|
Name |
Accession |
Description |
Interval |
E-value |
| emrD |
PRK11652 |
multidrug transporter EmrD; |
1-394 |
0e+00 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 581.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 1 MKRHKNFNLLLMLVLLVAVGQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGM 80
Cdd:PRK11652 1 MKRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 81 SIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWS 160
Cdd:PRK11652 81 SIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 161 WRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGL 240
Cdd:PRK11652 161 WRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 241 SSMAVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLA 320
Cdd:PRK11652 241 SSMTVSILFILPIPAAFFGAWFAGRPNKRFSTLMWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGMLFPLA 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1123848306 321 TSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMMPQTGQGSLGLLMMLMGLLILLCWLPLASRFTRHQQPV 394
Cdd:PRK11652 321 TSGAMEPFPYLAGTAGALLGGLQNIGSGLAALLSAMLPQTGQFSLGLLMTLMGLLILLCWLPLATRMSHQGQPV 394
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
20-362 |
3.20e-84 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 261.36 E-value: 3.20e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:cd17320 11 GPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSM 179
Cdd:cd17320 91 LIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKWMPETRPEGAPRT---KLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAA 256
Cdd:cd17320 171 LLFLPETLPEEKRKPllsSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 257 FFGAWFAGRPNKRF--PTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGT 334
Cdd:cd17320 251 ILGSLLNGRLVRRFgpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGT 330
|
330 340
....*....|....*....|....*...
gi 1123848306 335 AGALVGGLQNIGSGVLAWLSAMMPQTGQ 362
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLLPNGTA 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
22-349 |
1.37e-36 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 136.26 E-value: 1.37e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:COG2814 24 LGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAK 181
Cdd:COG2814 104 ARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPETRPEgaPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGAW 261
Cdd:COG2814 184 LLPESRPA--ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 262 FAGRPNKRFPtLMWQSVICCLLAGLMMWIPGLLGimTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVG 340
Cdd:COG2814 262 LAGRLADRFG-RRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYN 338
|
....*....
gi 1123848306 341 GLQNIGSGV 349
Cdd:COG2814 339 SAFFLGGPL 347
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
20-343 |
2.96e-35 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 133.28 E-value: 2.96e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:TIGR00710 17 GPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVlcAGVTFSM 179
Cdd:TIGR00710 97 LVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL--AGILLSA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKW--MPETRPEGApRTKLLTSYKT---LFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIP 254
Cdd:TIGR00710 175 LIFfiLPETLPYEA-RIQISTYFETfllLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNII 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 255 AAFFGAWFAGRPNKRF--PTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLA 332
Cdd:TIGR00710 254 AMIFGGFLNGRFIKKWgaKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVA 333
|
330
....*....|.
gi 1123848306 333 GTAGALVGGLQ 343
Cdd:TIGR00710 334 GTASALFGTLR 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
28-357 |
1.10e-27 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 112.26 E-value: 1.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 28 IPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQG 107
Cdd:cd17324 19 QGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 108 MGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPETR 187
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 188 PEGAPRTKLLTSYKTLFGTGAFncYLLMLIGGLAGIAVFEACS--GVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAGR 265
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRL--RLAYLITFLLFGGFFALYTylAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 266 PNKRFPTLMWqSVICCLLAGLMMWIPGLLGIMtvWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNI 345
Cdd:cd17324 257 LADRGGRRAL-LIALLLLAAALLLLTLLGPSP--LLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNL 333
|
330
....*....|..
gi 1123848306 346 GSGVLAWLSAMM 357
Cdd:cd17324 334 GGALGAALGGLV 345
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-186 |
1.24e-25 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 100.80 E-value: 1.24e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 52 YLLTYGISQLFYGPLS----DRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00880 3 LLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPP 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1123848306 128 AQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPET 186
Cdd:TIGR00880 83 EERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
27-356 |
1.96e-25 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 106.15 E-value: 1.96e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 27 YIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQ 106
Cdd:PRK11102 10 YLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLH 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 107 GMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYaFLLVLCAGVTFSMAKWM-PE 185
Cdd:PRK11102 90 GLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF-WVLALAAILAAALVFFFiPE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 186 TRPEGApRTKL-----LTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGA 260
Cdd:PRK11102 169 TLPKER-RQPFhlrttIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFLFVMT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 261 WFAGRPNKRF-PTLMWQ-SVICCLLAGLMMWIPGLLGImTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGAL 338
Cdd:PRK11102 248 IINSRFVRRVgALNMLRfGLWIQFIMGIWLVVSALLDL-GFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMAGTASSL 326
|
330
....*....|....*....
