|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
46-416 |
1.58e-70 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 227.05 E-value: 1.58e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 46 IVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGA 125
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 126 TVWAGtlgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFA 205
Cdd:cd17324 81 AALAP---SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 206 FVAVIGLIAFVSLWFAVPHMNRMPKTRP---MDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIW 282
Cdd:cd17324 158 AIAVLALLAALLLWRLLPSLPPKKPGSLgllSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAII 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 283 IVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAG 362
Cdd:cd17324 238 GLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1093448552 363 RAQTLAAALNQAALNMANAFGAALGGWVIASGyGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17324 318 EARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
45-429 |
5.02e-61 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 203.02 E-value: 5.02e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 45 VIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNg 124
Cdd:PRK10091 4 VILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGN- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 125 atVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAF 204
Cdd:PRK10091 83 --AMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 205 AFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIV 284
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 285 LMAYGIGMVVGTYIGGWLSDRIGEWGIMVA--LVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPnLQTRLMDVAG 362
Cdd:PRK10091 241 MMLVGLGMVLGNLLSGRLSGRYSPLRIAAVtdFIIVLALLMLFFFGGMKTASLIFAFICCAGLFALSAP-LQILLLQNAK 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1093448552 363 RAQTLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAmlaiFIALPTIVLYRRSQAKK 429
Cdd:PRK10091 320 GGELLGAAGGQIAFNLGSAIGAYCGGMMLTLGLAYNYVALPAALLS----FAAMSSLLLYGRYKRQQ 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
41-365 |
3.71e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 154.75 E-value: 3.71e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 41 RRILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFT 120
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 121 IGNGATVWAGtlgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGW 200
Cdd:COG2814 87 LGSLLCALAP---SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 201 RSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVT-PQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSEN 279
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRrPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 280 HIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMD 359
Cdd:COG2814 244 AAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAE 323
|
....*.
gi 1093448552 360 VAGRAQ 365
Cdd:COG2814 324 LAPPEA 329
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
46-429 |
4.62e-32 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 125.77 E-value: 4.62e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 46 IVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGA 125
Cdd:PRK03545 11 VVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 126 TVWAGtlgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFA 205
Cdd:PRK03545 91 SALAW---NFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 206 FVAVIGLIAFVSLWFAVPHMNRMPKT----------RPmdelsALVTPQVLLTVAIgtvgfGGMFAVYTYITWTMTREAG 275
Cdd:PRK03545 168 AIGGGALITLLLLIKLLPLLPSEHSGslkslpllfrRP-----ALVSLYLLTVVVV-----TAHFTAYSYIEPFVQQVAG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 276 MSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQT 355
Cdd:PRK03545 238 LSENFATLLLLLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQV 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093448552 356 RLMDVAGRAQTLAAALNQAALNMANAFGAALGGWVIASgYGYRAPALGGATLAMLAIFIALPTIVLYRRSQAKK 429
Cdd:PRK03545 318 KVLKLAPDATDVAMALFSGIFNIGIGAGALLGNQVSLH-LGLSSIGYVGAALALAALVWSILIFRRFPVTLEEQ 390
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
49-363 |
2.82e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 2.82e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGVTEFVAMGLLP-YIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATV 127
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 128 WAGtlgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFV 207
Cdd:pfam07690 81 FAS---SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 208 AVIGLIAFVSLWFAVPHMNRMPKT-------RPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITwTMTREAGMSENH 280
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKpaeearlSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 281 IWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTIN---FLLIGLLGSVLVPNLQTRL 357
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLllaLLLLGFGFGLVFPALNALV 316
|
....*.
gi 1093448552 358 MDVAGR 363
Cdd:pfam07690 317 SDLAPK 322
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
49-416 |
4.15e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 4.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVW 128
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 129 AGTlgsFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVA 208
Cdd:cd17325 81 ATS---YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 209 VIGLIAFVSLWFAVPHMNRMPKTRPMDELSA-------LVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHI 281
Cdd:cd17325 158 ALALLALVLALLLLPEPRPPPNKRAVSAARLrsglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 282 WIVLMAYGIGMVVGTYIGGWLSDRIGEWG-IMVALVLMVIMLSVFYFtSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDV 360
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPlILIGLLLSAVALLLLPL-ATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1093448552 361 AGR-AQTLAAALNQAALNMANAFGAALGGWVIASgYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17325 317 VPPeGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA-FGFATPFLAAAALLLLAAVLFL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
45-431 |
1.25e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.88 E-value: 1.25e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 45 VIVALSVGAFGIGVTEFVAMGLL-PYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGn 123
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLaPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 124 gaTVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSA 203
Cdd:COG2223 84 --LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 204 FAFVAVIGLIAFVSLWFAV----PHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSEN 279
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 280 HIWIVLMAYGIGMVVGTYIGGWLSDRIG-EWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLM 358
Cdd:COG2223 242 TAGLLAALFALLGALGRPLGGWLSDRIGgRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093448552 359 DVAGRAQTLAAA-LNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIALptiVLYRRSQAKKAE 431
Cdd:COG2223 322 DIFPTKNAGAVYgLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTL---LLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-424 |
4.46e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.94 E-value: 4.46e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 41 RRILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFT 120
Cdd:COG2271 7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 121 IGNGATVWAGTLGSFeavMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGW 200
Cdd:COG2271 87 LATLLFGFATSFWQL---LLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 201 RSAFAFVAVIGLIAFvslwfavphmnrmpktrpmdelsalvtpqVLLTVAIGTVGFGGMFAVYTYITWT---MTREAGMS 277
Cdd:COG2271 164 RAAFLILGLPGLLLA-----------------------------LLRFWLLALAYFLVYFALYGFLTWLptyLVEVRGLS 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 278 ENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQ--NAVLGTINFLLIGLLGSVLVPNLQT 355
Cdd:COG2271 215 LAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALlpSPALAIALLFLAGFGLGGAFGLLWA 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093448552 356 RLMDVAGRAQTlaaALNQAALNMANAFGAALGGWV---IASGYGYRAPALGGATLAMLAIFIALPTIVLYRR 424
Cdd:COG2271 295 LAAELFPKKAR---GTASGLVNTFGFLGGALGPLLvgyLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
49-416 |
1.34e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.79 E-value: 1.34e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGngaTVW 128
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG---ALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 129 AGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQI--YGWRSAFAF 206
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 207 VAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQ----------VLLTVAIGTVGFGGMFAVYTYITWTMTREAGM 276
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLlkrvlknpglWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 277 SENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGL-LGSVLVPNLQT 355
Cdd:cd06174 238 VAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFgLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1093448552 356 RLMDVAGRAQTLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-416 |
1.13e-18 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.88 E-value: 1.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 43 ILVIVALSVGAFGIGVTefvamgLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIG 122
Cdd:cd17489 1 ILLANFFFFLSFYLLLP------VLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 123 NGATVWAGTLGSFeavMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRS 202
Cdd:cd17489 75 TLLYLLATSVALL---LVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 203 AFAFVAVIGLIAFVSLWF--AVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITwTMTREAGMSenH 280
Cdd:cd17489 152 LFIVAAVLALLALLLVFLvkDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLP-LYAAERGIS--N 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 281 IWIVLMAYGIGMVVGTYIGGWLSDRIGE-WGIMVALVLMVIMLSVFYFTsQNAVLGTINFLLIGLLGSVLVPNLQTRLMD 359
Cdd:cd17489 229 AGLFFTVYAIALLLSRPFSGKLSDRKGPkTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVLYGLGFGLLFPALQALAVD 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1093448552 360 VAGRAQ-TLAAALNQAALNMANAFGAALGGWVIASgYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17489 308 LVPPHRrGAANGTFFIFFDLGIGLGGLLLGLVAEL-FGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
66-416 |
9.17e-18 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 84.54 E-value: 9.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGAtvwAGTLGSFEAVMVSRFIA 145
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL---CGLSDSFALLLAGRALQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIyGWRSAFAFVAVIGLIAFVSLWFAVPHM 225
Cdd:cd17474 98 GIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFLLPEP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 226 ---NRMPKTRPMDELSALVTPQVLLTVAIGT-VGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGW 301
Cdd:cd17474 177 kekAKSSSATKLRDLKKALRGRGLLTFLVSAfLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 302 LSDR--IGEWGIMVALVLMVIMLSVFYFTSQNAVLgTINFLLIGLLGSVLVPNLQTRLMDVAGRAQTlaaALNQAALNMA 379
