|
Name |
Accession |
Description |
Interval |
E-value |
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
10-910 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1471.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 10 RADKLPKSWNPADVESDLYQGWVDAGYFKADPSSSKPaYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWL 89
Cdd:PRK05729 1 MMMELPKTYDPKEVEAKWYQKWEEKGYFKPDDNSKKP-FSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 90 PGMDHAGIATQTKVEAMLKEsEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTI 169
Cdd:PRK05729 80 PGTDHAGIATQMVVERQLAA-EGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 170 FKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGELVSFRYG--DGEDSIVVATTRVETMLGDVAIAVHPEDERY 247
Cdd:PRK05729 159 FVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPlaDGSDYLVVATTRPETMLGDTAVAVNPEDERY 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 248 THLVGKVLDHPF--REdlkIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRIFNTGTRFDGMDR 325
Cdd:PRK05729 239 KHLIGKTVILPLvgRE---IPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 326 AEARTALTEALREQGRIVKeIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVIHPASQEPRWFDW 405
Cdd:PRK05729 316 FEARKAIVADLEELGLLVK-IEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEIKFVPERWEKTYFHW 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 406 VDDMHDWCISRQLWWGHRIPIWYGPNGEVVCVGPDDEVPTGEGWTQDPDVLDTWFSSALWPFSTMGWPDATPELEKFYPT 485
Cdd:PRK05729 395 MENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKALLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPT 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 486 SVLVTGYDILFFWVARMMMFSTFAatladsplgkgrdgRPQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGA 565
Cdd:PRK05729 475 SVLVTGFDIIFFWVARMIMMGLHF--------------TGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGA 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 566 DALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMN--GAHVGELPDRDQLTDTDRWILDRLEQVRAEVDAA 643
Cdd:PRK05729 541 DALRFTLAALASPGRDIRFDEERVEGYRNFANKLWNASRFVLMNleGADVGELPDPEELSLADRWILSRLNRTVAEVTEA 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 644 LDKYEFSKANEALYHFAWDEVCDWYLEMTKVDFprlndgetmteeQAARAASTRLVLGRVLDTLLRLLHPSMPFVTETLW 723
Cdd:PRK05729 621 LDKYRFDEAARALYEFIWNEFCDWYLELAKPVL------------QEAAKRATRATLAYVLEQILRLLHPFMPFITEELW 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 724 KALTDgaEGFEDSLVISAWPDATmtadgAAVDEVAARRIADAQKLVTELRRFRNDQGVKPSQRVPARMNLADAD----LA 799
Cdd:PRK05729 689 QKLAP--LGIEESIMLAPWPEAD-----EAIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEdrarLE 761
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 800 AQEEMIRSLARAEAPEDGFTATA----SIEVRLSQATVLIELDtsGTVDVAAERKRLEKDLAKAEKELAGTEKKLGNEAF 875
Cdd:PRK05729 762 ANEAYIKRLARLESLEILADDEEapegAASAVVGGAELFLPLE--GLIDVEAELARLEKELAKLEKEIERVEKKLSNEGF 839
|
890 900 910
....*....|....*....|....*....|....*
gi 1092670728 876 LSKAPEQVVEKIKTRHQFALEEIDRIKARLEGLPQ 910
Cdd:PRK05729 840 VAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
12-908 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1447.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 12 DKLPKSWNPADVESDLYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPG 91
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 92 MDHAGIATQTKVEAMLKEsEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFK 171
Cdd:COG0525 81 TDHAGIATQAVVERQLAE-EGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 172 ELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGELVSFRYG--DGEDSIVVATTRVETMLGDVAIAVHPEDERYTH 249
Cdd:COG0525 160 RLYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPlaDGSGYIVVATTRPETMLGDTAVAVHPEDERYKH 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 250 LVGKVLDHPF--REdlkIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRIFNTGTRFDGMDRAE 327
Cdd:COG0525 240 LIGKTVILPLvgRE---IPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFE 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 328 ARTALTEALREQGRIVKeIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVIHPASQEPRWFDWVD 407
Cdd:COG0525 317 ARKAIVADLEELGLLVK-VEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIKFVPERWEKTYFHWME 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 408 DMHDWCISRQLWWGHRIPIWYGPNGEVVCVGPDDEVP---TGEGWTQDPDVLDTWFSSALWPFSTMGWPDATPELEKFYP 484
Cdd:COG0525 396 NIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACakaGSVNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYP 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 485 TSVLVTGYDILFFWVARMMMFSTFAatladsplgkgrdgRPQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYG 564
Cdd:COG0525 476 TSVLVTGFDIIFFWVARMIMMGLHF--------------TGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYG 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 565 ADALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMN--GAHVGELPDRDQLTDTDRWILDRLEQVRAEVDA 642
Cdd:COG0525 542 ADALRFTLAALASPGRDIKFDEERVEGYRNFANKLWNASRFVLMNleGFDPGLDPDPEELSLADRWILSRLNKTIAEVTE 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 643 ALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGEtmteeqAARAASTRLVLGRVLDTLLRLLHPSMPFVTETL 722
Cdd:COG0525 622 ALEKYRFDEAAQALYDFVWNEFCDWYLELAK---PRLYGGD------EAAKRETRATLVYVLEQILRLLHPFMPFITEEI 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 723 WKALTDGAEGfeDSLVISAWPdatmTADGAAVDEVAARRIADAQKLVTELRRFRNDQGVKPSQRVPARMNLADAD----L 798
Cdd:COG0525 693 WQKLPPRKEG--ESIMLAPWP----EADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEAdrarL 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 799 AAQEEMIRSLARAEAPE----DGFTATASIEVRlsQATVLIELdtSGTVDVAAERKRLEKDLAKAEKELAGTEKKLGNEA 874
Cdd:COG0525 767 EENAAYIKRLARLEEITilvdEKPEGAASAVVG--GAEVFLPL--EGLIDVEAERARLEKELAKLEKEIARVEKKLSNEG 842
|
890 900 910
....*....|....*....|....*....|....
gi 1092670728 875 FLSKAPEQVVEKIKTRHQFALEEIDRIKARLEGL 908
Cdd:COG0525 843 FVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARL 876
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
14-886 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1045.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 14 LPKSWNPADVESDLYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMD 93
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 94 HAGIATQTKVEAMLKEsEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKEL 173
Cdd:TIGR00422 81 HAGIATQVKVEKKLGA-EGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 174 FDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGELVSFRY---GDGEDSIVVATTRVETMLGDVAIAVHPEDERYTHL 250
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYplaNGSKDYLVVATTRPETMFGDTAVAVHPEDERYKHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 251 VGKVLDHPFrEDLKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRIFNTGTRFDGMDRAEART 330
Cdd:TIGR00422 240 IGKKVILPL-TGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 331 ALTEALREQGRIVKeIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVIHPASQEPRWFDWVDDMH 410
Cdd:TIGR00422 319 KIVEDLKEEGLLVK-IEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGEIKFVPKRMEKRYLNWLRNIK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 411 DWCISRQLWWGHRIPIWYGPN-GEVV----CVGPDDEVPTGEG--WTQDPDVLDTWFSSALWPFSTMGWPDATPELEKFY 483
Cdd:TIGR00422 398 DWCISRQLIWGHRIPVWYCKEcGEVYvakeEPLPDDKTNTGPSveLEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFY 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 484 PTSVLVTGYDILFFWVARMMMFStFAATladsplgkgrdgrPQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDY 563
Cdd:TIGR00422 478 PTDLLVTGYDIIFFWVARMIFRS-LALT-------------GQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKY 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 564 GADALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGAHVGELP-DRDQLTDTDRWILDRLEQVRAEVDA 642
Cdd:TIGR00422 544 GADALRFTLASLVTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLELSgGEEKLSLADRWILSKLNRTIKEVRK 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 643 ALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGetmtEEQAARAAstRLVLGRVLDTLLRLLHPSMPFVTETL 722
Cdd:TIGR00422 624 ALDKYRFAEAAKALYEFIWNDFCDWYIELVK---YRLYNG----NEAEKKAA--RDTLYYVLDKALRLLHPFMPFITEEI 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 723 WKALTDGAegfeDSLVISAWPdatmTADGAAVDEVAARRIADAQKLVTELRRFRNDQGVKPSQRVPARMNLADADLAA-Q 801
Cdd:TIGR00422 695 WQHFKEGA----DSIMLQSYP----VVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAErL 766
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 802 EEMIRSLARAEAPEDGF--TATASIEVRLSQATVLIE--LDTSGTVDVAAERKRLEKDLAKAEKELAGTEKKLGNEAFLS 877
Cdd:TIGR00422 767 KLNAVDIKGAINFSEVEvvIEKPEVTEAVVELVPGFEiiIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVK 846
|
....*....
