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Conserved domains on  [gi|1120097870|ref|WP_072968767|]
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DNA-directed RNA polymerase subunit beta [Caminicella sporogenes]

Protein Classification

DNA-directed RNA polymerase subunit beta( domain architecture ID 11478603)

DNA-directed RNA polymerase subunit beta catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1165 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


:

Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2255.75  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870    1 MPHPVKVGKGTRMSFSKIDKVLEMPNLIEIQKRSYKWFL-------EEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKP 73
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFVSYEL-GEP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   74 KYDQEECKERDVTYAVPLKVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKT- 152
Cdd:PRK00405    80 KYDVEECKERGLTYSAPLRVKLRLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKTs 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  153 -GKRLFSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFGE------------------- 212
Cdd:PRK00405   160 sGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEkeefgkeievpveyllgkv 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  213 --------------------------DERLLKTLEKDSVKSKEEGLIEVYKKLRPGEPPTVESASSLINSLFFDPKRYDL 266
Cdd:PRK00405   239 laedivdeetgevlaeandeiteeldGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  267 AKVGRYKFNKKLslvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvniygedekvvkvignnfvdik 346
Cdd:PRK00405   319 SKVGRYKLNKKL-------------------------------------------------------------------- 330
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  347 ahidfnidDLNITEKVhyptlkkiletytteedikealrekigelvpKHIIIDDIIATMSYILNLPHGVGRVDDIDHLGN 426
Cdd:PRK00405   331 --------GLDEDEDV-------------------------------RVLTKEDIIATIKYLINLRNGKGEVDDIDHLGN 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  427 RRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 506
Cdd:PRK00405   372 RRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  507 SALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVDKerGVVTDEIEYLTA 586
Cdd:PRK00405   452 SALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVD--GKVTDEIVYLTA 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  587 DEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQR 666
Cdd:PRK00405   530 DEEDNYVIAQANAPLDEDGRFVDELVTAR-YKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  667 QAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKR----HSDGGKDEYKLLKFKRSNQGTCINQKP 742
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVeeldPGEDGVDIYNLIKFQRSNQNTCINQRP 688
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  743 LVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEE 822
Cdd:PRK00405   689 IVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEE 768
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  823 ITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIV 902
Cdd:PRK00405   769 ITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVI 848
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  903 DVKVFTR-ENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMN 981
Cdd:PRK00405   849 DVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMN 928
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  982 IGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDK 1061
Cdd:PRK00405   929 IGQILETHLGWAAKGLGIKFATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDK 1008
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1062 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIVKGENIPEPGIPES 1141
Cdd:PRK00405  1009 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPES 1088
                         1210      1220
                   ....*....|....*....|....
gi 1120097870 1142 FKVLIKELQSLCLDVKVLSENADE 1165
Cdd:PRK00405  1089 FNVLVKELQSLGLDVELLDEDGNE 1112
PRK00566 super family cl35110
DNA-directed RNA polymerase subunit beta'; Provisional
279-327 1.11e-10

DNA-directed RNA polymerase subunit beta'; Provisional


The actual alignment was detected with superfamily member PRK00566:

Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 66.24  E-value: 1.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:PRK00566   801 PLEERILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKIEEAGIEEVKI 849
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1165 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2255.75  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870    1 MPHPVKVGKGTRMSFSKIDKVLEMPNLIEIQKRSYKWFL-------EEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKP 73
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFVSYEL-GEP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   74 KYDQEECKERDVTYAVPLKVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKT- 152
Cdd:PRK00405    80 KYDVEECKERGLTYSAPLRVKLRLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKTs 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  153 -GKRLFSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFGE------------------- 212
Cdd:PRK00405   160 sGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEkeefgkeievpveyllgkv 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  213 --------------------------DERLLKTLEKDSVKSKEEGLIEVYKKLRPGEPPTVESASSLINSLFFDPKRYDL 266
Cdd:PRK00405   239 laedivdeetgevlaeandeiteeldGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  267 AKVGRYKFNKKLslvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvniygedekvvkvignnfvdik 346
Cdd:PRK00405   319 SKVGRYKLNKKL-------------------------------------------------------------------- 330
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  347 ahidfnidDLNITEKVhyptlkkiletytteedikealrekigelvpKHIIIDDIIATMSYILNLPHGVGRVDDIDHLGN 426
Cdd:PRK00405   331 --------GLDEDEDV-------------------------------RVLTKEDIIATIKYLINLRNGKGEVDDIDHLGN 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  427 RRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 506
Cdd:PRK00405   372 RRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  507 SALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVDKerGVVTDEIEYLTA 586
Cdd:PRK00405   452 SALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVD--GKVTDEIVYLTA 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  587 DEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQR 666
Cdd:PRK00405   530 DEEDNYVIAQANAPLDEDGRFVDELVTAR-YKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  667 QAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKR----HSDGGKDEYKLLKFKRSNQGTCINQKP 742
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVeeldPGEDGVDIYNLIKFQRSNQNTCINQRP 688
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  743 LVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEE 822
Cdd:PRK00405   689 IVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEE 768
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  823 ITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIV 902
Cdd:PRK00405   769 ITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVI 848
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  903 DVKVFTR-ENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMN 981
Cdd:PRK00405   849 DVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMN 928
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  982 IGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDK 1061
Cdd:PRK00405   929 IGQILETHLGWAAKGLGIKFATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDK 1008
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1062 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIVKGENIPEPGIPES 1141
Cdd:PRK00405  1009 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPES 1088
                         1210      1220
                   ....*....|....*....|....
gi 1120097870 1142 FKVLIKELQSLCLDVKVLSENADE 1165
Cdd:PRK00405  1089 FNVLVKELQSLGLDVELLDEDGNE 1112
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1162 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 2018.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   12 RMSFSKIDKVLEMPNLIEIQKRSYKWFLEEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKPKYDQEECKERDVTYAVPL 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEFGDYRL-GEPKYTPEECKERDLTYAAPL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   92 KVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKTGKRLFSTTVIPNRGAWLEY 171
Cdd:COG0085     80 YVKVRLVNKETGEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEF 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  172 ETDSNQIISVRIDRTRKLPFTVFVRALGYGTDQEIINLFGED---ERLLKTLEKDSVKSKEEGLIEVYKKLRPGEPPTVE 248
Cdd:COG0085    160 ETDKDGTIYVRIDRKRKIPVTVLLRALGLETDEEILEAFGDDpiqEYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  249 SASSLINSLFFDPKRYDLAKVGRYKFNKKLSLvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvnIY 328
Cdd:COG0085    240 RAEQLLDNLFFDPKRYDLAHVGRYKINKKLGL----------------------------------------------DV 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  329 GEDEKVVKVignnfvdikahidfniddlnitekvhyptlkkiletytteedikealrekigelvpkhiiiDDIIATMSYI 408
Cdd:COG0085    274 PPEDRVLTA-------------------------------------------------------------EDIVATIKYL 292
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  409 LNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLS 488
Cdd:COG0085    293 LELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLS 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  489 QFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYR 568
Cdd:COG0085    373 QFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYR 452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  569 KVdkERGVVTDEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVSPQQIVSVATAMIP 648
Cdd:COG0085    453 KV--ENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVR-YRGEEVLVPPEEVDYMDVSPKQIVSVATSLIP 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  649 FLENDDANRALMGSNMQRQAVPLIKTESPIigtgmeyiaakdsgtvvvakndgivervtadkiivkrhsdggkDEYKLLK 728
Cdd:COG0085    530 FLEHDDANRALMGANMQRQAVPLLRPEAPL-------------------------------------------LHYPLQK 566
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  729 FKRSNQGTCINQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEE 808
Cdd:COG0085    567 FQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEE 646
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  809 YEAEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRD 888
Cdd:COG0085    647 YEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRD 726
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  889 TSLKVPHGESGIIVDVKVFTRENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQ 968
Cdd:COG0085    727 TSLRVPHGEKGKVIDVKVFSREEGDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVD 806
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  969 VVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGY 1048
Cdd:COG0085    807 IVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGY 886
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1049 MYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIV 1128
Cdd:COG0085    887 MYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIV 966
                         1130      1140      1150
                   ....*....|....*....|....*....|....
gi 1120097870 1129 KGENIPEPGIPESFKVLIKELQSLCLDVKVLSEN 1162
Cdd:COG0085    967 KGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
12-1158 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1918.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   12 RMSFSKIDKVLEMPNLIEIQKRSYKWFL----------EEGLMEAFNDISPIQDYTGNLILEFVDYSLDgKPKYDQEECK 81
Cdd:TIGR02013    5 RIDFGKIPEVLEVPNLLEIQLDSYDWFLqqdtppekrkEEGLEEVFKSIFPIEDYTGNIELEYLSYRLG-EPKYSVEECK 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   82 ERDVTYAVPLKVKVRFINKE---TGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQID--KTGKRL 156
Cdd:TIGR02013   84 ERGLTYSAPLKVKLRLINKEedgTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKDttKSGKVL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  157 FSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYGTDQEIINLFGEDERLLKTLEKDSVKSKEEGLIEVY 236
Cdd:TIGR02013  164 FSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIY 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  237 KKLRPGEPPTVESASSLINSLFFDPKRYDLAKVGRYKFNKKLSLvdrivgfvaaenvvdentgeilvqegqkidketaqk 316
Cdd:TIGR02013  244 RKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGL------------------------------------ 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  317 iensgvksvniygedekvvkvignnfvdikahidfniddlnitekvHYPTLKKILETytteedikealrekigelvpkhi 396
Cdd:TIGR02013  288 ----------------------------------------------DVPESIGVLTK----------------------- 298
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  397 iiDDIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVA 476
Cdd:TIGR02013  299 --EDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISA 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  477 AIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYAR 556
Cdd:TIGR02013  377 AIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYAR 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  557 INEYGFIEAPYRKVDKERGVVTDEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARLRGgDIDVVPSSEVDYVDVSP 636
Cdd:TIGR02013  457 VNEYGFIETPYRKVKDGKVVVTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYRG-EITLVSPDQVDYMDVSP 535
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  637 QQIVSVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKRH 716
Cdd:TIGR02013  536 KQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYD 615
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  717 S-----DGGKDEYKLLKFKRSNQGTCINQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILL 791
Cdd:TIGR02013  616 EdeeepDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILI 695
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  792 SEELVMNDVLTSIHIEEYEAEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAE 871
Cdd:TIGR02013  696 SERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPE 775
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  872 ERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISR 951
Cdd:TIGR02013  776 EKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSK 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  952 ILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWK---VATPVFDGAKETDIAELLEECGYPVDGK 1028
Cdd:TIGR02013  856 ILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRKgvpIATPVFDGASEEEIKEYLEKAGLPRDGK 935
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1029 LQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQE 1108
Cdd:TIGR02013  936 VRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQE 1015
                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1109 ILTVKSDDVVGRVKTYEAIVKGENIPEPGIPESFKVLIKELQSLCLDVKV 1158
Cdd:TIGR02013 1016 MLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1158 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 989.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   27 LIEIQKRSYKWFLEEGLMEAFNDISPIQDYT--GNLILEFVDYSLdGKP---------KYDQEECKERDVTYAVPLKVKV 95
Cdd:cd00653      1 LVKQQIDSFNYFLNVGLQEIVKSIPPITDTDddGRLKLKFGDIYL-GKPkveeggvtrKLTPNECRLRDLTYSAPLYVDI 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   96 RFINKETGEVKEQEVFMGDFPLMTE------------------------KGTFIINGAERVIVSQLVRSPGPYYsvQIDK 151
Cdd:cd00653     80 RLTVNDKGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQRSPNVII--VEDS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  152 TGKRLFSTTVIPN----RGAWLEYETDS-NQIISVRIDRTRKlpftvfvralgygtdqeiinlfgederllktlekdsvk 226
Cdd:cd00653    158 KGKRIYTKTSIPSyspyRGSWLEVKSDKkKDRIYVRIDLKRQ-------------------------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  227 skEEGLIEVYKKLRpgepptvesasslinslffdpkrydlakvgrykfnkklslvdrivgfvaaenvvdentgeilvqeg 306
Cdd:cd00653    200 --EEALKYIGKRFE------------------------------------------------------------------ 211
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  307 qkidketaqkiensgvksvniygedekvvkvignnfvdikahidfniddlnitekvhyptlkkiletytteedikealre 386
Cdd:cd00653        --------------------------------------------------------------------------------
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  387 kigelvpkhiiidDIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDM--DTIT 464
Cdd:cd00653    212 -------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSkkKDLT 278
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  465 PQALINIRPVVAAIKEFFGSSQ------------LSQFMDQTNPLSELTHKRRLSAlgpGGLSRERAGFEVRDVHHSHYG 532
Cdd:cd00653    279 PQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWG 355
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  533 RMCPIETPEGPNIGLINSLSTYARINeyGFIEAPYRKVDKErgvvtdeieyltadeeekyvfaqanepldeegrfinkrv 612
Cdd:cd00653    356 RICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEKE--------------------------------------- 394
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  613 varlrggdidvvpsseVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESPIIGTGMEYIaakdsg 692
Cdd:cd00653    395 ----------------VTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYL------ 452
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  693 tvvvakndgivervtadkiivkrhsdggkdeykLLKfkrsnqgtciNQKPLVDNGDEvkagEIIAdgpstdNGEIALGKN 772
Cdd:cd00653    453 ---------------------------------LLY----------PQKPLVGTGIE----EYIA------FGELPLGQN 479
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  773 LLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEEITR-DIPNVGEDALKNLDERGIIRIGAEVT 851
Cdd:cd00653    480 AIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVE 559
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  852 SGDILVGKVTPKGETELTAeerllraIFGEKAREVRDTSLKVPHGESGIIVDVKVFTREngdeLPPGVNVLVRVYIAKKR 931
Cdd:cd00653    560 PGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRE----LNDGGNKLVKVYIRQKR 628
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  932 KISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDGAKE 1011
Cdd:cd00653    629 KPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEE 708
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1012 TDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGE 1091
Cdd:cd00653    709 EDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGE 788
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1120097870 1092 MEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIV----------KGENIPEPGIPESFKVLIKELQSLCLDVKV 1158
Cdd:cd00653    789 MERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRL 865
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
696-1083 0e+00

