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Conserved domains on  [gi|1122394877|ref|WP_074052670|]
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type II toxin-antitoxin system RelE/ParE family toxin [Xanthomonas vesicatoria]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10007814)

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Gene Ontology:  GO:0110001|GO:0090729
PubMed:  20143871|20487277|28279904|15718296

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
5-99 1.12e-17

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


:

Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.07  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   5 VRFTQQAREDLARLYDWLLQRAegNFTVAERALQAIRDGVTVLKLAPLSCRKA-GVADPFLRELVIGfgasGYVLLFEVE 83
Cdd:COG3668     3 VRWTPEAEADLEEIYDYIAEDW--GPEAAERYLDEIEEAIELLAEFPELGRPRpELRVPGLRELVVG----PYVIFYRVD 76

                          90
                  ....*....|....*.
gi 1122394877  84 SDQVVtVLAVRHQRED 99
Cdd:COG3668    77 DDTVE-ILRVLHGRRD 91
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
5-99 1.12e-17

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.07  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   5 VRFTQQAREDLARLYDWLLQRAegNFTVAERALQAIRDGVTVLKLAPLSCRKA-GVADPFLRELVIGfgasGYVLLFEVE 83
Cdd:COG3668     3 VRWTPEAEADLEEIYDYIAEDW--GPEAAERYLDEIEEAIELLAEFPELGRPRpELRVPGLRELVVG----PYVIFYRVD 76

                          90
                  ....*....|....*.
gi 1122394877  84 SDQVVtVLAVRHQRED 99
Cdd:COG3668    77 DDTVE-ILRVLHGRRD 91
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 5-99 2.40e-13

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 60.14  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   5 VRFTQQAREDLARLYDWLlqrAEGNFTVAERALQAIRDGVTVLKLAPLSCRKAGVADPfLRELVIGFGasGYVLLFEVES 84
Cdd:pfam05016   1 VILTPKALKDLKKIADYI---AQDNPDAAERFLKALEEALELLAENPALGRPLPEGGL-KGLRRIRIG--DYRIIYRIDD 74

                          90
                  ....*....|....*.
gi 1122394877  85 DQ-VVTVLAVRHQRED 99
Cdd:pfam05016  75 DDlVILILRVGHRRRD 90
 
Name Accession Description Interval E-value
ParE COG3668
Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];
5-99 1.12e-17

Plasmid stabilization system protein ParE [Mobilome: prophages, transposons];


Pssm-ID: 442885  Cd Length: 96  Bit Score: 71.07  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   5 VRFTQQAREDLARLYDWLLQRAegNFTVAERALQAIRDGVTVLKLAPLSCRKA-GVADPFLRELVIGfgasGYVLLFEVE 83
Cdd:COG3668     3 VRWTPEAEADLEEIYDYIAEDW--GPEAAERYLDEIEEAIELLAEFPELGRPRpELRVPGLRELVVG----PYVIFYRVD 76

                          90
                  ....*....|....*.
gi 1122394877  84 SDQVVtVLAVRHQRED 99
Cdd:COG3668    77 DDTVE-ILRVLHGRRD 91
ParE_toxin pfam05016
ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II ...
 5-99 2.40e-13

ParE toxin of type II toxin-antitoxin system, parDE; ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralized by the antitoxin ParD. The family also encompasses RelE/ParE described in.


Pssm-ID: 398610 [Multi-domain]  Cd Length: 91  Bit Score: 60.14  E-value: 2.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   5 VRFTQQAREDLARLYDWLlqrAEGNFTVAERALQAIRDGVTVLKLAPLSCRKAGVADPfLRELVIGFGasGYVLLFEVES 84
Cdd:pfam05016   1 VILTPKALKDLKKIADYI---AQDNPDAAERFLKALEEALELLAENPALGRPLPEGGL-KGLRRIRIG--DYRIIYRIDD 74

                          90
                  ....*....|....*.
gi 1122394877  85 DQ-VVTVLAVRHQRED 99
Cdd:pfam05016  75 DDlVILILRVGHRRRD 90
RelE COG2026
mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense ...
 3-102 4.54e-05

mRNA-degrading endonuclease RelE, toxin component of the RelBE toxin-antitoxin system [Defense mechanisms];


Pssm-ID: 441629  Cd Length: 85  Bit Score: 38.64  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1122394877   3 FSVRFTQQAREDLARLydwllqraegNFTVAERALQAIRDgvtvLKLAPLSCRKA--GVADPFLReLVIGfgasGYVLLF 80
Cdd:COG2026     2 YKVEFTPRALKDLKKL----------DKKVQKRIKKKIEE----LAENPRPGGKKlkGSLKGLYR-LRVG----DYRIIY 62

                          90       100
                  ....*....|....*....|...
gi 1122394877  81 EVESDQ-VVTVLAVRHqREDDYQ 102
Cdd:COG2026    63 EIDDDElVVLVLAIGH-RRDVYR 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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