Cdd:cd17474 257 LLKKrfGARRILVIGLLLYALSLLLLGFVPSLALL-LIAIVLFGLGLGLNLPLLTTLVTELAPEEER---GTASSLYNFV 332
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1093448552 380 NAFGAALGGWV---IASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17474 333 RFLGQAVGPLLfglLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
41-364 |
9.27e-18 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 84.72 E-value: 9.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 41 RRILVIVALSVGAFGIGVTEFVAMGL-LPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAF 119
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFaAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 120 TIGNGATVWAGTLGSFeavMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYG 199
Cdd:TIGR00895 93 SVFTLLCALATNVTQL---LILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 200 WRSAFAFVAVIGLIAFVSLWFAVPH----------------MNRMPKTRPMDELSALVTPQVLLTVAIGTVG-------- 255
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFLPEsidflvskrpetvrriVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKalfqgkta 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 256 ----------FGGMFAVYTYITWT--MTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLS 323
Cdd:TIGR00895 250 ritvllwllyFMLLVGVYFLTNWLpkLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAV 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1093448552 324 VFYFTSQNAVLgtinFLLIGLLGSVLVPNLQTRLMDVAGRA 364
Cdd:TIGR00895 330 LVGSTLFSPTL----LLLLGAIAGFFVNGGQSGLYALMALF 366
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
60-415 |
3.59e-17 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 82.66 E-value: 3.59e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 60 EFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIgngATVWAGTLGSFEAVM 139
Cdd:PRK10213 36 EFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTL---SCLLVSFANSFSLLL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 140 VSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLW 219
Cdd:PRK10213 113 IGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAAAVMGVLCIFWII 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 220 FAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIG 299
Cdd:PRK10213 193 KSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLVLLSFGIASFVGTSLS 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 300 GWLSDRIGEWGIMVA-LVLMVIMLSVFYFTSQNAVLGTInfLLIGLLGSVLVPN-----LQTRLMDVAGRAQTlaaaLNQ 373
Cdd:PRK10213 273 SFILKRSVKLALAGApLVLAVSALVLTLWGSDKIVATGV--AIIWGLTFALVPVgwstwITRSLADQAEKAGS----IQV 346
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1093448552 374 AALNMANAFGAALGGWVIaSGYGYRAP-ALGGATLAMLAIFIA 415
Cdd:PRK10213 347 AVIQLANTCGAAIGGYAL-DNIGLTSPlMLSGTLMLLTALLVT 388
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
67-416 |
1.28e-15 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 78.00 E-value: 1.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 67 LPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGtlgSFEAVMVSRFIAG 146
Cdd:cd17320 22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALAS---SIEQLLIARFLQG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 147 LPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVP--- 223
Cdd:cd17320 99 LGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetl 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 224 -HMNRMPKTRPM--DELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGG 300
Cdd:cd17320 179 pEEKRKPLLSSLlrAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 301 WLSDRIGE----WGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLG-SVLVPNLQTRLMD----VAGRAqtlaaal 371
Cdd:cd17320 259 RLVRRFGPrrllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGfGLIFPNATSLALEpfphVAGTA------- 331
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1093448552 372 nQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17320 332 -SALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLL 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
67-408 |
2.77e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 76.83 E-value: 2.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 67 LPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIgngATVWAGTLGSFEAVMVSRFIAG 146
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGL---ASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 147 LPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVslwfavphmn 226
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL---------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 227 rmpktrpmdelsalVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRI 306
Cdd:cd17321 166 --------------LARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 307 GEWGIMVA-LVLMVIMLSVFYFTSQNAVLGT--INFLLIGL-LGSVLVPNLQTRLMDVAGRAQTLAAALNQAALNMANAF 382
Cdd:cd17321 232 GPRLVLVAgLLLTAVGLLLLALLGADSSVWLllPGLVLLGLgLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGAL 311
|
330 340
....*....|....*....|....*.
gi 1093448552 383 GAALGGWVIASGYGYRAPALGGATLA 408
Cdd:cd17321 312 GVALLGALLTAGLSANLGDSGVAALL 337
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
62-425 |
5.75e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 75.70 E-value: 5.75e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 62 VAMG-LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFeavMV 140
Cdd:cd17365 16 AVMGfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL---AL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 141 SRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIafvslwf 220
Cdd:cd17365 93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLI------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 221 avphmnrmpktrpmdelsalVTPQVLLTVAIGTVGFGGMFAVYTYITWTMT--REAGMSENHIWIVLMAYGIGMVVGTYI 298
Cdd:cd17365 166 --------------------LLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKlmVEAGYSLSQALTITLLLNIGGVIGSLL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 299 GGWLSDRIG-EWGIMVALVLMVIMLSVF-YFTSQNAVLGTINFLL-IGLLGS-VLVPNLQTRLMDVAGRAqtLAAALNQA 374
Cdd:cd17365 226 LGWLADRFGpKRVLALFFALGAVSLALLgVSPASLVLLYVLVFLAgACVNGAqVGLYALAARFYPTEVRA--TGVGWALG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1093448552 375 ALNMANAFGAALGGWVIASGYGyraPALGGATLAMLAIFIALPTIVLYRRS 425
Cdd:cd17365 304 VGRLGAILGPLLGGLLLAAGLG---PESVFLALAIPAALGALAVLLLRLRR 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
49-342 |
7.79e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 75.69 E-value: 7.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGngaTVW 128
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLG---SLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 129 AGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVA 208
Cdd:cd17503 78 CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 209 VIGLIAFVSLwfavphmnrmpktrPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAY 288
Cdd:cd17503 158 PIGILALLLA--------------PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPG 223
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 289 GIGMVVGTYIGGWLSDRIGE-WGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLI 342
Cdd:cd17503 224 GLASAILSPLVGRLLDKFGPrLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLF 278
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-361 |
1.77e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 74.53 E-value: 1.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 46 IVALSVGAFGIGVTeFVAMGLLPYIAGAF-GRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNG 124
Cdd:cd17473 2 ITLLLASTLTVMAG-AAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 125 ATVWagtLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIyGWRSAF 204
Cdd:cd17473 81 AGLF---LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 205 AfVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVY---TYITWTMTREAGMSENHI 281
Cdd:cd17473 157 L-VYLLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYvipIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 282 WIVLMAYGIGMVVGTYIGGWLSDRIGE-WGIMVALVLMVIMLSVFYFTSQNAVLGtINFLLIGLLGSVLVPNLQTRLMDV 360
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKrRLLAIGFALMALGFLLLALASGLWVVL-LGAILAGLGFGLLLPTLNSWAMSL 314
|
.
gi 1093448552 361 A 361
Cdd:cd17473 315 V 315
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
40-428 |
2.85e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 74.12 E-value: 2.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 40 LRRILVIVALSVGAFGIGVTefVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAF 119
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATA--LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 120 TIGNGATVWAGTLGSFeavMVSRFIAGLPHGAYFSVAALVAASLAkPGQRGKMVALSGVGLSVATVIG---VPAAQVLGQ 196
Cdd:COG0738 84 ALGLLLFALAPSYPLL---LLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGpllGGLLILLGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 197 IYGWRSAFAFVAVIGLIAFVSLWF----AVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTR 272
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRsklpEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 273 EAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPN 352
Cdd:COG0738 240 VLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1093448552 353 LQTRLMDVAGRAQTLAAALNQAALNMANAFGAALGGWvIASGYGYRApalGGATLAMLAIFIALPTIVLYRRSQAK 428
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF-LADAFGLRA---AFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
66-416 |
4.48e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.99 E-value: 4.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFeavMVSRFIA 145
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL---YVLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVPHM 225
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 226 nrmpktrpmdelsalvtpqvlltVAIGTVGFGGMFAVYTYITWT---MTREAGMSENHIWIVLMAYGIGMVVGTYIGGWL 302
Cdd:cd17319 182 -----------------------WGLALGYFGINYALYGLLTWLptyLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 303 SDRIGE----WGIMVALVLMVIMLSVFYFTSQNAVlgTINFLLIGLLGSVLV-PNLQTRLMDVAGRAQTLAAALNQ-AAL 376
Cdd:cd17319 239 SDRLLRgarrLVIIIGLLLAAVGLLLAYLTTSPVV--AVILLSLAGFGIGAAsPVFWSLPADLLPGEAAATAGGLInSGG 316
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1093448552 377 NMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17319 317 NLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
166-421 |
9.76e-14 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 9.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 166 PGQRGKMVA----LSGVGLSVATVIGVPAAQVLG--QIYGWRSAFAFVAVIGLIAFVSLWFAVP--HMNRMPKTRPMDEL 237
Cdd:COG2211 142 YEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFGgdAALGYRLTALIFAVLGLLAFLLTFFGTKerPVPEEEKVSLKESL 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 238 SALVTPQVLLTVAIGTV-GFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIG-EWGIMVAL 315
Cdd:COG2211 222 KALLKNRPFLLLLLAYLlFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGkKKAFIIGL 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 316 VLMVIMLSVFYFTS-QNAVLGTINFLLIGLLGSVLVPNLQTRLMDVA--GRAQTLAAA------LNQAALNMANAFGAAL 386
Cdd:COG2211 302 LLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdyDEWKTGRRReglyfgIFTFAIKLGQALAGAL 381
|
250 260 270
....*....|....*....|....*....|....*.
