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Conserved domains on  [gi|1119888777|ref|WP_072775017|]
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succinate--CoA ligase subunit alpha [Desulfitobacterium chlororespirans]

Protein Classification

succinate--CoA ligase subunit alpha( domain architecture ID 11414657)

succinate--CoA ligase [ADP/GDP-forming] subunit alpha binds the substrates coenzyme A and phosphate as part of the heterodimeric enzyme succinyl-CoA synthetase that functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP

CATH:  3.40.50.261|3.40.50.720
EC:  6.2.1.5
Gene Ontology:  GO:0000166|GO:0004775|GO:0009361|GO:0006099|GO:0004776
SCOP:  4000071|4000014

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-292 1.13e-146

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


:

Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 412.92  E-value: 1.13e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   2 SIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  82 ILEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLT 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMP---GHIFKPGRVGIVSRSGTLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 162 NEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGlFTKPLIGFMGGR 241
Cdd:COG0074   158 YEAVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN-MTKPVVAYIAGR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1119888777 242 TAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:COG0074   237 TAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-292 1.13e-146

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 412.92  E-value: 1.13e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   2 SIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  82 ILEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLT 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMP---GHIFKPGRVGIVSRSGTLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 162 NEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGlFTKPLIGFMGGR 241
Cdd:COG0074   158 YEAVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN-MTKPVVAYIAGR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1119888777 242 TAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:COG0074   237 TAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-292 2.22e-120

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 346.39  E-value: 2.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   1 MSIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARG 80
Cdd:PRK05678    1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  81 AILEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSL 160
Cdd:PRK05678   81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMP---GHIHKKGRVGVVSRSGTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 161 TNEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLfTKPLIGFMGG 240
Cdd:PRK05678  158 TYEAVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANV-TKPVVGYIAG 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1119888777 241 RTAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:PRK05678  237 VTAPPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVL 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-292 1.66e-110

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 321.29  E-value: 1.66e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   3 IIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGAI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  83 LEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLTN 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMP---GHIHKPGNVGIVSRSGTLTY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 163 EITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLfTKPLIGFMGGRT 242
Cdd:TIGR01019 158 EAVHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNM-SKPVVGFIAGAT 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1119888777 243 APKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:TIGR01019 237 APPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 5-100 2.97e-23

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 91.42  E-value: 2.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777    5 IDQNTPVLIQGITGKEGSFWAKHAK---TYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRnllEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1119888777   82 ILEALDSGIKTIVVTAEGI 100
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 1.74e-22

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 89.19  E-value: 1.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   6 DQNTPVLIQGITGK---EGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGAI 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiqGLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1119888777  83 LEALDSGIKTIVVTAEG 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
 
Name Accession Description Interval E-value
SucD COG0074
Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA ...
 2-292 1.13e-146

Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Succinyl-CoA synthetase, alpha subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 439844 [Multi-domain]  Cd Length: 288  Bit Score: 412.92  E-value: 1.13e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   2 SIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:COG0074     1 SILVNKNTRVIVQGITGKEGSFHTKQMLAYGTNVVAGVTPGKGGQTVLGVPVFDTVAEAVEETGADASVIFVPPPFAADA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  82 ILEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLT 161
Cdd:COG0074    81 ILEAIDAGIKLIVCITEGIPVLDMVRVKRYAKAKGTRLIGPNCPGIITPGECKLGIMP---GHIFKPGRVGIVSRSGTLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 162 NEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGlFTKPLIGFMGGR 241
Cdd:COG0074   158 YEAVWQLTQAGLGQSTCVGIGGDPIIGTSFIDVLELFEEDPETEAIVMIGEIGGSAEEEAAEYIKEN-MTKPVVAYIAGR 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1119888777 242 TAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:COG0074   237 TAPPGKRMGHAGAIISGGKGTAESKIEALEAAGVPVAESPSEIGELLKKAL 287
PRK05678 PRK05678
succinyl-CoA synthetase subunit alpha; Validated
 1-292 2.22e-120