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 564.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  696 VAKNDGIVERVTADKIIVKrhSDGGKDE---YKLLKFKRSNQGT---CINQKPLVDNGDeVKAGeiiadgpstDNGEIAL 769
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQ--CAMGKQAmgiYTLNKFYRSDQNTyvlCYPQKPLVKTGA-VEAG---------GFGELPL 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  770 GKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAeaRDTKLGP-EEITRDIPNVGEDALKNLDERGIIRIGA 848
Cdd:pfam00562   69 GQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKEIEA--RKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRVGA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  849 EVTSGDILVGKVtpkGETELTaeeRLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTrengdeLPPGVNVLVRVYIA 928
Cdd:pfam00562  147 EVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------LPPGGIKMVKVYIR 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  929 KKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDG 1008
Cdd:pfam00562  215 QKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDG 294
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1120097870 1009 AKET--DIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQ 1083
Cdd:pfam00562  295 ASTEveDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
279-327 1.11e-10

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 66.24  E-value: 1.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:PRK00566   801 PLEERILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKIEEAGIEEVKI 849
RpoC COG0086
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ...
279-327 1.47e-05

DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439856 [Multi-domain]  Cd Length: 1165  Bit Score: 49.39  E-value: 1.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:COG0086    800 PLKERILGRVAAEDVVDPGTGEVLVPAGTLIDEEVAEIIEEAGIDSVKV 848
 
Name Accession Description Interval E-value
rpoB PRK00405
DNA-directed RNA polymerase subunit beta; Reviewed
1-1165 0e+00

DNA-directed RNA polymerase subunit beta; Reviewed


Pssm-ID: 234749 [Multi-domain]  Cd Length: 1112  Bit Score: 2255.75  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870    1 MPHPVKVGKGTRMSFSKIDKVLEMPNLIEIQKRSYKWFL-------EEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKP 73
Cdd:PRK00405     1 MVYSYTGKKRIRKSFGKIKEVLELPNLLEIQLDSFDWFLqldvppeDEGLEEVFRSIFPIEDFNGNLSLEFVSYEL-GEP 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   74 KYDQEECKERDVTYAVPLKVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKT- 152
Cdd:PRK00405    80 KYDVEECKERGLTYSAPLRVKLRLINKETGEIKEQEVYMGDIPLMTENGTFIINGTERVIVSQLHRSPGVYFDHDKDKTs 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  153 -GKRLFSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFGE------------------- 212
Cdd:PRK00405   160 sGKLLYSARIIPYRGSWLEFEFDPKDILYVRIDRRRKLPVTVLLRALGY-SDEEILDLFYEkeefgkeievpveyllgkv 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  213 --------------------------DERLLKTLEKDSVKSKEEGLIEVYKKLRPGEPPTVESASSLINSLFFDPKRYDL 266
Cdd:PRK00405   239 laedivdeetgevlaeandeiteeldGPYIRNTLEKDPTSSREEALVEIYRRLRPGEPPTVEAARSLLENLFFDPKRYDL 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  267 AKVGRYKFNKKLslvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvniygedekvvkvignnfvdik 346
Cdd:PRK00405   319 SKVGRYKLNKKL-------------------------------------------------------------------- 330
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  347 ahidfnidDLNITEKVhyptlkkiletytteedikealrekigelvpKHIIIDDIIATMSYILNLPHGVGRVDDIDHLGN 426
Cdd:PRK00405   331 --------GLDEDEDV-------------------------------RVLTKEDIIATIKYLINLRNGKGEVDDIDHLGN 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  427 RRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 506
Cdd:PRK00405   372 RRVRSVGELLQNQFRIGLSRMERAVRERMSLQDLDTLTPQDLINAKPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRL 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  507 SALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVDKerGVVTDEIEYLTA 586
Cdd:PRK00405   452 SALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLATYARVNEYGFIETPYRKVVD--GKVTDEIVYLTA 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  587 DEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQR 666
Cdd:PRK00405   530 DEEDNYVIAQANAPLDEDGRFVDELVTAR-YKGEFVLVPPEEVDYMDVSPKQVVSVAASLIPFLEHDDANRALMGSNMQR 608
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  667 QAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKR----HSDGGKDEYKLLKFKRSNQGTCINQKP 742
Cdd:PRK00405   609 QAVPLLRPEAPLVGTGMERRVARDSGAVVVAKRDGVVEYVDASRIVVRVeeldPGEDGVDIYNLIKFQRSNQNTCINQRP 688
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  743 LVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEE 822
Cdd:PRK00405   689 IVKVGDRVEKGDVLADGPSTDNGELALGQNVLVAFMPWNGYNFEDAILISERLVKEDVFTSIHIEEYEIEARDTKLGPEE 768
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  823 ITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIV 902
Cdd:PRK00405   769 ITRDIPNVSEEALRNLDESGIVRIGAEVKPGDILVGKVTPKGETELTPEEKLLRAIFGEKARDVKDTSLRVPHGEEGTVI 848
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  903 DVKVFTR-ENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMN 981
Cdd:PRK00405   849 DVKVFTRiEQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSRILPVEDMPYLEDGTPVDIVLNPLGVPSRMN 928
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  982 IGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDK 1061
Cdd:PRK00405   929 IGQILETHLGWAAKGLGIKFATPVFDGAKEEEIKELLEEAGLPEDGKTTLYDGRTGEPFDRPVTVGYMYMLKLHHLVDDK 1008
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1062 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIVKGENIPEPGIPES 1141
Cdd:PRK00405  1009 IHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQEMLTVKSDDVVGRTKVYEAIVKGENIPEPGIPES 1088
                         1210      1220
                   ....*....|....*....|....
gi 1120097870 1142 FKVLIKELQSLCLDVKVLSENADE 1165
Cdd:PRK00405  1089 FNVLVKELQSLGLDVELLDEDGNE 1112
RpoB COG0085
DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA ...
12-1162 0e+00

DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; DNA-directed RNA polymerase, beta subunit/140 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439855 [Multi-domain]  Cd Length: 1001  Bit Score: 2018.86  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   12 RMSFSKIDKVLEMPNLIEIQKRSYKWFLEEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKPKYDQEECKERDVTYAVPL 91
Cdd:COG0085      1 RWSFAKIKEPLELPNLLEIQLDSFNWFLEEGLQEIFDEISPIEDFTGNLSLEFGDYRL-GEPKYTPEECKERDLTYAAPL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   92 KVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKTGKRLFSTTVIPNRGAWLEY 171
Cdd:COG0085     80 YVKVRLVNKETGEIKEQEVFMGDFPLMTDSGTFIINGTERVIVSQLVRSPGVYFVEEEDKSGKDLYSAKVIPSRGAWLEF 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  172 ETDSNQIISVRIDRTRKLPFTVFVRALGYGTDQEIINLFGED---ERLLKTLEKDSVKSKEEGLIEVYKKLRPGEPPTVE 248
Cdd:COG0085    160 ETDKDGTIYVRIDRKRKIPVTVLLRALGLETDEEILEAFGDDpiqEYILATLEKDNTKTQEEALLEIYRKLRPGEPPTIE 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  249 SASSLINSLFFDPKRYDLAKVGRYKFNKKLSLvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvnIY 328
Cdd:COG0085    240 RAEQLLDNLFFDPKRYDLAHVGRYKINKKLGL----------------------------------------------DV 273
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  329 GEDEKVVKVignnfvdikahidfniddlnitekvhyptlkkiletytteedikealrekigelvpkhiiiDDIIATMSYI 408
Cdd:COG0085    274 PPEDRVLTA-------------------------------------------------------------EDIVATIKYL 292
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  409 LNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLS 488
Cdd:COG0085    293 LELHLGEREPDDIDHLGNRRVRLVGELLQNQFRVGLSRMERVVRERMTTQDVEAITPQSLINIRPVVAAIKEFFGSSQLS 372
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  489 QFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYR 568
Cdd:COG0085    373 QFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHPSHYGRMCPIETPEGPNIGLIGSLALYARVNEYGFIETPYR 452
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  569 KVdkERGVVTDEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVSPQQIVSVATAMIP 648
Cdd:COG0085    453 KV--ENGKVTDEIEYLTADEEENYYIAQANAPLDEDGNFLEERVLVR-YRGEEVLVPPEEVDYMDVSPKQIVSVATSLIP 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  649 FLENDDANRALMGSNMQRQAVPLIKTESPIigtgmeyiaakdsgtvvvakndgivervtadkiivkrhsdggkDEYKLLK 728
Cdd:COG0085    530 FLEHDDANRALMGANMQRQAVPLLRPEAPL-------------------------------------------LHYPLQK 566
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  729 FKRSNQGTCINQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEE 808
Cdd:COG0085    567 FQRSNQGTCINQRPIVRVGDRVEKGDVLADGPATDNGELALGQNLLVAFMPWEGYNYEDAIIISERLVKDDVLTSIHIEE 646
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  809 YEAEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRD 888
Cdd:COG0085    647 YEIEARDTKLGPEEITRDIPNVSEEALRNLDEDGIIRIGAEVKGGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRD 726
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  889 TSLKVPHGESGIIVDVKVFTRENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQ 968
Cdd:COG0085    727 TSLRVPHGEKGKVIDVKVFSREEGDELPPGVNKLVRVYVAQKRKIEVGDKLAGRHGNKGVISRILPQEDMPFLEDGTPVD 806
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  969 VVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGY 1048
Cdd:COG0085    807 IVLNPLGVPSRMNVGQVLETHLGWAAALLGRRVATPVFDGAPEEEIRELLEKAGLPPDGKEVLYDGRTGEPFDNPVTVGY 886
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1049 MYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIV 1128
Cdd:COG0085    887 MYYLKLHHMVDDKIHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQERLTIKSDDVCGRVKVYEAIV 966
                         1130      1140      1150
                   ....*....|....*....|....*....|....
gi 1120097870 1129 KGENIPEPGIPESFKVLIKELQSLCLDVKVLSEN 1162
Cdd:COG0085    967 KGENIPEPGIPESFKVLLKELQSLGLDVEVLSED 1000
rpoB TIGR02013
DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit ...
12-1158 0e+00

DNA-directed RNA polymerase, beta subunit; This model describes orthologs of the beta subunit of Bacterial RNA polymerase. The core enzyme consists of two alpha chains, one beta chain, and one beta' subunit. [Transcription, DNA-dependent RNA polymerase]


Pssm-ID: 273928 [Multi-domain]  Cd Length: 1065  Bit Score: 1918.26  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   12 RMSFSKIDKVLEMPNLIEIQKRSYKWFL----------EEGLMEAFNDISPIQDYTGNLILEFVDYSLDgKPKYDQEECK 81
Cdd:TIGR02013    5 RIDFGKIPEVLEVPNLLEIQLDSYDWFLqqdtppekrkEEGLEEVFKSIFPIEDYTGNIELEYLSYRLG-EPKYSVEECK 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   82 ERDVTYAVPLKVKVRFINKE---TGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQID--KTGKRL 156
Cdd:TIGR02013   84 ERGLTYSAPLKVKLRLINKEedgTKEIKEQDVYMGDIPLMTDRGTFIINGAERVVVSQLHRSPGVFFSSEKDttKSGKVL 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  157 FSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYGTDQEIINLFGEDERLLKTLEKDSVKSKEEGLIEVY 236
Cdd:TIGR02013  164 FSARIIPYRGSWLEFETDKKDVLYVRIDRKRKLPATVLLRALGYTIDTLILNRLGSGEYIRNTLRKDPTNSEEEALVEIY 243
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  237 KKLRPGEPPTVESASSLINSLFFDPKRYDLAKVGRYKFNKKLSLvdrivgfvaaenvvdentgeilvqegqkidketaqk 316
Cdd:TIGR02013  244 RKLRPGEPPTVEAARSLLENLFFDPKRYDLGRVGRYKLNKKLGL------------------------------------ 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  317 iensgvksvniygedekvvkvignnfvdikahidfniddlnitekvHYPTLKKILETytteedikealrekigelvpkhi 396
Cdd:TIGR02013  288 ----------------------------------------------DVPESIGVLTK----------------------- 298
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  397 iiDDIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVA 476
Cdd:TIGR02013  299 --EDIIATIKYLIKLRNGKGEIDDIDHLGNRRIRSVGELLQNQFRVGLARMERIVRERMSTQDTDTLTPQDLINAKPISA 376
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  477 AIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYAR 556
Cdd:TIGR02013  377 AIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGFEVRDVHPTHYGRICPIETPEGPNIGLINSLSTYAR 456
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  557 INEYGFIEAPYRKVDKERGVVTDEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARLRGgDIDVVPSSEVDYVDVSP 636
Cdd:TIGR02013  457 VNEYGFIETPYRKVKDGKVVVTDEIDYLTADEEDNYVIAQANAPLDENGRFVEDLVVARYRG-EITLVSPDQVDYMDVSP 535
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  637 QQIVSVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKRH 716
Cdd:TIGR02013  536 KQVVSVAASLIPFLEHDDANRALMGSNMQRQAVPLLRSEAPLVGTGMEAKVARDSGAVIVAKRGGVVEYVDAKRIVIRYD 615
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  717 S-----DGGKDEYKLLKFKRSNQGTCINQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILL 791
Cdd:TIGR02013  616 EdeeepDGGIDIYRLLKYQRSNQDTCINQRPIVSVGDRVEAGDVLADGPSTDLGELALGRNVLVAFMPWNGYNYEDAILI 695
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  792 SEELVMNDVLTSIHIEEYEAEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAE 871
Cdd:TIGR02013  696 SERLVKDDVFTSIHIEEYEVEARDTKLGPEEITRDIPNVSEEALRNLDENGIVRIGAEVKAGDILVGKVTPKGETELTPE 775
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  872 ERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISR 951
Cdd:TIGR02013  776 EKLLRAIFGEKARDVRDTSLRVPPGVEGTVIDVKVFSREQGDELPPGVNKLVKVYIAQKRKIQVGDKMAGRHGNKGVVSK 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  952 ILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWK---VATPVFDGAKETDIAELLEECGYPVDGK 1028
Cdd:TIGR02013  856 ILPIEDMPFLEDGTPVDIVLNPLGVPSRMNIGQILETHLGWAGKRLGRKgvpIATPVFDGASEEEIKEYLEKAGLPRDGK 935
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1029 LQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQE 1108
Cdd:TIGR02013  936 VRLYDGRTGEQFDRPVTVGYMYMLKLHHLVDDKMHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTLQE 1015
                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1109 ILTVKSDDVVGRVKTYEAIVKGENIPEPGIPESFKVLIKELQSLCLDVKV 1158
Cdd:TIGR02013 1016 MLTVKSDDVVGRTKAYEAIVKGENVPEPGIPESFNVLIKELQSLGLDIEL 1065
rpoB CHL00207
RNA polymerase beta subunit; Provisional
24-1168 0e+00