gi 1092670728 878 KAPEQVVEK 886
Cdd:TIGR00422 847 KAPKEVIEK 855
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
13-889 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 917.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 13 KLPKSWNPADVESDLYQGWVDAGYFK----ADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLW 88
Cdd:PTZ00419 23 SMAASYDPKEVESGWYEWWEKSGFFKpaedAKSLNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 89 LPGMDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQT 168
Cdd:PTZ00419 103 VPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 169 IFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAE----------------GELVSFRY---GDGEDSIVVATTRV 229
Cdd:PTZ00419 183 AFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYpleDSGQEEIVVATTRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 230 ETMLGDVAIAVHPEDERYTHLVGKVLDHPFREDLKIQVIADD-YVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVID 308
Cdd:PTZ00419 263 ETMLGDVAVAVHPKDERYKKLHGKELIHPFIPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFT 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 309 TTGRIFNTGTRFDGMDRAEARTALTEALREQGrIVKEIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVRE 388
Cdd:PTZ00419 343 LDGKINENGGEFAGMHRFDCRRKIEEELKEMG-LLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRN 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 389 GDTVIHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWygpngEVVCVGPDDEVPTGEGW------------------- 449
Cdd:PTZ00419 422 GELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAY-----RVISKGPETDPSDEEPWvvarseeealekakkkfgl 496
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 450 -------TQDPDVLDTWFSSALWPFSTMGWPDATPELEKFYPTSVLVTGYDILFFWVARMMMFSTfaaTLADsplgkgrd 522
Cdd:PTZ00419 497 seedfelEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSL---HLTD-------- 565
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 523 grpQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWV------------------------------RDY-------GA 565
Cdd:PTZ00419 566 ---KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIegislqdlnqklyegnlpekeikraielqkKEFpngipecGT 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 566 DALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGAHVGELP--------DRDQLTDTDRWILDRLEQVR 637
Cdd:PTZ00419 643 DALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPnstlfkpnNVESLPWEDKWILHRLNVAI 722
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 638 AEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKVDFPRLNDGEtmteeqaaRAASTRLVLGRVLDTLLRLLHPSMPF 717
Cdd:PTZ00419 723 KEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGE--------RKQHAQDVLHTVLDIGLRLLHPMMPF 794
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 718 VTETLWKALTDGAEGFEdSLVISAWPDATMTADGAAVDEvAARRIADAQKLVTELRRFRN-DQGVKPSQRVPARMNLADA 796
Cdd:PTZ00419 795 ITEELYQRLPNYLRKSE-SISIAKYPQPNPGWNNEALDE-EMKIIMSIVKSIRSLIATLGiPNKTKPDCYVTAKDAELIE 872
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 797 DLAAQEEMIRSLARAEAPEDGFTATASIEVR------LSQATVLIELDTSGTVDVAAERKRLEKDLAKAEKELAGTEKKL 870
Cdd:PTZ00419 873 LIESAENLISTLAKIGSVSVIPPIEEEAEVPkgcgfdVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKI 952
|
970 980
....*....|....*....|...
gi 1092670728 871 GNEAFLSKAPEQV----VEKIKT 889
Cdd:PTZ00419 953 SIPNYEDKVPEDVrklnDEKIDE 975
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
4-906 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 874.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 4 NNVDLNRADKLPKSWNPADVESDLYQGWVDAGYFKADPS-SSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQ 82
Cdd:PRK14900 5 NPIENENRTELAKGYEHREVEARWYPFWQERGYFHGDEHdRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMS 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 83 GYEVLWLPGMDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGL 162
Cdd:PRK14900 85 GFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 163 SRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDA-EGELVSFRY--GDGEDSIVVATTRVETMLGDVAIA 239
Cdd:PRK14900 165 SRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAhQGELWSFAYplADGSGEIVVATTRPETMLGDTAVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 240 VHPEDERYTHLVGKVLDHPFrEDLKIQVIAD-DYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRIFNTGT 318
Cdd:PRK14900 245 VHPLDPRYMALHGKKVRHPI-TGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 319 RFDGMDRAEARTALTEALREQGRIVKEiRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVIHPASQ 398
Cdd:PRK14900 324 PLAGLDRFEARKEVKRLLAEQGLDRGA-KPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTRFIPEQW 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 399 EPRWFDWVDDMHDWCISRQLWWGHRIPIWYGPNGEVVCVgpdDEVPT------GEGWTQDPDVLDTWFSSALWPFSTMGW 472
Cdd:PRK14900 403 TNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVA---RETPEacstcgKAELRQDEDVLDTWFSSGLWPFSTMGW 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 473 PDATPELEKFYPTSVLVTGYDILFFWVARMMMFstfaatladsplgkGRDGRPQVPFKDVFLHGLVRDEQGRKMSKSLGN 552
Cdd:PRK14900 480 PEQTDTLRTFYPTSVMETGHDIIFFWVARMMMM--------------GLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGN 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 553 GIDPLDWVRDYGADALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGA---HVGELPDRDQLTDTDRWI 629
Cdd:PRK14900 546 VIDPLVITEQYGADALRFTLAALTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLSgyqERGEDPARLARTPADRWI 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 630 LDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfprlndgETMTEEQAARAASTRLVLGRVLDTLLR 709
Cdd:PRK14900 626 LARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAK---------EALASEDPEARRSVQAVLVHCLQTSYR 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 710 LLHPSMPFVTETLWKAL--TDGAEGFEDSLVISAWPDAtmtadgAAVDEVAARRIADAQKLVTELRRFRNDQGVKPSQRV 787
Cdd:PRK14900 697 LLHPFMPFITEELWHVLraQVGASAWADSVLAAEYPRK------GEADEAAEAAFRPVLGIIDAVRNIRGEMGIPWKVKL 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 788 PARMN--LADADLAAQE-------------------EMIRSLARAEAPEDGFTATASIEVRLSQAtvlieldtsGTVDVA 846
Cdd:PRK14900 771 GAQAPveIAVADPALRDllqagelarvhrvagvegsRLVVAAATAPAPQSAVGVGPGFEVRVPLA---------GVIDLA 841
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 847 AERKRLEKDLAKAEKELAGTEKKLGNEAFLSKAPEQVVEKIKTRhqfaLEEIDRIKARLE 906
Cdd:PRK14900 842 AETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRAR----AEELREKRGKLE 897
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
2-908 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 748.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 2 TENNVdlNRADKLPKSWNPADvESDLYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRM 81
Cdd:PLN02943 47 SENDV--FTSPETAKSFDFTS-EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRM 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 82 QGYEVLWLPGMDHAGIATQTKVEAMLKeSEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEG 161
Cdd:PLN02943 124 KGRPTLWIPGTDHAGIATQLVVEKMLA-SEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQ 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 162 LSRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGELVSFRY---GDGEDSIVVATTRVETMLGDVAI 238
Cdd:PLN02943 203 LSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYrvaGGSEDFLTIATTRPETLFGDVAI 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 239 AVHPEDERYTHLVGKVLDHPFREDLKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGrifnTGT 318
Cdd:PLN02943 283 AVNPEDDRYSKYIGKMAIVPMTYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDG----TLN 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 319 RFDGMDRAEARTALTEALREQGRIVKEiRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVIHPASQ 398
Cdd:PLN02943 359 EVAGLYWFEAREKLWSDLEETGLAVKK-EPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 399 EPRWFDWVDDMHDWCISRQLWWGHRIPIWY--GPNGE---VVCVGPDDEVPTGEG-------WTQDPDVLDTWFSSALWP 466
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYivGKDCEedyIVARSAEEALEKAREkygkdveIYQDPDVLDTWFSSALWP 517
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 467 FSTMGWPD-ATPELEKFYPTSVLVTGYDILFFWVARM-MMFSTFAATladsplgkgrdgrpqVPFKDVFLHGLVRDEQGR 544
Cdd:PLN02943 518 FSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMvMMGIEFTGT---------------VPFSYVYLHGLIRDSQGR 582
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 545 KMSKSLGNGIDPLDWVRDYGADALRFTLARGaNPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGAHVGELPDRDQLTD 624
Cdd:PLN02943 583 KMSKTLGNVIDPLDTIKEFGTDALRFTLALG-TAGQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSDTSAWEHILA 661
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 625 --------------TDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKVdfpRLNDGETMTEEQA 690
Cdd:PLN02943 662 ckfdkeesllslplPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKT---RLYHSGDNSALSR 738
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 691 ARAastrlVLGRVLDTLLRLLHPSMPFVTETLWKALTDGAEgfedSLVISAWPDATMTADGAAVdevaaRRIADAQKLVT 770
Cdd:PLN02943 739 AQA-----VLLYVFENILKLLHPFMPFVTEELWQALPYRKE----ALIVSPWPQTSLPKDLKSI-----KRFENLQSLTR 804
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 771 ELRRFRNDQGVKPSQRVPARMnLADAD----LAAQEEMIRSLARAEAPEDGFTATASIEVRLSQATVLIE-----LDTSG 841
Cdd:PLN02943 805 AIRNARAEYSVEPAKRISASI-VASAEvieyISKEKEVLALLSRLDLQNVHFTDSPPGDANQSVHLVASEgleayLPLAD 883
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1092670728 842 TVDVAAERKRLEKDLAKAEKELAGTEKKLGNEAFLSKAPEQVVEKIKTRHQFALEEIDRIKARLEGL 908
Cdd:PLN02943 884 MVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKLTKNRLAFL 950
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
11-906 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 693.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 11 ADKLPKSWNPADVESDLYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLP 90
Cdd:PLN02381 93 SSQMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVP 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 91 GMDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIF 170
