|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
20-840 |
0e+00 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 818.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 20 EAVWDSFTAWTQSRGISLYEAQEEASLALLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFAL 99
Cdd:COG4581 9 DARLEALADFAEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 100 CEIFGAENVGMMTGDATVNSGAPIIAATAEIVANIALREGEHAK-IQQVIMDEFHYYSEPDRGWAWQVPLLELP-QAQFL 177
Cdd:COG4581 89 VERFGAENVGLLTGDASVNPDAPIVVMTTEILRNMLYREGADLEdVGVVVMDEFHYLADPDRGWVWEEPIIHLPaRVQLV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 178 LMSATLGETAWIEKDLTERTGrPTTYVGGSERPVPLDFSYVFSP-----------------VHETIEELLADNKAPIYVV 240
Cdd:COG4581 169 LLSATVGNAEEFAEWLTRVRG-ETAVVVSEERPVPLEFHYLVTPrlfplfrvnpellrppsRHEVIEELDRGGLLPAIVF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 241 HFSQREAAERAQALTSMKIITAEEKQRIAEEIGNF--RFTTTFGKTLSRLLRKGIGIHHAGMLPKYRRLVEKLSQTGLLK 318
Cdd:COG4581 248 IFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEFaeDFSVLFGKTLSRLLRRGIAVHHAGMLPKYRRLVEELFQAGLLK 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 319 VICGTDTLGVGINVPIRTVLITGLAKYDGTKQRILKSREFHQIAGRAGRAGYDTEGTVVVEAPEHeienaklrrrvgDDP 398
Cdd:COG4581 328 VVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDTEGHVVVLAPEH------------DDP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 399 krlkklnkksardgevtwseKTFQRLTTAEPEELTSQFQVSNSMLLNVIARPgdGYEHMKHLIRSNH---DTRAKQNRDI 475
Cdd:COG4581 396 --------------------KKFARLASARPEPLRSSFRPSYNMVLNLLARP--GLERARELLEDSFaqfQADRSVVGLA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 476 LTAVDLFRGLiqADIVERTPDSPAyrpytltrELDRDFALNQPLSPfalafLTVLDPESSTYSLDVISAFEAILDDPRQV 555
Cdd:COG4581 454 RRARELERAL--AGVVERLACDLG--------DLQEYFALRQPLSP-----LEALERESPAYALDVVSVPEATLEDPRPV 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 556 LQAQQSAARGEEIAALKAEgVDYTERMALIEDVTYPQPLAE-ELEDAFETYCSSNPWAKEWQLSPKSVVRDMiehaMTFS 634
Cdd:COG4581 519 LLAQDRRARGEAAAAMKAA-IEYDERMERLEEVLRPHPLHEcPLERAFELYRETHPWVRDIELRPKSVARDF----DRFC 593
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 635 DLIATYGL-----SRSEGVVLRYLTDAWRTLSHSVPEAYMTEELEDIIVWLGELIRQVDSSlidEWATLadddapisqdv 709
Cdd:COG4581 594 ELLREYGYlddltLTSEGLLLRYLYDAAEALRQGVPDDLDPEELAALISWLVEEVRRVDSS---EWERL----------- 659
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 710 ldrelafgvedPTAltANRRAFkIMVRNYFFRLvelfaFEKEEALEsmLEYLDPDVRPDWPSLLDdyfdeYDDVMIDADA 789
Cdd:COG4581 660 -----------PSP--ANRRAF-VLVNALFRRL-----ELLERRHG--LPELDPGLAGAWASGAD-----LAEVLDATDL 713
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|.
gi 1084273445 790 rgpeyfrvkDESSRLWEVVQIVkDPDGDRSFQFHGVVDLdasDEAGEVRLR 840
Cdd:COG4581 714 ---------DAGDFVRWVRQVI-DPDPELRRTARAAVDL---IRRGVVAYS 751
|
|
| DUF3516 |
pfam12029 |
Domain of unknown function (DUF3516); This presumed domain is functionally uncharacterized. ... |
380-844 |
0e+00 |
|
Domain of unknown function (DUF3516); This presumed domain is functionally uncharacterized. This domain is found in bacteria. This domain is typically between 460 to 473 amino acids in length. This domain is found associated with pfam00270, pfam00271.