gi 1093448552 387 GGWVIA-SGYGYRAPALGGATLAMLAIFIALPTIVL 421
Cdd:COG2211 382 AGLLLAlFGYVAGAAQSPSALTGIRLLFFLLPAVLL 417
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-348 |
1.68e-13 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 71.44 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 45 VIVALSVGAFGIGVTefvaMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIgng 124
Cdd:cd17477 1 LLLSVALLGLGSGLL----LPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAV--- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 125 ATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGvpaaQVLGQIYGWRSAF 204
Cdd:cd17477 74 SVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG----PLLLALVGTAGAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 205 AFVAVIGLIAFVSLWFAVPHMNRMPKTRPMD-ELSALVTPQVLLTVAIGTVGFG-----GMFAVYTYitwtmtrEAGMSE 278
Cdd:cd17477 150 PFLIAAVLLLLALVPLLLTRRAAPEIEEAESiSLRRLLRIAPLALLGAFVAGFLegafySLLPLYGL-------RLGLSV 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093448552 279 NHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVF--YFTSQNAVLGTINFLLIGLLGSV 348
Cdd:cd17477 223 AQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLlpLVPGLPLALLVLLFLWGGAAGPL 294
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
66-341 |
2.02e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 71.56 E-value: 2.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGngaTVWAGTLGSFEAVMVSRFIA 145
Cdd:cd17371 21 VLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVF---TLLCGFAQNYWQLLILRALA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAKPGQRGKMVAL----SGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFV----- 216
Cdd:cd17371 98 GLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFirrfv 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 217 ---SLWFAVPHMNRMPKTRPMdeLSALVTPQVLLTVAIGTVGFGG-MFAVYTYITWT---MTREAGMSENHIWIVLMAYG 289
Cdd:cd17371 178 kepPQWQAARAARRHFADRPS--LRELFSPPLLRTTLLASLLATGaLGGYYGITTWLpsyLTGERGLSFEGSAGYLVVTI 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1093448552 290 IGMVVGTYIGGWLSDRIGEWGIMV--ALVLMVIMLSVFYFTSQNAVLGTINFLL 341
Cdd:cd17371 256 LGGFLGYLAGGFLADRIGRRNNFAlfALGSAISILLYFFLPLSPTLILILGFPL 309
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
41-416 |
3.49e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.67 E-value: 3.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 41 RRILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFT 120
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 121 IGngaTVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAkPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGW 200
Cdd:COG2807 95 AG---LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 201 RSAFAFVAVIGLIAFVsLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITW--TMTREAGMSE 278
Cdd:COG2807 171 RGALAVWALLALLALL-LWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWlpPILRDAGLSA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 279 NHIWIVLMAYGIGMVVGTYIGGWLSDRIG--EWGIMVALVLMVIMLSVFYFTSQNAVLGTInfLLIGLLGSVLVPNLQTR 356
Cdd:COG2807 250 ATAGLLLSLFQLAGIPGSLLVPLLADRLGdrRPLLLLLGLLGLAGLLGLLLAPGSLPWLWA--VLLGLGQGGLFPLALTL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093448552 357 LMDVAGRAQTLAAA--LNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:COG2807 328 IGLRARTPAEAAALsgMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
46-416 |
6.61e-13 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 69.55 E-value: 6.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 46 IVALSVGAFGIGVTEFVAMGLLPYIAGAF--GRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGN 123
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 124 GATVWAGTLGSFeavMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVAL----SGVGLSVATVIGVPAAQVLGQIYG 199
Cdd:cd17316 81 LLIGLLPTPILL---LVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLlqsgWALGALLAALVASLLIPLLSGDWG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 200 WRSAFAFVAVIGLIAFvslwfavphmnrmpktrpmdelsaLVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSEN 279
Cdd:cd17316 158 WRILFLIGALPALLAL------------------------LLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 280 HIWIVLMAYGIGMVVGTYIGGWLSDRIG-EWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLI----GLLGSVLVPNLQ 354
Cdd:cd17316 214 TSSLYLLLISLGALVGALIAGLLSDRIGrKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFIlsffVGGVWGALYAYL 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093448552 355 TRLMDVAGRAqtLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17316 294 AELFPTEVRA--TGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
34-328 |
6.60e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 65.99 E-value: 6.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 34 QDDISDLRRILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLL 113
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 114 LLMAAFTIgngATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQV 193
Cdd:COG0477 84 IGLLLFGL---ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 194 LGQIYGWRSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTRE 273
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 274 AGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFT 328
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
49-415 |
1.69e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.29 E-value: 1.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVW 128
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 129 AGtlgSFEAVMVSRFIAGLPhGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVA 208
Cdd:cd17504 81 AP---NLPVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 209 VIGLIAFVSLwfavphmnrmpktrPMDELSALVTPQVLLTVAIG-TVGFGGMFAVYTYITWTMTREA---GMSENHIWIV 284
Cdd:cd17504 157 PVAVLLAALV--------------PLIDLRLLRRRNVLLANITAlLAGFGMFMVFQLLPQLLQLPTPtgfGLGITEAGLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 285 LMAYGIGMVVGTYIGGWLSDRIGEWGIMVA-LVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAGR 363
Cdd:cd17504 223 LLPGALVMLIAGPLAGRLIARVGPRRVLLIgLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPP 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1093448552 364 AQTLAAALNQAAL-NMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIA 415
Cdd:cd17504 303 DRTGIATGMNTVLrTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLI 355
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
43-257 |
4.10e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 64.71 E-value: 4.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 43 ILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIG 122
Cdd:TIGR00711 1 LLLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 123 ngaTVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRS 202
Cdd:TIGR00711 81 ---SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRW 157
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 203 AFAFVAVIGLIAFVSLWFAVPHMNRmPKTRPMDELSALvtpqvLLTVAIGTVGFG 257
Cdd:TIGR00711 158 IFLINVPIGIIVVVVAFFILPRDKP-AASENFDFLGLL-----LLSVGLGSLLYG 206
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
58-416 |
1.70e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 62.21 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 58 VTEFVAMGLLPYIAGAfgrdedaagrMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNgatVWAGTLGSFEA 137
Cdd:cd17330 23 VREFNKLGASGYYVGL----------LQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSY---VLLGLSRNLWL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 138 VMVSRFIAGLpHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVS 217
Cdd:cd17330 90 LFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 218 LWFAVPHMNRMpktrpmdelsalvtpqvLLTVAIGTVGFGGMFAVYTYItwtMTREAGMSENHIWIVLMAYGI-GMVVGT 296
Cdd:cd17330 169 VLFFLPPLRRL-----------------LLVYFLIALAFAGLESVFSLF---LKDRFGFSPSQIGLLLALVGIaGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 297 YIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAG-RAQTLAAALNQAA 375
Cdd:cd17330 229 LLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPsKEQGKAQGIIQSL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1093448552 376 LNMANAFGAALGGWVIASgYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17330 309 QSLARIIGPLLAGPLYSF-LGPGVPFLLAAGLLLIALFLLS 348
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
43-418 |
3.51e-10 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 61.52 E-value: 3.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 43 ILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIG 122
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 123 NGATVWAGTLGSFEAVMVsrFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRS 202