gi 1123848306 339 VGGLQ-NIGSGVLAWLSAM 356
Cdd:PRK11102 327 AGTLRfGIGAIVGALLSLA 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
22-349 |
7.74e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.56 E-value: 7.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIA-DMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLI 100
Cdd:pfam07690 10 LGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 101 AASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMA 180
Cdd:pfam07690 90 VLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 181 KWMPET-----RPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEacSGVLMGAVLGLSSMAVSILFILPIPA 255
Cdd:pfam07690 170 LPRPPPeskrpKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLT--YLPLYQEVLGLSALLAGLLLGLGGLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 256 AFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGT 334
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKeERGT 327
|
330
....*....|....*
gi 1123848306 335 AGALVGGLQNIGSGV 349
Cdd:pfam07690 328 ASGLYNTAGSLGGAL 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-357 |
5.02e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 93.40 E-value: 5.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:cd17474 13 LGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILdTLWSWRACYAFLLVLCAGVTFSMAK 181
Cdd:cd17474 93 GRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPET-RPEGAPRTKLLTSYKTLFGTGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMAVSILFILPIPAAF 257
Cdd:cd17474 172 LLPEPkEKAKSSSATKLRDLKKALRGRGL---LTFLVSAFLYFFLYFAFltyLPFLLELLYGISPIIIGLLFAGWSVLLA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 258 FGAWFAGRPNKRF----PTLMWQSVICCLLAGLMMWIPGLlgimtvWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLA 332
Cdd:cd17474 249 LGSLFVGRLLKKRfgarRILVIGLLLYALSLLLLGFVPSL------ALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEER 322
|
330 340
....*....|....*....|....*
gi 1123848306 333 GTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLL 347
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
20-349 |
5.89e-20 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 90.31 E-value: 5.89e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:cd17321 8 AALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVtfsm 179
Cdd:cd17321 88 IAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA---- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 akwmpetrpegaprtklltsyktLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFG 259
Cdd:cd17321 164 -----------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 260 AWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTAGAL 338
Cdd:cd17321 221 APLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKeKAGAASGI 300
|
330
....*....|.
gi 1123848306 339 VGGLQNIGSGV 349
Cdd:cd17321 301 LNTARQLGGAL 311
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-343 |
2.99e-19 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 88.41 E-value: 2.99e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:PRK11043 18 GFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLcAGVTFSM 179
Cdd:PRK11043 98 LVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAI-TLLLILP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKWMPETRPEGAPRTKLLtSYKTLFGTGAFncyllmliggLAGIAVFEACSG----------VLMGAvLGLSSMAVSILF 249
Cdd:PRK11043 177 TLRLKPSKKARKQSQDAL-TFKQLLKSKTY----------LGNVLIFAACSAaffawltgspFILEQ-MGYSPADIGLSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 250 IlPIPAAFFGAWFAGR-------PNKRFPTLMWQSVICCllagLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:PRK11043 245 V-PQTIAFLVGGYGCRaalqkwgGEQLLPWLLVLFAVSV----IAIWLASLLSHPSLVPLLIPFCVMAAANGAIYPIVVA 319
|
330 340
....*....|....*....|.
gi 1123848306 323 GAMEPFPFLAGTAGALVGGLQ 343
Cdd:PRK11043 320 QALRPFPQATGKAAALQNTLQ 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
22-322 |
3.86e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 88.02 E-value: 3.86e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAK 181
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPETRPEGAPRT----KLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAF 257
Cdd:cd17325 170 LLPEPRPPPNKRAvsaaRLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASA 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123848306 258 FGAWFAGRPNKRFPTLMWqSVICCLLAGLMMWIPGLLGimTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:cd17325 250 LSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLA 311
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-265 |
5.41e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.40 E-value: 5.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:COG0477 28 LDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLcAGVTFSMAK 181
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL-GLLALVLRL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGAW 261
Cdd:COG0477 187 RLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
....