Pssm-ID: 432273 Cd Length: 460 Bit Score: 776.72 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 380 APEHEIENAKLRRRVGDDPKRLKKLNKKSARDGEVTWSEKTFQRLTTAEPEELTSQFQVSNSMLLNVIARPGDGYEHMKH 459
Cdd:pfam12029 1 APEHVIENARALAKAGDDPKKLKKVVKKKAPEGFVSWSEKTFERLIAAEPEPLTSRFRVSHSMLLNVLARPGDGFAAMRH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 460 LIRSNHDTRAKQNRDILTAVDLFRGLIQADIVER--TPDSPAyRPYTLTRELDRDFALNQPLSPFALAFLTVLDPESSTY 537
Cdd:pfam12029 81 LLTDNHEPRARQRRLIRRAIAIYRSLLDAGVVERlpEPDPTG-RRVRLTVDLQRDFALNQPLSPFALAALELLDPESPTY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 538 SLDVISAFEAILDDPRQVLQAQQSAARGEEIAALKAEGVDYTERMALIEDVTYPQPLAEELEDAFETYCSSNPWAKEWQL 617
Cdd:pfam12029 160 ALDVVSVIEATLEDPRQVLRAQQKKARGEAVAAMKAEGVEYDERMELLEEVTYPKPLAELLEAAFETYRRGHPWVADFEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 618 SPKSVVRDMIEHAMTFSDLIATYGLSRSEGVVLRYLTDAWRTLSHSVPEAYMTEELEDIIVWLGELIRQVDSSLIDEWAT 697
Cdd:pfam12029 240 SPKSVVRDMYERAMTFSEYVAFYGLARSEGVVLRYLTDAYRALRQTVPEEARTEELEDLIEWLGELVRQVDSSLLDEWEA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 698 LADDDAPISQDVLDRELafgvedPTALTANRRAFKIMVRNYFFRLVELFAFEKEEALESMLEYLDPDVrPDWPSLLDDYF 777
Cdd:pfam12029 320 LADPAAPLADEAVAAEA------PRPVTANRRAFRVMVRNAMFRRVELAAREDYDELAELDADLGWDA-DRWADALDPYF 392
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084273445 778 DEYDDVMIDADARGPEYFRVKDE-SSRLWEVVQIVKDPDGDRSFQFHGVVDLDASDEAGEVRLRDLDV 844
Cdd:pfam12029 393 DEHDDIGTGPDARGPALFLIDESpGGRTWRVRQILDDPEGDHDWGIDAEVDLDASDEAGEVVLRVLRV 460
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
32-410 |
3.05e-61 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 216.30 E-value: 3.05e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 32 SRGI-SLYEAQEEA-SLALLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIFGAEN-- 107
Cdd:COG1204 17 ERGIeELYPPQAEAlEAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFKRDFEELGik 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 108 VGMMTGDATVNSGAP----IIAATAEIVANIaLREGEH--AKIQQVIMDEFHYYSEPDRGwawqvPLLEL---------P 172
Cdd:COG1204 97 VGVSTGDYDSDDEWLgrydILVATPEKLDSL-LRNGPSwlRDVDLVVVDEAHLIDDESRG-----PTLEVllarlrrlnP 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 173 QAQFLLMSATLG---ETA-WIEKDLtertgrpttyVGGSERPVPLDFSYVFSPVHETIEELLADNKAPIYVVH------- 241
Cdd:COG1204 171 EAQIVALSATIGnaeEIAeWLDAEL----------VKSDWRPVPLNEGVLYDGVLRFDDGSRRSKDPTLALALdlleegg 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 242 ----F--SQREA---AERAQALTSMKIITAEEKQ--RIAEEIGNFRFTTTFGKTLSRLLRKGIGIHHAGMLPKYRRLVEK 310
Cdd:COG1204 241 qvlvFvsSRRDAeslAKKLADELKRRLTPEEREEleELAEELLEVSEETHTNEKLADCLEKGVAFHHAGLPSELRRLVED 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 311 LSQTGLLKVICGTDTLGVGINVPIRTVLITglaKYDGTKQRILKSREFHQIAGRAGRAGYDTEGTVVVEAPEHEIENAKL 390
Cdd:COG1204 321 AFREGLIKVLVATPTLAAGVNLPARRVIIR---DTKRGGMVPIPVLEFKQMAGRAGRPGYDPYGEAILVAKSSDEADELF 397
|
410 420
....*....|....*....|..
gi 1084273445 391 RRRVGDDPKRL--KKLNKKSAR 410
Cdd:COG1204 398 ERYILGEPEPIrsKLANESALR 419
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
31-497 |
7.70e-41 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 160.89 E-value: 7.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 31 QSRGI-SLYEAQEEASLA-LLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKF--FALCEIFGAe 106
Cdd:PRK02362 17 EAEGIeELYPPQAEAVEAgLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFeeFERFEELGV- 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 107 NVGMMTGDATVNSGA----PIIAATAEIVANIaLREGEH--AKIQQVIMDEFHYYSEPDRGWAWQVPLLEL----PQAQF 176
Cdd:PRK02362 96 RVGISTGDYDSRDEWlgdnDIIVATSEKVDSL-LRNGAPwlDDITCVVVDEVHLIDSANRGPTLEVTLAKLrrlnPDLQV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 177 LLMSATLG---ETA-WIEKDLTERTGRPTT-----------YVGGSERPVPLDFSY-VFSPVHETIEE----LLADNkap 236
Cdd:PRK02362 175 VALSATIGnadELAdWLDAELVDSEWRPIDlregvfyggaiHFDDSQREVEVPSKDdTLNLVLDTLEEggqcLVFVS--- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 237 iyvvhfSQR--EAAERAQALTSMKIITAEEKQR---IAEEIGNFRFTTTfGKTLSRLLRKGIGIHHAGMLPKYRRLVEKL 311
Cdd:PRK02362 252 ------SRRnaEGFAKRAASALKKTLTAAERAElaeLAEEIREVSDTET-SKDLADCVAKGAAFHHAGLSREHRELVEDA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 312 SQTGLLKVICGTDTLGVGINVPIRTVLITGLAKYDGTK-QRILKSREFHQIAGRAGRAGYDTEGTVVVEAPEHEienakl 390
Cdd:PRK02362 325 FRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGAgMQPIPVLEYHQMAGRAGRPGLDPYGEAVLLAKSYD------ 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 391 rrrvgddpkrlkklnkksardgEVtwsEKTFQRLTTAEPEELTSQFQVSNSMLLNVIARPGDGYEH-----MKHLIRSNH 465
Cdd:PRK02362 399 ----------------------EL---DELFERYIWADPEDVRSKLATEPALRTHVLSTIASGFARtrdglLEFLEATFY 453
|
490 500 510
....*....|....*....|....*....|...
