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Conserved domains on  [gi|1104421624|ref|WP_071745380|]
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serine hydrolase [Bacillus proteolyticus]

Protein Classification

serine hydrolase domain-containing protein( domain architecture ID 10004149)

class C beta-lactamase-related serine hydrolase similar to Flavobacterium 6-aminohexanoate-dimer hydrolase, which degrades linear oligomers of 6-aminohexanoate by exo-type cleavage, removing residues sequentially from the N-terminus of nylon-6 oligomers

CATH:  3.40.710.10
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  31155436|34986744
SCOP:  3001604

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
94-392 7.36e-82

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


:

Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 255.38  E-value: 7.36e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624  94 PAEGPPQEINE-NAQLDQYLQNTGFSGTAV-IVKNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKD 171
Cdd:COG1680     8 PAAGLSADLAAlDAALDAALAEGGIPGAAVaVVRDGKVVYEKAYGVADLETGRPVTPDTLFRIASVTKSFTATAVLQLVE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 172 QNKLQVEDTIAKYIPDFPQ----GNSIQLKHLLTHTSGIPEYEQG-------TEDISHEELIKRIGNQKRIAGPGEKWKY 240
Cdd:COG1680    88 EGKLDLDDPVSKYLPEFKLpddaKRDITVRHLLTHTSGLPDYEPDpydaadvARPYTPDDLLARLAALPLLFEPGTRFSY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 241 SDSNYSILAYIAEKVSGQPLEEYIEQHIFAIAGMKHSGFGKALEQTRFPSTGYKIVNNNMTTPNIpsMSQLYGCGDIYTS 320
Cdd:COG1680   168 SNLGYDLLGEIIERVTGQPLEDYLRERIFEPLGMTDTGFGLPDAEAARLAPGYEADGEVHDAPAW--LGAVAGAGGLFST 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 321 AHDLYLFNEALFSG------KLISKESYNQMFTAVKKD------YGFGWYV----DPGSYSNHGVMPGWNCLNGFSKNGS 384
Cdd:COG1680   246 ARDLARFGQALLNGgewdgkRLLSPETLAEMTTPQVPSgdagggYGLGWWLnddgGSGSFGHGGATPGFSTFLWVDPERG 325


                  ....*...
gi 1104421624 385 VYVVLLSN 392
Cdd:COG1680   326 LGVVVLTN 333
tolA super family cl35847
cell envelope integrity inner membrane protein TolA; Provisional
 44-108 1.97e-05

cell envelope integrity inner membrane protein TolA; Provisional


The actual alignment was detected with superfamily member PRK09510:

Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 46.34  E-value: 1.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104421624  44 KKEETLKAVAEMK----KQEEIKKQEEMKRQEAEK---QRKQKEQEEQIKQAQVIEKPAEGPPQEINENAQL 108
Cdd:PRK09510   76 RAEEQRKKKEQQQaeelQQKQAAEQERLKQLEKERlaaQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147
 
Name Accession Description Interval E-value
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
94-392 7.36e-82

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 255.38  E-value: 7.36e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624  94 PAEGPPQEINE-NAQLDQYLQNTGFSGTAV-IVKNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKD 171
Cdd:COG1680     8 PAAGLSADLAAlDAALDAALAEGGIPGAAVaVVRDGKVVYEKAYGVADLETGRPVTPDTLFRIASVTKSFTATAVLQLVE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 172 QNKLQVEDTIAKYIPDFPQ----GNSIQLKHLLTHTSGIPEYEQG-------TEDISHEELIKRIGNQKRIAGPGEKWKY 240
Cdd:COG1680    88 EGKLDLDDPVSKYLPEFKLpddaKRDITVRHLLTHTSGLPDYEPDpydaadvARPYTPDDLLARLAALPLLFEPGTRFSY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 241 SDSNYSILAYIAEKVSGQPLEEYIEQHIFAIAGMKHSGFGKALEQTRFPSTGYKIVNNNMTTPNIpsMSQLYGCGDIYTS 320
Cdd:COG1680   168 SNLGYDLLGEIIERVTGQPLEDYLRERIFEPLGMTDTGFGLPDAEAARLAPGYEADGEVHDAPAW--LGAVAGAGGLFST 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 321 AHDLYLFNEALFSG------KLISKESYNQMFTAVKKD------YGFGWYV----DPGSYSNHGVMPGWNCLNGFSKNGS 384
Cdd:COG1680   246 ARDLARFGQALLNGgewdgkRLLSPETLAEMTTPQVPSgdagggYGLGWWLnddgGSGSFGHGGATPGFSTFLWVDPERG 325