gi 1123848306 262 FAGR 265
Cdd:COG0477 267 LLLL 270
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
26-355 |
1.43e-17 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 83.53 E-value: 1.43e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 26 IYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAM 105
Cdd:PRK10473 21 MYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 106 QGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPE 185
Cdd:PRK10473 101 QGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 186 TRPEGAPRTKLLTSYKT-LFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLS----SMAVSILFILPIPAAFFGA 260
Cdd:PRK10473 181 TRPARAPAASSKPRENSeSLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSrgeyAIIMALTAGVSMTVSFSTP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 261 WFAGRPNKRfpTLMWQSVICCLLAGLMmwipgLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVG 340
Cdd:PRK10473 261 FALGIFKPR--TLMLTSQVLFLAAGIT-----LALSPSHAVSLFGITLICAGFSVGFGVAMSQALGPFSLRAGVASSTLG 333
|
330
....*....|....*
gi 1123848306 341 GLQNIGSGVLAWLSA 355
Cdd:PRK10473 334 IAQVCGSSLWIWLAA 348
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-357 |
5.95e-17 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 81.47 E-value: 5.95e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:cd17323 11 VTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAML 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSM 179
Cdd:cd17323 91 IILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKWMPETrpegaprtklltsyktlfgtgafnCYLLMLIGGLAGI--AVFEACSGVLMGaVLGLSSMAVSILFILPIPAAF 257
Cdd:cd17323 171 FLFLPIV------------------------LLLGLYVGLVYAIlyLFLTAFPYVFGE-VYGFSPGEVGLMYLPIGIGAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 258 FGAWFAGR------------------PNKRFPTLMWQSVicCLLAGLMM--WipgllGIMTVWTLLVPA-ALFFFGAGML 316
Cdd:cd17323 226 IGSIIGGRlsdyyyrrlkkknggkpePEARLPPAFIGAF--LFPIGLFIfgW-----TIYPHIHWIVPIiGSAFFGFGLM 298
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1123848306 317 FPLATSGA--MEPFPFLAGTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17323 299 LIFQSSLTylVDSYPKYAASALAANTLVRSIFAAIFPLFAQPM 341
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
30-357 |
3.26e-16 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 79.14 E-value: 3.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 30 AIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMG 109
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 110 TGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTfsmakwmpetrpe 189
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLA------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 190 gaprtkLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEacsgvlMGAVLGLSSMAVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:COG2271 179 ------LLRFWLLALAYFLVYFALYGFLTWLPTYLVEV------RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 270 FPTLMwqsVICCLLAGLMMWIPGLLGimTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSG 348
Cdd:COG2271 247 RKLVL---AIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGA 321
|
....*....
gi 1123848306 349 VLAWLSAMM 357
Cdd:COG2271 322 LGPLLVGYL 330
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
20-357 |
1.78e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 77.23 E-value: 1.78e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVL 99
Cdd:cd17503 8 AILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 100 IAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSM 179
Cdd:cd17503 88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AkwmpetrpegAPRTKLLTSYKTLFGTgafncyLLMLIGGLAGIAVFEACSgVLMGAVLGLSSMAVSILFILPIPAAFFG 259
Cdd:cd17503 168 P----------LLDLRLFKDRNFTLGL------LLSFLLGLGLFGAMFLLP-LYLQNVLGYSAFESGLVLAPGGLASAIL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 260 AWFAGRPNKRF---PTLMWQSVICCLLAGLMMWIPGLlgiMTVWTLLVPAALFFFGAGMLF-PLATSGAMEPFPFLAGTA 335
Cdd:cd17503 231 SPLVGRLLDKFgprLLLLAGLLLLALGTLLLAFLTPD---TSLWLIILPLFIRGLGMGLVFmPLNTLALNSLPPEQIGDA 307
|
330 340
....*....|....*....|...
gi 1123848306 336 GALVGGLQNIGSGV-LAWLSAMM 357
Cdd:cd17503 308 TALFNTIRQLGGSIgTALLATLL 330
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
22-357 |
1.06e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.77 E-value: 1.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDT--LWSWRACYAFLLVLCAGVTFSM 179
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKWMPETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSG------VLMGAVLGLSSMAVSILFILPI 253
Cdd:cd06174 170 LLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSfstllpLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 254 PAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGLLGIMTVWTLLvpAALFFFGAGMLFPLATSGAMEPFPF-LA 332
Cdd:cd06174 250 LAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLL--LLLLGFGLGGLLPLSFALIAELFPPeIR 327
|
330 340
....*....|....*....|....*
gi 1123848306 333 GTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd06174 328 GTAFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
22-357 |
9.54e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.22 E-value: 9.54e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:COG2223 19 GVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAK 181
Cdd:COG2223 99 LGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPET-RPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLS-SMAVSILFILPIPAAF-- 257
Cdd:COG2223 179 FLRDPpAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSaATAGLLAALFALLGALgr 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 258 -FGAWFAGRPNKRfPTLMWQSVICCLLAGLMMWIPGllgimTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:COG2223 259 pLGGWLSDRIGGR-RVLLIVFALMALGLLLLALALG-----SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTkNAGAV 332
|
330 340
....*....|....*....|..