gi 1084273445 466 DTRAKQNRDILTAVD-LFRGLIQADIVERTPDS 497
Cdd:PRK02362 454 ATQTDDTGRLERVVDdVLDFLERNGMIEEDGET 486
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
36-197 |
3.60e-35 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 132.00 E-value: 3.60e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 36 SLYEAQEEA-SLALLAGDNVILATPTGSGKSMVANAAHFIAMAR-GQRSFYTAPIKALVSEKFFALCEIFG--AENVGMM 111
Cdd:cd17921 1 LLNPIQREAlRALYLSGDSVLVSAPTSSGKTLIAELAILRALATsGGKAVYIAPTRALVNQKEADLRERFGplGKNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 112 TGDATVN----SGAPIIAATAEIvANIALREGEHAKIQQ---VIMDEFHYYSEPDRGWAWQVPLLEL----PQAQFLLMS 180
Cdd:cd17921 81 TGDPSVNklllAEADILVATPEK-LDLLLRNGGERLIQDvrlVVVDEAHLIGDGERGVVLELLLSRLlrinKNARFVGLS 159
|
170 180
....*....|....*....|.
gi 1084273445 181 ATLGE----TAWIEKDLTERT 197
Cdd:cd17921 160 ATLPNaedlAEWLGVEDLIRF 180
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
33-414 |
7.21e-34 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 139.18 E-value: 7.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 33 RGI-SLYEAQEEA-SLALLAGDNVILATPTGSGKSMVANaahfIAMA-----RGQRSFYTAPIKALVSEKF--FALCEIF 103
Cdd:PRK00254 19 RGIeELYPPQAEAlKSGVLEGKNLVLAIPTASGKTLVAE----IVMVnkllrEGGKAVYLVPLKALAEEKYreFKDWEKL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 104 GAEnVGMMTGDATVNS----GAPIIAATAEIVANIaLREGEH--AKIQQVIMDEFHYYSEPDRGWAWQVPLLE-LPQAQF 176
Cdd:PRK00254 95 GLR-VAMTTGDYDSTDewlgKYDIIIATAEKFDSL-LRHGSSwiKDVKLVVADEIHLIGSYDRGATLEMILTHmLGRAQI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 177 LLMSATLG---ETA-WIEKDLTERTGRPTTYV-------------GGSERpvpldfsyvfspVHETIEELLAD--NKAPI 237
Cdd:PRK00254 173 LGLSATVGnaeELAeWLNAELVVSDWRPVKLRkgvfyqgflfwedGKIER------------FPNSWESLVYDavKKGKG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 238 YVVHFSQREAAERAQALTSMKI---ITAEEKQRIAEEIGNFRFTTTFGKtLSRLLRKGIGIHHAGMLPKYRRLVEKLSQT 314
Cdd:PRK00254 241 ALVFVNTRRSAEKEALELAKKIkrfLTKPELRALKELADSLEENPTNEK-LKKALRGGVAFHHAGLGRTERVLIEDAFRE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 315 GLLKVICGTDTLGVGINVPIRTVLITGLAKYDGTKQRILKSREFHQIAGRAGRAGYDTEGTVVVEAPEHEIENAKLRRRV 394
Cdd:PRK00254 320 GLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFGWEDIPVLEIQQMMGRAGRPKYDEVGEAIIVATTEEPSKLMERYIF 399
|
410 420
....*....|....*....|
gi 1084273445 395 GDDPKRLKKLNKKSARDGEV 414
Cdd:PRK00254 400 GKPEKLFSMLSNESAFRSQV 419
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
209-378 |
8.06e-33 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 124.20 E-value: 8.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 209 RPVPLDFSYVFSPVHETIEELLADNKAPIYVVHF-SQREAAERAQALTsmkiitaeekqriaeeignFRFTTTFGKTLSR 287
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKFDSDIIVLlKIETVSEGKPVLV-------------------FCSSRKECEKTAK 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 288 LLRkGIGIHHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVPIRTVLITGLAKYDGTKQRILKSREFHQIAGRAGR 367
Cdd:cd18795 62 DLA-GIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGR 140
|
170
....*....|.
