|
Name |
Accession |
Description |
Interval |
E-value |
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
21-447 |
9.28e-79 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 254.27 E-value: 9.28e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 21 RWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGF 100
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 101 SSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSI 180
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 181 FLINIPVVIFAIIGTLIFAPPNQPNPAKRWDFLTSLYAMLAMLGLVSLIKE-LAGHRSSTVIVAAIACGLVGAVLFQRRQ 259
Cdd:PRK14995 164 FLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTaLKGFLSLWVTSLTLLTGALLLGLFIRTQ 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 260 ARLTEPLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVG 339
Cdd:PRK14995 244 LAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 340 FRTLISGGFLLNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLIT 419
Cdd:PRK14995 324 LRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLG 403
|
410 420
....*....|....*....|....*...
gi 1093476953 420 VAITGSLLPMFYAlftpvdASISLTDAL 447
Cdd:PRK14995 404 IAIFGLLLSRSYS------ASIRLPAGL 425
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
28-460 |
3.36e-62 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 207.41 E-value: 3.36e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAF 107
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 108 APHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPV 187
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 188 VIFAIIGTlifappnqpnpakrwdfltslyamlamlglvslikelaghrsstvivaaiacglvgavlfqrrqarltepli 267
Cdd:cd17321 160 GLVALLLA------------------------------------------------------------------------ 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 268 dfsvfrsRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGG 347
Cdd:cd17321 168 -------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 348 FLLNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLL 427
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
410 420 430
....*....|....*....|....*....|...
gi 1093476953 428 PMFYALFTPVDASISLTDALHTpALNDGARAGL 460
Cdd:cd17321 321 TAGLSANLGDSGVAALLSAAAA-AFAAGFHLAF 352
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
28-427 |
3.61e-40 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 148.88 E-value: 3.61e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAF 107
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 108 APHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPV 187
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIY-PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 188 VIFAIIGTlifappnqpnpakrwdfltslyamlamlglvslikelaghrsstvivaaiacglvgavlfqrrqarltePLI 267
Cdd:cd17503 160 GILALLLA---------------------------------------------------------------------PLL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 268 DFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGG 347
Cdd:cd17503 171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 348 FLLNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLL 427
Cdd:cd17503 251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
23-434 |
9.07e-36 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 139.05 E-value: 9.07e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 23 IFLAI-ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFS 101
Cdd:TIGR00711 1 LLLTIvLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 102 SLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIF 181
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIY-PPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 182 LINIPVVIFAIIGTLIFAPPNQPNPAKRWDFLTslyAMLAMLGLVSLIKELA-----GHRSSTVIVAAIACGLVGAVLFQ 256
Cdd:TIGR00711 160 LINVPIGIIVVVVAFFILPRDKPAASENFDFLG---LLLLSVGLGSLLYGLSegperGWFDSNEILILSITGLVAIIAFV 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 257 RRQARLTEPLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLH 336
Cdd:TIGR00711 237 VWELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 337 RVGFRTLISGGFLLNAIGLAGMYYGVSSD-NFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFG 415
Cdd:TIGR00711 317 KIDPRKLVTIGLILYAVGFYWRAFTFTPDtPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLG 396
|
410
....*....|....*....
gi 1093476953 416 TLITVAITGSLLPMFYALF 434
Cdd:TIGR00711 397 GSIGTALITTILTNRTQFH 415
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-415 |
1.53e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 121.62 E-value: 1.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 15 PTSVTHRWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVG 94
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 95 LTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEH 174
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV-PPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 175 FWWGSIFLINIPVVIFAIIGTLIFAPPNQPnpakrwdfltslyamlamlglvslikelaghrsstvivaaiacglvgavl 254
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRP-------------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 255 fqRRQARLTEPLidFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMV 334
Cdd:COG2814 191 --AARARLRGSL--RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 335 LHRVGFRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEF 414
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
.