gi 1123848306 336 GALVGGLQNIGSGVLAWLSAMM 357
Cdd:COG2223 333 YGLVGAAGGLGGFLGPLLFGAL 354
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
38-264 |
2.15e-13 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 71.12 E-value: 2.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 38 LNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMA 117
Cdd:PRK15402 43 FNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 118 RTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPET---RPEGAPRT 194
Cdd:PRK15402 123 YAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETagrVGEKLSLK 202
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1123848306 195 KLLTSYKTLFGTGAFNCYLLMLigGLAGIAVFE--ACSGVLMGAVLGLSSMAVSILFIlPIpaafFGAWFAG 264
Cdd:PRK15402 203 ELGRDYKLVLKNRRFVAGALAL--GLVSLPLLAwiALSPVILISGEQLSSYEYGLLQV-PV----FGALIAG 267
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-347 |
3.16e-10 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 61.04 E-value: 3.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 50 AAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQ 129
Cdd:cd17502 37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 130 LRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYaFLLVLCAGVTFSMAkwmpetrpegapRTKLLTSYKTLFGTGAF 209
Cdd:cd17502 117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCF-YINLPIGGLALALL------------RTILLSSIFGFLFGGAL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 210 NCYLLMLIgglagiavfeacsgVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAGR---PNKRFPTLMWQSVICCLLAGL 286
Cdd:cd17502 184 FGLIYYLP--------------LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGAlisKTGRYKPLIVIGTILMSVGAG 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1123848306 287 MMWIpgLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGS 347
Cdd:cd17502 250 LLTT--LTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPpADVGVATATNTFFRSLGG 309
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
43-320 |
9.66e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.55 E-value: 9.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 43 GAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPR 122
Cdd:cd17329 35 SIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 123 DLYEGAQLRHANSLLNMGILVSPLIAPLLGGILdTLWSWRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTK--LLTSY 200
Cdd:cd17329 115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL-LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKteILRGY 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 201 KTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAGRPNKRFPTLMWQSV-I 279
Cdd:cd17329 194 KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIgI 273
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1123848306 280 CCLLAGLMMwipgLLGIMTVWTLLVPAALFFFGAGMLFPLA 320
Cdd:cd17329 274 LLFAIGFAV----LAFANTLAVLILAMIVLTLGEMLVFPAV 310
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-330 |
1.19e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 59.51 E-value: 1.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVA-LNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLI 100
Cdd:cd17473 13 MAGAAIAPALPAIAQHfVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 101 AASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLwSWRacYAFLLVLCAGVTFSMA 180
Cdd:cd17473 93 ASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWR--APFLVYLLALPVLILV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 181 -KWMPETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFG 259
Cdd:cd17473 170 lLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIG 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1123848306 260 AWFAGRPNKRFPTLMWqsviccLLAGLMMWIPGLLGIMT---VWTLLVPAALFFFGAGMLFPLATSGAMEPFPF 330
Cdd:cd17473 250 ALLFGRLKRRLGKRRL------LAIGFALMALGFLLLALasgLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPP 317
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
26-318 |
1.58e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 26 IYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAM 105
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 106 QGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAgVTFSMAKWMPE 185
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL-LALLLVFLVKD 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 186 TRPEGAPRTKLLTSYKT-LFGTGAFNCYLLMLIGGLA--GIAVFEAcsgvLMGAVLGLSsmAVSILFILPIPAAFFGAWF 262
Cdd:cd17489 173 PPPVAAEEAEAGTRAFRrLVEKKVLPPALILFLASIAygAISTFLP----LYAAERGIS--NAGLFFTVYAIALLLSRPF 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1123848306 263 AGRPNKRFPTLMwQSVICCLLAGLMMWIPGLLGimTVWTLLVPAALFFFGAGMLFP 318
Cdd:cd17489 247 SGKLSDRKGPKT-VIIPGLLLLALGLLLLSFAG--SPWMLLLAAVLYGLGFGLLFP 299
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
21-360 |
1.59e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 59.13 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 21 QMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLI 100
Cdd:cd17504 9 MLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 101 AASAMQgMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMA 180
Cdd:cd17504 89 AGRALQ-GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 181 kwMPETRPEGAPRTKLLTSYKTLFGTGAFncyllMLIGGLAGIAVFEACSGVLMGAVL-GLSSMAVSIlfilpipAAFFG 259
