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Conserved domains on  [gi|1104406783|ref|WP_071732366|]
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MULTISPECIES: NADP-dependent phosphogluconate dehydrogenase [Bacillus cereus group]

Protein Classification

NADP(+)-dependent, decarboxylating phosphogluconate dehydrogenase( domain architecture ID 11417508)

NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate, as part of the oxidative branch of the pentose phosphate pathway

CATH:  3.40.50.720|1.20.5.320
EC:  1.1.1.44
Gene Ontology:  GO:0004616|GO:0050661|GO:0006098|GO:0046177
PubMed:  35234135|34709178|26479318
SCOP:  3000048

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 16-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


:

Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 926.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEEN-RGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:COG0362    15 RNLALNIADHGFSVAVYNRTAEKTDAFLAEHgKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLLEPG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGP 174
Cdd:COG0362    95 DIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKVDGEPCVTYIGP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 175 NGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVIL 254
Cdd:COG0362   175 DGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRKKDPETGKPLVDVIL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTLLGvEKAELIEAVRQALYMSKICS 334
Cdd:COG0362   255 DKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEG-DKEAFIEDLRDALYASKIVS 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 335 YAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAV 414
Cdd:COG0362   334 YAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKKAQPAWRRVVATAA 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1104406783 415 QQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:COG0362   414 LAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 16-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 926.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEEN-RGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:COG0362    15 RNLALNIADHGFSVAVYNRTAEKTDAFLAEHgKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLLEPG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGP 174
Cdd:COG0362    95 DIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKVDGEPCVTYIGP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 175 NGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVIL 254
Cdd:COG0362   175 DGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRKKDPETGKPLVDVIL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTLLGvEKAELIEAVRQALYMSKICS 334
Cdd:COG0362   255 DKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEG-DKEAFIEDLRDALYASKIVS 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 335 YAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAV 414
Cdd:COG0362   334 YAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKKAQPAWRRVVATAA 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1104406783 415 QQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:COG0362   414 LAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
16-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 901.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEE-NRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:PRK09287    3 KNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLEKG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNN-EPCCSYIG 173
Cdd:PRK09287   83 DIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDgEPCVTYIG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 174 PNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVI 253
Cdd:PRK09287  163 PDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKPLVDVI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 254 LDTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTllGVEKAELIEAVRQALYMSKIC 333
Cdd:PRK09287  243 LDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKF--EGDKAEFIEDVRQALYASKIV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 334 SYAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMA 413
Cdd:PRK09287  321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1104406783 414 VQQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:PRK09287  401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEW 455
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 16-468 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 772.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEII-EENRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:TIGR00873  12 QNLALNMEDHGFTVSVYNRTPSKTDEFLaEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAVIDSLLPLLEKG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGP 174
Cdd:TIGR00873  92 DIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKVDGEPCCTWVGP 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 175 NGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEEtGKPLVDVIL 254
Cdd:TIGR00873 172 GGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKDED-GNPLVDKIL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKdKTLLGVEKAELIEAVRQALYMSKICS 334
Cdd:TIGR00873 251 DTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPE-APKKGVDKEEFIEDVRQALYASKIIS 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 335 YAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAV 414
Cdd:TIGR00873 330 YAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQSGWRKVVALAI 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104406783 415 QQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGT--FHTKW 468
Cdd:TIGR00873 410 TYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGefFHTNW 465
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 586.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 178 GHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 258 GQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKtLLGVEKAELIEAVRQALYMSKICSYAQ 337
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPA-LFEGDKEAFIEDLRQALYASKIISYAQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 338 GFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAVQQG 417
Cdd:pfam00393 160 GFALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAG 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1104406783 418 IPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:pfam00393 240 IPVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
 
Name Accession Description Interval E-value
Gnd COG0362
6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate ...
 16-468 0e+00

