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Conserved domains on  [gi|1094015747|ref|WP_071011825|]
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MULTISPECIES: GntR family transcriptional regulator [Cupriavidus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
18-230 2.41e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 163.94  E-value: 2.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  18 SAARPARKGPVEERMYHEIYDAIMEHRLPPRTKLTEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDE 97
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  98 AHDMFELRQMMERAVLEKVAGMRDArAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVS 177
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATP-ADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1094015747 178 RTTL-MIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHLGACADRVQ 230
Cdd:COG1802   161 RLRRyRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLL 214
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
18-230 2.41e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 163.94  E-value: 2.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  18 SAARPARKGPVEERMYHEIYDAIMEHRLPPRTKLTEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDE 97
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  98 AHDMFELRQMMERAVLEKVAGMRDArAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVS 177
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATP-ADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1094015747 178 RTTL-MIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHLGACADRVQ 230
Cdd:COG1802   161 RLRRyRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLL 214
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 100-222 2.98e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.48  E-value: 2.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  100 DMFELRQMMERAVLEKVAGMRDARAVVApLRKMVAAERQAFLSHDRP-TWIRLSAEFHTALAELSGNALLVNMMRRLVSR 178
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAA-LEALLDAMEAAAAAGDDLeEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1094015747  179 TTLMIASVEAPGNNACsfDEHEEILDALEQGDAALAQARMAHHL 222
Cdd:smart00895  80 LRRLRRLSLEAARRAL--DEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 100-220 1.34e-18

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 78.57  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747 100 DMFELRQMMERAVLEKVAGMRDArAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVSRT 179
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATD-EDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1094015747 180 -TLMIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAH 220
Cdd:pfam07729  80 rRLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 24-222 2.17e-15

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 73.13  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  24 RKGPVEER-MYHEIYD----AIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVD---------LEPNRGA 88
Cdd:PRK03837    5 RSRPIARKkLSEEVEErleqMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQishgerarvSRPSADT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  89 FIA----------SPSTDEAHDMFELRQMMERAvLEKVAGMRDARAVVAPLRKMVAAERQAFlsHDRPTWIRLSAEFHTA 158
Cdd:PRK03837   85 IIGqlsgmakdflSQSPDGLAHLKQARLFFESS-LARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRV 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1094015747 159 LAELSGN----ALLVNMMRRLVSRTTLMiasVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHL 222
Cdd:PRK03837  162 IAEIPGNpifmAIHEALLDWLIEARPEV---VILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHL 226
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 27-91 6.55e-13

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 61.69  E-value: 6.55e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1094015747  27 PVEERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIA 91
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
18-230 2.41e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 163.94  E-value: 2.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  18 SAARPARKGPVEERMYHEIYDAIMEHRLPPRTKLTEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDE 97
Cdd:COG1802     2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  98 AHDMFELRQMMERAVLEKVAGMRDArAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVS 177
Cdd:COG1802    82 IRELYEVRAALEGLAARLAAERATP-ADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1094015747 178 RTTL-MIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHLGACADRVQ 230
Cdd:COG1802   161 RLRRyRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLL 214
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
21-230 1.06e-32

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 118.88  E-value: 1.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  21 RPARKGPVEERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDEA- 98
Cdd:COG2186     1 KPIRRRSLAEQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  99 --------------HDMFELRQMMERAVLEKVAGMRDARAVVApLRKMVAAERQAFlsHDRPTWIRLSAEFHTALAELSG 164
Cdd:COG2186    81 dplalllalddaslRDLLEARLALEPEAARLAAERATDEDLAR-LEAALAEMEAAA--DDGEAFAEADLAFHRAIAEASG 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1094015747 165 NALLVNMMRRLVS-RTTLMIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHLGACADRVQ 230
Cdd:COG2186   158 NPLLALLLESLRElLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLR 224
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 100-222 2.98e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 80.48  E-value: 2.98e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  100 DMFELRQMMERAVLEKVAGMRDARAVVApLRKMVAAERQAFLSHDRP-TWIRLSAEFHTALAELSGNALLVNMMRRLVSR 178
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAA-LEALLDAMEAAAAAGDDLeEFAELDREFHRALAEAAGNPVLLELLESLRAR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1094015747  179 TTLMIASVEAPGNNACsfDEHEEILDALEQGDAALAQARMAHHL 222
Cdd:smart00895  80 LRRLRRLSLEAARRAL--DEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 100-220 1.34e-18

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 78.57  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747 100 DMFELRQMMERAVLEKVAGMRDArAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVSRT 179
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATD-EDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1094015747 180 -TLMIASVEAPGNNACSFDEHEEILDALEQGDAALAQARMAH 220
Cdd:pfam07729  80 rRLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 24-222 2.17e-15

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 73.13  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  24 RKGPVEER-MYHEIYD----AIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVD---------LEPNRGA 88
Cdd:PRK03837    5 RSRPIARKkLSEEVEErleqMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQishgerarvSRPSADT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  89 FIA----------SPSTDEAHDMFELRQMMERAvLEKVAGMRDARAVVAPLRKMVAAERQAFlsHDRPTWIRLSAEFHTA 158
Cdd:PRK03837   85 IIGqlsgmakdflSQSPDGLAHLKQARLFFESS-LARYAAEHATDEQIALLRKALERNSQSL--GDNAAFIRSDMEFHRV 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1094015747 159 LAELSGN----ALLVNMMRRLVSRTTLMiasVEAPGNNACSFDEHEEILDALEQGDAALAQARMAHHL 222
Cdd:PRK03837  162 IAEIPGNpifmAIHEALLDWLIEARPEV---VILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHL 226
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 27-91 6.55e-13

