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Conserved domains on  [gi|1103732722|ref|WP_071690070|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Nioella]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-135 1.81e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722  10 ALRRILLATNQFSRNLAQSVGLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:COG1846    15 LLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1103732722  90 NIVITEKGIRALADAPDPLQQRFVRKFSAMEDWEQAALIAALERVA 135
Cdd:COG1846    95 LVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-135 1.81e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722  10 ALRRILLATNQFSRNLAQSVGLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:COG1846    15 LLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1103732722  90 NIVITEKGIRALADAPDPLQQRFVRKFSAMEDWEQAALIAALERVA 135
Cdd:COG1846    95 LVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-120 1.31e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.40  E-value: 1.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722   30 GLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQTNIVITEKG---IRALADAPD 106
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGrelIEQLLEARS 86

                           90
                   ....*....|....
gi 1103732722  107 PLQQRFVRKFSAME 120
Cdd:smart00347  87 ETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-88 1.58e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 56.44  E-value: 1.58e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1103732722  30 GLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQ 88
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-96 3.26e-05

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 40.70  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722  14 ILLATNQFSRNLAQSVGLTAAQLRVLQIVS----EKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:TIGR01889   6 LYLYIKSLKRYLKKEFNLSLEELLILYYLGklenNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDDERKV 85


                  ....*..
gi 1103732722  90 NIVITEK 96
Cdd:TIGR01889  86 IISINKE 92
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
10-135 1.81e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 97.35  E-value: 1.81e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722  10 ALRRILLATNQFSRNLAQSVGLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:COG1846    15 LLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1103732722  90 NIVITEKGIRALADAPDPLQQRFVRKFSAMEDWEQAALIAALERVA 135
Cdd:COG1846    95 LVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLA 140
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
30-120 1.31e-17

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.40  E-value: 1.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722   30 GLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQTNIVITEKG---IRALADAPD 106
Cdd:smart00347   7 GLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGrelIEQLLEARS 86

                           90
                   ....*....|....
gi 1103732722  107 PLQQRFVRKFSAME 120
Cdd:smart00347  87 ETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-88 1.58e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 56.44  E-value: 1.58e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1103732722  30 GLTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQ 88
Cdd:pfam12802   2 GLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 7.28e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 54.48  E-value: 7.28e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1103732722  31 LTAAQLRVLQIVSEKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 14-96 3.26e-05

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 40.70  E-value: 3.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1103732722  14 ILLATNQFSRNLAQSVGLTAAQLRVLQIVS----EKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQT 89
Cdd:TIGR01889   6 LYLYIKSLKRYLKKEFNLSLEELLILYYLGklenNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSEDDERKV 85


                  ....*..
gi 1103732722  90 NIVITEK 96
Cdd:TIGR01889  86 IISINKE 92
HTH_27 pfam13463
Winged helix DNA-binding domain;
31-97 2.90e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 37.27  E-value: 2.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1103732722  31 LTAAQLRVLQIVS-EKGQCTATAISQQMRISQATVTSLVDKLVRQEMVVRERSQTDRRQTNIVITEKG 97
Cdd:pfam13463   1 LTRLEALILHNIGhRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG3432 COG3432
Predicted transcriptional regulator [Transcription];
36-101 2.34e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442658 [Multi-domain]  Cd Length: 83  Bit Score: 35.23  E-value: 2.34e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1103732722  36 LRVLQIVSEKGqCTATAISQQMRISQATVTSLVDKLVRQEMVVRErsqTDRRQTNIVITEKGIRAL 101
Cdd:COG3432    11 ADILEALKNEG-AKKTRIMYKANLSYDRLKKYLDLLEEKGLIEKE---DDGGRRIYRITEKGREFL 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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