RNA polymerase beta subunit; Provisional


Pssm-ID: 214397 [Multi-domain]  Cd Length: 1077  Bit Score: 1241.51  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   24 MPNLIEIQKRSYKWFLEEGLMEAFNDISPIQDYTGNLILEFV--DYSLDgKPKYDQEECKERDVTYAVPLKVKVRFINKE 101
Cdd:CHL00207     7 LPDFLEIQRTSFCWFLNEGLNEELNIFSKIFDYTGNLELLLFgkNYKLK-YPKYNLLSAKSYDSNYSIQIYLPLKFINLK 85
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  102 TGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKTGKRLFSTTVIPNRGAWLEYETDSNQIISV 181
Cdd:CHL00207    86 TNKIKFINYLIGNLPKMTQRGTFIINGLERVIVSQIIRSPGIYFKKEIKKNSNKIYSATLIPNRGSWIKFELDKNKEIWI 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  182 RIDRTRKLPFTVFVRALGYgTDQEI-INLFGEDERLLKT--LEKDSVKSKEEGLIEVYKKLRPGEPPTVESASSLINSLF 258
Cdd:CHL00207   166 RIDKNRKKPLIIFLKALGL-TDQDIySRLTKSEFLKKLKpiLLNSNSYTNEEILLEIYKNLSPIEPATVNDANQNLFSRF 244
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  259 FDPKRYDLAKVGRYKFNKKLslvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksvniygedekvvkvi 338
Cdd:CHL00207   245 FDPKNYDLGKVGRYKINNKL------------------------------------------------------------ 264
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  339 gnnfvdikahidfnidDLNITEKVhyptlkkiletytteedikealrekigelvpKHIIIDDIIATMSYILNLPHGVGRV 418
Cdd:CHL00207   265 ----------------NLNIPERV-------------------------------RNLTYEDILSIIDKLINLKINKGNF 297
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  419 DDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLS 498
Cdd:CHL00207   298 DDIDHLKNRRVRSVGELLQNQFRIGLKRLERILRNRMTICDIDSLSKFNLINPKPLIALIREFFGSSQLSQYMDQTNPLS 377
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  499 ELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVDKERGVVT 578
Cdd:CHL00207   378 ELTHKRRISILGPGGLDKDRISFAVRDIHPSHYGRICPIETPEGPNCGLIGSLATNARINKFGFIETPFYKVINGKVKKF 457
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  579 DEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARLRGgDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRA 658
Cdd:CHL00207   458 GNPIYLTADSEDLYRIAPNDINLNKNNYFKKNIIPVRYKQ-EFKTVNPSKVDFIAISPIQVFSIAESLIPFLEHNDANRA 536
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  659 LMGSNMQRQAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKrHSDGGKDEYKLLKFKRSNQGTCI 738
Cdd:CHL00207   537 LMGSNMQRQAVPLLYPEKPIVGTGYEKQIALDSGMTIISLTEGIVVSVSAYKIIIQ-DDNNRYIHYYLQKYQRSNQNTCI 615
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  739 NQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKL 818
Cdd:CHL00207   616 NYRPIVWVGEKINIGQILADGSDIDNSELALGQNVLVAYMPWEGYNFEDAILINKRLVYEDLFTSIHIEKYEIELRQTKL 695
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  819 GPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGES 898
Cdd:CHL00207   696 GSEEITRNIPNVSEYSLKNLDENGIISIGSKVLAGDILVGKITPKGESDQLPEGKLLRAIFGEKAKDVKDTSLRMPNGGY 775
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  899 GIIVDVKVFTRENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPS 978
Cdd:CHL00207   776 GRVIKVEIFSRSKGDELKFGYYLKIRVFIAQIRKIQVGDKLAGRHGNKGIISRILPRQDMPYLPDGTPPDIILNPLGVPS 855
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  979 RMNIGQVLEVHLGLAAKKLGWKVATPVFD-----GAKETDIAELLEECGYPVD----------GKLQLYDGRTGEPFDNR 1043
Cdd:CHL00207   856 RMNVGQLFECLLGLAGDNLNKRFKILPFDemygsEYSRILINNKLNQASIKNNeywlfnsyhpGKMVLRDGRTGYKFKNP 935
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1044 VTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKT 1123
Cdd:CHL00207   936 VTVGIAYMLKLIHLVDDKIHARTTGPYSLVTQQPLGGKAQHGGQRFGEMEVWALEAFGAAYTLKELLTIKSDDMQGRNET 1015
                         1130      1140      1150      1160      1170
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1120097870 1124 YEAIVKGENIPEPGIPESFKVLIKELQSLCLDVKV------LSENADEIEI 1168
Cdd:CHL00207  1016 LNAIVKGQPIPKPGTPESFKVLMRELQSLGLDIEAykienfLEGQRLEIEI 1066
rpoB CHL00001
RNA polymerase beta subunit
13-1170 0e+00

RNA polymerase beta subunit


Pssm-ID: 214330 [Multi-domain]  Cd Length: 1070  Bit Score: 1216.67  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   13 MSFSKIDKVLEMPNLIEIQKRSYKWFLEEGLMEAFNDISPIQDYTGNLILEFV--DYSLDgKPKYDQEECKERDVTYAVP 90
Cdd:CHL00001     1 MLRDGNEGMSTIPGFNQIQFEGFCRFIDQGLTEELSKFPKIEDTDQEIEFQLFveTYQLV-EPLIKERDAVYESLTYSSE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   91 LKVKVRFINKETGEVKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPYYSVQIDKTGKRLFSTTVIPNRGAWLE 170
Cdd:CHL00001    80 LYVPAGLIWKKSRDMQEQTVFIGNIPLMNSLGTFIINGIYRVVINQILRSPGIYYRSELDHNGISVYTGTIISDWGGRLE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  171 YETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFGEDERLLKTL---EKDSVKSKEEGLIEVYKKL--RPGEPP 245
Cdd:CHL00001   160 LEIDRKARIWARVSRKQKISILVLLSAMGL-NLREILDNVCYPEIFLSFLndkEKKKIGSKENAILEFYQQFacVGGDPV 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  246 TVESASSLINSLFFDpKRYDLAKVGRYKFNKKLSLvdrivgfvaaenvvdentgeilvqegqkidketaqkiensgvksv 325
Cdd:CHL00001   239 FSESLCKELQKKFFQ-QRCELGRIGRRNMNRKLNL--------------------------------------------- 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  326 niygedekvvkvignnfvDIKAHIDFniddlnitekvhyptlkkiletytteedikealrekigeLVPKhiiidDIIATM 405
Cdd:CHL00001   273 ------------------DIPENNTF---------------------------------------LLPQ-----DVLAAA 290
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  406 SYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERM--TIQDMDTITPQALINIRPVVAAIKEFFG 483
Cdd:CHL00001   291 DYLIGMKFGMGTLDDIDHLKNKRIRSVADLLQDQFGLALNRLENAVRGTIcgAIRRKLIPTPQNLVTSTPLTTTYESFFG 370
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  484 SSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFI 563
Cdd:CHL00001   371 SHPLSQFLDQTNPLTEIVHGRKLSSLGPGGLTGRTASFRVRDIHPSHYGRICPIDTSEGINAGLIGSLAIHARIGHWGSL 450
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  564 EAPYRKV---DKERGVVtdeieYLTADEEEKYVFAQANEPLDEEGRFINKRVVARLRGgDIDVVPSSEVDYVDVSPQQIV 640
Cdd:CHL00001   451 ESPFYEIserSKEERMV-----YLSPSEDEYYMIAAGNSLALNQGIQEEQVVPARYRQ-EFLTIAWEQIHLRSIFPFQYF 524
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  641 SVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKrhSDGG 720
Cdd:CHL00001   525 SIGASLIPFLEHNDANRALMGSNMQRQAVPLSRSEKCIVGTGLERQVALDSGVVAIAEHEGKIIYTDTDKIILS--GNGD 602
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  721 KDEYKLLKFKRSNQGTCINQKPLVDNGDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDV 800
Cdd:CHL00001   603 TLSIPLVMYQRSNKNTCMHQKPQVRRGKCVKKGQILADGAATVGGELALGKNVLVAYMPWEGYNFEDAVLISERLVYEDI 682
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  801 LTSIHIEEYEAEARDTKLGPEEITRDIPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPK--GETELTAEERLLRAI 878
Cdd:CHL00001   683 YTSFHIRKYEIQTHVTSQGPERITKEIPHLEAHLLRNLDKNGIVMLGSWVETGDILVGKLTPQeaEESSYAPEGRLLRAI 762
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  879 FGEKAREVRDTSLKVPHGESGIIVDVKVFTRENGDELPPGVnvlVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDM 958
Cdd:CHL00001   763 FGIQVSTSKETCLKLPIGGRGRVIDVRWIQKKGGSSYNPET---IHVYILQKREIQVGDKVAGRHGNKGIISKILPRQDM 839
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  959 PFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLG--WKVaTPvFDGAKETD------IAELLE----------- 1019
Cdd:CHL00001   840 PYLQDGTPVDMVLNPLGVPSRMNVGQIFECLLGLAGDLLNrhYRI-AP-FDERYEQEasrklvFSELYEaskqtanpwvf 917
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1020 ECGYPvdGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEA 1099
Cdd:CHL00001   918 EPEYP--GKSRLFDGRTGDPFEQPVTIGKAYILKLIHQVDDKIHARSSGPYALVTQQPLRGRSKQGGQRVGEMEVWALEG 995
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1120097870 1100 YGAAHTLQEILTVKSDDVVGRVKTYEAIVKGENIPEP-GIPESFKVLIKELQSLCLDVK--VLSENADEIEIKE 1170
Cdd:CHL00001   996 FGVAYILQEMLTYKSDHIRARQEVLGAIITGGTIPKPeDAPESFRLLVRELRSLALELNhfLVSEKNFQINRKE 1069
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
1-1172 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 1128.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870    1 MPHPVKVGKGTRMSFSKIDKVLEMPNLIEIQKRSYKWFL------EEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKPK 74
Cdd:PRK09603     1 MSKKIPLKNRLRADFTKTPTDLEVPNLLLLQRDSYDSFLyskdgkESGIEKVFKSIFPIQDEHNRITLEYAGCEF-GKSK 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   75 YDQEECKERDVTYAVPLKVKVRFI----NKETGE------VKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPGPY 144
Cdd:PRK09603    80 YTVREAMERGITYSIPLKIKVRLIlwekDTKSGEkngikdIKEQSIFIREIPLMTERTSFIINGVERVVVNQLHRSPGVI 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  145 YSVQIDKT--GKRLFSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFgedERLLKtlek 222
Cdd:PRK09603   160 FKEEESSTslNKLIYTGQIIPDRGSWLYFEYDSKDVLYARINKRRKVPVTILFRAMDY-QKQDIIKMF---YPLVK---- 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  223 dsVKSKEEGLIEVYKKLRPGEPPTVESASSLINSLFFDPKRYDLAKVGRYKfNKKLSLV----DRIVGFVAAENVVDENt 298
Cdd:PRK09603   232 --VRYENDKYLIPFASLDANQRMEFDLKDPQGKIILLAGKKLTSRKIKELK-ENHLEWVeypmDILLNRHLAEPVMVGK- 307
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  299 gEILVQEGQKIDKETAQKIENSGVKSVNI-----YGEDEKVVKVIGNNFVDIKA-HIDFNIDDLN--------------- 357
Cdd:PRK09603   308 -EVLLDMLTQLDKNKLEKIHDLGVQEFVIindlaLGHDASIIHSFSADSESLKLlKQTEKIDDENalaairihkvmkpgd 386
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  358 -ITEKVHYPTLKKIL---ETYTTEEDIKEALREKIGELVPKHIII---DDIIATMSYILNLPHGVGRVDDIDHLGNRRLR 430
Cdd:PRK09603   387 pVTTEVAKQFVKKLFfdpERYDLTMVGRMKMNHKLGLHVPDYITTlthEDIITTVKYLMKIKNNQGKIDDRDHLGNRRIR 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  431 SVGELLQNQFRIGLSRMERVVRERMTIQD--MDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSA 508
Cdd:PRK09603   467 AVGELLANELHSGLVKMQKTIKDKLTTMSgaFDSLMPHDLVNSKMITSTIMEFFMGGQLSQFMDQTNPLSEVTHKRRLSA 546
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  509 LGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVdkERGVVTDEIEYLTADE 588
Cdd:PRK09603   547 LGEGGLVKDRVGFEARDVHPTHYGRICPIETPEGQNIGLINTLSTFTRVNDLGFIEAPYKKV--VDGKVVGETIYLTAIQ 624
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  589 EEKYVFAQANEPLDEEGRFINKRVVARLrGGDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQRQA 668
Cdd:PRK09603   625 EDSHIIAPASTPIDEEGNILGDLIETRV-EGEIVLNEKSKVTLMDLSSSMLVGVAASLIPFLEHDDANRALMGTNMQRQA 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  669 VPLIKTESPIIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKRHSDGGK--DEYKLLKFKRSNQGTCINQKPLVDN 746
Cdd:PRK09603   704 VPLLRSDAPIVGTGIEKIIARDSWGAIKANRAGVVEKIDSKNIYILGEGKEEAyiDAYSLQKNLRTNQNTSFNQVPIVKV 783
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  747 GDEVKAGEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEEITRD 826
Cdd:PRK09603   784 GDKVEAGQIIADGPSMDRGELALGKNVRVAFMPWNGYNFEDAIVVSERITKDDIFTSTHIYEKEVDARELKHGVEEFTAD 863
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  827 IPNVGEDALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKV 906
Cdd:PRK09603   864 IPDVKEEALAHLDESGIVKVGTYVSAGMILVGKTSPKGEIKSTPEERLLRAIFGDKAGHVVNKSLYCPPSLEGTVIDVKV 943
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  907 FTR----------------------------------------------------------------------------- 909
Cdd:PRK09603   944 FTKkgyekdarvlsayeeekakldmehfdrltmlnreellrvssllsqaileepfshngkdykegdqipkeeiasinrft 1023
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  910 -----------------------------------------ENGDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGV 948
Cdd:PRK09603  1024 laslvkkyskevqnhyeitknnfleqkkvlgeeheeklsilEKDDILPNGVIKKVKLYIATKRKLKVGDKMAGRHGNKGI 1103
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  949 ISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLG------------------------------ 998
Cdd:PRK09603  1104 VSNIVPVADMPYTADGEPVDIVLNPLGVPSRMNIGQILEMHLGLVGKEFGkqiasmledktkdfakelrakmleianain 1183
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  999 ------------------------W----KVATPVFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMY 1050
Cdd:PRK09603  1184 ekdpltihalencsdeelleyakdWskgvKMAIPVFEGISQEKFYKLFELAKIAMDGKMDLYDGRTGEKMRERVNVGYMY 1263
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1051 MLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIVKG 1130
Cdd:PRK09603  1264 MIKLHHLVDEKVHARSTGPYSLVTHQPVGGKALFGGQRFGEMEVWALEAYGAAHTLKEMLTIKSDDIRGRENAYRAIAKG 1343
                         1370      1380      1390      1400
                   ....*....|....*....|....*....|....*....|....*...
gi 1120097870 1131 ENIPEPGIPESFKVLIKELQSLCLDVKVLSENADE------IEIKEND 1172
Cdd:PRK09603  1344 EQVGESEIPETFYVLTKELQSLALDINIFGDDVDEdgapkpIVIKEDD 1391
PRK14844 PRK14844
DNA-directed RNA polymerase subunit beta/beta';
12-1167 0e+00

