|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
23-432 |
2.34e-169 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 481.26 E-value: 2.34e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 23 KVVIASLIGTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASL 102
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLTL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 103 LTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTF 182
Cdd:cd17369 82 LLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGVF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 183 LLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATY 262
Cdd:cd17369 162 LLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVRAPLVEVLRRHWRALLLAIGLRLAEN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 263 TLFYIMTVYSMTFSTTpaaqgGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLL 342
Cdd:cd17369 242 VLFYLFTTFALSYATQ-----TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 343 GSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQA-NYGLFYVGIYLA 421
Cdd:cd17369 317 TGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAaTGSWWPVALYLA 396
|
410
....*....|.
gi 1126561678 422 AMAALTLIALI 432
Cdd:cd17369 397 ALAVISLVAAL 407
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
31-428 |
5.47e-152 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 436.70 E-value: 5.47e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 31 GTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTV 110
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 111 VIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLLLSWLLT 190
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 191 DEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLFYIMTV 270
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKKRGPIAETLTKHRKPFLLGLGLVIATTTTFYLITT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 271 YSMTFSTTpaaqgGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGSGSQTMV 350
Cdd:TIGR00883 241 YLPTYLTQ-----TLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLF 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1126561678 351 MAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYG-LFYVGIYLAAMAALTL 428
Cdd:TIGR00883 316 FFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTGdWYAIGYYLAALALIGL 394
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
25-438 |
2.03e-79 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 251.45 E-value: 2.03e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 25 VIASLIGTAIEFFDFYIYATAAVIvFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLT 104
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALY-FAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 105 MGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLL 184
Cdd:cd17367 80 MAAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 185 LSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLtKHMRVTVLGTFIMLATYTL 264
Cdd:cd17367 160 LQHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 265 FYIMTVYSMTFSTTPAaqgglDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITtliLLFALFVFPPLLGS 344
Cdd:cd17367 239 FYTWTTYLQKFLVNTA-----GFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFG---IGGTLATVPLLSAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 345 GSQT-MVMAYLLIGLSLMGLTFGP--MGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYGLFYVGIYLA 421
Cdd:cd17367 311 DHTDsPYTAFALVLVGLVFLSGYTsiNAVVKAELFPTHVRALGVGLPYALAVAIFGGTAPYVALWLKSIGHEWVFFWYVA 390
|
410
....*....|....*..
gi 1126561678 422 AMAALTLIALIATKETR 438
Cdd:cd17367 391 GLIAISLVVYLRMPETR 407
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
13-440 |
6.80e-77 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 246.18 E-value: 6.80e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 13 QDATPVNSRS-KVVIASLIGTAIEFFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDR 91
Cdd:PRK09952 11 DEGTLSLSRArRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDR 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 92 VGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGA 171
Cdd:PRK09952 91 LGRKRMLMLTVWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGY 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 172 PIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVF--AKIAKAKKQVKVPLGTLLTKHMR 249
Cdd:PRK09952 171 GVGLLLSTGLVSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFeqQQHEQAAAKKRIPVIEALLRHPG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 250 VTVLGTFIMLATYTLFYIMTVYSMTFSTTpaaqgGLDFPRNDVLWM-LMMAVIGFgLMVPIAGLLADRFGRRKsMIVITT 328
Cdd:PRK09952 251 AFLKIIALRLCELLTMYIVTAFALNYSTQ-----NLGLPRELFLNIgLLVGGLSC-LTIPCFAWLADRFGRRR-VYITGA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 329 LILLFALFVFPPLLGSGSQTMVM--AYLLIGLSlMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATW 406
Cdd:PRK09952 324 LIGTLSAFPFFMALEAQSIFWIVffSIMLANIA-HDMVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAA 402
|
410 420 430
....*....|....*....|....*....|....*.
gi 1126561678 407 LQANYG--LFYVGIYLAAMAALTLIALIATKETRHQ 440
Cdd:PRK09952 403 LVTYFGgsWHSVAIYLLAGCLISAMTALLMKDNQRA 438
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
23-442 |
1.50e-69 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 228.44 E-value: 1.50e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 23 KVVIASLIGTAIEFFDFYIYATAAvIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASL 102
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 103 LTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTF 182
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 183 LLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFA----KIAKAKKQV-----KVPLGTLLTKHMRVTVL 253
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQqhvdKLEQGDREGlqdgpKVSFKEIATKHWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 254 GTFIMLATYTLFYIMTVYSMTFSTTpaaqgGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLF 333
Cdd:PRK10642 255 CIGLVIATNVTYYMLLTYMPSYLSH-----NLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVILGSVALFVL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 334 ALFVFpPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVsSILGASVAPYIATWL-QANYG 412
Cdd:PRK10642 330 AIPAF-ILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLvESTQN 407
|
410 420 430
....*....|....*....|....*....|
gi 1126561678 413 LFYVGIYLAAMAALTLIALIATKETRHQSL 442
Cdd:PRK10642 408 LMMPAYYLMVVAVIGLITGVTMKETANRPL 437
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
25-437 |
1.62e-69 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 226.10 E-value: 1.62e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 25 VIASLIGTAIEFFDFYIYATAAVIVfPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLT 104
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYI-GRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 105 MGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLL 184
Cdd:cd17368 80 MALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 185 LSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETpvFAKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTL 264
Cdd:cd17368 160 LSLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEET--EAFLERKARPTRRELFALLANNRRIILLGMLLVAGSTVT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 265 FYIMTVYSMTFSTTPaaqggLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGS 344
Cdd:cd17368 238 FYFTTVYTPTYAKTV-----LGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAA 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 345 GSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYG-LFYVGIYLAAM 423
Cdd:cd17368 313 PSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTGsPLAPAWYLMGA 392
|
410
....*....|....
gi 1126561678 424 AALTLIALIATKET 437
Cdd:cd17368 393 ALLGLLATLMLRET 406
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
25-437 |
1.33e-65 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 214.91 E-value: 1.33e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 25 VIASLIGTAIEFFDFYIYATAAVIVfPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLT 104
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTI-GKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 105 MGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLL 184
Cdd:cd17366 80 MAASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 185 LSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLhetpvfakiakakkqvkvplgtlltkhmrvtVLGTFIMLATYTL 264
Cdd:cd17366 160 LTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL-------------------------------LICIGLVLVFNVT 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 265 FYIMTVYSMTFSTtpaaqGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFpPLLGS 344
Cdd:cd17366 209 NYMLLSYMPSYLE-----ETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAF-LLMNS 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 345 GSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYGLFYV-GIYLAAM 423
Cdd:cd17366 283 GSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATGNPLMpAYYLMVA 362
|
410
....*....|....
