|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-407 |
7.97e-97 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 294.52 E-value: 7.97e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 15 VWIRFIGETLNGIAMMMLMPFFALYLKDKV-DSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLML 93
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLgLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 94 GFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIAS 173
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 174 STMLFYALLVLLLIQETMPKRTdkeEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNemkRIFGT 253
Cdd:cd17329 161 VLFLLAALVLLFLLPETRPKRR---AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVE---ILGLG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 254 NNPYPYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWFGefntnatiilitLLFVYAIYTLG 333
Cdd:cd17329 235 ESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAV------------LILAMIVLTLG 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104416264 334 EMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSLD 407
Cdd:cd17329 303 EMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-406 |
7.60e-42 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 151.57 E-value: 7.60e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 27 IAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAI 106
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 107 LSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALLVLL 185
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 186 LIQETmPKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKRIFGTNNpypYLMALNG 265
Cdd:cd17325 170 LLPEP-RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIG---LLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 266 LLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWfgefntnatiilITLLFVYAIYTLGEMIMSPVQMTFV 345
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF------------WLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104416264 346 ANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSL 406
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-363 |
4.23e-32 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 124.70 E-value: 4.23e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLM 92
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 93 LGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFII 171
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAdLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 172 ASSTMLFYALLVLLLIQETMPKRTDKEEHKEKEsgavwkiVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKRIF 251
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRE-------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 252 GTnnpYPYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKwfgefntnatiiLITLLFVYAIYT 331
Cdd:COG2814 243 SA---AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS------------LWLLLLALFLLG 307
|
330 340 350
....*....|....*....|....*....|..
gi 1104416264 332 LGEMIMSPVQMTFVANLAPEHLRGTYMGAASL 363
Cdd:COG2814 308 FGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-373 |
4.11e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 121.76 E-value: 4.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLF 97
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 98 IEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTM 176
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAsLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 177 LFYALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMIyLLAGIIISMGFSQTEGMLPLHFDnemkrIFGTNNP 256
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLPLYQE-----VLGLSAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 257 Y-PYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPkwfgefntnATIILITLLFVYAIYTLGEM 335
Cdd:pfam07690 236 LaGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS---------LTLSSLWLLLALLLLGFGFG 306
|
330 340 350
....*....|....*....|....*....|....*...
gi 1104416264 336 IMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGP 373
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-404 |
1.85e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 117.91 E-value: 1.85e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFI 98
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 99 EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLS----KNLVFIIASS 174
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfgwRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 175 TMLFYALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFdneMKRIFGTN 254
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL---LDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 255 NPYPYLMALNGLLVVLFQFqISKWATDKPVGKTMLYGACLFGIGLFFIGWLpkwfgefntnATIILITLLFVYAIYTLGE 334
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSL-LLGLLSDRLIGRKPLLLIGLLLMALGLALLL----------LAPSLLLLLLLLLLLGFGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104416264 335 MIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLG-HFLFTILAVGCVVAGIVYV 404
Cdd:cd06174 308 GGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGlTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-406 |
3.20e-29 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 117.33 E-value: 3.20e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFI 98
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 99 -----EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIA 172
Cdd:cd06173 85 allgsLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVaLLGPGGAFAIN 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 173 SSTMLFYALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKrifG 252
Cdd:cd06173 165 ALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG---G 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 253 TNNPYPYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWFGefntnatiilitLLFVYAIYTL 332
Cdd:cd06173 242 GAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWL------------LLAALFLLGL 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104416264 333 GEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSL 406
Cdd:cd06173 310 AGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-408 |
3.74e-28 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 114.23 E-value: 3.74e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 24 LNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIP 103
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 104 YAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFyALL 182
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYqHLGFAVLFIVAAVLALL-ALL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 183 VLLLIQETMPKRtdkeeHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEmkrifGTNNPYPYLMa 262
Cdd:cd17489 166 LVFLVKDPPPVA-----AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAER-----GISNAGLFFT- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 263 LNGLLVVLFQFQISKWAtDKPVGKTMLY-GACLFGIGLFFIGwlpkwfgeFNTNATIILITLlfvyAIYTLGEMIMSPVQ 341
Cdd:cd17489 235 VYAIALLLSRPFSGKLS-DRKGPKTVIIpGLLLLALGLLLLS--------FAGSPWMLLLAA----VLYGLGFGLLFPAL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104416264 342 MTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDrLLGHFLFTILAVGCVVAGIVYVSLDR 408
Cdd:cd17489 302 QALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE-LFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-180 |
2.89e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 2.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 2 KNTWRELREMDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPI 80
Cdd:cd17325 188 LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPL 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 81 MIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASV 160
Cdd:cd17325 268 ILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL 347
|
170 180
....*....|....*....|.
gi 1104416264 161 V-VLSKNLVFIIASSTMLFYA 180
Cdd:cd17325 348 YdAFGFATPFLAAAALLLLAA 368
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
37-402 |
7.08e-22 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 96.49 E-value: 7.08e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 37 ALYLKDKVDSLLEVGVIMALSPIAASFG---SLIGGRIAD-IYGRKPIMIFSMAsnaLLMLGF--LFIEGFIPYAILS-- 108
Cdd:cd17346 26 ILYLTAQLGDGFSEADAASIYGAYTALVyltPIIGGWLADkVLGARRTVFIGGI---LMALGYllLALSPFSVSMLYLgl 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 109 IFLGLSNSLFHPAASAMVADVTAP--EKRTEAYGLLRMGHNIGAAIGP-IMGASVVVLSKNLVFIIASSTMLFyallvlL 185
Cdd:cd17346 103 ALIIVGNGLFKPNISSLVGKLYDEndPRRDSGFSIFYMGINLGAFLAPlLCGTLGDNYGYHYGFGLAAVGMLL------G 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 186 LIQETMPKRTDKEEhkekesgavwkivMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKR-IFGTNNPYPYLMALN 264
Cdd:cd17346 177 LLIFLLGRKKLLER-------------KKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRlLGGFTIPPSWFQSLN 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 265 GLLVVLFQFQISK-WATDKPVGKT------MLYGACLFGIGLFFIGWLPKWFGEfntNATIILITLLFVYAIYTLGEMIM 337
Cdd:cd17346 244 PLFIILLAPILAAlWTKLGKRGKDpsiptkFALGLLLLGLSFLLMVLAASFAGG---SGKVSALWLVLSYFLQTLGELCL 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104416264 338 SPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHF-------LFTILAVGCVVAGIV 402
Cdd:cd17346 321 SPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDPLAsalvytdYFGLIGVIALVAGII 392
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
29-402 |
8.48e-21 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 92.64 E-value: 8.48e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 29 MMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLgFLFIEGFIPYAILS 108
Cdd:cd17330 15 VFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYV-LLGLSRNLWLLFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 109 IFL-GLSNSLFhPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIASSTMLFYALLvllli 187
Cdd:cd17330 94 RFLdGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLV----- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 188 qetmpkrtdkeehkekesgAVWKIVmrdKALMIYLLAGIIISMGFSQTEGMLPLHfdneMKRIFGTNNPY-PYLMALNGL 266
Cdd:cd17330 168 -------------------LVLFFL---PPLRRLLLVYFLIALAFAGLESVFSLF----LKDRFGFSPSQiGLLLALVGI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 267 LVVLFQFQISKWATDK-PVGKTMLYGACLFGIGLFFIGWLPKwfgefntnatiiLITLLFVYAIYTLGEMIMSPVQMTFV 345