gi 1093476953 415 G 415
Cdd:COG2814 344 G 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
12-311 |
3.61e-29 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 116.45 E-value: 3.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 12 ATPPTSVTHRWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMF 91
Cdd:COG0477 3 STDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 92 LVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFL 171
Cdd:COG0477 83 LIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 172 LEHFWWGSIFLINIPVVIFAIIGTLIFappnqpnPAKRWDFLTSLYAMLAMLGLVSLIKELAGHRSSTVIVAAIACGLVG 251
Cdd:COG0477 162 VAALGWRWIFLINAPLGLLALVLRLRL-------PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 252 AVLFQRRQARLTEPLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPL 311
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
15-430 |
5.20e-26 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 110.59 E-value: 5.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 15 PTSVthRWIfLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVG 94
Cdd:PRK10504 5 PDSV--RWQ-LWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 95 LTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMP-ATLALLRETfhhPRE-LATAIGIWSATATLGAAAGPVVGGFLL 172
Cdd:PRK10504 82 IVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPvGRLTVMKIV---PREqYMAAMTFVTLPGQVGPLLGPALGGLLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 173 EHFWWGSIFLINIPVVIFAIIGTLIFApPNQPNPAKRWDFltSLYAMLAmLGLVSLIKELAGHR----SSTVIVAAIACG 248
Cdd:PRK10504 159 EYASWHWIFLINIPVGIIGAIATLMLM-PNYTMQTRRFDL--SGFLLLA-VGMATLTLALDGSKglglSPLAIAGLVAVG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 249 LVGAVLFQRRQARLTEPLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVG 328
Cdd:PRK10504 235 VVALLLYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMK 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 329 VIGGMVLHRVGFRTLISGGFLLNAI--------GLAGMYYgvssdnfpLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSK 400
Cdd:PRK10504 315 RIVVQVVNRFGYRRVLVATTLGLALvsllfmlvALLGWYY--------LLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNL 386
|
410 420 430
....*....|....*....|....*....|
gi 1093476953 401 AGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:PRK10504 387 ASSGNSLLSMIMQLSMSIGVTIAGLLLGLF 416
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-423 |
7.52e-24 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 102.26 E-value: 7.52e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 31 GLLLIGIDNSVLYTALPVLREQLHTTELEGlWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPH 110
Cdd:cd17502 4 ALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 111 AWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPVVIF 190
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLV-PPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 191 AIIGtlifappnqpnpakrwdfltslyamlamlglvslikelaghrSSTVIVAAIACGLVGAVLFqrrqarlteplidfs 270
Cdd:cd17502 162 ALAL------------------------------------------LRTILLSSIFGFLFGGALF--------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 271 vfrsrmfsggVLAAALAMFvlagaelmttqrFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVG-FRTLISGGFL 349
Cdd:cd17502 185 ----------GLIYYLPLY------------FQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTI 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093476953 350 LNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAIT 423
Cdd:cd17502 243 LMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAIT 316
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-436 |
2.00e-22 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 98.80 E-value: 2.00e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 29 SAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFA 108
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 109 PHAWALVIARGCLGLGAAtMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPVv 188
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA-VFPLAFALVREEF-PPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPV- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 189 ifaiigtlifappnqpnpakrwdfltslyamlamlglvslikelaghrsstVIVAAIACglvgavlfqrrqarltePLID 268
Cdd:cd17504 159 ---------------------------------------------------AVLLAALV-----------------PLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 269 FSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQ----ISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLI 344
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 345 SGGFLLNAIGLAGMYYGVSSdnFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITG 424
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
410
....*....|..
gi 1093476953 425 SLLPMFYALFTP 436
Cdd:cd17504 329 AILTTYTVSITS 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-418 |
4.05e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 94.95 E-value: 4.05e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAF 107
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 108 APHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPV 187
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIA-PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 188 VIFAIIGTLIFAPPNQPNPAKRWDFLTSLYAMLAMLGLVSLIkelaghrsstvivaaIACGLVGAVLfqrrqarltepli 267
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRL---------------LALFLAIFVL------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 268 dfsvfrsrMFSGGVLAAALAMFVlagAELMttqrfqisvGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGG 347
Cdd:cd17325 212 --------AFAFGALEPFLPLYA---AELG---------GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1093476953 348 FLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLI 418
Cdd:cd17325 272 LLLSAVALLLLPL---ATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-418 |
2.12e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.48 E-value: 2.12e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALP-VLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAA 106
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 107 FAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIP 186
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 187 VVIFAIIGTLIFAPPNQPNPAKrwdfltslyamlamlglvslikelaghrsstvivaaiacglvgavlfQRRQARLTEPL 266
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPK-----------------------------------------------PAEEARLSLIV 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 267 IDFSVFRSRMFSggVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISG 346
Cdd:pfam07690 193 AWKALLRDPVLW--LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1093476953 347 GFLLNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLI 418
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-427 |
4.54e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 88.77 E-value: 4.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 21 RWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGF 100
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 101 SSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSI 180
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 181 FLIN-IPVVIFAIIGTLIFAppnqpnpakrwdfltslyamlamlglvslikelaghrsstvivaaiacglvgavlfqrrq 259
Cdd:COG2271 167 FLILgLPGLLLALLRFWLLA------------------------------------------------------------ 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 260 arlteplidfsvfrsrmfsggvLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVG 339
Cdd:COG2271 187 ----------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLG 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 340 --FRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTL 417
Cdd:COG2271 245 rrRKLVLAIGLLLAALALLLLAL---LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410
....*....|
gi 1093476953 418 ITVAITGSLL 427
Cdd:COG2271 322 LGPLLVGYLL 331
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
26-426 |
1.47e-16 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 81.15 E-value: 1.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 26 AIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAA 105
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 106 AFAPHAWALVIARGCLGLGAATMMPATLALLRETFHHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFlini 185
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 186 pvvifaiigtlifappnqpnpakrwdfltslYAMLAMLGLVSLIKELAGHRSSTVIVAAIACGlvgavlfqrrqarltep 265
Cdd:cd17476 157 -------------------------------WFLAILAAIVAVAAIFWTSPSFIAVLLAVFLG----------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 266 lidFSVFRSRMFsggvlaaalamfvlagaelMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLIS 345
Cdd:cd17476 189 ---WASFGIWVF-------------------YATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMA 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 346 GGFLLNAIG---LAGMYygVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAI 422
Cdd:cd17476 247 ISMVAFLVGpilFATMP--VHQTYWAQAFPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGI 324
|
....