gi 1084273445 368 AGYDTEGTVVV 378
Cdd:cd18795 141 PGFDTRGEAII 151
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
24-374 |
1.08e-27 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 119.60 E-value: 1.08e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 24 DSFTAWTQSRGISLYEAQEEASLALLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIf 103
Cdd:PRK01172 10 DEFLNLFTGNDFELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELSRL- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 104 gaENVGMMTGDATVNSGAP--------IIAATAEIVANIALREGEHAK-IQQVIMDEFHYYSEPDRGwawqvPLLEL--- 171
Cdd:PRK01172 89 --RSLGMRVKISIGDYDDPpdfikrydVVILTSEKADSLIHHDPYIINdVGLIVADEIHIIGDEDRG-----PTLETvls 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 172 ------PQAQFLLMSATLGETAWIEKDLTERTgrpttyVGGSERPVPLDF-----------SYVFSPVHET--IEELLAD 232
Cdd:PRK01172 162 saryvnPDARILALSATVSNANELAQWLNASL------IKSNFRPVPLKLgilyrkrlildGYERSQVDINslIKETVND 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 233 N-KAPIYVvhfSQREAAERaqaltsmkiiTAEEKQRIAEEIGNFRF----TTTFGKTLSRLLRKGIGIHHAGMLPKYRRL 307
Cdd:PRK01172 236 GgQVLVFV---SSRKNAED----------YAEMLIQHFPEFNDFKVssenNNVYDDSLNEMLPHGVAFHHAGLSNEQRRF 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084273445 308 VEKLSQTGLLKVICGTDTLGVGINVPIRTVLITGLAKYDGTKQRILKSREFHQIAGRAGRAGYDTEG 374
Cdd:PRK01172 303 IEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYG 369
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
41-183 |
6.89e-25 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 103.29 E-value: 6.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 41 QEEASLALLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIFGaeNVGMMTGDATVNSG 120
Cdd:cd18024 37 QKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIYTSPIKALSNQKYRELQEEFG--DVGLMTGDVTINPN 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084273445 121 APIIAATAEIVANIALREGEHAK-IQQVIMDEFHYYSEPDRGWAWQVPLLELPQA-QFLLMSATL 183
Cdd:cd18024 115 ASCLVMTTEILRSMLYRGSEIMReVAWVIFDEIHYMRDKERGVVWEETIILLPDKvRYVFLSATI 179
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
41-204 |
8.82e-25 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 101.96 E-value: 8.82e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 41 QEEASLALLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIFGaeNVGMMTGDATVNSG 120
Cdd:cd18027 13 QKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFG--DVGLITGDVQLNPE 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 121 APIIAATAEIVANIALREGEHAK-IQQVIMDEFHYYSEPDRGWAWQVPLLELPQ-AQFLLMSATLGETA----WIekdlt 194
Cdd:cd18027 91 ASCLIMTTEILRSMLYNGSDVIRdLEWVIFDEVHYINDAERGVVWEEVLIMLPDhVSIILLSATVPNTVefadWI----- 165
|
170
....*....|
gi 1084273445 195 ERTGRPTTYV 204
Cdd:cd18027 166 GRIKKKNIYV 175
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
8-369 |
6.36e-23 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 104.92 E-value: 6.36e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 8 ADLDDVPADLFEEAVwdsftAWTQSRGIS-LYEAQEEASLALLAGDNVILATPTGSGKSMVAN--AAHFIAMARGQRSFY 84
Cdd:COG1205 32 ARYAPWPDWLPPELR-----AALKKRGIErLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLlpVLEALLEDPGATALY 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 85 TAPIKALVS---EKFFALCEIFGAE-NVGMMTGDATVN------SGAPIIAATAEIVaNIALREGeHAKIQQ-------V 147
Cdd:COG1205 107 LYPTKALARdqlRRLRELAEALGLGvRVATYDGDTPPEerrwirEHPDIVLTNPDML-HYGLLPH-HTRWARffrnlryV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 148 IMDEFHYY-----------------------SEPdrgwawqvpllelpqaQFLLMSATLGETAwiekDLTER-TGRPTTY 203
Cdd:COG1205 185 VIDEAHTYrgvfgshvanvlrrlrricrhygSDP----------------QFILASATIGNPA----EHAERlTGRPVTV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 204 VGGS-----ER------PVPLDFSYVFSPVHETIeELLADnkapiYVVH------FSQ-REAAERaqaltsmkiiTAEEK 265
Cdd:COG1205 245 VDEDgsprgERtfvlwnPPLVDDGIRRSALAEAA-RLLAD-----LVREglrtlvFTRsRRGAEL----------LARYA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 266 QRIAEEignfrftttfgktlsRLLRKGIGIHHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVP-IRTVLITGlak 344
Cdd:COG1205 309 RRALRE---------------PDLADRVAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGgLDAVVLAG--- 370
|
410 420
....*....|....*....|....*
gi 1084273445 345 YDGTKQRilksreFHQIAGRAGRAG 369
Cdd:COG1205 371 YPGTRAS------FWQQAGRAGRRG 389
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
36-195 |
4.85e-21 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 91.24 E-value: 4.85e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 36 SLYEAQEEASLA-LLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKF--FALCEIFGAEnVGMMT 112
Cdd:cd18028 1 ELYPPQAEAVRAgLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEKYeeFKKLEEIGLK-VGIST 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 113 GD----ATVNSGAPIIAATAEIVANIaLREGEH--AKIQQVIMDEFHYYSEPDRGwawqvPLLEL---------PQAQFL 177
Cdd:cd18028 80 GDydedDEWLGDYDIIVATYEKFDSL-LRHSPSwlRDVGVVVVDEIHLISDEERG-----PTLESivarlrrlnPNTQII 153
|
170 180
....*....|....*....|..
gi 1084273445 178 LMSATLG---ETA-WIEKDLTE 195
Cdd:cd18028 154 GLSATIGnpdELAeWLNAELVE 175
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
38-187 |
2.25e-18 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 83.06 E-value: 2.25e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 38 YEAQEEASLALLAGDNVILATPTGSGKSMVAN---AAHFIAMARGQRSFYTAPIKAL---VSEKFFALCEIFGAENVGMM 111
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLlpaLEALDKLDNGPQALVLAPTRELaeqIYEELKKLGKGLGLKVASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 112 TGDATVN-----SGAPIIAATAEIVANIALREGEHAKIQQVIMDEFHYYSEPDRGWAWQVPLLELP-QAQFLLMSATLGE 185
Cdd:pfam00270 81 GGDSRKEqleklKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPkKRQILLLSATLPR 160
|
..