Cdd:cd17330 222 AGILAQLLLIPRLAKRlGERKLLRLGLLLAIIGLLLLPFASS------------VPLLVLAAAILAFGTGIVFPALSALL 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1104416264 346 ANLAPEHLRGTYMG-AASLQWItGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:cd17330 290 SKSVPSKEQGKAQGiIQSLQSL-ARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFL 346
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
46-406 |
1.86e-20 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 92.25 E-value: 1.86e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 46 SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAM 125
Cdd:cd17474 32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 126 VADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVF--IIASSTMLFYALLVllliqeTMPKRTDKEEHKEK 203
Cdd:cd17474 112 IGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFflLAALIPVAFLAILF------LLPEPKEKAKSSSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 204 ESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKRIFGTNNpypYLMALNGLLVVLFQFQISKWATDK- 282
Cdd:cd17474 186 TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIG---LLFAGWSVLLALGSLFVGRLLKKRf 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 283 PVGKTMLYGACLFGIGLFFIGWLPkwfgefntNATIILITLlfvyAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGA-A 361
Cdd:cd17474 263 GARRILVIGLLLYALSLLLLGFVP--------SLALLLIAI----VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLyN 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1104416264 362 SLQWItGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSL 406
Cdd:cd17474 331 FVRFL-GQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-420 |
4.41e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 91.89 E-value: 4.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYG-----RKPIMIFSMA 86
Cdd:COG2211 10 KEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGlSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 87 SNALLMLGFLFIEGFIP------YAILSIFLGLSNSLFHPAASAMVADVTA-PEKRTEAYGLLRMGHNIGAAIGPIMGAS 159
Cdd:COG2211 90 PLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 160 VV-VLSKN------LVFIIASSTMLFYALLVLLLIQETMPKRTDKEEHKEkesgaVWKIVMRDKALMIYLLAGIIISMGF 232
Cdd:COG2211 170 LVaAFGGDaalgyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKE-----SLKALLKNRPFLLLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 233 SQTEGMLPLHFDNEMKRIFGTnnpYPYLMALNGLLVVLFQFqISKWATDKpVGKTMLYGACLFGIGLFFIGWLpkWFGEF 312
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAAL---VGLLLALYFLAALLGAP-LWPRLAKR-FGKKKAFIIGLLLAALGLLLLF--FLGPG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 313 NtnatiiLITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHL-------RGTYMGAASLQWITGSAFGPLLGGFLLD---- 381
Cdd:COG2211 318 N------LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLAlfgy 391
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1104416264 382 ----------RLLGHFLFTILAVGCVVAGIVYVSLDRLVEQRQKDTLTK 420
Cdd:COG2211 392 vagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
32-404 |
2.39e-19 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 88.75 E-value: 2.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 32 LMPFFALYLKDkvdSLLEVGVIMALSPIAASFGSLIGGRIADIYG-RKPIMIFSMASNALlMLGFLFIEGFIPYAILSIF 110
Cdd:cd17370 21 ILPLFLVVLGA---SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSAL-AKPLLALAGSWQLVLLLRI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 111 LG-LSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKN---LVFIIaSSTMLFYALLVLLL 186
Cdd:cd17370 97 LErLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALLLYLLGGnyrTIFLL-AAIPALLALLILLF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 187 IQETMPKRTDKEEHKEKESGAVWkivmrDKALMIYLLAGIIISMGFSqTEGMLPLHFdnemKRIFGTNNPYPYLMALNGL 266
Cdd:cd17370 176 VVKEYPRPPKLRKKSKKTSLKKL-----PKAFWLYLLAVALFALGNF-SFAFLILRA----QELGLSAALIPLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 267 LVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWFGefntnatiiLITLLFVYAIYT-LGEMIMSpvqmTFV 345
Cdd:cd17370 246 VYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWL---------LLLGFILWGLYMgAQESIER----AAV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1104416264 346 ANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYV 404
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| PRK10054 |
PRK10054 |
efflux MFS transporter YdeE; |
33-399 |
1.25e-17 |
|
efflux MFS transporter YdeE;
Pssm-ID: 182213 Cd Length: 395 Bit Score: 84.02 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 33 MPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASnalLMLGFLFIEGFIPYAILSIFL 111
Cdd:PRK10054 27 LPFMTIYLSRQYSlSVDLIGYAMTIALTIGVVFSLGFGILADKFDKKRYMLLAITA---FASGFIAIPLVNNVTLVVLFF 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 112 GLSN---SLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIASSTMLFYALLVLLLIQ 188
Cdd:PRK10054 104 ALINcaySVFSTVLKAWFADNLSSTSKTKIFSLNYTMLNIGWTVGPPLGTLLVMQSINLPFWLAAICSAFPLVFIQIWVQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 189 ETMPKrtdkeehKEKESGAVW--KIVMRDKALMIYLLAGIIISMGFSQ-----TEGMLPLHFDNEMKRIFGTnnpypyLM 261
Cdd:PRK10054 184 RSEKA-------IATETGSVWspSVLLQDKALLWFTCSGFLASFVSGAfasciSQYVMVVADSDFAEKVVAV------VL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 262 ALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLffIGWLpkwfgeFNTNAtiiLITLLFVYAIYTLGEMIMSPVQ 341
Cdd:PRK10054 251 PVNAAMVVSLQYSVGRRLNAANIRPLMTAGTLCFVIGL--VGFI------FSGNS---LLLWGMSAAVFTVGEIIYAPGE 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1104416264 342 MTFVANLAPEHLRGTYMGAASLQWItGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVA 399
Cdd:PRK10054 320 YMLIDHIAPPGMKASYFSAQSLGWL-GAAINPLVSGVILTTLPPWSLFVILALAIVAA 376
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
19-404 |
1.47e-17 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 83.85 E-value: 1.47e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKD-KVDSLLEV----GVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLML 93
Cdd:cd17391 2 WLGNFFTGIGFSLIAPFLPLYIEQlGVTSGGLVelwsGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 94 GFLFIEGFIPYAILSIFLGLSnSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIA 172
Cdd:cd17391 82 LMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLAdLFGIRNVFFIT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 173 SSTMLFYALLVLLLIQEtmpKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKRIFG 252
Cdd:cd17391 161 GGLLFLAFLLTLFFVKE---DFKPVEKKKMVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASN 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 253 TNNPYPYLMALNGLLVVLFQFQISKWAtDKPVGKTMLYGACLFGIGLFFIgwlpkwfGEFNTNATIILItLLFVYAIYTL 332
Cdd:cd17391 238 LAFISGLVFSATGVSSLLSAPRLGKLG-DRIGHHRILLGALLASALLYIP-------QAFVQTPWQLGI-LRFLLGLATG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104416264 333 GemiMSPVQMTFVANLAPEHLRGTYMG-AASLQWItGSAFGPLLGGFLLDRLLGHFLFTILAvGCVVAGIVYV 404
Cdd:cd17391 309 G---LLPAINSLLAKITPKEVAGRIFGyNQSFQYL-GNVAGPLLGSAIAAHFGYRAVFVVTA-LLVLLNAIWS 376
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-402 |
1.83e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.39 E-value: 1.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLnGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALL 91
Cdd:COG2223 5 RVLLLATLAFFL-AFGVWYLWSVLAPPLAEEFGlSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 92 MLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIG-PIMGASVVVLSKNLVFI 170
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAaFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 171 IASSTMLFYALLVLLLIQETmpkrTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSqtegMLPLHFDNEMKRI 250
Cdd:COG2223 164 ILGILLLVVAVLAWLFLRDP----PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFI----GFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 251 FGTNNPYP-YLMALNGLLVVLFQFqISKWATDK-PVGKTMLYGACLFGIGLFFIGWLPkwfgefnTNATIILITLLFVYA 328
Cdd:COG2223 236 FGLSAATAgLLAALFALLGALGRP-LGGWLSDRiGGRRVLLIVFALMALGLLLLALAL-------GSLWLFLVLFLLLGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104416264 329 IYTLGemimSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLG-HFLFTILAVGCVVAGIV 402
Cdd:COG2223 308 ALGGG----NGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-408 |
4.65e-17 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 81.84 E-value: 4.65e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLmPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLF 97
Cdd:COG2271 16 FLAYFLNYLDRSNL-SVAAPPLQADLGlSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 98 IEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTM 176
Cdd:COG2271 95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLaAFGWRAAFLILGLPG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 177 LFYAllvllliqetmpkrtdkeehkekesgavwkivmrdkALMIYLLAGIIISMGFSQTegMLPLHFDNEMKRIFGTNNP 256
Cdd:COG2271 175 LLLA------------------------------------LLRFWLLALAYFLVYFALY--GFLTWLPTYLVEVRGLSLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 257 YP-YLMALNGLLVVLFQFqISKWATDK---PVGKTMLYGACLFGIGLFFIGWLPkwfgefntnATIILITLLFVYAIYTL 332
Cdd:COG2271 217 QAgLLLSLPFLAGIVGSL-LGGWLSDRlgrRRKLVLAIGLLLAALALLLLALLP---------SPALAIALLFLAGFGLG 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 333 GemiMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSLDR 408
Cdd:COG2271 287 G---AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
42-411 |
8.56e-17 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 82.17 E-value: 8.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 42 DKVDSLLEVGVIMALSPIAasfgSLIGGRIAD-IYGRKPIMIFSMAsnaLLMLGFLFIegFIPYAILSIFLGLS-----N 115
Cdd:COG3104 53 SEADAAAIYGAYTALVYLT----PLLGGWLADrLLGQRRAILLGGI---LMALGHFLL--ALPGGVTLFYLGLAliavgN 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 116 SLFHPAASAMVADVTAPE--KRTEAYGLLRMGHNIGAAIGPI---------------------MGASVVVL--------- 163
Cdd:COG3104 124 GLFKPNISSLVGQLYDPGdpRRDAGFTIFYMGINIGAFLAPLlcgylgekygwhygfgaaaigMLIGLIIFllgrkylgd 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 164 -----------SKNLVFIIA------------------SSTMLFYALLVLLLIQETMPKRTDKEEHKekesgavwkivmR 214
Cdd:COG3104 204 iglepdnplskKERLIAVALgalllvlvlagllsnaniANYLLYVIAIIAYFIFILRSKKLTKEERK------------R 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 215 DKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKR-IFGTNNPYPYLMALNGLLVVLFQFQISK---WATDKPVGKTMLY 290
