|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-786 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1097.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQADTELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELvQIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVGEEPL-QIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 81 APNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDgVNGLHILPQDAPVGANIREYLDLDDTVFT 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDD-HDGIIELPEDAPVGTDAREYLGLDDTVIE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 161 LKITPNRADCLSIKGIAREVSALTGCAFKQPAIHAAPITGSRKQPVQIDAPADCGRFISRVIENVNARAVTPDWMKQRLE 240
Cdd:PRK00629 159 ISLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 241 RSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAGLMGG 320
Cdd:PRK00629 239 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 321 AASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGEMVEAQGELP 400
Cdd:PRK00629 319 EDSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGVVDVYPLP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 401 EAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPE-KTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPDDYTS 479
Cdd:PRK00629 399 KEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTeVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPPV 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 480 GRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANANPIRLQNPLAAQYAVMRSTLIGGLVEILQNNL 559
Cdd:PRK00629 479 AALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYNL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 560 NRKQNRVRVFEIARVFSKGSDGRfVQNERIGGLWYGAAMPEQWGEKtRNADFYDIKADVENLLKNKAVEFVK----TEHP 635
Cdd:PRK00629 559 NRGNKDVALFEIGRVFLPDGDLP-REPEHLAGVLTGNRVEESWGGK-RPVDFFDLKGDVEALLEALGLPEVEfvaeFEAA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 636 ALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLE--REKTRYQAVSKFQPVRRDLAFVAPEVTTF 713
Cdd:PRK00629 637 ALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLEaaRKLPKYKPISKFPAVRRDLALVVDEDVPA 716
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092565674 714 EQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAAET-VGAHLR 786
Cdd:PRK00629 717 ADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEkFGAELR 790
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-786 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1057.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQADTELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 81 APNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDGvNGLHILPQDAPVGANIREYLDLDDTVFT 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDH-DGIIVLPPDAPVGGDAREYLGLDDTVLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 161 LKITPNRADCLSIKGIAREVSALTGCAFKQPAIHA-APITGSRKQPVQIDAPADCGRFISRVIENVNArAVTPDWMKQRL 239
Cdd:COG0072 160 IDLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLWMQERL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 240 ERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAGLMG 319
Cdd:COG0072 239 RAAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 320 GAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGE-MVEAQGE 398
Cdd:COG0072 319 GEDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVYPE 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 399 LPEAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPDDYT 478
Cdd:COG0072 399 PPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTLP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 479 SGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANANPIRLQNPLAAQYAVMRSTLIGGLVEILQNN 558
Cdd:COG0072 479 RAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAYN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 559 LNRKQNRVRVFEIARVFSKGSDGRFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLL---KNKAVEFVKTEHP 635
Cdd:COG0072 559 LNRGQKDVRLFEIGRVFLPDEGEEPREPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLaalGVPKLEFEAAEHP 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 636 ALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLE--REKTRYQAVSKFQPVRRDLAFVAPEVTTF 713
Cdd:COG0072 639 ALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALLElaRKVPKYKPISKFPAVRRDLALVVDEDVPA 718
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092565674 714 EQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAAET-VGAHLR 786
Cdd:COG0072 719 ADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKkFGAELR 792
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-786 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 821.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQAD-TELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPlSEIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 80 GAPNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDGvNGLHILPQDAPVGANIREYLDLDDTVF 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKS-DGIIVLDEDAPLGTDIAEYLGLDDDII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 160 TLKITPNRADCLSIKGIAREVSALTGCAFKQPAIHAAPIT---GSRKqPVQIDAPADCGRFISRVIENVNArAVTPDWMK 236
Cdd:TIGR00472 160 EVSITPNRGDCLSILGIARELAALFDLNLETPVPFEPETTetiDEGF-KIEIEDPEVCPFYLGRVIKGVKV-KPSPLWLK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 237 QRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAG 316
Cdd:TIGR00472 238 ERLRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 317 LMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGEMVEAQ 396
Cdd:TIGR00472 318 VMGGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVVSDN 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 397 G-ELPEAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPD 475
Cdd:TIGR00472 398 YkEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPA 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 476 DYTSGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANA--NPIRLQNPLAAQYAVMRSTLIGGLVE 553
Cdd:TIGR00472 478 EPLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPEKAEKFNFPKleNLVEIKNPLSNERSVLRTSLLPSLLE 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 554 ILQNNLNRKQNRVRVFEIARVFSKGSDgRFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLK----NKAVEF 629
Cdd:TIGR00472 558 VLAYNQNRKNKDVKIFEIGKVFAKDGE-AVKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLEllglSDDVYF 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 630 VKT-EHPALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLEREK--TRYQAVSKFQPVRRDLAFV 706
Cdd:TIGR00472 637 KNTaENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLESLKkvPKYRPISKFPAVTRDISFL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 707 APE-VTTFEQLQAALcGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAA-ETVGAH 784
Cdd:TIGR00472 717 VPKdVPANEIIKLIK-KSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALkEKLGAE 795
|
..
gi 1092565674 785 LR 786
Cdd:TIGR00472 796 LR 797
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
214-386 |
6.85e-88 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 274.81 E-value: 6.85e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 214 CGRFISRVIENVNARAVTPDWMKQRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNE 293
Cdd:pfam03483 2 CPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLDG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 294 KTVSLSENTLVVADEKGALSLAGLMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADA 373
Cdd:pfam03483 82 KERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEAA 161
|
170
....*....|...
