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Conserved domains on  [gi|1092854807|ref|WP_070767341|]
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MULTISPECIES: metal-dependent transcriptional regulator [Corynebacterium]

Protein Classification

metal-dependent transcriptional regulator( domain architecture ID 14302172)

metal-dependent transcriptional regulator similar to similar to Corynebacterium diphtheriae diphtheria toxin repressor (DtxR), a metal ion-activated transcriptional regulator that has been linked to virulence and may serve as a global regulator of gene expression

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-135 2.00e-56

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


:

Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 175.78  E-value: 2.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   1 MRDLVDTTEMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHR 80
Cdd:COG1321     1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1092854807  81 LAERLLTDVIGLEWDKVHDEACRWEHVMSDEVERKLLDVLDSYTRSPFGNPIPGL 135
Cdd:COG1321    81 LLERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
DtxR super family cl40295
Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria ...
 152-223 3.06e-14

Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria toxin repressor (DtxR) proteins. DtxR) from Corynebacterium diphtheriae regulates the expression of the gene on corynebacteriophages that encodes diphtheria toxin (DT). Other genes regulated by DtxR include those that encode proteins involved in siderophore-mediated iron uptake.


The actual alignment was detected with superfamily member pfam18357:

Pssm-ID: 436434  Cd Length: 78  Bit Score: 65.40  E-value: 3.06e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092854807 152 RLSDLNPGEYT-IEIVQINEILQVEQSYMKRLHKAGIMPGTEALAEVAAGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:pfam18357   4 RAIDLPEGEPVrVRIVQINEILQVDAEQFRALTDAGITVGAEVTVVNHNGHVRLTHNGKTVELVDDLAHAIRV 76
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-135 2.00e-56

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 175.78  E-value: 2.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   1 MRDLVDTTEMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHR 80
Cdd:COG1321     1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1092854807  81 LAERLLTDVIGLEWDKVHDEACRWEHVMSDEVERKLLDVLDSYTRSPFGNPIPGL 135
Cdd:COG1321    81 LLERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 27-121 5.94e-37

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 124.64  E-value: 5.94e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   27 RARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHRLAERLLTDVIGLEWDKVHDEACRWEH 106
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 1092854807  107 VMSDEVERKLLDVLD 121
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 66-133 2.15e-29

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 104.48  E-value: 2.15e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1092854807  66 DEGRRLATAVMRKHRLAERLLTDVIGLEWDKVHDEACRWEHVMSDEVERKLLDVLDSYTRSPFGNPIP 133
Cdd:pfam02742   2 EKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
DtxR pfam18357
Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria ...
 152-223 3.06e-14

Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria toxin repressor (DtxR) proteins. DtxR) from Corynebacterium diphtheriae regulates the expression of the gene on corynebacteriophages that encodes diphtheria toxin (DT). Other genes regulated by DtxR include those that encode proteins involved in siderophore-mediated iron uptake.


Pssm-ID: 436434  Cd Length: 78  Bit Score: 65.40  E-value: 3.06e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092854807 152 RLSDLNPGEYT-IEIVQINEILQVEQSYMKRLHKAGIMPGTEALAEVAAGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:pfam18357   4 RAIDLPEGEPVrVRIVQINEILQVDAEQFRALTDAGITVGAEVTVVNHNGHVRLTHNGKTVELVDDLAHAIRV 76
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
9-86 5.05e-10

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 56.17  E-value: 5.05e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1092854807   9 EMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHRLAERLL 86
Cdd:PRK11050   36 EDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENFL 113
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 152-223 6.61e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 37.17  E-value: 6.61e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092854807  152 RLSDLNPGEytieIVQINEILQVEQSYMKRLHKAGIMPGTE-ALAEVAAGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:smart00899   2 PLSELKPGE----KARIVRIRDEDPELLRRLLELGLVPGTEvTVLRKAPFGPLVVRVGGELALRREEAEKIFV 70
 
Name Accession Description Interval E-value
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
1-135 2.00e-56

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 175.78  E-value: 2.00e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   1 MRDLVDTTEMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHR 80
Cdd:COG1321     1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1092854807  81 LAERLLTDVIGLEWDKVHDEACRWEHVMSDEVERKLLDVLDSYTRSPFGNPIPGL 135
Cdd:COG1321    81 LLERFLVEVLGVDWDEAHEEAERLEHVLSDETIERLDAFLGFPEEDPHGDPIPDA 135
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 27-121 5.94e-37

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 124.64  E-value: 5.94e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   27 RARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHRLAERLLTDVIGLEWDKVHDEACRWEH 106
Cdd:smart00529   1 TSEIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVDVLGVDEEEVHEEAERLEH 80