6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; 6-phosphogluconate dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440131 [Multi-domain]  Cd Length: 467  Bit Score: 926.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEEN-RGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:COG0362    15 RNLALNIADHGFSVAVYNRTAEKTDAFLAEHgKGKNIVGTYSLEEFVASLERPRKILLMVKAGKPVDAVIEQLLPLLEPG 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGP 174
Cdd:COG0362    95 DIIIDGGNSHFTDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGSKEAYELVKPILEAIAAKVDGEPCVTYIGP 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 175 NGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVIL 254
Cdd:COG0362   175 DGAGHFVKMVHNGIEYADMQLIAEAYDLLRDGLGLSNDEIAEVFAEWNKGELDSYLIEITADILRKKDPETGKPLVDVIL 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTLLGvEKAELIEAVRQALYMSKICS 334
Cdd:COG0362   255 DKAGQKGTGKWTSQSALDLGVPLPLITEAVFARYLSALKEERVAASKLLPGPEAAPFEG-DKEAFIEDLRDALYASKIVS 333

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 335 YAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAV 414
Cdd:COG0362   334 YAQGFALLRAASKEYGWNLDLGEIARIWRGGCIIRARFLDDITEAYDKNPDLPNLLLDPYFADALKKAQPAWRRVVATAA 413

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1104406783 415 QQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:COG0362   414 LAGIPVPAFSSALAYYDSYRSARLPANLIQAQRDYFGAHTYERVDKEGFFHTEW 467
PRK09287 PRK09287
NADP-dependent phosphogluconate dehydrogenase;
16-468 0e+00

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236453 [Multi-domain]  Cd Length: 459  Bit Score: 901.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEE-NRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:PRK09287    3 KNLALNIASHGYTVAVYNRTPEKTDEFLAEeGKGKKIVPAYTLEEFVASLEKPRKILLMVKAGAPVDAVIEQLLPLLEKG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNN-EPCCSYIG 173
Cdd:PRK09287   83 DIIIDGGNSNYKDTIRREKELAEKGIHFIGMGVSGGEEGALHGPSIMPGGQKEAYELVAPILEKIAAKVEDgEPCVTYIG 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 174 PNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVI 253
Cdd:PRK09287  163 PDGAGHYVKMVHNGIEYGDMQLIAEAYDLLKDGLGLSAEEIADVFAEWNKGELNSYLIEITADILRQKDEETGKPLVDVI 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 254 LDTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTllGVEKAELIEAVRQALYMSKIC 333
Cdd:PRK09287  243 LDKAGQKGTGKWTSQSALDLGVPLTLITEAVFARYLSSLKDQRVAASKVLSGPAAKF--EGDKAEFIEDVRQALYASKIV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 334 SYAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMA 413
Cdd:PRK09287  321 SYAQGFALLRAASEEYGWDLDLGEIARIWRGGCIIRAQFLQKITDAYEANPDLANLLLDPYFKDILEEYQDALRRVVALA 400

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1104406783 414 VQQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:PRK09287  401 VQAGIPVPAFSSALSYYDSYRTARLPANLIQAQRDYFGAHTYERTDKEGFFHTEW 455
gnd TIGR00873
6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the ...
 16-468 0e+00

6-phosphogluconate dehydrogenase (decarboxylating); This model does not specify whether the cofactor is NADP only (EC 1.1.1.44), NAD only, or both. The model does not assign an EC number for that reason. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273314 [Multi-domain]  Cd Length: 467  Bit Score: 772.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEII-EENRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKG 94
Cdd:TIGR00873  12 QNLALNMEDHGFTVSVYNRTPSKTDEFLaEEAKGKSIIGAYSIEDFVQSLERPRKIMLMVKAGAPVDAVIDSLLPLLEKG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  95 DILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIGP 174
Cdd:TIGR00873  92 DIIIDGGNSHYPDTERRYKELKAKGILFVGSGVSGGEEGARKGPSIMPGGSPEAWPLVAPIFQSIAAKVDGEPCCTWVGP 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 175 NGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEEtGKPLVDVIL 254
Cdd:TIGR00873 172 GGAGHYVKMVHNGIEYGDMQLICEAYDILKRGLGLSNEEIAEIFTEWNNGELDSYLIEITADILAKKDED-GNPLVDKIL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKdKTLLGVEKAELIEAVRQALYMSKICS 334
Cdd:TIGR00873 251 DTAGQKGTGKWTAINALDLGVPLTLITESVFARYLSSLKEERVAASKVLPGPE-APKKGVDKEEFIEDVRQALYASKIIS 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 335 YAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAV 414
Cdd:TIGR00873 330 YAQGFMLLREASEEYGWDLNLGEIALIWRGGCIIRSVFLDKITKAFAENPDLENLLLAPYFKQALTDAQSGWRKVVALAI 409