gi 1092565674 374 IERATELVLQICG 386
Cdd:pfam03483 162 LDRATALLLELCG 174
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
214-386 |
1.63e-69 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 225.99 E-value: 1.63e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 214 CGRFISRVIENVNARAVTPDWMKQRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGS-LHIRRAREGETLECLN 292
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 293 EKTVSLSENTLVVADEKGALSLAGLMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQAD 372
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 1092565674 373 AIERATELVLQICG 386
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
489-682 |
7.42e-65 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 214.43 E-value: 7.42e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 489 ETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANA-NPIRLQNPLAAQYAVMRSTLIGGLVEILQNNLNRKQNRVR 567
Cdd:cd00769 1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEEAELFDGGLdEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 568 VFEIARVFSKGSDGrFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLK--NKAVEFVKTEHPA--LHPGRAA 643
Cdd:cd00769 81 LFEIGRVFLKDEDG-PEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRalGIIVEFELEELDAdlFHPGRSA 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 1092565674 644 NIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAV 682
Cdd:cd00769 160 KIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| pheT |
PRK00629 |
phenylalanyl-tRNA synthetase subunit beta; Reviewed |
1-786 |
0e+00 |
|
phenylalanyl-tRNA synthetase subunit beta; Reviewed
Pssm-ID: 234804 [Multi-domain] Cd Length: 791 Bit Score: 1097.14 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQADTELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELvQIVCG 80
Cdd:PRK00629 1 MKFSLSWLKEYVNPDISSEELAEALTMIGLEVEGVEDVAAGLSGVVVGKVLECEKHPNADKLRVCQVDVGEEPL-QIVCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 81 APNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDgVNGLHILPQDAPVGANIREYLDLDDTVFT 160
Cdd:PRK00629 80 APNVRAGDKVPVALPGAVLPGGFKIKKAKLRGVESEGMLCSASELGLSDD-HDGIIELPEDAPVGTDAREYLGLDDTVIE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 161 LKITPNRADCLSIKGIAREVSALTGCAFKQPAIHAAPITGSRKQPVQIDAPADCGRFISRVIENVNARAVTPDWMKQRLE 240
Cdd:PRK00629 159 ISLTPNRADCLSVRGIARELAALLGLPLKLPEIEPVPATIDDKLPVEIEDPDLCPRYAGRVIKGVKNIAPSPLWLQERLR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 241 RSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAGLMGG 320
Cdd:PRK00629 239 AAGIRPINNVVDITNYVMLELGQPLHAFDLDKIGGGIVVRRAKEGEKLTTLDGKERTLDPEDLVIADDKKPLALAGVMGG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 321 AASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGEMVEAQGELP 400
Cdd:PRK00629 319 EDSEVTENTTNVLLESAYFDPVSIRKTARRLGLRTDASYRFERGVDPALTLLALERATALILELGGGEVVEGVVDVYPLP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 401 EAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPE-KTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPDDYTS 479
Cdd:PRK00629 399 KEPTITLRLERINRLLGTEISDEEIVDILKRLGFEVTeVDGDGLTVTVPSWRFDIEIEEDLVEEVARIYGYDNIPSTPPV 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 480 GRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANANPIRLQNPLAAQYAVMRSTLIGGLVEILQNNL 559
Cdd:PRK00629 479 AALTMGGLTEAQRLLRRLRRALAALGYQEVITYSFVSPEDAKLFGLNPEPLLLLNPISEELSVMRTSLLPGLLEAVAYNL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 560 NRKQNRVRVFEIARVFSKGSDGRfVQNERIGGLWYGAAMPEQWGEKtRNADFYDIKADVENLLKNKAVEFVK----TEHP 635
Cdd:PRK00629 559 NRGNKDVALFEIGRVFLPDGDLP-REPEHLAGVLTGNRVEESWGGK-RPVDFFDLKGDVEALLEALGLPEVEfvaeFEAA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 636 ALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLE--REKTRYQAVSKFQPVRRDLAFVAPEVTTF 713
Cdd:PRK00629 637 ALHPGRSAEIYLDGKVIGFIGELHPKVLKKLDLPGRTYVFELDLDALLEaaRKLPKYKPISKFPAVRRDLALVVDEDVPA 716
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092565674 714 EQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAAET-VGAHLR 786
Cdd:PRK00629 717 ADILKAIKKAGGKLLESVELFDVYEGKGIGEGKKSLAFRLTFQDPDRTLTDEEINAAMDKIVAALEEkFGAELR 790
|
|
| PheT |
COG0072 |
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; ... |
1-786 |
0e+00 |
|
Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Phenylalanyl-tRNA synthetase beta subunit is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439842 [Multi-domain] Cd Length: 793 Bit Score: 1057.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQADTELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCG 80
Cdd:COG0072 1 MKLSLLWLLLLVEEAALLEELLLLLTGEGLEEEEVEGAAAVVVGVVVVVVVVEEPHPDADDLVVVVVDVGGGEVLVVVCG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 81 APNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDGvNGLHILPQDAPVGANIREYLDLDDTVFT 160