Cdd:COG3104 272 LLAILILFLFSIVFWALYEQAGTSLNLFADRNVDRsLFGFEIPPSWFQSLNPLFIIILAPVFAAlwtKLGKRGKEPSTPT 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 291 gacLFGIGLFFIG----WLPKWFGEFNTNATIILITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAaslqWI 366
Cdd:COG3104 352 ---KFALGLLLLGlgflVMALAALLAGAGGKVSPLWLVLAYLLLTIGELCLSPVGLSMITKLAPARFAGQMMGL----WF 424
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1104416264 367 TGSAFGPLLGGFL--LDRLLGHF-LFTILAVGCVVAGIVYVSLDRLVE 411
Cdd:COG3104 425 LATALGNLLAGLLagLYAVPGYTaYFLLLGGIALVAGVVLLLLSPKLR 472
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
19-402 |
4.81e-16 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 79.14 E-value: 4.81e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFI 98
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 99 EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSkNLVFIIASSTMLF 178
Cdd:cd17477 82 DSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG-ALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 179 YALLVLLLiqetmpkRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSqteGMLPLhfdnemkriFGTNNPYP 258
Cdd:cd17477 161 ALVPLLLT-------RRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFY---SLLPL---------YGLRLGLS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 259 -----YLMALNGLLVVLFQFQISKWAtDKPVGKTMLYGACLfgIGLFFIGWLPKWFGEFNTNATIILITLLFVYAIYTLG 333
Cdd:cd17477 222 vaqaaLLLAAFVLGGLLLQWPLGWLA-DRFDRRRVLLGCAL--LGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLA 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104416264 334 emimspvqMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:cd17477 299 --------LALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
32-408 |
5.15e-16 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 79.16 E-value: 5.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 32 LMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYG-RKPIMIFSMASNALLMLGFLFIEGFIPYAILSIF 110
Cdd:cd17335 16 LLPFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 111 LGlsNSLFHPAASAM-VADVTAPEKRTEAYGLLRMGHNIGAAIG-PIMGASVVVLSKNLVFIIAssTMLFYALLVLLLIQ 188
Cdd:cd17335 96 LG--AFFSAPVVPLVdSITLQYLGEERERYGKQRLWGSIGFGIAaLLVGILIDRSSTYKNYTIA--FYVFAVLMLLALLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 189 ETMPKRTDKEEHKEKESGAVWKIvMRDKALMIYLLAGIIISMGFSQTEGMLPLHfdneMKRIFGTNNPYPYLMALNGLLV 268
Cdd:cd17335 172 ALKFPFRPKHPEPNENTGGLLAL-LRNPRVLAFLLVAFLMGFGHGLIYSFLFWH----LQDLGGSKTLIGLLWTVGVVSE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 269 VLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWfgefntnATIILITLL--FVYAIytlgemiMSPVQMTFVA 346
Cdd:cd17335 247 IPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENP-------WLVLPIELLhgLTFAL-------VWAAAVSYAS 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104416264 347 NLAPEHLRGTYMGA-ASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSLDR 408
Cdd:cd17335 313 AAAPPGLRATAQGLlQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-403 |
3.22e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.46 E-value: 3.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 50 VGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADV 129
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 130 TAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIASSTMLFYALLVLlliqeTMPKRTDKEEHKEKESGAVW 209
Cdd:cd17473 117 FEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLL-----FLPEPARKSKSAASPGAATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 210 KIVMRDKALMIYLLAgIIISMGFSQTEGMLPLHFDNemkRIFGTNNPYPYLMALNGLLVVLFQFQISKWATDKPVGKTML 289
Cdd:cd17473 192 AALPWKRVLPIYFLA-FLAMLLFYVIPIQLPFLLQE---RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 290 YGACLFGIGLFFIGWLPkwfgefntNATIILITLLFVyaiyTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGS 369
Cdd:cd17473 268 IGFALMALGFLLLALAS--------GLWVVLLGAILA----GLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*
gi 1104416264 370 AFGPLLGGFLLDRLLGH-FLFTILAVGCVVAGIVY 403
Cdd:cd17473 336 FLSPLVLGPLVNLTGGLsGAFLILGVLALVLAIVL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
50-399 |
7.01e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.66 E-value: 7.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 50 VGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADV 129
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 130 TAPEKRTEAYGLLRMGHNIGAAIGPIMGASV-VVLSKNLVFIIASSTMLFYALLVLLLIqetmpKRTDKEEHKEKESGAV 208
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLL-----PSLPPKKPGSLGLLSS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 209 WKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFdneMKRIFGTNNPYPYLMALNGLLVVLFQFQISKWATDKPVGKTM 288
Cdd:cd17324 191 LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFL---TDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 289 LYGACLFGIGLFFIGWLPKWFGefntnatIILITLLFvyaiyTLGEMIMSPVQMTFVANLAPEHlRGTYMGAASLQWITG 368
Cdd:cd17324 268 IALLLLAAALLLLTLLGPSPLL-------LLVGLVLW-----GLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLG 334
|
330 340 350
....*....|....*....|....*....|.
gi 1104416264 369 SAFGPLLGGFLLDRLLGHFLFTILAVGCVVA 399
Cdd:cd17324 335 GALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
63-406 |
2.92e-14 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 73.79 E-value: 2.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 63 FGSLIGGRIADIYGRKPIMIFSMASNAL--LMLGFlfiegfiPYAILSIFLGLSNSLF-H--PAASAMVADVTAPEKRTE 137
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALsyLLLAF-------ASSVPMLFLSRLPSVFmHamQAAQMVVTDLTDPGERAA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 138 AYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIASSTMLFYALLVLLLIQETMPKRTDKEEHKEKESGA----VWKI-- 211
Cdd:cd17331 123 ALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPsvfnLKEIlr 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 212 VMRDKALMIYLLAGIIISMGFSQTEGMLPLHfdneMKRIFG-TNNPYPYLMALNGLLVVLFQFQISKWATdKPVG--KTM 288
Cdd:cd17331 203 LLRLPGVAFLLLVKLLSGLPIGMFQSMFSLV----AMDFFGlTPEENGYLMSYAGVLGMVVQGLLVGPLT-KRFGerSLL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 289 LYGACLFGIGLFFIGWLpkwfgefNTNATIILITLLFVYAIYTLGEMIMSpvQMTfvaNLAPEHLRGTYMG-AASLQWIT 367
Cdd:cd17331 278 KLSVALLAIGYLLLAFV-------TTVWQLLVLLLPLVIGGSVLYTVITS--LLT---KAVPPEDTGTALGlSHALFSLV 345
|
330 340 350
....*....|....*....|....*....|....*....
gi 1104416264 368 GSaFGPLLGGFLLdRLLGHFLFTILAVGCVVAGIVYVSL 406
Cdd:cd17331 346 RT-VSPTIGGALL-QAYGFPSFGLLGAAINGLLTVYLLL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-178 |
2.00e-13 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 71.45 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 2 KNTWRELREM--DRNVWIRFIGETLNGIAMMMLMPFFALYLKDKV-DSLLEVGVIMALSPIAASFGSLIGGRIADIYGRK 78
Cdd:COG2223 192 KASLRDQLEAlrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFgLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 79 PIMIFSMASNALLMLGFLFIEG-FIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMG 157
Cdd:COG2223 272 RVLLIVFALMALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLF 351
|
170 180
....*....|....*....|...
gi 1104416264 158 ASVVVLSKN--LVFIIASSTMLF 178
Cdd:COG2223 352 GALLDATGSytAAFLVFAVLALV 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
32-401 |
3.14e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 70.66 E-value: 3.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 32 LMPFFALYLKDkvdSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFL 111
Cdd:cd17478 18 LLPLLIAKLGL---SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 112 GLSNSLFHPAASAMVADVtAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNL----VFIIASSTMLFYALLVllli 187
Cdd:cd17478 95 GIGSAAFHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLglliLLIIPGLAVALLLLRL---- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 188 qetmpKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQtegmlplhfdnemkriFGTNNPYPYLMALNGLL 267
Cdd:cd17478 170 -----RPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVL----------------SSLTTFLPFYLVQRGYS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 268 VVLFQFQISkwatdkpvgktMLYGAClfGIGLFFIGWLPKWFGE------FNTNATIILITLLFVYAIYTL------GEM 335
Cdd:cd17478 229 LVFAGLLLS-----------LFLFAG--AIGTLIGGPLSDRFGRrrviiaSLLLAAPFLLLFLLTPGIWSYillvlaGFL 295
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104416264 336 IMS--PVQMTFVANLAPEHLR---GTYMGaasLQWITGSAFGPLLgGFLLDRLLGHFLFTILAVGCVVAGI 401
Cdd:cd17478 296 LFAsfPVTVVLAQELLPGNVGlasGLMMG---LSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-178 |
7.23e-13 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 69.49 E-value: 7.23e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 1 MKNTWRELREMDRNVWIRFIGETLNGIAMMMlMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPI 80
Cdd:cd17370 188 KKSKKTSLKKLPKAFWLYLLAVALFALGNFS-FAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 81 MIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP-IMGAS 159
Cdd:cd17370 267 LILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASlIAGYL 346
|
170
....*....|....*....
gi 1104416264 160 VVVLSKNLVFIIASSTMLF 178
Cdd:cd17370 347 WDLISPSAAFLFSAVLALI 365
|
|
| PRK11646 |
PRK11646 |
multidrug efflux MFS transporter MdtH; |
66-381 |
1.06e-12 |
|
multidrug efflux MFS transporter MdtH;
Pssm-ID: 183255 Cd Length: 400 Bit Score: 69.32 E-value: 1.06e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 66 LIGGRIADIYGRKPIMIFSMASNALlmlGFLFI----EGFIpyAILSIFL-GLSNSLFHPAASAMVADVTAPEKRTEAYG 140
Cdd:PRK11646 64 IFGGAIADRFGAKPMIVTGMLMRAA---GFATMaiahEPWL--LWLSCILsGLGGTLFDPPRTALVIKLIRPHQRGRFFS 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 141 LLRMGHNIGAAIGPIMGA-------SVVVLSKNLVFIIASstmLFYALLVLLLIQETMpkRTDKEEHKEKesgavwkiVM 213
Cdd:PRK11646 139 LLMMQDSAGAVIGALLGSwllqydfRLVCATGAVLFVLAA---AFNAWLLPAYKLSTV--RTPVREGMTR--------VL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 214 RDKALMIYLLAGIIISMGFSQTEGMLPLHfdneMKRIFGTNNPYPYLMALNGLLVVLFQFQISKWATDK-PVGKTMLYGA 292
Cdd:PRK11646 206 RDKRFVTYVLTLTGYYMLAVQVMLMLPIM----VNDIAGSPSAVKWMYAIEACLSLTLLYPIARWSEKRfRLEHRLMAGL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 293 CLFGIGLFFIGWLPKwfgefntnatiiLITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFG 372
Cdd:PRK11646 282 LIMSLSMFPIGMVSN------------LQQLFTLICLFYIGSIIAEPARETLSASLADARARGSYMGFSRLGLALGGAIG 349
|
....*....
