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Conserved domains on  [gi|1098558324|ref|WP_071238639|]
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DHA2 family efflux MFS transporter permease subunit [Shewanella algae]

Protein Classification

efflux MFS transporter permease( domain architecture ID 1000855)

efflux MFS (major facilitator superfamily) transporter permease, similar to Escherichia coli multidrug efflux pump EmrB and Neisseria gonorrhoeae fatty acid resistance protein FarB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
efflux_EmrB super family cl31024
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 27-506 2.59e-107

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00711:

Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 328.95  E-value: 2.59e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  27 IAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVAS 106
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 107 LLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 187 NLPPGL--VVMAMLAYGLEKKPIlwdkLRNADYSGIVTMALGMGCLEVVLEEGNRKDWFGSDLIRNLAIIAAINICLFIW 264
Cdd:TIGR00711 162 NVPIGIivVVVAFFILPRDKPAA----SENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 265 IQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQK 344
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 345 VDGRYLAAFGFAMLALSYYMNSH---MTMDYAgpQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNL 421
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFtftPDTPFL--AIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 422 GGAFGIALVATLTDNLSRMHLAHIKETVPAVSAGAYEALNANAALLqaagsdpvTASAQAKALLAQTMTQQAYVQAYNDV 501
Cdd:TIGR00711 396 GGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALG--------NPEQQVYALIAQQITLHAFSIAINEI 467


                  ....*
gi 1098558324 502 FFIMG 506
Cdd:TIGR00711 468 FWMAT 472
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 27-506 2.59e-107

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 328.95  E-value: 2.59e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  27 IAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVAS 106
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 107 LLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 187 NLPPGL--VVMAMLAYGLEKKPIlwdkLRNADYSGIVTMALGMGCLEVVLEEGNRKDWFGSDLIRNLAIIAAINICLFIW 264
Cdd:TIGR00711 162 NVPIGIivVVVAFFILPRDKPAA----SENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 265 IQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQK 344
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 345 VDGRYLAAFGFAMLALSYYMNSH---MTMDYAgpQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNL 421
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFtftPDTPFL--AIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 422 GGAFGIALVATLTDNLSRMHLAHIKETVPAVSAGAYEALNANAALLqaagsdpvTASAQAKALLAQTMTQQAYVQAYNDV 501
Cdd:TIGR00711 396 GGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALG--------NPEQQVYALIAQQITLHAFSIAINEI 467


                  ....*
gi 1098558324 502 FFIMG 506
Cdd:TIGR00711 468 FWMAT 472
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-447 2.06e-98

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 302.57  E-value: 2.06e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd17503     2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGL 192
Cdd:cd17503    82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 193 VVMAMlayglekkpilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrksAP 272
Cdd:cd17503   162 LALLL-------------------------------------------------------------------------AP 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 273 LVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAA 352
Cdd:cd17503   169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 353 FGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVAT 432
Cdd:cd17503   249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328

                         410
                  ....*....|....*
gi 1098558324 433 LTDNLSRMHLAHIKE 447
Cdd:cd17503   329 LLTNRTQFHHSRLSE 343
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-424 4.36e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.11  E-value: 4.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  22 SRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALA 101
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 102 FIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWH 181
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 182 YLFYINLPPGLVVMAMLAYGLEKKPilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainicl 261
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESR------------------------------------------------------- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 262 fiwIQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRL 341
Cdd:COG2814   190 ---PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 342 MQKVDGRYLAAFGFAMLALSYYMnshMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNL 421
Cdd:COG2814   267 ADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                  ...
gi 1098558324 422 GGA 424
Cdd:COG2814   344 GGP 346
PRK10504 PRK10504
putative transporter; Provisional
 26-327 2.79e-28

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 117.53  E-value: 2.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  26 WIAVFGgligAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVA 105
Cdd:PRK10504   13 WIVAFG----FFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 106 SLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFY 185
Cdd:PRK10504   89 SLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 186 INLPPGLV-----VMAMLAYGLEKkpilwdklRNADYSGIVTMALGMGCLEVVLeEGNRKDWFGSDLIRNLAIIAAINIC 260
Cdd:PRK10504  169 INIPVGIIgaiatLMLMPNYTMQT--------RRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098558324 261 LFIWIQLRKSAPLVNLRLLGQRDFAISTLAYFL--LGAALFGaiYMIPLFLSQLHDYSPLEIGEVIMWM 327
Cdd:PRK10504  240 LYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAgrIGSGMLP--FMTPVFLQIGLGFSPFHAGLMMIPM 306
MFS_1 pfam07690
Major Facilitator Superfamily;
33-426 1.12e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 105.19  E-value: 1.12e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKE-IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSF 111
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 112 AWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPG 191
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 192 LVVMAMLAYGLEKKPILWDKLRNADYSGIVTmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfIWIQLRKSA 271
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIV----------------------------------------AWKALLRDP 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 272 PLVNLrllgqrdfaistLAYFLLGAALFGAIYMIPLFLSQLHdYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLA 351
Cdd:pfam07690 202 VLWLL------------LALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098558324 352 AFGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFG 426
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 27-506 2.59e-107