Cdd:COG0072 81 AANVAVGVVVVAAPGGAVLPGGFKIKKAKIRGVESSGMLCSEEELGLGEDH-DGIIVLPPDAPVGGDAREYLGLDDTVLE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 161 LKITPNRADCLSIKGIAREVSALTGCAFKQPAIHA-APITGSRKQPVQIDAPADCGRFISRVIENVNArAVTPDWMKQRL 239
Cdd:COG0072 160 IDLTPNRADCLSVRGVARELAALLGAPLKLPAIEPeVPPAIDDPIPVEIEDPEACPRYAGRVIRGVKV-GPSPLWMQERL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 240 ERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAGLMG 319
Cdd:COG0072 239 RAAGIRPINNVVDITNYVMLELGQPLHAFDLDKLKGGIVVRRAREGEKLTTLDGKERTLDPDDLVIADDEGPLALAGVMG 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 320 GAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGE-MVEAQGE 398
Cdd:COG0072 319 GEDSEVTEETTDVLLESAYFDPVSIRRTARRLGLHSDASYRFERGVDPALTVAALERATQLILEIAGGEVGPgIVDVYPE 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 399 LPEAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPDDYT 478
Cdd:COG0072 399 PPEPKTITLRLARINRLLGVEIPAEEIEEILERLGFEVEEDGDGLTVTVPSWRFDIEIEADLIEEVARIYGYDNIPSTLP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 479 SGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANANPIRLQNPLAAQYAVMRSTLIGGLVEILQNN 558
Cdd:COG0072 479 RAPLAGGGLTEAQRLRRRVRRALAARGYQEVITYSFVSPEDADLFGLRREAVRLANPISEDLSVMRTSLLPGLLEAAAYN 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 559 LNRKQNRVRVFEIARVFSKGSDGRFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLL---KNKAVEFVKTEHP 635
Cdd:COG0072 559 LNRGQKDVRLFEIGRVFLPDEGEEPREPLHLAGVLTGNREPESWGGKARPVDFFDLKGDVEALLaalGVPKLEFEAAEHP 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 636 ALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLE--REKTRYQAVSKFQPVRRDLAFVAPEVTTF 713
Cdd:COG0072 639 ALHPGRSAEILLGGKVIGFIGELHPKVLKALDLPGPVYVFELDLDALLElaRKVPKYKPISKFPAVRRDLALVVDEDVPA 718
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1092565674 714 EQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAAET-VGAHLR 786
Cdd:COG0072 719 ADVLDAIRKAAGKLLEDVRLFDVYEGKGVPEGKKSLAFSLTLQDPDRTLTDEEIDAAMDKIVAALEKkFGAELR 792
|
|
| pheT_bact |
TIGR00472 |
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of ... |
1-786 |
0e+00 |
|
phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from Bacteria other than spirochetes, as well as a chloroplast-encoded form from Porphyra purpurea. The chloroplast-derived sequence is considerably shorter at the amino end. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273097 [Multi-domain] Cd Length: 797 Bit Score: 821.54 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQAD-TELSADKLEHLLTMSGLEVEEAETAAPVFTGVVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVC 79
Cdd:TIGR00472 1 MKISLKWLREYVPlSEIDNEEIAEALTSIGLEVEAVIPFSKPLKGVVVGKVLEVEPHPNADKLKVCKVDIGEKEMLQIVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 80 GAPNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDGvNGLHILPQDAPVGANIREYLDLDDTVF 159
Cdd:TIGR00472 81 GAPNVEAGKKVAVALPGAKLPNGLKIKKSKLRGVESEGMLCSESELGLDEKS-DGIIVLDEDAPLGTDIAEYLGLDDDII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 160 TLKITPNRADCLSIKGIAREVSALTGCAFKQPAIHAAPIT---GSRKqPVQIDAPADCGRFISRVIENVNArAVTPDWMK 236
Cdd:TIGR00472 160 EVSITPNRGDCLSILGIARELAALFDLNLETPVPFEPETTetiDEGF-KIEIEDPEVCPFYLGRVIKGVKV-KPSPLWLK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 237 QRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAG 316
Cdd:TIGR00472 238 ERLRRSGIRPINNIVDITNYVMLELGQPLHAFDADKIEGNIVVRSAKEGESFTTLDGKERELKKGDLVIADDKKPLAIAG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 317 LMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGEMVEAQ 396
Cdd:TIGR00472 318 VMGGKESGVTDTTTNIFLESAYFNPESIRKTARRLGISTDSSYRFERGVDPELTELALDRALNLILEIFGGEVISVVSDN 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 397 G-ELPEAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPD 475
Cdd:TIGR00472 398 YkEKAKEKKISLRIKKLNKILGIELSDEEVRDILKRLGFKVEKQKDGWEVTVPSYRHDIEIEEDLIEEIARIYGYDNIPA 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 476 DYTSGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANA--NPIRLQNPLAAQYAVMRSTLIGGLVE 553
Cdd:TIGR00472 478 EPLSVSSKLNKNNENYLLLRKLRTLLVGLGLNEVITYSFVDPEKAEKFNFPKleNLVEIKNPLSNERSVLRTSLLPSLLE 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 554 ILQNNLNRKQNRVRVFEIARVFSKGSDgRFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLK----NKAVEF 629
Cdd:TIGR00472 558 VLAYNQNRKNKDVKIFEIGKVFAKDGE-AVKEQLRLAILISGEKNPSSWNHKEEKVDFYDLKGDVESLLEllglSDDVYF 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 630 VKT-EHPALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLEREK--TRYQAVSKFQPVRRDLAFV 706
Cdd:TIGR00472 637 KNTaENEELHPGQSATIYLKGKKIGFIGELHPEIAKKYDLKEPTFVFELDLDRLLESLKkvPKYRPISKFPAVTRDISFL 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 707 APE-VTTFEQLQAALcGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHKLIAAA-ETVGAH 784
Cdd:TIGR00472 717 VPKdVPANEIIKLIK-KSGLELLEEVELFDVYQGKNIGEGKKSLALRLVLRDKERTLTDEEINKIVEKVLNALkEKLGAE 795
|
..