Cdd:cd17355 82 LVLLALATSLWQLYLLWG--LLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 203 AF-AFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQV----------LLTVAIGTVGFGGMFAVYTYItwTMT 271
Cdd:cd17355 160 ALlVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLkealrsasfwLLALAFFLCGFAVVGLIVHLV--PYL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 272 REAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINF-LLIGLLGSVLV 350
Cdd:cd17355 238 ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFaALFGLGWGATV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1093448552 351 PNLQTRLMDVAG-RAQTLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIALPT 418
Cdd:cd17355 318 PLTAALAARYFGaRSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
44-416 |
3.54e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.48 E-value: 3.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 44 LVIVALSVGAFGIGVTEFVamglLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLL---LLMAAFT 120
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVA----LPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIladLLRALLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 121 IGNGATVWAGTLgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGW 200
Cdd:cd06173 79 AVLALLALLGSL-SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 201 RSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALV--------TPQVLLTVAIGTVGFGGMFAVYTYITWTMTR 272
Cdd:cd06173 158 GGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLReglrylrrSPLLRLLLLALALFALLGGALTVLLPLLAKE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 273 EAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPN 352
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 353 LQT-RLMDVAGRAQTLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd06173 318 LNTlLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
65-350 |
3.95e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.02 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 65 GLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTignGATVWAGTLGSFEAVMVSRFI 144
Cdd:cd17328 20 GVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWS---AATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 145 AGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQ-IYGWRSAFAFVAVIGLIAFVSLWFAVP 223
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 224 ----------HMNRMPKTRPMDELSALVTPQVLLTVAIGtvGFGGMFAVYTYITWTMT------REAGMSENHI-WIVLM 286
Cdd:cd17328 177 epprgaaeggVMAKSTATSFLADLKALAKNPSFILSTLG--FTAVSFVTGALAFWAPTfflrafGVGDLSSADVgLIFGA 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1093448552 287 AYGIGMVVGTYIGGWLSDRIGEWGIMV-ALVLMVIMLSVFYFTSQNAVLGTINFL---LIGLLGSVLV 350
Cdd:cd17328 255 ITCIAGVLGVLLGGILADRLRRKTPRAdPLVCAVGLLAAAPFLFLALVLALSNLLlawVLLFLGEFLL 322
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
43-357 |
1.46e-08 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 56.49 E-value: 1.46e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 43 ILVIVALSvgAFGIGVTefvaMGLLPYIAGAFGRDEDAA----GRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAA 118
Cdd:cd17388 4 ILVTVLLD--AMGIGLI----MPVLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 119 FTIGNGATVWAGTLGSFeavMVSRFIAGLPhGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQiY 198
Cdd:cd17388 78 AALDYLLMAFAPTLWWL---YLGRIIAGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-I 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 199 GWRSAFAFVAVIGLIAFVSLWFAVPHmnRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYI---------TWT 269
Cdd:cd17388 153 SPRAPFLVAAGLNGLNFLLGLFVLPE--SLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIqligqvpatTWV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 270 MTREA--GMSENHIWIVLMAYGI-GMVVGTYIGGWLSDRIGEWG-IMVALVLMVIMLSVFYFTSQNAVLgtINFLLIGLL 345
Cdd:cd17388 231 LFTEDrfDWSPTMVGLSLAVFGLlHALFQAFVTGPIAKRLGEKRaILLGLAADALGFLLLAFATQGWMV--FPILILLAL 308
|
330
....*....|..
gi 1093448552 346 GSVLVPNLQTRL 357
Cdd:cd17388 309 GGIAGPALQGLL 320
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
62-344 |
4.63e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 54.88 E-value: 4.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 62 VAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFeavMVS 141
Cdd:cd17359 19 VINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIF---IIA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 142 RFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSG----VGLSVATV----IGVPAAQVLGQIYGWRSAFAFVAVIGLI 213
Cdd:cd17359 96 RIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQlmivFGQLLAYIvnylIANAGGADWLGAEGWRWMLGLEAIPAIL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 214 AFVSLWFaVPHMNR--MPKTRPMdelsalvtpqVLLTVAIGTVG-FGGMFAVYTYITwTMTREAGMSENHIWIVLMAYGI 290
Cdd:cd17359 176 FLLGMLF-IPESPRwlVSKGKPI----------LIIGIGLAIFQqFVGINVIFYYGP-EIFQNAGFSENAALLQTIGIGV 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1093448552 291 GMVVGTYIGGWLSDRIG-----EWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGL 344
Cdd:cd17359 244 VNVIFTIIAILLVDKVGrkpllLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILL 302
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
67-421 |
6.62e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.20 E-value: 6.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 67 LPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRML---LLLMAAFTIGNGATVWagtLGSFEAVMVsrf 143
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMsagLLLSALANIFMGFSTS---LWFFAVLWG--- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 144 IAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVp 223
Cdd:cd17312 100 LNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 224 hmnrmpktrpmdelsaLVTPQVLLTVAIGTVGFGGM-FAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWL 302
Cdd:cd17312 179 ----------------RDSPPYVWVLSLAYAFVYIVrYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 303 SDRIGEWGIMVALVLMVIMLSV----FYFTSQNAVLGTINFLLIGLLGSVLVpNLQTRLMDVAGRAQTLAAALNQAALNM 378
Cdd:cd17312 243 SDKLFGGRRAPIAVIYMLLMTLslalFWFFPHNKLLSIVLLFLIGFFVGGPI-NLIGGAAAQDIGRKEAAGTATGFVGLF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1093448552 379 ANAfGAALGGWVIasgyGYRAPALGGATLAMLAIFIALPTIVL 421
Cdd:cd17312 322 GYL-GASLAGLPL----GYIIDHYGWSTVFYFLISAALLSVLL 359
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
62-306 |
1.20e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 53.35 E-value: 1.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 62 VAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFeavMVS 141
Cdd:cd17323 17 IYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML---IIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 142 RFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVslwfa 221
Cdd:cd17323 94 RFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLI----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 222 vphmnrmpktrpmdeLSALVTPQVLLTvaigtvgfgGMFAVYTYITWTMTREA---------GMSENHIWIVLMAYGIGM 292
Cdd:cd17323 169 ---------------LIFLFLPIVLLL---------GLYVGLVYAILYLFLTAfpyvfgevyGFSPGEVGLMYLPIGIGA 224
|
250
....*....|....
gi 1093448552 293 VVGTYIGGWLSDRI 306
Cdd:cd17323 225 LIGSIIGGRLSDYY 238
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
84-220 |
1.28e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 53.42 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 84 MISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASL 163
Cdd:cd17357 54 IVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEI 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1093448552 164 AKPGQRGKMVALSGVGLSVATVIGVPAAQ--VLGQIYGWRSAFAFVAVIGLIAFVSLWF 220
Cdd:cd17357 134 SPSELRGALGSLTQIGVTLGILLGQVFGLpsVLGTETLWPYLLFFPGIPALLQLAALPF 192
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
66-342 |
1.73e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 52.95 E-value: 1.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGrDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGngaTVWAGTLGSFEAVMVSRFIA 145
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELG---SLLCGLAPNMTMLIVGRAIQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLwfavphm 225
Cdd:cd17502 94 GIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGLALALL------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 226 nrmpktrpmdelsalvtPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDR 305
Cdd:cd17502 167 -----------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISK 229
|
250 260 270
....*....|....*....|....*....|....*....