                  ....*...
gi 1104421624 385 VYVVLLSN 392
Cdd:COG1680   326 LGVVVLTN 333
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
 108-404 3.24e-61

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 201.19  E-value: 3.24e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 108 LDQYLQNTGFSGTAVIV-KNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKDQNKLQVEDTIAKYIP 186
Cdd:pfam00144   5 IRELMAQGGIPGVAVAVtRDGKVVVDRGGGVADLEGGRPVTADTLFRIASVTKTFTAAAVLQLVERGKLDLDDPVSKYLP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 187 DF--PQGNSIQLKHLLTHTSGIPEYEQGTEDIS----HEELIKRIGNQKRIAGPGEKWKYSDSNYSILAYIAEKVSGQPL 260
Cdd:pfam00144  85 EFagPGKGGITLRDLLTHTSGLPPLFAPDDLEEaaadAAELVRALAALPPVWPPGTRWGYSNTAYGLLGELLERVTGQSY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 261 EEYIEQHIFAIAGMKHSGFGKALEQTRFPSTGYKIvnNNMTTPNIPSMSQLYGCGDIYTSAHDLYLFNEALFSGKLISKE 340
Cdd:pfam00144 165 EELLGDRILRPLGMTDTELGVPEPGDPRDAAGYTG--EGPPVRVPPGPLPAGAYGGLKSTARDLARFLLALLGGLLLSAA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 341 SYNQMFTAVK----------KDYGFGWYVD------PGSYSNHGvmpGWNCLNGFSKNGSVYVVLLSNIQNNIKSFGKVN 404
Cdd:pfam00144 243 ALAQLTDWLRggttgvggirAGLGLGWVLAdktgagPGLFGHTG---GYGTYLAVDPDIGLVVVVLSNRLGPNPDAAEDA 319
PRK03642 PRK03642
putative periplasmic esterase; Provisional
 107-360 1.63e-22

putative periplasmic esterase; Provisional


Pssm-ID: 179620 [Multi-domain]  Cd Length: 432  Bit Score: 98.71  E-value: 1.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 107 QLDQYLQN---TGFSGTA-VIVKNGKVLLNKGYGMANK-------EKQVPNNSETTFYIGSISKAFVATTIMQ-LKDQNK 174
Cdd:PRK03642   42 QMDRWISQqidAGYPGVNlLIIKDNQIVYRKAWGYAKKydgstllAHPVKATTNTMYDLASNTKMYATNFALQkLVSEGK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 175 LQVEDTIAKYIPDFP-------QG-NSIQLKHLLTHTSGIPE-------------YEQgtEDISHEELIKRIGNQKRiag 233
Cdd:PRK03642  122 LDVNDLISKYIPGFKdspgdkiKGkNTLRIIDLLHHSAGFPAdpqypnkavagalYSQ--DKSTTLEMIKKTPLEYQ--- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 234 PGEKWKYSDSNYSILAYIAEKVSGQPLEEYIEQHIFAIAGMKHSGFG---KALEQTRFPSTgyKIVNNN----MTTPNIP 306
Cdd:PRK03642  197 PGSKHIYSDVDYMLLGFIVESITGQPLDRYVEESIYRPLGLTHTVFNplqKGFKPQQIAAT--ELNGNTrdgvIHFPNIR 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104421624 307 ---------------SMSQLYGCGDIYTSAHDLYLFNEALFSG------KLISKESYNQMFTAVKKD--YGFGWYVD 360
Cdd:PRK03642  275 tntlwgqvhdekafySMGGVSGHAGLFSNTGDMAVLMQVMLNGggygnvQLFDAETVKMFTTSSKEDatFGLGWRVN 351
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 44-108 1.97e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 46.34  E-value: 1.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104421624  44 KKEETLKAVAEMK----KQEEIKKQEEMKRQEAEK---QRKQKEQEEQIKQAQVIEKPAEGPPQEINENAQL 108
Cdd:PRK09510   76 RAEEQRKKKEQQQaeelQQKQAAEQERLKQLEKERlaaQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 44-96 7.35e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 7.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624  44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:TIGR02794  93 ELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAK 145
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 41-89 1.44e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.79  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1104421624  41 AHNKKEETLKAVAEMKKQeeiKKQEEMKRQEAEKQRkQKEQEEQIKQAQ 89
Cdd:pfam15709 421 ARQQQEEFRRKLQELQRK---KQQEEAERAEAEKQR-QKELEMQLAEEQ 465
 