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104406783 415 QQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGT--FHTKW 468
Cdd:TIGR00873 410 TYGIPVPAFSAALSFYDGYRTARLPANLLQAQRDYFGAHTYERTDKPRGefFHTNW 465
PTZ00142 PTZ00142
6-phosphogluconate dehydrogenase; Provisional
 16-468 0e+00

6-phosphogluconate dehydrogenase; Provisional


Pssm-ID: 240287 [Multi-domain]  Cd Length: 470  Bit Score: 646.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIE--ENRGKNLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDK 93
Cdd:PTZ00142   14 QNLALNIASRGFKISVYNRTYEKTEEFVKkaKEGNTRVKGYHTLEELVNSLKKPRKVILLIKAGEAVDETIDNLLPLLEK 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  94 GDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYIG 173
Cdd:PTZ00142   94 GDIIIDGGNEWYLNTERRIKRCEEKGILYLGMGVSGGEEGARYGPSLMPGGNKEAYDHVKDILEKCSAKVGDSPCVTYVG 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 174 PNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVI 253
Cdd:PTZ00142  174 PGSSGHYVKMVHNGIEYGDMQLISESYKLMKHILGMSNEELSEVFNKWNEGILNSYLIEITAKILAKKDDLGEEHLVDKI 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 254 LDTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPK--DKTlLGVEKAELIEAVRQALYMSK 331
Cdd:PTZ00142  254 LDIAGSKGTGKWTVQEALERGIPVPTMAASVDARNISALKEERTKASSHLAGPNpaNKT-ETEDKKYFIDDLKNALYCSK 332

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 332 ICSYAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIIS 411
Cdd:PTZ00142  333 IISYTQGFFLIKEASKEFGWNLNLGEIARIWRGGCIIRAVFLDRIKNAFKKNPQLDLLFLDPDFNDELKNKQPSWRKVVS 412

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104406783 412 MAVQQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:PTZ00142  413 MATKNGIPTPAFSASLAYYQMYRSQNLPANLVQAQRDYFGAHTYKRLDRPGAFHTNW 469
PLN02350 PLN02350
phosphogluconate dehydrogenase (decarboxylating)
 18-468 0e+00

phosphogluconate dehydrogenase (decarboxylating)


Pssm-ID: 215200 [Multi-domain]  Cd Length: 493  Bit Score: 626.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  18 LALNFESKGYSVALYDISKEKVDEIIEenRGKN-----LVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLD 92
Cdd:PLN02350   21 LALNIAEKGFPISVYNRTTSKVDETVE--RAKKegnlpLYGFKDPEDFVLSIQKPRSVIILVKAGAPVDQTIKALSEYME 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  93 KGDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNEPCCSYI 172
Cdd:PLN02350   99 PGDCIIDGGNEWYENTERRIKEAAEKGLLYLGMGVSGGEEGARNGPSLMPGGSFEAYKNIEDILEKVAAQVDDGPCVTYI 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 173 GPNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDV 252
Cdd:PLN02350  179 GPGGAGNFVKMVHNGIEYGDMQLISEAYDVLKSVGGLSNEELAEVFAEWNKGELESFLIEITADIFSVKDDKGDGYLVDK 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 253 ILDTAGQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKTLL----GVEKAELIEAVRQALY 328
Cdd:PLN02350  259 ILDKTGMKGTGKWTVQQAAELSVAAPTIAASLDARYLSGLKEERVAAAKVFKEAGLEDILsadsGVDKKQLIDDVRQALY 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 329 MSKICSYAQGFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYF-KEIVESyQGGLR 407
Cdd:PLN02350  339 ASKICSYAQGMNLIRAKSVEKGWNLNLGELARIWKGGCIIRAVFLDRIKKAYDRNPDLASLLVDPEFaKEMVER-QAAWR 417