gi 1093476953 423 TGSL 426
Cdd:cd17476 325 AGTV 328
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
25-407 |
1.94e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 77.61 E-value: 1.94e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 25 LAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLA 104
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 105 AAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHHPrELATAIGIWSATATLGAAAGPVVGGFLLEhFWWGSIFLIn 184
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGG-ERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFL- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 185 IPVVIFAIIGTLIFAPPNQPNPAKRWDFLTSLyamlamlglvsLIKELAGHRSSTVIVAAIACGLVGAVLFqrrqarlte 264
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKEKAKSSSATKLR-----------DLKKALRGRGLLTFLVSAFLYFFLYFAF--------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 265 plidfsvfrsrmfsggvlaaalamfvLAGAELMTTQRFQISvgytPLDAGLLVATAALASLPVGVIGGMVLH-RVGFRTL 343
Cdd:cd17474 218 --------------------------LTYLPFLLELLYGIS----PIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRI 267
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093476953 344 ISGGFLLNAIGLAGMyygVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAM 407
Cdd:cd17474 268 LVIGLLLYALSLLLL---GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
45-429 |
3.89e-15 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 76.85 E-value: 3.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 45 ALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLG 124
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 125 AATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFlinipvVIFAIIGTLIFAppnqp 204
Cdd:cd17320 101 AAAGSVVARAIVRDLY-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF------VFLALLGLLLLL----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 205 npakrwdfltslyamLAMLGLVSLIKELAGHRSSTVIVAAIacglvGAVLFQRRqarlteplidfsvFRSRMFSGGVLAA 284
Cdd:cd17320 169 ---------------LVLLFLPETLPEEKRKPLLSSLLRAY-----KRVLKNRR-------------FLGYALALGLSFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 285 ALAMFVLAGAELMTTQrfqisVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGM--YYGV 362
Cdd:cd17320 216 GLFAYLAAAPFIYIEQ-----LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllAALL 290
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1093476953 363 SSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAIT----GSLLPM 429
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGllpnGTALPM 361
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
28-436 |
6.88e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 70.15 E-value: 6.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAF 107
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 108 APHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPV 187
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF-PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 188 VIFAIIGTLIFAPPNQPNPAKRwdfltslyamlamlglvslikelaghrsstvivaaiacglvgAVLFQRRQARLTEPLi 267
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESAR------------------------------------------AKNEEASSKSVLKLL- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 268 dFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFR-TLISG 346
Cdd:cd06174 197 -KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLI 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 347 GFLLNAIGLAGMYYGvssDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSL 426
Cdd:cd06174 276 GLLLMALGLALLLLA---PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
410
....*....|
gi 1093476953 427 LPMFYALFTP 436
Cdd:cd06174 353 LAATFGLTGA 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-427 |
4.13e-12 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 67.60 E-value: 4.13e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 21 RWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGF 100
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 101 SSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSI 180
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF-PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 181 FLINIPVVIFAIIGTLIFA--PPNQPNPAKRWDFLTSLYAMlamlglvslikelaghRSSTVIVAAIACGLVgavlfqrr 258
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLrdPPAGAAAAAKASLRDQLEAL----------------RDPRFWLLSLLYFGT-------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 259 qarlteplidfsvfrsrMFSGGVLAAALAMFvlagaelmttqrFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRV 338
Cdd:COG2223 218 -----------------FGSFIGFSSWLPPY------------LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 339 GFRTLISGGFLLNAIGLAGMYYgvSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLI 418
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLAL--ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
....*....