gi 1126561678 424 AALTLIALIATKET 437
Cdd:cd17366 363 AVVGLVAVLFLTET 376
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
3-429 |
1.72e-52 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 181.93 E-value: 1.72e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 3 ASIATSIDNEQDATPVNSRSKVVIASLIGTAIEFFDFYIYATAAvIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGS 82
Cdd:PRK10406 2 AESTVTADSKLTSSDTRRRIWAIVGASSGNLVEWFDFYVYSFCS-LYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 83 AVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRAL 162
Cdd:PRK10406 81 WLFGRIADKHGRKKSMLISVCMMCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 163 YGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETpvfakiAKAKKQVKVPLGT 242
Cdd:PRK10406 161 YASFQYVTLIGGQLLALLVVVVLQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET------SQQETRALKEAGS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 243 L--LTKHMRvtvlgTFIMLATYTL-----FYIMTVYSMTFSTTPAaqgGLDFPRNDVLwmLMMAVIGFGLMVPIAGLLAD 315
Cdd:PRK10406 235 LkgLWRNRR-----AFIMVLGFTAagslcFYTFTTYMQKYLVNTA---GMHANVASGI--MTAALFVFMLIQPLIGALSD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 316 RFGRRKSMIVITTLILLFALFVFPPLLGSGSQtmVMAYLLIGLSLMGLTF--GPMGALLPELFPTEVRYTGASFSYNVSS 393
Cdd:PRK10406 305 KIGRRTSMLCFGSLAALFTVPILSALQNVSSP--YAAFGLVMCALLIVSFytSISGILKAEMFPAQVRALGVGLSYAVAN 382
|
410 420 430
....*....|....*....|....*....|....*.
gi 1126561678 394 ILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLI 429
Cdd:PRK10406 383 ALFGGSAEYVALSLKSIGMETAFFWYVTLMAVVAFL 418
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-432 |
5.12e-49 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 170.48 E-value: 5.12e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 25 VIASLIGTAIEFFDFYIYATAAVIVFPHIffpqgDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLT 104
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 105 MGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFAngtfLL 184
Cdd:cd17316 76 FGLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLA----AL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 185 LSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRvslhetpvfakiakakkqvkvplgtlltkhmRVTVLGTFIMLATYTL 264
Cdd:cd17316 144 VASLLIPLLSGDWGWRILFLIGALPALLALLLR-------------------------------RRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 265 FYIMTVYSMTFSTTpaaqgGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFppLLGS 344
Cdd:cd17316 193 YYGLTTFLPTYLQT-----VLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF--YLLS 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 345 GSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMA 424
Cdd:cd17316 266 GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLA 345
|
....*...
gi 1126561678 425 ALTLIALI 432
Cdd:cd17316 346 IVALIVAL 353
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
15-407 |
3.52e-48 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 170.51 E-value: 3.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 15 ATPVNSRSKV--VIASLIGTAIEFFDFYI---YATAavivFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFG 89
Cdd:PRK15075 5 TPAASRESKAraILRVTSGNFLEMFDFFLfgfYATA----IAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 90 DRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQL 169
Cdd:PRK15075 81 DRVGRRKGLIVTLSIMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 170 GAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKiAKAKKQVKVPLGTLLtKHMR 249
Cdd:PRK15075 161 SQQVAVVFAALLGYLLNQWLSPAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLA-RKHRPSMREIFRSLA-ANWR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 250 VTVLGTFIMLATYTLFYIMTVYSMTFSTTPaaqggLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTL 329
Cdd:PRK15075 239 IVLAGMLMVAMTTVSFYLITVYTPTFGKTV-----LHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1126561678 330 ILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWL 407
Cdd:PRK15075 314 AILTAYPALSWLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIFGGFTPAISTWL 391
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-434 |
1.07e-28 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 116.25 E-value: 1.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 26 IASLIGTAIEFFDFYIYATAAVIVFPHiffpqGDPTAATLQSLATFAIAFVArpIGSAVFGHFGDRVGRKVTLVASLLTM 105
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAE-----FGLDEAEAGLLGTVTLAGGA--IGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 106 GISTVVIGLLPGYESigimapllLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANG-TFLL 184
Cdd:cd17371 75 AVFTLLCGFAQNYWQ--------LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLlAALL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 185 LSWLLTDeqfmsWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVP--LGTLLTKHMRVTVLGTFIMLAty 262
Cdd:cd17371 147 FPLLPPE-----IAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRpsLRELFSPPLLRTTLLASLLAT-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 263 tlFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPplL 342
Cdd:cd17371 220 --GALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFF--L 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 343 GSGSQTMVMAYLLIGLSLMGLtFGPMGALLPELFPTEVRYTGASFSYNVSSILGAsVAPYIATWLQANYGLfyvGIYLAA 422
Cdd:cd17371 296 PLSPTLILILGFPLGFFASGP-FSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA-LFPFLVGFLATSGSL---GTAIAV 370
|
410
....*....|..