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 328.95  E-value: 2.59e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  27 IAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVAS 106
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 107 LLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 187 NLPPGL--VVMAMLAYGLEKKPIlwdkLRNADYSGIVTMALGMGCLEVVLEEGNRKDWFGSDLIRNLAIIAAINICLFIW 264
Cdd:TIGR00711 162 NVPIGIivVVVAFFILPRDKPAA----SENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVV 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 265 IQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQK 344
Cdd:TIGR00711 238 WELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 345 VDGRYLAAFGFAMLALSYYMNSH---MTMDYAgpQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNL 421
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFtftPDTPFL--AIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQL 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 422 GGAFGIALVATLTDNLSRMHLAHIKETVPAVSAGAYEALNANAALLqaagsdpvTASAQAKALLAQTMTQQAYVQAYNDV 501
Cdd:TIGR00711 396 GGSIGTALITTILTNRTQFHHSQLTETINPVNPNFLSGYSQLAALG--------NPEQQVYALIAQQITLHAFSIAINEI 467


                  ....*
gi 1098558324 502 FFIMG 506
Cdd:TIGR00711 468 FWMAT 472
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 33-447 2.06e-98

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 302.57  E-value: 2.06e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd17503     2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGL 192
Cdd:cd17503    82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 193 VVMAMlayglekkpilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrksAP 272
Cdd:cd17503   162 LALLL-------------------------------------------------------------------------AP 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 273 LVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAA 352
Cdd:cd17503   169 LLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL 248

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 353 FGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVAT 432
Cdd:cd17503   249 AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328

                         410
                  ....*....|....*
gi 1098558324 433 LTDNLSRMHLAHIKE 447
Cdd:cd17503   329 LLTNRTQFHHSRLSE 343
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 33-456 2.34e-45

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 163.11  E-value: 2.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd17321     2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGL 192
Cdd:cd17321    82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 193 VVMAMLayglekkpilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrksap 272
Cdd:cd17321   162 VALLLA-------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 273 lvnlrllgqRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAA 352
Cdd:cd17321   168 ---------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLV 238

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 353 FGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVAT 432
Cdd:cd17321   239 AGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGA 318

                         410       420
                  ....*....|....*....|....
gi 1098558324 433 LTDNLSRMHLAHIKETVPAVSAGA 456
Cdd:cd17321   319 LLTAGLSANLGDSGVAALLSAAAA 342
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
22-424 4.36e-37

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 140.11  E-value: 4.36e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  22 SRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALA 101
Cdd:COG2814     5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 102 FIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWH 181
Cdd:COG2814    85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 182 YLFYINLPPGLVVMAMLAYGLEKKPilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainicl 261
Cdd:COG2814   165 WVFLVNAVLALLALLLLLRLLPESR------------------------------------------------------- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 262 fiwIQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRL 341
Cdd:COG2814   190 ---PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 342 MQKVDGRYLAAFGFAMLALSYYMnshMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNL 421
Cdd:COG2814   267 ADRFGRRRLLLIGLLLLALGLLL---LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                  ...
gi 1098558324 422 GGA 424
Cdd:COG2814   344 GGP 346
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 33-429 6.19e-35

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 133.84  E-value: 6.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGAtLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd17502     2 MLALFLAALDQTIVATALPTIVAEFGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGL 192
Cdd:cd17502    81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 193 VVMAMLayglekkpilwdklrnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrksap 272
Cdd:cd17502   161 LALALL-------------------------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 273 lvnlrllgqRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVdGRY--L 350
Cdd:cd17502   167 ---------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKT-GRYkpL 236

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098558324 351 AAFGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIAL 429
Cdd:cd17502   237 IVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 53-454 1.63e-31

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 125.00  E-value: 1.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFfGGAL 132
Cdd:cd17504    22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 133 IPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMlayglekkpilwdkl 212
Cdd:cd17504   101 FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL--------------- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 213 rnadysgivtmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrksAPLVNLRLLGQRDFAISTLAYF 292
Cdd:cd17504   166 ----------------------------------------------------------VPLIDLRLLRRRNVLLANITAL 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 293 LLGAALFGAIYMIPLFLSQLHDY----SPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAAFGFAMLALSYYMnsHM 368
Cdd:cd17504   188 LAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLL--LA 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 369 TMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVATLtdnLSRMHLAHIKET 448
Cdd:cd17504   266 LLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI---LTTYTVSITSGG 342


                  ....*.
gi 1098558324 449 VPAVSA 454
Cdd:cd17504   343 VPTEGA 348
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 22-308 6.50e-30

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 118.76  E-value: 6.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  22 SRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALA 101
Cdd:COG0477     9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 102 FIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWH 181
Cdd:COG0477    89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWR 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 182 YLFYINLPPGLVVMAMLAYGLEKKPILWDKLRNADYSGIVTMALGMGCLEVVLEEGNRKDWFGSDLIRNLAIIAAINICL 261
Cdd:COG0477   169 WIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLL 248

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1098558324 262 FIWIQLRKSAPLVNLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLF 308
Cdd:COG0477   249 ALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
PRK10504 PRK10504
putative transporter; Provisional
 26-327 2.79e-28