gi 1092565674 785 LR 786
Cdd:TIGR00472 796 LR 797
|
|
| EMAP |
COG0073 |
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis]; |
1-768 |
1.14e-148 |
|
tRNA-binding EMAP/Myf domain [Translation, ribosomal structure and biogenesis];
Pssm-ID: 439843 [Multi-domain] Cd Length: 773 Bit Score: 454.31 E-value: 1.14e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 1 MQFSYSWLKTQADTELSADKLEHLLTMSGLEVEEAETAAPvFTGVVIAEVKSVEKHPDADRLNVTQVDAGTgELVQIVCG 80
Cdd:COG0073 1 MKVSLSWLKEYVDLDLSPEELAEKLTMAGIEVEDFEKVGG-LDGLRVGKVLEAEPHPNADKLLVLQVDVGE-ETRQIVCG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 81 APNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDELGLPDDgVNGLHILPQDAPVGaNIREYLDLDDTVFT 160
Cdd:COG0073 79 APNVYAGDKVPEALVGAQVPGVVNLKPRKIRGVESEGMLCSAEELGLGED-HDGILELPEDAPPG-DDAEYLLLLDDVII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 161 LKITPNRADCLSIKGIAREVSALTGCAFKQPAIHAAPITGSRKQPVQIDAPADCGRFISRVIENVNARAVTPDWMKQRLE 240
Cdd:COG0073 157 EILTTPNRDDLLSVGGAAREAAALGGLLLKPPAPPVVEGTDDAVLVVVVDDDACDRYYGRVVRGVVNVVVPPPPWLRRLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 241 RSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNEKTVSLSENTLVVADEKGALSLAGLMGG 320
Cdd:COG0073 237 RRGGRRRIINVVDINNVVLLLLGQPHHAFDDDDLGGGIVVRRRRAEELLLLLLGDTTLLLDDLLLIDDDDDALAAAGGGG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 321 AASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELVLQICGGAAGEMVE---AQG 397
Cdd:COG0073 317 GGGGSSGSTTTTTLLLAAAAFFAAAGRRRRRRRLSSRSSRRRRREDDDDPRVAAAAAAAALLLIILGGGGGVAGgvvDEG 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 398 ELPEAQQVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGYENIPDDY 477
Cdd:COG0073 397 LPPPPPRIIRLRRRRRLLLLGIDIDEEELLLLLLLLGFEVEGEGESVVVPPPRRRDDVIEEDEEEEEARRYYYYDLPPPP 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 478 TSGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANANPIRLQNPLAAQYAVMRSTLIGGLVEILQN 557
Cdd:COG0073 477 PPAPPAVPEPPAARRRLRRRRRLLLLLGLEEAVTYSSFSELLLALLLLFEAALLLLLPPSSLSSSLLLSLLLLLLLLVLL 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 558 NLNRKQNRVRVFEIARVFSKGSDGRFVQ------NERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLKNKAVEFVK 631
Cdd:COG0073 557 LLRRRNRNRRLFEGGEVFFGFEGGGLELllaeleAGGALLLGGGGGAALGLAADDADDLAGVLLLLALLLGLLALLALAA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 632 TEHPALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVLEREKTRYQAVSKFQPVRRDLAFVAPEVT 711
Cdd:COG0073 637 AAPAAAAPGAGGAGGLLLGGGGGLGGLLPVLLKLLLLLLLALLFEVLLDELLLPAAVLLALPLVARPLLRAIVVDVAAAV 716
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 1092565674 712 TFEQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVE 768
Cdd:COG0073 717 AAALAAVAAALALVVALLAVVLLVVVVDVGVGKVLKKLLLSLDLEVTLLDLEELELT 773
|
|
| syfB |
CHL00192 |
phenylalanyl-tRNA synthetase beta chain; Provisional |
155-775 |
6.34e-88 |
|
phenylalanyl-tRNA synthetase beta chain; Provisional
Pssm-ID: 214391 [Multi-domain] Cd Length: 704 Bit Score: 292.38 E-value: 6.34e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 155 DDTVFTLKITPNRADCLSIKGIAREVSALTGcafKQPAIHAA--PITGSRKQ----PVQIDAPADCGRFISRVIENVNAR 228
Cdd:CHL00192 45 SDIILDISSTANRSDVLSIQGLSREISALFN---SDPIKLKYynPSISWFDKlknlISNDSSKLNCSMFIAVIIENIEIK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 229 AVtPDWMKQRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSG-----SLHIRRAREGETLE--CLNEKTVSLSEN 301
Cdd:CHL00192 122 DS-PKWLQNRLSSSGFKSLNNLTDIQNYIMLETGQPIEIYDLDKIYSknttsSLALSSKFALQKSSfiASNSKNIELENN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 302 TLVVADEKGALSLAGLMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADAIERATELV 381
Cdd:CHL00192 201 ILVVQANNVIISIAGIISNEEIICDKNTKSILIEASIFDAAVIRKSSRKLGLRTDRSIRYEKSLKNDNLLEAYYRLVSLL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 382 -LQICGGAAGEMVEAQGELPEAQQVELRLGRLKTVLG--------VDIPAEQVETILQHLGLQP--EKTAEGFRVTAPSF 450
Cdd:CHL00192 281 rILNPKLKCKFHFIYKKIKNSSRRIKLSYKKIKDILGpikintntRYLSPKEITNALKRLNFKItyDSLKLNWEVLIPSY 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 451 R-FDIEIEADLIEEIGRVYGYEN----IPDDYTSGRLKMLAlPETRRPRFAVYNemaaRGYREVVSYAFVDEQWEHDfaa 525
Cdd:CHL00192 361 RkDDIVREIDVIEEIARIYGFNNflskLPNIKFIGRLDIDY-NTRDKIRSYLRN----LGLTELIHYSLVKQESFSK--- 432
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 526 naNPIRLQNPLAAQYAVMRSTLIGGLVEILQNNLNRKQNRVRVFEIARVFSKGSDGRFVQNERIGGLWYGAAMPEQWGEK 605
Cdd:CHL00192 433 --NEIKLKNPLIKDYSTLRSSLLPGLIEAVQENLKQGNSTLEGFEIGHVFNLDSSSIIEETELAGGIFGGIDIRSSWSEK 510
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 606 TRNADFYDIKADVENLLK--NKAVEFVKTE--------HPALHpgrAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVF 675
Cdd:CHL00192 511 AQSLNWFEAKGIIENFFQklNLPIYWKKYSdldekinfHPYCT---SEIFLSNGQKIGIFGQLHPLLANKLNLNTEIYLF 587
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 676 EIDM----AAVLEREKTRYQAVSKFQPVRRDLAFVAPEVTTFEQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAV 751
Cdd:CHL00192 588 EINLdilqYSIQQNNLISYQPYSSYPKIIRDLSFIIKKSISISKIKELIYQNGDNLLESITLFDYYKGKSIPNGHTSLGL 667
|
650 660
....*....|....*....|....