gi 1093476953 419 TVAITGSLL 427
Cdd:COG2223 347 GPLLFGALL 355
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
40-427 |
9.22e-12 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 67.27 E-value: 9.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 40 SVLYTALPVLREQLHTTELEGlWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARG 119
Cdd:cd06179 15 TLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 120 CLGLGAAT--MMPATLALLRETFHHPrelaTAIGIWSATATLGAAAGPVVGGFLLEHFW--WGSIFLINIPVVIFAIIGT 195
Cdd:cd06179 94 LIGIGAGTqgLGAAVASELVPNKYRG----LVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFNALALILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 196 LIF-APPNQPNP--------AKRWDFLTSLyamLAMLGLVSLIK--ELAGHR---SSTVIVAAIACGLVGAVLFQRRQAR 261
Cdd:cd06179 170 FFFyHPPPRPQLhgsstrqkLKRLDWVGLF---LLIAGLVLFLLglSWGGNPypwSSAHVIAPLVIGGVLLIAFGLYEWK 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 262 LTE--PLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVG 339
Cdd:cd06179 247 GTKdgLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIK 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 340 -FRTLISGGFLLNAIGLAGMyYGVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLI 418
Cdd:cd06179 327 hIKWQLVAGFVLFTAFLALL-ALITPDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAV 405
|
....*....
gi 1093476953 419 TVAITGSLL 427
Cdd:cd06179 406 GTAIFTSIL 414
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
62-427 |
9.34e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 9.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 62 WIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFH 141
Cdd:cd17473 39 LLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 142 HPrELATAIGIWSATATLGAAAGPVVGGFLLEHFWWG--SIFLINIPVVIFAIIgtLIFAPPNQPNPAKRWDFLTSlyam 219
Cdd:cd17473 119 GE-ERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRApfLVYLLALPVLILVLL--FLPEPARKSKSAASPGAATA---- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 220 lamlglvslikelagHRSSTVIVAAIAcglvgavlfqrrqarlteplidfsvfrsrmfsggvLAAALAMFVLAGAELMTT 299
Cdd:cd17473 192 ---------------AALPWKRVLPIY-----------------------------------FLAFLAMLLFYVIPIQLP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 300 QRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGA 379
Cdd:cd17473 222 FLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLAL---ASGLWVVLLGAILAGL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1093476953 380 GAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLL 427
Cdd:cd17473 299 GFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
27-427 |
1.92e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.57 E-value: 1.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 27 IISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAA 106
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 107 FAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIP 186
Cdd:cd17324 83 LAPSFALLLLARALAGLAHGGFWAIAAAYAADLV-PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 187 VVIFAIIGTLIFAPPNQPNPAKRWDFLTSLYAMLamlglvslikelaghRSSTVIVAAIACGLVGAVLFqrrqarltepl 266
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLL---------------RNPRLRLAYLITFLLFGGFF----------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 267 IDFSVFRSRMFSGGvlaaalamfvlagaelmttqrfqisvGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISG 346
Cdd:cd17324 216 ALYTYLAPFLTDVP--------------------------GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 347 GFLLNAIGLAGMYYGvssDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKaGMAAAMESVSYEFGTLITVAITGSL 426
Cdd:cd17324 270 LLLLAAALLLLTLLG---PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLV 345
|
.
gi 1093476953 427 L 427
Cdd:cd17324 346 L 346
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
21-193 |
2.72e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 58.74 E-value: 2.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 21 RWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGF 100
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 101 SSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSI 180
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170
....*....|....
gi 1093476953 181 FLI-NIPVVIFAII 193
Cdd:cd17319 160 FIIeGLLGLLLAVL 173
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-199 |
1.49e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.43 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 24 FLAIISAGLLLIGIDNSVLYTALPV-LREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSS 102
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 103 LAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHhPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFL 182
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVP-PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
170
....*....|....*..
gi 1093476953 183 INIPVVIFAIIGTLIFA 199
Cdd:cd17325 359 AAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-412 |
3.17e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 55.65 E-value: 3.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 12 ATPPTSVTHRWIFLAIISAGLLLIGIDNSVLYTA----LPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGH 87
Cdd:COG2807 3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSvgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 88 RKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhhPRELATAIGIWSATATLGAAAGPVV 167
Cdd:COG2807 83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF--PDRVGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 168 GGFLLEHFWWGSIFLINIPVVIFAIIGTLIFAPPNQPNPAkrwdfltslyamlamlglvslikelaghrsstvivAAIAC 247
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-----------------------------------AAPAA 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 248 GLVGAVLFQRRQARLTeplidfsvfrsrMFSGGVLAAALAMFVLAGAELMttqrfqiSVGYTPLDAGLLVATAALASLPV 327
Cdd:COG2807 206 ASLRSLWRSPLAWLLT------------LFFGLQSLLYYAVVAWLPPILR-------DAGLSAATAGLLLSLFQLAGIPG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 328 GVIGGMVLHRVG-FRTLISGGFLLNAIGLAGMYYGVSSdnfpLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSK--AGMA 404
Cdd:COG2807 267 SLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGS----LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAeaAALS 342
|
....*...
