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Conserved domains on  [gi|1092698151|ref|WP_070629662|]
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MULTISPECIES: type II toxin-antitoxin system HicB family antitoxin [Rothia]

Protein Classification

type II toxin-antitoxin system HicB family antitoxin( domain architecture ID 10790599)

type II toxin-antitoxin system HicB family antitoxin is the antitoxin component of a type II toxin-antitoxin (TA) system and functions as an mRNA interferase antitoxin preventing effects of the cognate HicA family toxin

Gene Ontology:  GO:0110001
PubMed:  28279904|16895922|30337369
SCOP:  4001747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
11-111 1.22e-39

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


:

Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 127.61  E-value: 1.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092698151  11 YTYRVEWSEDDQEFVGTVAEFP-SLSYLAPTSTEAFAGIREVVADTLEILEEDGREaPEpfslRSFSGRFNLRVSPQLHR 89
Cdd:COG4226     8 YTASVEYSPEDGEFVGKVLGIPdLISFEGESVEELEKAFREAVDDYLEDCKELGEE-PE----KPYSGKFNVRIPPELHR 82

                          90       100
                  ....*....|....*....|..
gi 1092698151  90 RLVQQAALSHQSLNQYVSQQLE 111
Cdd:COG4226    83 ALAIAAAEEGVSLNQWVVEALS 104
 
Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
11-111 1.22e-39

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 127.61  E-value: 1.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092698151  11 YTYRVEWSEDDQEFVGTVAEFP-SLSYLAPTSTEAFAGIREVVADTLEILEEDGREaPEpfslRSFSGRFNLRVSPQLHR 89
Cdd:COG4226     8 YTASVEYSPEDGEFVGKVLGIPdLISFEGESVEELEKAFREAVDDYLEDCKELGEE-PE----KPYSGKFNVRIPPELHR 82

                          90       100
                  ....*....|....*....|..
gi 1092698151  90 RLVQQAALSHQSLNQYVSQQLE 111
Cdd:COG4226    83 ALAIAAAEEGVSLNQWVVEALS 104
HicB pfam05534
HicB family; This family consists of several bacterial HicB related proteins. The function of ...
 59-110 1.92e-12

HicB family; This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.


Pssm-ID: 310261  Cd Length: 51  Bit Score: 56.91  E-value: 1.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1092698151  59 LEEDGREAPEPFslRSFSGRFNLRVSPQLHRRLVQQAALSHQSLNQYVSQQL 110
Cdd:pfam05534   2 LETCKELGIEPE--KPYSGKFNLRISPELHARLALAAAEQGVSLNQFVEQAL 51
 
Name Accession Description Interval E-value
HicB COG4226
Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];
11-111 1.22e-39

Predicted nuclease of the RNAse H fold, HicB family [General function prediction only];


Pssm-ID: 443370 [Multi-domain]  Cd Length: 110  Bit Score: 127.61  E-value: 1.22e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092698151  11 YTYRVEWSEDDQEFVGTVAEFP-SLSYLAPTSTEAFAGIREVVADTLEILEEDGREaPEpfslRSFSGRFNLRVSPQLHR 89
Cdd:COG4226     8 YTASVEYSPEDGEFVGKVLGIPdLISFEGESVEELEKAFREAVDDYLEDCKELGEE-PE----KPYSGKFNVRIPPELHR 82

                          90       100
                  ....*....|....*....|..
gi 1092698151  90 RLVQQAALSHQSLNQYVSQQLE 111
Cdd:COG4226    83 ALAIAAAEEGVSLNQWVVEALS 104
HicB pfam05534
HicB family; This family consists of several bacterial HicB related proteins. The function of ...
 59-110 1.92e-12

HicB family; This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches.


Pssm-ID: 310261  Cd Length: 51  Bit Score: 56.91  E-value: 1.92e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1092698151  59 LEEDGREAPEPFslRSFSGRFNLRVSPQLHRRLVQQAALSHQSLNQYVSQQL 110
Cdd:pfam05534   2 LETCKELGIEPE--KPYSGKFNLRISPELHARLALAAAEQGVSLNQFVEQAL 51
HicB COG1598
Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];
12-73 2.30e-06

Antitoxin component HicB of the HicAB toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441206  Cd Length: 65  Bit Score: 41.79  E-value: 2.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092698151  12 TYRVE-WSEDDQEFVGTVAEFPSLSYLAPTSTEAFAGIREVVADTLEILEEDGREAPEPFSLR 73
Cdd:COG1598     1 KYPAIiEKDEDGGYVAEVPDLPGCVTQGDTLEEALENAKEALELHLEALLEDGEPIPEPSSIE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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