gi 1093448552 306 IG--EWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLI 342
Cdd:cd17502 230 TGryKPLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLI 268
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
106-416 |
2.97e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.22 E-value: 2.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 106 IPRRRMLLLLMAAFTIGNgatVWAGTLGSFEAVMVSRFIAGLphGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATV 185
Cdd:cd17472 59 IGRKPVILFGLLLFIAGS---LLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGIAFA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 186 IGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDE---LSALVTPQVLLTVAIGTVGFGGMFAV 262
Cdd:cd17472 134 ISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKkklKKLLKNKRLLRLDFSIFILHFVLMAF 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 263 YTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTyiggwLSDRIGE-----WGIMVALVLMVIM-LSVFYFTSQNAVL-- 334
Cdd:cd17472 214 FYILPLLLTQLGGGKGQLWKVYLPAILIGFILMV-----PFVIYAEkkgkmKQVFVSSILLIAVgFLLLLFAATSLWLli 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 335 -GTINFLLIGLLGSVLVPNLQTRLMDVAGRAQTlaAALNQAALNMANAFGAALGGWVIASgYGYRAPALGGATLAMLAIF 413
Cdd:cd17472 289 iGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTA--MGIYNTSQFLGSFLGGALGGLLWGL-LGYSSVFLTILILALLWLL 365
|
...
gi 1093448552 414 IAL 416
Cdd:cd17472 366 VSF 368
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
46-416 |
6.41e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 6.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 46 IVALSVGAFGIGVTEFVAMGLLP-YIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGng 124
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAiYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALG-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 125 aTVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQiYGWRSAF 204
Cdd:cd17329 79 -FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 205 AFVAVIGLIAFVSLWFAVPHmnRMPKTRPMDELSALVTPQVLLT-------VAIGTVGFGGMFAVYTYITWTMTREAGMS 277
Cdd:cd17329 157 LAAAVLFLLAALVLLFLLPE--TRPKRRAAEKTEILRGYKIVLRdrafllfLLASFLISLIYFQLESTLPVYVVEILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 278 ENHIWIVLMAYGIGMVVGTY-IGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLL-IG-LLGSVLVPNLQ 354
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFpVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtLGeMLVFPAVQTLV 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093448552 355 TRLMDVAGRAQTLAAALNQAALnmANAFGAALGGWVIaSGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17329 315 AALAPPDKRGSYMGFYALAWGL--GRAIGPLVGGLLL-DLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
53-307 |
1.01e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 50.38 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 53 AFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGtl 132
Cdd:cd06180 8 AVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTS-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 133 gSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVAL--SGVGLSVAtVIGVPAAQVLGQIYGWRSAFAFVAVI 210
Cdd:cd06180 86 -GFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLlfAGVGLGIA-LSGLLVPAGLGGGLSWRAGWLALALL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 211 GLIAFVSLWFAVPHMNRMPKTRPMDE-LSALVTPQVLLTVAIGTVGFGGMfAVYTYITWTMTREAG--MSENHIWIVLma 287
Cdd:cd06180 164 SAVLLLLSFLLLRRGPSAPTEASAAEsAPGLNRPLWRLALAYGLFGFGYI-ITATFLPLIARETGAgsLLAGLLWSLF-- 240
|
250 260
....*....|....*....|
gi 1093448552 288 yGIGMVVGTYIGGWLSDRIG 307
Cdd:cd06180 241 -GLAAVPSCFLWGALSDRWG 259
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-221 |
1.26e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.31 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 19 RRAGAFSSHRRPVPVQDDISDLRRILVIVALSVGAFGIGVTEFVAMG---LLPYIA-GAFGRDEDAAGRMISMYALGVVV 94
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGAltvLLPLLAkEVLGGGAAGYGLLLAAFGVGALL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 95 GAPLITVLTGSIPRRRMLLLLMAAFTIgngATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVA 174
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGL---ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFS 336
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1093448552 175 LSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFA 221
Cdd:cd06173 337 VYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
66-413 |
1.45e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGnGATVWAGTlgSFEAVMVSRFIA 145
Cdd:cd17333 18 LGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLA-LALIFATP--SIYLFVVLMFLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAKPGQRGKMVALSGVgLSVATVIGVPAAQVLGQIYGWRS-----AFAFVAVIGLIAFVSLWF 220
Cdd:cd17333 95 GLGAGILDTGANTFVGALFEESSATRLNVLHGF-FGLGALIGPLIATSLLTSELSWSwayliIGLIYLLLAILILLTLFP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 221 AVPHMN---RMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTY 297
Cdd:cd17333 174 ELPSARnpqQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 298 IGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAGRAQTLAAALNQAALN 377
Cdd:cd17333 254 LGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGS 333
|
330 340 350
....*....|....*....|....*....|....*.
gi 1093448552 378 MANAFGAALGGWVIASGYGYRAPALGGATLAMLAIF 413
Cdd:cd17333 334 IGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
245-419 |
1.48e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.97 E-value: 1.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 245 VLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSV 324
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 325 FYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAGRAQ-TLAAALNQAALNMANAFGAALGGWvIASGYGYRAPALG 403
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGL-LADLFGWRWVFLV 169
|
170
....*....|....*.
gi 1093448552 404 GATLAMLAIFIALPTI 419
Cdd:COG2814 170 NAVLALLALLLLLRLL 185
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
66-346 |
1.50e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.86 E-value: 1.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGtlgSFEAVMVSRFIA 145
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP---NYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAkPGQRGKMVALSGV----GLSVATVIGVPAAQVLGQI-YGWRSAFAFVAVIGLIAFVSLWF 220
Cdd:cd17478 95 GIGSAAFHPEGARLASQAA-GGRRGLAMSIFSVggnlGFALGPLIAAALVALFGGLgLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 221 AVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGgMFAVYTYITwTMTREAGMSENHIWIVLMAYGIGMVVGTYIGG 300
Cdd:cd17478 174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWV-LSSLTTFLP-FYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGG 251
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1093448552 301 WLSDRIGE-WGIMVALVLMVIMLSVFYFTSqnavlGTINFLLIGLLG 346
Cdd:cd17478 252 PLSDRFGRrRVIIASLLLAAPFLLLFLLTP-----GIWSYILLVLAG 293
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
66-350 |
1.51e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 49.99 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMIS---MYALGVV---VGAPLITVLTGSIPRRRMLLL---LMAA--FTIGNGAT-----VWA 129
Cdd:cd17367 21 FALYFAPQFFPSGDPTVALLStaaVFAVGFLmrpIGGWLFGRLADRIGRRAALTLsvsLMAAgsLVIAVTPTyatigIWA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 130 GTLgsfeaVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGV----GLSVATVIGVPAAQVLGQ----IYGWR 201
Cdd:cd17367 101 PII-----LLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVtligGQLLALGVLLVLQHTLGEdqmaAWGWR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 202 SAFAFVAVIGLIAFV-------SLWFAVPHMNRMPKTRPMDELsaLVTPQVLLTVaIGTVGfGGMFAVYTYITWT---MT 271
Cdd:cd17367 176 IPFLLGGVLAVVVLWlrrgleeTESFEAIAESNEASAGTLREL--RRHPRELLLV-VGLTA-GGTLAFYTWTTYLqkfLV 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1093448552 272 REAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLV 350
Cdd:cd17367 252 NTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLVFL 330
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
68-324 |
2.49e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.58 E-value: 2.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 68 PYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGtlgSFEAVMVSRFIAGL 147
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAW---DFPSLLVARLLTGV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 148 PHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFaFVAVIGLIAFVSLWFAVPHMNR 227
Cdd:PRK11551 116 GLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF-YVGGVGPLLLVPLLMRWLPESR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 228 MPKTRPMDELSALVTPQVLL-------TVAIGTVGFGGMFAVYTYITW--TMTREAGMSENHIWIVLMAYGIGMVVGTYI 298
Cdd:PRK11551 195 AFAQAAGAGKQRAPVLRALFgegrataTLLLWISYFFTLIVLYFLLNWlpSLLVGQGLSRSQAGLVQIAFNIGGALGSLL 274
|
250 260
....*....|....*....|....*.
gi 1093448552 299 GGWLSDRIGeWGIMVALVLMVIMLSV 324
Cdd:PRK11551 275 IGALMDRLR-PRRVVLLIYAGILASL 299
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
258-436 |
3.90e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 258 GMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMV-ALVLMVIMLSVFYFtSQNAVLGT 336
Cdd:cd17329 14 GFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLaGLLLRALGFALLGF-AHSPWLFA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 337 INFLLIGLLGSVLVPNLQTRLMDVA-GRAQTLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGAT-LAMLAIFI 414
Cdd:cd17329 93 IALVLTGFGGGLFEPASEAMIADVTtPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFlLAALVLLF 172
|
170 180
....*....|....*....|..