gi 1093476953 405 AAMESVSY 412
Cdd:COG2807 343 GMAQSVGY 350
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
33-430 |
4.34e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 54.91 E-value: 4.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 33 LLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAW 112
Cdd:cd17489 6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 113 ALVIARGCLGLGAATMMPATLALLREtFHHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLInipvvifai 192
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVAD-IIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV--------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 193 igtlifappnqpnpakrwdfltSLYAMLAMLGLVSLIKElaghrsstvivaaiacglvgavlfqrRQARLTEPLIDFSVF 272
Cdd:cd17489 156 ----------------------AAVLALLALLLVFLVKD--------------------------PPPVAAEEAEAGTRA 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 273 RSRMFSGGVLAAALAMFVLAGAelmttqrFQISVGYTPL--------DAGLLVATAALASLPVGVIGGMVLHRVGFRTLI 344
Cdd:cd17489 188 FRRLVEKKVLPPALILFLASIA-------YGAISTFLPLyaaergisNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVI 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 345 SGGFLLNAIGLAGMYYGvssDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITG 424
Cdd:cd17489 261 IPGLLLLALGLLLLSFA---GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG 337
|
....*.
gi 1093476953 425 SLLPMF 430
Cdd:cd17489 338 LVAELF 343
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
79-201 |
4.35e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 52.27 E-value: 4.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATAT 158
Cdd:TIGR00880 19 GLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY-PPEERGVALGLMSAGIA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1093476953 159 LGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIGTLIFAPP 201
Cdd:TIGR00880 98 LGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-193 |
1.64e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 50.43 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 15 PTSVTHRWIFLAIISAGLLLI-GIDNSVLYTALPVLREQLHTTELEGLWIINA--YPLVISALLLGTgtLGDRIGHRKMF 91
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMdGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAglIGMAFGALFFGP--LADRIGRRRVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 92 LVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLREtFHHPRELATAIGIWSATATLGAAAGPVVGGFL 171
Cdd:TIGR00895 86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
|
170 180
....*....|....*....|....
gi 1093476953 172 LEHFWWGSIFLIN--IPVVIFAII 193
Cdd:TIGR00895 165 IPVFGWRSLFYVGgiAPLLLLLLL 188
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
219-424 |
1.95e-06 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 50.38 E-value: 1.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 219 MLAMLGLVSLIKELAGHRSST----VIVAAIACGLVGAVLFQRRQARLT-EPLIDFSVFRSRMFSGGVLAAALAMFVLAG 293
Cdd:cd17322 224 LTAGLGLILVPLTLAGGAKSKwknsSIIAMIVLGGVLLVAFLLWEAKFAkYPFLPFRLLKDRTILAACLIDFFYFFSYYI 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 294 AELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVG-FRTLISGGFLLNAIGLAGMY-YGVSSDNFPLMI 371
Cdd:cd17322 304 FSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIrYRGGSGSHGGII 383
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1093476953 372 AGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITG 424
Cdd:cd17322 384 GALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISG 436
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
212-427 |
2.24e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 2.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 212 FLTSLYAMLAMLGLVSLIKELAGHRSSTVIVAAIACGLVGAV------LFQRRQARLTEPLIDF-----SVFRSRMFSGG 280
Cdd:COG2211 154 AFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLaflltfFGTKERPVPEEEKVSLkeslkALLKNRPFLLL 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 281 VLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYY 360
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093476953 361 gVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAP-------RSKAGMAAAMESVSYEFGTLITVAITGSLL 427
Cdd:COG2211 314 -LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
307-430 |
4.58e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 48.72 E-value: 4.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 307 GYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYGVSsdnFPLMIAGLILLGAGAGSVMS 386
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVS---YWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1093476953 387 VSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
282-430 |
5.54e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 5.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 282 LAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYg 361
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF- 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1093476953 362 vsSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:pfam07690 82 --ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
78-430 |
5.63e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 5.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 78 TGTLGDRIGHRKMFLV-----GLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHhPRELATAIGI 152
Cdd:cd06173 54 AGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVP-KEQLVRANAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 153 WSATATLGAAAGPVVGGFLLEHFWWGSIFLINipVVIFAIIGTLIFAPPNQPNPAKRwdfltslyamlamlglvslikel 232
Cdd:cd06173 133 NSLATQLARIIGPALGGLLVALLGPGGAFAIN--ALSFLLSALLLLFIRRPPPAAPG----------------------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 233 aghRSSTVIVAAIACGLvgavlfqrrqarlteplidFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLD 312
Cdd:cd06173 188 ---ESSSLLLRDLREGL-------------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 313 AGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAI 392
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNVPLNTLL 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 1093476953 393 IGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:cd06173 323 QLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
63-229 |
1.03e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 63 IINAYPLVISALLLGTGTLGDRIGHRKMFLV-GLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATlaLLRETFH 141
Cdd:cd17490 36 ILGAYGISQMLLRIPLGILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFT--VLYASYF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 142 HPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINipvVIFAIIGTLIFAPPNQPNPAKRwDFLTSLYAMLA 221
Cdd:cd17490 114 PPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLA---ALAGVLGFILSLFIKEERREKK-PVLTELKELLS 189
|
....*...