gi 1092565674 752 KVILQDAERTLTDDTVEEIVHKLI 775
Cdd:CHL00192 668 RLTFQSENKTLTNEEIDRIQQNLQ 691
|
|
| B3_4 |
pfam03483 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
214-386 |
6.85e-88 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 427327 [Multi-domain] Cd Length: 174 Bit Score: 274.81 E-value: 6.85e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 214 CGRFISRVIENVNARAVTPDWMKQRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNE 293
Cdd:pfam03483 2 CPRYFGRVIRGVKKNRPSPEWLQRRLRRAGIRPINNVVDITNYVMLELGQPLHAFDLDKIAGDIVVRLAKGGEKFTTLDG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 294 KTVSLSENTLVVADEKGALSLAGLMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQADA 373
Cdd:pfam03483 82 KERELDPGDLVIADDDGPVALAGIMGGEESEVTEDTTNIFLESAGFDPVAIRKTARRLGLRTDASYRFERGVDPELVEAA 161
|
170
....*....|...
gi 1092565674 374 IERATELVLQICG 386
Cdd:pfam03483 162 LDRATALLLELCG 174
|
|
| tRNA_synthFbeta |
pfam17759 |
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic ... |
473-679 |
3.68e-77 |
|
Phenylalanyl tRNA synthetase beta chain CLM domain; This domain corresponds to the catalytic like domain (CLM) in the beta chain of phe tRNA synthetase.
Pssm-ID: 465487 [Multi-domain] Cd Length: 214 Bit Score: 247.85 E-value: 3.68e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 473 IPDDYTSGRLKMLALPETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAA---NANPIRLQNPLAAQYAVMRSTLIG 549
Cdd:pfam17759 1 IPSTLPKGPTTGGGLTPEQKLRRRVRDLLAAAGFTEVITYSFTSPKDLDKLLEddpRRKAVKLANPLSEELSVMRTSLLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 550 GLVEILQNNLNRKQNRVRVFEIARVFSK-GSDGRFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLKN---K 625
Cdd:pfam17759 81 GLLETLAYNLNRGNPDVRLFEIGRVFLPdELEELPREPRRLAGLLTGKRLPESWQGKARPVDFYDLKGIVEALLAAlgiD 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1092565674 626 AVEFVKTEHPALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDM 679
Cdd:pfam17759 161 DYEFEAADHPALHPGRSAEILVGGKVIGFIGELHPEVAKNFDLPQPVYVFELDL 214
|
|
| B3_4 |
smart00873 |
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ... |
214-386 |
1.63e-69 |
|
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.
Pssm-ID: 214876 [Multi-domain] Cd Length: 174 Bit Score: 225.99 E-value: 1.63e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 214 CGRFISRVIENVNARAVTPDWMKQRLERSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGS-LHIRRAREGETLECLN 292
Cdd:smart00873 1 CPRYLGRVIRGVKNTRPSPEWLQERLHRAGIRPINNVVDITNYVSLETGQPLHAFDLDKIKGKdIPLRRAKEGEKFETLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 293 EKTVSLSENTLVVADEKGALSLAGLMGGAASAVSDDTQNIVLEAAWFAPEIIAGKSRQYGFGSDSSFRFERGVDYRLQAD 372
Cdd:smart00873 81 GKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTIRITARTLNLFTDASGRFERGVDPELVEL 160
|
170
....*....|....
gi 1092565674 373 AIERATELVLQICG 386
Cdd:smart00873 161 ALDRAAALLLEICG 174
|
|
| PheRS_beta_core |
cd00769 |
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II ... |
489-682 |
7.42e-65 |
|
Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. PheRS is an alpha-2/ beta-2 tetramer. While the alpha chain contains a catalytic core domain, the beta chain has a non-catalytic core domain.