succinyl-CoA synthetase subunit alpha; Validated


Pssm-ID: 180194 [Multi-domain]  Cd Length: 291  Bit Score: 346.39  E-value: 2.22e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   1 MSIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARG 80
Cdd:PRK05678    1 MSILINKDTKVIVQGITGKQGTFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFNTVAEAVEATGANASVIYVPPPFAAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  81 AILEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSL 160
Cdd:PRK05678   81 AILEAIDAGIDLIVCITEGIPVLDMLEVKAYLERKKTRLIGPNCPGIITPGECKIGIMP---GHIHKKGRVGVVSRSGTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 161 TNEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLfTKPLIGFMGG 240
Cdd:PRK05678  158 TYEAVAQLTDLGFGQSTCVGIGGDPINGTNFIDVLEAFEEDPETEAIVMIGEIGGSAEEEAAEYIKANV-TKPVVGYIAG 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1119888777 241 RTAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:PRK05678  237 VTAPPGKRMGHAGAIISGGKGTAEEKKEALEAAGVKVARTPSEIGELLKEVL 288
sucCoAalpha TIGR01019
succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha ...
 3-292 1.66e-110

succinyl-CoA synthetase, alpha subunit; This model describes succinyl-CoA synthetase alpha subunits but does not discriminate between GTP-specific and ATP-specific reactions. The model is designated as subfamily rather than equivalog for that reason. ATP citrate lyases appear to form an outgroup. [Energy metabolism, TCA cycle]


Pssm-ID: 130091 [Multi-domain]  Cd Length: 286  Bit Score: 321.29  E-value: 1.66e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   3 IIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGAI 82
Cdd:TIGR01019   1 ILLDKDTKVIVQGITGSQGSFHTEQMLAYGTNIVGGVTPGKGGTTVLGLPVFDSVKEAVEETGANASVIFVPAPFAADAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  83 LEALDSGIKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLTN 162
Cdd:TIGR01019  81 FEAIDAGIELIVCITEGIPVHDMLKVKRYMEESGTRLIGPNCPGIITPGECKIGIMP---GHIHKPGNVGIVSRSGTLTY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 163 EITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLfTKPLIGFMGGRT 242
Cdd:TIGR01019 158 EAVHQLTKAGFGQSTCVGIGGDPVNGTSFIDVLEAFEKDPETEAIVMIGEIGGSAEEEAADFIKQNM-SKPVVGFIAGAT 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1119888777 243 APKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:TIGR01019 237 APPGKRMGHAGAIISGGKGTAESKIEALEAAGVTVVKSPSDIGELLAEIL 286
PTZ00187 PTZ00187
succinyl-CoA synthetase alpha subunit; Provisional
 5-292 6.53e-89

succinyl-CoA synthetase alpha subunit; Provisional


Pssm-ID: 240307 [Multi-domain]  Cd Length: 317  Bit Score: 267.35  E-value: 6.53e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   5 IDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQD--VDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGAI 82
Cdd:PTZ00187   26 VNKNTKVICQGITGKQGTFHTEQAIEYGTKMVGGVNPKKAGTThlKHGLPVFATVKEAKKATGADASVIYVPPPHAASAI 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  83 LEALDSGIKTIVVTAEGIPLHEMLQLRK-LALEKEAMVIGGNTTGIISTGKAMMGFFPywlDRVYKPGRVGVMTRSGSLT 161
Cdd:PTZ00187  106 IEAIEAEIPLVVCITEGIPQHDMVKVKHaLLSQNKTRLIGPNCPGIIKPGECKIGIMP---GHIHKKGKIGIVSRSGTLT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 162 NEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLFTKPLIGFMGGR 241
Cdd:PTZ00187  183 YEAVAQTTAVGLGQSTCVGIGGDPFNGTNFIDCLKLFLNDPETEGIILIGEIGGTAEEEAAEWIKNNPIKKPVVSFIAGI 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1119888777 242 TAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIGPLLKQIL 292
Cdd:PTZ00187  263 TAPPGRRMGHAGAIISGGKGTAPGKIEALEAAGVRVVKSPAQLGKTMLEVM 313
PLN00125 PLN00125
Succinyl-CoA ligase [GDP-forming] subunit alpha
 2-285 2.71e-82