Name Accession Description Interval E-value
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
94-392 7.36e-82

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 255.38  E-value: 7.36e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624  94 PAEGPPQEINE-NAQLDQYLQNTGFSGTAV-IVKNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKD 171
Cdd:COG1680     8 PAAGLSADLAAlDAALDAALAEGGIPGAAVaVVRDGKVVYEKAYGVADLETGRPVTPDTLFRIASVTKSFTATAVLQLVE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 172 QNKLQVEDTIAKYIPDFPQ----GNSIQLKHLLTHTSGIPEYEQG-------TEDISHEELIKRIGNQKRIAGPGEKWKY 240
Cdd:COG1680    88 EGKLDLDDPVSKYLPEFKLpddaKRDITVRHLLTHTSGLPDYEPDpydaadvARPYTPDDLLARLAALPLLFEPGTRFSY 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 241 SDSNYSILAYIAEKVSGQPLEEYIEQHIFAIAGMKHSGFGKALEQTRFPSTGYKIVNNNMTTPNIpsMSQLYGCGDIYTS 320
Cdd:COG1680   168 SNLGYDLLGEIIERVTGQPLEDYLRERIFEPLGMTDTGFGLPDAEAARLAPGYEADGEVHDAPAW--LGAVAGAGGLFST 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 321 AHDLYLFNEALFSG------KLISKESYNQMFTAVKKD------YGFGWYV----DPGSYSNHGVMPGWNCLNGFSKNGS 384
Cdd:COG1680   246 ARDLARFGQALLNGgewdgkRLLSPETLAEMTTPQVPSgdagggYGLGWWLnddgGSGSFGHGGATPGFSTFLWVDPERG 325


                  ....*...
gi 1104421624 385 VYVVLLSN 392
Cdd:COG1680   326 LGVVVLTN 333
Beta-lactamase pfam00144
Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 ...
 108-404 3.24e-61

Beta-lactamase; This family appears to be distantly related to pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 395092 [Multi-domain]  Cd Length: 327  Bit Score: 201.19  E-value: 3.24e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 108 LDQYLQNTGFSGTAVIV-KNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKDQNKLQVEDTIAKYIP 186
Cdd:pfam00144   5 IRELMAQGGIPGVAVAVtRDGKVVVDRGGGVADLEGGRPVTADTLFRIASVTKTFTAAAVLQLVERGKLDLDDPVSKYLP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 187 DF--PQGNSIQLKHLLTHTSGIPEYEQGTEDIS----HEELIKRIGNQKRIAGPGEKWKYSDSNYSILAYIAEKVSGQPL 260
Cdd:pfam00144  85 EFagPGKGGITLRDLLTHTSGLPPLFAPDDLEEaaadAAELVRALAALPPVWPPGTRWGYSNTAYGLLGELLERVTGQSY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 261 EEYIEQHIFAIAGMKHSGFGKALEQTRFPSTGYKIvnNNMTTPNIPSMSQLYGCGDIYTSAHDLYLFNEALFSGKLISKE 340
Cdd:pfam00144 165 EELLGDRILRPLGMTDTELGVPEPGDPRDAAGYTG--EGPPVRVPPGPLPAGAYGGLKSTARDLARFLLALLGGLLLSAA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 341 SYNQMFTAVK----------KDYGFGWYVD------PGSYSNHGvmpGWNCLNGFSKNGSVYVVLLSNIQNNIKSFGKVN 404
Cdd:pfam00144 243 ALAQLTDWLRggttgvggirAGLGLGWVLAdktgagPGLFGHTG---GYGTYLAVDPDIGLVVVVLSNRLGPNPDAAEDA 319
PRK03642 PRK03642
putative periplasmic esterase; Provisional
 107-360 1.63e-22