gi 1084273445 186 TA 187
Cdd:pfam00270 161 NL 162
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
31-378 |
1.79e-15 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 80.71 E-value: 1.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 31 QSRGISLYEAQeeaSLA----LLAGDNVILATPTGSGKSMVANAAHFIAMARGQRSF-YTAPIKALVSEKFfalcEIFGA 105
Cdd:COG1202 204 EGRGEELLPVQ---SLAvengLLEGKDQLVVSATATGKTLIGELAGIKNALEGKGKMlFLVPLVALANQKY----EDFKD 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 106 E-----NVGMMTGDATVNSG-------APIIAATAEIVANIaLREGEHAK-IQQVIMDEFHYYSEPDRGwawqvPLLE-- 170
Cdd:COG1202 277 RygdglDVSIRVGASRIRDDgtrfdpnADIIVGTYEGIDHA-LRTGRDLGdIGTVVIDEVHMLEDPERG-----HRLDgl 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 171 -------LPQAQFLLMSATLGETAWIEKDLTertgrpTTYVGGSERPVPLDFSYVFSPVHEtieelladnKAPIyvvhfs 243
Cdd:COG1202 351 iarlkyyCPGAQWIYLSATVGNPEELAKKLG------AKLVEYEERPVPLERHLTFADGRE---------KIRI------ 409
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 244 QREAAERAQALTSMK------IItaeekqriaeeignfrFTTTFGKT--LSRLLRKGIGIHHAGMLPKYRRLVEKLSQTG 315
Cdd:COG1202 410 INKLVKREFDTKSSKgyrgqtII----------------FTNSRRRCheIARALGYKAAPYHAGLDYGERKKVERRFADQ 473
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084273445 316 LLKVICGTDTLGVGINVPIRTVLITGLAKydGTKQriLKSREFHQIAGRAGRAGYDTEGTVVV 378
Cdd:COG1202 474 ELAAVVTTAALAAGVDFPASQVIFDSLAM--GIEW--LSVQEFHQMLGRAGRPDYHDRGKVYL 532
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
34-215 |
3.67e-14 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 72.14 E-value: 3.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 34 GISLYEAQEEASLALLAGD-NVILATPTGSGKSMVA--NAAHFIAMARGQRSFYTAPIKAL---VSEKFFALCEIFGAEN 107
Cdd:smart00487 6 FEPLRPYQKEAIEALLSGLrDVILAAPTGSGKTLAAllPALEALKRGKGGRVLVLVPTRELaeqWAEELKKLGPSLGLKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 108 VGMMTGDAT-------VNSGAPIIAATAEIVANIALREG-EHAKIQQVIMDEFHYYSEPDRGWAWQVPLLELP-QAQFLL 178
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPkNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....*..
gi 1084273445 179 MSATLGEtaWIEKDLTERTGRPTTYVGGSERPVPLDF 215
Cdd:smart00487 166 LSATPPE--EIENLLELFLNDPVFIDVGFTPLEPIEQ 200
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
318-377 |
1.45e-13 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 68.35 E-value: 1.45e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 318 KVICGTDTLGVGINVPIRTVLITGLAKYDGTKQRILKSREFHQIAGRAGRAGYDTEGTVV 377
Cdd:cd18805 72 DVLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSHFPEGEV 131
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
35-432 |
6.56e-12 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 68.90 E-value: 6.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 35 ISLYEAQEEASLALLA-----GDNVILATPTGSGKSMVanAAHFIA-MARGQRSFYTAPIKALVS------EKFFALCEI 102
Cdd:COG1061 79 FELRPYQQEALEALLAalergGGRGLVVAPTGTGKTVL--ALALAAeLLRGKRVLVLVPRRELLEqwaeelRRFLGDPLA 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 103 FGAENvgmmtgdatvNSGAPIIAATAEIVANIALREGEHAKIQQVIMDEFHYYSEPdrgwAWQVpLLELPQAQFLL-MSA 181
Cdd:COG1061 157 GGGKK----------DSDAPITVATYQSLARRAHLDELGDRFGLVIIDEAHHAGAP----SYRR-ILEAFPAAYRLgLTA 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 182 TLgetawiekdltERTGRpttyvggserpVPLDFSYVFSPVHE-TIEELLADN--KAPIYVVHFS-----QREAAERAQA 253
Cdd:COG1061 222 TP-----------FRSDG-----------REILLFLFDGIVYEySLKEAIEDGylAPPEYYGIRVdltdeRAEYDALSER 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 254 LTSMKIITAEEKQRIAEEI----GNFRFTTTFG------KTLSRLLRKgIGIH----HAGMLPKYR-RLVEKLSQtGLLK 318
Cdd:COG1061 280 LREALAADAERKDKILRELlrehPDDRKTLVFCssvdhaEALAELLNE-AGIRaavvTGDTPKKEReEILEAFRD-GELR 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 319 VICGTDTLGVGINVP-IRTVLITGlakydGTKQRilksREFHQIAGRAGRAGYDTEGTVVVE--APEHEIENAKLRRRVG 395
Cdd:COG1061 358 ILVTVDVLNEGVDVPrLDVAILLR-----PTGSP----REFIQRLGRGLRPAPGKEDALVYDfvGNDVPVLEELAKDLRD 428
|
410 420 430
....*....|....*....|....*....|....*..
gi 1084273445 396 DDPKRLKKLNKKSARDGEVTWSEKTFQRLTTAEPEEL 432
Cdd:COG1061 429 LAGYRVEFLDEEESEELALLIAVKPALEVKGELEEEL 465
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
51-182 |
7.55e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 63.96 E-value: 7.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 51 GDNVILATPTGSGKS-MVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIFGA-ENVGMMTGDAT-------VNSGA 121
Cdd:cd00046 1 GENVLITAPTGSGKTlAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRELFGPgIRVAVLVGGSSaeereknKLGDA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273445 122 PIIAATAEIVANIALREGEHAKIQQ--VIMDEFH---YYSEPDRGWAWQVPLLELPQAQFLLMSAT 182
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRLFLKDLklIIVDEAHallIDSRGALILDLAVRKAGLKNAQVILLSAT 146
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
283-369 |
7.84e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 58.76 E-value: 7.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 283 KTLSRLLRK---GIGIHHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVP-IRTVLITGLakyDGTKQrilksrEF 358
Cdd:smart00490 1 EELAELLKElgiKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---PWSPA------SY 71
|
90
....*....|.