Cdd:PLN02381 173 GVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAF 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 171 KELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAE----------------GELVSFRY----GDGEdsIVVATTRVE 230
Cdd:PLN02381 253 VRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYplegGLGE--IVVATTRIE 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 231 TMLGDVAIAVHPEDERYTHLVGKVLDHPFrEDLKIQVIAD-DYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDT 309
Cdd:PLN02381 331 TMLGDTAIAIHPDDERYKHLHGKFAVHPF-NGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTD 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 310 TGRI-FNTGTRFDGMDRAEARTALTEALREQGrIVKEIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVRE 388
Cdd:PLN02381 410 DGKInSNGGSEFAGMPRFAAREAVIEALQKKG-LYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAID 488
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 389 GDTV---IHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWY-----------GPNGEVVCVGPDDEVPTGEG------ 448
Cdd:PLN02381 489 GENKkleFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtleddqlkelGSYNDHWVVARNESDALLEAsqkfpg 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 449 ----WTQDPDVLDTWFSSALWPFSTMGWPDATPELEKFYPTSVLVTGYDILFFWVARMMMFstfaatladsplgkGRDGR 524
Cdd:PLN02381 569 kkfeLSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMM--------------GMQLG 634
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 525 PQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWV------------------------------RDY-------GADA 567
Cdd:PLN02381 635 GDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVIngisleglhkrleegnldpkelvvakegqkKDFpngiaecGTDA 714
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 568 LRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMN-GAHVgeLP----DRDQLTDTDRWILDRLEQVRAEVDA 642
Cdd:PLN02381 715 LRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKlGDDY--TPpatlSVETMPFSCKWILSVLNKAISKTVS 792
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 643 ALDKYEFSKANEALYHFAWDEVCDWYLEMTKVDFprLNDGETMTEEQAAraasTRLVLGRVLDTLLRLLHPSMPFVTETL 722
Cdd:PLN02381 793 SLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYF--AGDNPEFASERAA----AQDTLWICLDTGLRLLHPFMPFVTEEL 866
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 723 WKALTDGAEGF-EDSLVISAWPdatmTADGAAVDEVAARRIADAQKLVTELRRFRndQGVKPSQ---RVPA----RMNLA 794
Cdd:PLN02381 867 WQRLPQPKDHTrKDSIMISEYP----SAVEAWTNEKVEYEMDLVLSTVKCLRSLR--AEVLEKQkneRLPAfalcRNQEI 940
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 795 DADLAAQEEMIRSLA----------RAEAPEDGfTATASIEVRLSqatvlIELDTSGTVDVAAERKRLEKDLAKAEKELA 864
Cdd:PLN02381 941 AAIIKSHQLEILTLAnlsslkvllsENDAPPAG-CAFENVNENLK-----VYLQAQGAVNAEAELEKLRNKMDEIQKQQE 1014
|
970 980 990 1000
....*....|....*....|....*....|....*....|....*
gi 1092670728 865 GTEKKLGNEAFLSKAPEQVVEKIKTRHQFALEEIDRIK---ARLE 906
Cdd:PLN02381 1015 KLEKKMNASGYKEKVPANIQEEDARKLTKLLQELEFFEkesKRLE 1059
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
26-582 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 660.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 26 DLYQGWVDAGYFKADPSSSK--PAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKV 103
Cdd:pfam00133 1 QIYEFWDEQGYFKPELEKRKgkPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 104 EAMLKESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAK 183
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 184 RMVNWSPVLQTAISDIEVKYEDAEGELVSFRY---GDGEDSIVVATTRVETMLGDVAIAVHPE----------------- 243
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFplaDDEGASLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 244 --------------DERYTHLVGKVLDHPFrEDLKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDT 309
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPF-VNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 310 TGRIFNTGTRFDGMDRAEARTALTEALREQGRIVKeIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVReg 389
Cdd:pfam00133 320 DGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLK-IEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE-- 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 390 DTVIHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWYGPN-GEVVCVGPDDEVP----TGEG---W------------ 449
Cdd:pfam00133 397 KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCRGELFELVagrfEEEGsikWlhreakdklgyg 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 450 ----TQDPDVLDTWFSSALWPFSTMGWPD-ATPELEKFYPTSVLVTGYDILFFWVARMMMFSTfaATladsplgkgrdgR 524
Cdd:pfam00133 477 kgtlEQDEDVLDTWFSSGSWPFSTLGWPFvNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLST--AL------------T 542
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*...
gi 1092670728 525 PQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLArGANPGSDL 582
Cdd:pfam00133 543 GSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLA-NSDYGRDI 599
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
13-812 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 586.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 13 KLPKSWNPADVESDLYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGM 92
Cdd:PRK13208 5 ELPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 93 DHAGIATQTKVEamlkESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKE 172
Cdd:PRK13208 85 DDNGLPTERKVE----KYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 173 LFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGEL--VSFRYGDGEDsIVVATTRVETMLGDVAIAVHPEDERYTHL 250
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLnyIKFPVEDGEE-IEIATTRPELLPACVAVVVHPDDERYKHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 251 VGKVLDHP-FREdlKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRIFNTGTRFDGMDRAEAR 329
Cdd:PRK13208 240 VGKTAIVPlFGV--EVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEAR 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 330 TALTEALREQGrIVKEIRPYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDtvIHPASQEPRWFDWVDDM 409
Cdd:PRK13208 318 KKIVEDLKSGG-LLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEIN--WYPEHMRVRLENWIEGL 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 410 H-DWCISRQLWWGHRIPIWYGPN-GEVV-------CVGPDDEVPTGE--------GWTQDPDVLDTWFSSALWPFSTMGW 472
Cdd:PRK13208 395 NwDWCISRQRYFGTPIPVWYCKDcGHPIlpdeedlPVDPTKDEPPGYkcpqcgspGFEGETDVMDTWATSSITPLIVTGW 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 473 PDATPELEKFYPTSVLVTGYDILFFWvarmmMFSTFAATLADspLGKgrdgrpqVPFKDVFLHGLVRDEQGRKMSKSLGN 552
Cdd:PRK13208 475 ERDEDLFEKVFPMDLRPQGHDIIRTW-----LFYTILRAYLL--TGK-------LPWKNIMISGMVLDPDGKKMSKSKGN 540
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 553 GIDPLDWVRDYGADALRFTLArGANPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGAHVgELPDRDQLTDTDRWILDR 632
Cdd:PRK13208 541 VVTPEELLEKYGADAVRYWAA-SARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADP-EPDKAEVLEPLDRWILAK 618
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 633 LEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGETMTEEQAARAAstrlvLGRVLDTLLRLLH 712
Cdd:PRK13208 619 LAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVK---SRAYGEDEEEEQKSARYT-----LYTVLDTLLRLLA 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 713 PSMPFVTETLWKALtdgaegFEDSLVISAWPdatmTADGAAVDEVAARRIADAQKLVTELRRFRNDQGVK---PSQRVPA 789
Cdd:PRK13208 691 PFLPFITEEVWSWL------YGGSVHRASWP----EPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSlnaPLKKVEV 760
|
810 820
....*....|....*....|...
gi 1092670728 790 RMNLADADLAAQEEMIRSLARAE 812
Cdd:PRK13208 761 YGPADLELLEAAEEDLKAAGNIE 783
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
46-583 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 548.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 46 PAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKVEAMLKeSEGKDRFDYGREEFVE 125
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLG-IEGKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 126 KVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVkyed 205
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 206 aegelvsfrygdgedsivvattrvetmlgdvaiavhpederythlvgkvldhpfredlkiqviaddyvdrefgtgavkit 285
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 286 pahdpndfamgqrhdldmpevidttgrifntgtrfdgmdraeartaltealreqgrivkeirpyvhsvghSERSGEPIEP 365
Cdd:cd00817 156 ----------------------------------------------------------------------CSRSGDVIEP 165
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 366 LLSLQWFVKVDELAKMSGDAVREGDTVIHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWYGPNGEVVCVGPDDEVP- 444
Cdd:cd00817 166 LLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAi 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 445 -----------TGEGWTQDPDVLDTWFSSALWPFSTMGWPDATPELEKFYPTSVLVTGYDILFFWVARMMMFSTFAATla 513
Cdd:cd00817 246 dkaapeacvpcGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTG-- 323
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 514 dsplgkgrdgrpQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSDLP 583
Cdd:cd00817 324 ------------KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDIN 381
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
13-784 |
2.47e-117 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 378.26 E-value: 2.47e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 13 KLPKSWNPADVESDLYQGWVDAGYFKADPSSSKPAYSIVL--PPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLP 90
Cdd:TIGR00392 1 KFPMRGNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFhdGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 91 GMDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWE--WKHDYGGRigNQMRQIGDSLDWSRERFTLDEGLSRAVQT 168
Cdd:TIGR00392 81 GWDTHGLPIEHKVEKKLGISGKKEISSLEIEEFREKCREfaLKQIEEQR--EQFQRLGVWGDWENPYKTMDPSYEESQWW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 169 IFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYEDAEGEL------VSFRYGDGED--------SIVVATTRVETMLG 234