Cdd:cd17504 168 --LIDLRLLRRRNVLLANITALLAGFGMF-----MVFQLLPQLLQLPTPTGFGLGITEaGLLLLPGAL-------VMLIA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 260 AWFAGRPNKRF---PTLMWQSVICCLLAGLMMWIPGllgimTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPF-LAGTA 335
Cdd:cd17504 234 GPLAGRLIARVgprRVLLIGLVISAVGLLLLALLHS-----SLWALVVALLLIGIGLGLAFASLPNIVVESVPPdRTGIA 308
|
330 340
....*....|....*....|....*
gi 1123848306 336 GALVGGLQNIGSGVLAWLSAMMPQT 360
Cdd:cd17504 309 TGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
60-318 |
2.02e-09 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 58.68 E-value: 2.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 60 QLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNM 139
Cdd:PRK15403 68 QWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 140 GILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPETRPEGA---PRTKLLTSYKTLFGTGAFNCYLLML 216
Cdd:PRK15403 148 IVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAvpfSAKSVLRDFRNVFRNRLFLTGAATL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 217 IGGLAGIAVFEACSGVLMGAVLGLSSMAVSI----LFILPIPAAFFGAWFAGRPNKrfPTLMWQSVIcCLLAGLMMWIPG 292
Cdd:PRK15403 228 SLSYIPMMSWVAVSPVILIDAGGMTTSQFAWtqvpVFGAVIVANAIVARFVKDPTE--PRFIWRAVP-IQLVGLALLIVG 304
|
250 260
....*....|....*....|....*..
gi 1123848306 293 LLGIMTVWTLLV-PAALFFFGAGMLFP 318
Cdd:PRK15403 305 NLLWPHVWLWSVlGTSLYAFGIGLIFP 331
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
43-322 |
3.97e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.99 E-value: 3.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 43 GAVQSVMAAYLLTYGISQLFYGPLSDRVG-----RRPVILVGMSIFMLATLVAITTHSLP------VLIAASAMQGMGTG 111
Cdd:COG2211 46 ALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYT 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 112 VGGVMARTLPRDLYEGAQLR-HANSLLNMGILVSPLIAPLLGGIL------DTLWSWRACYAFLLVLCAGVTFSMAKWMP 184
Cdd:COG2211 126 LVNIPYSALGAELTPDYEERtRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 185 ETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAG 264
Cdd:COG2211 206 ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWP 285
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1123848306 265 RPNKRFPTLMWqSVICCLLAGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:COG2211 286 RLAKRFGKKKA-FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-353 |
1.15e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 56.42 E-value: 1.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 30 AIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMG 109
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 110 TGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRacYAFLLVLCAGVTFSMAKWMpetrpe 189
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWR--WAFIIEGLLGLLLAVLWWF------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 190 gaprtKLLTSYKTLFGTGAFNCYLLMLIGGLAGIavfeacsgvlMGAVLGLSSMAVSILFILPIPAAFFGAWFAGRPNKR 269
Cdd:cd17319 177 -----YLRQVWGLALGYFGINYALYGLLTWLPTY----------LKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 270 FPTL--MWQSVICCLLAGLMMwipglLGIMTVWTLLVPAALF---FFGAGMLFPLATSGAMEPFPF-LAGTAGALVGGLQ 343
Cdd:cd17319 242 LLRGarRLVIIIGLLLAAVGL-----LLAYLTTSPVVAVILLslaGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
330
....*....|
gi 1123848306 344 NIGSGVLAWL 353
Cdd:cd17319 317 NLGGFVAPLL 326
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
49-322 |
6.00e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.14 E-value: 6.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 49 MAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMArtLPRDLYEGA 128
Cdd:cd17472 38 LGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVVMA--LLADLTREE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 129 QLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLTSYKTLFGTGA 208
Cdd:cd17472 116 NRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 209 FNC-YLLMLIGGLAGIAVFEACSGVLMGAVLGLSSM------AVSILFILPIPAAFfgawFAGRPNKRFPTLMwQSVICC 281
Cdd:cd17472 196 LLRlDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLwkvylpAILIGFILMVPFVI----YAEKKGKMKQVFV-SSILLI 270
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1123848306 282 LLAGLMMWipglLGIMTVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:cd17472 271 AVGFLLLL----FAATSLWLLIIGLIIFFIGFNLLEALLPS 307
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-353 |
1.25e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 53.32 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYEgaqlRHANSLLNM-------GILVSPLIAPLLGGiLDTLWSWRACYAFLLVLCAG 174
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYVAALGP----ETAASRLNLlhaffslGALLGPLLGGLLIL-LGLSLSWHLPYLILAVLLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 175 VTFSMAKW-MPETRPEGAPRTKLLTSYKTLFGTGAFncyLLMLIGGLAGIAVFEAC---SGVLMGAVLGLSSMAVSILFI 250
Cdd:COG0738 177 LALLFLRSkLPEIEEEEEEAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIgdwLPLYLKDVLGLSEATAALGLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 251 LPIPAAFFGAWFAGRPNKRF---PTLMWQSVICCLLAGLMMWIPGLlgimtvWTLLVPAALFFFGAGMLFPLATSGAMEP 327
Cdd:COG0738 254 LFWGGMTIGRFLGGFLLKRFgpvRLLRLSALLAAVGLLLALLAPGP------WLALIGLALVGLGLSLMFPTIFSLALDG 327
|
330 340
....*....|....*....|....*.