Pssm-ID: 238392 [Multi-domain] Cd Length: 198 Bit Score: 214.43 E-value: 7.42e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 489 ETRRPRFAVYNEMAARGYREVVSYAFVDEQWEHDFAANA-NPIRLQNPLAAQYAVMRSTLIGGLVEILQNNLNRKQNRVR 567
Cdd:cd00769 1 PLQKLERKLRRLLAGLGFQEVITYSLTSPEEAELFDGGLdEAVELSNPLSEEYSVLRTSLLPGLLDALARNLNRKNKPLR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 568 VFEIARVFSKGSDGrFVQNERIGGLWYGAAMPEQWGEKTRNADFYDIKADVENLLK--NKAVEFVKTEHPA--LHPGRAA 643
Cdd:cd00769 81 LFEIGRVFLKDEDG-PEEEEHLAALLSGNREPESWQGKGRPVDFYDAKGILEALLRalGIIVEFELEELDAdlFHPGRSA 159
|
170 180 190
....*....|....*....|....*....|....*....
gi 1092565674 644 NIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAV 682
Cdd:cd00769 160 KIYVNGEVIGFIGELHPEVLKEFDLKEPVYAFELDLDAL 198
|
|
| tRNA_bind_bactPheRS |
cd02796 |
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. ... |
45-148 |
5.20e-51 |
|
tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate the 2'OH of the terminal ribose of tRNA they belong functionally to class 1 aaRSs. This domain has general tRNA binding properties and is believed to direct tRNAphe to the active site of the enzyme.
Pssm-ID: 239196 [Multi-domain] Cd Length: 103 Bit Score: 173.08 E-value: 5.20e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 45 VVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCGAPNVKAGIKVPCSLPGAVLPGNFKIKPTKMRGVVSNGMLCSTDE 124
Cdd:cd02796 1 VVVGKVLEVEPHPNADKLNVCKVDIGENKPLQIVCGAPNVRAGDKVVVALPGAVLPGGLKIKKRKLRGVESEGMLCSAKE 80
|
90 100
....*....|....*....|....
gi 1092565674 125 LGLPDDgVNGLHILPQDAPVGANI 148
Cdd:cd02796 81 LGLGED-SDGIIELPEDAPVGTDI 103
|
|
| tRNA_bindingDomain |
cd02153 |
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in ... |
45-148 |
8.77e-32 |
|
The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-tRNA synthetase(hTyrRS), Saccharomyces cerevisiae Arc1p, Thermus thermophilus CsaA, Aquifex aeolicus Trbp111, human p43 and human EMAP-II. PheRS, MetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. The molecular chaperones Trbp111 and CsaA also contain this domain. CsaA has export related activities; Trbp111 is structure-specific recognizing the L-shape of the tRNA fold. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. An EMAP-II-like cytokine is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain. For homodimeric members of this group which include CsaA, Trbp111 and Escherichia coli MetRS this domain acts as a dimerization domain.
Pssm-ID: 239066 [Multi-domain] Cd Length: 99 Bit Score: 119.16 E-value: 8.77e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 45 VVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCGAPNV-----KAGIKVPCSLPgavlpgnfkIKPTKMRGVVSNGML 119
Cdd:cd02153 1 LRVGKIVEAEPHPNADKLYVLKVDIGEEKPRQIVSGAANVyppeeLVGKKVVVAVN---------LKPKKLRGVESEGML 71
|
90 100
....*....|....*....|....*....
gi 1092565674 120 CSTDELGLPDDGVnGLHILPQDAPVGANI 148
Cdd:cd02153 72 LSAEELGLEEGSV-GILELPEDAPVGDRI 99
|
|
| FDX-ACB |
smart00896 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
694-786 |
1.24e-28 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold, consisting of an alpha+beta sandwich with anti-parallel beta-sheets (beta-alpha-beta x2).
Pssm-ID: 214893 [Multi-domain] Cd Length: 93 Bit Score: 109.82 E-value: 1.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 694 SKFQPVRRDLAFVAPEVTTFEQLQAALCGVKSDLIQEITLFDVYRGvGLPENMKSMAVKVILQDAERTLTDDTVEEIVHK 773
Cdd:smart00896 1 SKFPAVRRDLAFVVDEDVPAAELLDAIREAGGDLLEDVRLFDVYEG-GIPEGKKSLAYRLTYQSPDRTLTDEEVNAIHDK 79
|
90
....*....|....
gi 1092565674 774 LIAAAET-VGAHLR 786
Cdd:smart00896 80 IVAALEKkFGAELR 93
|
|
| FDX-ACB |
pfam03147 |
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some ... |
694-786 |
2.58e-26 |
|
Ferredoxin-fold anticodon binding domain; This is the anticodon binding domain found in some phenylalanyl tRNA synthetases. The domain has a ferredoxin fold.
Pssm-ID: 460826 [Multi-domain] Cd Length: 94 Bit Score: 103.33 E-value: 2.58e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 694 SKFQPVRRDLAFVAPEVTTFEQLQAALCGVKSDLIQEITLFDVYRGVGLPENMKSMAVKVILQDAERTLTDDTVEEIVHK 773
Cdd:pfam03147 1 SKYPAVRRDLAFVVDEDVPAADILKAIREAGGELLESVELFDVYRGEKIPEGKKSLAFRLTFQSPERTLTDEEVNAIIEK 80
|
90
....*....|....
gi 1092565674 774 LIAAAET-VGAHLR 786
Cdd:pfam03147 81 IVEALEKkFGAELR 94
|
|
| B5 |
smart00874 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
405-470 |
7.63e-25 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 197942 [Multi-domain] Cd Length: 68 Bit Score: 97.95 E-value: 7.63e-25
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092565674 405 VELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGY 470
Cdd:smart00874 3 ITLRLERINRLLGLEILAEEIEEILKRLGFEVEVSGDTLEVTVPSYRFDILIEADLIEEVARIYGY 68
|
|
| tRNA_bind |
pfam01588 |
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, ... |
45-147 |
4.66e-24 |
|
Putative tRNA binding domain; This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1), human tyrosyl-tRNA synthetase, and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases. In human tyrosyl-tRNA synthetase this domain may direct tRNA to the active site of the enzyme. This domain may perform a common function in tRNA aminoacylation.