gi 1126561678 423 MAALTLIALIAT 434
Cdd:cd17371 371 FAAVYYIAGLVL 382
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
23-442 |
1.43e-25 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 108.13 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 23 KVVIASLIGTaIEFFDFYIYATAAVIVFPHIFFPQ----GDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTL 98
Cdd:pfam00083 1 VALVAALGGF-LFGYDTGVIGAFLTLIDFFKNFGLsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 99 VASLLTMGISTVVIGLLPGYESIGimaplLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFA 178
Cdd:pfam00083 80 LIANVLFVIGAVLQGAAKGKWSVY-----QLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 179 NGTFlllswLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVF-------------------------------A 227
Cdd:pfam00083 155 YIFG-----LGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWlvekgrleearevlaklrgvpdvdreldeikD 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 228 KIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLF-YIMtvYSMTFSTTPAAQGGLDfprNDVLWMLMMAVIGFgLM 306
Cdd:pfam00083 230 SLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLtGIN--AIFYYSTTIFENLGLS---DSFLVTIIVGVVNF-VF 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 307 VPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLL----GSGSQTMVM-AYLLIGLSLMGLTFGPMGA-LLPELFPTEV 380
Cdd:pfam00083 304 TFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVALlgvsKSDWAGIVAiVFIALFIAFFAMGWGPVPWvIVSELFPLSV 383
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126561678 381 RYTGASFSYNVSSILGAsVAPYIATWLQANYGLFYVGIYLAAMAAL-TLIALIATKETRHQSL 442
Cdd:pfam00083 384 RSKAMALATAANWLANF-LIGFLFPIITDAIGLGYTFFIFAGLLVLfIIFVFFFVPETKGRTL 445
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-432 |
4.46e-24 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 102.64 E-value: 4.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 14 DATPVNSRSKVVIASLIGTAIEFFDFYIYATAAVIVFPHIFFpqgdpTAATLQSLatFAIAFVARPIGSAVFGHFGDRVG 93
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGL-----SAAQLGLL--ASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 94 RKVTLVASLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPI 173
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 174 GFFFANgtfLLLSWLLTdeqfmSWGWRVPFIFSAVLVLiglyvrvslhetpvfakiakakkqvkvplgtlltkhmrVTVL 253
Cdd:COG2271 146 GGALAP---PLLGWLLA-----AFGWRAAFLILGLPGL--------------------------------------LLAL 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 254 GTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLF 333
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 334 ALFVFPPLLGSGsqTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVSSILGASVAPYIATWLQANYGL 413
Cdd:COG2271 260 LALLLLALLPSP--ALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGY 336
|
410
....*....|....*....
gi 1126561678 414 FYVGIYLAAMAALTLIALI 432
Cdd:COG2271 337 QAAFLLLAALALLAALLAL 355
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-440 |
7.05e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 96.87 E-value: 7.05e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 19 NSRSKVVIASLIGTAIEFFDFYIYATAAVIVFPHIFFpqgdpTAATLQSLatFAIAFVARPIGSAVFGHFGDRVGRKVTL 98
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGL-----SAAQLGLL--FAIPVLVGALLRIPLGFLVDRFGPRRVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 99 VASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFA 178
Cdd:COG2223 74 LIGLLLLGIGLLLLALAVSYW--------LLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 179 NgtfLLLSWLLTdeqfmSWGWRVPF-IFSAVLVLIGLYVRVSLHETPVFAKiAKAKKQVKVPLGTLLTKHmrvTVLGTFI 257
Cdd:COG2223 146 A---FLAPLLIA-----AFGWRNAFlILGILLLVVAVLAWLFLRDPPAGAA-AAAKASLRDQLEALRDPR---FWLLSLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 258 MLATYTLFYIMTVYSMTFsttpaAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFV 337
Cdd:COG2223 214 YFGTFGSFIGFSSWLPPY-----LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 338 fppLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSiLGASVAPYIATWLQANYGLFYVG 417
Cdd:COG2223 289 ---ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG-LGGFLGPLLFGALLDATGSYTAA 364
|
410 420
....*....|....*....|....
gi 1126561678 418 -IYLAAMAALTLIALIATKETRHQ 440
Cdd:COG2223 365 fLVFAVLALVALVLTLLLYRRPRR 388
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
21-432 |
2.10e-18 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 86.91 E-value: 2.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 21 RSKVVIASLIGTAIEFFDFyiyataaVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVA 100
Cdd:PRK12307 16 QKNALFSAWLGYVFDGFDF-------MLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 101 SLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFAng 180
Cdd:PRK12307 89 SIVAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIA-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 181 tflllswlltdEQFM-----SWGWRVPFIFSAVLVLIGLYVRVSLHETpvfAKIAKAKKQVKVPLGTLLTKHMRVTVLGT 255
Cdd:PRK12307 159 -----------AYFMpsfaeAYGWRAAFFVGLLPVLLVIYIRARAPES---KEWEEAKLSGKGKHSQSAWSVFSLSMKGL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 256 F-------IMLATYTLFYIMTVYSMTFSTTPAAQGGLDFprNDVLWMLMMAVIGFGLMVP--IAGLLADRFGRRKSMIV- 325
Cdd:PRK12307 225 FnraqfplTLCVFIVLFSIFGANWPIFGLLPTYLAGEGF--DTGVVSNLMTAAAFGTVLGniVWGLCADRIGLKKTFSIg 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 326 -ITTLILLFALFVFPpllgsgsqtmVMAYLLIGLSLMGLTFGPMG--ALLPEL----FPTEVRYTGASFSYNVSSIlGAS 398
Cdd:PRK12307 303 lLMSFLFIFPLFRIP----------QDNYLLLGACLFGLMATNVGvgGLVPKFlydyFPLEVRGLGTGLIYNLAAT-SGT 371
|
410 420 430
....*....|....*....|....*....|....