putative periplasmic esterase; Provisional


Pssm-ID: 179620 [Multi-domain]  Cd Length: 432  Bit Score: 98.71  E-value: 1.63e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 107 QLDQYLQN---TGFSGTA-VIVKNGKVLLNKGYGMANK-------EKQVPNNSETTFYIGSISKAFVATTIMQ-LKDQNK 174
Cdd:PRK03642   42 QMDRWISQqidAGYPGVNlLIIKDNQIVYRKAWGYAKKydgstllAHPVKATTNTMYDLASNTKMYATNFALQkLVSEGK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 175 LQVEDTIAKYIPDFP-------QG-NSIQLKHLLTHTSGIPE-------------YEQgtEDISHEELIKRIGNQKRiag 233
Cdd:PRK03642  122 LDVNDLISKYIPGFKdspgdkiKGkNTLRIIDLLHHSAGFPAdpqypnkavagalYSQ--DKSTTLEMIKKTPLEYQ--- 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 234 PGEKWKYSDSNYSILAYIAEKVSGQPLEEYIEQHIFAIAGMKHSGFG---KALEQTRFPSTgyKIVNNN----MTTPNIP 306
Cdd:PRK03642  197 PGSKHIYSDVDYMLLGFIVESITGQPLDRYVEESIYRPLGLTHTVFNplqKGFKPQQIAAT--ELNGNTrdgvIHFPNIR 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1104421624 307 ---------------SMSQLYGCGDIYTSAHDLYLFNEALFSG------KLISKESYNQMFTAVKKD--YGFGWYVD 360
Cdd:PRK03642  275 tntlwgqvhdekafySMGGVSGHAGLFSNTGDMAVLMQVMLNGggygnvQLFDAETVKMFTTSSKEDatFGLGWRVN 351
ampC PRK11289
beta-lactamase/D-alanine carboxypeptidase; Provisional
 119-277 2.69e-21

beta-lactamase/D-alanine carboxypeptidase; Provisional


Pssm-ID: 236894  Cd Length: 384  Bit Score: 94.57  E-value: 2.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 119 GTAV-IVKNGKV-LLNkgYGMANKEKQVPNNSETTFYIGSISKAFVAT--TIMQLKDqnKLQVEDTIAKYIPDF--PQGN 192
Cdd:PRK11289   50 GMAVaVIYNGKPyYFN--YGVADKATGQPVTQDTLFELGSVSKTFTATlaGYAQARG--ELSLSDPASKYLPELkgSPFD 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 193 SIQLKHLLTHTSG-----IPEyeQGTEDishEELIKRIGNQKRIAGPGEKWKYSDSNYSILAYIAEKVSGQPLEEYIEQH 267
Cdd:PRK11289  126 GITLLHLATYTAGglplqVPD--EVKDD---AQLLRYFQAWQPAYAPGTQRLYSNPSIGLFGYLAAKAMGQPFEQLMEQR 200

                         170
                  ....*....|
gi 1104421624 268 IFAIAGMKHS 277
Cdd:PRK11289  201 LFPPLGLTHT 210
PRK10662 PRK10662
beta-lactam binding protein AmpH; Provisional
 109-279 2.72e-18

beta-lactam binding protein AmpH; Provisional


Pssm-ID: 236732 [Multi-domain]  Cd Length: 378  Bit Score: 85.85  E-value: 2.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 109 DQYLQ----NTGFSGTAVIVKNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKDQNKLQVEDTIAKY 184
Cdd:PRK10662   36 DRYAEhifyGSGATGMALVVIDGNQRVFRSYGETRPGNNVRPQLDSLIRIASITKLMTSEVLVKLADDGTVKLTDPLSKY 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 185 ------IPDFpQGNSIQLKHLLTHTSGIPEyEQGTED--------ISHEELIKRIGNQKRIAGPGEKWKYSDSNYSILAY 250
Cdd:PRK10662  116 appgarVPTY-NGQPITLLNLATHTSALPR-EQPGGAahrpvfvwPTREQRWKWLSTAKLKAAPGTQAAYSNLAFDLLAD 193