Cdd:TIGR00392 159 LFKEAHEKGLLYRGLKPVYWSPRCRTALAEAEVEYKENYKDVkdpsiyVKFPVKKDKKtylkvklsSLLIWTTTPWTLPS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 235 DVAIAVHPE-----------DERY--------------------------THLVGKVLDHPFREDLKIQ------VIADD 271
Cdd:TIGR00392 239 NLAIAVHPDfeyalvqdntkVEYFilakklveklynkagsdyeiiktfkgSDLEGLEYEHPLYDFVSQLkegapvVIGGD 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 272 YVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTTGRiFNTGT--------RFDGMDRAEARTALTEALREQGRIV 343
Cdd:TIGR00392 319 HVTTEDGTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGV-YTEGVndfqgrfvKDADKDIIKANKIIIEQLKDKGLLL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 344 KEIRpYVHSVGHSERSGEPIEPLLSLQWFVKVDELAKMSGDAVREGDTVihPASQEPRWFDWVDDMHDWCISRQLWWGHR 423
Cdd:TIGR00392 398 KAEK-ITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWV--PEWGEGRFGNWLENRPDWCISRQRYWGIP 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 424 IPIWYGPN-GEVVCVGPDDEV----------------------------PTGEGWTQDPDVLDTWFSSALWPFSTMGWPD 474
Cdd:TIGR00392 475 IPIWYCEDtGEPIVVGSIEELielielkgidawfedlhrdfldkitlksGDGGEYRRVPDVLDVWFDSGSMPYASIHYPF 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 475 ATPELEKFYPTSVLVTGYDILFFWvarmmmFSTFAATladsplgkGRDGRPQVPFKDVFLHGLVRDEQGRKMSKSLGNGI 554
Cdd:TIGR00392 555 ENEKFKEVFPADFILEGSDQTRGW------FYSSLAI--------GTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVV 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 555 DPLDWVRDYGADALRFTLARgANPGSDLPVG-NDAAQSSRNFATKLFNATRFALMNGAHVGELPDRD-----QLTDTDRW 628
Cdd:TIGR00392 621 DPLKVINKYGADILRLYVAS-SDPWEDLRFSdEILKQVVEKYRKIRWNTYRFLLTYANLDKFDPLFNsvaveKFPEEDRW 699
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 629 ILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNdGETMTEEqaARAASTrlVLGRVLDTLL 708
Cdd:TIGR00392 700 ILSRLNSLVEEVNEALEKYNFHKVLRALQDFIVEELSNWYIRIIR---DRLY-CEAKDND--KRAAQT--TLYYALLTLV 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 709 RLLHPSMPFVTETLWKALTDGAEgfEDSLVISAWP-------DATMTADGAAVDEV--AARRIADAQKLvtELRRFRNDQ 779
Cdd:TIGR00392 772 RLLAPFLPHTAEEIYQNLPGGEE--EESVHLNLWPevdeefiDEALEANMAIVREIveAFLALRDAANK--KLRQPLKEL 847
|
....*
gi 1092670728 780 GVKPS 784
Cdd:TIGR00392 848 VIGKS 852
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
54-840 |
1.01e-112 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 367.87 E-value: 1.01e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 54 PPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMD-HaGIATQTKVEAMLKESeGKDRFDYGREEFVEK----VW 128
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GLPIELKVEKELGIK-KKDIEKVGIAEFREKcreyAL 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 129 EWkhdyggrIGNQMRQ---IGDSLDWSRERFTLD----EGLSRAvqtiFKELFDRGLIYRAKRMVNWSPVLQTAISDIEV 201
Cdd:COG0060 132 KY-------VDEQREDfkrLGVWGDWDNPYLTMDpeyeESIWWA----LKKLYEKGLLYKGLKPVPWCPRCGTALAEAEV 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 202 KYED------------AEGELVSfryGDGEDSIVVATTRVETMLGDVAIAVHPE----------DERY------------ 247
Cdd:COG0060 201 EYKDvtspsiyvkfpvKDEKALL---LLEDAYLVIWTTTPWTLPANLAVAVHPDidyvlvevtgGERLilaealveavlk 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 248 ---------------THLVGKVLDHPFRE----DLKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVID 308
Cdd:COG0060 278 elgiedyevlatfkgAELEGLRYEHPFYYvvgyDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVD 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 309 TTGRIFNTGTRFDGMDRAEARTALTEALREQGRIVKEiRPYVHSVGHSERSGEPI-----EpllslQWFVKVDELAKmsg 383
Cdd:COG0060 358 DDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAR-EKITHSYPHCWRCKTPLiyratP-----QWFISMDKLRD--- 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 384 DAVREGDTVI-HPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWYGPN-GEVV----CVG------------------- 438
Cdd:COG0060 429 RALEAIEKVNwIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDcGELHrteeVIGsvaelleeegadawfeldl 508
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 439 --P--DDEVP---TGEGWTQDPDVLDTWFSSALWPFSTM---------------------GWpdatpelekFYptSVLVT 490
Cdd:COG0060 509 hrPflDETLKcpkCGGTMRRVPDVLDVWFDSGSMHFAVLenreelhfpadfylegsdqtrGW---------FY--SSLLT 577
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 491 GydilffwvarMMMFstfaatladsplgkgrdGRPqvPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRF 570
Cdd:COG0060 578 S----------TALF-----------------GRA--PYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRL 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 571 TLARgANPGSDLPVGNDAAQSSRNFATKLFNATRFALMNGAH---VGELPDRDQLTDTDRWILDRLEQVRAEVDAALDKY 647
Cdd:COG0060 629 WVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLDDfdpAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNY 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 648 EFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGEtmTEEQAARAASTrlVLGRVLDTLLRLLHPSMPFVTETLWKALT 727
Cdd:COG0060 708 DFHRAYRALHNFCVEDLSNWYLDISK---DRLYTEA--ADSLDRRAAQT--TLYEVLETLVRLLAPILPFTAEEIWQNLP 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 728 DGAegfEDSLVISAWPDatmtADGAAVDEVAARRIADAQKLVTELRRF----RNDQGV-KPSQRVPARmnLADADLAAQ- 801
Cdd:COG0060 781 GEA---EESVHLADWPE----VDEELIDEELEAKWDLVREVRSAVLKAleaaRKEKLIrQPLEAAVVL--YADEELAAAl 851
|
890 900 910 920
....*....|....*....|....*....|....*....|....*..
gi 1092670728 802 --------EEMIRSLARAEAPEDGFTATASIEVRLSQATVLIELDTS 840
Cdd:COG0060 852 eslgdllaEELNVSEVELVDDAEDLGKDALKALDVEGISVTVEVEKA 898
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
48-584 |
1.99e-74 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 246.56 E-value: 1.99e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 48 YSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKVEAmLKESEGKDRFdygREEFVEKV 127
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAER-KGGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 128 WEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRmvnwspvlqtaisdievkyedae 207
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH----------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 208 gelvsfrygdgedsivvattrvetmlgdvaiavhpederythlvgkvldhpfredlkiqviaddyvdrefgtgAVKITPa 287
Cdd:cd00668 135 -------------------------------------------------------------------------PVRITE- 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 288 hdpndfamgqrhdldmpevidttgrifntgtrfdgmdraeartaltealreqgrivkeirpyvhsvghsersgepiepll 367
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 368 slQWFVKVDELAKMSGDAVREGDTVihPASQEPRWFDWVDDMHDWCISRQLWWGHRIPiwygpngevvcvgpddevptge 447
Cdd:cd00668 141 --QWFFDMPKFKEKLLKALRRGKIV--PEHVKNRMEAWLESLLDWAISRQRYWGTPLP---------------------- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 448 gwtqdPDVLDTWFSSALWPFSTMGWPDATPELEKFYPTSVLVTGYDILFFWVARMMMfstfaatladspLGKGRDGrpQV 527
Cdd:cd00668 195 -----EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWIT------------MLVALFG--EI 255
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 1092670728 528 PFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSDLPV 584
Cdd:cd00668 256 PPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
54-849 |
1.43e-66 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 240.83 E-value: 1.43e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 54 PPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKVEAMLKESEGKD----RFDYGREEFVEKVwe 129
Cdd:PLN02843 40 PPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELKVLQSLDQEARKEltpiKLRAKAAKFAKKT-- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 130 wkhdyggrIGNQMRQI---GDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKYedA 206
Cdd:PLN02843 118 --------VDTQRESFkryGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEY--P 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 207 EGEL-----VSFRYGDGED-------------SIVVATTRVETMLGDVAIAVHP-------------EDERY-------- 247
Cdd:PLN02843 188 EGHVsksiyVAFPVVSPSEtspeeleeflpglSLAIWTTTPWTMPANAAVAVNDklqysvvevqsfsEDESTsggnkkkr 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 248 ----------------THLVGKVLD-----------------------HPFREDLKIQVIADDYVDREFGTGAVKITPAH 288
Cdd:PLN02843 268 pgnvlkeqqklflivaTDLVPALEAkwgvklvvlktfpgsdlegcryiHPLYNRESPVVIGGDYITTESGTGLVHTAPGH 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 289 DPNDFAMGQRHDLDMPEVIDTTGRIFNTGTRFDGMD-RAEARTALTEALREQGRIVKEiRPYVHSVGHSERSGEPIEPLL 367
Cdd:PLN02843 348 GQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSvLGEGNAAVVEALDEAGSLLME-EAYGHKYPYDWRTKKPTIFRA 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 368 SLQWFVKVDELAKMSGDAVREGDTVihPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWY------------------- 428
Cdd:PLN02843 427 TEQWFASVEGFRQAALDAIDKVKWI--PAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYhvetkeplmneetiahvks 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 429 -----GPNG----EVVCVGPDDEVPTGEGWTQDPDVLDTWFSSALwpfSTMGWPDATPELEkfYPTSVLVTGYDILFFWv 499
Cdd:PLN02843 505 ivaqkGSDAwwymDVEDLLPEKYRDKASDYEKGTDTMDVWFDSGS---SWAGVLGSREGLS--YPADLYLEGSDQHRGW- 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 500 armmmfstFAATLADSPLGKGrdgrpQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRD---------YGADALRF 570
Cdd:PLN02843 579 --------FQSSLLTSVATKG-----KAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEGgknqkqepaYGADVLRL 645
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 571 TLArGANPGSDLPVGNDAAQSSRNFATKLFNATRFALmngahvGELPD--------RDQLTDTDRWILDRLEQVRAEVDA 642
Cdd:PLN02843 646 WVA-SVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLL------GNLHDwkpdnavpYEDLPSIDKYALFQLENVVNEIEE 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 643 ALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGEtmTEEQAARAASTrlVLGRVLDTLLRLLHPSMPFVTETL 722
Cdd:PLN02843 719 SYDNYQFFKIFQILQRFTIVDLSNFYLDVAK---DRLYVGG--TTSFTRRSCQT--VLAAHLLSLLRAIAPILPHLAEDA 791
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 723 WKALTDGAEGFEDSLV-ISAWPDATMTADGAAVDEVAA-RRIADAQKLVTE-LRRFRNDQGVKPSQRVPARMNLADADLA 799
Cdd:PLN02843 792 WQNLPFQEDGSAAESVfEAGWPTPNEEWLSFPAEDVDFwSLLLEVRDEVNKvLESARNGKLIGASLEAKVYLHASDASLA 871
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*....