gi 1084273445 359 HQIAGRAGRAG 369
Cdd:smart00490 72 IQRIGRAGRAG 82
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
20-200 |
9.04e-11 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 62.23 E-value: 9.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 20 EAVWDSFtawtQSRGI-SLYEAQEEA-SLA-LLAGDNVILATPTGSGKSMVANaahfIAMA-----RGQRSFYTAPIKAL 91
Cdd:cd18026 3 DAVREAY----AKKGIkKLYDWQKEClSLPgLLEGRNLVYSLPTSGGKTLVAE----ILMLkrlleRRKKALFVLPYVSI 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 92 VSEKFFALCEIFGAENV---GMMTGDAT---VNSGAPIIA-AT---AEIVANIALREGEHAKIQQVIMDEFHYYSEPDRG 161
Cdd:cd18026 75 VQEKVDALSPLFEELGFrveGYAGNKGRsppKRRKSLSVAvCTiekANSLVNSLIEEGRLDELGLVVVDELHMLGDGHRG 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1084273445 162 WawqvpLLELPQAQFLL----------MSATLGET----AWIEKDLTERTGRP 200
Cdd:cd18026 155 A-----LLELLLTKLLYaaqkniqivgMSATLPNLeelaSWLRAELYTTNFRP 202
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
37-185 |
9.32e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 58.75 E-value: 9.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 37 LYEAQEEASLALLAGDNVILATPTGSGKSMVANAAHFIAMAR--GQRSFYTAPIKALVS---EKFFAL-CEIFGAENVGM 110
Cdd:cd17923 1 LYSHQAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRdpGSRALYLYPTKALAQdqlRSLRELlEQLGLGIRVAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 111 MTGDATVNSGAPIIAATAEIV------ANIAL--REGEHAKIQQ----VIMDEFHYYsepdRG-WAWQVPLL-------- 169
Cdd:cd17923 81 YDGDTPREERRAIIRNPPRILltnpdmLHYALlpHHDRWARFLRnlryVVLDEAHTY----RGvFGSHVALLlrrlrrlc 156
|
170
....*....|....*...
gi 1084273445 170 --ELPQAQFLLMSATLGE 185
Cdd:cd17923 157 rrYGADPQFILTSATIGN 174
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
41-210 |
1.06e-08 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 56.21 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 41 QEEASLALLAGD-NVILATPTGSGKS------MVANAAHFIAMARGQR-SFYTAPIKALVSEKFFALCEIFG--AENVGM 110
Cdd:cd18023 6 QSEVFPDLLYSDkNFVVSAPTGSGKTvlfelaILRLLKERNPLPWGNRkVVYIAPIKALCSEKYDDWKEKFGplGLSCAE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 111 MTGDATVNS-----GAPIIAATAEIVANIALREGEHAK----IQQVIMDEFHYYSEPdRGWAWQVPL------------- 168
Cdd:cd18023 86 LTGDTEMDDtfeiqDADIILTTPEKWDSMTRRWRDNGNlvqlVALVLIDEVHIIKEN-RGATLEVVVsrmktlsssselr 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1084273445 169 -LELPQAQFLLMSATLGEtawIEkDLTE--RTGRPTTYVGGSE-RP 210
Cdd:cd18023 165 gSTVRPMRFVAVSATIPN---IE-DLAEwlGDNPAGCFSFGESfRP 206
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
52-171 |
5.83e-08 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 53.53 E-value: 5.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 52 DNVILATPTGSGKSMVANAAHFIAMAR--GQRSFYTAPIKALVSEKF----FALCEIFGaENVGMMTGDATVN----SGA 121
Cdd:cd18022 18 NNVLLGAPTGSGKTIAAELAMFRAFNKypGSKVVYIAPLKALVRERVddwkKRFEEKLG-KKVVELTGDVTPDmkalADA 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1084273445 122 PIIAATAE----IVANIALREgehaKIQQV---IMDEFHYYSEpDRGwawqvPLLEL 171
Cdd:cd18022 97 DIIITTPEkwdgISRSWQTRE----YVQQVsliIIDEIHLLGS-DRG-----PVLEV 143
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
283-369 |
6.41e-08 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 52.21 E-value: 6.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 283 KTLSRLLRKgIGIH----HAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVP-IRTVLITGLAkydgtkqrilKSRE 357
Cdd:cd18794 44 EQVAARLQS-KGISaaayHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPdVRFVIHYSLP----------KSME 112
|
90
....*....|...
