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Conserved domains on  [gi|1098696469|ref|WP_071277267|]
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MULTISPECIES: PAS domain-containing protein [Priestia]

Protein Classification

PAS and STAS_RsbR_RsbS_like domain-containing protein( domain architecture ID 13490941)

PAS and STAS_RsbR_RsbS_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13557 super family cl36263
histidine kinase; Provisional
 17-125 5.06e-41

histidine kinase; Provisional


The actual alignment was detected with superfamily member PRK13557:

Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 147.90  E-value: 5.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  17 ALDYTRAGLIITDPSLSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTKD 96
Cdd:PRK13557   35 AVETTRMPMIVTDPNQPDNPIVFANRAFLEMTGYAAEEIIGNNCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKD 114

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1098696469  97 NRPFWNELYIDPLWME--DKLYFVGVQKDIT 125
Cdd:PRK13557  115 GSSFWNALFVSPVYNDagDLVYFFGSQLDVS 145
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 145-253 4.58e-29

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


:

Pssm-ID: 132912  Cd Length: 109  Bit Score: 106.00  E-value: 4.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 145 STPIVPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITG 224
Cdd:cd07041     1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                          90       100
                  ....*....|....*....|....*....
gi 1098696469 225 ITPLLARKMGDLYVNFNDLTTFTHVKNAL 253
Cdd:cd07041    81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
 
Name Accession Description Interval E-value
PRK13557 PRK13557
histidine kinase; Provisional
 17-125 5.06e-41

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 147.90  E-value: 5.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  17 ALDYTRAGLIITDPSLSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTKD 96
Cdd:PRK13557   35 AVETTRMPMIVTDPNQPDNPIVFANRAFLEMTGYAAEEIIGNNCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKD 114

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1098696469  97 NRPFWNELYIDPLWME--DKLYFVGVQKDIT 125
Cdd:PRK13557  115 GSSFWNALFVSPVYNDagDLVYFFGSQLDVS 145
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 145-253 4.58e-29

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 106.00  E-value: 4.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 145 STPIVPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITG 224
Cdd:cd07041     1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                          90       100
                  ....*....|....*....|....*....
gi 1098696469 225 ITPLLARKMGDLYVNFNDLTTFTHVKNAL 253
Cdd:cd07041    81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
PAS COG2202
PAS domain [Signal transduction mechanisms];
10-129 6.68e-22

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 91.24  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  10 ELQFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQ 89
Cdd:COG2202     9 SERRLRALVESSPDAIIITDL---DGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGE 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098696469  90 ILNYTKDNRPFWNELYIDPLWMED--KLYFVGVQKDITEKVK 129
Cdd:COG2202    86 LRNRRKDGSLFWVELSISPVRDEDgeITGFVGIARDITERKR 127
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 34-126 2.82e-18

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 77.50  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  34 DNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIaaRSSITVQILNYTKDNRPFWNELYIDPLWMED 113
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREG--KAVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....*
gi 1098696469 114 K--LYFVGVQKDITE 126
Cdd:pfam13426  79 GelVGIIAILRDITE 93
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 149-231 6.17e-11

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 57.56  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 149 VPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEEsKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITGITPL 228
Cdd:COG1366     4 VEVRDGVLVLPLIGELDAARAPELREALLEALET-GARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82


                  ...
gi 1098696469 229 LAR 231
Cdd:COG1366    83 VAR 85
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 15-126 2.49e-10

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 60.30  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  15 QKALDYTRAGLIITDpsLSDNpIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYT 94
Cdd:TIGR02938   7 RQTVDQAPLAISITD--LKAN-ILYANDAFTRITGYTKEEIIGKNESVLSNHTTPPEVYQALWGSLAEQKPWAGKLLNRR 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1098696469  95 KDNRPFWNELYIDPLWME--DKLYFVGVQKDITE 126
Cdd:TIGR02938  84 KDGELYLAELTVAPVLNEagETTHFLGMHRDITE 117
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 147-252 2.74e-09

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 53.39  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 147 PIVPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITGIT 226
Cdd:pfam01740   2 PEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPS 81

                          90       100
                  ....*....|....*....|....*.
gi 1098696469 227 PLLARKMgDLYVNFNDLTTFTHVKNA 252
Cdd:pfam01740  82 PEVARTL-EKTGLDDIIKIFPTVAEA 106
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 24-124 2.13e-05