gi 1092670728 800 AQ-EEMIRSLARAEAPEDGFTaTASIEVRLSQATVLI--------ELDTSGTVDVAAER 849
Cdd:PLN02843 872 ARlAELCGASNGADELRRIFI-TSQVEVVSSEDDETAacgsytgeYVEGAGRVWVGVSR 929
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
591-726 |
4.61e-52 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 178.13 E-value: 4.61e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 591 SSRNFATKLFNATRFALMN-GAHVGELPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYL 669
Cdd:cd07962 8 GGRNFCNKLWNAARFVLMNlEDDDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFWNDFCDWYL 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1092670728 670 EMTKvdfPRLNDGEtmteeqAARAASTRLVLGRVLDTLLRLLHPSMPFVTETLWKAL 726
Cdd:cd07962 88 ELVK---PRLYGED------EEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
14-760 |
2.82e-51 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 196.10 E-value: 2.82e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 14 LPKSWNPADVESDLYQGWVDAGYFKADPSSS--KPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPG 91
Cdd:PLN02882 4 EGKDFSFPKQEEKILSLWSEIDAFKTQLKRTegLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 92 MDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEK--------VWEWKhdyggrigNQMRQIGDSLDWSRERFTLDEGLS 163
Cdd:PLN02882 84 WDCHGLPVEYEIDKKLGIKRRDDVLKMGIDKYNEEcrsivtrySKEWE--------KTVTRTGRWIDFENDYKTMDPKFM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 164 RAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEV--KYEDAEGE--LVSFRYGDGED--SIVVATTRVETMLGDVA 237
Cdd:PLN02882 156 ESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPavMVSFPIVGDPDnaSFVAWTTTPWTLPSNLA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 238 IAVHPE-----------------------------------------DERY--------THLVGKVLD--HPFREDLK-- 264
Cdd:PLN02882 236 LCVNPNftyvkvrnkytgkvyivaesrlsalptakpkskkgskpenaAEGYevlakvpgSSLVGKKYEplFDYFSEFSdt 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 265 -IQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDL-----DMPEVIDTTGRIFNTGTRFDGMDRAEARTALTEALRE 338
Cdd:PLN02882 316 aFRVVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKA 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 339 QGRIVKEIRpYVHSVGHSERSGEPIEPLLSLQWFVKVDELAkmsgDAVREGDTVIH--PAS-QEPRWFDWVDDMHDWCIS 415
Cdd:PLN02882 396 KGRLVKSGS-ITHSYPFCWRSDTPLIYRAVPSWFVKVEEIK----DRLLENNKQTYwvPDYvKEKRFHNWLENARDWAVS 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 416 RQLWWGHRIPIWYGPNG-EVVCVGPDDE---------------------VPTGEGWTQDP-----DVLDTWFSSALWPFS 468
Cdd:PLN02882 471 RSRFWGTPLPIWISDDGeEVVVIGSIAEleklsgvkvtdlhrhfidhitIPSSRGPEFGVlrrvdDVFDCWFESGSMPYA 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 469 TMGWPDATPEL-EKFYPTSVLVTGYDILFFWVARMMMFSTfaaTLADSPlgkgrdgrpqvPFKDVFLHGLVRDEQGRKMS 547
Cdd:PLN02882 551 YIHYPFENKELfEKNFPADFVAEGLDQTRGWFYTLMVLST---ALFDKP-----------AFKNLICNGLVLAEDGKKMS 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 548 KSLGNGIDPLDWVRDYGADALRFTLArganpgsDLPVGNdaAQSSRnFATK------------LFNATRFALMN------ 609
Cdd:PLN02882 617 KSLKNYPDPNEVIDKYGADALRLYLI-------NSPVVR--AEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQNakrlev 686
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 610 --GAHVGELpDRDQLTDT----DRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAwDEVCDWYLEMTKvdfPRLNdGE 683
Cdd:PLN02882 687 egGAPFVPL-DLAKLQNSanvlDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNR---KRLK-GR 760
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1092670728 684 TmTEEQAARAASTrlvLGRVLDTLLRLLHPSMPFVTETLWKALTDGAEGFEDSLVISAWPDATMTADGAAVDEVAAR 760
Cdd:PLN02882 761 T-GEEDCRTALST---LYNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGSEESIHYCSFPQVDEGELDERIEQSVSR 833
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
19-757 |
3.74e-48 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 184.48 E-value: 3.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 19 NPADVESDLYQGWVDAGYFKADPSSSKPAYSIV--LPPPnvTGQLHMGHALDHTLMDALVRRKRMQGYEVL----W---- 88
Cdd:COG0495 6 NPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLdmFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhpmgWdafg 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 89 LP--------GMdHAGIATQTKVEAMLKesegkdrfdygreefvekvwewkhdyggrignQMRQIGDSLDWSRERFTLDE 160
Cdd:COG0495 84 LPaenaaiknGV-HPAEWTYENIANMRR--------------------------------QLKRLGLSYDWSREIATCDP 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 161 GLSRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEV-------------------------KYED---------- 205
Cdd:COG0495 131 EYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVidgrcwrcgapvekkelpqwflkitDYADellddldkld 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 206 ----------------AEGELVSFRYGDGEDSIVVATTRVETMLGD--VAIAV-HPederythLVGKVLDHPFREDL--- 263
Cdd:COG0495 211 gwpekvktmqrnwigrSEGAEVDFPVEGSDEKITVFTTRPDTLFGAtfMVLAPeHP-------LVKELATPEQNAAVaaf 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 264 -----------------------------------KIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVID 308
Cdd:COG0495 284 ieeakkkseiertsetkektgvftglyainpltgeKIPIWIADYVLMDYGTGAVMAVPAHDQRDFEFAKKYGLPIKQVIA 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 309 TT---------------GRIFNTGtRFDGMDRAEARTALTEALREQGRIVKEIrpyvhsvghsersgepiepllslQWfv 373
Cdd:COG0495 364 PEdgddpdileeaytgdGVLINSG-EFDGLDSEEAKEAIIEWLEEKGLGKRKV-----------------------NY-- 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 374 kvdelakmsgdavRegdtvihpasqeprwfdwvddMHDWCISRQLWWGHRIPIWYGPNGEVVCVG--------PDDEVPT 445
Cdd:COG0495 418 -------------R---------------------LRDWLISRQRYWGEPIPIIHCEDCGVVPVPedqlpvelPEDVDFD 463
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 446 GEG---------W--TQDP----------DVLDTWF-SSalwpfstmgW-------PDAT-----PELEKfYPTSVlvtg 491
Cdd:COG0495 464 PTGgsplarapeWvnVTCPkcggparretDTMDTFVdSS---------WyylrytdPHNDeapfdPEAAN-YWLPV---- 529
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 492 yD---------IL------FFWvaRMMmfstFAATLADSPlgkgrdgrpqVPFKDVFLHGLVRD--EQGR------KMSK 548
Cdd:COG0495 530 -DqyiggiehaILhllyarFFT--KVL----RDLGLVSFD----------EPFKRLLTQGMVLEvgKDGVviggieKMSK 592
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 549 SLGNGIDPLDWVRDYGADALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFNatrfaLMNGAHVGELPDRDQLTDTDRW 628
Cdd:COG0495 593 SKGNVVDPDEIIEKYGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVWR-----LVVDEAEALKLDVADLSEADKE 667
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 629 ILDRLEQVRAEVDAALDKYEFSKANEALYHFawdevcdwylemtkvdfprLNDGETMTEEQAARAASTRlvlgRVLDTLL 708
Cdd:COG0495 668 LRRALHKTIKKVTEDIERLRFNTAIAALMEL-------------------VNALYKAKDSGEADRAVLR----EALETLV 724
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|.