gi 1104416264 373 PLLGGFLLD 381
Cdd:PRK11646 350 YIGGGWLFD 358
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
28-402 |
1.63e-12 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 68.40 E-value: 1.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 28 AMMMLMPFFALYLKD-KVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMAsnaLLMLGFL--FIEGFIPY 104
Cdd:cd17472 11 GMFLVLPVLSVYAKSlPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLL---LFIAGSLlaAYATSIYG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 105 AILSIFLGLSNSLfHPAASAMVADVTAPEKRTEAYGLlrMGHNIGAAI------GPIMGAsvvVLSKNLVFIIASstmlF 178
Cdd:cd17472 88 LILGRALQGSGAI-SSVVMALLADLTREENRTKAMAL--IGASIGIAFaismvlGPLLAA---HLGVSGLFLITA----I 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 179 YALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMIYlLAGIIISMGFSQTEGMLPLhfdnEMKRIFGTNNP-- 256
Cdd:cd17472 158 LSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLD-FSIFILHFVLMAFFYILPL----LLTQLGGGKGQlw 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 257 --YPYLMALNGLLVVLFQFQISKWATDKPVgktmlygaCLFGIGLFFIGWLPKWFGEFNTNATIILITLLFVyaiytlGE 334
Cdd:cd17472 233 kvYLPAILIGFILMVPFVIYAEKKGKMKQV--------FVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFI------GF 298
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1104416264 335 MIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:cd17472 299 NLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLV 366
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
46-413 |
2.09e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 2.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 46 SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAM 125
Cdd:COG0738 41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 126 VADVTaPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNL----VFIIASSTMLFYALLVLLLIQETMPKRTDKEEHK 201
Cdd:COG0738 121 VAALG-PETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLswhlPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 202 EKESGAVWKIVmrdkalmiYLLAGIIISMGFSQTEGMLPLHFDNEMKRIFGTNNPYP-YLMALNGLLVVLFQFqISKWAT 280
Cdd:COG0738 200 AASLKSLLKNP--------RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAaLGLSLFWGGMTIGRF-LGGFLL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 281 DKPVGKTMLYGACLFGIGLFFIGWLPkwfgefnTNATIILITLLFVYaiytLGEMIMSPVQMTFVANLAPEHlRGTYMGA 360
Cdd:COG0738 271 KRFGPVRLLRLSALLAAVGLLLALLA-------PGPWLALIGLALVG----LGLSLMFPTIFSLALDGLGKR-TAAAVSA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1104416264 361 ASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSLDRLVEQR 413
Cdd:COG0738 339 VLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-190 |
2.69e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 67.59 E-value: 2.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 14 NVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGR--KPIMIFSMASNAL 90
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGlSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 91 LMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP-IMGASVVVLSKNLVF 169
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPlLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|.
gi 1104416264 170 IIASSTMLFYALLVLLLIQET 190
Cdd:COG2271 341 LLLAALALLAALLALLLLRET 361
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
24-401 |
3.55e-12 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 67.19 E-value: 3.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 24 LNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIAD-IYGRKPIMIFSMASNALLMLGFLFIEGF 101
Cdd:cd17471 7 LTGLAGAFVLPYLSLFLTEELGaSPLQIGIFMTLSALSGIVVSQWLGRLSDrGGDRKPLILLALLAGALGYLLFAFLRNY 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 102 IPYAILSI-FLGLSNSLFhPAASAM---VADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTM 176
Cdd:cd17471 87 WVLLLVGVvLLSLGAAAF-PQLFALareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLdVLGFTGLFLLAALLY 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 177 LFYALLVLLLIQETMPKRTDKEEHKEKESGAvwkivmRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKrifGTNNP 256
Cdd:cd17471 166 LVVALLVLFLLPSVKPPAQKATPASSLVKAP------VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELG---GSESW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 257 YPYLMALNGLLVVLFQFQISKWATdKPVGKTMLYGACLFGIGLFFIGWLpkwfgefnTNATIILITLLFVYAIYTlgeMI 336
Cdd:cd17471 237 VGLLFGLAAALEIPIMLLAGLLAK-RFGKRRLLLAGFLAGVLFYLGLAL--------ATSLWQLIALQLLNAIFI---GI 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104416264 337 MSPVQMTFVANLAPEHLrGT----YMGAASLQWITGSafgpLLGGFLLDRLLGHFLFTILAVGCVVAGI 401
Cdd:cd17471 305 TAGLGISYFQDLMPGQP-GLattlYSNASRIGSLLGG----LLAGVIAQYFGYRAVFLVCAVLALLALV 368
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
6-158 |
7.12e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.43 E-value: 7.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 6 RELREMDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSM 85
Cdd:cd17478 188 STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASL 267
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104416264 86 ASNALLMLGFLFIEGfIPYAILSIFLGLSNSLFHPAASAMVADVtAPEKRTEAYGL-LRMGHNIGAAIGPIMGA 158
Cdd:cd17478 268 LLAAPFLLLFLLTPG-IWSYILLVLAGFLLFASFPVTVVLAQEL-LPGNVGLASGLmMGLSFGLGGIGAPVLGA 339
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
32-389 |
9.15e-12 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 66.11 E-value: 9.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 32 LMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYG-RKPIMIFSMASNALLMLGFLFI---EGFIPYAIL 107
Cdd:pfam12832 18 LLPYWGLYLRSIGLNPSEIGLITAILPLTRILAPPIWGWLADRTGkRKAVVRLASILAAVLFLSVLFIpisLTFWWLALL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 108 ----SIFLGLSNSLFHPAAsamvadVTAPEKRTEAYGLLRMGHNIG-AAIGPIMGASVVVLSKNLVFIiasstMLFYALL 182
Cdd:pfam12832 98 vvlfSFFWNAILPQFEVAT------LQHLGEKRKDYGRQRLWGSVGfALSVFGLGALFDHYSVGLLPS-----VLFYLFA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 183 VLLLIQETMP-KRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNemkriFGTNNP-YPYL 260
Cdd:pfam12832 167 ALMLLSLLLPlAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLEN-----LGASNTlLGAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 261 MALNGLLVVLFqFQISKWATDKPVGKTMLygacLFGIGLFFIGWLpkWFGEFNTNATIILITLLFvYAIyTLGemIMSPV 340
Cdd:pfam12832 242 WALGVVAEIPL-FFYAHRLLRRFGHRNLL----IIALLLTALRWL--LYAFFVENPWLVLPIQFL-HAI-SFG--LTHAA 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1104416264 341 QMTFVANLAPEHLRGTYMGA-ASLQWITGSAFGPLLGGFLLDRLLGHFLF 389
Cdd:pfam12832 311 AIEYVRRIFPGSLQGTGQALySGLYFGLGGALGSLIGGQLWDLFGARFTF 360
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
49-409 |
1.01e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.68 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 49 EVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVAD 128
Cdd:cd17365 35 QLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 129 VTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALlvllliqetmpkrtdkeehkekesga 207
Cdd:cd17365 115 YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIpAFGWRSVFLLGGVPPLILLP-------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 208 vwkivmrdkALMIYLLAGIIISMGfsqtegmlplhfdneMKRIFGTNNPYPYLMALNGL-----LVVLFQFQIS------ 276
Cdd:cd17365 169 ---------LLRGTLLLWVTFFMG---------------LLLVYLLNSWLPKLMVEAGYslsqaLTITLLLNIGgvigsl 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 277 --KWATDK-PVGKTMLYGACLFGIGLFFIGwlpkwfgeFNTNATIILITLLFVYAIYTLGEMIMSPvqmTFVANLAPEHL 353
Cdd:cd17365 225 llGWLADRfGPKRVLALFFALGAVSLALLG--------VSPASLVLLYVLVFLAGACVNGAQVGLY---ALAARFYPTEV 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1104416264 354 RGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHF-LFTILAVGCVVAGIVYVSLDRL 409
Cdd:cd17365 294 RATGVGWALGVGRLGAILGPLLGGLLLAAGLGPEsVFLALAIPAALGALAVLLLRLR 350
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
49-380 |
1.40e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.76 E-value: 1.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 49 EVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVAD 128
Cdd:TIGR00895 53 QLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 129 VTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALLVLLLIQEtmPKRTDKEEHKEKESGA 207
Cdd:TIGR00895 133 YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFLPE--SIDFLVSKRPETVRRI 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 208 VWKIVMRDKALMIYLLAGIIISMGfsQTEGMLPLHFDNEMKRI---------------FGTNNPYPYLMA-------LNG 265
Cdd:TIGR00895 211 VNAIAPQMQAEAQSALPEQKSTQG--TKRSVFKALFQGKTARItvllwllyfmllvgvYFLTNWLPKLMVelgfslsLAA 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 266 LLVVLFQFQ------ISKWATDKPVGKTMLYGACLFGIGLFFIGwlpkwFGEFNTNatiILITLLFVYAIYTLGEMIMSP 339
Cdd:TIGR00895 289 TGGALFNFGgvigsiIFGWLADRLGPRVTALLLLLGAVFAVLVG-----STLFSPT---LLLLLGAIAGFFVNGGQSGLY 360
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1104416264 340 VQMtfvANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLL 380
Cdd:TIGR00895 361 ALM---ALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
11-180 |
1.97e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 1.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 11 MDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIAD-IYGRKPIMIFSMASN 88
Cdd:cd06174 201 KNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGlSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLM 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 89 ALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNL- 167
Cdd:cd06174 281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLt 360
|
170
....*....|....