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 42.62  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  24 GLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTKDNRPFWNE 103
Cdd:cd00130     4 GVIVLDL---DGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|...
gi 1098696469 104 LYIDPL--WMEDKLYFVGVQKDI 124
Cdd:cd00130    81 VSLTPIrdEGGEVIGLLGVVRDI 103
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 12-59 1.79e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.92  E-value: 1.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1098696469   12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTN 59
Cdd:smart00091   1 ERLRAILESLPDGIFVLDL---DGRILYANPAAEELLGYSPEELIGKS 45
 
Name Accession Description Interval E-value
PRK13557 PRK13557
histidine kinase; Provisional
 17-125 5.06e-41

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 147.90  E-value: 5.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  17 ALDYTRAGLIITDPSLSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTKD 96
Cdd:PRK13557   35 AVETTRMPMIVTDPNQPDNPIVFANRAFLEMTGYAAEEIIGNNCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKD 114

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1098696469  97 NRPFWNELYIDPLWME--DKLYFVGVQKDIT 125
Cdd:PRK13557  115 GSSFWNALFVSPVYNDagDLVYFFGSQLDVS 145
PRK13559 PRK13559
hypothetical protein; Provisional
 15-129 6.29e-40

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 141.49  E-value: 6.29e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  15 QKALDYTRAGLIITDPSLSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYT 94
Cdd:PRK13559   46 EQAMEQTRMAMCITDPHQPDLPIVLANQAFLDLTGYAAEEVVGRNCRFLQGAATDPIAVAKIRAAIAAEREIVVELLNYR 125

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1098696469  95 KDNRPFWNELYIDPLWMEDK--LYFVGVQKDITEKVK 129
Cdd:PRK13559  126 KDGEPFWNALHLGPVYGEDGrlLYFFGSQWDVTDIRA 162
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 10-129 3.13e-39

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 144.21  E-value: 3.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  10 ELQFIQKALDYTRAGLIITDPSLSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQ 89
Cdd:PRK13558  146 DRRLKERALDEAPVGITIADATLPDEPLIYINDAFERITGYSPDEVLGRNCRFLQGEDTNEERVAELREAIDEERPTSVE 225

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098696469  90 ILNYTKDNRPFWNELYIDPLWMEDK--LYFVGVQKDITEKVK 129
Cdd:PRK13558  226 LRNYRKDGSTFWNQVDIAPIRDEDGtvTHYVGFQTDVTERKE 267
STAS_RsbR_RsbS_like cd07041
Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex ...
 145-253 4.58e-29

Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain of proteins related to RsbS and RsbR which are part of the "stressosome" complex that plays an important role in the regulation of the bacterial stress activated alternative sigma factor sigma-B. During stress conditions RsbS and RsbR are phosphorylated which leads to the release of RsbT, an activator of of the RsbU phosphatase, which in turn activates RsbV which leads to the release and activation of sigma factor B. RsbS is a single domain protein (STAS domain), while RsbR-like proteins have a well-conserved C-terminal STATS domain and a variable N-terminal domain. The STAS domain is also found in the C- terminal region of sulphate transporters and anti-anti-sigma factors.


Pssm-ID: 132912  Cd Length: 109  Bit Score: 106.00  E-value: 4.58e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 145 STPIVPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITG 224
Cdd:cd07041     1 STPIIPVWDGVLVLPLIGDLDDERAEQLQERLLEAISRRRARGVIIDLTGVPVIDSAVARHLLRLARALRLLGARTILTG 80

                          90       100
                  ....*....|....*....|....*....
gi 1098696469 225 ITPLLARKMGDLYVNFNDLTTFTHVKNAL 253
Cdd:cd07041    81 IRPEVAQTLVELGIDLSGIRTAATLQQAL 109
PAS COG2202
PAS domain [Signal transduction mechanisms];
10-129 6.68e-22

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 91.24  E-value: 6.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  10 ELQFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQ 89
Cdd:COG2202     9 SERRLRALVESSPDAIIITDL---DGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAALAGGGVWRGE 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1098696469  90 ILNYTKDNRPFWNELYIDPLWMED--KLYFVGVQKDITEKVK 129
Cdd:COG2202    86 LRNRRKDGSLFWVELSISPVRDEDgeITGFVGIARDITERKR 127
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 34-126 2.82e-18

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 77.50  E-value: 2.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  34 DNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIaaRSSITVQILNYTKDNRPFWNELYIDPLWMED 113
Cdd:pfam13426   1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREG--KAVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....*
gi 1098696469 114 K--LYFVGVQKDITE 126
Cdd:pfam13426  79 GelVGIIAILRDITE 93
SpoIIAA COG1366
Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction ...
 149-231 6.17e-11

Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) [Signal transduction mechanisms];


Pssm-ID: 440977 [Multi-domain]  Cd Length: 93  Bit Score: 57.56  E-value: 6.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 149 VPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEEsKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITGITPL 228
Cdd:COG1366     4 VEVRDGVLVLPLIGELDAARAPELREALLEALET-GARRVVLDLSGVTFIDSSGLGALLSLAKAARLLGGRLVLVGVSPA 82


                  ...
gi 1098696469 229 LAR 231
Cdd:COG1366    83 VAR 85
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 15-126 2.49e-10

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 60.30  E-value: 2.49e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  15 QKALDYTRAGLIITDpsLSDNpIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYT 94
Cdd:TIGR02938   7 RQTVDQAPLAISITD--LKAN-ILYANDAFTRITGYTKEEIIGKNESVLSNHTTPPEVYQALWGSLAEQKPWAGKLLNRR 83

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1098696469  95 KDNRPFWNELYIDPLWME--DKLYFVGVQKDITE 126
Cdd:TIGR02938  84 KDGELYLAELTVAPVLNEagETTHFLGMHRDITE 117
STAS pfam01740
STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is ...
 147-252 2.74e-09

STAS domain; The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function.


Pssm-ID: 426404 [Multi-domain]  Cd Length: 106  Bit Score: 53.39  E-value: 2.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 147 PIVPVKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITGIT 226
Cdd:pfam01740   2 PEAEEIPGILILRLDGPLDFANAESLRERLLRALEEGEIKHVVLDLSAVPFIDSSGLGALEELYKELRRRGVELVLVGPS 81

                          90       100
                  ....*....|....*....|....*.
gi 1098696469 227 PLLARKMgDLYVNFNDLTTFTHVKNA 252
Cdd:pfam01740  82 PEVARTL-EKTGLDDIIKIFPTVAEA 106
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
9-129 2.16e-08

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 54.08  E-value: 2.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469   9 NELQFIQKALDYTRAGLIITDPSLSdnpIIYANKGFLDLTGYDIEEILGTNCRFLQGKqtNPTTVKEMKQAIAARSSITV 88
Cdd:COG3852     4 ESEELLRAILDSLPDAVIVLDADGR---ITYVNPAAERLLGLSAEELLGRPLAELFPE--DSPLRELLERALAEGQPVTE 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1098696469  89 Q-ILNYTKDNRPFWNELYIDPL-WMEDKLYFVGVQKDITEKVK 129
Cdd:COG3852    79 ReVTLRRKDGEERPVDVSVSPLrDAEGEGGVLLVLRDITERKR 121
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 17-129 1.22e-07

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 49.21  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  17 ALDYTRAGLIITDpslSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNY-TK 95
Cdd:TIGR00229   8 IFESSPDAIIVID---LEGNILYVNPAFEEIFGYSAEELIGRNVLELIPEEDREEVRERIERRLEGEPEPVSEERRVrRK 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1098696469  96 DNRPFWNELYIDPL-WMEDKLYFVGVQKDITEKVK 129
Cdd:TIGR00229  85 DGSEIWVEVSVSPIrTNGGELGVVGIVRDITERKE 119
PAS COG2202
PAS domain [Signal transduction mechanisms];
12-129 3.57e-07

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 50.02  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAA-RSSITVQI 90
Cdd:COG2202   137 ERLRLLVENAPDGIFVLDL---DGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGgRESYELEL 213

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1098696469  91 LNYTKDNRPFWNELYIDPLWMEDK-LYFVGVQKDITEKVK 129
Cdd:COG2202   214 RLKDGDGRWVWVEASAVPLRDGGEvIGVLGIVRDITERKR 253
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 12-126 2.01e-06

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 48.23  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTnpttvkeMKQAIAARSSITVQIL 91
Cdd:COG3829    11 EELEAILDSLDDGIIVVDA---DGRITYVNRAAERILGLPREEVIGKNVTELIPNSP-------LLEVLKTGKPVTGVIQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1098696469  92 NYTKDNRPFWNELYidPLWMEDKL-YFVGVQKDITE 126
Cdd:COG3829    81 KTGGKGKTVIVTAI--PIFEDGEViGAVETFRDITE 114
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 24-124 2.13e-05

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 42.62  E-value: 2.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  24 GLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTKDNRPFWNE 103
Cdd:cd00130     4 GVIVLDL---DGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLEVRLRRKDGSVIWVL 80

                          90       100
                  ....*....|....*....|...
gi 1098696469 104 LYIDPL--WMEDKLYFVGVQKDI 124
Cdd:cd00130    81 VSLTPIrdEGGEVIGLLGVVRDI 103
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 12-129 1.23e-04

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 43.04  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAARSSITVQIL 91
Cdd:COG5809   141 EKFRLIFNHSPDGIIVTDL---DGRIIYANPAACKLLGISIEELIGKSILELIHSDDQENVAAFISQLLKDGGIAQGEVR 217

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1098696469  92 NYTKDNRPFWNELYIDPLWMEDKLY-FVGVQKDITEKVK 129
Cdd:COG5809   218 FWTKDGRWRLLEASGAPIKKNGEVDgIVIIFRDITERKK 256
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 12-59 1.79e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.92  E-value: 1.79e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1098696469   12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILGTN 59
Cdd:smart00091   1 ERLRAILESLPDGIFVLDL---DGRILYANPAAEELLGYSPEELIGKS 45
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 37-127 7.59e-04

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 40.49  E-value: 7.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  37 IIYANKGFLDLTGYDIEEILGTNCRFLqgkqTNPTTVKEMKQAI----AARSSITVQILNYTKDNRPFWNELYIDPLWME 112
Cdd:COG5805   179 ILFINESIERLFGAPREELIGKNLLEL----LHPCDKEEFKERIesitEVWQEFIIEREIITKDGRIRYFEAVIVPLIDT 254

                          90
                  ....*....|....*..
gi 1098696469 113 D--KLYFVGVQKDITEK 127
Cdd:COG5805   255 DgsVKGILVILRDITEK 271
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 12-124 9.53e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 38.17  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  12 QFIQKALDYTRAGLIITDpslSDNPIIYANKGFLDLTGYDIEEILGTNCRFLQGKQTNPTTVKEMKQAIAA-RSSITVQI 90
Cdd:pfam00989   1 EDLRAILESLPDGIFVVD---EDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQgEESRGFEV 77

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1098696469  91 LNYTKDNRPFWNEL----YIDPLwmEDKLYFVGVQKDI 124
Cdd:pfam00989  78 SFRVPDGRPRHVEVraspVRDAG--GEILGFLGVLRDI 113
PRK11359 PRK11359
cyclic-di-GMP phosphodiesterase; Provisional
 17-127 1.79e-03

cyclic-di-GMP phosphodiesterase; Provisional


Pssm-ID: 183097 [Multi-domain]  Cd Length: 799  Bit Score: 39.37  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469  17 ALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEEILG-TNCRFLQGKQTNPTTVKEMKQAIAARSSITVQILNYTK 95
Cdd:PRK11359  141 AVDHLDRPVIVLDP---ERRIVQCNRAFTEMFGYCISEASGmQPDTLLNIPEFPADNRIRLQQLLWKTARDQDEFLLLTR 217

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1098696469  96 DNRPFWNELYIDPLW--MEDKLYFVGVQKDITEK 127
Cdd:PRK11359  218 TGEKIWIKASISPVYdvLAHLQNLVMTFSDITEE 251
STAS cd06844
Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of ...
 151-231 2.32e-03

Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; The STAS (Sulphate Transporter and Anti-Sigma factor antagonist) domain is found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors, like anti-anti-sigma factors and "stressosome" components. The sigma factor regulators are involved in protein-protein interaction which is regulated by phosphorylation.


Pssm-ID: 132911 [Multi-domain]  Cd Length: 100  Bit Score: 36.69  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1098696469 151 VKDGVSILPIIGVLNEQRYDMLMEKVSTYIEESKDDYFIVDFSGLLEIDTYTVSCIYNLNRLISLTGTEVMITGITPLLA 230
Cdd:cd06844     5 KVDDYWVVRLEGELDHHSVEQFKEELLHNITNVAGKTIVIDISALEFMDSSGTGVLLERSRLAEAVGGQFVLTGISPAVR 84


                  .
gi 1098696469 231 R 231
Cdd:cd06844    85 I 85
PAS_8 pfam13188
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ...
 12-54 2.77e-03

PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463802 [Multi-domain]  Cd Length: 65  Bit Score: 35.60  E-value: 2.77e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1098696469  12 QFIQKALDYTRAGLIITDPslsDNPIIYANKGFLDLTGYDIEE 54
Cdd:pfam13188   1 ERLRALFESSPDGILVLDE---GGRIIYVNPAALELLGYELLG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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