gi 1126561678 399 VAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:PRK12307 372 FNSMAATWLGITMGLGAALTFIVAFWTATILLII 405
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-314 |
9.65e-18 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 83.32 E-value: 9.65e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 11 NEQDATPVNSRSKVVIASLIGTAIEFFDFYIYATAAVIVfphiffpQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGD 90
Cdd:COG0477 2 SSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSI-------AADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 91 RVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLG 170
Cdd:COG0477 75 RYGRKRVLLIGLLLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 171 APIGFFFANGTFLLLSWLltdeqfmsWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRV 250
Cdd:COG0477 147 IGLGLALGPLLGGLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLAL 218
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126561678 251 TVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLA 314
Cdd:COG0477 219 LLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLL 282
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-397 |
4.85e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 81.94 E-value: 4.85e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 15 ATPVNSRSKVVIASLIGTAIEFFDFYIYATAAVIVfphiffpQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGR 94
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLI-------AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 95 KVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIG 174
Cdd:COG2814 75 RRVLLLGLLLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLG 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 175 FFFAngtFLLLSWLLTdeqfmSWGWRVPFIFSAVLVLIGLYVrvslhetpVFAKIAKAKKQVKVPLGTLLTKHMRVTVLG 254
Cdd:COG2814 147 PALG---PLLGGLLAD-----LFGWRWVFLVNAVLALLALLL--------LLRLLPESRPAARARLRGSLRELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 255 TFIMLAtytLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVIttliLLFA 334
Cdd:COG2814 211 LLLLLA---FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG----LLLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126561678 335 LFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGA 397
Cdd:COG2814 284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
71-435 |
3.01e-16 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 79.93 E-value: 3.01e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 71 FAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALL 150
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 151 ATENAPAHKRALYGSFPQLGAPIGFFFAngtfLLLSWLLTDeqfmSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIA 230
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIG----PLLGGLLAD----ALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 231 KAKKQVKVPLGtlltkhMRVTVLGTFIMLATYTLFYIMTVYSMTFSTTPA-AQGGLDFPRNDVLWMLMMAVIGFGLMVPI 309
Cdd:cd17325 181 RAVSAARLRSG------LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 310 AGLLADRFGRRKsmiVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRytGASFS- 388
Cdd:cd17325 255 AGKLSDRIGRKP---LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLG-LGLVFPATLALLADIVPPEGR--GTAMGl 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1126561678 389 YNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIATK 435
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
23-413 |
3.77e-16 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 80.51 E-value: 3.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 23 KVVIASLIGTAIEFFDFYIYAtaavIVFPHIF--FPQGDPTAATLQSlatfaIAFVARPIGSAVFGHFGDRVGRKVTLVA 100
Cdd:PRK03893 20 KAFSAAWLGYLLDGFDFVLIT----LVLTEVQgeFGLTTVQAASLIS-----AAFISRWFGGLLLGAMGDRYGRRLAMVI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 101 SLLTMGISTVVIGLLPGYESIGImaplllalARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANg 180
Cdd:PRK03893 91 SIVLFSVGTLACGFAPGYWTLFI--------ARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAA- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 181 tfLLLSWLLTdeqfmSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRV--TVLGTFIM 258
Cdd:PRK03893 162 --QVYSLVVP-----VWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIinILLTLAAA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 259 LATYTLFYIMTVYS--MTFSTTPAAQGGLDF------PRNDVLWMLMMAVI----------------------------- 301
Cdd:PRK03893 235 AALWFCFAGNLQNAaiVAVLGLLCAAIFISFmvqssgKRWPTGVMLMVVVLfaflyswpiqallptylktdlgydphtva 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 302 ------GFGLMVP--IAGLLADRFGRRKSMiviTTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTfgpMGALLP 373
Cdd:PRK03893 315 nvlffsGFGAAVGccVGGFLGDWLGTRKAY---VCSLLISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQG---ISGLLP 388
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1126561678 374 EL----FPTEVRYTGASFSYNVSSiLGASVAPYIATWLQANYGL 413
Cdd:PRK03893 389 KLiggyFDTEQRAAGLGFTYNVGA-LGGALAPILGALIAQRLDL 431
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-397 |
2.06e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.91 E-value: 2.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 29 LIGTAIEFFDFYIYATAAVIVFPHIFfpqgDPTAATLQSLATFAIAFVArpIGSAVFGHFGDRVGRKVTLVASLLTMGIS 108
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL----GISPTEIGLLLTLFSLGYA--LAQPLAGRLSDRFGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 109 TVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFAngtFLLLSWL 188
Cdd:pfam07690 76 LLLLLFASSL--------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG---PLLGGLL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 189 LTdeqfmSWGWRVPFIFSAVLVLIGLyVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRVTVLGTFImlatyTLFYIM 268
Cdd:pfam07690 145 AS-----LFGWRAAFLILAILSLLAA-VLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL-----ALLLFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 269 TVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGSGSQT 348
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1126561678 349 MVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGA 397
Cdd:pfam07690 294 LLLALLLLGFG-FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGA 341
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
71-433 |
3.79e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 67.23 E-value: 3.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 71 FAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAALL 150
Cdd:cd17365 40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQS--------VLQLALLRFLTGLGLGAAMPNAITL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 151 ATENAPAHKRALYGSFPQLGAPIGfffANGTFLLLSWLLTdeqfmSWGWRVPFIFSAVLVLIGLyvrvslhetpvfakia 230
Cdd:cd17365 112 VSEYAPARRRSLAVTLMFCGYPLG---AALGGFLAAALIP-----AFGWRSVFLLGGVPPLILL---------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 231 kakkqvkvplgtlltkhmrVTVLGTFIMLATYtlFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIA 310
Cdd:cd17365 168 -------------------PLLRGTLLLWVTF--FMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 311 GLLADRFGRRKsmiviTTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGL--TFGPMGALLPELFPTEVRYTGASFS 388
Cdd:cd17365 227 GWLADRFGPKR-----VLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVngAQVGLYALAARFYPTEVRATGVGWA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1126561678 389 YNVSSiLGASVAPYIATWL-QANYGLFYVGIYLAAMAALTLIALIA 433
Cdd:cd17365 302 LGVGR-LGAILGPLLGGLLlAAGLGPESVFLALAIPAALGALAVLL 346
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-407 |
3.84e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 64.30 E-value: 3.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 9 IDNEQDATPVNSRS-KVVIASLIGTAIEFFDFYIYATAAvivfPHIFfPQGDPTAATLQSLATFAIAFVArpIGSAVFGH 87
Cdd:TIGR00895 2 VQNNIRKQPLSRYQwRAIILSFLIMLMDGYDLAAMGFAA----PAIS-AEWGLDPVQLGFLFSAGLIGMA--FGALFFGP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 88 FGDRVGRKVTLVASLLTMGISTVVIGLLPGYESigimapllLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFP 167
Cdd:TIGR00895 75 LADRIGRRRVLLWSILLFSVFTLLCALATNVTQ--------LLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 168 QLGAPIGfffANGTFLLLSWLLTDeqfmsWGWRVPFIFSAVL-VLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTK 246
Cdd:TIGR00895 147 FCGYPIG---AAVGGFLAGWLIPV-----FGWRSLFYVGGIApLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQM 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 247 HMRV-------------------------TVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGldfpRNDVLWMLMMAVI 301
Cdd:TIGR00895 219 QAEAqsalpeqkstqgtkrsvfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMVELG----FSLSLAATGGALF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 302 GFGLMVP--IAGLLADRFGRRksmiVITTLILLFALFVFpplLGSGSQTMVMAYLLIGLSLMGLTFGP---MGALLPELF 376
Cdd:TIGR00895 295 NFGGVIGsiIFGWLADRLGPR----VTALLLLLGAVFAV---LVGSTLFSPTLLLLLGAIAGFFVNGGqsgLYALMALFY 367
|
410 420 430
....*....|....*....|....*....|.