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104406783 408 QIISMAVQQGIPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:PLN02350  418 RVVSLAINAGISTPGMSASLAYFDTYRRARLPANLVQAQRDYFGAHTYERVDRPGSFHTEW 478
6PGD pfam00393
6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal ...
 178-468 0e+00

6-phosphogluconate dehydrogenase, C-terminal domain; This family represents the C-terminal all-alpha domain of 6-phosphogluconate dehydrogenase. The domain contains two structural repeats of 5 helices each.


Pssm-ID: 459797  Cd Length: 290  Bit Score: 586.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 178 GHYVKMVHNGIEYGDMQLICEAYFFLKQTLDLTAEEFHEIFAEWNKGELNSYLIEITADIFKKKDEETGKPLVDVILDTA 257
Cdd:pfam00393   1 GHYVKMVHNGIEYGDMQLIAEAYDLLKRGLGLSNDEIADVFEEWNKGELDSYLIEITADILRKKDPEDGKPLVDKILDKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 258 GQKGTGKWTSQSALDLGISLPIITESVFARCISALKEERVNASKVLSGPKDKtLLGVEKAELIEAVRQALYMSKICSYAQ 337
Cdd:pfam00393  81 GQKGTGKWTVQEALDLGVPAPTIAEAVFARCLSALKDERVAASKVLPGPPPA-LFEGDKEAFIEDLRQALYASKIISYAQ 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 338 GFTQLKAASEEYDWNLDFGSISMLWRGGCIIRAAFLQNIKEAYETNTDLPNLLLDPYFKEIVESYQGGLRQIISMAVQQG 417
Cdd:pfam00393 160 GFALLRAASKEYGWNLNLGEIARIWRGGCIIRADFLDKIKEAYKKNPDLSNLLLDPYFAKELKEAQPSWRRVVALAVEAG 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1104406783 418 IPIPAFSAAISYYDSYRTAKLPANLLQAQRDYFGAHTYKRVDKEGTFHTKW 468
Cdd:pfam00393 240 IPVPALSAALSYYDGYRSERLPANLIQAQRDYFGAHTYERIDKEGFFHTEW 290
YqeC COG1023
6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];
18-287 3.42e-84

6-phosphogluconate dehydrogenase (decarboxylating) [Carbohydrate transport and metabolism];


Pssm-ID: 440646 [Multi-domain]  Cd Length: 300  Bit Score: 261.18  E-value: 3.42e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  18 LALNFESKGYSVALYDISKEKVDEIIEENrgknLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKGDIL 97
Cdd:COG1023    15 MARRLLRHGHEVVGYDRNPEAVAALAAEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDQVIEELAPLLEPGDIV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  98 IDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISakVNNEPCCSYIGPNGA 177
Cdd:COG1023    91 IDGGNSNYKDDIRRAEELAEKGIHFVDVGTSGGVWGLENGYCLMIGGDKEAVERLEPIFKALA--PGAENGYLHCGPVGA 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 178 GHYVKMVHNGIEYGDMQLICEAYFFLKQ---TLDLtaeefHEIFAEWNKGE-LNSYLIEITADIFKKKDEETG-KPLVDv 252
Cdd:COG1023   169 GHFVKMVHNGIEYGMMQAYAEGFELLEAsefDLDL-----AEVAEVWRRGSvIRSWLLDLTADALAEDPKLEGiSGYVE- 242

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1104406783 253 ilDTagqkGTGKWTSQSALDLGISLPIITESVFAR 287
Cdd:COG1023   243 --DS----GEGRWTVEEAIELGVPAPVITAALFAR 271
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
18-287 1.99e-81