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 173305 [Multi-domain]  Cd Length: 2836  Bit Score: 1034.19  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   12 RMSFSK-IDKVLEMPNLIEIQKRSYKWFL-----EEGLMEAFNDISPIQDYTGNLILEFVDYSLDgKPKYDQEECKERDV 85
Cdd:PRK14844    16 RVSYSRsIDLKDSLLDLVKVQKESYDSFTpknkgNERLEVIFHTIFPINDPLHRATIEFISCRVD-DPKYDESECIKRGI 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   86 TYAVPLKVKVRFIN-------------KETGE----------VKEQEVFMGDFPLMTEKGTFIINGAERVIVSQLVRSPG 142
Cdd:PRK14844    95 TFSAQVIASIRLVImqdgisldeyksiKESGDhsklatviksIEEQEVHFCELPMMTDKGTFIINGVEKVIVSQMHRSPG 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  143 PYYSVQIDKT---GKRLFSTTVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYgTDQEIINLFGEDERLLKt 219
Cdd:PRK14844   175 VFFDSDKGKTynsGKLIYSARVIPYRGSWLDIEFDVKDHLYFRIDRKRKLPISVLLKALGL-SNNDILDRFYEKIKYIK- 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  220 lEKDS-----VKSKEEGlIEVYKKLRPGEPPTVESASSLINSLFfDPKRYDlakvgrYKFNKKLSLVDRIVGFVAAENVV 294
Cdd:PRK14844   253 -HKDGwkvpfVPDKFKG-VRLPFDLMDVEGNVLLKANVRITSRL-AKKLYD------NELKEYLVPFDSICGLFLAEDLI 323
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  295 DENTGEILVQEGQKIDKETAQKIENSGVKSVNIYGEDEKVVKVIGNNFVDIKAHIDFNiDDLNITEKVHYPTLKKILET- 373
Cdd:PRK14844   324 DSASSTKILSAGESIKLEDIKKLELLSIDEISVLNIDNLSVGPYILNTLFLDENMSYQ-DALYEIYKVLRPGEVPVLEIv 402
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  374 --------YTTEE-DIKEALREKIGELVPKH-------IIIDDIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQ 437
Cdd:PRK14844   403 eeffrnlfFSPEYyDLSNIGRLKLNSYLGLNydedltvLTHEDIIEIVRKIVLLRDGQGSVDDIDHLGNRRVRSVGEFIE 482
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  438 NQFRIGLSRMERVVRERMTIQDMDTITPQALINIRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLSALGPGGLSRE 517
Cdd:PRK14844   483 NQFRTGLLKLERAVVDSMSTSSLDKVSPSDFINPKVLTNVLRDFFNSSQLSQFMDQTNPLSEITHKRRLSALGPGGLTRE 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  518 RAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINEYGFIEAPYRKVDKErgVVTDEIEYLTADEEEKYVFAQA 597
Cdd:PRK14844   563 RAGFEVRDVHPTHYGRICPIETPEGQNIGLINSLAIYARINKYGFIESPYRKVVNR--VVTDQIEYLSAIDEGLYYIADT 640
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  598 NEPLDEEGRFINKRVVARLrGGDIDVVPSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESP 677
Cdd:PRK14844   641 SAKLDENNCFVDDMLYCRY-AGSFVMVSSDQVSYIDVSPKQVISVAASLIPFLENDDANRALMGSNMQRQAVPLLKPTAP 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  678 IIGTGMEYIAAKDSGTVVVAKNDGIVERVTADKIIVKRHSDG-----GKDEYKLLKFKRSNQGTCINQKPLVDNGDEVKA 752
Cdd:PRK14844   720 LVATGMESFVASGSGAVVLAKRDGIVDSSDSNSIVIRAFDKErvnylDVDIYHLRKFQRSNHNTCINQKPLVCVGDYVKE 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  753 GEIIADGPSTDNGEIALGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEEITRDIPNVGE 832
Cdd:PRK14844   800 GDVIADGPAINSGELALGQNLLVAFMSWQGYNFEDSIIISSEVVKKDLFTSIHIEEFECVVHDTPLGSEKITRAIPGVNE 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  833 DALKNLDERGIIRIGAEVTSGDILVGKVTPKGETELTAEERLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTR--- 909
Cdd:PRK14844   880 ENLYHLDDSGIVKIGTRVGPGYILVGKVTPKPSLSLPPETKLLMTIFGEKSFDCADSSLYTSPDVEGTVIDVQVFTRrgv 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  910 -EN----------------------------------------------------------------------------- 911
Cdd:PRK14844   960 eENerallikqkeindfekerdyiinvtseyfydelkkllinsgsqdrekfdsiereqwwgiglknqsiseqvkslkkdf 1039
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  912 --------------------GDELPPGVNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVL 971
Cdd:PRK14844  1040 dekvshaiaqfkrkveklheGYDLPQGVSMSVKVFIAVKHSLQPGDKMAGRHGNKGVISRVVPVEDMPYLEDGTPVDIIL 1119
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  972 NPLGVPSRMNIGQVLEVHLGLAAKKLGWK--------------------------------------------------- 1000
Cdd:PRK14844  1120 NPLGVPSRMNVGQILETHVGWACKKLGEKvgnildeinkiksafckgirslnddnftkfaaayldnkkienidddeitas 1199
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1001 ------------------------------------------------------------------------VATPVFDG 1008
Cdd:PRK14844  1200 vlntpnknalndelnelvenylnscksaysnlrnflievyscgsnvsicnnirdisdnnliefarklrdgipVAAPVFEG 1279
                         1290      1300      1310      1320      1330      1340      1350      1360
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1009 AKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQR 1088
Cdd:PRK14844  1280 PKDEQIAKLFELAGLDNSGQAVLYDGCSGEKFDRKVTVGYMYMLKLHHLVDGKIHARSVGPYSLVTQQPLGGKSHFGGQR 1359
                         1370      1380      1390      1400      1410      1420      1430
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1120097870 1089 FGEMEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIVKGENIPEPGIPESFKVLIKELQSLCLDVKvLSENADEIE 1167
Cdd:PRK14844  1360 FGEMECWALQAYGAAYTLQEMLTVKSDDINGRVKIYESIIKGDSNFECGIPESFNVMIKELRSLCLNVD-LKQNDVVIE 1437
RNA_pol_B_RPB2 cd00653
RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. ...
27-1158 0e+00

RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase complex contains two related members of this family, in each case they are the two largest subunits.The clamp is a mobile structure that grips DNA during elongation.