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 117.53  E-value: 2.79e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  26 WIAVFGgligAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVA 105
Cdd:PRK10504   13 WIVAFG----FFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 106 SLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFY 185
Cdd:PRK10504   89 SLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFL 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 186 INLPPGLV-----VMAMLAYGLEKkpilwdklRNADYSGIVTMALGMGCLEVVLeEGNRKDWFGSDLIRNLAIIAAINIC 260
Cdd:PRK10504  169 INIPVGIIgaiatLMLMPNYTMQT--------RRFDLSGFLLLAVGMATLTLAL-DGSKGLGLSPLAIAGLVAVGVVALL 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098558324 261 LFIWIQLRKSAPLVNLRLLGQRDFAISTLAYFL--LGAALFGaiYMIPLFLSQLHDYSPLEIGEVIMWM 327
Cdd:PRK10504  240 LYLLHARNNNRALFSLKLFRTRTFSLGLAGSFAgrIGSGMLP--FMTPVFLQIGLGFSPFHAGLMMIPM 306
MFS_1 pfam07690
Major Facilitator Superfamily;
33-426 1.12e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 105.19  E-value: 1.12e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKE-IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSF 111
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 112 AWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPG 191
Cdd:pfam07690  82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 192 LVVMAMLAYGLEKKPILWDKLRNADYSGIVTmalgmgclevvleegnrkdwfgsdlirnlaiiaainiclfIWIQLRKSA 271
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIV----------------------------------------AWKALLRDP 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 272 PLVNLrllgqrdfaistLAYFLLGAALFGAIYMIPLFLSQLHdYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLA 351
Cdd:pfam07690 202 VLWLL------------LALLLFGFAFFGLLTYLPLYQEVLG-LSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL 268

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098558324 352 AFGFAMLALSYYMNSHMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFG 426
Cdd:pfam07690 269 LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
20-196 2.64e-22

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 98.40  E-value: 2.64e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  20 PGSRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNA 99
Cdd:COG2271     3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 100 LAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLS 179
Cdd:COG2271    83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162

                         170
                  ....*....|....*..
gi 1098558324 180 WHYLFYINLPPGLVVMA 196
Cdd:COG2271   163 WRAAFLILGLPGLLLAL 179
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 30-504 2.03e-18

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 88.07  E-value: 2.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  30 FGGLIGAFMAILDIQITNASMKEIQGSLGATlEEGSWISTAYLVAEMIAIPLSGWLSTgLSVRRYLLWNALAF-IVASLL 108
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSD-LFGRRWFFIGGNLLgVVGSIV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 109 CSFAWNLEAMIAFRALQGFfGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTE--HLSWHYLFYI 186
Cdd:cd06179    79 AGTAKSVNMLIGGQALIGI-GAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 187 NLppGLVVMAMLAYGL---------EKKPILWDKLRNADYSGIVTMALGMGCLEVVLE-EGNRKDWFGSDLIRNLAIIAA 256
Cdd:cd06179   158 NA--IFNALALILLFFfyhppprpqLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSwGGNPYPWSSAHVIAPLVIGGV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 257 INICLFIWIQLRKSAPLVNLRLLGQ-RDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVL 335
Cdd:cd06179   236 LLIAFGLYEWKGTKDGLLPPRLLFRgRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGA 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 336 PLVPRLMQKV-DGRYLAAFGFAMLALSYYMNSHMTMDYAGpQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTV 414
Cdd:cd06179   316 ILAGLLLTKIkHIKWQLVAGFVLFTAFLALLALITPDNKA-LAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 415 LNVVRNLGGAFGIALVATLTDNLSRMHLAhiKETVPAV-SAGAYEALNANAALLQAAGSDP-------VTASAQAKALLA 486
Cdd:cd06179   395 LGSARALGGAVGTAIFTSILSNRLSKNLP--ARVAPAAlEAGLPASSLPALLGALASGNIAaltavpgINPEIIAAATAA 472

                         490
                  ....*....|....*...
gi 1098558324 487 QtmtQQAYVQAYNDVFFI 504
Cdd:cd06179   473 L---KQAYADSFRYVWYA 487
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 56-438 3.47e-18

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 86.48  E-value: 3.47e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPL 135
Cdd:cd17325    25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 136 AFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYinlppglvVMAMLAyglekkpilwdklrna 215
Cdd:cd17325   105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFL--------VCAALA---------------- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 216 dysgIVTMALGMGCLEVVLEEGNRKDwfgsdlirnlaiiaainiclfiwiQLRKSAPLVNLRLLGQRDFAISTLAYFLLG 295
Cdd:cd17325   161 ----LLALVLALLLLPEPRPPPNKRA------------------------VSAARLRSGLRLLLRDRRLLALFLAIFVLA 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 296 AALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAAFGFAMLALSYYMNSHMTmdyAGP 375
Cdd:cd17325   213 FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT---SFW 289

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098558324 376 QMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVATLTDNLS 438
Cdd:cd17325   290 LLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 49-206 2.00e-17

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 84.16  E-value: 2.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  49 SMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFF 128
Cdd:cd17320    21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1098558324 129 GGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAYGLEKKP 206
Cdd:cd17320   101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETL 178
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 34-206 4.78e-17