gi 1093448552 415 ALPTIVLYRRSQAKKAERIELR 436
Cdd:cd17329 173 LLPETRPKRRAAEKTEILRGYK 194
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
133-223 |
6.44e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.00 E-value: 6.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 133 GSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGL 212
Cdd:cd17318 109 GGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGL 188
|
90
....*....|.
gi 1093448552 213 IAFVSLWFAVP 223
Cdd:cd17318 189 LWCLLWFFLVL 199
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
82-331 |
8.11e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 48.04 E-value: 8.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 82 GRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAA 161
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 162 SLAKPGQRGKMVALSGVGLsvatVIGVPAAQVLGQIY-------GWRSAFAFVAVIGLIAFVSLWFaVP----------- 223
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAI----TFGILLAYIFGLGLnktsnsdGWRIPLGLQLVPALLLIIGLLF-LPesprwlvekgr 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 224 ----------------------------HMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFG---GMFAVYTYITwTMTR 272
Cdd:pfam00083 204 leearevlaklrgvpdvdreldeikdslEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQqltGINAIFYYST-TIFE 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093448552 273 EAGMSENHIWIVLMayGIGMVVGTYIGGWLSDRIGE-----WGIMVALVLMVIMLSVFYFTSQN 331
Cdd:pfam00083 283 NLGLSDSFLVTIIV--GVVNFVFTFIAIFLVDRFGRrplllLGAAGMAICFVILGIVALLGVSK 344
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
67-364 |
1.17e-05 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 47.38 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 67 LPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGTLGSFeavMVSRFIAG 146
Cdd:TIGR00710 28 FPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL---LVLRFVQA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 147 LPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFavphmn 226
Cdd:TIGR00710 105 FGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFF------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 227 RMPKTRPMDELSALVT-----------PQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVG 295
Cdd:TIGR00710 179 ILPETLPYEARIQISTyfetfllllksKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1093448552 296 TYIGGWLSDRIGEWGI----MVALVLMVIMLSVFYFTSQNAVLGTIN-FLLIGLLGSVLVPNLQTRLMD----VAGRA 364
Cdd:TIGR00710 259 GFLNGRFIKKWGAKSLlrmgLILFAVSAVLLEITAILGLGSWAMIIGpMMFVGIGNSMISSIAMAYALEdfphVAGTA 336
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
25-222 |
2.33e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 25 SSHRRPVPVQDDISDLRRILVIVALSVGAFGIGVTEFVAMGLLP----YIAGAFGRDEDAAGRMISMYALGVVVGAPLIT 100
Cdd:cd17325 177 PPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPflplYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 101 VLTGSIPRRRMLLLLMAAFTIgngATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGL 180
Cdd:cd17325 257 KLSDRIGRKPLILIGLLLSAV---ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1093448552 181 SVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAV 222
Cdd:cd17325 334 SLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
30-218 |
2.58e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.01 E-value: 2.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 30 PVPVQDDISDLRRILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRR 109
Cdd:cd17477 174 EIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRR 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 110 RMLLLLMAAFTIGNGATVWAGTLGSfeAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVP 189
Cdd:cd17477 254 RVLLGCALLGALAALLLPLVPGLPL--ALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPL 331
|
170 180
....*....|....*....|....*....
gi 1093448552 190 AAQVLGQIYGWRSAFAFVAVIGLIAFVSL 218
Cdd:cd17477 332 LAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
82-331 |
2.70e-05 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 46.09 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 82 GRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGngATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAA 161
Cdd:cd17356 48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIG--AIIQVAAIGKWYQLIVGRIIAGLGVGFASVLVPVYQS 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 162 SLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYG---WRSAFAFVAVIGLIAFVSLWFavphmnrMPKtrpmdels 238
Cdd:cd17356 126 EVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGsaqWRIPLGLQIVWGLLLLIGMFF-------LPE-------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 239 alvTPQVLLTVAIGT-----VGFGGMFAVYTYITwTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGE----- 308
Cdd:cd17356 191 ---SPRWLYRTILGImlqlfQQLTGINYFFYYGT-TIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRrtcll 266
|
250 260
....*....|....*....|...
gi 1093448552 309 WGIMVALVLMVIMLSVFYFTSQN 331
Cdd:cd17356 267 IGAAGMSICLFIYAAVGVRYLIP 289
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
179-414 |
4.74e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 45.23 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 179 GLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVP--HMNRMPKTRPMDELSALVTPQVLLTVAIGTVGF 256
Cdd:cd17471 133 AFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPsvKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLF 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 257 GGMFAVYTYITWTMTREAGMSENHI-WIVLMAYGIGMVVgTYIGGWLSDRIG-EWGIMVALVLMVIMLSVFYFTSQNAVL 334
Cdd:cd17471 213 AANSMYIIAMPLYVTNELGGSESWVgLLFGLAAALEIPI-MLLAGLLAKRFGkRRLLLAGFLAGVLFYLGLALATSLWQL 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 335 GTI---NFLLIGLLGSVLVPNLQTRLMDVAGRAQTLAAALNQAalnmANAFGAALGGwVIASGYGYRAPALGGATLAMLA 411
Cdd:cd17471 292 IALqllNAIFIGITAGLGISYFQDLMPGQPGLATTLYSNASRI----GSLLGGLLAG-VIAQYFGYRAVFLVCAVLALLA 366
|
...
gi 1093448552 412 IFI 414
Cdd:cd17471 367 LVL 369
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
85-349 |
5.24e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 45.29 E-value: 5.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 85 ISMYALGVVVGAPLIT---------VLTGSIPRRRMLLLLMAAFTIGngATVWAGTLGSFEAVMVSRFIAGLPhGAYFSV 155
Cdd:cd17490 28 ASLSMIGIILGAYGISqmllriplgILSDRIGKRKLFIIIGLLFTVL--ASLIMILFPSPWGLLIARFLSGIA-AATWVS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 156 AALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFAVPH-MNRMPKTRPM 234
Cdd:cd17490 105 FTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEErREKKPVLTEL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 235 DELSALVTPQVLLTVAI-GTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWL-SDRIGE--WG 310
Cdd:cd17490 185 KELLSVLKDKKLLFFSLlAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGErnTI 264
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1093448552 311 IMVALVLMVIMLSVFYFTSQNAVLGT--INFLLIGLLGSVL 349
Cdd:cd17490 265 IIGFLLLGAYCFLIPFAPNLTLLYLLqaLNGFGTGILFPLL 305
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
177-351 |
5.77e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 177 GVGLSVATVIGVPAAQVLGqiYGWRSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIgtvgF 256
Cdd:cd17339 131 NLGAALASGLSVPLAQALG--GGWRGALAIWALPALLALLIWLPQLRRRKRAAAAAAPLTKISVWRSPLAWQVTL----F 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 257 GGM--FAVYTYITW--TMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRI-GEWGIMVALVLMVI--MLSVFYFTS 329
Cdd:cd17339 205 MGLqsLLFYTLMAWlpTILIDAGLSAATAGWLLSLFQLVGIPASLLVPILATRLkNQRPIVVLLAVLFIigVLGLLFAPT 284
|
170 180
....*....|....*....|..
gi 1093448552 330 QNAVLGTInflLIGLLGSVLVP 351
Cdd:cd17339 285 ALALLWAV---LLGLGGGAAFS 303
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
256-416 |
6.73e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 256 FGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGE-WGIMVALVLMVIMLSVFYFTSQNAVL 334
Cdd:pfam07690 9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRrRVLLIGLLLFALGLLLLLFASSLWLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 335 gTINFLLIGLLGSVLVPNLQTRLMDVAGRAQ-TLAAALNQAALNMANAFGAALGGWvIASGYGYRAPALGGATLAMLAIF 413
Cdd:pfam07690 89 -LVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAILSLLAAV 166
|
...