gi 1104416264 168 -VFIIASSTMLFYA 180
Cdd:cd06174 361 gAFLVLAVLLLLAA 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
30-402 |
2.34e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.46 E-value: 2.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 30 MMLMPFFALYLK---DKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAI 106
Cdd:cd17316 15 FFLIGFVAPVLAaefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 107 LSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKN-----LVFIIaSSTMLFYAl 181
Cdd:cd17316 95 LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgwrILFLI-GALPALLA- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 182 lvllliqetmpkrtdkeehkekesgavwkIVMRdKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKRIFGTNNPYPYLM 261
Cdd:cd17316 173 -----------------------------LLLR-RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 262 ALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWfgefntnatiiliTLLFVYAIYTLGEMIMSPVQ 341
Cdd:cd17316 223 SLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT-------------LLLLLLFILSFFVGGVWGAL 289
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104416264 342 MTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:cd17316 290 YAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-154 |
3.73e-10 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 60.89 E-value: 3.73e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLM 92
Cdd:pfam07690 200 DPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104416264 93 LGFLFI---EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP 154
Cdd:pfam07690 280 LGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
62-395 |
3.93e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.05 E-value: 3.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 62 SFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGL 141
Cdd:cd17320 48 ALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 142 LRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALLVLLLIQETMPKrtDKEEHKEKESGAVWKIVMRDKALMI 220
Cdd:cd17320 128 LMMILAIAPALAPLLGGLLLlFFGWRAIFVFLALLGLLLLLLVLLFLPETLPE--EKRKPLLSSLLRAYKRVLKNRRFLG 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 221 YLLAGIIISMGFSQTEGMLPLHFdneMKRIFGTNNPYPYLMALNGLLVVLFQFqISKWATDKPVGKTMLYGAcLFGIGLF 300
Cdd:cd17320 206 YALALGLSFAGLFAYLAAAPFIY---IEQLGLSPAQFGLLFALNAIALILGSL-LNGRLVRRFGPRRLLRLG-LLLLLAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 301 FIGWLPKWFGEFNTNATIILITLLFVYAIYTLGEMIMSPVQMTFvanlapEHLRGTYMGAASLQWITGSAFGPLLGGFLL 380
Cdd:cd17320 281 ALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF------PHVAGTASALLGFLQFLIGALAGALVGLLP 354
|
330
....*....|....*
gi 1104416264 381 DRLLGHFLFTILAVG 395
Cdd:cd17320 355 NGTALPMGLLILVLG 369
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
13-158 |
4.04e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 60.60 E-value: 4.04e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLM 92
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 93 LGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGA 158
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-164 |
5.07e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 5.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 1 MKNTWRELREmDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKV-DSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKP 79
Cdd:COG2211 217 LKESLKALLK-NRPFLLLLLAYLLFFLALALVAALLLYYFKYVLgLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 80 IMIFSMASNALLMLGFLFI--EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPE-----KRTEA--YGLLRMGHNIGA 150
Cdd:COG2211 296 AFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGlyFGIFTFAIKLGQ 375
|
170
....*....|....
gi 1104416264 151 AIGPIMGASVVVLS 164
Cdd:COG2211 376 ALAGALAGLLLALF 389
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
51-375 |
6.13e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 60.34 E-value: 6.13e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 51 GVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNA---LLM-----LGFLFIEgfipyAILSIFLGLSNSLfhpaA 122
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAAldyLLMafaptLWWLYLG-----RIIAGITGATGAV----A 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 123 SAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNLVFIIASSTMLFYALLVLLLIQETMP--KRTDKEEH 200
Cdd:cd17388 112 AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPpeRRRAFRWR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 201 KEKESGAVWKiVMRDKALMIYLLAGIIISMGFSQTEGMLPLHFDNEMK---RIFGtnnpypYLMALNGLLVVLFQFQISK 277
Cdd:cd17388 192 RANPFGSLRW-LTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDwspTMVG------LSLAVFGLLHALFQAFVTG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 278 WATDKpVG--KTMLYGACLFGIGLFFIGWLPKWFGEFntnatIILItllfvyaIYTLGEMIMsPVQMTFVANLAPEHLRG 355
Cdd:cd17388 265 PIAKR-LGekRAILLGLAADALGFLLLAFATQGWMVF-----PILI-------LLALGGIAG-PALQGLLSRQVPENEQG 330
|
330 340
....*....|....*....|.
gi 1104416264 356 TYMGA-ASLQWITgSAFGPLL 375
Cdd:cd17388 331 ELQGVlTSLTSLT-SIIGPLL 350
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
4-154 |
1.01e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 59.94 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 4 TWRELREM--DRNVW-IRFIGETLNGIAMMMLMpFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYG--- 76
Cdd:cd17475 187 LLRSLKEVlrNRDVWlIAIAGALLVAPQFALLT-FLLLFLHDHLGlSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggr 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 77 RKPIMIFSMASNALLMLGFLFIEGFIPY---AILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIG 153
Cdd:cd17475 266 RRPVLVITAAIAAAALLVLSLLSPGTPLwllVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIG 345
|
.
gi 1104416264 154 P 154
Cdd:cd17475 346 P 346
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
31-404 |
1.16e-09 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 59.55 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 31 MLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNAL--LMLGflFIEGFIPYAILS 108
Cdd:cd17390 14 MILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALgyVLLG--FSTSLALLFLSR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 109 IFLGL---SNSLfhpaASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSK--NLVFIIASSTMLFYAllv 183
Cdd:cd17390 92 IPLGIfkhTQSL----CKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGgfYYVALLCSAIFILNA--- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 184 llliqetmpkrtdkeehkekesGAVWKIV--MRDkALMIYLLAGIIISMGFSqtegmlplHFDNEMKRIFGTNNPYP-YL 260
Cdd:cd17390 165 ----------------------GLVWFLLskLWD-LLLVRFLMGFSVLLFRS--------NFSLYLEERFDLSPKTIgYL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 261 MALNGLLVVLFQFQISKWAT--DKPVGKTMLYGACLFGIGLFFIGwlpkwfgeFNTNATIILITLLFVYAIYTLGEMIMS 338
Cdd:cd17390 214 ISYSGVLGALSGFLVGRILKlyKNNEYLLLLHSFILLALSLLGLA--------LAPSIWLLVLCLTPLSISSAVLRTCST 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 339 PVQMTFVANlapeHLRGTYMGAASLQWITGSAFGPLLGGFLLDrlLGHFLFTILAVGCVVAGIVYV 404
Cdd:cd17390 286 SLLLSRGKS----KERGTLLGVGQSVTSLARILAPLLSGLLQE--FSVSGPGLLGAVLALAAILLM 345
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
24-158 |
5.15e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 5.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 24 LNGIAMMMLMPFFALYLKD-KVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIE--- 99
Cdd:cd17321 179 LLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGads 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 100 GFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP-IMGA 158
Cdd:cd17321 259 SVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVaLLGA 318
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
54-383 |
1.12e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 56.86 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 54 MALSPIAasfgsligGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPE 133
Cdd:cd17328 48 MVLSPIF--------GYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKE 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 134 KRTEAYGLLRMGHNIGAAIGPIMGASV--VVLSKNLVFIIASSTMLFYALLVLLLIQEtmPKRTDKEEHKEKES-----G 206
Cdd:cd17328 120 KRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLFVRE--PPRGAAEGGVMAKStatsfL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 207 AVWKIVMRDKALMIYLLAGIIIS---MGFSQTegmlPLHFdneMKRIFGTNNPYPYLMALN--------GLLVVLFQFQI 275
Cdd:cd17328 198 ADLKALAKNPSFILSTLGFTAVSfvtGALAFW----APTF---FLRAFGVGDLSSADVGLIfgaitciaGVLGVLLGGIL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 276 SKWATDKPVGKTMLYGA-CLFGIGLFFIGWLPkwFGEFNTNATIILItllfvYAIYTLGEMIMSPVQMTFVANLAPEHlR 354
Cdd:cd17328 271 ADRLRRKTPRADPLVCAvGLLAAAPFLFLALV--LALSNLLLAWVLL-----FLGEFLLSLNWAPVFAILLYVVIPTR-R 342
|
330 340 350
....*....|....*....|....*....|...
gi 1104416264 355 GTymgAASLQWIT----GSAFGPLLGGFLLDRL 383
Cdd:cd17328 343 ST---ASAIQILLshllGDAGSPYLIGLISDLL 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
15-180 |
9.29e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 53.81 E-value: 9.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 15 VWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEV----GVIMALSPIAASFGSLIGGRIADIYG-RKPIMIFSMASnA 89
Cdd:cd17391 203 LISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLafisGLVFSATGVSSLLSAPRLGKLGDRIGhHRILLGALLAS-A 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 90 LLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASV-VVLSKNLV 168
Cdd:cd17391 282 LLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIaAHFGYRAV 361
|
170
....*....|..
gi 1104416264 169 FIIASSTMLFYA 180
Cdd:cd17391 362 FVVTALLVLLNA 373
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
11-178 |
1.43e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 1.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 11 MDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIAD--IYGRKPIMIFSMASN 88
Cdd:cd17352 181 KDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADkpRIGRLYLYIFTLLIL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 89 ALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKN-- 166
Cdd:cd17352 261 GLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDyd 340
|
170
....*....|..