                         170       180
                  ....*....|....*....|....*....
gi 1104421624 251 IAEKVSGQPLEEYIEQHIFAIAGMKHSGF 279
Cdd:PRK10662  194 ALAKAAGKPYTQLLREKITRPLGMKDTTF 222
PRK13128 PRK13128
D-aminopeptidase; Reviewed
 116-275 1.29e-15

D-aminopeptidase; Reviewed


Pssm-ID: 171868 [Multi-domain]  Cd Length: 518  Bit Score: 78.36  E-value: 1.29e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 116 GFSGTAVIVKNGKVLLNKGYGMANKEKQVPNNSETTFYIGSISKAFVATTIMQLKDQNKlQVEDTIAKYIPDFpQGNSIQ 195
Cdd:PRK13128   22 GPGGAVAVVKDGEVVLRHAWGFADLARRKAMTPETRMPICSVSKQFTCAVLLDCIGEPE-MLDAALAAYLDQF-EDPRPA 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624 196 LKHLLTHTSGIPEYE-----QGTEDishEELIKRIGNQKRIAG-------PGEKWKYSDSNYSILAYIAEKVSGQPLEEY 263
Cdd:PRK13128  100 VRDLCNNQSGLRDYWaltvlCGAAP---EGIFLPDQAQNLLRRlktthfaPGTHYSYCNGNFRILADLIEQHTGRSLADL 176

                         170
                  ....*....|..
gi 1104421624 264 IEQHIFAIAGMK 275
Cdd:PRK13128  177 LAERIFAPAGMK 188
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 44-108 1.97e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 46.34  E-value: 1.97e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104421624  44 KKEETLKAVAEMK----KQEEIKKQEEMKRQEAEK---QRKQKEQEEQIKQAQVIEKPAEGPPQEINENAQL 108
Cdd:PRK09510   76 RAEEQRKKKEQQQaeelQQKQAAEQERLKQLEKERlaaQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 44-96 7.35e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 7.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624  44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:TIGR02794  93 ELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAK 145
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 41-89 1.44e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 43.79  E-value: 1.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1104421624  41 AHNKKEETLKAVAEMKKQeeiKKQEEMKRQEAEKQRkQKEQEEQIKQAQ 89
Cdd:pfam15709 421 ARQQQEEFRRKLQELQRK---KQQEEAERAEAEKQR-QKELEMQLAEEQ 465
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 46-90 3.87e-04

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 40.79  E-value: 3.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1104421624  46 EETLKAVAEMKKQ-EEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQV 90
Cdd:pfam05672  10 EEAARILAEKRRQaREQREREEQERLEKEEEERLRKEELRRRAEEE 55
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 3.97e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 3.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRK---QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKAdeaKKKAEEAKKKADAAKKKAE 1339
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 5.01e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 5.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1510 KKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE 1562
PTZ00121 PTZ00121
MAEBL; Provisional
 44-176 6.49e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624   44 KKEETLKAVAEM---KKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAEGPPQE------INENAQLDQYLQN 114
Cdd:PTZ00121  1723 KAEEENKIKAEEakkEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEeldeedEKRRMEVDKKIKD 1802

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1104421624  115 TgFSGTAVIVKNGkvllnkgygmaNKEKQVPNNSETTFYigSISKAFVATTIMQLKDQNKLQ 176
Cdd:PTZ00121  1803 I-FDNFANIIEGG-----------KEGNLVINDSKEMED--SAIKEVADSKNMQLEEADAFE 1850
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 7.07e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.05  E-value: 7.07e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1504 KAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE 1556
PTZ00121 PTZ00121
MAEBL; Provisional
 38-96 8.69e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 8.69e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1104421624   38 KIVAHNKKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1330 KADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAE 1388
SKIP_SNW pfam02731
SKIP/SNW domain; This domain is found in chromatin proteins.
 52-82 9.64e-04

SKIP/SNW domain; This domain is found in chromatin proteins.