gi 1126561678 377 PTEVRYTGASFSYNVSSiLGASVAPYIATWL 407
Cdd:TIGR00895 368 PTAIRATGVGWAIGIGR-LGAIIGPILAGYL 397
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
60-432 |
3.97e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 64.11 E-value: 3.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 60 PTAATLQSLATFAIAfvarpIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLG 139
Cdd:cd17324 34 AQAGLLVSAYALGYA-----LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 140 LGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFAngtfLLLSWLLTDeqfmSWGWRVPFIFSAVLVLIG-LYVRV 218
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG----RPLGGLLGQ----LLGWRAAFLAIAVLALLAaLLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 219 SLHETPVFAKIakAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLFYimTVYSMTFSTTPaaqgglDFPRNDVLWMLMM 298
Cdd:cd17324 173 LLPSLPPKKPG--SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALY--TYLAPFLTDVP------GFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 299 AVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGSGsqtmvmayLLIGLSLMGLTFGPMGALLPELF-- 376
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLL--------LLVGLVLWGLGFFAAHSALQTRVlr 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1126561678 377 -PTEVRYTGASFsYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd17324 315 lAPEARGLASSL-YLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-432 |
6.26e-11 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 63.60 E-value: 6.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 36 FFDFYIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLL 115
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 116 PGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFAngtFLLLSWLLTdeqFM 195
Cdd:cd06174 82 PSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILG---PLLGGILAS---SL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 196 SWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVPLGTLLTKHMRVtvlGTFIMLATYTLFYIMTVYSMTF 275
Cdd:cd06174 148 GFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKN---PGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 276 STTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVITtlILLFALFVFPPLLGSGSQTMVMAYLL 355
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG--LLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126561678 356 IGLSLMGLTFGPMgALLPELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd06174 303 LGFGLGGLLPLSF-ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
70-434 |
1.80e-10 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 61.83 E-value: 1.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 70 TFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAAL 149
Cdd:cd17317 30 VQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 150 LATENAPAHKRALYGSFpqlgapIGFFFANGTFLL--LSWLLTDEQFMSWGWRVPFIFSAVLVLIGLyvrvslhetpvfa 227
Cdd:cd17317 102 LGMEIVGPKYRSFVGIL------FGLFWALGYMLLalLAYLIRDWRWLQLAISLPGLLFLLLLWWLP------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 228 kiakakkqvkvplgtlltkhmRVTVLGTFIMLATYTLFYIMTVYSMTFSttpaaqggldfpRNDVLWMLMMAVIGFgLMV 307
Cdd:cd17317 163 ---------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLG------------GNLYLNFFLSGLVEI-PAY 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 308 PIAGLLADRFGRRKSMI---VITTLILLFALFVFPpllgsGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTG 384
Cdd:cd17317 209 FLALLLLDRLGRRWTLSgslLLAGLACLVTALLPD-----DENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTG 283
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1126561678 385 ASFSYNVSSIlGASVAPYIATWLQanyglFYVGIYLAAMAALTLIALIAT 434
Cdd:cd17317 284 VGLCSTVARV-GAILAPFIVLLGK-----IGPLLPLIIFGVLALLGGLLT 327
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
84-434 |
2.53e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.23 E-value: 2.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 84 VFGHFGDRVG-----RKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALArFGQGLGLGGEWGGAALLATENAPAH 158
Cdd:COG2211 65 LIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYL-LLGLAYTLVNIPYSALGAELTPDYE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 159 KRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQfmSWGWRVPFIFSAVLVLIGLYVrvSLHETPVFAKIAKAKKQVKV 238
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLL--TFFGTKERPVPEEEKVSLKE 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 239 PLGTLLTKhmrvtvlGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFG 318
Cdd:COG2211 220 SLKALLKN-------RPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 319 RRKSMIVIttLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFP-----TEVRYTGASFS-YNVS 392
Cdd:COG2211 293 KKKAFIIG--LLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewkTGRRREGLYFGiFTFA 370
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1126561678 393 SILGASVAPYIATWLQANYGlfYVGIYLAAMAALTLIALIAT 434
Cdd:COG2211 371 IKLGQALAGALAGLLLALFG--YVAGAAQSPSALTGIRLLFF 410
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
28-438 |
5.92e-10 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 61.12 E-value: 5.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 28 SLIGTAIEFFDFYIYATAAvivfpHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGI 107
Cdd:cd17357 17 GVVNAPQEVFKEFINDTLV-----DRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 108 STVVIGLlpgyeSIGIMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFanGTFLLLSW 187
Cdd:cd17357 92 SSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILL--GQVFGLPS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 188 LLTDEQfmswGWRVPFIFSAVLVLIGLYVRVSLHETPVF-----AKIAKAKKQVKVPLGTLLTKHM----------RVTV 252
Cdd:cd17357 165 VLGTET----LWPYLLFFPGIPALLQLAALPFFPESPKFlliskGDEEEAEKSLKFLRGIEDDVDQeleeikkeseQMGD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 253 LGTFIMLATYT-------LFYIMTVYSMT----------FSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVpiAGLLAD 315
Cdd:cd17357 241 QKQVSLMQLLRdpslrlpLLLVLVVSASQqfsginaiffYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIV--GPFLIE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 316 RFGRRKSMIvITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLM-GLTF----GPMGALLP-ELFPTEVRYTGASFSY 389