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 253.90  E-value: 1.99e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  18 LALNFESKGYSVALYDISKEKVDEIIEENrgknLVGTHIVEEFVNSLESPRKILLMVNAGEITDKAIDSLVPHLDKGDIL 97
Cdd:PRK09599   15 MARRLLRGGHEVVGYDRNPEAVEALAEEG----ATGADSLEELVAKLPAPRVVWLMVPAGEITDATIDELAPLLSPGDIV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  98 IDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKVNNepccSYI--GPN 175
Cdd:PRK09599   91 IDGGNSYYKDDIRRAELLAEKGIHFVDVGTSGGVWGLERGYCLMIGGDKEAVERLEPIFKALAPRAED----GYLhaGPV 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 176 GAGHYVKMVHNGIEYGDMQLICEAYFFLKQT---LDLtaeefHEIFAEWNKGE-LNSYLIEITADIFkKKDEETGKpLVD 251
Cdd:PRK09599  167 GAGHFVKMVHNGIEYGMMQAYAEGFELLEASrfdLDL-----AAVAEVWRRGSvIRSWLLDLTADAL-AEDPKLDE-ISG 239

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1104406783 252 VILDTagqkGTGKWTSQSALDLGISLPIITESVFAR 287
Cdd:PRK09599  240 YVEDS----GEGRWTVEEAIDLAVPAPVIAAALFMR 271
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 16-173 1.29e-52

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 174.58  E-value: 1.29e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  16 KSLALNFESKGYSVALYDISKEKVDEIIEENrgknLVGTHIVEEFVNSLespRKILLMVNAGEITDKAIDS--LVPHLDK 93
Cdd:pfam03446  12 SPMALNLLKAGYTVTVYNRTPEKVEELVAAG----AIAAASPAEFVAGL---DVVITMVPAGAAVDAVIFGegLLPGLKP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  94 GDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGP-SIMPGGQKDAYEKVKDMLENISAkvnnepCCSYI 172
Cdd:pfam03446  85 GDIIIDGSTSSPEDARRRAKELKEKGLHFLDAPVSGGEAGAENGTlSIMVGGDEEAFERVKPILEAMGA------CVTYI 158


                  .
gi 1104406783 173 G 173
Cdd:pfam03446 159 G 159
gnd_rel TIGR00872
6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) ...
 17-304 6.63e-52

6-phosphogluconate dehydrogenase (decarboxylating); This family resembles a larger family (gnd) of bacterial and eukaryotic 6-phosphogluconate dehydrogenases but differs from it by a deep split in a UPGMA similarity clustering tree and the lack of a central region of about 140 residues. Among complete genomes, it is found is found in Bacillus subtilis and Mycobacterium tuberculosis, both of which also contain gnd, and in Aquifex aeolicus. The protein from Methylobacillus flagellatus KT has been characterized as a decarboxylating 6-phosphogluconate dehydrogenase as part of an unusual formaldehyde oxidation cycle. In some sequenced organisms members of this family are the sole 6-phosphogluconate dehydrogenase present and are probably active in the pentose phosphate cycle. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273313 [Multi-domain]  Cd Length: 298  Bit Score: 177.35  E-value: 6.63e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  17 SLALNFESKGYSVALYDISKEKVDEIiEENRGknlVGTHIVEEFVNSLESPRKILLMVNAGeITDKAIDSLVPHLDKGDI 96
Cdd:TIGR00872  14 NIVRRLAKRGHDCVGYDHDQDAVKAM-KEDRT---TGVANLRELSQRLSAPRVVWVMVPHG-IVDAVLEELAPTLEKGDI 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  97 LIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGPSIMPGGQKDAYEKVKDMLENISAKvnnEPCCSYIGPNG 176
Cdd:TIGR00872  89 VIDGGNSYYKDSLRRYKLLKEKGIHLLDCGTSGGVWGRERGYCFMIGGDGEAFARAEPLFADVAPE---EQGYLYCGPCG 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783 177 AGHYVKMVHNGIEYGDMQLICEAYFFLKQT-LDLTAEEFHEIfaeWNKGE-LNSYLIEITADIFKKkdeetgKPLVDVIL 254
Cdd:TIGR00872 166 SGHFVKMVHNGIEYGMMAAIAEGFEILRNSqFDFDIPEVARV---WRRGSvIRSWLLDLTAIAFRE------SPDLAEFS 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1104406783 255 DTAGQKGTGKWTSQSALDLGISLPIITESVFARCISalKEERVNASKVLS 304
Cdd:TIGR00872 237 GRVSDSGEGRWTVIAAIDLGVPAPVIATSLQSRFAS--RDLDDFANKVLA 284
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 12-221 3.95e-22