gi 1104416264 167 LVFIIASSTMLF 178
Cdd:cd17352 341 AAFYFCGACLLL 352
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
42-174 |
1.95e-07 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 52.66 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 42 DKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSN---SLf 118
Cdd:cd17389 58 RRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKgnvSL- 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1104416264 119 hpaASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGA--SVVVLSKNLVFIIASS 174
Cdd:cd17389 137 ---STAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAyfASFTRSLGEVFFSMPA 191
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-408 |
4.05e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 260 LMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKWFgefntnatiiliTLLFVYAIYTLGEMIMSP 339
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW------------LLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1104416264 340 VQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSLDR 408
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
214-402 |
4.68e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 51.51 E-value: 4.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 214 RDKALMIYLLAGIIISMGFSQTEGMLPLhfdneMKRIFGTNNPY-PYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGA 292
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-----IAADLGASPAQaGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 293 CLFGIGLFFIGWLPKWfgefntnatiilITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFG 372
Cdd:COG2814 83 LLFALGSLLCALAPSL------------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|
gi 1104416264 373 PLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLL 180
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
13-198 |
1.14e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 50.30 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKD---KVDSLLEV--GVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMAS 87
Cdd:PRK09874 14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVEQlgvTGHSALNMwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 88 NALLMLGFLFIEGFIPYAILSIFLGLSNSlFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKN 166
Cdd:PRK09874 94 MGIVMVLMGLAQNIWQFLILRALLGLLGG-FVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLAdSYGLR 172
|
170 180 190
....*....|....*....|....*....|..
gi 1104416264 167 LVFIIASSTMLFYALLVLLLIQETMPKRTDKE 198
Cdd:PRK09874 173 PVFFITASVLFLCFLVTLFCIRENFQPVSKKE 204
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
50-402 |
2.37e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 49.55 E-value: 2.37e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 50 VGVIMALSPIAASFGSLIGGRIADI----YG-RKPIMIFSMASNALLMLGFLFIEGF------------IPYAILSI-FL 111
Cdd:cd17313 36 IGFVWTLGPILGLFVQPLVGSLSDRcnsrIGrRRPFILVGAPLAALGLILIPNAADIglalgdgprtwaLVLFVLGIvLL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 112 GLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGA---------SVVVLSKNLVFIIASSTMLFYALL 182
Cdd:cd17313 116 DFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAilwdhnwfgFALGGNLKVPFYIGAIILLVCVLV 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 183 VLLLIQETMPKRTDKEEHKEKESGAVWK-----IVMRDKALMIYLLAGIIISMGFSQTE-------GMLPLHFDNEMKRI 250
Cdd:cd17313 196 TLFFVKEPPLSPEAGEHSENPSLGEVLKsllklLKIMPRSLLRLLLVIFFWWIAFFPFElfftdymGEEVYHGTSAASSH 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 251 FG-TNNPYPYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPkwfgefntnaTIILITLLFvyAI 329
Cdd:cd17313 276 YGaGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVH----------NVTVALVLF--AL 343
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104416264 330 YTLGEMIMSPVQMTFVANLAPEHLR--GTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:cd17313 344 GGIGWATININPYPLVSDYHSESGRgqGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
42-406 |
3.87e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 48.42 E-value: 3.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 42 DKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPA 121
Cdd:cd17312 32 EIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 122 ASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVV-LSKNLVFIIASSTMLFYAllvllliqetmpkrtdkeeh 200
Cdd:cd17312 112 CVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASyYGWRAAFLVPGIVGLVVA-------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 201 kekesgAVWKIVMRDKALMIYLLAGIIISMGFSQT--EGMLPLHFDNEMKRIFGTNNPYPYLMALNGLLVVLfqfqISKW 278
Cdd:cd17312 172 ------IILFFFLRDSPPYVWVLSLAYAFVYIVRYacLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTI----LAGL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 279 ATDKPVGKTMLYGACLFGIGLFFIGWLPKWF-GEFNTNATIILITLLFVYAIYTLGEMIMSpvqmtfvANLAPEHLRGTY 357
Cdd:cd17312 242 LSDKLFGGRRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFFVGGPINLIGGAAA-------QDIGRKEAAGTA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1104416264 358 MGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVSL 406
Cdd:cd17312 315 TGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
63-232 |
3.98e-06 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 48.53 E-value: 3.98e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 63 FGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLL 142
Cdd:TIGR00710 55 AGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSIL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 143 RMGHNIGAAIGPIMGASVVV-LSKNLVFIIASSTMLFYALLVLLLIQETMPKRTDKEEHKekeSGAVWKIVMRDKALMIY 221
Cdd:TIGR00710 135 MPVLALAPAVAPLLGGYILVwLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQIST---YFETFLLLLKSKMFWGY 211
|
170
....*....|.
gi 1104416264 222 LLAGIIISMGF 232
Cdd:TIGR00710 212 ALIYGASFGGF 222
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
16-151 |
4.48e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.45 E-value: 4.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 16 WIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGF 95
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLC 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 96 LFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAA 151
Cdd:cd17371 82 GFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWL 137
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
35-177 |
4.78e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 4.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 35 FFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADI-YGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLG 112
Cdd:cd17474 220 YLPFLLELLYGiSPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFG 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 113 LSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP-IMGASVVVLSKNLVFIIASSTML 177
Cdd:cd17474 300 LGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPlLFGLLLEIFGLSAPFLVGAAIAL 365
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
66-161 |
8.79e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.55 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 66 LIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMG 145
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAV 128
|
90
....*....|....*.
gi 1104416264 146 HNIGAAIGPIMGASVV 161
Cdd:cd17321 129 VGIGAALGPLLGGLLL 144
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-179 |
1.29e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.80 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-----SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMAS 87
Cdd:cd17504 177 RNVLLANITALLAGFGMFMVFQLLPQLLQLPTPtgfglGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVI 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 88 NAL-LMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKN 166
Cdd:cd17504 257 SAVgLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTV 336
|
170
....*....|...
gi 1104416264 167 LVFIIASSTMLFY 179
Cdd:cd17504 337 SITSGGVPTEGAY 349
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
2-178 |
1.40e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 47.07 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 2 KNTWRELREmDRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPI 80
Cdd:COG2270 228 RRTLRELRR-YRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGfSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRV 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 81 MIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSnslFHP--AAS-AMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMG 157
Cdd:COG2270 307 ILVSLVIWIVVCLAAYFLTTALAFWILGLLIGLV---MGGiqALSrSLLARLIPPGREAEFFGLYALSGKAASFLGPLLF 383
|
170 180
....*....|....*....|.
gi 1104416264 158 ASVVVLSKNLVFIIASSTMLF 178
Cdd:COG2270 384 GLVTQLTGSQRLGILSLIVFF 404
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
15-180 |
1.55e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 15 VWIRFIGETLNGIAMMMLMPFFALYLKDK-VDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLML 93
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLQERgGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 94 GFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSKNL--VFII 171
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLsgAFLI 358
|
....*....
gi 1104416264 172 ASSTMLFYA 180
Cdd:cd17473 359 LGVLALVLA 367
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-180 |
2.05e-05 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 46.41 E-value: 2.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYG----RKPIMIFSMAS 87
Cdd:cd17319 179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGfSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLrgarRLVIIIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 88 NALLMLGFLFIEGFIPYAILSIFLGLSNSLFhPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGP-IMGASVVVL-SK 165
Cdd:cd17319 259 AVGLLLAYLTTSPVVAVILLSLAGFGIGAAS-PVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPlLIGYLVDATgSY 337
|
170
....*....|....*
gi 1104416264 166 NLVFIIASSTMLFYA 180
Cdd:cd17319 338 TAAFLFLAAVALLAA 352
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
59-158 |
2.35e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 46.03 E-value: 2.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 59 IAASFGSLIGGRIADIYGRKPIMIFSMasnallmlgFLFIEGFIPYA---------ILSIFLGLSNSLFHPAASAMVADV 129
Cdd:cd17323 45 LGFGLGPLIWAPLSELYGRRPVYLVSL---------FIFVIFQIGCAlapniamliILRFLQGFFGSSPLAIGAGTIADL 115
|
90 100
....*....|....*....|....*....
gi 1104416264 130 TAPEKRTEAYGLLRMGHNIGAAIGPIMGA 158
Cdd:cd17323 116 FTPEERGKAMGVYSLGPLLGPALGPIIGG 144
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
12-153 |
2.90e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.03 E-value: 2.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 12 DRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNAL 90
Cdd:cd17503 177 DRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGySAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLAL 256
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 91 LMLGFLFIE---GFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIG 153
Cdd:cd17503 257 GTLLLAFLTpdtSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
49-222 |
2.91e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 45.83 E-value: 2.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 49 EVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVAD 128
Cdd:TIGR00881 31 DLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 129 VTAPEKRTEAYGLLRMGHNIGAAIGP--IMGASVVVLSKNLVFIIASSTMLFYALLVLLLIQET------------MPKR 194
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSpqscglppaeemPNEE 190
|
170 180
....*....|....*....|....*...
gi 1104416264 195 TDKEEHKEKESGAVWKIVMRDKALMIYL 222
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQYVLLNKVL 218
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
286-402 |
3.11e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 45.57 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 286 KTMLYGACLFGIGLFFIGWLPkwfgefntnATIILITLLFVYAIytlGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQW 365
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAP---------SPELLIAARALQGI---GAGGLMPGALALIAELFPARERGRALGLWGAAI 147
|
90 100 110
....*....|....*....|....*....|....*..