Pssm-ID: 460666  Cd Length: 152  Bit Score: 39.48  E-value: 9.64e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1104421624  52 VAEMKKQEEIKKQEEMKRQEAEKQRKQKEQE 82
Cdd:pfam02731 111 IAERKAREEVKLRAEMQKKLAEKEKEEKEEK 141
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 43-107 1.01e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 40.98  E-value: 1.01e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624  43 NKKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQ-----KEQEEQIKQAQVIEKPAEGPPQEINENAQ 107
Cdd:TIGR02794  57 QQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKeleqrAAAEKAAKQAEQAAKQAEEKQKQAEEAKA 126
PTZ00121 PTZ00121
MAEBL; Provisional
 41-96 1.05e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 1.05e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624   41 AHNKKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADE 1550
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 46-101 1.43e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.87  E-value: 1.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624  46 EETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQaqviEKPAEGPPQE 101
Cdd:pfam05672  61 EEARRLEEERRREEEERQRKAEEEAEEREQREQEEQERLQKQ----KEEAEAKARE 112
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 1.44e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.28  E-value: 1.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQ---KEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1373 KEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAdelKKAAAAKKKADEAKKKAE 1428
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 1.57e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.57e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRkqKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALK--KEAEEAKKAEELKKKEAE 1713
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 1.60e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.60e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRK----QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1684 EEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKaeelKKAEEENKIKAEEAKKEAE 1740
PTZ00121 PTZ00121
MAEBL; Provisional
 44-108 1.70e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 1.70e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAEGPPQEINENAQL 108
Cdd:PTZ00121  1516 KKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMAL 1580
PTZ00121 PTZ00121
MAEBL; Provisional
 41-165 2.28e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624   41 AHNKKEETLKAVAEMKKQ--EEIKKQEEMKRQEAEKQRK----QKEQEEQIKQAQVIEKpAEGPPQEINENAQLDQYLQN 114
Cdd:PTZ00121  1693 ALKKEAEEAKKAEELKKKeaEEKKKAEELKKAEEENKIKaeeaKKEAEEDKKKAEEAKK-DEEEKKKIAHLKKEEEKKAE 1771

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104421624  115 TGFSGTAVIVKNGKVLLNKGYGM----------ANKEKQVPNNSETTFYIGSISKAFVATT 165
Cdd:PTZ00121  1772 EIRKEKEAVIEEELDEEDEKRRMevdkkikdifDNFANIIEGGKEGNLVINDSKEMEDSAI 1832
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 44-110 2.43e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.48  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624  44 KKEETLKAVAEMKKQ---EEIKKQEEMKRQEAEKQRKQKEQEEQikqaQVIEKPAEGPPQEINENAQLDQ 110
Cdd:pfam05672  36 EKEEEERLRKEELRRraeEERARREEEARRLEEERRREEEERQR----KAEEEAEEREQREQEEQERLQK 101
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
 44-86 2.55e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 39.47  E-value: 2.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1104421624  44 KKEETLKAVAEMKKQEEIK-KQEEMKRQE---------AEKQRK--QKEQEEQIK 86
Cdd:pfam07946 268 EEIEKIKKAAEEERAEEAQeKKEEAKKKEreeklaklsPEEQRKyeEKERKKEQR 322
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 46-104 2.87e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 39.44  E-value: 2.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104421624  46 EETLKAVAEMKKQEE----IKKQEEMKRQeAEKQRKQKEQEEQIKQAQVIEKPAEGPPQEINE 104
Cdd:TIGR02794 123 EAKAKQAAEAKAKAEaeaeRKAKEEAAKQ-AEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAE 184
Caldesmon pfam02029
Caldesmon;
42-93 3.03e-03

