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Conserved domains on  [gi|1084273828|ref|WP_070362728|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Corynebacterium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-89 2.65e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 2.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273828   3 TIASRLDVMNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHL 82
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                  ....*..
gi 1084273828  83 ATALNAL 89
Cdd:COG0640    82 AELLEWL 88
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-89 2.65e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 2.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273828   3 TIASRLDVMNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHL 82
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                  ....*..
gi 1084273828  83 ATALNAL 89
Cdd:COG0640    82 AELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-86 2.50e-20

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 77.89  E-value: 2.50e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  11 MNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHLATAL 86
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-89 1.35e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.49  E-value: 1.35e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  15 GRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIAD-PHLATALNAL 89
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-90 6.27e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 69.16  E-value: 6.27e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828   25 RILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHLATALNALV 90
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 20-64 2.49e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 56.68  E-value: 2.49e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1084273828  20 DPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIV 64
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
3-89 2.65e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 88.41  E-value: 2.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273828   3 TIASRLDVMNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHL 82
Cdd:COG0640     2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81


                  ....*..
gi 1084273828  83 ATALNAL 89
Cdd:COG0640    82 AELLEWL 88
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 11-86 2.50e-20

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 77.89  E-value: 2.50e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  11 MNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHLATAL 86
Cdd:NF033788    1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 15-89 1.35e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 73.49  E-value: 1.35e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  15 GRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIAD-PHLATALNAL 89
Cdd:cd00090     1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDaERLLALLESL 76
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
25-90 6.27e-17

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 69.16  E-value: 6.27e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828   25 RILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADPHLATALNALV 90
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
17-80 1.31e-13

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 62.97  E-value: 1.31e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084273828  17 AMADPTRSRILMTLLDGPS-YPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIADP 80
Cdd:COG3398    93 YLRRETPRRILLYLLENPGaTNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPP 157
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 20-64 2.49e-12

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 56.68  E-value: 2.49e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1084273828  20 DPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIV 64
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
6-82 1.65e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 56.58  E-value: 1.65e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273828   6 SRLDVMNRLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGR-----KTRYEIADP 80
Cdd:COG1777     2 SDDEDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGRedgraRKYYRLSAF 81


                  ..
gi 1084273828  81 HL 82
Cdd:COG1777    82 RL 83
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
13-77 3.45e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 52.65  E-value: 3.45e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  13 RLGRAMADPTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPE-GRKTRYEI 77
Cdd:COG4189    11 EVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKpGKRGRQKI 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 16-71 5.77e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.69  E-value: 5.77e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1084273828  16 RAMADPTRSRILMTLL-DGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGR 71
Cdd:pfam12840   5 EALADPTRLRILRALVgDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
21-75 2.21e-06

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 43.71  E-value: 2.21e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1084273828  21 PTRSRILMTLLDGP-SYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRY 75
Cdd:COG3398    21 DTRRRIYEYIRENPgIHFREIVRDLGLNRGTLRYHLRRLEREGKITSEKDGGRTRY 76
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 25-79 3.77e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 36.43  E-value: 3.77e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1084273828  25 RILMTLLD--GPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRKTRYEIAD 79
Cdd:COG2512    19 RVLELLREngGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKERVGRENVVELPE 75
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
16-72 5.38e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 37.60  E-value: 5.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1084273828  16 RAMADPTRSRILMTLL-DGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVVAEPEGRK 72
Cdd:COG2345     8 AALADPTRRRILELLKrAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETERRG 65
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
7-79 4.55e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 34.91  E-value: 4.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084273828   7 RLDVMNRLGRAMA----DPTRSRILMTLL--DGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIV--VAEPEGRKTRYEIA 78
Cdd:COG1510     9 KERFIEAFGEMGErwglPRSAGRIYALLYlsDEPLTADELAEELGVSKSSVSTALRELEDWGLVrrVRKPGDRKDYFRAE 88


                  .
gi 1084273828  79 D 79
Cdd:COG1510    89 K 89
COG4742 COG4742
Predicted transcriptional regulator, contains HTH domain [Transcription];
21-65 6.12e-03

Predicted transcriptional regulator, contains HTH domain [Transcription];


Pssm-ID: 443776 [Multi-domain]  Cd Length: 267  Bit Score: 34.87  E-value: 6.12e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1084273828  21 PTRSRILMTLLDGPSYPAVLSRDLDLTRSNVSNHLTCLRDCGIVV 65
Cdd:COG4742    16 EKRKNILLLLAEGPKTRSELAESLDVSRSTILRQLKELEERGLIE 60
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
40-83 6.77e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 34.89  E-value: 6.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1084273828  40 LSRDLDLTRSNVSNHLTCLRDCGIVVAE---PEGRKTRYEIADPHLA 83
Cdd:COG1672   264 IASALGISSSSLSRYLKNLIDLGIIEKEvpvEKSKKGRYRIADPFLR 310
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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