gi 1093476953 222 MLGLVSLI 229
Cdd:cd17490 190 VLKDKKLL 197
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
281-430 |
1.49e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 46.89 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 281 VLAAALAMFVLAGAELMTT---QRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAG 357
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLpalPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093476953 358 MYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:COG2814 92 CAL---APSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
307-430 |
4.94e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 45.63 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 307 GYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMS 386
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1093476953 387 VSSTAIIGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
313-443 |
5.75e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 45.30 E-value: 5.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 313 AGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYYgvsSDNFPLMIAGLILLGAGAGSVMSVSSTAI 392
Cdd:cd17329 37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF---AHSPWLFAIALVLTGFGGGLFEPASEAMI 113
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1093476953 393 IGSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMFYALFTPVDASISL 443
Cdd:cd17329 114 ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFL 164
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
281-392 |
1.37e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 281 VLAAALAMFVLAGAELMTT--QRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAI-GLAG 357
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPAlpAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIgGVAG 82
|
90 100 110
....*....|....*....|....*....|....*
gi 1093476953 358 MYygvsSDNFPLMIAGLILLGAGAGSVMSVSSTAI 392
Cdd:cd17473 83 LF----LDSLYALLASRALLGIGVAGIMTLATALI 113
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
239-430 |
1.90e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 239 TVIVAAIACGLVGAVLFQRRQARLTEPLIDFSVFRS-----RMFSGGVLAAALAMFVLAGAeLMTTQRFQISVGYTPLDA 313
Cdd:cd17370 162 AAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKlpkafWLYLLAVALFALGNFSFAFL-ILRAQELGLSAALIPLLY 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 314 GLLVATAALASLPVGVIGGmvlhRVGFRTLISGGFLLNAIGLAGMyygVSSDNFPLMIAGLILLGAGAGSVMSVSSTAII 393
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSD----RIGRKKLLILGYLSLALAYLGF---ALGSSLWLLLLGFILWGLYMGAQESIERAAVA 313
|
170 180 190
....*....|....*....|....*....|....*..
gi 1093476953 394 GSAPRSKAGMAAAMESVSYEFGTLITVAITGSLLPMF 430
Cdd:cd17370 314 DLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
28-407 |
2.09e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 43.70 E-value: 2.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 28 ISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAF 107
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 108 APHAWALVIARGCLGLGAATMMPATLALLRETFHHPRelATAIGIWSATATLGAAAGPVVGGFLLEHFWwgsifliNIPV 187
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLASQAAGGRR--GLAMSIFSVGGNLGFALGPLIAAALVALFG-------GLGL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 188 VIFAIIGTLIFAppnqpnpakrwdfltslyamLAMLGLVSLIKELAGHRSSTVIVAAIACGLVGAVLFqrrqarltepLI 267
Cdd:cd17478 152 LILLIIPGLAVA--------------------LLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLL----------LL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 268 DFSVFRSRMFSGgvLAAALAMFVlagaelmttqrfqISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRTLISGG 347
Cdd:cd17478 202 IIVFLRSWVLSS--LTTFLPFYL-------------VQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIAS 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 348 FLLNAIGLAGMYYGvssdNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSkAGMAAAM 407
Cdd:cd17478 267 LLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFASFPVTVVLAQELLPGN-VGLASGL 321
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
79-198 |
2.79e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhhPRELATAI-GIWSATA 157
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKIT--PKEVAGRIfGYNQSFQ 338
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1093476953 158 TLGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIGTLIF 198
Cdd:cd17391 339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-201 |
4.48e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 4.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 22 WIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRK--MFLVGLTIFG 99
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 100 FSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHhPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGS 179
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP-KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|..