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 82.60  E-value: 4.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  34 IGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAW 113
Cdd:cd17324     6 LAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 114 NLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLV 193
Cdd:cd17324    86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL 165

                         170
                  ....*....|...
gi 1098558324 194 VMAMLAYGLEKKP 206
Cdd:cd17324   166 AALLLWRLLPSLP 178
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 36-200 1.42e-16

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 81.46  E-value: 1.42e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  36 AFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNL 115
Cdd:cd17474     8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 116 EAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHlSWHYLFYinLPPGLVVM 195
Cdd:cd17474    88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFF--LLAALIPV 164


                  ....*
gi 1098558324 196 AMLAY 200
Cdd:cd17474   165 AFLAI 169
2_A_01_02 TIGR00880
Multidrug resistance protein;
69-199 4.43e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 74.99  E-value: 4.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  69 TAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEK 148
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1098558324 149 RAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLA 199
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLA 135
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 26-197 7.03e-16

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 79.15  E-value: 7.03e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  26 WIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVA 105
Cdd:cd17319     2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 106 SLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFY 185
Cdd:cd17319    82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI 161

                         170
                  ....*....|..
gi 1098558324 186 INLPPGLVVMAM 197
Cdd:cd17319   162 IEGLLGLLLAVL 173
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 33-435 4.16e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.08  E-value: 4.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHL--SWHYLFYINLPP 190
Cdd:cd06174    82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAAL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 191 GLVVMAMLAYGLEKKPilWDKLRNADYSGIVTMALGMgclevvleegnrkdwfgsdlirnlaiiaainiclfiwiqlrks 270
Cdd:cd06174   162 ALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLL------------------------------------------- 196

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 271 aplvnLRLLGQRDFAISTLAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGR-Y 349
Cdd:cd06174   197 -----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRkP 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 350 LAAFGFAMLALSYYMnshMTMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIAL 429
Cdd:cd06174   272 LLLIGLLLMALGLAL---LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348


                  ....*.
gi 1098558324 430 VATLTD 435
Cdd:cd06174   349 AGFLLA 354
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 22-200 4.19e-15

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 77.04  E-value: 4.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  22 SRRAWIAVFGGLigAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALA 101
Cdd:TIGR00710   2 SAKAFALLLGCL--SILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 102 FIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWH 181
Cdd:TIGR00710  80 FALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWH 159

                         170
                  ....*....|....*....
gi 1098558324 182 YLFYINLPPGLVVMAMLAY 200
Cdd:TIGR00710 160 AIFAFLSLAGILLSALIFF 178
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 20-202 4.28e-15

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 77.01  E-value: 4.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  20 PGSRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNA 99
Cdd:TIGR00895  10 PLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 100 LAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLS 179
Cdd:TIGR00895  90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169

                         170       180
                  ....*....|....*....|...
gi 1098558324 180 WHYLFYINLPPGLVVMAMLAYGL 202
Cdd:TIGR00895 170 WRSLFYVGGIAPLLLLLLLMRFL 192
PRK14995 PRK14995
SmvA family efflux MFS transporter;
56-445 1.65e-14

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 75.92  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAY-LVAEMIAIPLsGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIP 134
Cdd:PRK14995   35 TLGASGNELLWIIDIYsLVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAAMIVP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 135 LAFRLILECLPTEK-RAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAYGLEKKPILWDKLR 213
Cdd:PRK14995  114 ATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 214 NADYSGIVTMALgmgCLEVVLEEGNRKDWFGSDLIRNLAIIAAINICLFIWIQLRKSAPLVNLRLLGQRDFAISTLAYFL 293
Cdd:PRK14995  194 NLGHALMLIVAI---LLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDMRLFTHRIILSGVVMAMT 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 294 LGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAAFGFAMLALSYYMNShmTMDYA 373
Cdd:PRK14995  271 AMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMALSALSFYGLA--MTDFS 348

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1098558324 374 GPQMIASQVVRALGqpfIMVPIGILATMH-----LKPEQTPSASTVLNVVRNLGGAFGIALVATLtdnLSRMHLAHI 445
Cdd:PRK14995  349 TQQWQAWGLMALLG---FSAASALLASTSaimaaAPPEKAAAAGAIETMAYELGAGLGIAIFGLL---LSRSYSASI 419
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
23-206 4.57e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.52  E-value: 4.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  23 RRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAF 102
Cdd:COG2223     1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 103 IVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHY 182
Cdd:COG2223    81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160

                         170       180
                  ....*....|....*....|....
gi 1098558324 183 LFYINLPPGLVVMAMLAYGLEKKP 206
Cdd:COG2223   161 AFLILGILLLVVAVLAWLFLRDPP 184
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
53-205 7.29e-11

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 63.74  E-value: 7.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLS--TGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGG 130
Cdd:COG2271   207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSdrLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1098558324 131 ALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYInLPPGLVVMAMLAYGLEKK 205
Cdd:COG2271   287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL-LAALALLAALLALLLLRE 360
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 57-202 7.82e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 7.82e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  57 LGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLA 136
Cdd:cd17489    26 LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAA 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098558324 137 FRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYInlppgLVVMAMLAYGL 202
Cdd:cd17489   106 ATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV-----AAVLALLALLL 166
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 65-198 1.05e-09