gi 1123848306 328 FPFLAGTAGALVGGLQNIGSGVLAWL 353
Cdd:COG0738 328 LGKRTAAAVSAVLIMGIVGGAIGPPL 353
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
22-329 |
3.08e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 51.84 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYlltyGISQLFY----GPLSDRVGRR-PVILVGMSIFMLATLVAITTHSl 96
Cdd:cd17490 10 FSQYVYVPFLSPYAESLGASLSMIGIILGAY----GISQMLLriplGILSDRIGKRkLFIIIGLLFTVLASLIMILFPS- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 97 PVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRacYAFLLVLCAGVT 176
Cdd:cd17490 85 PWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMR--APFLLAALAGVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 177 -FSMAKWMPETRPEGAPRTKLLTSYKTLFGTGafncyLLMLIGGLAGIAVFEACSGV-----LMGAVLGLSSMAVSILFI 250
Cdd:cd17490 163 gFILSLFIKEERREKKPVLTELKELLSVLKDK-----KLLFFSLLAILQQMITFSTTfgftpLIAKQLGASSFQLGLLSI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 251 LPIPAAFFGAWFAGRPNKRFPTLMWQSVICCLLAGL-MMWIPGllgIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP 329
Cdd:cd17490 238 IYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAyCFLIPF---APNLTLLYLLQALNGFGTGILFPLLMSLSIEGVP 314
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
51-173 |
6.29e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 51.09 E-value: 6.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 51 AYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAM----QGMGTGVGGVMARTLPRDlYE 126
Cdd:cd06179 40 AWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALigigAGTQGLGAAVASELVPNK-YR 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1123848306 127 GAQLRHANSLLNMGILVSPLIAPLLggILDTLWSWRACYAFLLVLCA 173
Cdd:cd06179 119 GLVQGVVNLVASPGSALGPLIAGAL--VEANAAGWRWIFYINAIFNA 163
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
21-349 |
7.51e-07 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 50.72 E-value: 7.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 21 QMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLI 100
Cdd:cd17476 11 QAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 101 AASAMQGMGTGVGGVMARTLPRDLYEGAQLRH-ANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAgVTFSM 179
Cdd:cd17476 91 ICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAA-IVAVA 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 180 AKWMpetrpegaprtklltsyktlfGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFG 259
Cdd:cd17476 170 AIFW---------------------TSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 260 AWFAGRPNKRFPT--LMWQSVICCLLAGLMMWIPglLGIMTVWTLLVPAALFF-FGAGMLFPLAT---SGAMEpfPFLAG 333
Cdd:cd17476 229 AITVGFLIARLPPsyIMAISMVAFLVGPILFATM--PVHQTYWAQAFPAMIVApFGMDFSFPAATiiaSNAVP--REYQG 304
|
330
....*....|....*.