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 95.95  E-value: 3.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  12 GVMGKSLALNFESKGYSVALYDISKEKVDEIIEEnrgknlvGTHIVeefvnslESPRK-------ILLMVNAGEITDKAI 84
Cdd:COG2084    10 GAMGAPMARNLLKAGHEVTVWNRTPAKAEALVAA-------GARVA-------ASPAEaaaaadvVITMLPDDAAVEEVL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  85 ---DSLVPHLDKGDILIDGGnTYFVDTIRR-NKRLAEEGINFIGAGVSGGEEGALKGP-SIMPGGQKDAYEKVKDMLENI 159
Cdd:COG2084    76 lgeDGLLAALRPGAVVVDMS-TISPETARElAAAAAARGVRYLDAPVSGGPAGAEAGTlTIMVGGDEAAFERARPVLEAM 154

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104406783 160 SAKVnnepccSYIGPNGAGHYVKMVHNGIEYGDMQLICEAYFFLKQtLDLTAEEFHEIFAEW 221
Cdd:COG2084   155 GKRI------VHVGDAGAGQAAKLANNLLLAGTMAALAEALALAEK-AGLDPETLLEVLSGG 209
garR PRK11559
tartronate semialdehyde reductase; Provisional
 12-183 1.32e-12

tartronate semialdehyde reductase; Provisional


Pssm-ID: 183197 [Multi-domain]  Cd Length: 296  Bit Score: 68.15  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  12 GVMGKSLALNFESKGYSVALYDISKEKVDEIIEENRGKNLVGTHIVEefvnslESPRKILLMVNAGEITDKAI--DSLVP 89
Cdd:PRK11559   11 GIMGKPMSKNLLKAGYSLVVYDRNPEAVAEVIAAGAETASTAKAVAE------QCDVIITMLPNSPHVKEVALgeNGIIE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  90 HLDKGDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGP-SIMPGGQKDAYEKVKDMLENISAKVnnepc 168
Cdd:PRK11559   85 GAKPGTVVIDMSSIAPLASREIAAALKAKGIEMLDAPVSGGEPKAIDGTlSVMVGGDKAIFDKYYDLMKAMAGSV----- 159

                         170
                  ....*....|....*
gi 1104406783 169 cSYIGPNGAGHYVKM 183
Cdd:PRK11559  160 -VHTGDIGAGNVTKL 173
PRK15059 PRK15059
2-hydroxy-3-oxopropionate reductase;
11-202 2.99e-05

2-hydroxy-3-oxopropionate reductase;


Pssm-ID: 185019 [Multi-domain]  Cd Length: 292  Bit Score: 45.78  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  11 VGVMGKSLALNFESKGYSVALYDISKeKVDEIIEenrgknlVGTHIVEEFVNSLESPRKILLMVNAGEITDKAI---DSL 87
Cdd:PRK15059    8 LGIMGTPMAINLARAGHQLHVTTIGP-VADELLS-------LGAVSVETARQVTEASDIIFIMVPDTPQVEEVLfgeNGC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104406783  88 VPHLDKGDILIDGGNTYFVDTIRRNKRLAEEGINFIGAGVSGGEEGALKGP-SIMPGGQKDAYEKVKDMLENISAKVnne 166
Cdd:PRK15059   80 TKASLKGKTIVDMSSISPIETKRFARQVNELGGDYLDAPVSGGEIGAREGTlSIMVGGDEAVFERVKPLFELLGKNI--- 156

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1104406783 167 pccSYIGPNGAGHYVKMVHNGIEYGDMQLICEAYFF 202
Cdd:PRK15059  157 ---TLVGGNGDGQTCKVANQIIVALNIEAVSEALLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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