Pssm-ID: 396251 [Multi-domain] Cd Length: 96 Bit Score: 96.93 E-value: 4.66e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 45 VVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCGAPNVKAGIKVPCSLpGAVLPgnfKIKPTKMRGVVSNGMLCSTDE 124
Cdd:pfam01588 1 LRVGKVVEAERHPNADKLLVCKVDVGEEEPRQIVSGAVNVYPPEELVGRL-VVVVA---NLKPAKLRGVESEGMILSAEE 76
|
90 100
....*....|....*....|...
gi 1092565674 125 LglpDDGVNGLHILPQDAPVGAN 147
Cdd:pfam01588 77 L---DGGSVGLLEPPADVPPGTK 96
|
|
| B5 |
pfam03484 |
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits. |
405-470 |
5.85e-24 |
|
tRNA synthetase B5 domain; This domain is found in phenylalanine-tRNA synthetase beta subunits.
Pssm-ID: 460942 [Multi-domain] Cd Length: 67 Bit Score: 95.54 E-value: 5.85e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1092565674 405 VELRLGRLKTVLGVDIPAEQVETILQHLGLQ-PEKTAEGFRVTAPSFRFDIEIEADLIEEIGRVYGY 470
Cdd:pfam03484 1 ITLRLDRINRLLGIDLSAEEIVEILERLGFEvEEEDGDTLTVTVPSYRPDILHEADLIEEVARIYGY 67
|
|
| PLN02265 |
PLN02265 |
probable phenylalanyl-tRNA synthetase beta chain |
404-683 |
4.94e-20 |
|
probable phenylalanyl-tRNA synthetase beta chain
Pssm-ID: 215149 [Multi-domain] Cd Length: 597 Bit Score: 94.75 E-value: 4.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 404 QVELRLGRLKTVLGVDIPAEQVETILQHLGLQPEKTAEG---FRVTAPSFRFDIEIEADLIEEIGRVYGYENI----PDD 476
Cdd:PLN02265 311 TMEVDLSYINSSIGVSLDAEEVASLLNKMQLQAEQSSDDgctIRVSVPPTRSDILHPCDVAEDVAIAYGYNNIpkrkPKS 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 477 YTSGrlKMLALPETRRprfAVYNEMAARGYREVVSYAFVDEqwEHDFAANANP------IRLQNPLAAQYAVMRSTLIGG 550
Cdd:PLN02265 391 MTVG--KQQPLNQFSD---LLRAEVAMAGFTEVLTWILCSH--KENFAMLNREddgnsaVIIGNPRSADFEVVRTSLLPG 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 551 LVEILQNNLNRKQNrVRVFEIARV--FSKGSDGRFVQNERIGGLWYGAampeqwgektrNADFYDIKADVENLLKNKAVE 628
Cdd:PLN02265 464 LLKTLGHNKDAPKP-IKLFEVSDVvlLDESKDVGARNSRRLAALYCGT-----------TSGFEVIHGLVDRIMEVLGIP 531
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092565674 629 FVK-----------TEHPALHPGRAANIVSDGQVIGFVGELHPKWLQKYDLPQAPLVFEIDMAAVL 683
Cdd:PLN02265 532 FVEigdnngyyvepSNEPEYFPGRQASIIYKGKHVGTFGIVHPEVLNNFDIPDPCSFLELDLEPLL 597
|
|
| B3/B4 |
COG3382 |
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only] ... |
241-391 |
2.97e-12 |
|
B3/B4 domain (DNA/RNA-binding domain of Phe-tRNA-synthetase) [General function prediction only];
Pssm-ID: 442609 [Multi-domain] Cd Length: 233 Bit Score: 67.19 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 241 RSGIRSISALVDIGNYVMLEIGQPMHVFDADKLSGSLHIRRAREGETLECLNE-KTVSLSENTLVVADEKGALslaglmG 319
Cdd:COG3382 92 GGGLPRINPLVDLYNAVSLRYLLPIGGYDLDKIEGDLRLRLARGGESFLPIGGdEEEPPEPGEVVYADDEGVF------C 165
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1092565674 320 -------GAASAVSDDTQNIVLeaawfapeIIagksrqYGFGSDSsfrfergVDYRLQadAIERATELVLQICGGAAGE 391
Cdd:COG3382 166 rrwpwrdSERTKVTEETKNALF--------II------EGLPGVS-------AEDLEA--ALDELAELLERYLGGEVVK 221
|
|
| tRNA_bind_EMAP-II_like |
cd02799 |
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of ... |
45-148 |
2.78e-11 |
|
tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae Arc1p, human p43 and EMAP2. CeMetRS and hTyrRS aminoacylate their cognate tRNAs. Arc1p is a transactivator of yeast methionyl-tRNA and glutamyl-tRNA synthetases. This domain has general tRNA binding properties. In a subset of this family this domain has the added capability of a cytokine. For example the p43 component of the Human aminoacyl-tRNA synthetase complex is cleaved to release EMAP-II cytokine. EMAP-II has multiple activities during apoptosis, angiogenesis and inflammation and participates in malignant transformation. A EMAP-II-like cytokine also is released from hTyrRS upon cleavage. The active cytokine heptapeptide locates to this domain.