gi 1123848306 334 TAGALVGGLQNIGSGV 349
Cdd:cd17476 305 LAGSLVNTVVNYGISI 320
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
24-188 |
1.30e-06 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 50.07 E-value: 1.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 24 QTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAAS 103
Cdd:TIGR00711 18 STIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFR 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 104 AMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWM 183
Cdd:TIGR00711 98 VIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFIL 177
|
....*
gi 1123848306 184 PETRP 188
Cdd:TIGR00711 178 PRDKP 182
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
20-317 |
3.80e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.38 E-value: 3.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 20 GQMAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAI-----TTH 94
Cdd:cd06173 11 SALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAllallGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 95 SLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACY---AFLLVL 171
Cdd:cd06173 91 SLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFainALSFLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 172 CAGVTFSMAKWMPETRPEGAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAG--IAVFEACSGVLMGAVLGLSSMAVSILF 249
Cdd:cd06173 171 SALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFAllGGALTVLLPLLAKEVLGGGAAGYGLLL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1123848306 250 ILPIPAAFFGAWFAGRPNKRFPTLMWqSVICCLLAGLMMWIpglLGIMTVWTLLVPAALFFFGAGMLF 317
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLV---LGLSPSLWLLLAALFLLGLAGGLF 314
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
25-183 |
3.90e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 48.57 E-value: 3.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 25 TIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASA 104
Cdd:PRK10504 27 TIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARV 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1123848306 105 MQGMGTGVGGVMARTLPRDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRacYAFLLVLCAGVTFSMAKWM 183
Cdd:PRK10504 107 LQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWH--WIFLINIPVGIIGAIATLM 183
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-351 |
5.53e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 5.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 22 MAQTIYIPAIADMAVALNVREGAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIA 101
Cdd:COG2807 32 PAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 102 ASAMQGMGTGVGGVMARTLPRDLYeGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAK 181
Cdd:COG2807 112 GTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLP 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 182 WMPETRPE------GAPRTKLLTSYKTLFGTGAFNCYLLMLIGGLAGIAVFEACSGVLMGAvlglSSMAVSILFILPIPA 255
Cdd:COG2807 191 LLRRRPAAaaaapaAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAAT----AGLLLSLFQLAGIPG 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 256 AFFGAWFAGRPNKRFPTLMWQSVICCLLAGLMMWIPGllgimtvWTLLVPAALFFFGAGMLFPLATSGAMEPFPfLAGTA 335
Cdd:COG2807 267 SLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG-------SLPWLWAVLLGLGQGGLFPLALTLIGLRAR-TPAEA 338
|
330
....*....|....*.
gi 1123848306 336 GALVGGLQNIGSGVLA 351
Cdd:COG2807 339 AALSGMAQSVGYLLAA 354
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
48-356 |
6.83e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.67 E-value: 6.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 48 VMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEG 127
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 128 AQLRHANSLLNMGILVS-PLIAPLLGGILDTLWSWRACYAFLLVLCAGVTF----------------SMAKWMPETRPEG 190
Cdd:TIGR00881 115 SERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLicflllrdspqscglpPAEEMPNEEPDGD 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 191 APRTKLLTSYKTLFGTGAFNCYLLMLIgGLAGIAVFEACSGVL------MGAVLGLSSMAVSILFILPIPAAFFGAWFAG 264
Cdd:TIGR00881 195 AEKKEEELTKKQIFLQYVLLNKVLWYI-SLGYVFVYVVRTGILdwsplyLTQEKGFSKEKASWAFTLYELGGLVGTLLAG 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 265 ------RPNKRFPTLM-WQSVICCLLAGLMMWIPGLLGIMTVwtLLVPAALFFFGAGMLFPLATSGAMepFPFLAGTAGA 337
Cdd:TIGR00881 274 wlsdklFNGRRGPLAVfFMALIIVSLLVYWLNPAANPLMDLI--CLFALGFLVYGPQMLIGVIASELA--PKKAAGTAAG 349
|
330
....*....|....*....
gi 1123848306 338 LVGGLQNIGSGVLAWLSAM 356
Cdd:TIGR00881 350 FVGFFAYLGGILAGLPLGY 368
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
48-357 |
1.58e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 48 VMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTL----PRD 123
Cdd:cd17316 41 LFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYvaefAPS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 124 LYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVtfsmakwmpetrpegaprtkLLTSYKTL 203
Cdd:cd17316 121 KRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLA--------------------LLLRRRTL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 204 FGTGAFNCYLLMLIGGLAGIAVFeacSGVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAGRPNKRfptlmWQSVICCLL 283
Cdd:cd17316 181 LLILLWFFISFGYYGLTTFLPTY---LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-----KTLVIGLIL 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1123848306 284 AGLMMWIPGLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFP-FLAGTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17316 253 SGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPtEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