Pssm-ID: 238353 [Multi-domain]  Cd Length: 866  Bit Score: 989.76  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   27 LIEIQKRSYKWFLEEGLMEAFNDISPIQDYT--GNLILEFVDYSLdGKP---------KYDQEECKERDVTYAVPLKVKV 95
Cdd:cd00653      1 LVKQQIDSFNYFLNVGLQEIVKSIPPITDTDddGRLKLKFGDIYL-GKPkveeggvtrKLTPNECRLRDLTYSAPLYVDI 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   96 RFINKETGEVKEQEVFMGDFPLMTE------------------------KGTFIINGAERVIVSQLVRSPGPYYsvQIDK 151
Cdd:cd00653     80 RLTVNDKGKIKEQEVFIGEIPIMLRsklcnlngltpeeliklgecpldpGGYFIINGTEKVIINQEQRSPNVII--VEDS 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  152 TGKRLFSTTVIPN----RGAWLEYETDS-NQIISVRIDRTRKlpftvfvralgygtdqeiinlfgederllktlekdsvk 226
Cdd:cd00653    158 KGKRIYTKTSIPSyspyRGSWLEVKSDKkKDRIYVRIDLKRQ-------------------------------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  227 skEEGLIEVYKKLRpgepptvesasslinslffdpkrydlakvgrykfnkklslvdrivgfvaaenvvdentgeilvqeg 306
Cdd:cd00653    200 --EEALKYIGKRFE------------------------------------------------------------------ 211
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  307 qkidketaqkiensgvksvniygedekvvkvignnfvdikahidfniddlnitekvhyptlkkiletytteedikealre 386
Cdd:cd00653        --------------------------------------------------------------------------------
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  387 kigelvpkhiiidDIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQDM--DTIT 464
Cdd:cd00653    212 -------------DLIYMIRKLILLVLGKGKLDDIDHLGNKRVRLAGELLQNLFRSGLKRLEREVKEKLQKQLSkkKDLT 278
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  465 PQALINIRPVVAAIKEFFGSSQ------------LSQFMDQTNPLSELTHKRRLSAlgpGGLSRERAGFEVRDVHHSHYG 532
Cdd:cd00653    279 PQLLINSKPITSGIKEFLATGNwgskrflmqrsgLSQVLDRLNPLSELSHKRRISS---LGLFRERKGFEVRDLHPSHWG 355
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  533 RMCPIETPEGPNIGLINSLSTYARINeyGFIEAPYRKVDKErgvvtdeieyltadeeekyvfaqanepldeegrfinkrv 612
Cdd:cd00653    356 RICPIETPEGENCGLVKNLALMARIS--GRIERPYRIVEKE--------------------------------------- 394
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  613 varlrggdidvvpsseVDYVDVSPQQIVSVATAMIPFLENDDANRALMGSNMQRQAVPLIKTESPIIGTGMEYIaakdsg 692
Cdd:cd00653    395 ----------------VTHIEISPSQILSVAASLIPFPEHNQSPRNLYQSNMQKQAVGTPALNQQYRMDTKLYL------ 452
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  693 tvvvakndgivervtadkiivkrhsdggkdeykLLKfkrsnqgtciNQKPLVDNGDEvkagEIIAdgpstdNGEIALGKN 772
Cdd:cd00653    453 ---------------------------------LLY----------PQKPLVGTGIE----EYIA------FGELPLGQN 479
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  773 LLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPEEITR-DIPNVGEDALKNLDERGIIRIGAEVT 851
Cdd:cd00653    480 AIVAVMSYSGYNFEDAIIINKSSVDRGFFRSIHYKKYEIELRKTKNGPEEITRgDIPNVSEEKLKNLDEDGIIRPGARVE 559
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  852 SGDILVGKVTPKGETELTAeerllraIFGEKAREVRDTSLKVPHGESGIIVDVKVFTREngdeLPPGVNVLVRVYIAKKR 931
Cdd:cd00653    560 PGDILVGKITPKGETESTP-------IFGEKARDVRDTSLKYPGGEKGIVDDVKIFSRE----LNDGGNKLVKVYIRQKR 628
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  932 KISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDGAKE 1011
Cdd:cd00653    629 KPQIGDKFASRHGQKGVISKILPQEDMPFTEDGIPPDIILNPHGFPSRMTIGQLLESLLGKAGALLGKFGDATPFDGAEE 708
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1012 TDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGE 1091
Cdd:cd00653    709 EDISELLGEAGLNYYGKEVLYDGRTGEPLEAPIFVGPVYYQRLKHMVDDKIHARSTGPYSLLTRQPLKGRSRGGGQRFGE 788
                         1130      1140      1150      1160      1170      1180      1190
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1120097870 1092 MEVWALEAYGAAHTLQEILTVKSDDVVGRVKTYEAIV----------KGENIPEPGIPESFKVLIKELQSLCLDVKV 1158
Cdd:cd00653    789 MERDALIAHGAAYLLQERLTIKSDDVVARVCVKCGIIlsanlcrlckKGTNISKVGIPYAFKLLFQELQSMNIDPRL 865
RNA_pol_Rpb2_6 pfam00562
RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of ...
696-1083 0e+00

RNA polymerase Rpb2, domain 6; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion. This domain is also involved in binding to Rpb1 and Rpb3. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).


Pssm-ID: 459854 [Multi-domain]  Cd Length: 371  Bit Score: 564.08  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  696 VAKNDGIVERVTADKIIVKrhSDGGKDE---YKLLKFKRSNQGT---CINQKPLVDNGDeVKAGeiiadgpstDNGEIAL 769
Cdd:pfam00562    1 VASLIPFVDHNQSPRNTYQ--CAMGKQAmgiYTLNKFYRSDQNTyvlCYPQKPLVKTGA-VEAG---------GFGELPL 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  770 GKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAeaRDTKLGP-EEITRDIPNVGEDALKNLDERGIIRIGA 848
Cdd:pfam00562   69 GQNAIVAVMSYTGYNQEDAIIINKSSVDRGFFTSIHIKEIEA--RKTKLGPiEEITRDIPNVSEEALKKLDEDGIVRVGA 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  849 EVTSGDILVGKVtpkGETELTaeeRLLRAIFGEKAREVRDTSLKVPHGESGIIVDVKVFTrengdeLPPGVNVLVRVYIA 928
Cdd:pfam00562  147 EVKPGDILVGKV---GPTELT---KLLRAIFGEKARDVKDTSLKVPPGEEGVVDDVIVFE------LPPGGIKMVKVYIR 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  929 KKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDG 1008
Cdd:pfam00562  215 QKRKPEVGDKFASRHGQKGVVSRILPQEDMPFTEDGIPPDIILNPHGVPSRMTIGQLLETHLGKAAALLGVFVDATPFDG 294
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1120097870 1009 AKET--DIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQ 1083
Cdd:pfam00562  295 ASTEveDIGELLEKAGYNYYGKEVLYDGRTGEPFEAPIFVGPIYYQKLKHMVDDKIHARSTGPYSLLTRQPLGGRAR 371
PRK08565 PRK08565
DNA-directed RNA polymerase subunit B; Provisional
34-1159 4.50e-125

DNA-directed RNA polymerase subunit B; Provisional


Pssm-ID: 236291 [Multi-domain]  Cd Length: 1103  Bit Score: 413.20  E-value: 4.50e-125
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   34 SYKWFLEEGLMEAFNDISPIQDYTGNLILEFVDYSLdGKPKYDQE----------ECKERDVTYAVPLKVKVRFINkETG 103
Cdd:PRK08565    21 SYNDFIERGLQEIVDEFGEIKTEIPGLKIVLGKIRV-GEPEIKEAdgserpitpmEARLRNLTYAAPLYLTMIPVE-NGI 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  104 EVKEQEVFMGDFPLM----------------TEKGT--------FIINGAERVIVSQ--------LVRSPGPYYSV-QID 150
Cdd:PRK08565    99 EYEPEEVKIGDLPIMvkskicplsglspdelIEIGEdpkdpggyFIINGSERVIVSQedlapnrvLVDKGEAGSSItHTA 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  151 KTgkrlFSTTVIPNRGAWLEYETDSnqIISVRIDRTR-KLPFTVFVRALGYGTDQEIINLFGEDER----LLKTLEKDS- 224
Cdd:PRK08565   179 KV----ISSRAGYRAQVTVERRKDG--TIYVSFPAVPgKIPFVILMRALGLETDRDIVYAVSLDPEiqqeLLPSLEQASs 252
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  225 -VKSKEEGLIEVYKKLRPGEPPTVesasslinslffdpkrydlakvgrykfnkklslvdRIvgfvaaenvvdentgeilv 303
Cdd:PRK08565   253 iAATVEDALDYIGKRVAIGQPREY-----------------------------------RI------------------- 278
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  304 qegqkidketaqkiensgvksvniygedEKVVKVIGNNFVdikAHIDfniddlnitekvhyptlkkiletyTTEED-IKE 382
Cdd:PRK08565   279 ----------------------------ERAEQILDKYLL---PHLG------------------------TSPEDrIKK 303
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  383 ALRekIGELVPKhiiiddiiatmsyILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMTIQ---- 458
Cdd:PRK08565   304 AYF--LGQMASK-------------LLELYLGRREPDDKDHYANKRLRLAGDLLAELFRVAFKQLVKDLKYQLEKSyarg 368
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  459 ---DMDTITPQALIN--IRPVVAAIKEFFGSSQLSQFMDQTNPLSELTHKRRLsaLGPggLSRERAGFEVRDVHHSHYGR 533
Cdd:PRK08565   369 rklDLRAIVRPDIITerIRHALATGNWVGGRTGVSQLLDRTNYLSTLSHLRRV--VSP--LSRGQPHFEARDLHGTQWGR 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  534 MCPIETPEGPNIGLINSLSTYARI--------------------------NEY-------------GFIEAPYRKVDKER 574
Cdd:PRK08565   445 ICPFETPEGPNCGLVKNLALMAQIsvgvdeeeveeilyelgvvpveeareEEYiswsrvylngrliGYHPDGEELAEKIR 524
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  575 -----GVVTDEIE---YLTADEEEKYVFAQANE---PL--DEEGRF-INKRVVARLRGGDI---DVVPSSEVDYVD---- 633
Cdd:PRK08565   525 elrrsGKISDEVNvayIETGEINEVYVNCDSGRvrrPLivVENGKPkLTREHVEKLKKGELtfdDLVKMGVIEYLDaeee 604
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  634 ------VSPQQ--------------IVSVATAMIPFLENDDANRALMGSNMQRQAVPL------IKTESPiiGTGMEYia 687
Cdd:PRK08565   605 enayvaLDPEDltpehthleiwppaILGITASIIPYPEHNQSPRNTYQAAMAKQSLGLyaanfrIRTDTR--GHLLHY-- 680
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  688 akdsgtvvvakndgivervtadkiivkrhsdggkdeykllkfkrsnqgtciNQKPLVdngdEVKAGEIIA--DGPStdng 765
Cdd:PRK08565   681 ---------------------------------------------------PQRPLV----QTRALEIIGynDRPA---- 701
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  766 eialGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKLGPE-EITRDIPNV----GEDALKNLDE 840
Cdd:PRK08565   702 ----GQNAVVAVLSYTGYNIEDAIIMNKASIERGLARSTFFRTYETEERKYPGGQEdKIEIPEPNVrgyrGEEYYRKLDE 777
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  841 RGIIRIGAEVTSGDILVGKVTPKGETELTAEERLlraifGEKARevRDTSLKVPHGESGIIVDVKVFTRENGdelppgvN 920
Cdd:PRK08565   778 DGIVSPEVEVKGGDVLIGKTSPPRFLEELEELSL-----GLQER--RDTSVTVRHGEKGIVDTVLITESPEG-------N 843
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  921 VLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWK 1000
Cdd:PRK08565   844 KLVKVRVRDLRIPELGDKFASRHGQKGVIGMLVPQEDMPFTEDGIVPDLIINPHAIPSRMTVGQLLESIAGKVAALEGRF 923
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1001 V-ATPvFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLG 1079
Cdd:PRK08565   924 VdATP-FYGEPEEELRKELLKLGYKPDGTEVMYDGRTGEKIKAPIFIGVVYYQKLHHMVADKIHARARGPVQILTRQPTE 1002
                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1080 GKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVV--------------GRVKTYEAIVKGE--NIPEPGIPESFK 1143
Cdd:PRK08565  1003 GRAREGGLRFGEMERDCLIGHGAAMLLKERLLDSSDKTTiyvcelcghiawydRRKNKYVCPIHGDkgNISPVEVSYAFK 1082
                         1290
                   ....*....|....*.
gi 1120097870 1144 VLIKELQSLCLDVKVL 1159
Cdd:PRK08565  1083 LLLQELMSMGISPRLK 1098
rpoB_arch TIGR03670
DNA-directed RNA polymerase subunit B; This model represents the archaeal version of ...
581-1157 1.13e-90