gi 1104416264 366 ITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:COG0477 148 GLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
46-161 |
4.81e-05 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 45.51 E-value: 4.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 46 SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMI----FSMASNALLMLgfLFIEGFI-PYAIL-SIFL-GLSNSLF 118
Cdd:pfam05977 43 SPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLagqlLLALVSTLLTL--LAGLGLLsPWLLLgLTFLgGIGTALM 120
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1104416264 119 HPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV 161
Cdd:pfam05977 121 DPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLL 163
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
13-153 |
4.95e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.86 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 13 RNVWIRFIGETLNGIAMMMLMPFFALYLKD-KVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGR-KPIMIFSMASNAL 90
Cdd:cd17502 167 RTILLSSIFGFLFGGALFGLIYYLPLYFQLvLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRyKPLIVIGTILMSV 246
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104416264 91 LMLGFLFIEGFIP---YAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIG 153
Cdd:cd17502 247 GAGLLTTLTLDTSkwlLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG 312
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
27-404 |
5.45e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 44.90 E-value: 5.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 27 IAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYG-RKPIMIFSMASNALLMLGFLFIEGFIPYA 105
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 106 ILSIFLGLSNSlFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALLVL 184
Cdd:cd17490 90 IARFLSGIAAA-TWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAeHFGMRAPFLLAALAGVLGFILSL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 185 LLIQETMPKRTDKEEHKEKESgavwkiVMRDKALMIY-LLAGIIISMGFSQTEGMLPLHfdneMKRIFGTNNPYPYLMAL 263
Cdd:cd17490 169 FIKEERREKKPVLTELKELLS------VLKDKKLLFFsLLAILQQMITFSTTFGFTPLI----AKQLGASSFQLGLLSII 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 264 NGLLVVLFQ-FQISKWATDKPVGKTMLYGACLFGIGLFFIGWLPKwfgefntnatiiLITLLFVYAIYTLGEMIMSPVQM 342
Cdd:cd17490 239 YLLPNALASlLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPN------------LTLLYLLQALNGFGTGILFPLLM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104416264 343 TFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYV 404
Cdd:cd17490 307 SLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-163 |
1.14e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.10 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 49 EVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVAD 128
Cdd:cd17319 39 QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAE 118
|
90 100 110
....*....|....*....|....*....|....*
gi 1104416264 129 VTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVL 163
Cdd:cd17319 119 WFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL 153
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-136 |
1.36e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.72 E-value: 1.36e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104416264 63 FGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRT 136
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRS 113
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
16-178 |
1.48e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 43.75 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 16 WIRFIGETLNGIAMMMLMPFFALYLKDKV-DSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLG 94
Cdd:cd17353 216 WLLWLMFFLNATAGLMLIGQAKPIGQEFAgLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 95 FLFI-EGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIA 172
Cdd:cd17353 296 LPFIgSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLyTGGYNAAFIIA 375
|
....*.
gi 1104416264 173 SSTMLF 178
Cdd:cd17353 376 AALSLV 381
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
51-222 |
1.68e-04 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 43.56 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 51 GVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALlMLGFLFIEGFIPYAILSIFlGLSNSLFhPAASAMVADVT 130
Cdd:cd17387 39 GLVQGVKGILSFLSAPLIGALSDVWGRKSFLLLTVFFTCA-PIPLMRISPWWYFAMISVS-GIFSVTF-SVIFAYVADIT 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 131 APEKRTEAYGLLRMGHNIGAAIGPIMGASVV-VLSKNLVFIIASSTMLFYALLVLLLIQETMPKRTDKEEHKEKESG--- 206
Cdd:cd17387 116 TEEERSTAYGLVSATFAASLVTSPALGAYLSeSYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAPISWeqa 195
|
170 180
....*....|....*....|
gi 1104416264 207 ---AVWKIVMRDK-ALMIYL 222
Cdd:cd17387 196 dpfASLRKVGKDKtVLLICI 215
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
48-401 |
2.29e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 42.94 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 48 LEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVA 127
Cdd:cd17359 36 FLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 128 DVTAPEKRTEAYGLLRMGHNIG--------AAIGPIMGASVVVLSknlvfiiASSTMLFYAL---LVLLLIQETMPkrtd 196
Cdd:cd17359 116 EVAPAEIRGRLVSLNQLMIVFGqllayivnYLIANAGGADWLGAE-------GWRWMLGLEAipaILFLLGMLFIP---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 197 keehkekESGAvWKIVMRDKALMIyllaGIIISMgFSQTEGM-LPLHFDNEM-KRIFGTNNPYPYLMALNGLLVVLFQFq 274
Cdd:cd17359 185 -------ESPR-WLVSKGKPILII----GIGLAI-FQQFVGInVIFYYGPEIfQNAGFSENAALLQTIGIGVVNVIFTI- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 275 ISKWATDKpVG--KTMLYGACLFGIGLFFIGWLPKWFGEFNTNATIILITLLFVYAIYtlgEMIMSPVQMTFVANLAPEH 352
Cdd:cd17359 251 IAILLVDK-VGrkPLLLIGSIGMAISLLLIGTAFYFAPGSQASGIVALVLILLFVAFF---AMSWGPVTWVLLSEIFPNR 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1104416264 353 LRGTYMG-AASLQWItGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGI 401
Cdd:cd17359 327 IRGLAMGiAVFFLWI-ANFLVSLTFPILLAAFGLAFTFLIFAVICVLAFL 375
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-404 |
3.03e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 43.03 E-value: 3.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 23 TLNGIAMMM---LMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFS---MASNALLMLGFL 96
Cdd:pfam00083 18 VIGAFLTLIdffKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGAAK 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 97 FIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRteayGLLRMGHNIGAAIGPIMGASVVVLSKN---------- 166
Cdd:pfam00083 98 GKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLR----GALGSLYQLAITFGILLAYIFGLGLNKtsnsdgwrip 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 167 --LVFIIAS------------------------STMLFYALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMI 220
Cdd:pfam00083 174 lgLQLVPALlliigllflpesprwlvekgrleeAREVLAKLRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 221 YLLAGIIIsMGFSQTEGMlpLHFDNEMKRIFGTNNPYPYLMALNGLLVVLFQFQISKWATDKPVG--KTMLYGACLFGIG 298
Cdd:pfam00083 254 RLLIGVML-QIFQQLTGI--NAIFYYSTTIFENLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGrrPLLLLGAAGMAIC 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 299 LFFIGWLPKWFGEFNTNATIILITLLFVYAiyTLGEMIMSPVQMTFVANLAPEHLRGTYMG-AASLQWItGSAFGPLLGG 377
Cdd:pfam00083 331 FVILGIVALLGVSKSDWAGIVAIVFIALFI--AFFAMGWGPVPWVIVSELFPLSVRSKAMAlATAANWL-ANFLIGFLFP 407
|
410 420
....*....|....*....|....*..
gi 1104416264 378 FLLDRlLGHFLFTILAVGCVVAGIVYV 404
Cdd:pfam00083 408 IITDA-IGLGYTFFIFAGLLVLFIIFV 433
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
21-325 |
3.06e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 42.98 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 21 GETLNGIAMMMLMPFFALYLKDKVD-SLLEVGVIMALSPIAASFGSLIGGRIAD----IYG-RKPIMIFSMASNALL--- 91
Cdd:cd17332 7 GDFGNNLIFQIVSTYLLFFYTDVLGlSAAAAGTIFLVARIIDAINDPLMGYLIDrtrsRWGrFRPWLLWGAIPLALLfvl 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 92 ---MLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTA-PEKRTEAYGLLRMGHNIG------------AAIGPI 155
Cdd:cd17332 87 lftTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDdPEERTSLTSWRMFFATIGgllvtvlppplvAYFGGG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 156 MGASVVVLSKNLVFIIASSTMLFYALLVLLLIQetmPKRTDKEEHKEKESgavWKIVMRDKALMIYLLAGIIISMGFSQT 235
Cdd:cd17332 167 NASRGYFLTALIIGIIGIILLLICFFGTRERVV---PPEEEKSKLPLLKS---LKALLKNRPFLILLLAYLLYFLAFNIV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 236 EGMLPLHFdnemKRIFGTNNpyPYLMALNGLLVVLFQFQISKWATDKPVGKTMLYGACLFGIGLFFIGWlpkWFGEFNTN 315
Cdd:cd17332 241 NTVLVYYF----KYVLGGRA--ELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLL---FFLPPGNL 311
|
330
....*....|
gi 1104416264 316 ATIILITLLF 325
Cdd:cd17332 312 VLILVLAVLA 321
|
|
| PRK10489 |
PRK10489 |
enterobactin transporter EntS; |
19-402 |
4.22e-04 |
|
enterobactin transporter EntS;
Pssm-ID: 236700 [Multi-domain] Cd Length: 417 Bit Score: 42.27 E-value: 4.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGfLFI 98
Cdd:PRK10489 23 FIARFISIFGLGLLGVAVPVQIQMMTGSTLQVGLSVTLTGGAMFIGLMVGGVLADRYDRKKLILLARGTCGLGFIG-LAL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 99 EGFIP----YAI--LSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVVLSK-NLVFII 171
Cdd:PRK10489 102 NAFLPepslLAIylLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITMLTVRLGSVISPALGGLLIAAGGvAWNYGL 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 172 ASSTMLfyALLVLLLIQETMPKRTDKEEHKEKESGAVWKIVMRDKALMIYLLAGIIISMgFSQTEGMLPLHFDNemkrIF 251
Cdd:PRK10489 182 AAAGTF--ITLLPLLRLPALPPPPQPREHPLRSLLAGFRFLLASPVVGGIALLGGLLTM-ASAVRVLYPALADE----VW 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 252 GTNNPYPYLM----ALNGLLVVLFQFQISKWAtdKPvGKTMLYGACLFGIGLFFIGWLPKWfgefntnatiiLITLLFVy 327
Cdd:PRK10489 255 QMGAAQIGLLyaavPLGAALGALTSGWLAHSA--RP-GLLMLLSTLGSFLAVGLFGLMPMW-----------ILAVLCL- 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104416264 328 AIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIV 402
Cdd:PRK10489 320 ALFGYLSAISSLLQYTLLQTQTPDEMLGRINGLWTAQNVTGDAIGAALLGGLGAMMTPVASASASGFGLLIIGVL 394
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
19-180 |
5.38e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.83 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 19 FIGETLNGIAMMMLMPFFALYLKDKVDSLLEV----GVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLG 94
Cdd:PRK09874 225 FVTTLIIQVATGSIAPILTLYVRELAGNVSNIafisGMIASVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIP 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 95 FLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASVVV-LSKNLVFIIAS 173
Cdd:PRK09874 305 MSFVQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISAnYGFRAVFLVTA 384
|
....*..