gi 1093448552 414 IAL 416
Cdd:pfam07690 167 LLL 169
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
174-422 |
7.11e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.90 E-value: 7.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 174 ALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWFA--------VPHMNRMPKTRPMDELSALVTPQV 245
Cdd:cd17332 143 FFATIGGLLVTVLPPPLVAYFGGGNASRGYFLTALIIGIIGIILLLICffgtrervVPPEEEKSKLPLLKSLKALLKNRP 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 246 LLTVAIGT----VGFGGMFAVYTYIT--WTMTREAGMsenhiwIVLMAYGIGMVVGTYIGGWLSDRIG-EWGIMVALVLM 318
Cdd:cd17332 223 FLILLLAYllyfLAFNIVNTVLVYYFkyVLGGRAELV------LLLLLILSGALLALLPWPPLKKRFGkKKAFFIGLLLA 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 319 VIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLM-DVAG--------RAQTLAAALNQAALNMANAFGAALGGW 389
Cdd:cd17332 297 ILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLaDVIDygelktgkRREGIFYSVMTFFRKLGLALAGALVGL 376
|
250 260 270
....*....|....*....|....*....|....
gi 1093448552 390 V-IASGYGYRAPALGGATLAMLAIFIALPTIVLY 422
Cdd:cd17332 377 IlSLAGYVANAAAQSASALNGIRLLIAVLPAVLL 410
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-345 |
1.22e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.15 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 47 VALSVGAFGIGVtefvamgLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGAT 126
Cdd:cd17475 6 AAASLVAQGIPA-------LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 127 VWAGtlgSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAF 206
Cdd:cd17475 79 ALVG---SYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 207 VAVIGLIA--FVSLWFAVPHMNRMPKTRPMDELSALVT----PQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENH 280
Cdd:cd17475 156 AGLVSILAavLFWLFYREPPAASAATESASTLLRSLKEvlrnRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 281 IWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLL 345
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLL 300
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
48-221 |
1.55e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 43.71 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 48 ALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIgngATV 127
Cdd:COG2807 219 LLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGL---AGL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 128 WAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRgkMVALSGVGLSVATVIGVPAAQVLGQIY----GWRSA 203
Cdd:COG2807 296 LGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAE--AAALSGMAQSVGYLLAALGPLLVGALHdatgSWTAA 373
|
170
....*....|....*...
gi 1093448552 204 FAFVAVIGLIAFVSLWFA 221
Cdd:COG2807 374 LLLLAALAVLMLVAGLLA 391
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
53-416 |
2.79e-04 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 42.74 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 53 AFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIP-RRRMLLLLMAAFTIGNGATVWAgt 131
Cdd:pfam06779 2 TVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGAsRLRPALLAGLLATVLLLLAMAA-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 132 LGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVAL--SGVGLSVA-TVIGVPAAQVLGQIYGWR-SAFAFV 207
Cdd:pfam06779 80 TSSFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALlfAGVGIGIAlSGLLVPLGLQLGLGGSSLwYGAGVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 208 AVIGLIAFVSLWFAVPHMNRMPKTRPMDELSAlVTPQVLLTVAIGTVGFgGMFAVYTYITWTMTREAGMS--ENHIWIvl 285
Cdd:pfam06779 160 SAVLTLAVFPLLPRRAPRHASAPAPAAKPLQR-SLPLWILTLAYGLAGF-GYIITATFLPAMARDGFGGPaaAALFWS-- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 286 mAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAGRAQ 365
Cdd:pfam06779 236 -LFGLAAALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAP 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1093448552 366 TLAAALNQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:pfam06779 315 RRLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIVL 365
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
165-416 |
2.96e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 165 KPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVIGLIAFVSLWF--------AVPHMNRMPKTRPmDE 236
Cdd:cd17485 122 TPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSLAALYLLLLLPVLFlrelelpqQPPASERGAALKA-SL 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 237 LSALVTPQV---LLTVAIGTVGFGGMFAVYTyitwTMTREAGMSENHIWIVLMAYG-IGMVVGTYIGGWLSDRIGEW--- 309
Cdd:cd17485 201 RAFLRRPGTrwlLLFLLLYKLGEQGALAMLP----PFLVDRGFSLSQIGLLSGVGGsLVSIAGSLLGGYLLKRRGRRrll 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 310 ---GIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVPNLQTRLMDVAGRAQTLAA-ALNQAALNMANAFGAA 385
Cdd:cd17485 277 llgGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTDyTLLATVEVLGKLLFGS 356
|
250 260 270
....*....|....*....|....*....|.
gi 1093448552 386 LGGWvIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17485 357 LAGF-LADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
272-432 |
2.98e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.95 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 272 REAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSVLVP 351
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 352 NLQTRLMDVAGRAQTLAAA-LNQAALNMANAFGAALGGwVIASGYGYRAPALGGATLAMLAIFIALPTIVLYRRSQAKKA 430
Cdd:cd17325 104 AAMALIADIAPPEERGRAMgIFSSAIGLGFLIGPLLGG-LLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
..
gi 1093448552 431 ER 432
Cdd:cd17325 183 VS 184
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
106-346 |
3.43e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.51 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 106 IPRRRML---LLLMAAftigngATVWAGTLGSFEAV--------MVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVA 174
Cdd:cd17369 71 IGRKKTLvltLLLMGI------ATFLIGLLPTYAQIgilapillVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 175 L----SGVGLSVATVIGVPAAQVLGQ----IYGWRSAFAFVAVIGLIAFV-------SLWFAVPHMNRMPKTRPMDELSA 239
Cdd:cd17369 145 FpqlgAPVGLLLATGVFLLLSALLSDeaflSWGWRIPFLLSAVLVAVGLYirlrleeTPVFRRAKEAGQVVRAPLVEVLR 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 240 LVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWGIMVALVLMV 319
Cdd:cd17369 225 RHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLA 304
|
250 260 270
....*....|....*....|....*....|
gi 1093448552 320 IMLSVFYF---TSQNAVLGTINFLLIGLLG 346
Cdd:cd17369 305 ALFAFPFFwllDTGSTWLIVLAAVVVLGVL 334
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-183 |
7.69e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.50 E-value: 7.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 25 SSHRRPVPVQDDISDLRRILVIVALSVGAFGIGVTEFVAMGLLP-YIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLT 103
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPlYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 104 GSIPRRRMLLLLMAAFTIGNGATVWAGTLGsfeAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVA 183
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALAGSLW---LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
28-220 |
8.46e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.43 E-value: 8.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 28 RRPVPVQDDISDLRRILVIVALSVGAFGIGVTEFVAMGLLPYIAG-AFGRDEDAAGRMISMYALGVVVGAPLITVLTGSI 106
Cdd:COG2211 212 EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKyVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 107 PRRRMLLLLMAAFTIGNGATVWAGTlGSFEAVMVSRFIAGLPHGAYFSVAALVA-----ASLAKPGQR------GKMVAL 175
Cdd:COG2211 292 GKKKAFIIGLLLAALGLLLLFFLGP-GNLWLLLVLAALAGIGLGAILVLPWAMLadvvdYDEWKTGRRreglyfGIFTFA 370
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1093448552 176 SGVGLSVATVIGVP----------AAQVLGQIYGWRSAFAFVAVIG-LIAFVSLWF 220
Cdd:COG2211 371 IKLGQALAGALAGLllalfgyvagAAQSPSALTGIRLLFFLLPAVLlLLAALLLLF 426
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
85-220 |
1.04e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.18 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 85 ISMYALGVVVGAPLITVLTGSIP---------RRRMLLLlmAAFTIGNGATVwAGTLGSFEAVMVSRFIAGLPHGAYFSV 155
Cdd:cd17362 36 LSSLQSGLVVSGSLLGALLGSLVagalidrlgRRKELIL--AALLYLVGSLV-TGLAPSYPVLLVGRLIYGVGIGLAMHA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1093448552 156 AALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQ-IYGWRSAFAFVAVIGLIAFVSLWF 220