DNA-directed RNA polymerase subunit B; This model represents the archaeal version of DNA-directed RNA polymerase subunit B (rpoB) and is observed in all archaeal genomes.


Pssm-ID: 274713 [Multi-domain]  Cd Length: 599  Bit Score: 305.03  E-value: 1.13e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  581 IEYLTADEEEKYVFAQANEPLdeegrfinkrvvarlrggdidvvpSSEVDYVDVSPQQIVSVATAMIPFLENDDANRALM 660
Cdd:TIGR03670   92 IEYLDAEEEENAYIALDPEEL------------------------TPEHTHLEIDPSAILGIIASTIPYPEHNQSPRNTM 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  661 GSNMQRQAVPLIKTESPIigtgmeyiaakdsgtvvvakndgiveRVTADKiivkrHsdggkdeykLLKFKrsnqgtcinQ 740
Cdd:TIGR03670  148 GAAMAKQSLGLYAANYRI--------------------------RLDTRG-----H---------LLHYP---------Q 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  741 KPLVdngdEVKAGEIIA--DGPStdngeialGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSIHIEEYEAEARDTKL 818
Cdd:TIGR03670  179 KPLV----KTRVLELIGydDRPA--------GQNFVVAVMSYEGYNIEDALIMNKASIERGLARSTFFRTYEAEERRYPG 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  819 GPE-EITRDIPNV----GEDALKNLDERGIIRIGAEVTSGDILVGKVTPKgeteltaeeRLL--RAIFGEKAREVRDTSL 891
Cdd:TIGR03670  247 GQEdRFEIPEPDVrgyrGEEAYKHLDEDGIVYPEVEVKGGDVLIGKTSPP---------RFLeeLREFGLVTERRRDTSV 317
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  892 KVPHGESGIiVDvKVFTRENGDElppgvNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRILPVEDMPFLEDGTPLQVVL 971
Cdd:TIGR03670  318 TVRHGEKGI-VD-KVIITETEEG-----NKLVKVRVRDLRIPELGDKFASRHGQKGVIGMIVPQEDMPFTEDGIVPDLII 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  972 NPLGVPSRMNIGQVLEVHLGLAAKKLGWKV-ATPvFDGAKETDIAELLEECGYPVDGKLQLYDGRTGEPFDNRVTVGYMY 1050
Cdd:TIGR03670  391 NPHAIPSRMTVGQLLEMIAGKVAALEGRRVdGTP-FEGEPEEELRKELLKLGFKPDGKEVMYDGITGEKLEAEIFIGVIY 469
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1051 MLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVKSDDVV-------GRVKT 1123
Cdd:TIGR03670  470 YQKLHHMVADKIHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDESDKYVvyvcencGHIAW 549
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1120097870 1124 YEAI-------VKGE--NIPEPGIPESFKVLIKELQSLCLDVK 1157
Cdd:TIGR03670  550 EDKRkgtaycpVCGEtgDISPVEMSYAFKLLLDELKSLGISPR 592
PRK07225 PRK07225
DNA-directed RNA polymerase subunit B'; Validated
573-1163 4.77e-86

DNA-directed RNA polymerase subunit B'; Validated


Pssm-ID: 235972 [Multi-domain]  Cd Length: 605  Bit Score: 292.25  E-value: 4.77e-86
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  573 ERGVvtdeIEYLTADEEEKYVFAQANEPLDEEGRFInkrvvarlrggdidvvpssEVDyvdvsPQQIVSVATAMIPFLEN 652
Cdd:PRK07225    94 KQGV----IEYLDAEEEENAYIAVYEEDLTEEHTHL-------------------EID-----PSLILGIGAGMIPYPEH 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  653 DDANRALMGSNMQRQAVPL------IKTESpiigtgmeyiaakdsgtvvvakndgivervtadkiivKRHsdggkdeykL 726
Cdd:PRK07225   146 NASPRITMGAGMIKQSLGLpaanykLRPDT-------------------------------------RGH---------L 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  727 LKFKrsnqgtcinQKPLVdngdEVKAGEIIA--DGPStdngeialGKNLLVGFMTWEGYNYEDAILLSEELVMNDVLTSI 804
Cdd:PRK07225   180 LHYP---------QVPLV----KTQTQEIIGfdERPA--------GQNFVVAVMSYEGYNIEDALIMNKASIERGLGRSH 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  805 HIEEYEAEARDTKLGPE-EITRDIPNV----GEDALKNLDERGIIRIGAEVTSGDILVGKVTP------KGETELTAEER 873
Cdd:PRK07225   239 FFRTYEGEERRYPGGQEdRFEIPDKDVrgyrGEEAYRHLDEDGLVNPETEVKEGDVLIGKTSPprfleePDDFGISPEKR 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  874 llraifgekarevRDTSLKVPHGESGIIVDVKVFTRENGdelppgvNVLVRVYIAKKRKISVGDKMAGRHGNKGVISRIL 953
Cdd:PRK07225   319 -------------RETSVTMRSGEEGIVDTVILTETEEG-------SRLVKVRVRDLRIPELGDKFASRHGQKGVIGLIV 378
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  954 PVEDMPFLEDGTPLQVVLNPLGVPSRMNIGQVLEVHLGLAAKKLGWKVATPVFDGAKETDIAELLEECGYPVDGKLQLYD 1033
Cdd:PRK07225   379 PQEDMPFTESGVVPDLIINPHAIPSRMTVGHVLEMIGGKVGSLEGRRVDGTAFSGEDEEDLREALEKLGFEHTGKEVMYD 458
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1034 GRTGEPFDNRVTVGYMYMLKLHHLVDDKIHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEILTVK 1113
Cdd:PRK07225   459 GITGEKIEAEIFVGVIYYQKLHHMVANKLHARSRGPVQVLTRQPTEGRAREGGLRFGEMERDVLIGHGAAMLLKERLLDE 538
                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1120097870 1114 SDDVV-------GRVKTYEAI-------VKGE--NIPEPGIPESFKVLIKELQSLCLDVKVLSENA 1163
Cdd:PRK07225   539 SDKVEiyvcakcGMIAIYDKKrnrkycpICGEetDIYPVEMSYAFKLLLDELKSLGIAPRLELEDK 604
RNA_pol_Rpb2_1 pfam04563
RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. ...
26-474 1.32e-39

RNA polymerase beta subunit; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the protrusion domain. The other lobe (pfam04561) is nested within this domain.


Pssm-ID: 367994 [Multi-domain]  Cd Length: 396  Bit Score: 152.15  E-value: 1.32e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   26 NLIEIQKRSYKWFLEEGLME------AFNDISPIQDYTGN---LILEFVDYSLdGKPKYDQ----------EECKERDVT 86
Cdd:pfam04563    1 GLVRQQLDSFNEFVDNDLQKiidenaLIESEFEIQHPGENgdkLSLKFGQIRL-GKPMFDEtdgstreiypQECRLRNLT 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   87 YAVPLKVKVRFINKETGEVKEQEVFMGDFPLMTEK------------------------GTFIINGAERVIVSQLVRS-- 140
Cdd:pfam04563   80 YSAPLYVDLELSVYNGEDIKPIEVFIGRLPIMLRSnacilsgateselvklgecpldpgGYFIINGSEKVIVAQEHRSrn 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  141 -PGPYYSVQIDKTG---KRLFST--TVIPNRGAWLE-YETDSNQIISVRIDRTRK-LPFTVFVRALGYGTDQEIINLFGE 212
Cdd:pfam04563  160 hPIVFKKADPKKRGsvaSVRSSAeiSVRPDSTSWVNvLEYLSNGTIYFKFPYIKKeIPIVIILRALGFTSDREIFELICY 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  213 D-------ERLLKTLEKDSVKSkeeglievykklrpgePPTVESASSLINSLFFDPKRYDLAKVGRYKfnkklslvdriv 285
Cdd:pfam04563  240 DvndqqlqEELLPSLEEGFKIR----------------IQTQEQALDYIGGRGRAIFRMGRPREPRIK------------ 291
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  286 gfvAAENVVDEntgEILVqegqkidketaqkiensgvksvniygedekvvkvignnfvdikaHIDfnIDDLNITEKVHYp 365
Cdd:pfam04563  292 ---YAEEILQK---EVLP--------------------------------------------HLG--TYELDETKKAYF- 318
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  366 tlkkiletytteedikealrekigelvpkhiiiddIIATMSYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLS 445
Cdd:pfam04563  319 -----------------------------------IGYMIRRLLLLALGRREVDDRDHLGNKRLRLAGPLLASLFRVLFK 363
                          490       500       510
                   ....*....|....*....|....*....|.
gi 1120097870  446 RMERVVRERM--TIQDMDTITPQALINIRPV 474
Cdd:pfam04563  364 KLVRDVRERLqkVLGSPDDLMLQLLVNAKPI 394
RNA_pol_Rpb2_3 pfam04565
RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of ...
489-556 1.35e-36

RNA polymerase Rpb2, domain 3; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site.