gi 1104416264 174 STMLFYA 180
Cdd:PRK09874 385 GVVLFNA 391
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
66-157 |
6.48e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.48 E-value: 6.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 66 LIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTE-AYGLLRM 144
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGA 130
|
90
....*....|...
gi 1104416264 145 GHNIGAAIGPIMG 157
Cdd:cd17476 131 TAPLGFALGGVFG 143
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
46-404 |
6.51e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.84 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 46 SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFIPYAILSIFLGLSNSLFH----PA 121
Cdd:cd17345 36 SKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFILLFLNGWFQgmgwPP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 122 ASAMVADVTAPEKRTEAYGLLRMGHNIGAAI-GPIMGASVVVL---SKNLVFIIASSTMLFYALLVLLLIQET-----MP 192
Cdd:cd17345 116 SGRTMVHWFSKKERGTWTSIWNISHNVGGGLvGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTpesegLP 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 193 K----RTDKEEHKEKESGA--------VWKIVMRDKALMIYLLAGIIISM-----------------GFSQTEGMLPLHF 243
Cdd:cd17345 196 PieeyKGDYPEEADGEEEEqelsaweiFVKYVLKNKLLWYIAIANVFVYLvrygildwaptylsevkGFSKAQAMWAFSL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 244 dNEMKRIFGTnnpypylmalngllvvlfqfQISKWATDKPV-GKTMLYG-ACLFGIGLFFIGWlpkwfgEFNTNATIILI 321
Cdd:cd17345 276 -FEWAAIPGT--------------------LLAGWLSDKLFkGRRAPTGiIFMILVIVALIVY------WLAPNVLVDLI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 322 TLLFvyaiytLGEMIMSPVQMTFVA--NLAPEHLRGTYMGAASL-QWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVV 398
Cdd:cd17345 329 ALIA------LGFLIYGPVMLIGLQalELVPKKAAGTAAGLTGLfGYLGGSVLATALIGIIVDHFGWNGGFIVLLASCIL 402
|
....*.
gi 1104416264 399 AGIVYV 404
Cdd:cd17345 403 AIIFLA 408
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
320-412 |
1.13e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 41.21 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 320 LITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTI-LAVGCVV 398
Cdd:TIGR00711 90 LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLInVPIGIIV 169
|
90
....*....|....
gi 1104416264 399 AGIVYVSLDRLVEQ 412
Cdd:TIGR00711 170 VVVAFFILPRDKPA 183
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-405 |
1.23e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.68 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 46 SLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGFiPYAILSIFL-GLSNSLFHPAASA 124
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY-PVLLVLLFLvGAGYGSVQPGGGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 125 MVADVTAPEKRTEAYGLLRMGHNIGAAIGPIMGASV-VVLSKNLVFIIASSTMLFYALLVLLLIQEtmPKRTDKEEHKEK 203
Cdd:cd17475 108 AIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFYRE--PPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 204 ESGAVWKIVMRDKALMIYLLAGIIISMG----------------------------FSQTEGML-----PLHFDnemkRI 250
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIAIAGALLVAPqfalltflllflhdhlglsvvaagallaVAQLGGALgriglGRVSD----RV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 251 FGTNNPYPY--LMALNGLLVVLFQFQiskwatdKPVGKTMLYGACLFGIGLFFIGWLPKWFgefntnatiilitllfvya 328
Cdd:cd17475 262 FGGRRRPVLviTAAIAAAALLVLSLL-------SPGTPLWLLVLLLILLGLFAIGWNGLYL------------------- 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1104416264 329 iytlgemimspvqmTFVANLAPEHLRGTYMGAA-SLQWItGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVAGIVYVS 405
Cdd:cd17475 316 --------------TLVAESAGPEQAGTALGLAnTINFI-GIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
64-161 |
1.68e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.33 E-value: 1.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 64 GSLIGGRIADIYGRKPIMIFSMASNALLMLGFLFIEGF--IPYAILSIFLGLSNSLfhPAASAMVADVTAPEKRTEAYGL 141
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFpsLLVARLLTGVGLGGAL--PNLIALTSEAVGPRLRGTAVSL 143
|
90 100
....*....|....*....|
gi 1104416264 142 LRMGHNIGAAIgpimgASVV 161
Cdd:PRK11551 144 MYCGVPFGGAL-----ASVI 158
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
15-177 |
2.02e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.00 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 15 VWIRFIGETLNGIAMMMLMPFFALYLKDKVDsllEVGVIMALSPIAASFGSLIGGRIADIYGRKPIMIFSMASNALLMLG 94
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVA---DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 95 FLFIEGFIPYAILSIFLGLSNSLFHPAASAMVADVTaPEKRTEAYGLLRMGHNIGAAIGPIMGASVV--VLSKNLVFIIA 172
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLtsELSWSWAYLII 156
|
....*
gi 1104416264 173 SSTML 177
Cdd:cd17333 157 GLIYL 161
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
217-379 |
2.38e-03 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 40.21 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 217 ALMIYLLAGIIISMGFSQTEGMLPLHFDNEMKR-IFGTNNPYPYLMALNGLLVVLFQFQISKWAT-----DKPVGKTMLY 290
Cdd:TIGR00924 273 AYIVLFLEAVVFWVLYAQMPTSLNFFADNNMHHeMLGMSVPVIWFQSLNPFWVVVGSPVLAMIWTrlgrkGKDPTTPLKF 352
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 291 GACLFGIGLFFIGWLPK-WFGEFNTNATIILITLlfVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAaslqWITGS 369
Cdd:TIGR00924 353 TLGMLFCGASFLTFAASiWFADAGGLTSPWFMVL--IYLFQTLGELMISPLGLSWWTKIAPQRLMGQMLGM----WFLAQ 426
|
170
....*....|
gi 1104416264 370 AFGPLLGGFL 379
Cdd:TIGR00924 427 AMGSLLGGYL 436
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
317-421 |
3.54e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 317 TIILITLLFVYAIYTLGEMIM--------SPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFL 388
Cdd:cd17391 77 AIVIGLMAFVTNVWQLLILRLlqgvfsgyVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNV 156
|
90 100 110
....*....|....*....|....*....|....*.
gi 1104416264 389 FTI---LAVGCVVAGIVYVSLDRLVEQRQKDTLTKQ 421
Cdd:cd17391 157 FFItggLLFLAFLLTLFFVKEDFKPVEKKKMVSTKE 192
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
66-152 |
4.69e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 66 LIGGRIADIYGRKPIMIFSMASNALL-MLGFLFIE-GFIPYAILSIFLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLR 143
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLtLLTPLAARgGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAY 153
|
....*....
gi 1104416264 144 MGHNIGAAI 152
Cdd:cd17318 154 SGSQFGTVI 162
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
320-399 |
5.39e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 320 LITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTILAVGCVVA 399
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILA 163
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
4-118 |
5.45e-03 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 39.14 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 4 TWRELREM--DRNVWIRFIGETLN-GIAMMMLMPFFALYLKD-KVDSLLEVGVIMALSPIAASFGSLIGGRIA--DI-YG 76
Cdd:PRK08633 221 LWRNLKLLrsDRVLWLAIIGLSYFwFISQLAQANFPAYAKEVlGLDNTFQVQYLLAASAIGIGIGSLLAGRLSgrHIeLG 300
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1104416264 77 RKPIMIFSMASNALLmlgFLFIEGFIPYAILSIFLGLSNSLF 118
Cdd:PRK08633 301 LVPLGALGLALSLFL---LPTAPSLASVLVLFFLFGFSAGLF 339
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
320-402 |
8.28e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 37.93 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 320 LITLLFVYAIYTLGEMIMSPVQMTFVANLAPEHLRGTYMGAASLQWITGSAFGPLLGGFLLDRLLGHFLFTI-LAVGCVV 398
Cdd:cd17502 83 MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInLPIGGLA 162
|
....
gi 1104416264 399 AGIV 402
Cdd:cd17502 163 LALL 166
|
|
| PRK03633 |
PRK03633 |
putative MFS family transporter protein; Provisional |
5-179 |
9.59e-03 |
|
putative MFS family transporter protein; Provisional
Pssm-ID: 179614 [Multi-domain] Cd Length: 381 Bit Score: 38.10 E-value: 9.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 5 WRELREmdRNVWIRFIGETLNGIAMMMLMPFFALYLKDKVDSLLEVGVIMALSPIAASFGSLIGGRIADIYGRKPIM--- 81
Cdd:PRK03633 194 WPMLKL--RQARLGVNGCIISGIVLGSLYGLMPLYLNHQGMSDASIGFWMALLVSAGILGQWPIGRLADRFGRLLVLrvq 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104416264 82 IFSMASNALLMLG------FLFIegfipyailsifLGLSNSLFHPAASAMVADVTAPEKRTEAYGLLRMGHNIGAAIGPI 155
Cdd:PRK03633 272 VFVVILGSIAMLSqaamapALFI------------LGAAGFTLYPVAMAWACEKVEHHELVAMNQALLLSYTVGSLLGPS 339
|
170 180
....*....|....*....|....*
gi 1104416264 156 MGASVV-VLSKNLVFIIASSTMLFY 179
Cdd:PRK03633 340 FTAMLMqNYSDNLLFIMIASVSFIY 364
|
|
| |