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 60.29  E-value: 1.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  65 SWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECL 144
Cdd:cd17365    37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYA 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1098558324 145 PTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAML 198
Cdd:cd17365   117 PARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL 170
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 92-188 1.66e-09

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 59.51  E-value: 1.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  92 RRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLG 171
Cdd:cd17323    64 RPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIG 143

                          90
                  ....*....|....*..
gi 1098558324 172 GWLTEHLSWHYLFYINL 188
Cdd:cd17323   144 GFITQSLGWRWIFWFLA 160
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 29-197 2.84e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.77  E-value: 2.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  29 VFGGLIGAFMAILDIQITNASMKEI--QGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVAS 106
Cdd:cd17316     1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 107 LLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKR----AVGMALFGVTATFAPSIGPTLGGWLTEHLSWHY 182
Cdd:cd17316    81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRgfalGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160

                         170
                  ....*....|....*
gi 1098558324 183 LFYINLPPGLVVMAM 197
Cdd:cd17316   161 LFLIGALPALLALLL 175
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 65-200 3.23e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 3.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  65 SWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECL 144
Cdd:cd17473    38 PLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYF 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1098558324 145 PTEKRAVGMALFGVTATFAPSIGPTLGGWLTEhLSWHYLFYINLPPGLVVMAMLAY 200
Cdd:cd17473   118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLF 172
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 34-216 4.35e-09

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 58.54  E-value: 4.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  34 IGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAW 113
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 114 NLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGG-WLTEHLSWHYLFYInlpPGL 192
Cdd:TIGR00881  82 SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFIV---PGI 158

                         170       180
                  ....*....|....*....|....*.
gi 1098558324 193 --VVMAMLAYGLEKKPILWDKLRNAD 216
Cdd:TIGR00881 159 iaIIVSLICFLLLRDSPQSCGLPPAE 184
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
9-201 1.07e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 57.17  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324   9 ATAASQDDSYGPGSRRAW---IAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWL 85
Cdd:COG0738   190 EEEEEEAAGSAASLKSLLknpRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  86 STGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPtEKRAVGMALFGVTATFAPS 165
Cdd:COG0738   270 LKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLG-KRTAAAVSAVLIMGIVGGA 348

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1098558324 166 IGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAYG 201
Cdd:COG0738   349 IGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 65-165 1.32e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 56.43  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  65 SWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECL 144
Cdd:cd17317    28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1098558324 145 PTEKR-----------AVGMALFGVTATFAPS 165
Cdd:cd17317   108 GPKYRsfvgilfglfwALGYMLLALLAYLIRD 139
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 34-208 2.26e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 56.04  E-value: 2.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  34 IGAFMAILDIQITNASMKEIQGSLGATL--EEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSF 111
Cdd:cd17315     4 LGGLLFGYDLGVINGALLYIAKDLGFGLstSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSAL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 112 AWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATF----APSIGPTLGGWLTEhlSWHYLFYIN 187
Cdd:cd17315    84 APNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFgillAYLLGLALSLSPPG--WWRLMFALA 161

                         170       180
                  ....*....|....*....|.
gi 1098558324 188 LPPGLVVMAMLAYGLEKKPIL 208
Cdd:cd17315   162 AVPALLQLLLMFFLPESRALL 182
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 30-197 3.27e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 55.77  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  30 FGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLC 109
Cdd:cd17371     2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 110 SFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKR--AVG--MALFGVTATFAPSIGPTLGGWLTEHLSWHYLFY 185
Cdd:cd17371    82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRgkALGyvQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFL 161

                         170
                  ....*....|..
gi 1098558324 186 INLPPGLVVMAM 197
Cdd:cd17371   162 LGALPALLVLFI 173
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
95-199 6.17e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 54.92  E-value: 6.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  95 LLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWL 174
Cdd:PRK11102   59 ILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWL 138

                          90       100
                  ....*....|....*....|....*
gi 1098558324 175 TEHLSWHYLFYInlppgLVVMAMLA 199
Cdd:PRK11102  139 LVWFSWHAIFWV-----LALAAILA 158
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 54-179 1.55e-07

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 53.35  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  54 QGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGAlI 133
Cdd:cd17330    26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-V 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1098558324 134 PLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLS 179
Cdd:cd17330   105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG 150
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 57-199 4.83e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.81  E-value: 4.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  57 LGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLA 136
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098558324 137 FRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLA 199
Cdd:cd17325   310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 47-197 8.40e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 51.12  E-value: 8.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  47 NASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQG 126
Cdd:cd17312    23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1098558324 127 FFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYInlpPGLVVMAM 197
Cdd:cd17312   103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV---PGIVGLVV 170
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-200 8.90e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 51.27  E-value: 8.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  23 RRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLW-NALA 101
Cdd:cd06174   200 LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLiGLLL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 102 FIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLT-EHLSW 180
Cdd:cd06174   280 MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGL 359