gi 1084273445 358 -FHQIAGRAGRAG 369
Cdd:cd18794 113 sYYQESGRAGRDG 125
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
288-369 |
1.18e-07 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 50.67 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 288 LLRKGIGI--HHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVP-IRTVLITGLAKydgtkqrilKSREFHQIAGR 364
Cdd:pfam00271 34 LEKEGIKVarLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdVDLVINYDLPW---------NPASYIQRIGR 104
|
....*
gi 1084273445 365 AGRAG 369
Cdd:pfam00271 105 AGRAG 109
|
|
| recQ_fam |
TIGR00614 |
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are ... |
41-409 |
1.51e-06 |
|
ATP-dependent DNA helicase, RecQ family; All proteins in this family for which functions are known are 3'-5' DNA-DNA helicases. These proteins are used for recombination, recombinational repair, and possibly maintenance of chromosome stability. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129701 [Multi-domain] Cd Length: 470 Bit Score: 51.69 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 41 QEEASLALLAGDNVILATPTGSGKSMvanAAHFIAMARGQRSFYTAPIKALVSEKFFALcEIFGAENVgMMTGDATVNSG 120
Cdd:TIGR00614 16 QLEVINAVLLGRDCFVVMPTGGGKSL---CYQLPALYSDGITLVISPLISLMEDQVLQL-QALGIPAT-FLNSAQTKEQQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 121 API-----------IAATAE-IVANIALRE--GEHAKIQQVIMDEFHYYSEpdrgwaW---------QVPLLE--LPQAQ 175
Cdd:TIGR00614 91 LNVltdlkdgkiklLYVTPEkISASNRLLQtlEERKGITLIAVDEAHCISQ------WghdfrpdykALGSLKqkFPNVP 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 176 FLLMSATLGETawIEKDLTERTG--RPTTYVGGSERP-VPLDFSYVFSPVHETIEELL-ADNKAPIYVVH-FSQREAaer 250
Cdd:TIGR00614 165 VMALTATASPS--VREDILRQLNllNPQIFCTSFDRPnLYYEVRRKTPKILEDLLRFIrKEFEGKSGIIYcPSRKKV--- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 251 aqaltsmkiitaeekQRIAEEignfrftttfgktlsrLLRKGI--GIHHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGV 328
Cdd:TIGR00614 240 ---------------EQVAAE----------------LQKLGLaaGAYHAGLEDSARDDVQHKFQRDEIQVVVATVAFGM 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 329 GINVP-IRTVLITGLAkydgtkqrilKSRE-FHQIAGRAGRAGYDTEgTVVVEAPeHEIenAKLRRRVG---DDPKRLKK 403
Cdd:TIGR00614 289 GINKPdVRFVIHYSLP----------KSMEsYYQESGRAGRDGLPSE-CHLFYAP-ADM--NRLRRLLMeepDGNFRTYK 354
|
....*.
gi 1084273445 404 LNKKSA 409
Cdd:TIGR00614 355 LKLYEM 360
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
41-184 |
1.04e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 47.04 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 41 QEEASLALLAGDNVILATPTGSGKSMVA-----NAAHFIAMARGQRSFYTAPIKALVS---EKFFALCEIFGaENVGMMT 112
Cdd:cd17927 7 QLELAQPALKGKNTIICLPTGSGKTFVAvliceHHLKKFPAGRKGKVVFLANKVPLVEqqkEVFRKHFERPG-YKVTGLS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 113 GDATVNSGAP-------IIAATAEIVANiALREGEH---AKIQQVIMDEFHY------YSEPDRGWAWQVPLLELPQAQF 176
Cdd:cd17927 86 GDTSENVSVEqivessdVIIVTPQILVN-DLKSGTIvslSDFSLLVFDECHNttknhpYNEIMFRYLDQKLGSSGPLPQI 164
|
....*...
gi 1084273445 177 LLMSATLG 184
Cdd:cd17927 165 LGLTASPG 172
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
47-170 |
1.89e-05 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 46.59 E-value: 1.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 47 ALLAGDNVILATPTGSGKSMVANAA--HFIAMARGQRS---------FYTAPIKALVSE---KFFALCEIFGAEnVGMMT 112
Cdd:cd18019 29 AFETDENLLLCAPTGAGKTNVALLTilREIGKHRNPDGtinldafkiVYIAPMKALVQEmvgNFSKRLAPYGIT-VAELT 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084273445 113 GDATVN----SGAPIIAATAEIVANIALREGEHAKIQQV---IMDEFHYYSEpDRGwawqvPLLE 170
Cdd:cd18019 108 GDQQLTkeqiSETQIIVTTPEKWDIITRKSGDRTYTQLVrliIIDEIHLLHD-DRG-----PVLE 166
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
35-182 |
3.47e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 44.97 E-value: 3.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 35 ISLYEAQEEASLALLAG-----DNVILATPTGSGKSMVanAAHFIA----MARGQRSFYTAPIKALVS--EKFFALCEIF 103
Cdd:pfam04851 2 LELRPYQIEAIENLLESikngqKRGLIVMATGSGKTLT--AAKLIArlfkKGPIKKVLFLVPRKDLLEqaLEEFKKFLPN 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 104 GAENVGMMTGDATVNS--GAPIIAATAEIVANIALREGEHAKIQQ---VIMDEFHYYSEPdrgwAWQvPLLELPQAQFLL 178
Cdd:pfam04851 80 YVEIGEIISGDKKDESvdDNKIVVTTIQSLYKALELASLELLPDFfdvIIIDEAHRSGAS----SYR-NILEYFKPAFLL 154
|
....*
gi 1084273445 179 -MSAT 182
Cdd:pfam04851 155 gLTAT 159
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
52-153 |
5.36e-05 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 44.94 E-value: 5.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 52 DNVILATPTGSGKSMVANAA---HFIAMARGqRSFYTAPIKALVSEKFFALCEIFGA---ENVGMMTGDATVN----SGA 121
Cdd:cd18021 20 DNVFVGAPTGSGKTVCAELAllrHWRQNPKG-RAVYIAPMQELVDARYKDWRAKFGPllgKKVVKLTGETSTDlkllAKS 98