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 39.85  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624  42 HNKKEETLKAVAEMKKQEE----IKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEK 93
Cdd:pfam02029 269 RQKQQEAELELEELKKKREerrkLLEEEEQRRKQEEAERKLREEEEKRRMKEEIER 324
PTZ00121 PTZ00121
MAEBL; Provisional
 41-96 3.35e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.12  E-value: 3.35e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1104421624   41 AHNKKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRK---QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAdeaKKKAEEAKKKADEAKKAAE 1507
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 3.44e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1104421624   44 KKEETLKAVAEMKKQEE-IKKQEEMKRQEAEKQRK----QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1669 KAEEDKKKAEEAKKAEEdEKKAAEALKKEAEEAKKaeelKKKEAEEKKKAEELKKAEE 1726
Pinin_SDK_memA pfam04696
pinin/SDK/memA/ protein conserved region; Members of this family have very varied ...
 44-92 3.52e-03

pinin/SDK/memA/ protein conserved region; Members of this family have very varied localizations within the eukaryotic cell. pinin is known to localize at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque. SDK2/3 is a dynamically localized nuclear protein thought to be involved in modulation of alternative pre-mRNA splicing. memA is a tumour marker preferentially expressed in human melanoma cell lines. A common feature of the members of this family is that they may all participate in regulating protein-protein interactions.


Pssm-ID: 461396 [Multi-domain]  Cd Length: 130  Bit Score: 37.27  E-value: 3.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624  44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEK----QRKQKEQEEQIKQAQVIE 92
Cdd:pfam04696  22 KKEESKQKEKEERRAEIEKRLEEKAKQEKEEleerKREEREELFEERRAEQIE 74
PTZ00121 PTZ00121
MAEBL; Provisional
 41-96 3.81e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 3.81e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1104421624   41 AHNKKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQ---KEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKAdeaKKKAEEAKKADEAKKKAE 1454
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 44-96 3.83e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.40  E-value: 3.83e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1104421624  44 KKEETLKAVAE--MKKQEEIKKQEEMKRQEAEKQrKQKEqEEQIKQAQVIEKPAE 96
Cdd:PRK09510   98 AEQERLKQLEKerLAAQEQKKQAEEAAKQAALKQ-KQAE-EAAAKAAAAAKAKAE 150
PTZ00121 PTZ00121
MAEBL; Provisional
 38-96 4.34e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.74  E-value: 4.34e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104421624   38 KIVAHNKKEETLKAVAEMKKQEE--IKKQEEMKRQEAEKQRKQ--KEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1379 KADAAKKKAEEKKKADEAKKKAEedKKKADELKKAAAAKKKADeaKKKAEEKKKADEAKKKAE 1441
PTZ00121 PTZ00121
MAEBL; Provisional
 44-102 4.49e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 39.35  E-value: 4.49e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1104421624   44 KKEETLKAVAEMKKQ-EEIKKQEEMKRQEAEKQRK----QKEQEEQIKQAQVIEKPAEGPPQEI 102
Cdd:PTZ00121  1296 KKAEEKKKADEAKKKaEEAKKADEAKKKAEEAKKKadaaKKKAEEAKKAAEAAKAEAEAAADEA 1359
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 44-96 4.50e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 39.06  E-value: 4.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1104421624  44 KKEEtlkAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:TIGR02794 134 AKAE---AEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKA 183
PTZ00121 PTZ00121
MAEBL; Provisional
 44-92 6.01e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 6.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRKQKEQEE--QIKQAQVIE 92
Cdd:PTZ00121  1546 KKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEakKAEEARIEE 1596
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 44-96 6.07e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 38.67  E-value: 6.07e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104421624  44 KKEETLKAVAEMKKQEEI----KKQEEMKRQEAEKQRKQKEQEEQIKQAQVIEKPAE 96
Cdd:TIGR02794 113 QAEEKQKQAEEAKAKQAAeakaKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAE 169
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 6.90e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.97  E-value: 6.90e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1104421624   44 KKEETLKAVAEMKKQEEIKKQEEMKRQEAEKQRK---QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1360 EAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKAdeaKKKAEEDKKKADELKKAAA 1415
PTZ00121 PTZ00121
MAEBL; Provisional
 44-96 9.64e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 38.58  E-value: 9.64e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104421624   44 KKEETLKAVAE-MKKQEEIKKQ-EEMKRQEAEKQRK-----QKEQEEQIKQAQVIEKPAE 96
Cdd:PTZ00121  1613 KKAEEAKIKAEeLKKAEEEKKKvEQLKKKEAEEKKKaeelkKAEEENKIKAAEEAKKAEE 1672
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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