gi 1092670728 709 RLLHPSMPFVTETLWKALtdgaeGFEDSLVISAWPdatmTADGAAV--DEV 757
Cdd:COG0495 725 LLLAPFAPHIAEELWERL-----GHEGSVADAPWP----EADEAALveDEV 766
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
54-584 |
1.97e-45 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 166.64 E-value: 1.97e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 54 PPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWEWKHD 133
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 134 YGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRMVNWsPVLQTAisdievkyedaegelvsf 213
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-PLIYRA------------------ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 214 rygdgedsivvattrvetmlgdvaiavhpederythlvgkvldhpfredlkiqviaddyvdrefgtgavkiTPahdpndf 293
Cdd:cd00818 150 -----------------------------------------------------------------------TP------- 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 294 amgqrhdldmpevidttgrifntgtrfdgmdraeartaltealreqgrivkeirpyvhsvghsersgepiepllslQWFV 373
Cdd:cd00818 152 ----------------------------------------------------------------------------QWFI 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 374 KVDELAKmsgDAVREGDTV-IHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWYGP-NGEVVCVgpddevptgegwtQ 451
Cdd:cd00818 156 RVTKIKD---RLLEANDKVnWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEdCGEVLVR-------------R 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 452 DPDVLDTWFSSALWPFSTMGWPDATPELEKFYPTSVLVTGYDILFFWvarmmmfstFAATLADSPLGKGRdgrpqVPFKD 531
Cdd:cd00818 220 VPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGW---------FYSLLLLSTALFGK-----APYKN 285
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 1092670728 532 VFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSDLPV 584
Cdd:cd00818 286 VIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
17-726 |
2.75e-40 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 161.29 E-value: 2.75e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 17 SWNPADVESD----LYQGWVDAGYFKADPSSSKPAYSIVLPPPNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGM 92
Cdd:PTZ00427 69 SENPNIVEEEekvlKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 93 DHAGIATQTKVEAMLKESEGKDRFDYGREEFVEKVWEWKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKE 172
Cdd:PTZ00427 149 DCHGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSE 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 173 LFDRGLIYRAKRMVNWSPVLQTAISDIEVK--YEDAE------------------------------GELVSFRYGD--- 217
Cdd:PTZ00427 229 LYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDTPdpsiiisfvlcsdfpkveeecnieedkqllGEKYSVLYNNkre 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 218 ----------------GEDSIVVATTRVETMLGDVAIAV----------HPEDER------------------------- 246
Cdd:PTZ00427 309 nsnngnnnstnnvcyaQHSEILAWTTTPWTLPSNLALCVnehftylrihHVKSNRvvivgecrlewimkelkwnvedlki 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 247 -------------YTHLVGKVLD-HPFREDlKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEV------ 306
Cdd:PTZ00427 389 vnrfkgkelkglrYKPLFTNFYEkYNFKER-AYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVIDPEKnifidp 467
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 307 IDTTGRIFNTGTRFDGMDRAEARTALTEALREQGRIVKEiRPYVHSVGHSERSGEPIEPLLSLQWFVKVdelAKMSGDAV 386
Cdd:PTZ00427 468 LDANGYFTNEVEEVQNLYIKEADNVIKKKLKNENRLLSN-NTIVHSYPFCWRSDTPLIYRAIPAWFIRV---SNSTNELV 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 387 REGDTV--IHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPIWYGPNGE-VVCVGP------------------------ 439
Cdd:PTZ00427 544 KNNETTywIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMEtVICVESikhleelsgvknindlhrhfidhi 623
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 440 DDEVPTGEGW---TQDPDVLDTWFSSALWPFSTMGWP--DATPELEKFYPTSVLVTGYDILFFWVARMMMFSTFaatLAD 514
Cdd:PTZ00427 624 EIKNPKGKTYpklKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTL---LFD 700
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 515 splgkgrdgrpQVPFKDVFLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTL-----ARGANPGSDLPVGNDAA 589
Cdd:PTZ00427 701 -----------KAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLinsvaVRAENLKFQEKGVNEVV 769
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 590 QSsrnFATKLFNATRFALMNGAHVGELPDRDQLTDT----------DRWILDRLEQVRAEVDAALDKYEFSKANEALYHF 659
Cdd:PTZ00427 770 KS---FILPFYHSFRFFSQEVTRYECLNKKQFLFNTdyiykndnimDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQF 846
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 660 AwDEVCDWYLemtkvdfpRLNDGE---TMTEEQAARAASTrlvLGRVLDTLLRLLHPSMPFVTETLWKAL 726
Cdd:PTZ00427 847 I-ENLTNWYI--------RLNRDRmrgSLGEENCLQSLCT---TYRTLHLFTVLMAPFTPFITEYIYQQL 904
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
61-745 |
4.19e-37 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 150.79 E-value: 4.19e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 61 LHMGHALDHTLMDALVRRKRMQGYEVLWlPGMDHAgiaTQTKVEAM---LKESEGK--DRF-DYGR--EEFVEKV---WE 129
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PMAFHV---TGTPILGIaerIARGDPEtiELYkSLYGipEEELEKFkdpEY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 130 WKHDYGGRIGNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRMVNWSPVLQTAISDIEVKY-EDAE- 207
Cdd:PRK12300 77 IVEYFSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDgEEPEi 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 208 GELVSFRYGDGEDSI-VVATTRVETMLGDVAIAVHPE---------DERY-------------------------THLVG 252
Cdd:PRK12300 157 VEYTLIKFEESEDLIlPAATLRPETIFGVTNLWVNPDatyvkaevdGEKWivskeaaeklsfqdrdveiieeikgSELIG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 253 KVLDHPFREDlKIQVIADDYVDREFGTGAVKITPAHDPNDFA-------------------------------------M 295
Cdd:PRK12300 237 KKVKNPVTGK-EVPILPADFVDPDNGTGVVMSVPAHAPYDYValrdlkknkelldviepiplievegygefpakevvekL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 296 GQRHDLDmPEVIDTTGRI----FNTG------TRFDGMDRAEARTALTEALREQG--RIVKEI--RPYVHsvghseRSGE 361
Cdd:PRK12300 316 GIKSQED-PELEEATKEVyraeFHKGvlkentGEYAGKPVREAREKITKDLIEKGiaDIMYEFsnRPVYC------RCGT 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 362 PIEP-LLSLQWFVKVD-----ELAKMSGDAVRegdtvIHPASQEPRWFDWVDDMHDWCISRQLWWGHRIPiWygpngevv 435
Cdd:PRK12300 389 ECVVkVVKDQWFIDYSdpewkELAHKALDNME-----IIPEEYRKEFENTIDWLKDRACARRRGLGTRLP-W-------- 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 436 cvgpDDE----------------------VPTGEGWTQ-DPDVLDTWF---SSALWPFSTMGWPDAT-----PELEKFYP 484
Cdd:PRK12300 455 ----DEEwiieslsdstiymayytiahkiREYGIKPEQlTPEFFDYVFlgkGDPEEVSKKTGIPKEIleemrEEFLYWYP 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 485 TSVLVTGYD-----ILFFwvarmmMFSTFAATladsplgkGRDGRPqvpfKDVFLHGLVRDEqGRKMSKSLGNGIDPLDW 559
Cdd:PRK12300 531 VDWRHSGKDlipnhLTFF------IFNHVAIF--------PEEKWP----RGIVVNGFVLLE-GKKMSKSKGNVIPLRKA 591
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 560 VRDYGADALRFTLARGANPGSDLPVGNDAAQSSRNFATKLFN-ATRFALMNGahvgelpdRDQLTDTDRWILDRLEQVRA 638
Cdd:PRK12300 592 IEEYGADVVRLYLTSSAELLQDADWREKEVESVRRQLERFYElAKELIEIGG--------EEELRFIDKWLLSRLNRIIK 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 639 EVDAALDKYEFSKA-NEALYHFawDEVCDWYLEMTKvdfprlndgetmteeqaaraASTRLVLGRVLDTLLRLLHPSMPF 717
Cdd:PRK12300 664 ETTEAMESFQTRDAvQEAFYEL--LNDLRWYLRRVG--------------------EANNKVLREVLEIWIRLLAPFTPH 721
|
810 820
....*....|....*....|....*...
gi 1092670728 718 VTETLWKALtdGAEGFedsLVISAWPDA 745
Cdd:PRK12300 722 LAEELWHKL--GGEGF---VSLEKWPEP 744
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
626-789 |
8.57e-36 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 132.14 E-value: 8.57e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 626 DRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKvdfPRLNDGETMTEEQAaraastrlVLGRVLD 705
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIK---DRLYGEEPDSRAQT--------TLYEVLE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 706 TLLRLLHPSMPFVTETLWKaltdgaegfEDSLVISAWPDatmtaDGAAVDEVAARRIADAQKLVTELRRFRNDQGVKPSQ 785
Cdd:pfam08264 70 TLLRLLAPFMPFITEELWQ---------KESIHLAPWPE-----DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSL 135
|
....
gi 1092670728 786 RVPA 789
Cdd:pfam08264 136 PLEV 139
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
52-743 |
1.31e-32 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 133.70 E-value: 1.31e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 52 LPPPNvtGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMD-HagiatQTKVeaMLK-ESEGKDRfdygrEEFVEKVWE 129
Cdd:COG0143 9 IPYAN--GPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeH-----GTKI--ELAaEKEGITP-----QELVDRIHA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 130 -WKHDYGG-RIGNqmrqigDslDWSRerfTLDEGLSRAVQTIFKELFDRGLIYRakrmvnwspvlqtaiSDIEVKYEdae 207
Cdd:COG0143 75 eFKELFEKlGISF------D--NFIR---TTSPEHKELVQEIFQRLYDNGDIYK---------------GEYEGWYC--- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 208 gelvsfrygdgedsivvattrvetmlgdvaiavhPEDERYthlvgkvldhpfredlkiqvIADDYVDrefGTGavkitpa 287
Cdd:COG0143 126 ----------------------------------PECERF--------------------LPDRYVE---GTC------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 288 hdPNDFAMGQRHDLdmpevidttgrIFNTGTRFDGMDRAEARTALtealreqgrivkeirpyvhsvghserSGEPIEPLL 367
Cdd:COG0143 142 --PKCGAEDAYGDQ-----------CENCGATLEPTELINPRSAI--------------------------SGAPPELRE 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 368 SLQWFVKVDELAKMSGDAVREgdtviHPASQEPR------WFDwvDDMHDWCISRQLWWGhrIPIwygpngevvcvgPDD 441
Cdd:COG0143 183 EEHYFFRLSKYQDRLLEWIEE-----NPDIQPEVrnevlsWLK--EGLQDLSISRDFDWG--IPV------------PGD 241
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 442 E-----V----PTG-----EGWTQDPDVLDTWfssalWPFstmgWPDATPELekfyptsVLVTGYDILFF----WVArMM 503
Cdd:COG0143 242 PgkvfyVwfdaLIGyisatKGYADDRGLPEDF-----EKY----WPAPDTEL-------VHFIGKDIIRFhaiiWPA-ML 304
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 504 MFSTFaatladsplgkgrdgrpQVPfKDVFLHGLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSDL- 582
Cdd:COG0143 305 MAAGL-----------------PLP-KKVFAHGFLTVE-GEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGd 365
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 583 ----------------PVGNdAAQSSRNFATKLFNatrfalmngahvGELPDRDQLTDTDRWILDRLEQVRAEVDAALDK 646
Cdd:COG0143 366 fswedfvarvnsdlanDLGN-LASRTLSMIHKYFD------------GKVPEPGELTEADEELLAEAEAALEEVAEAMEA 432
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 647 YEFSKANEALYHFA------WDEVCDWylemtkvdfprlndgETMTEEQAARAASTRLVLGRVLDTLLRLLHPSMPFVTE 720
Cdd:COG0143 433 FEFRKALEEIMALAraankyIDETAPW---------------KLAKDEDPERLATVLYTLLEALRILAILLKPFLPETAE 497
|
730 740
....*....|....*....|...