|
90 100 110
....*....|....*....|....*....|....*
gi 1084273445 122 PIIAATAEIVANIALREGEHAKIQQV---IMDEFH 153
Cdd:cd18021 99 DVILATPEQWDVLSRRWKQRKNVQSVelfIADELH 133
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
51-184 |
1.33e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 43.34 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 51 GDNVILATPTGSGKSMVANAAHFIAMARGQRS----FYTAPIKALVSEKFFAL---CEIFGAE-NVGMMTGDATVNSGAP 122
Cdd:cd17922 1 GRNVLIAAPTGSGKTEAAFLPALSSLADEPEKgvqvLYISPLKALINDQERRLeepLDEIDLEiPVAVRHGDTSQSEKAK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1084273445 123 IIAATAEIV-----------ANIALREgEHAKIQQVIMDEFHYYSEPDRGWAWQVpLLEL------PQAQFLLMSATLG 184
Cdd:cd17922 81 QLKNPPGILittpeslelllVNKKLRE-LFAGLRYVVVDEIHALLGSKRGVQLEL-LLERlrkltgRPLRRIGLSATLG 157
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
35-153 |
2.45e-04 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 43.23 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 35 ISLYEAQEEASLALLAGDNVILATPTGSGKSMVANAA---H---FIAMARGQRSFYTAPIKALV---SEKFFALCEifGA 105
Cdd:cd18036 1 LELRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYIcrhHlekRRSAGEKGRVVVLVNKVPLVeqqLEKFFKYFR--KG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 106 ENVGMMTGDATVNSGAP-------IIAATAEIVANIAL--REGEHAKIQQ---VIMDEFH 153
Cdd:cd18036 79 YKVTGLSGDSSHKVSFGqivkasdVIICTPQILINNLLsgREEERVYLSDfslLIFDECH 138
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
305-377 |
3.78e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 39.61 E-value: 3.78e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084273445 305 RRLVEKLSQtgLLKVICGTDTLGVGINVP-IRTVLITGLAKYdgtkqrilkSREFHQIAGRAGRAGYDtEGTVV 377
Cdd:cd18785 13 IEHAEEIAS--SLEILVATNVLGEGIDVPsLDTVIFFDPPSS---------AASYIQRVGRAGRGGKD-EGEVI 74
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
37-183 |
1.23e-03 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 39.98 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 37 LYEAQEEA---SLALLAGDNVILATPTGSGKSMVANAAhfIAMARGQRSFYTAPIKALV---SEKFFALceiFGAENVGM 110
Cdd:cd17926 1 LRPYQEEAleaWLAHKNNRRGILVLPTGSGKTLTALAL--IAYLKELRTLIVVPTDALLdqwKERFEDF---LGDSSIGL 75
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084273445 111 MTGDAT-VNSGAPIIAATAEIVANIALREGEHAKIQ-QVIMDEFHYYSEPdrgwAWQVPLLELPQAQFLLMSATL 183
Cdd:cd17926 76 IGGGKKkDFDDANVVVATYQSLSNLAEEEKDLFDQFgLLIVDEAHHLPAK----TFSEILKELNAKYRLGLTATP 146
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
296-369 |
1.66e-03 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 42.19 E-value: 1.66e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273445 296 HHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINVP-IRTVLITGLAkydgtkqrilKSRE-FHQIAGRAGRAG 369
Cdd:PLN03137 710 YHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPdVRFVIHHSLP----------KSIEgYHQECGRAGRDG 775
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
54-172 |
3.40e-03 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 38.69 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 54 VILATPTGSGKSMVAnaahFIAMARGQRSFYTAPIKALVSEKFfalcEIFGAENV--GMMTGDATV-NSGAPIIAATAEI 130
Cdd:cd17913 4 IFHAGPTNSGKTYHA----LQRLKSAKSGVYCGPLRLLAWEVY----ERLNAEGVpcDLVTGQERReVEGATHVSCTVEM 75
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1084273445 131 vANIalregeHAKIQQVIMDEFHYYSEPDRGWAWQVPLLELP 172
Cdd:cd17913 76 -ASI------SEPYDVAVIDEIQMIGDPQRGWAWTRALLGLP 110
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
40-182 |
6.38e-03 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 38.55 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 40 AQEEASLALLAGDnvilatpTGSGKSMVANAAHFIAMARGQRSFYTAPIKALVSEKFFALCEIFGAENVGMMTGD--ATV 117
Cdd:cd17918 32 HSPEPMDRLLSGD-------VGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKFLPFINVELVTGGtkAQI 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084273445 118 NSGAPIIAATAEIvanIALREGEHaKIQQVIMDEFHYYSEPDRGwawqvPLLELPQAQFLLMSAT 182
Cdd:cd17918 105 LSGISLLVGTHAL---LHLDVKFK-NLDLVIVDEQHRFGVAQRE-----ALYNLGATHFLEATAT 160
|
|
| SF2_C_Hrq |
cd18797 |
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ... |
266-378 |
7.02e-03 |
|
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350184 [Multi-domain] Cd Length: 146 Bit Score: 38.01 E-value: 7.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273445 266 QRIAEEIgnFRFTTTFGKTLSRLLRKgIGIHHAGMLPKYRRLVEKLSQTGLLKVICGTDTLGVGINV-PIRTVLITGlak 344
Cdd:cd18797 45 RKLAELL--LRYLKARLVEEGPLASK-VASYRAGYLAEDRREIEAELFNGELLGVVATNALELGIDIgGLDAVVLAG--- 118
|
90 100 110
....*....|....*....|....*....|....
gi 1084273445 345 YDGTkqriLKSreFHQIAGRAGRAGYDTEGTVVV 378
Cdd:cd18797 119 YPGS----LAS--LWQQAGRAGRRGKDSLVILVA 146
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