                         170       180
                  ....*....|....*....|
gi 1098558324 181 HYLFYINLppGLVVMAMLAY 200
Cdd:cd06174   360 TGAFLVLA--VLLLLAAILL 377
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 41-206 1.27e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 50.70  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  41 LDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSvRRYLLWNALAF-IVASLLCSFAWNLEAMI 119
Cdd:cd17328    13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN-RKWILAVGILIwSAATLLSSFAPNFWQLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 120 AFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEH-LSWHYLFYINLPPGLVVMAML 198
Cdd:cd17328    92 LFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILL 171


                  ....*...
gi 1098558324 199 AYGLEKKP 206
Cdd:cd17328   172 LLFVREPP 179
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 25-186 2.30e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 2.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  25 AWIAVFGGLIGAFMAILdiqitnasmkeIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIV 104
Cdd:cd06173   218 ALFALLGGALTVLLPLL-----------AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 105 ASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLF 184
Cdd:cd06173   287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366


                  ..
gi 1098558324 185 YI 186
Cdd:cd06173   367 LL 368
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
22-207 3.00e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  22 SRRAW-IAVFGGLIGAFMAILdiqitNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNAL 100
Cdd:COG2807   214 SPLAWlLTLFFGLQSLLYYAV-----VAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 101 AFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRA---VGMAlFGVTATFApSIGPTLGGWLTEH 177
Cdd:COG2807   289 LLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAaalSGMA-QSVGYLLA-ALGPLLVGALHDA 366

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1098558324 178 L-SWHYLFYINLpPGLVVMAMLAYGLEKKPI 207
Cdd:COG2807   367 TgSWTAALLLLA-ALAVLMLVAGLLAGRPYV 396
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 27-198 3.93e-06

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 49.10  E-value: 3.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  27 IAVFGGLIGAFmailDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVAS 106
Cdd:cd17359     5 VAALGGLLFGY----DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 107 LLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKR--AVG----MALFGVTATFAP--SIGPTLGGWLTEHL 178
Cdd:cd17359    81 LGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRgrLVSlnqlMIVFGQLLAYIVnyLIANAGGADWLGAE 160

                         170       180
                  ....*....|....*....|
gi 1098558324 179 SWHYLFYINLPPGLVVMAML 198
Cdd:cd17359   161 GWRWMLGLEAIPAILFLLGM 180
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 33-187 6.13e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 48.41  E-value: 6.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  33 LIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA 112
Cdd:cd17476     4 SGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFS 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098558324 113 WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEK-RAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYIN 187
Cdd:cd17476    84 PNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPrKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 57-187 6.18e-06

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 48.37  E-value: 6.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  57 LGATLEEGSWISTAYLVAEMIAIPLSGWL-STGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPL 135
Cdd:cd17490   225 LGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPL 304

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1098558324 136 AFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYIN 187
Cdd:cd17490   305 LMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVI 356
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 73-186 7.58e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.31  E-value: 7.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  73 VAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPtEKRAVG 152
Cdd:cd17324   245 VAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLA 323

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1098558324 153 MALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:cd17324   324 SSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWV 357
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 21-186 9.48e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 47.94  E-value: 9.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  21 GSRRAWIAVFGGLIGAFMAILdIQITNASMKEIQG-SLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNA 99
Cdd:cd17477   182 SLRRLLRIAPLALLGAFVAGF-LEGAFYSLLPLYGlRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 100 LAFIVASLLCSFAWNLE-AMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHL 178
Cdd:cd17477   261 LLGALAALLLPLVPGLPlALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340


                  ....*...
gi 1098558324 179 SWHYLFYI 186
Cdd:cd17477   341 GPHGLFLF 348
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 79-200 1.43e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.21  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  79 IPLsGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGffGGALIPLAFRLILECLPTEKRAVGMALFGV 158
Cdd:cd17472    50 IPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG--SGAISSVVMALLADLTREENRTKAMALIGA 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098558324 159 TATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAY 200
Cdd:cd17472   127 SIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLF 168
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
11-199 2.31e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.79  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  11 AASQDDSYGPGSRRAWIAVFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLS 90
Cdd:COG2807     2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  91 VRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPtEKRAVGMALFGVTATFAPSIGPTL 170
Cdd:COG2807    82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGL 160

                         170       180
                  ....*....|....*....|....*....
gi 1098558324 171 GGWLTEHLSWHylfyinlpPGLVVMAMLA 199
Cdd:COG2807   161 TVPLAAALGWR--------GALAVWALLA 181
Sugar_tr pfam00083
Sugar (and other) transporter;
31-194 4.76e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 45.73  E-value: 4.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  31 GGLIGAFmAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCS 110
Cdd:pfam00083  16 TGVIGAF-LTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 111 FA---WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFapsiGPTLGGWLT-------EHLSW 180
Cdd:pfam00083  95 AAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITF----GILLAYIFGlglnktsNSDGW 170

                         170
                  ....*....|....
gi 1098558324 181 HYLFYINLPPGLVV 194
Cdd:pfam00083 171 RIPLGLQLVPALLL 184
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
71-207 4.90e-05

