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Conserved domains on  [gi|1104454449|ref|WP_071770866|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Bacillus]

Protein Classification

winged helix-turn-helix transcriptional regulator( domain architecture ID 10004391)

winged helix-turn-helix (HTH) transcriptional regulator containing a HxlR family HTH domain; similar to HTH-type transcriptional regulator HxlR, a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  15808743|10679470|10908318

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 2.31e-38

DNA-binding transcriptional regulator, HxlR family [Transcription];


:

Pssm-ID: 441339  Cd Length: 108  Bit Score: 124.21  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449   1 MEHNSCLCPkFESAFTMLSKKWTGLIIKSLLEEPKRFREIADIIPNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 1104454449  81 VTDKGKALERVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 2.31e-38

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 124.21  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449   1 MEHNSCLCPkFESAFTMLSKKWTGLIIKSLLEEPKRFREIADIIPNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 1104454449  81 VTDKGKALERVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 18-103 3.25e-32

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 108.16  E-value: 3.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449  18 LSKKWTGLIIKSLLEEPKRFREIADIIPNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYGVTDKGKALERVMDEVQN 97
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*.
gi 1104454449  98 WAEKWM 103
Cdd:pfam01638  82 WGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-96 3.55e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.52  E-value: 3.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104454449  26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVRNvypEVPVRIEYGVTDKGKALERVMDEVQ 96
Cdd:cd00090    12 ILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-67 5.57e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 5.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1104454449   26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVR 67
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVES 42
 
Name Accession Description Interval E-value
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
1-104 2.31e-38

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 124.21  E-value: 2.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449   1 MEHNSCLCPkFESAFTMLSKKWTGLIIKSLLEEPKRFREIADIIPNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYG 80
Cdd:COG1733     3 KDLKEADCP-VRRALDVIGGKWKLLILRALLDGPRRFGELRRSLPGISQKMLTQRLRELEEDGLVERTVYPEVPPRVEYS 81

                          90       100
                  ....*....|....*....|....
gi 1104454449  81 VTDKGKALERVMDEVQNWAEKWMK 104
Cdd:COG1733    82 LTEKGRSLLPVLDALAEWGEEHLP 105
HxlR pfam01638
HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts ...
 18-103 3.25e-32

HxlR-like helix-turn-helix; HxlR, a member of this family, is a DNA-binding protein that acts as a positive regulator of the formaldehyde-inducible hxlAB operon in Bacillus subtilis.


Pssm-ID: 460276 [Multi-domain]  Cd Length: 91  Bit Score: 108.16  E-value: 3.25e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449  18 LSKKWTGLIIKSLLEEPKRFREIADIIPNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYGVTDKGKALERVMDEVQN 97
Cdd:pfam01638   2 IGGKWKGLILRELLDGKKRFSELKRAIPGITQKMLTQRLRELEQDGIINREVYPEVPPKVEYSLTEKGRSLEPILQELCD 81


                  ....*.
gi 1104454449  98 WAEKWM 103
Cdd:pfam01638  82 WGEEYL 87
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 26-96 3.55e-06

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 41.52  E-value: 3.55e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1104454449  26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVRNvypEVPVRIEYGVTDKGKALERVMDEVQ 96
Cdd:cd00090    12 ILRLLLEGPLTVSELAERL-GLSQSTVSRHLKKLEEAGLVESR---REGRRVYYSLTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
26-67 5.57e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 35.26  E-value: 5.57e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1104454449   26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVR 67
Cdd:smart00418   2 ILKLLAEGELCVCELAEIL-GLSQSTVSHHLKKLREAGLVES 42
HTH_27 pfam13463
Winged helix DNA-binding domain;
32-85 3.91e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 33.03  E-value: 3.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1104454449  32 EEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVRNVYPEVPVRIEYGVTDKG 85
Cdd:pfam13463  16 GDPKTLADICFRL-NVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
26-102 4.37e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 33.85  E-value: 4.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104454449  26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIV--VRNVYPEVPVRIEYGVTDKG----------KALERVMD 93
Cdd:COG1777    22 ILALLSEEPAYVSELAREL-GVSRQAVYKHLRKLEEAGLVesYREGREDGRARKYYRLSAFRlevtltpdlfARLARELE 100


                  ....*....
gi 1104454449  94 EVQNWAEKW 102
Cdd:COG1777   101 AYRRELSGR 109
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
26-67 8.58e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 33.84  E-value: 8.58e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1104454449  26 IIKSLLEEPKRFREIADIIpNMSDRMLSERLKELEGEGIVVR 67
Cdd:COG3888    11 ILKNYGGEGIPQSELVRLL-GASKSRVSEILSELEKEGLIAR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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