Cdd:cd17362 113 APVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADvVGGWRYMYGLAAPPALLLGIGMWF 178
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
42-187 |
1.10e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 42 RILVIVALSVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTI 121
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLIL 277
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1093448552 122 GNGATVWAGTLGSFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIG 187
Cdd:pfam07690 278 AALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
50-322 |
1.30e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 40.72 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 50 SVGAFGIGVTEFVAMGLLPYIAGAFGRDEDAAGR---MISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGAT 126
Cdd:cd17360 3 GIGGFLFGYDTGVISGALLYIKDDLGEVVLSTGWqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 127 VWAGTlgsFEAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLS----VATVIGVPAAQVLGqiyGWRS 202
Cdd:cd17360 83 AAAPN---KEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITggqfVAYVINGAFSYLPG---GWRW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 203 AFAFVAVIGLIAFVSLWFaVPHMNRMPKTRpmDELSALVTPQVLLTVA-IGTVgfggmfavyTYITWTMTREAGMSENHI 281
Cdd:cd17360 157 MLGLAAVPAVLQFIGLLF-LPESPRWPSTR--RALIVGCGLQAFQQFSgINTV---------MYYSATILQMAGFKDNQN 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1093448552 282 WIVLMAYGIGM-VVGTYIGGWLSDRIGE--------WGIMVALVLMVIML 322
Cdd:cd17360 225 AIWLSLIVAGTnFIFTIVGMYLIDKFGRrklllislFGVIVALVVLAVWL 274
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
79-344 |
1.45e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 40.68 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 79 DAAGRMISMYA-LGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATvwaGTLGSFEAVMVSRFIAGLPHGAYFSVAA 157
Cdd:PRK12307 52 DMEGAFLATAAfIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLS---GLASGVIMLTLSRFIVGMGMAGEYACAS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 158 LVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFaFVAVIGLIAFVSLWFAVP-------------- 223
Cdd:PRK12307 129 TYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAF-FVGLLPVLLVIYIRARAPeskeweeaklsgkg 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 224 -HMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMSENHIWI--VLMAYGIGMVVGTYIGG 300
Cdd:PRK12307 208 kHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGLLPTYLAGEGFDTGVVsnLMTAAAFGTVLGNIVWG 287
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1093448552 301 WLSDRIG-EWGIMVALVLMVIMLSVFYFTSQNavlgtiNFLLIGL 344
Cdd:PRK12307 288 LCADRIGlKKTFSIGLLMSFLFIFPLFRIPQD------NYLLLGA 326
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
65-337 |
1.76e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.25 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 65 GLLPYIAGAFGRDEDA--AGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLLMAAFTIGNGATVWAGtlgSFEAVMVSR 142
Cdd:cd17315 18 GALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAP---NVWVLIVGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 143 FIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSG----VGLSVATVIGVPAAqvLGQIYGWRSAFAFVAVIGLIAFVSL 218
Cdd:cd17315 95 FLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQlmitFGILLAYLLGLALS--LSPPGWWRLMFALAAVPALLQLLLM 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 219 WFavphmnrMPKTRPmdelsalvtpqvlLTVAIGTVG---FGGMFAVYTYITwTMTREAGMSENHIWIVLmAYGIGMVVG 295
Cdd:cd17315 173 FF-------LPESRA-------------LLVGVGLQLlqqLTGINAVMYYAP-TIFKSAGGGTASILASI-IVGVVNLLA 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1093448552 296 TYIGGWLSDRIGE-----WGIMVALVLMVIMLSVFYFTSQNAVLGTI 337
Cdd:cd17315 231 TLVAIRLVDKVGRrplllIGFAGMAASLLLLAIAFLLPALAKAAGWL 277
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
85-220 |
2.11e-03 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 40.29 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 85 ISMYALGVVVGAPLITVLTGSIPRRRMLLL-----LMAAFTIGNGATVwagtlGSFEAVMVSRFIAGLPHGAYFSVAALV 159
Cdd:cd17432 56 VSIFPLGGLFGSLLVGPLVIRLGRKGTLLLnnifaIVAAILMGLSKIA-----KSFEMIIVGRFLVGINAGISLNVVPMY 130
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1093448552 160 AASLAKPGQRGkMVALS-----GVGLSVATVIGVPaaQVLGQIYGWRSAFAFVAVIGLIAFVSL-WF 220
Cdd:cd17432 131 LGESAPKNLRG-AVGLVpaifiTLGILLGQVLGLR--ELLGNEEGWPLLLALTGVPALLQLLTLpFF 194
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
49-322 |
7.90e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 38.51 E-value: 7.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 49 LSVGAFGIGvteFVAMGLLPYIAGAFGrdeDAAGRMISMyalgvVVGAPLITVLTGsiprrrMLLLLMAAFTIGNGATVw 128
Cdd:cd17368 41 LTFATFGVG---FFMRPIGAIVLGAYA---DRIGRKPAM-----TLTLAIMALGTL------LIALAPTYATIGIAAPL- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 129 agtlgsfeAVMVSRFIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIG----------VPAAQVlgQIY 198
Cdd:cd17368 103 --------LVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGalvgyllsltLTAEAL--AEW 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 199 GWRSAFAFVAVIGLIAF-----VSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTRE 273
Cdd:cd17368 173 GWRIPFFIGLLIIPLGLwlrrsLEETEAFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVTFYFTTVYTPTYAKTV 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1093448552 274 AGMSENHIWIVLMAYGIGMVVGTYIGGWLSDRIGEWG-IMVALVLMVIML 322
Cdd:cd17368 253 LGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPvLLVITLAALVTL 302
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
66-346 |
8.08e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.13 E-value: 8.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLT-GSIPRRRML--LLLMAAFTIGNGatvWAGTLGSFEAVMvsr 142
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSdRSNPRVFLPigLILCAIVNLFFG---FSTSLWVMAALW--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 143 FIAGLPHGAYFSVAALVAASLAKPGQRGKMVALSGVGLSVATVIGVPAAQV-LGQIYGWRSAFAFVAVIGLI-AFVSLWF 220
Cdd:TIGR00881 91 ALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIvSLICFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 221 ------------AVPHMNRMPKTRPMDELSALVTPQVLLTVA--------IGTVGFGGMFAVYTYITWT---MTREAGMS 277
Cdd:TIGR00881 171 lrdspqscglppAEEMPNEEPDGDAEKKEEELTKKQIFLQYVllnkvlwyISLGYVFVYVVRTGILDWSplyLTQEKGFS 250
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1093448552 278 -ENHIWIVLMaYGIGMVVGTYIGGWLSDRI-----GEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLG 346
Cdd:TIGR00881 251 kEKASWAFTL-YELGGLVGTLLAGWLSDKLfngrrGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLV 324
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
198-344 |
8.36e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 38.29 E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 198 YGWRSAFAFVAVIGLIAFVSLWFAVPHMNRMPKTRPMDELSALVTPQVLLTVAIGTVGFGGMFAVYTYITWTMTREAGMS 277
Cdd:cd17370 153 GNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLS 232
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1093448552 278 EnhiWIVLMAYGIGMVVGT---YIGGWLSDRIGEWGIMVA-LVLMVIMLSVFYFTSQNAVLGtINFLLIGL 344
Cdd:cd17370 233 A---ALIPLLYALFNLVYAlaaYPAGRLSDRIGRKKLLILgYLSLALAYLGFALGSSLWLLL-LGFILWGL 299
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
66-416 |
9.47e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 38.16 E-value: 9.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 66 LLPYIAGAFGRDEDAAGRMISMYALGVVVGAPLITVLTGSIPRRRMLLLlmAAFTIGNGATVWAGTLGSFEAVMVSRFIA 145
Cdd:cd17314 25 FYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMAL--AGIMVLAGYTYLSYVFNSFPLSYACFVFI 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 146 GLPHGAYFSVAALVAASLAkPGQRGKMVALSGVGLSVATVIGVPAAQVLGQIYGWRSAFAFVAVigLIAFVSLWFAVPHM 225
Cdd:cd17314 103 GAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGI--LAAIVLSVVSLLGF 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 226 NRMP---------KTRPMDELSALVTPQV-LLTVAIGTVGFGGMFAVYTYITWTMTREaGMSENHIWIVLMAYGIGMVVG 295
Cdd:cd17314 180 KEPPdnqarlhvqKKKTQTMGEIFRDKVFwILFIAIFLVLIGGFLFIANMASLVRSLQ-LDAPSFVTKLMSIYGLFNAFG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093448552 296 TYIGGWLSDRIGEWGIMVALVLMVIMLSVFYFTSQNAVLGTINFLLIGLLGSV---LVPNLQTRLMDVAGRAQTLAAA-L 371
Cdd:cd17314 259 RLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSyggLFTVYPATVSTVFGTESFATLYgI 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1093448552 372 NQAALNMANAFGAALGGWVIASGYGYRAPALGGATLAMLAIFIAL 416
Cdd:cd17314 339 LLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
|
|
| |