gi 1092670728 721 TLWKALtdGAEGFEDSLVISAWP 743
Cdd:COG0143 498 KILEQL--GLEGDELTWEDAGWP 518
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
21-791 |
1.29e-30 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 129.94 E-value: 1.29e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 21 ADVESDLYQGWVDAGYFKA--DPSSSKPAYSIV--LPPPNVTGqLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAG 96
Cdd:PLN02563 83 HEIEPKWQRYWEENRTFRTpdDVDTSKPKFYVLdmFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 97 I-----ATQTKVEAMLKESEGKDRFDygreefvekvwewkhdyggrigNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFK 171
Cdd:PLN02563 162 LpaeqyAIETGTHPKITTLKNIARFR----------------------SQLKSLGFSYDWDREISTTEPEYYKWTQWIFL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 172 ELFDRGLIYRAKRMVNWSPVLQTAISDIEV-------------------------KYED--------------------- 205
Cdd:PLN02563 220 QLLKRGLAYQAEVPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYADrlledlddldwpesikemqrn 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 206 ----AEGELVSFRYGDG-----EDSIVVATTRVETMLGDVAIAVHPED---------------ERYTHLVGKVLD----- 256
Cdd:PLN02563 300 wigrSEGAELDFSVLDGegkerDEKITVYTTRPDTLFGATYLVVAPEHpllsslttaeqkeavEEYVDAASRKSDlerte 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 257 ---------------HPFREDlKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVIDTT----------- 310
Cdd:PLN02563 380 lqkektgvftgsyaiNPATGE-AIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPAdgneddaekay 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 311 ---GRIFN---TGTRFDGMDRAEARTALTEALREQGrivkeirpyvhsvghserSGEPiepllslqwfvKVDElakmsgd 384
Cdd:PLN02563 459 tgeGVIVNsssSGLDINGLSSKEAAKKVIEWLEETG------------------NGKK-----------KVNY------- 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 385 avregdtvihpasqeprwfdwvdDMHDWCISRQLWWGHRIPIWYGPN-GEVVCVgPDDEVP-------------TGEG-W 449
Cdd:PLN02563 503 -----------------------KLRDWLFARQRYWGEPIPVVFLEDsGEPVPV-PESDLPltlpelddftptgTGEPpL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 450 TQDPDVLDTWFSSALWPF----STM-GW---------------PDA--TPELEKFY-PTSVLVTGYD-----ILF--FW- 498
Cdd:PLN02563 559 AKAVSWVNTVDPSSGKPArretNTMpQWagscwyylrfmdpknSNAlvDKEKEKYWmPVDLYVGGAEhavlhLLYarFWh 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 499 ------------------VARMMMFSTFAATL----------ADSPLGKGRDGRPQVPFKDVFLHG----LVRDEQGR-- 544
Cdd:PLN02563 639 kvlydigvvstkepfqclVNQGMILGEVEYTAfkdsdgeyvsADTADRLGELQQEKIPEEKVIKSGdsfvLKDDPSIRli 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 545 ----KMSKSLGNGIDPLDWVRDYGADALR-FTLARGanPGSDLPVGNDAA-QSSRNFATKLFNATRFALMNGahvGELPD 618
Cdd:PLN02563 719 arahKMSKSRGNVVNPDDVVSEYGADSLRlYEMFMG--PLRDSKTWSTSGvEGVHRFLGRTWRLVVGAPLPD---GSFRD 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 619 RDQLTDT--DRWILDRLEQVRAEVDAALDKYEFSKANEALYHF-----AWDEVcdwylemtkvdfPRlndgetmteeqaa 691
Cdd:PLN02563 794 GTVVTDEepSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFtnaayKWDKV------------PR------------- 848
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 692 raastrlvlgRVLDTLLRLLHPSMPFVTETLWKALtdgaeGFEDSLVISAWPDA----------------------TMTA 749
Cdd:PLN02563 849 ----------EAIEPFVLLLSPYAPHLAEELWFRL-----GHSNSLAYEPWPEAnpsylvddtvvlpvqingktrgTIEV 913
|
970 980 990 1000
....*....|....*....|....*....|....*....|..
gi 1092670728 750 DGAAVDEVAARRIADAQKlvteLRRFRNDQGVKPSQRVPARM 791
Cdd:PLN02563 914 EEGCSEDDAFALASQDEK----LSKYLDGKEIKKRIYVPGKI 951
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
410-726 |
1.46e-23 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 105.73 E-value: 1.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 410 HDWCISRQ-LWWGhrIPIwygpngevvcvgPDDevptgegwtqDPDVLDTWFSsALWPF-STMGWPDATPELE----KFY 483
Cdd:PRK11893 199 KDLSISRTnFDWG--IPV------------PGD----------PKHVIYVWFD-ALTNYlTALGYPDDEELLAelfnKYW 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 484 PTSVLVTGYDILFF----WVArMMMfstfaatLADSPLgkgrdgrpqvpFKDVFLHG-LVRDeqGRKMSKSLGNGIDPLD 558
Cdd:PRK11893 254 PADVHLIGKDILRFhavyWPA-FLM-------AAGLPL-----------PKRVFAHGfLTLD--GEKMSKSLGNVIDPFD 312
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 559 WVRDYGADALRFTLARganpgsDLPVGNDaaqssRNFATKLFNATRFA-LMN--GAHV------------GELPDRDQLT 623
Cdd:PRK11893 313 LVDEYGVDAVRYFLLR------EIPFGQD-----GDFSREAFINRINAdLANdlGNLAqrtlsmiaknfdGKVPEPGALT 381
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 624 DTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAwdEVCDWYLEMTKVDFPRLNDGETMTEeqaaraastrlVLGRV 703
Cdd:PRK11893 382 EADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQAPWSLAKTDPERLAT-----------VLYTL 448
|
330 340
....*....|....*....|....*.
gi 1092670728 704 LDTLLR---LLHPSMPFVTETLWKAL 726
Cdd:PRK11893 449 LEVLRGiavLLQPVMPELAAKILDQL 474
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
468-754 |
1.51e-23 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 106.42 E-value: 1.51e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 468 STMGWPDATPEL-EKFYPTSVLVTGYDIL-F---FWVARMMMfstfaatlADSPLgkgrdgrpqvpFKDVFLHG-LVRDe 541
Cdd:PRK12267 237 TALGYGSDDDELfKKFWPADVHLVGKDILrFhaiYWPIMLMA--------LGLPL-----------PKKVFAHGwWLMK- 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 542 qGRKMSKSLGNGIDPLDWVRDYGADALRFTLARganpgsDLPVGNDAAQSSRNFATK-----------LFNATRfALMNG 610
Cdd:PRK12267 297 -DGKMSKSKGNVVDPEELVDRYGLDALRYYLLR------EVPFGSDGDFSPEALVERinsdlandlgnLLNRTV-AMINK 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 611 AHVGELPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALyhfawdevcdWYLemtkvdFPRLN---DgETM-- 685
Cdd:PRK12267 369 YFDGEIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEV----------WKL------ISRANkyiD-ETApw 431
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1092670728 686 ----TEEQAARAAStrlVLGRVLDTLLR---LLHPSMPFVTETLWKAL--TDGAEGFEDSLVISAWPDATMTADGAAV 754
Cdd:PRK12267 432 vlakDEGKKERLAT---VMYHLAESLRKvavLLSPFMPETSKKIFEQLglEEELTSWESLLEWGGLPAGTKVAKGEPL 506
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
593-769 |
1.94e-21 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 92.61 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 593 RNFATKLFNATRFALM-----NGAHVGELPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFaWDEVCDW 667
Cdd:cd07961 11 RKVLLPLWNAYRFFVTyanldGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELTNW 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 668 YLemtkvdfpRLND----GETMTEEQAArAASTrlvLGRVLDTLLRLLHPSMPFVTETLWKALTDGAEGFEDSLVISAWP 743
Cdd:cd07961 90 YI--------RRNRkrfwGEEGDDDKLA-AYAT---LYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWP 157
|
170 180
....*....|....*....|....*.