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 45.78  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  71 YLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRA 150
Cdd:PRK10473   47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1098558324 151 -VGMALFGVTATFaPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAYGL-EKKPI 207
Cdd:PRK10473  127 kVLSLLNGITCII-PVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILkETRPA 184
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
57-174 5.02e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 45.66  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  57 LGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA--WNLEAMIAFRALQGFFGGALIP 134
Cdd:COG2211   259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILV 338

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1098558324 135 LAFRLILECLP-----TEKRAVG--MALFGVTATFAPSIGPTLGGWL 174
Cdd:COG2211   339 LPWAMLADVVDydewkTGRRREGlyFGIFTFAIKLGQALAGALAGLL 385
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 56-186 5.45e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 45.62  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFI--VASLLCSFAWNLEAMIAFRALQGFFGGALI 133
Cdd:cd17352   212 SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLIlgLSLLAFPLATTYVGLIVFSVLFGFCSGSYS 291

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1098558324 134 PLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHL-SWHYLFYI 186
Cdd:cd17352   292 SLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTgDYDAAFYF 345
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 27-198 5.81e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 45.64  E-value: 5.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  27 IAVFGGLIGAFMAILDIQIT----NASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAF 102
Cdd:cd17358     2 LATFVANLGSFSFGIAVGWSspalPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 103 IVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRavgmALFGVTATFAPSIGPTLGGWLTEHLSWHY 182
Cdd:cd17358    82 ILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR----GALGSLNQLLVNIGILLGYVLGSFLPWRT 157

                         170
                  ....*....|....*..
gi 1098558324 183 LFYI-NLPPGLVVMAML 198
Cdd:cd17358   158 LALIgAIPPVVFLILLF 174
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 82-186 5.83e-05

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 45.30  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  82 SGWLSTGLSVRRYLLWNALAFIVASLLCSFA--WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVT 159
Cdd:cd17318    76 GGYLAEKYGAKRVLGYSILITALLTLLTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSG 155

                          90       100
                  ....*....|....*....|....*..
gi 1098558324 160 ATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:cd17318   156 SQFGTVIAMPLSGFLCESLGWPSIFYI 182
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 81-186 6.00e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 6.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  81 LSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTA 160
Cdd:cd17474   254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVR 333

                          90       100
                  ....*....|....*....|....*.
gi 1098558324 161 TFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:cd17474   334 FLGQAVGPLLFGLLLEIFGLSAPFLV 359
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 53-199 1.04e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEA--MIAFRALQGFFGG 130
Cdd:cd17316   204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPtlLLLLLFILSFFVG 283

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 131 ALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGW-LTEHLSWHYLFYINLPPGLVVMAMLA 199
Cdd:cd17316   284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALlLASTGGTGVPALILALLAIVALIVAL 353
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 53-186 1.20e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 44.48  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSV--RRYLLWNALAF-IVASLLCSFAWNLEAMIAFRALQGFFG 129
Cdd:cd17319   206 LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgaRRLVIIIGLLLaAVGLLLAYLTTSPVVAVILLSLAGFGI 285

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1098558324 130 GALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHL-SWHYLFYI 186
Cdd:cd17319   286 GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLF 343
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 68-162 1.31e-04

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 44.62  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  68 STAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTE 147
Cdd:TIGR00898 133 QSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212

                          90
                  ....*....|....*
gi 1098558324 148 KRAVGMALFGVTATF 162
Cdd:TIGR00898 213 QRAIVGTLIQVFFSL 227
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 53-198 1.66e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLlwnALAFIVASLLCS---FAWNLEAMIAFRALQGFFG 129
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLL---PLGPLLTGLGLSllgFAPNYWLLLLLVALAGIGS 98

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1098558324 130 GALIPLAFRLILEcLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAML 198
Cdd:cd17478    99 AAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLL 166
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 32-186 3.11e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.08  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  32 GLIGAFMAILDIQITNASmkeiqgslGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSF 111
Cdd:cd17333     9 GLTDALLGILGPSLEEAF--------NLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1098558324 112 AWNLEAMIAFRALQGFFGGALIPLAFRLILECLPtEKRAVGMALFGVTATFAPSIGPTLGGWL-TEHLSWHYLFYI 186
Cdd:cd17333    81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLI 155
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
65-184 3.42e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 43.00  E-value: 3.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  65 SWIS---TAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGF---FGGALIPLAFR 138
Cdd:PRK15402   48 EWVPtsmTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIglcFIGAVGYAAIQ 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1098558324 139 LILEclptEKRAVG-MALFGVTATFAPSIGPTLGGWLTEHLSWHYLF 184
Cdd:PRK15402  128 ESFE----EADAIKiTALMANVALLAPLLGPLVGAALIHVLPWRGMF 170
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 56-180 3.47e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 43.13  E-value: 3.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSV--RRYLLWNALAFIVASLL---CSFAWNLEAMIAFRALQGFFGG 130
Cdd:TIGR00881 246 EKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgrRGPLAVFFMALIIVSLLvywLNPAANPLMDLICLFALGFLVY 325