Pssm-ID: 428011 [Multi-domain]  Cd Length: 67  Bit Score: 132.26  E-value: 1.35e-36
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1120097870  489 QFMDQTNPLSELTHKRRLSAlGPGGLSRERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYAR 556
Cdd:pfam04565    1 QVLDRTNYLSTLSHLRRVNS-PRGGLFREMKTTEVRDLHPSHWGRICPVETPEGPNCGLVKHLALYAR 67
RNA_pol_Rpb2_7 pfam04560
RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of ...
1085-1161 2.17e-36

RNA polymerase Rpb2, domain 7; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp. The clamp region (C-terminal) contains a zinc-binding motif. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription.


Pssm-ID: 461355 [Multi-domain]  Cd Length: 87  Bit Score: 132.33  E-value: 2.17e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870 1085 GGQRFGEMEVWALEAYGAAHTLQEILTVKSD----DVVGRVKTYEA-----IVKGENIPEPG-IPESFKVLIKELQSLCL 1154
Cdd:pfam04560    1 GGLRFGEMERWALIAYGAAHTLQERLTIKSDayevDVCGRCGLYAAynkcpICKGETDISPGyIPESFKLLFQELQSLGI 80

                   ....*..
gi 1120097870 1155 DVKVLSE 1161
Cdd:pfam04560   81 DPRLLLE 87
PRK09606 PRK09606
DNA-directed RNA polymerase subunit B''; Validated
18-559 2.25e-34

DNA-directed RNA polymerase subunit B''; Validated


Pssm-ID: 236587 [Multi-domain]  Cd Length: 494  Bit Score: 138.93  E-value: 2.25e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   18 IDKVLEMPNLIEIQKRSYKWFLEEGLMEAFNDISPIQ-DYTGNLILEFVDYSLdGKPK-----------YDQEeCKERDV 85
Cdd:PRK09606     9 SDAYFKEHRLVRHHIDSYNDFVDNGLQKIIDEQGPIEtEIEDGVYVELGKIRV-GKPVvkeadgsereiYPME-ARLRNL 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870   86 TYAVPLKVKVRfINKETGEVKEQEVFMGDFPLM-----------TEK-------------GTFIINGAERVIVSQLVRSP 141
Cdd:PRK09606    87 TYSAPLYLEMS-PVEGGEEEEPEEVYIGELPVMvgskicnlyglSEEelievgedpldpgGYFIVNGSERVLMTLEDLAP 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  142 GPYYSVQIDKTGKRLFSTTVIPNRG---AWLEYETDSNQIISVRIDR-TRKLPFTVFVRALGYGTDQEIINLFGEDER-- 215
Cdd:PRK09606   166 NKILVEKDERYGDRIEVAKVFSQRRgyrALVTVERNRDGLLEVSFPSvPGSIPFVILMRALGLETDEEIVEAVSDDPEiv 245
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  216 --LLKTLEKDSVKSKEEGLIEVYKKLRPGEPptvesasslinslffdpKRYdlakvgRYKfnkklslvdrivgfvAAENV 293
Cdd:PRK09606   246 kfMLENLEEAEVDTQEEALEYIGKRVAPGQT-----------------KEY------RIK---------------RAEYV 287
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  294 VDentgeilvqegqkidketaqkiensgvksvniygedekvvkvigNNFVdikAHIdfNIDdlnitekvhyptlkkilet 373
Cdd:PRK09606   288 ID--------------------------------------------RYLL---PHL--GVE------------------- 299
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  374 ytteediKEALREKIGELvpkhiiiddiiATM-SYILNLPHGVGRVDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVR 452
Cdd:PRK09606   300 -------PEVRRAKAHYL-----------GRMaEACFELALGRREEDDKDHYANKRLKLAGDLMEDLFRVAFNRLARDVK 361
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  453 ---ERMTIQDMDTitpqaliNIRPVVAA------IKEFF-------GSSQLSQFMDQTNPLSELTHKRRLSAlgpgGLSR 516
Cdd:PRK09606   362 yqlERANMRNREL-------SIKTAVRSdvlterLEHAMatgnwvgGRTGVSQLLDRTDYMATLSHLRRVVS----PLSR 430
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|...
gi 1120097870  517 ERAGFEVRDVHHSHYGRMCPIETPEGPNIGLINSLSTYARINE 559
Cdd:PRK09606   431 SQPHFEARDLHPTQWGRICPSETPEGPNCGLVKNFAQMVEIST 473
RNA_pol_Rpb2_45 pfam10385
RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent ...
567-635 1.30e-31

RNA polymerase beta subunit external 1 domain; RNA polymerases catalyze the DNA-dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared with three in eukaryotes (not including mitochondrial or chloroplast polymerases). This domain in prokaryotes spans the gap between domains 4 and 5 of the yeast protein. It is also known as the external 1 region of the polymerase and is bound in association with the external 2 region.


Pssm-ID: 463067 [Multi-domain]  Cd Length: 66  Bit Score: 117.85  E-value: 1.30e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1120097870  567 YRKVDKerGVVTDEIEYLTADEEEKYVFAQANEPLDEEGRFINKRVVARlRGGDIDVVPSSEVDYVDVS 635
Cdd:pfam10385    1 YRKVED--GKVTDEIVYLTADEEDGYVIAQANAPLDEDGRFVDERVSAR-YRGEFPLVPPEEVDYMDVS 66
RNA_pol_Rpb2_2 pfam04561
RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of ...
139-280 2.39e-17

RNA polymerase Rpb2, domain 2; RNA polymerases catalyze the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).


Pssm-ID: 398318 [Multi-domain]  Cd Length: 185  Bit Score: 81.24  E-value: 2.39e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  139 RSPGPYYSVQIDKTGKRLFST-TVIPNRGAWLEYETDSNQIISVRIDRTRKLPFTVFVRALGYGTDQEIINLFGED---- 213
Cdd:pfam04561    1 RSNGIYVEKELDKNGIIATYTsSLISNRGSWLKLEIDGKTLIWSRPSKKRKIPIVIFLKALGLVSDREILDRLCYDfndp 80
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1120097870  214 ----ERLLKTLEKDSVKSKEEGLIEVYK--KLRPGEPPTVESASSLINSlffdpkrydlaKVGRYKFNKKLSL 280
Cdd:pfam04561   81 qmleLLKPELEEAENIYTQEEALDYIGKgfALRRGEEPRLQRAREILYS-----------RDPKYNLNKHLGL 142
PRK00566 PRK00566
DNA-directed RNA polymerase subunit beta'; Provisional
279-327 1.11e-10

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 234794 [Multi-domain]  Cd Length: 1156  Bit Score: 66.24  E-value: 1.11e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:PRK00566   801 PLEERILGRVLAEDVVDPETGEVIVPAGTLIDEEIADKIEEAGIEEVKI 849
PRK09603 PRK09603
DNA-directed RNA polymerase subunit beta/beta';
279-327 5.17e-06

DNA-directed RNA polymerase subunit beta/beta';


Pssm-ID: 181983 [Multi-domain]  Cd Length: 2890  Bit Score: 51.08  E-value: 5.17e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:PRK09603  2199 PLEERIFGRVLLEDVIDPITNEILLYADTLIDEEGAKKVVEAGIKSITI 2247
rpoC2 PRK02597
DNA-directed RNA polymerase subunit beta'; Provisional
277-327 1.11e-05

DNA-directed RNA polymerase subunit beta'; Provisional


Pssm-ID: 235052 [Multi-domain]  Cd Length: 1331  Bit Score: 49.99  E-value: 1.11e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1120097870  277 KLSLVDRIVGFVAAENVVDeNTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:PRK02597   232 LIPLGDRLLGRVLAEDVVD-PEGEVIAERNTAIDPDLAKKIEKAGVEEVMV 281
RpoC COG0086
DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA ...
279-327 1.47e-05

DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; DNA-directed RNA polymerase, beta' subunit/160 kD subunit is part of the Pathway/BioSystem: RNA polymerase


Pssm-ID: 439856 [Multi-domain]  Cd Length: 1165  Bit Score: 49.39  E-value: 1.47e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1120097870  279 SLVDRIVGFVAAENVVDENTGEILVQEGQKIDKETAQKIENSGVKSVNI 327
Cdd:COG0086    800 PLKERILGRVAAEDVVDPGTGEVLVPAGTLIDEEVAEIIEEAGIDSVKV 848
M23_peptidase cd12797
M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; ...
686-762 4.76e-03

M23 family metallopeptidase, also known as beta-lytic metallopeptidase, and similar proteins; This model describes the metallopeptidase M23 family, which includes beta-lytic metallopeptidase and lysostaphin. Members of this family are zinc endopeptidases that lyse bacterial cell wall peptidoglycans; they cleave either the N-acylmuramoyl-Ala bond between the cell wall peptidoglycan and the cross-linking peptide (e.g. beta-lytic endopeptidase) or a bond within the cross-linking peptide (e.g. stapholysin, and lysostaphin). Beta-lytic metallopeptidase, formerly known as beta-lytic protease, has a preference for cleavage of Gly-X bonds and favors hydrophobic or apolar residues on either side. It inhibits growth of sensitive organisms and may potentially serve as an antimicrobial agent. Lysostaphin, produced by Staphylococcus genus, cleaves pentaglycine cross-bridges of cell wall peptidoglycan, acting as autolysins to maintain cell wall metabolism or as toxins and weapons against competing strains. Staphylolysin (also known as LasA) is implicated in a range of processes related to Pseudomonas virulence, including stimulating shedding of the ectodomain of cell surface heparan sulphate proteoglycan syndecan-1, and elastin degradation in connective tissue. Its active site is less constricted and contains a five-coordinate zinc ion with trigonal bipyramidal geometry and two metal-bound water molecules, possibly contributing to its activity against a wider range of substrates than those used by related lytic enzymes, consistent with its multiple roles in Pseudomonas virulence. The family includes members that do not appear to have the conserved zinc-binding site and might be lipoproteins lacking proteolytic activity.


Pssm-ID: 410984 [Multi-domain]  Cd Length: 85  Bit Score: 37.19  E-value: 4.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1120097870  686 IAAKdSGTVVVAKNDGIVERVTADK-----IIVkRHSDGGKDEYKLLKfkrsnqgtcinqKPLVDNGDEVKAGEIIA--- 757
Cdd:cd12797      6 IAAP-EGTPVYAAADGTVVFAGWDGgygnyVII-DHGNGYYTLYAHLS------------SILVKVGQRVKKGQVIGtvg 71

                   ....*.
gi 1120097870  758 -DGPST 762
Cdd:cd12797     72 nTGRST 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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