gi 1093476953 180 IFLINIPVVIFAIIGTLIFAPP 201
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRE 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
70-194 |
5.13e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 5.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 70 VISALLLGTgtLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAA---TMMPATLALLRetfhHPREL 146
Cdd:cd17370 248 ALAAYPAGR--LSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGaqeSIERAAVADLV----PAELR 321
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1093476953 147 ATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIG 194
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-473 |
5.16e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.15 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 17 SVTHRWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLT 96
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 97 IFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLREtfhHPRELATAIgiwsatatlgaaagpvvggFLLEHFW 176
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA---LGPETAASR-------------------LNLLHAF 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 177 WGsiflinIPVVIFAIIGTLIFAppnqpnpakrWDFLTSLYAMLAMLGLVSLIkelaghrsstviVAAIACGLVGAVLFQ 256
Cdd:COG0738 140 FS------LGALLGPLLGGLLIL----------LGLSLSWHLPYLILAVLLLL------------LALLFLRSKLPEIEE 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 257 RRQARLTEPLIDFSVFRSRMFSGGVLAAALAMFVLAGAELMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLH 336
Cdd:COG0738 192 EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLK 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 337 RVGFRTLISGGFLLNAIGLAGMyygVSSDNFPLMIAGLILLGAGAGSVMSVSSTAIIGSAPRSKAGMAAAMESVSYeFGT 416
Cdd:COG0738 272 RFGPVRLLRLSALLAAVGLLLA---LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGG 347
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1093476953 417 LITVAITGSLlpmfyalftpvdasisltdalhtpalndGARAGLDSSYLAILIILAV 473
Cdd:COG0738 348 AIGPPLIGFL----------------------------ADAFGLRAAFLVPLVCYLL 376
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
36-198 |
5.49e-04 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 42.32 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 36 GIDnsvLY-TALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWAL 114
Cdd:PRK10473 18 GID---MYlVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 115 VIARGCLGLGAATMMPATLALLRETFhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFlinipvVIFAIIG 194
Cdd:PRK10473 95 LAGRFLQGIGAGCCYVVAFAILRDTL-DDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF------YTMAAMG 167
|
....
gi 1093476953 195 TLIF 198
Cdd:PRK10473 168 ILVL 171
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
25-201 |
6.19e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.18 E-value: 6.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 25 LAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLwiinaypLVISALLLGTGT-------LGDRIGHRKMFLVGLTI 97
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVAN-------LGVSLFVLGFGLgpliwapLSELYGRRPVYLVSLFI 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 98 FGFSSLAAAFAPHAWALVIARGCLGLGAATMM---PATLALLREtfhhPRELATAIGIWSATATLGAAAGPVVGGFLLEH 174
Cdd:cd17323 74 FVIFQIGCALAPNIAMLIILRFLQGFFGSSPLaigAGTIADLFT----PEERGKAMGVYSLGPLLGPALGPIIGGFITQS 149
|
170 180
....*....|....*....|....*..
gi 1093476953 175 FWWGSIFLINIPVVIFAIIGTLIFAPP 201
Cdd:cd17323 150 LGWRWIFWFLAIISGFCLILIFLFLPI 176
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
313-404 |
9.31e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 9.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 313 AGLLVATAALASLPVGVIGGMVLHRVGFRTLISGGFLLNAIGLAGMYygvSSDNFPLMIAGLILLGAGAGSVMSVSSTAI 392
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA---LVGSYPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90
....*....|..
gi 1093476953 393 IGSAPRSKAGMA 404
Cdd:cd17475 110 MRWFPPRERGLA 121
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
24-134 |
9.94e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 41.40 E-value: 9.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 24 FLAIISA-GLLLIGIDNSVLYTALPVLREQLHTTE-LEGLwiinayplVISALLLGT-------GTLGDRIGHRKMFLVG 94
Cdd:cd17359 1 LISLVAAlGGLLFGYDTGVINGALPFLQTDFNLTPfLEGL--------VVSSALLGAaigalfaGRLADRFGRRKTLLIS 72
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1093476953 95 LTIFGFSSLAAAFAPHAWALVIARGCLGLG---AATMMPATLA 134
Cdd:cd17359 73 AVLFFISALGSAFSPNFTIFIIARIIGGLAvggASALVPMYIA 115
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
79-199 |
2.54e-03 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 39.88 E-value: 2.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLREtFHHPRELATAIGIWSATAT 158
Cdd:cd17365 55 GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE-YAPARRRSLAVTLMFCGYP 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1093476953 159 LGAAAGPVVGGFLLEHFWWGSIFLIN-IPVVIFAII--GTLIFA 199
Cdd:cd17365 134 LGAALGGFLAAALIPAFGWRSVFLLGgVPPLILLPLlrGTLLLW 177
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
78-152 |
2.62e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 39.99 E-value: 2.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1093476953 78 TGTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHHPRELATAIGI 152
Cdd:cd17383 50 SGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGI 124
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
27-196 |
2.74e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.88 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 27 IISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLlgTGTLGDRIGHRKMFLVGLTIFGFSSLAAA 106
Cdd:cd17489 198 PPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPF--SGKLSDRKGPKTVIIPGLLLLALGLLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 107 FAPHAWALVIARGCLGLGAATMMPATLAL-LRETfhHPRELATAIGIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINI 185
Cdd:cd17489 276 FAGSPWMLLLAAVLYGLGFGLLFPALQALaVDLV--PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
170
....*....|.