                           90
                   ....*....|....*
gi 1092854807  107 VMSDEVERKLLDVLD 121
Cdd:smart00529  81 VLSDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 66-133 2.15e-29

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 104.48  E-value: 2.15e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1092854807  66 DEGRRLATAVMRKHRLAERLLTDVIGLEWDKVHDEACRWEHVMSDEVERKLLDVLDSYTRSPFGNPIP 133
Cdd:pfam02742   2 EKGRKIALRVVRRHRLLERFLVDVLGVDWDEVHEEAERLEHALSDELIDRLDEFLGFPETCPHGDPIP 69
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 6-62 2.24e-16

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 70.48  E-value: 2.24e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1092854807   6 DTTEMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSL 62
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
DtxR pfam18357
Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria ...
 152-223 3.06e-14

Diphteria toxin repressor SH3 domain; This is an SH3 domain which can be found in diphtheria toxin repressor (DtxR) proteins. DtxR) from Corynebacterium diphtheriae regulates the expression of the gene on corynebacteriophages that encodes diphtheria toxin (DT). Other genes regulated by DtxR include those that encode proteins involved in siderophore-mediated iron uptake.


Pssm-ID: 436434  Cd Length: 78  Bit Score: 65.40  E-value: 3.06e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092854807 152 RLSDLNPGEYT-IEIVQINEILQVEQSYMKRLHKAGIMPGTEALAEVAAGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:pfam18357   4 RAIDLPEGEPVrVRIVQINEILQVDAEQFRALTDAGITVGAEVTVVNHNGHVRLTHNGKTVELVDDLAHAIRV 76
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
9-86 5.05e-10

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 56.17  E-value: 5.05e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1092854807   9 EMYLRTIFELEEEGIIPLRARIAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHRLAERLL 86
Cdd:PRK11050   36 EDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGLVEMRPYRGVFLTPEGEKLAQESRERHQIVENFL 113
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
12-93 6.48e-07

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 47.27  E-value: 6.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807  12 LRTIFELEEEGIIPLRArIAERLEQSGPTVSQTVARMERDGLLVVAPD------RSLQLSDEGRRLATAVMRKHRLAERL 85
Cdd:COG1846    41 FRVLAALAEAGGLTQSE-LAERLGLTKSTVSRLLDRLEEKGLVEREPDpedrraVLVRLTEKGRALLEEARPALEALLAE 119


                  ....*...
gi 1092854807  86 LTDVIGLE 93
Cdd:COG1846   120 LLAGLSEE 127
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
10-86 4.31e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 38.34  E-value: 4.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   10 MYLRTIFEleEEGIIPlrARIAERLEQSGPTVSQTVARMERDGLLVVAPDRS------LQLSDEGRRLATAVMRKHRLAE 83
Cdd:smart00347  14 LVLRILYE--EGPLSV--SELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEGRELIEQLLEARSETL 89


                   ...
gi 1092854807   84 RLL 86
Cdd:smart00347  90 AEL 92
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 152-223 6.61e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 37.17  E-value: 6.61e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1092854807  152 RLSDLNPGEytieIVQINEILQVEQSYMKRLHKAGIMPGTE-ALAEVAAGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:smart00899   2 PLSELKPGE----KARIVRIRDEDPELLRRLLELGLVPGTEvTVLRKAPFGPLVVRVGGELALRREEAEKIFV 70
PRK03902 PRK03902
transcriptional regulator MntR;
9-109 7.90e-04

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 38.44  E-value: 7.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1092854807   9 EMYLRTIFEL-EEEGIiplrAR---IAERLEQSGPTVSQTVARMERDGLLVVAPDRSLQLSDEGRRLATAVMRKHRLAER 84
Cdd:PRK03902    7 EDYIEQIYLLiEEKGY----ARvsdIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELLEQ 82

                          90       100
                  ....*....|....*....|....*
gi 1092854807  85 LLTdVIGLEWDKVHDEACRWEHVMS 109
Cdd:PRK03902   83 FLR-IIGVDESKIYNDVEGIEHHLS 106
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 151-223 1.04e-03

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 36.80  E-value: 1.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1092854807 151 RRLSDLNPGEytieIVQINEILQVEQSYMKRLHKAGIMPGTE-ALAEVA--AGRVTLARGDHSLDIPDTLSHAIMV 223
Cdd:pfam04023   1 MPLSELKEGE----TARIVRIRDGDPELLRRLLELGLVPGAEvTVVRKApfGGPIIVRVGGTRIALRREEASKIFV 72
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 6-59 2.32e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 35.26  E-value: 2.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1092854807   6 DTTEMYLRTIFELEEEGIIPLRArIAERLEQSGPTVSQTVARMERDGLLVVAPD 59
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAE-LARRLGISKQTVSRLVKRLEAKGLVEREPS 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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