Succinyl-CoA ligase [GDP-forming] subunit alpha


Pssm-ID: 215066 [Multi-domain]  Cd Length: 300  Bit Score: 250.27  E-value: 2.71e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   2 SIIIDQNTPVLIQGITGKEGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:PLN00125    6 AVFVDKNTRVICQGITGKNGTFHTEQAIEYGTKMVGGVTPKKGGTEHLGLPVFNTVAEAKAETKANASVIYVPPPFAAAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  82 ILEALDSGIKTIVVTAEGIPLHEMLQLRK-LALEKEAMVIGGNTTGIISTGKAMMGFFPYWldrVYKPGRVGVMTRSGSL 160
Cdd:PLN00125   86 ILEAMEAELDLVVCITEGIPQHDMVRVKAaLNRQSKTRLIGPNCPGIIKPGECKIGIMPGY---IHKPGRIGIVSRSGTL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 161 TNEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLFTKPLIGFMGG 240
Cdd:PLN00125  163 TYEAVFQTTAVGLGQSTCVGIGGDPFNGTNFVDCLEKFVKDPQTEGIILIGEIGGTAEEDAAAFIKESGTEKPVVAFIAG 242

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1119888777 241 RTAPKGQKMGHAGAIITAGKGTVADKVGALTRAGALVADRPSMIG 285
Cdd:PLN00125  243 LTAPPGRRMGHAGAIVSGGKGTAQDKIKALREAGVTVVESPAKIG 287
PLN02522 PLN02522
ATP citrate (pro-S)-lyase
 36-277 1.37e-27

ATP citrate (pro-S)-lyase


Pssm-ID: 178137 [Multi-domain]  Cd Length: 608  Bit Score: 111.84  E-value: 1.37e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  36 VAG-VTPGKE-------GQDVDGIPVYHTVRRAVAEHHiEASLLV--VPPKAARGAILEALDSG-IKTIVVTAEGIPLHE 104
Cdd:PLN02522   40 VAGiINPGSEgfqklffGQEEIAIPVHGSIEAACKAHP-TADVFInfASFRSAAASSMEALKQPtIRVVAIIAEGVPESD 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 105 MLQLRKLALEKEAMVIGGNTTGIISTGKAMMGFFPYWLD-----RVYKPGRVGVMTRSGSLTNEITAEIVKAGFGPSSIV 179
Cdd:PLN02522  119 TKQLIAYARANNKVVIGPATVGGIQAGAFKIGDTAGTLDniiqcKLYRPGSVGFVSKSGGMSNEMYNVIARVTDGIYEGI 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 180 GVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAIEQGLFTKPLIGFMGGRTA---PKGQKMGHAGAII 256
Cdd:PLN02522  199 AIGGDVFPGSTLSDHVLRFNNIPQIKMIVVLGELGGRDEYSLVEALKQGKVSKPVVAWVSGTCArlfKSEVQFGHAGAKS 278

                         250       260
                  ....*....|....*....|.
gi 1119888777 257 TAGKGTVADKVGALTRAGALV 277
Cdd:PLN02522  279 GGDMESAQAKNKALKDAGAIV 299
CoA_binding smart00881
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 5-100 2.97e-23

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 214881 [Multi-domain]  Cd Length: 100  Bit Score: 91.42  E-value: 2.97e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777    5 IDQNTPVLIQGITGKEGSFWAKHAK---TYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGA 81
Cdd:smart00881   2 LNPNTSVAVVGASGNLGSFGLAVMRnllEYGTKFVGGVYPGKVGPKVDGVPVYDSVAEAPEETGVDVAVIFVPAEAAPDA 81

                           90
                   ....*....|....*....
gi 1119888777   82 ILEALDSGIKTIVVTAEGI 100
Cdd:smart00881  82 IDEAIEAGIKGIVVITEGI 100
CoA_binding pfam02629
CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins ...
 6-99 1.74e-22

CoA binding domain; This domain has a Rossmann fold and is found in a number of proteins including succinyl CoA synthetases, malate and ATP-citrate ligases.


Pssm-ID: 396961 [Multi-domain]  Cd Length: 97  Bit Score: 89.19  E-value: 1.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   6 DQNTPVLIQGITGK---EGSFWAKHAKTYGTNVVAGVTPGKEGQDVDGIPVYHTVRRAVAEHHIEASLLVVPPKAARGAI 82
Cdd:pfam02629   1 DKDTKVIVIGAGGLgiqGLNYHFIQMLGYGIKMVFGVNPGKGGTEILGIPVYNSVDELEEKTGVDVAVITVPAPFAQEAI 80

                          90
                  ....*....|....*..
gi 1119888777  83 LEALDSGIKTIVVTAEG 99
Cdd:pfam02629  81 DELVDAGIKGIVNITPG 97
Ligase_CoA pfam00549
CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, ...
 154-276 1.39e-15

CoA-ligase; This family includes the CoA ligases Succinyl-CoA synthetase alpha and beta chains, malate CoA ligase and ATP-citrate lyase. Some members of the family utilize ATP others use GTP.