Cdd:cd17357 319 KVGRRPLLL-ISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLfIFFFaiglGPIPWFIGaELFPQAPRSAAQSLGS 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 1126561678 390 NVSSiLGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIATKETR 438
Cdd:cd17357 398 SVNW-TSNFIVGMAFPPLQSIGGGFVFIIFAIPCALFLLYLYRYLPETK 445
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
70-428 |
3.32e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 58.87 E-value: 3.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 70 TFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIgimaplllALARFGQGLGLGGEWGGAAL 149
Cdd:TIGR00898 132 TQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVF--------LVFRLLVGMGIGGIWVQAVV 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 150 LATENAPAHKRALYGSFpqlgapIGFFFANGTFLL--LSWLLTDEQFMSWGWRVPFIFSAVLVLI------GLYVRVSLH 221
Cdd:TIGR00898 204 LNTEFLPKKQRAIVGTL------IQVFFSLGLVLLplVAYFIPDWRWLQLAVSLPTFLFFLLSWFvpesprWLISQGRIE 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 222 ETPVFAKIAKAKKQVKVPLGTL---LTKHMRVTVLGTFIM-------LATYTLFYIMTVYSMTFS--TTPAAQGGLDFpr 289
Cdd:TIGR00898 278 EALKILQRIAKINGKKLPAEVLslsLEKDLSSSKKQYSFLdlfrtpnLRKTTLCLMMLWFTTAFSyyGLVLDLGNLGG-- 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 290 NDVLWMLMMAVIGFGLMVpIAGLLADRFGRRKSMIVITTL--ILLFALFVFPPLLGSGSQTMVMaylligLSLMGLTFGP 367
Cdd:TIGR00898 356 NIYLDLFISGLVELPAKL-ITLLLIDRLGRRYTMAASLLLagVALLLLLFVPVDLYFLRTALAV------LGKFGITSAF 428
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126561678 368 MGALL--PELFPTEVRYTGASFSyNVSSILGASVAPYIA----TWLQANYGLFYVGIYLAAMAALTL 428
Cdd:TIGR00898 429 QMVYLytAELYPTVVRNLGVGVC-STMARVGSIISPFLVylgeKWLFLPLVLFGGLALLAGILTLFL 494
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
80-429 |
4.23e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.97 E-value: 4.23e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 80 IGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHK 159
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVW--------VLIVGRFLLGLGVGLASVLVPLYISEIAPAKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 160 RALYGSFPQLGAPIGFFFANGTFLLLSwlltdeQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFakiakakkqvkvp 239
Cdd:cd17315 121 RGALGTLNQLMITFGILLAYLLGLALS------LSPPGWWRLMFALAAVPALLQLLLMFFLPESRAL------------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 240 lgtlltkhmrVTVLGTFIMLA----TYTLFYIMTVYSMTFSTTPAAQGGldfprndVLWMLMMAVIGFglmvpIAGLLAD 315
Cdd:cd17315 182 ----------LVGVGLQLLQQltgiNAVMYYAPTIFKSAGGGTASILAS-------IIVGVVNLLATL-----VAIRLVD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 316 RFGRRK----SMIVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALL-PELFPTEVRYTGASFSYN 390
Cdd:cd17315 240 KVGRRPllliGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGKGMAIATL 319
|
330 340 350
....*....|....*....|....*....|....*....
gi 1126561678 391 VSSILGASVAPYIATWLQAnYGLFYVGIYLAAMAALTLI 429
Cdd:cd17315 320 VNWIFNFIVGLTFLIMVST-IGLAGVFIFFAAVCLLALV 357
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
84-434 |
4.35e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.97 E-value: 4.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 84 VFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHKRA-- 161
Cdd:cd17474 53 VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAka 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 162 --LYGSFpqLGAPIGFFFANGTFLLLswlltdeqfmsWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQVKVP 239
Cdd:cd17474 125 mgLYEAA--LGLGIAVGPLLGGLLAA-----------ISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 240 LGTLLTKHMRVTVLGTFIMLATY--TLFYIMTVYSMTFSTTPAAQGGLDFPrndvlWMLMMAVIGFGLmvpiAGLLADRF 317
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAG-----WSVLLALGSLFV----GRLLKKRF 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 318 GRRKSMiVITTLILLFALFVFPPLLgsgSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTgASFSYNVSSILGA 397
Cdd:cd17474 263 GARRIL-VIGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT-ASSLYNFVRFLGQ 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 1126561678 398 SVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIAT 434
Cdd:cd17474 338 AVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
81-430 |
7.39e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.28 E-value: 7.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 81 GSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESigimapllLALARFGQGLGLGGEWGGAALLATENAPAHKR 160
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPS--------LLVARLLTGVGLGGALPNLIALTSEAVGPRLR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 161 ALYGSFPQLGAPIGFFFANgtflLLSWLLTDEQfmswGWRVPFIFSAV--LVLIGLYVRVsLHETPVFAKIAKAKKQVKV 238
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALAS----VIGVLAAGDA----AWRHIFYVGGVgpLLLVPLLMRW-LPESRAFAQAAGAGKQRAP 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 239 PLGTLLTKHMRVTVLGTFImlatyTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFG 318
Cdd:PRK11551 209 VLRALFGEGRATATLLLWI-----SYFFTLIVLYFLLNWLPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLR 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 319 RRKSMIVITTLIL--LFALfvfppLLGSGSQTMVMAYLLIGLSLMGLTfGPMGALLPELFPTEVRYTGASFSYNVSSiLG 396
Cdd:PRK11551 284 PRRVVLLIYAGILasLAAL-----AAAPSFAGMLLAGFAAGLFVVGGQ-SVLYALAPLFYPTQVRGTGVGAAVAVGR-LG 356
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1126561678 397 ASVAPYIATWL----QANYGLFYV---GIYLAAMAALTLIA 430
Cdd:PRK11551 357 SMAGPLLAGQLlalgRSTVGVIGAsipVILVAALAALLLVS 397
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
40-435 |
2.21e-07 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 53.11 E-value: 2.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 40 YIYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKvtlvASLLTMGISTVVIGLLPGYE 119
Cdd:TIGR00879 46 VIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRK----KSLLIIALLFVIGAILMGLA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 120 SIGiMAPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANG-TFLLLSWLLTDeqfmswG 198