58-355 |
3.43e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 58 ISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQ---LRHAN 134
Cdd:cd17333 46 IGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSatrLNVLH 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 135 SLLNMGILVSPLIAPLLGGILDTlWSWRACYAFLLVLCAGVTFSMAKWMPetRPEGAPRTKLLTSYKTLFGTGAFNCYLL 214
Cdd:cd17333 126 GFFGLGALIGPLIATSLLTSELS-WSWAYLIIGLIYLLLAILILLTLFPE--LPSARNPQQSVGAFSASASRLLRNPSII 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 215 ML-IGGLAGIAVFEACSGVLMGAVLGLSSMAVSILFIlpIPAAFFGAWFAGR----PNKRFPTLMWQSVICCLLAGLMMW 289
Cdd:cd17333 203 LGaLALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGY--LLSGFWVGITIGRllggPISRRIKPHTLLVLSGSGALLGLL 280
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1123848306 290 IpgLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPFLAGTAGALVGGLQNIGSGVLAWLSA 355
Cdd:cd17333 281 I--LLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-177 |
1.60e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 48 VMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEG 127
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1123848306 128 AQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRA--CYAFLLVLCAGVTF 177
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAafLFSAVLALIALLLL 370
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
43-355 |
1.99e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.95 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 43 GAVQSVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASA-MQGMGTGVGGVMARTLP 121
Cdd:cd17355 38 AVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGlLGGGGAGTLAAVAFATV 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 122 RDLYEGAQLRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPETRPEGAPRTKLLTSYK 201
Cdd:cd17355 118 AAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 202 TLFGTGAFNC----YLLMLIG------GLAGIAVFEACSGVLMGAVLGLSSMAVSILFILPIPAAFFGAWFAGRPNKRFP 271
Cdd:cd17355 198 SPGSTLKEALrsasFWLLALAfflcgfAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 272 TLmwqsvICCLLAGLMMWIPgLLGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPFPflaGTAGALVGGLQNIGSGVLA 351
Cdd:cd17355 278 LA-----ASYALRALGLALL-LLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFG---ARSYGTLFGLVFAPHQLGS 348
|
....
gi 1123848306 352 WLSA 355
Cdd:cd17355 349 ALGP 352
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
47-185 |
2.55e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 39.65 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 47 SVMAAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDlYE 126
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSE-YA 134
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 127 GAQLR-HANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPE 185
Cdd:TIGR00895 135 PKRFRgTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
136-322 |
5.48e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 5.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 136 LLNMGILVSPLIAPLLGGIL---DTLWSWRACYAFLLVLCAGVTFSMAKW---MPETRPEGAPRTKLLTSYKTLFGTGAF 209
Cdd:cd17332 144 FATIGGLLVTVLPPPLVAYFgggNASRGYFLTALIIGIIGIILLLICFFGtreRVVPPEEEKSKLPLLKSLKALLKNRPF 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 210 ncyLLMLIGGLAGIAVFEACSGVLM---GAVLGLSSMAVSILFILPIPAAFFGAWFagrpnkrFPTLMWQSVICCLLAGL 286
Cdd:cd17332 224 ---LILLLAYLLYFLAFNIVNTVLVyyfKYVLGGRAELVLLLLLILSGALLALLPW-------PPLKKRFGKKKAFFIGL 293
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1123848306 287 MMWIPGLLGIM-----TVWTLLVPAALFFFGAGMLFPLATS 322
Cdd:cd17332 294 LLAILGLLLLFflppgNLVLILVLAVLAGIGYGGANLLPWA 334
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
50-357 |
7.25e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.02 E-value: 7.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 50 AAYLLTYGISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMQGMGTGVGGVMARTLPRDLYEGAQ 129
Cdd:cd17312 45 SAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKE 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 130 LRHANSLLNMGILVSPLIAPLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKWMPETRPegaprtklltsyktlfgtgaf 209
Cdd:cd17312 125 RGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP--------------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 210 ncylLMLIGGLAGIAVFEACSGVL------MGAVLGLSSMAVSILFILPIPAAFFGAWFAG------RPNKRFPTLMWQS 277
Cdd:cd17312 184 ----YVWVLSLAYAFVYIVRYACLdwgplyLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGllsdklFGGRRAPIAVIYM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 278 VICCLLAGLMMWIPGllGIMTVWTLLVPAALFFFGAGMLFPLATSGAMEPfPFLAGTAGALVGGLQNIGSGVLAWLSAMM 357
Cdd:cd17312 260 LLMTLSLALFWFFPH--NKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR-KEAAGTATGFVGLFGYLGASLAGLPLGYI 336
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
57-182 |
7.80e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 38.49 E-value: 7.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1123848306 57 GISQLFYGPLSDRVGRRPVILVGMSIFMLATLVAITTHSLPVLIAASAMqgmgTGVGGVMARTLPrdLYEGAQLRHANSL 136
Cdd:pfam06609 92 AVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTL----LGVAAGPAGASP--LFIGELMSNKTKF 165
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1123848306 137 LNMGILVSPLIA-----PLLGGILDTLWSWRACYAFLLVLCAGVTFSMAKW 182
Cdd:pfam06609 166 LGLLIVSAPTIAmngagPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLIIIW 216
|
|
| |