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1098558324 131 ALIPLAFRLILECLPteKRAVGMALfGVTATFAPSIGPTLG---GWLTEHLSW 180
Cdd:TIGR00881 326 GPQMLIGVIASELAP--KKAAGTAA-GFVGFFAYLGGILAGlplGYLADGFGW 375
MFS_1 pfam07690
Major Facilitator Superfamily;
29-168 4.56e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 4.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  29 VFGGLIGAFMAILDIQITNASMKEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASL- 107
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALg 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1098558324 108 --LCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGP 168
Cdd:pfam07690 282 llLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 81-186 4.98e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 42.54  E-value: 4.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  81 LSGWLSTGLSVRRYLLWNALAFIVASLLCSFA--WNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAVGMALfgV 158
Cdd:cd17380    53 LGGYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSI--V 130

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1098558324 159 TAtfAPSIGPTLGGWLT----EHLSWHYLFYI 186
Cdd:cd17380   131 TA--GSYLGTLLGGLIGplllEYYGWPSVFYF 160
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
53-186 5.68e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 5.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  53 IQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFA-WNLEAMIAFRALQGFFGGA 131
Cdd:COG2223   232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGG 311

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1098558324 132 LIPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEHL-SWHYLFYI 186
Cdd:COG2223   312 GNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLV 367
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 56-177 5.92e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 5.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALiPL 135
Cdd:cd17390    25 SLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQ-SL 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098558324 136 AFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEH 177
Cdd:cd17390   104 CKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
23-199 6.36e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 42.15  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  23 RRAWIAVFGG--LIGAFMAILDIQITnasmkEIQGSLGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNAL 100
Cdd:COG0738     7 RRALIAIYLLffLWGFATALWGPLIP-----ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 101 AFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILEcLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEH--- 177
Cdd:COG0738    82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLgls 160

                         170       180
                  ....*....|....*....|..
gi 1098558324 178 LSWHYLFYINLPPGLVVMAMLA 199
Cdd:COG0738   161 LSWHLPYLILAVLLLLLALLFL 182
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 57-177 9.41e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 9.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  57 LGATLEEGSWISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLA 136
Cdd:cd17329    30 LGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPAS 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1098558324 137 FRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWLTEH 177
Cdd:cd17329   110 EAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLY 150
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-186 1.29e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 41.10  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  73 VAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGaLIPLAFRLILECLPTEKRAVG 152
Cdd:cd17391    47 LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQTPKEKSGWA 125

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1098558324 153 MALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:cd17391   126 LGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
77-186 1.78e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 40.67  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  77 IAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGaLIPLAFRLILECLPTEKRAVGMALF 156
Cdd:PRK09874   69 IASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTL 147

                          90       100       110
                  ....*....|....*....|....*....|
gi 1098558324 157 GVTATFAPSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:PRK09874  148 STGGVSGALLGPLAGGLLADSYGLRPVFFI 177
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 73-186 3.77e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  73 VAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLPTEKRAvg 152
Cdd:cd17391   251 VSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAG-- 328

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1098558324 153 mALFGVTATF---APSIGPTLGGWLTEHLSWHYLFYI 186
Cdd:cd17391   329 -RIFGYNQSFqylGNVAGPLLGSAIAAHFGYRAVFVV 364
MFS_1 pfam07690
Major Facilitator Superfamily;
289-438 4.28e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 289 LAYFLLGAALFGAIYMIPLFLSQLHDYSPLEIGEVIMWMGFPQLLVLPLVPRLMQKVDGRYLAAFGFAMLALSYYMnshM 368
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL---L 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324 369 TMDYAGPQMIASQVVRALGQPFIMVPIGILATMHLKPEQTPSASTVLNVVRNLGGAFGIALVATLTDNLS 438
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 67-200 5.44e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.11  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  67 ISTAYLVAEMIAIPLSGWLSTGLsVRRYLLWNALAFIVASLLC-SFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLP 145
Cdd:cd17489   232 FFTVYAIALLLSRPFSGKLSDRK-GPKTVIIPGLLLLALGLLLlSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1098558324 146 TEKRAVGMALFGVTATFAPSIGPTLGGWLTEHLSWHYLFYINLPPGLVVMAMLAY 200
Cdd:cd17489   311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIF 365
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 66-173 5.71e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  66 WISTAYLVAEMIAIPLSGWLSTGLSVRRYLLWNALAFIVASLLCSFAWNLEAMIAFRALQGFFGGALIPLAFRLILECLP 145
Cdd:cd17477    35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114

                          90       100
                  ....*....|....*....|....*...
gi 1098558324 146 TEKRAVGMALFGVTATFAPSIGPTLGGW 173
Cdd:cd17477   115 NENRGRVLGLYSTVLGLGFALGPLLLAL 142
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 56-174 9.46e-03

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 38.53  E-value: 9.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098558324  56 SLGATLEEGSWISTAYLVAEMIAIPLSGWLS---TGLSVRRYLLWNALAFiVASLLCSFAWNLEAMIAFRALQGFFGGAL 132
Cdd:cd17423   234 ALGLGEYQAAFVVSVAAVADAVGRLFSGWLAdlgPLRLLHLLVLWTALTG-LSLLLLPLAKVYGSLLALAVAYGFCAGAL 312

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098558324 133 IPLAFRLILECLPTEKRAVGMALFGVTATFAPSIGPTLGGWL 174
Cdd:cd17423   313 APLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWL 354
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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