Cdd:TIGR00879 122 AFA-LSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILVAYGfGSGKVSLNNTL------G 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 199 WRVPFIFSAVLVLIGLYVRVSLHETPVF----AKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLFYIM----TV 270
Cdd:TIGR00879 195 WRIPLGLQLIPAGLLFLGLFFLPESPRWlvgkGRVEEARKSLARLRGTSGEDKELLDELELIDIKRSIEKRSVQpswgSL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 271 YSMTFSTTPAA------QGGLDFPRNDVL---------------WMLMMAVIGFGLMVPIAGLLA----DRFGRRKsMIV 325
Cdd:TIGR00879 275 FSSTRRIRRRLflgvvlQWFQQFTGINAImyysptifenagvstDHAFLVSIIVGAVNFAFTFVAiflvDRFGRRP-LLL 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 326 ITTLILLFALFVFPPLLGSG--SQTMVMAYLLIGLSLM-----GLTFGPMGALLP-ELFPTEVRYTGASFS---YNVSSI 394
Cdd:TIGR00879 354 IGAAGMAICLFVLGILGASFvtGSSKSSGNVAIVFILLfiaffAMGWGPVPWVIVsEIFPLSLRPKGISIAvaaNWLANF 433
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 1126561678 395 LGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIATK 435
Cdd:TIGR00879 434 IVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFLPETK 474
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
75-428 |
4.89e-07 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 51.59 E-value: 4.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 75 FVARPIGSAVFGHFGD-RVGRKVTLVASLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATE 153
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY--------WVYAFLRFLTGFGRSGIGTCALVLATE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 154 NAPAHKRalygsfPQLGAPIGFFFANGtFLLLSWLltdEQFMSWGWRVPFIFSAVLVLIGLYVrvslheTPVFAKiakak 233
Cdd:cd17378 115 PVGPKWR------GQVGMSTFFFFVLG-FMSLPGI---AYLNGSSWRVLYFWTSIPALIYCIL------VYLFAR----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 234 kqvkvplgtlltkhmRVTVLgtfimlatytlFYIMTVYSMTFSTTPAAQGGLDFprNDVLWMLMMAVIGFgLMVPIAGLL 313
Cdd:cd17378 174 ---------------RLLAV-----------MVIGFGIGMVYYGIPLAVGNLKF--NIYLSVALNALSEL-PAFVITAFL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 314 ADRFGRRKSMIVITTLILLFALFVFppLLGSGSQTMV-MAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVS 392
Cdd:cd17378 225 LDRFGRRPSLLGFTLLSGASCLLCF--VLSIGGTTSLqIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGM-LRQA 301
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1126561678 393 SILGASVAPYIATWLQAN----YGLFYVGIYLAAMAALTL 428
Cdd:cd17378 302 LVVGGIFAPFIVSLGRKNaalsFGVFGVAILLLGLFALGL 341
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
148-432 |
6.33e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.00 E-value: 6.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 148 ALLATENAPAHKRALYG---SFPQLGAPIGFFFAngtFLLLSWLltdeqfmSWGWRVPFIFSAVLVLIGLYVRVSLHETP 224
Cdd:cd17370 111 ALLADATPPSGRGKAFGlhrALDTLGAVLGPLLA---ALLLYLL-------GGNYRTIFLLAAIPALLALLILLFVVKEY 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 225 VFAKiaKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYtlfyimtvYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVigFG 304
Cdd:cd17370 181 PRPP--KLRKKSKKTSLKKLPKAFWLYLLAVALFALGN--------FSFAFLILRAQELGLSAALIPLLYALFNLV--YA 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 305 LMVPIAGLLADRFGRRKsMIVITTLILLFALFVFppLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRYTG 384
Cdd:cd17370 249 LAAYPAGRLSDRIGRKK-LLILGYLSLALAYLGF--ALGSSLWLLLLGFILWGLY-MGAQESIERAAVADLVPAELRGTA 324
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1126561678 385 ASFSYNVSSIlGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd17370 325 YGLFNTVVGI-GWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
61-432 |
1.01e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 61 TAATLQSLATFAIAFVARPigsaVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGImaplLLALARFGQGLGL 140
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQP----LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL----LVALAGIGSAAFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 141 GGEWGGAALLATENapahkRALYGSFPQLGAPIGFFFANgtfLLLSWLLTDEQFMSWGWRVPFIFSAVLVLIGLYVRVSL 220
Cdd:cd17478 103 PEGARLASQAAGGR-----RGLAMSIFSVGGNLGFALGP---LIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 221 HETPVFAKIAKAKKQVKVPLGTLLtkhmRVTVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLdfprndVLWMLMMAV 300
Cdd:cd17478 175 PEAKKAAAKSSARSTLKGVWRALL----LLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLL------LSLFLFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 301 IGfglmVPIAGLLADRFGRRKsMIVITTLILLFALFVFPPLLGSGSqtmVMAYLLIGLSLMGlTFGPMGALLPELFPTEV 380
Cdd:cd17478 245 IG----TLIGGPLSDRFGRRR-VIIASLLLAAPFLLLFLLTPGIWS---YILLVLAGFLLFA-SFPVTVVLAQELLPGNV 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1126561678 381 RyTGASFSYNVSSILGAsVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd17478 316 G-LASGLMMGLSFGLGG-IGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
86-433 |
1.49e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 49.88 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 86 GHFGDRVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAALLATENAPAHKRALYGS 165
Cdd:cd17319 59 GWLLDRFGARKVLAVSMLLWSLFTALTGFATS--------LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 166 FPQLGAPIGFFFAngtFLLLSWLLTdeqfmSWGWRVPFIFSAVL-VLIGLYVRVslhetpvfakiakakkqvkvplgtll 244
Cdd:cd17319 131 LFNSGAPLGAAIG---PPLSGWLLL-----LFGWRWAFIIEGLLgLLLAVLWWF-------------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 245 tkhmrvtVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMI 324
Cdd:cd17319 177 -------YLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 325 VITTLILLFALFVFPPLLgSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFsYNVSSILGASVAPYIA 404
Cdd:cd17319 250 VIIIGLLLAAVGLLLAYL-TTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL-INSGGNLGGFVAPLLI 327
|
330 340 350
....*....|....*....|....*....|
gi 1126561678 405 TWL-QANYGLFYVGIYLAAMAALTLIALIA 433
Cdd:cd17319 328 GYLvDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
294-434 |
1.80e-06 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 49.81 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 294 WMLMMAVIGFGLMV--PIAGLLADRFGRRKSMI---VITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGltFGPM 368
