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Conserved domains on  [gi|1092666999|ref|WP_070601426|]
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MULTISPECIES: YafY family protein [Corynebacterium]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 11457199)

helix-turn-helix (HTH) transcriptional regulator containing DNA-binding HTH and WYL domains, may function in the regulation of DNA damage response and bacterial immunity

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
18-330 2.40e-33

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


:

Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 125.19  E-value: 2.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  18 TQRQVQLLLALADdTGWVSESWISKHVEgysrVSEdsraRYLRADTAALLAAGVPVEvsssSAGDKVKRLRLNRlRWTQH 97
Cdd:COG2378     4 LERLLALLQLLQS-RRGVTAAELAERLE----VSE----RTIYRDIDALRELGVPIE----AERGRGGGYRLRD-GYRLP 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  98 DPEFTEAEASVVFQAAN--AAFGSEELSSTAVAAWRKLASF---AQRSAIAKPDESVVVADAVDMSRVDFSTLLTAMTSp 172
Cdd:COG2378    70 PLMLTEEEALALLLALRllAALGGAPLAEAAASALAKLEAVlpeRLRERLEALAERVGVDPPPEVDPEVLETLREAIRE- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 173 RRTVEMWYSRQYGvDDELRMLEPWGLINLRGRFYVLGFDPQREAARMFRLSRIRDVSDTGTSATQPmPDGDLQQIAEN-- 250
Cdd:COG2378   149 RRRLRIDYRSGRG-EPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPP-PDFDLAEYLAEgf 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 251 -MLHRGGKTYQAVVRIAPNTCADV-----VMKATALGDGRYEL--PAAPVSEIVSTGLSYAPDLIVESPEEARSEIIARL 322
Cdd:COG2378   227 gVFAGGPEPVTVTLRFSPEAARYLrerhpSQEIEELPDGSVRVtlTVADLDELARWLLSFGADVEVLEPEELREAVREEA 306

                  ....*...
gi 1092666999 323 EQVLARHG 330
Cdd:COG2378   307 RRLLARYE 314
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
18-330 2.40e-33

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 125.19  E-value: 2.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  18 TQRQVQLLLALADdTGWVSESWISKHVEgysrVSEdsraRYLRADTAALLAAGVPVEvsssSAGDKVKRLRLNRlRWTQH 97
Cdd:COG2378     4 LERLLALLQLLQS-RRGVTAAELAERLE----VSE----RTIYRDIDALRELGVPIE----AERGRGGGYRLRD-GYRLP 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  98 DPEFTEAEASVVFQAAN--AAFGSEELSSTAVAAWRKLASF---AQRSAIAKPDESVVVADAVDMSRVDFSTLLTAMTSp 172
Cdd:COG2378    70 PLMLTEEEALALLLALRllAALGGAPLAEAAASALAKLEAVlpeRLRERLEALAERVGVDPPPEVDPEVLETLREAIRE- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 173 RRTVEMWYSRQYGvDDELRMLEPWGLINLRGRFYVLGFDPQREAARMFRLSRIRDVSDTGTSATQPmPDGDLQQIAEN-- 250
Cdd:COG2378   149 RRRLRIDYRSGRG-EPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPP-PDFDLAEYLAEgf 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 251 -MLHRGGKTYQAVVRIAPNTCADV-----VMKATALGDGRYEL--PAAPVSEIVSTGLSYAPDLIVESPEEARSEIIARL 322
Cdd:COG2378   227 gVFAGGPEPVTVTLRFSPEAARYLrerhpSQEIEELPDGSVRVtlTVADLDELARWLLSFGADVEVLEPEELREAVREEA 306

                  ....*...
gi 1092666999 323 EQVLARHG 330
Cdd:COG2378   307 RRLLARYE 314
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
162-326 5.37e-25