Pssm-ID: 395434 [Multi-domain]  Cd Length: 128  Bit Score: 71.52  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 154 MTRSGSLTNEITAEIVKAGFGPSSIVGVGGDPVPFTRFAEILPLFEKDPDTDAVVMIGEIGGTMEEDVAEAI-----EQG 228
Cdd:pfam00549   1 LVNGGTLAMEAMDLIKLAGGGPHNFIDLGGDAFTPTTRIDALKLEAADPEVKVILLDIVLGYGACEDPAGGLlkaikEAR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1119888777 229 LFTKPLIGFMGGRTAPKGQKMGHAGAIITAGKGTVADKVGALTRAGAL 276
Cdd:pfam00549  81 ARELPVVARVCGTEADPQGRSGQAKALAESGVLIASSNNQALRAAGAV 128
Succ_CoA_lig pfam13607
Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from ...
 148-279 7.83e-08

Succinyl-CoA ligase like flavodoxin domain; This domain contains the catalytic domain from Succinyl-CoA ligase alpha subunit and other related enzymes. A conserved histidine is involved in phosphoryl transfer.


Pssm-ID: 433345 [Multi-domain]  Cd Length: 138  Bit Score: 50.54  E-value: 7.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 148 PGRVGVMTRSGSLTNEITAEIVKAGFGPSSIVGVGG--DpvpfTRFAEILPLFEKDPDTDAVVM----IGEIGGTMEedV 221
Cdd:pfam13607   1 PGNIALVSQSGALGAALLDWARSRGIGFSKFVSLGNeaD----VDFADLLEYLADDPETRVILLylegIRDGRRFLR--A 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777 222 AEAIEQglfTKPLIGFMGGRTaPKGQKMG--HAGAIitAGKGTVADkvGALTRAGALVAD 279
Cdd:pfam13607  75 ARRAAR---RKPVVVLKAGRS-EAGARAAasHTGAL--AGSDAVYD--AAFRQAGVIRVD 126
PRK05472 PRK05472
redox-sensing transcriptional repressor Rex; Provisional
 5-93 6.14e-05

redox-sensing transcriptional repressor Rex; Provisional


Pssm-ID: 235486 [Multi-domain]  Cd Length: 213  Bit Score: 43.18  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777   5 IDQNTPVLIQGItGKEGSFWAKHA--KTYGTNVVAG--VTPGKEGQDVDGIPVYHT--VRRAVAEHHIEASLLVVPPKAA 78
Cdd:PRK05472   81 LDRTWNVALVGA-GNLGRALLNYNgfEKRGFKIVAAfdVDPEKIGTKIGGIPVYHIdeLEEVVKENDIEIGILTVPAEAA 159

                          90
                  ....*....|....*
gi 1119888777  79 RGAILEALDSGIKTI 93
Cdd:PRK05472  160 QEVADRLVEAGIKGI 174
PRK06091 PRK06091
membrane protein FdrA; Validated
 70-183 2.94e-04

membrane protein FdrA; Validated


Pssm-ID: 180395 [Multi-domain]  Cd Length: 555  Bit Score: 41.95  E-value: 2.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1119888777  70 LLVVPPKAARGAILEALDSGiKTIVVTAEGIPLHEMLQLRKLALEKEAMVIGGNTtgiistGKAMMGFFPYWLDRVYKPG 149
Cdd:PRK06091  122 LISVAGEYAAELAEQALDRN-LNVMMFSDNVTLEDEIRLKTRAREKGLLVMGPDC------GTAMIAGTPLAFANVMPEG 194

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1119888777 150 RVGVMTRSGSLTNEITAEIVKAGFGPSSIVGVGG 183
Cdd:PRK06091  195 NIGVIGASGTGIQELCSQIALAGEGITHAIGLGG 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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