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 61.69  E-value: 6.55e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1094015747  27 PVEERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIA 91
Cdd:cd07377     1 PLYEQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
30-128 6.09e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 60.65  E-value: 6.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  30 ERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDEA-HDMFELRQM 107
Cdd:COG2188     8 LQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPlSRLTSFTEE 87

                          90       100
                  ....*....|....*....|.
gi 1094015747 108 MERAVLEKVAGMRDARAVVAP 128
Cdd:COG2188    88 LRARGREPSTRVLSAERVPAD 108
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 30-90 1.67e-09

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 52.62  E-value: 1.67e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1094015747  30 ERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFI 90
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 28-192 2.48e-07

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 50.15  E-value: 2.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  28 VEERMYHEIYDAIME--HRLPprtklTEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDEA------- 98
Cdd:PRK09990   12 VAERIERLIVDGVLKvgQALP-----SERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDasplmhl 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  99 --------HDMFELRQMMErAVLEKVAGMRDARAVVAPLR----KMVAAErQAFLSHDRPTWIRLSAEFHTALAELSGNA 166
Cdd:PRK09990   87 fssqprtlYDLLEVRALLE-GESARLAALRGTQADFVLITrryeEMLAAH-ENNKEIDPIEHARLDHAFHLAICEASHNP 164

                         170       180
                  ....*....|....*....|....*.
gi 1094015747 167 LLVNMMRRLvsrTTLMIASVEAPGNN 192
Cdd:PRK09990  165 VLVHTLQSL---TDLMLSSVFASVNN 187
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
33-90 1.76e-06

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 44.10  E-value: 1.76e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1094015747   33 YHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFI 90
Cdd:smart00345   2 AERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10225 PRK10225
Uxu operon transcriptional regulator;
28-222 2.89e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 46.94  E-value: 2.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  28 VEERMYHE----IYDAIME------HRLPPrtkltEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFI---ASPS 94
Cdd:PRK10225    6 SAQRPYQEvgamIRDLIIKtpynpgERLPP-----EREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldsSGSH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  95 TDEAHDM--------FEL---RQMMERAVLEkVAGMRDARAVVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELS 163
Cdd:PRK10225   81 NTDSPDAnvcndagpFELlqaRQLLESNIAE-FAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEAT 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1094015747 164 GNALLVNMMRRlvsrttlmiaSVEAPGNNACSFD----------------EHEEILDALEQGDAALAQARMAHHL 222
Cdd:PRK10225  160 HNSMLVELFRQ----------SWQWRENNPMWIQlhshlddslyrkewlgDHKQILAALIKKDARAAKLAMWQHL 224
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 40-230 3.74e-06

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 46.68  E-value: 3.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  40 IMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTD--EAHDMFELRQMMERA----- 111
Cdd:PRK10421   15 IEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETwsEQNIVQPLKTLMADDpdysf 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747 112 -VLEKVAGMRDARAVVAPLRKMVAAE---RQAF---LSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRLVsrtTLMIA 184
Cdd:PRK10421   95 dILEARHAIEASTAWHAAMRATPGDKekiQLCFeatLSEDPDLASQADVRFHLAIAEASHNVVLLQTMRGFF---DVLQS 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1094015747 185 SVE--------APGNNACSFDEHEEILDALEQGDAALAQARMAHHLGACADRVQ 230
Cdd:PRK10421  172 SVKqsrqrmylVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIK 225
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 47-222 6.82e-06

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 45.66  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  47 PRTKLTEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASPSTDEAHDMFELRQMMErAVLEKVAGMRDARA-- 124
Cdd:PRK11534   27 PDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANME-AMLVSLAIARGGDEwe 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747 125 --VVAPLRKMVAAERQAFLSHDRPTWIRLSAEFHTALAELSGNALLVNMMRRL-----------VSRTTLMIASVEApgn 191
Cdd:PRK11534  106 adVLAKAHLLSKLEACDASEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLfdlaaryrfiwLRRTVLSVEMLED--- 182

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1094015747 192 nacSFDEHEEILDALEQGDAALAQARMAHHL 222
Cdd:PRK11534  183 ---KHDQHQTLTAAILARDTARASELMRQHL 210
PRK11402 PRK11402
transcriptional regulator PhoB;
36-93 4.20e-05

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 43.67  E-value: 4.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1094015747  36 IYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIASP 93
Cdd:PRK11402   18 LLDDIAQGVYQAGQQIpTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ 76
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
27-114 9.07e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 40.93  E-value: 9.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  27 PVEERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIAS--PSTDEAHDMFE 103
Cdd:COG1725    10 PIYEQIADQIKEAIASGELKPGDRLpSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEdaRELLEERREEF 89

                          90
                  ....*....|.
gi 1094015747 104 LRQMMERAVLE 114
Cdd:COG1725    90 LEEALRELVAE 100
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 22-111 5.70e-04

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 40.58  E-value: 5.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1094015747  22 PARKGPVEERMYHEIYDAIMEHRLPPRTKL-TEHSLCEIYATARHTVRKVLSRLAADGMVDLEPNRGAFIAS-------- 92
Cdd:COG1167     7 RDSSGPLYLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAArlpapapa 86

                          90
                  ....*....|....*....
gi 1094015747  93 PSTDEAHDMFELRQMMERA 111
Cdd:COG1167    87 PRAAAAVAAPALRRLLEAA 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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