKASPSKGLIRNDFSPEAIADIYGHY-AT 126
Cdd:PRK13957    4 VLREIIETKQNEIEKISRWDPLPDRGLPL----RD---SLKSRSFSIIAECKRKSPSAGELRADYHPVQIAKTYETLgAS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 127 AISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGLGVLT 206
Cdd:PRK13957   77 AISVLTDQSYFGGSLEDLKSVSSELKIPVLRKDFILDEIQIREARAFGASAILLIVRILTPSQIKSFLKHASSLGMDVLV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 207 EVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAALRHHAKGFLVGSSLMAE 286
Cdd:PRK13957  157 EVHTEDEAKLALDCGAEIIGINTRDLDTFQIHQNLVEEVAAFLPPNIVKVGESGIESRSDLDKFRKLVDAALIGTYFMEK 236


                  ....*.
gi 1071011050 287 PDLEAA 292
Cdd:PRK13957  237 KDIRKA 242
PRK13802 PRK13802
bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional
 47-303 2.58e-41

bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 184335 [Multi-domain]  Cd Length: 695  Bit Score: 157.50  E-value: 2.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050  47 TILGKIVAAKQEWVAARKESQPLASF--QDALTPSDRDFEGDLRQGS-TRFILECKKASPSKGLIRNDFSPEAIADIYGH 123
Cdd:PRK13802    2 SVLDELVAGALEDQRTRELTVSLEEVkkAAAAAPAPIDATRWLKRADgIPVIAEIKRASPSKGHLSDIPDPAALAREYEQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 124 Y-ATAISVLTDEKFFQGDFAFLPRVRGRVQQPVLCKDFMIDPYQVYLARHYQADAILLMLSVLTDEGYRALFKVAKELGL 202
Cdd:PRK13802   82 GgASAISVLTEGRRFLGSLDDFDKVRAAVHIPVLRKDFIVTDYQIWEARAHGADLVLLIVAALDDAQLKHLLDLAHELGM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 203 GVLTEVSNEEELTRAIDLGAPVIGINNRDLRDLSVDLARTRQLAARIPGDRVVISESGINHRAQVAAL-RHHAKGFLVGS 281
Cdd:PRK13802  162 TVLVETHTREEIERAIAAGAKVIGINARNLKDLKVDVNKYNELAADLPDDVIKVAESGVFGAVEVEDYaRAGADAVLVGE 241

                         250       260
                  ....*....|....*....|..
gi 1071011050 282 SLMAEPDLEAAVRKLVLGQNKV 303
Cdd:PRK13802  242 GVATADDHELAVERLVKAGARV 263
PLN02363 PLN02363
phosphoribosylanthranilate isomerase
 294-501 6.71e-25

phosphoribosylanthranilate isomerase


Pssm-ID: 215207  Cd Length: 256  Bit Score: 103.40  E-value: 6.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 294 RKLVlgqnKVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYVDIPAARAVMAGAP---LSYVGVFRNAQPATIAKTVDAL 370
Cdd:PLN02363   46 RPLV----KMCGITSARDAAMAVEAGADFIGMILWPKSKRSISLSVAKEISQVAReggAKPVGVFVDDDANTILRAADSS 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 371 GLAAVQLHGDEDAAYVEALRALLPAGCQIWKAVGVTSGEPLPALD-YPADRLLLDtkvgSQSGGTGQAFDWT---LLAGL 446
Cdd:PLN02363  122 DLELVQLHGNGSRAAFSRLVRERKVIYVLNANEDGKLLNVVPEEDcHLADWILVD----SATGGSGKGFNWQnfkLPSVR 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1071011050 447 DKSKLMLAGGLNPDN---ALEAARVGcvGLDFNSGVESAPG-RKDAHKLAAAFGALRQL 501
Cdd:PLN02363  198 SRNGWLLAGGLTPENvheAVSLLKPT--GVDVSSGICGPDGiRKDPSKISSFISAVKSV 254
PRK13803 PRK13803
bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional
 302-501 1.02e-18

bifunctional phosphoribosylanthranilate isomerase/tryptophan synthase subunit beta; Provisional


Pssm-ID: 237513 [Multi-domain]  Cd Length: 610  Bit Score: 89.10  E-value: 1.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 302 KVCGLTRPEHAAAAHQAGAVFGGLIFVAKSPRYV--DIPAARAVMA--GAPLSYVGVFRNAQPATIAKTVDALGLAAVQL 377
Cdd:PRK13803    6 KICGIKDSALISKAVDMLPDFIGFIFYEKSPRFVgnKFLAPNLEKAirKAGGRPVGVFVNESAKAMLKFSKKNGIDFVQL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 378 HGDEDAAYVEALRALLPAGCQIWKAVGVTSGEPLPALDY---PADRLLLDTKVgSQSGGTGQAFDWTLLAGLD-KSKLML 453
Cdd:PRK13803   86 HGAESKAEPAYCQRIYKKSIKKIGSFLIDDAFGFEVLDEyrdHVKYFLFDNKT-KIYGGSGKSFDWEKFYNYNfKFPFFL 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1071011050 454 AGGLNPDN---ALEAARVGCVGLDFNSGVESAPGRKDAHKLAAAFGALRQL 501
Cdd:PRK13803  165 SGGLSPTNfdrIINLTHPQILGIDVSSGFEDSPGNKKLTLLKSFITNVKKK 215
PRK13958 PRK13958
N-(5'-phosphoribosyl)anthranilate isomerase; Provisional
 324-493 7.28e-18

N-(5'-phosphoribosyl)anthranilate isomerase; Provisional


Pssm-ID: 184418  Cd Length: 207  Bit Score: 82.08  E-value: 7.28e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 324 GLIFVAKSPRYVDIPAARAVMAGAP--LSYVGVFRNAQPATIAKTVDALGLAAVQLHGDEDAAYVEALRALLPaGCQIWK 401
Cdd:PRK13958   26 GFIHYEKSKRHQTITQIKKLASAVPnhIDKVCVVVNPDLTTIEHILSNTSINTIQLHGTESIDFIQEIKKKYS-SIKIIK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1071011050 402 AVGVTSgEPLPALDY---PADRLLLDTKvgSQS-GGTGQAFDWTLLAGLDKSKLMLAGGLNPDN--ALEAARVGCVGLDF 475
Cdd:PRK13958  105 ALPADE-NIIQNINKykgFVDLFIIDTP--SVSyGGTGQTYDWTILKHIKDIPYLIAGGINSENiqTVEQLKLSHQGYDI 181

                         170
                  ....*....|....*...
gi 1071011050 476 NSGVESApGRKDAHKLAA 493
Cdd:PRK13958  182 ASGIETN-GRKDINKMTA 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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