gi 1093476953 186 PVVIFAIIGTL 196
Cdd:cd17489 354 VVVLLALVLYI 364
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
79-221 |
2.79e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.89 E-value: 2.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATmmPATLALLRETFhHPRELATAIGIWSATAT 158
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVMALLADLT-REENRTKAMALIGASIG 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093476953 159 LGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIGTLIFAPPNQPNPAKRWDFLTSLYAMLA 221
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLK 192
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
79-254 |
3.05e-03 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 39.89 E-value: 3.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGC--LGLGAATMMPATLallretfhhPR------ELATAI 150
Cdd:PRK11652 64 GPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIqgLGTGVGGVMARTL---------PRdlyegtQLRHAN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 151 GIWSATATLGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIGTLIFAPPNQPNPAKRWDFLTSLYAMLAMLG----LV 226
Cdd:PRK11652 135 SLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRfncyLL 214
|
170 180
....*....|....*....|....*...
gi 1093476953 227 SLIKELAGhrssTVIVAAIACGLVGAVL 254
Cdd:PRK11652 215 MLIGTLAG----IAVFEACSGVLMGAVL 238
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-154 |
3.57e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 2 TSTDHAASTRATPPTSVTHRWIFLAIISAGLLLIGIdNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTL 81
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGF-FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093476953 82 GDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHhPRELATAIGIWS 154
Cdd:COG2814 267 ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP-PEARGRASGLYN 338
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
79-204 |
8.20e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 38.72 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 79 GTLGDRIGHRKMFLVGLTIFGFSSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhhprELATAIGIWSA--- 155
Cdd:PRK11043 62 GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRY----PAQKANRVFATimp 137
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1093476953 156 TATLGAAAGPVVGGFLLEHFWWGSIFLINIPVVIFAIIGTLIFAPPNQP 204
Cdd:PRK11043 138 LVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKA 186
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-196 |
9.45e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 21 RWIFLAIISAGLLLIGIDNSVLYTALPVLREQLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGF 100
Cdd:cd06174 203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 101 SSLAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFHhPRELATAIGIWSATATLGAAAGPVVGGFLL-EHFWWGS 179
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP-PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTG 361
|
170
....*....|....*..
gi 1093476953 180 IFLINIPVVIFAIIGTL 196
Cdd:cd06174 362 AFLVLAVLLLLAAILLL 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-382 |
9.63e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.35 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 25 LAIISAGLLLIGIDNSVLYTALPVLRE--QLHTTELEGLWIINAYPLVISALLLGTGTLGDRIGHRKMFLVGLTIFGFSS 102
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 103 LAAAFAPHAWALVIARGCLGLGAATMMPATLALLRETFhhpreLATAIGIWSatatlgaaagpvvgGFLLEHFWWGsifl 182
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFA-----PSKRRGFAL--------------GLLQSGWALG---- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 183 inipvVIFAIIGTLIFAPPNQPNPAKRWDFLTSlyamlAMLGLVSLIKelaghRSSTVIVAAIacglvgavlfqrrqarl 262
Cdd:cd17316 138 -----ALLAALVASLLIPLLSGDWGWRILFLIG-----ALPALLALLL-----RRRTLLLILL----------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093476953 263 teplidfsvfrsrmfsggVLAAALAMFVLAgaeLMTTQRFQISVGYTPLDAGLLVATAALASLPVGVIGGMVLHRVGFRT 342
Cdd:cd17316 186 ------------------WFFISFGYYGLT---TFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK 244
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1093476953 343 LISGGFLLNAIGLAGMYYGVSSDNFPLMIAGLILLGAGAG 382
Cdd:cd17316 245 TLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGG 284
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