Pssm-ID: 239198 [Multi-domain] Cd Length: 105 Bit Score: 60.70 E-value: 2.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 45 VVIAEVKSVEKHPDADRLNVTQVDAGTGELVQIVCGAPNVKAGIKVPCSLpgAVLPGNfkIKPTKMRGVVSNGM-LCSTD 123
Cdd:cd02799 8 IRVGKILKVRKHPDADSLYVEEIDLGEEEPRTIVSGLVKFVPLEQMQNRL--VVVLCN--LKPRKMRGVKSQGMvLCASN 83
|
90 100
....*....|....*....|....*
gi 1092565674 124 elglPDDGVNGLHILPQDAPVGANI 148
Cdd:cd02799 84 ----ADHEKVELLEPPEGAKPGERV 104
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
13-149 |
7.81e-11 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 65.59 E-value: 7.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 13 DTELSADKLEHLLTMSGLEVEEAETAAPV--------FTGVVI--AEVKSVEKHPDADRLNVTQVDAGTGELVQIVcgap 82
Cdd:PRK12267 511 DVEEEIAYIKEQMEGSAPKEPEEKEKKPEkpeitiddFDKVELrvAEVLEAEKVEKSDKLLKLQVDLGEEEPRQIV---- 586
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1092565674 83 nvkAGIK---VPCSLPG--AVLPGNfkIKPTKMRGVVSNGMLCSTDelglpDDGVNGLHILPQDAPVGANIR 149
Cdd:PRK12267 587 ---SGIAkfyPPEELVGkkVVVVAN--LKPAKLMGEESQGMILAAE-----DDGKLTLLTVDKEVPNGSKVK 648
|
|
| tRNA_bind_EcMetRS_like |
cd02800 |
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like ... |
47-149 |
4.00e-07 |
|
tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine transfer RNAs (tRNAmet). AaTrbp111 is structure-specific molecular chaperone recognizing the L-shape of the tRNA fold. AaTrbp111 plays a role in nuclear trafficking of tRNAs. The functional unit of EcMetRs and AaTrbp111 is a homodimer, this domain acts as the dimerization domain.
Pssm-ID: 239199 [Multi-domain] Cd Length: 105 Bit Score: 49.04 E-value: 4.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 47 IAEVKSVEKHPDADRLNVTQVDAGtGELVQIVcgapnvkAGIKV---PCSLPG--AVLPGNFKikPTKMRGVVSNGMLCS 121
Cdd:cd02800 13 VGKVLEAERVEGSDKLLKLTVDLG-EEERQIV-------SGIAKfypPEELVGkkVVVVANLK--PRKLRGVESQGMILA 82
|
90 100
....*....|....*....|....*...
gi 1092565674 122 TDelglpDDGVNGLHILPQDAPVGANIR 149
Cdd:cd02800 83 AE-----DGGKLKLLTPDEEVEPGSRVS 105
|
|
| PLN02610 |
PLN02610 |
probable methionyl-tRNA synthetase |
50-145 |
2.72e-06 |
|
probable methionyl-tRNA synthetase
Pssm-ID: 215329 [Multi-domain] Cd Length: 801 Bit Score: 50.93 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 50 VKSVEKHPDADRLNVTQVDAGTGELVQIVCGApnVK-------AGIKVpCSLpgavlpgnFKIKPTKMRGVVSNGM-LCS 121
Cdd:PLN02610 650 IVKAEKHPDADSLYVEEIDVGEGAPRTVVSGL--VKyipleemQNRKV-CVL--------CNLKPAAMRGIKSQAMvLAA 718
|
90 100
....*....|....*....|....
gi 1092565674 122 TDElglpDDGVNGLHILPQDAPVG 145
Cdd:PLN02610 719 SNS----DHTKVELVEPPESAAVG 738
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
47-149 |
2.74e-06 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 50.92 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 47 IAEVKSVEKHPDADRLNVTQVDAGtGELVQIVcgapnvkAGIKV---PCSLPGA--VLPGNFKikPTKMRGVVSNGMLCS 121
Cdd:PRK00133 580 VAKIVEAEKVEGADKLLKLTLDLG-EETRQVF-------SGIKSaydPEELVGKlvVMVANLA--PRKMKFGVSEGMVLA 649
|
90 100 110
....*....|....*....|....*....|
gi 1092565674 122 TDelglPDDGvnGLHIL--PQDAPVGANIR 149
Cdd:PRK00133 650 AG----PGGG--DLFLLepDEGAKPGMRVK 673
|
|
| PLN02788 |
PLN02788 |
phenylalanine-tRNA synthetase |
687-774 |
5.78e-04 |
|
phenylalanine-tRNA synthetase
Pssm-ID: 215422 [Multi-domain] Cd Length: 402 Bit Score: 43.21 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092565674 687 KTRYQAVSKFQPVRRDLAFVAPEVTTFEQLQAALCGVKSDLIQEITLFDVYRGvglPENMK-SMAVKVILQDAERTLTDD 765
Cdd:PLN02788 304 GVKFKPYSKYPPCYKDISFWISDEFTENNLCEVVRGIAGDLVEEVKLIDNFTN---PKKGKtSHCYRIVYRSMERSLTDE 380
|
....*....
gi 1092565674 766 TVEEIVHKL 774
Cdd:PLN02788 381 EINALQDKV 389
|
|
| |