gi 1092670728 744 datmTADGAAVDEVAARRIADAQKLV 769
Cdd:cd07961 158 ----EVDESLIDEELEEAMELVREIV 179
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
844-908 |
1.83e-19 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 83.09 E-value: 1.83e-19
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1092670728 844 DVAAERKRLEKDLAKAEKELAGTEKKLGNEAFLSKAPEQVVEKIKTRHQFALEEIDRIKARLEGL 908
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKL 65
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
53-188 |
1.06e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 81.91 E-value: 1.06e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 53 PPPNvtGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDhagiATQTKVEAMlKESEGKDRFDYgREEFVEKvweWKh 132
Cdd:cd00812 9 PYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAENA-AIKIGRDPEDW-TEYNIKK---MK- 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1092670728 133 dyggrigNQMRQIGDSLDWSRERFTLDEGLSRAVQTIFKELFDRGLIYRAKRMVNW 188
Cdd:cd00812 77 -------EQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
55-582 |
7.26e-16 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 80.41 E-value: 7.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 55 PNVTGQLHMGHALDHTLMDALVRRKRMQGYEVLWLPGMDHAGIATQTKVEAmlkesEGKDrfdygREEFVEKVWE-WKHD 133
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK-----EGIT-----PEELVDRYHEiHRED 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 134 YggrignqmrqigDSLDWSRERF--TLDEGLSRAVQTIFKELFDRGLIYRAkrmvnwspvlqtaisDIEVKYEdaegelv 211
Cdd:pfam09334 78 F------------KKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEK---------------EIEQFYC------- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 212 sfrygdgedsivvattrvetmlgdvaiavhPEDERYthlvgkvldhpfredlkiqvIADDYVDrefGTGavkitpahdPN 291
Cdd:pfam09334 124 ------------------------------PSDERF--------------------LPDRYVE---GTC---------PH 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 292 DFAMGQRHDldmpevidttgRIFNTGTRFDGMDRAEARTALtealreqgrivkeirpyvhsvghserSGEPIEPLLSLQW 371
Cdd:pfam09334 142 CGSEDARGD-----------QCENCGRHLEPTELINPKCVI--------------------------CGTTPEVKETEHY 184
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 372 FVKVDELAKMSGDAVREGDT-----VIHPASQeprWFDwvDDMHDWCISRQLWWGHRIPiwyGPNGEVVCVGPDdeVPTG 446
Cdd:pfam09334 185 FFDLSKFQDKLREWIEENNPewpenVKNMVLE---WLK--EGLKDRAISRDLDWGIPVP---GAEGKVFYVWLD--APIG 254
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 447 -----EGWTQDPDVLDTWfssalWPfstmgwpdATPELEKFYptsvlVTGYDILFF----WVArMMMfstfaatladspl 517
Cdd:pfam09334 255 yisatKELSGNEEKWKEW-----WP--------NDPDTELVH-----FIGKDIIYFhtifWPA-MLL------------- 302
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1092670728 518 gkgrDGRPQVPfKDVFLHGLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSDL 582
Cdd:pfam09334 303 ----GAGYRLP-TTVFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDT 361
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
616-756 |
1.13e-15 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 76.02 E-value: 1.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 616 LPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEVCDWYLEMTKvDfpRL-----NDgetmteeQA 690
Cdd:cd07960 36 AVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIK-D--RLycdakDS-------LE 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092670728 691 ARAASTrlVLGRVLDTLLRLLHPSMPFVTETLWKALtdGAEGFEDSLVISAWPDATMTADGAAVDE 756
Cdd:cd07960 106 RRSAQT--VLYHILDALLKLLAPILPFTAEEVWEHL--PGEKKEESVFLEDWPELPEEWKDEELEE 167
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
402-736 |
8.58e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 75.57 E-value: 8.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 402 WFDwvDDMHDWCISRQL-WWGHRIPiwyGPNGEVVCVGPDdeVPTG-----EGWTQDPDVLDtWfsSALWPfstmgwPDA 475
Cdd:PRK00133 219 WLE--EGLQDWDISRDApYFGFEIP---GAPGKVFYVWLD--APIGyisstKNLCDKRGGLD-W--DEYWK------KDS 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 476 TPELEKFyptsvlvTGYDILF----FWVArMMMFSTFaaTLADSplgkgrdgrpqvpfkdVFLHGLVRDEqGRKMSKSLG 551
Cdd:PRK00133 283 DTELYHF-------IGKDIIYfhtlFWPA-MLEGAGY--RLPTN----------------VFAHGFLTVE-GAKMSKSRG 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 552 NGIDPLDWVRDYGADALRFTLARGANPG----------------SDL--PVGNDAaqsSRN--FATKLFNatrfalmnga 611
Cdd:PRK00133 336 TFIWARTYLDHLDPDYLRYYLAAKLPETiddldfnwedfqqrvnSELvgKVVNFA---SRTagFINKRFD---------- 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 612 hvGELPDrdqlTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFA------WDEVCDWylEMTKVDfprlndgetm 685
Cdd:PRK00133 403 --GKLPD----ALADPELLEEFEAAAEKIAEAYEAREFRKALREIMALAdfankyVDDNEPW--KLAKQD---------- 464
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1092670728 686 tEEQAARAASTRLVLGRVLDTLLrllHPSMPFVTETLWKALTDGAEGFEDS 736
Cdd:PRK00133 465 -GERLQAVCSVGLNLFRALAIYL---KPVLPELAERAEAFLNLEELTWDDA 511
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
371-581 |
2.12e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 66.02 E-value: 2.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 371 WFVKVDELAKMSGDAVREGDTVIHPAS--QEPRwfDWVDD-MHDWCISRQLW-WGhrIPIwygPNGE--VVCVGPDDEV- 443
Cdd:cd00814 140 YFFRLSKFQDRLLEWLEKNPDFIWPENarNEVL--SWLKEgLKDLSITRDLFdWG--IPV---PLDPgkVIYVWFDALIg 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 444 ---PTGEGWTQDPDvlDTWFSSalwpfstmGWPDAtpelekfyptsVLVTGYDILFF----WVArMMMfstfaatLADSP 516
Cdd:cd00814 213 yisATGYYNEEWGN--SWWWKD--------GWPEL-----------VHFIGKDIIRFhaiyWPA-MLL-------GAGLP 263
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1092670728 517 LgkgrdgrpqvpFKDVFLHGLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGANPGSD 581
Cdd:cd00814 264 L-----------PTRIVAHGYLTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
622-726 |
2.40e-10 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 58.76 E-value: 2.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 622 LTDTDRWILDRLEQVRAEVDAALDKYEFSKA-NEALYHFawDEVCDWYLEMTkvdfprlndGETMTEEqaaraastrlVL 700
Cdd:cd07959 33 LTFIDRWLLSRLNRLIKETTEAYENMQFREAlKEGLYEL--QNDLDWYRERG---------GAGMNKD----------LL 91
|
90 100
....*....|....*....|....*.
gi 1092670728 701 GRVLDTLLRLLHPSMPFVTETLWKAL 726
Cdd:cd07959 92 RRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
590-713 |
3.26e-10 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 58.29 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 590 QSSRNFATKLFNATRFALMNGAHVGELPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDEvcDWYL 669
Cdd:cd07375 5 KQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL--NWYL 82
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1092670728 670 EMTKVDFPRLNDgetmteeqaarAASTRLVLGRVLDTLLRLLHP 713
Cdd:cd07375 83 DELKPALQTEEL-----------REAVLAVLRAALVVLTKLLAP 115
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
207-336 |
4.66e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 56.79 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 207 EGELVSFRYGDGEDSIVVATTRVETMLGD--VAIAV-HP-------EDERYTHLVGKVLD-------------------- 256
Cdd:pfam13603 8 EGAEITFPVEGTDEKIEVFTTRPDTLMGVtfVALAPeHPlveklaeKNPEVAAFIEECKNtseiertsetkekegvftgl 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 257 ---HPFREDlKIQVIADDYVDREFGTGAVKITPAHDPNDFAMGQRHDLDMPEVI----------------DTTGRIFNTG 317
Cdd:pfam13603 88 yaiHPITGE-KIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIqpedgdldldimteayTEEGILVNSG 166
|
170
....*....|....*....
gi 1092670728 318 tRFDGMDRAEARTALTEAL 336
Cdd:pfam13603 167 -EFDGLDSEEAKEAIIKKL 184
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
371-602 |
3.97e-08 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 57.03 E-value: 3.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 371 WFVKVDELAKMSGDAVREGDTVIHPASQEPRWFDWVDD-MHDWCISRQLW-WGhrIPIwygpngevvcvgPDDevptgeg 448
Cdd:PLN02224 226 YFFALSKYQKPLEDILAQNPRFVQPSYRLNEVQSWIKSgLRDFSISRALVdWG--IPV------------PDD------- 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 449 wtqDPDVLDTWFSSALWPFSTMGWPDATPELEKF----YPTSVLVTGYDILFF----WVARMMmfstfAATLadsplgkg 520
Cdd:PLN02224 285 ---DKQTIYVWFDALLGYISALTEDNKQQNLETAvsfgWPASLHLIGKDILRFhavyWPAMLM-----SAGL-------- 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 521 rdgrpQVPfKDVFLHGLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTLARganpgsDLPVGNDAAQSSRNFaTKLF 600
Cdd:PLN02224 349 -----ELP-KMVFGHGFLTKD-GMKMGKSLGNTLEPFELVQKFGPDAVRYFFLR------EVEFGNDGDYSEDRF-IKIV 414
|
..
gi 1092670728 601 NA 602
Cdd:PLN02224 415 NA 416
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
614-726 |
2.57e-06 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 47.48 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 614 GELPDRDQLTDTDRWILDRLEQVRAEVDAALDKYEFSKANEALYHFAWDevCDWYLEMTKvdfprlnDGETMTEEQAARA 693
Cdd:cd07957 26 GVVPEFGGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARA--ANKYIDETA-------PWKLAKEEDPERL 96
|
90 100 110
....*....|....*....|....*....|....*..
gi 1092670728 694 AStrlVLGRVLDtLLR----LLHPSMPFVTETLWKAL 726
Cdd:cd07957 97 AT---VLYVLLE-LLRilaiLLSPFMPETAEKILDQL 129
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
528-645 |
9.52e-05 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 45.86 E-value: 9.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092670728 528 PFKDVFLH-GLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTLARgANPGSDLPVGNDAAQSSRNFATKLFNATRFA 606
Cdd:COG0215 248 PFARYWMHnGFLTVN-GEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLS-AHYRSPLDFSEEALEEAEKALERLYNALRRL 325
|
90 100 110
....*....|....*....|....*....|....*....
gi 1092670728 607 lmngahvgelpdrDQLTDTDRWILDRLEQVRAEVDAALD 645
Cdd:COG0215 326 -------------EEALGAADSSAEEIEELREEFIAAMD 351
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
528-572 |
9.27e-04 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 41.41 E-value: 9.27e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1092670728 528 PFKDVFLH-GLVRDEqGRKMSKSLGNGIDPLDWVRDYGADALRFTL 572
Cdd:cd00672 157 PFARYWLHtGHLTID-GEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
522-574 |
1.13e-03 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 42.49 E-value: 1.13e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1092670728 522 DGRPQVPFKdvflHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLAR 574
Cdd:COG1384 268 GGEPPEGFV----YELFLDENGEKISKSKGNGLTVEEWLEYAEPESLRYFMFR 316
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
522-580 |
3.21e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 40.71 E-value: 3.21e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1092670728 522 DGRPQVPFkdvfLHGLVRDEQGRKMSKSLGNGIDPLDWVRDYGADALRFTLARGaNPGS 580
Cdd:pfam01921 260 GGEPPEGF----PYELILLKGGGKMSSSKGNVITPEDWLEYAPPESLRFLMFRT-KPKK 313
|
|
| |