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 99.26  E-value: 5.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 162 FSTLLTAMTSpRRTVEMWYsRQYGVDDELRMLEPWGLINLRGRFYVLGFDPQREAARMFRLSRIRDVSDTGTSATqpMPD 241
Cdd:pfam13280   3 LETLREAILE-RRRVRFRY-RSPRGEGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFE--PPD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 242 GDLQQIAENMLHRGGKTYQAVVRIAPNTCADVV------MKAT-ALGDG--RYELPAAPVSEIVSTGLSYAPDLIVESPE 312
Cdd:pfam13280  79 FDLAEYLRRSFGVFPGPIEVKLRFSPEAARRLRerrfpdQQIEeEDDDGslRVTLPVDDLEELARWLLSFGPDVEVLEPP 158
                         170
                  ....*....|....
gi 1092666999 313 EARSEIIARLEQVL 326
Cdd:pfam13280 159 ELREEVREEAKRLL 172
 
Name Accession Description Interval E-value
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
18-330 2.40e-33

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 125.19  E-value: 2.40e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  18 TQRQVQLLLALADdTGWVSESWISKHVEgysrVSEdsraRYLRADTAALLAAGVPVEvsssSAGDKVKRLRLNRlRWTQH 97
Cdd:COG2378     4 LERLLALLQLLQS-RRGVTAAELAERLE----VSE----RTIYRDIDALRELGVPIE----AERGRGGGYRLRD-GYRLP 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999  98 DPEFTEAEASVVFQAAN--AAFGSEELSSTAVAAWRKLASF---AQRSAIAKPDESVVVADAVDMSRVDFSTLLTAMTSp 172
Cdd:COG2378    70 PLMLTEEEALALLLALRllAALGGAPLAEAAASALAKLEAVlpeRLRERLEALAERVGVDPPPEVDPEVLETLREAIRE- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 173 RRTVEMWYSRQYGvDDELRMLEPWGLINLRGRFYVLGFDPQREAARMFRLSRIRDVSDTGTSATQPmPDGDLQQIAEN-- 250
Cdd:COG2378   149 RRRLRIDYRSGRG-EPTERTVEPYGLVFYGGRWYLVAWCELRDDIRTFRLDRIRSLELTDERFEPP-PDFDLAEYLAEgf 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 251 -MLHRGGKTYQAVVRIAPNTCADV-----VMKATALGDGRYEL--PAAPVSEIVSTGLSYAPDLIVESPEEARSEIIARL 322
Cdd:COG2378   227 gVFAGGPEPVTVTLRFSPEAARYLrerhpSQEIEELPDGSVRVtlTVADLDELARWLLSFGADVEVLEPEELREAVREEA 306

                  ....*...
gi 1092666999 323 EQVLARHG 330
Cdd:COG2378   307 RRLLARYE 314
WYL pfam13280
WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the ...
162-326 5.37e-25

WYL domain; WYL is a Sm-like SH3 beta-barrel fold containing domain. It is a member of the WYL-like superfamily, named for three conserved amino acids found in a subset of the superfamily. However, these residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. A WYL domain protein (sll7009) is a negative regulator of the I-D CRISPR-Cas system in Synechocystis sp. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system.


Pssm-ID: 433082  Cd Length: 172  Bit Score: 99.26  E-value: 5.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 162 FSTLLTAMTSpRRTVEMWYsRQYGVDDELRMLEPWGLINLRGRFYVLGFDPQREAARMFRLSRIRDVSDTGTSATqpMPD 241
Cdd:pfam13280   3 LETLREAILE-RRRVRFRY-RSPRGEGTERTVEPYGLVYKDGRWYLVAYCRLRDDIRTFRLDRIESVEVLDEPFE--PPD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092666999 242 GDLQQIAENMLHRGGKTYQAVVRIAPNTCADVV------MKAT-ALGDG--RYELPAAPVSEIVSTGLSYAPDLIVESPE 312
Cdd:pfam13280  79 FDLAEYLRRSFGVFPGPIEVKLRFSPEAARRLRerrfpdQQIEeEDDDGslRVTLPVDDLEELARWLLSFGPDVEVLEPP 158
                         170
                  ....*....|....
gi 1092666999 313 EARSEIIARLEQVL 326
Cdd:pfam13280 159 ELREEVREEAKRLL 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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