Cdd:cd17337 246 WLQIWGIIFLVNIFfnLIFGILGDKIGWRRTVRwfgGVGCAISTLLFYYVPQLFGHNYWAALIAAILFGIGLAG--FVPL 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126561678 369 GALLPELFPTEvryTGASFS-YNVSSILGASVAPYIATWLqanYGLFYVGIYLAAMAALTLIALIAT 434
Cdd:cd17337 324 SALMPSLAPEH---KGAAMSiLNLGAGLSNFVGPAIVTLF---LGSFGAGGVVWIFAGLYLLSAVLT 384
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
75-434 |
1.87e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.88 E-value: 1.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 75 FVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESI----------GIMAPLLLALARfgqglglggew 144
Cdd:cd17504 41 LLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLiagralqgigGAVFPLAFALVR----------- 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 145 ggaALLATENAPAHKRALYGSFPqLGAPIGFFFAngtflllSWLLTDeqfmsWGWRVPFIFSAVLVLIGLYVrvslheTP 224
Cdd:cd17504 110 ---EEFPPERVPVAQGILSATFG-IGAGIGLPLG-------GWIVQH-----LGWRWIFWTAAPVAVLLAAL------VP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 225 VFAKIAKAKKQVKVPLGTLLtkhmrvtvlgtFIMLATYTLFYIMTVYSMtfstTPAAQGGLDFPRNDVLWMLMMAVIGFg 304
Cdd:cd17504 168 LIDLRLLRRRNVLLANITAL-----------LAGFGMFMVFQLLPQLLQ----LPTPTGFGLGITEAGLLLLPGALVML- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 305 LMVPIAGLLADRFGRRKSMIVITTLILLFALFVFppLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLpeLFPTEVRYTG 384
Cdd:cd17504 232 IAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA--LLHSSLWALVVALLLIGIG-LGLAFASLPNIV--VESVPPDRTG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1126561678 385 ASFSYN-VSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIAT 434
Cdd:cd17504 307 IATGMNtVLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGAYVLAFLIGA 357
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
82-434 |
2.74e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.16 E-value: 2.74e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 82 SAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHKRA 161
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 162 LYGSFPQLGAPIGFF--FANGTFLLLSWLltdeqfmswGWRVPFIFSAVL-VLIGLYVRVSLHETP-VFAKIAKAKKQVK 237
Cdd:cd17328 123 RALGVFYFAIPLGSGlgYVVGGLVAQATG---------GWRWAFRVTGVLgVLLAILLLLFVREPPrGAAEGGVMAKSTA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 238 VPLGTLLTKHMRV-----TVLGTFIM-LATYTL-FYIMTVYSMTFSTTPAAQGgldfprNDVLWMLMMAVIGFGLMVPIA 310
Cdd:cd17328 194 TSFLADLKALAKNpsfilSTLGFTAVsFVTGALaFWAPTFFLRAFGVGDLSSA------DVGLIFGAITCIAGVLGVLLG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 311 GLLADRFGRRKS-----MIVITTLILLFALFVFPPLlgsGSQTMVMAYLLIGLS--LMGLTFGPMGALLPELFPTEVRYT 383
Cdd:cd17328 268 GILADRLRRKTPradplVCAVGLLAAAPFLFLALVL---ALSNLLLAWVLLFLGefLLSLNWAPVFAILLYVVIPTRRST 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1126561678 384 GASFSYNVSSILGASVAPYIaTWLQANYGLFYVGIYLAAMAALTLIALIAT 434
Cdd:cd17328 345 ASAIQILLSHLLGDAGSPYL-IGLISDLLRQNKDSPLAEAASLQYALLLCS 394
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
60-388 |
3.10e-06 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 49.10 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 60 PTAATLQSLATfAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPgyeSIGIMaplllALARFGQGLG 139
Cdd:cd17359 32 NLTPFLEGLVV-SSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSP---NFTIF-----IIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 140 LGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQFMSWGWRVPF---IFSAVLVLIGLYV 216
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLgleAIPAILFLLGMLF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 217 rvsLHETPVFAkIAKAKKQVKVPLGtlltkhmrVTVLGTFIMLATyTLFYIMTVYSMTFSTTPAAqggldfprndvlwml 296
Cdd:cd17359 183 ---IPESPRWL-VSKGKPILIIGIG--------LAIFQQFVGINV-IFYYGPEIFQNAGFSENAA--------------- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 297 MMAVIGFG----LMVPIAGLLADRFGRRKSMIV-----ITTLILLFALFVFPPLLGSGSqTMVMAYLLIGLSLMGLTFGP 367
Cdd:cd17359 235 LLQTIGIGvvnvIFTIIAILLVDKVGRKPLLLIgsigmAISLLLIGTAFYFAPGSQASG-IVALVLILLFVAFFAMSWGP 313
|
330 340
....*....|....*....|..
gi 1126561678 368 -MGALLPELFPTEVRYTGASFS 388
Cdd:cd17359 314 vTWVLLSEIFPNRIRGLAMGIA 335
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
80-442 |
3.30e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 48.89 E-value: 3.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 80 IGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHK 159
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 160 RALYGSFPQLGAPIGfffangtflLLSWLLTDEQFMS--WGWRVPFIFSAVLVLIGLYVRVSLHETPVFakiakaKKQVK 237
Cdd:cd17362 126 RGLLVSLKELFIVLG---------ILLGYVSGYAFADvvGGWRYMYGLAAPPALLLGIGMWFLPPSPRW------QGNYR 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 238 VPLGTLLTKHMRVTVLGTfimlaTYTLFYIMTVY-SMTFSTTPAAQGgldfprndvlwmlmmAVIGFG----LMVPIAGL 312
Cdd:cd17362 191 KPLIIGLGLVLFQQITGQ-----PSVLYYAATIFkSAGFSAASDATL---------------VSVGLGvfklLMTIVAVL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 313 LADRFGRRKSMI-----VITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGAL-LPELFPTEVRYTGAS 386
Cdd:cd17362 251 LVDKLGRRPLLLggvsgMVVSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLmVSEIFPLRVRGRAIA 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1126561678 387 FSYNVSSILGASVAPYIATwLQANYGL--FYVGIYLAAMAALTLIALIATkETRHQSL 442
Cdd:cd17362 331 LAVLVNFGSNALVSLAFLP-LQELIGLpgTFLGFGVIGVLALLFIYFTVP-ETKGLSL 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
71-441 |
4.93e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.31 E-value: 4.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 71 FAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALL 150
Cdd:COG0738 49 LFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGLLDVAANPY 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 151 ATENAPAHKRALYGSFpqlgapiGFFFANGTF---LLLSWLLTDEqfMSWGWRVPFIFSAVLVLIgLYVRVSLHETPVFA 227
Cdd:COG0738 121 VAALGPETAASRLNLL-------HAFFSLGALlgpLLGGLLILLG--LSLSWHLPYLILAVLLLL-LALLFLRSKLPEIE 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 228 KIAKAKKQVKVPLGTLLtkHMRVTVLGTFIMlatytLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMV 307
Cdd:COG0738 191 EEEEEAAGSAASLKSLL--KNPRLLLGGLAI-----FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGR 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 308 PIAGLLADRFGRRKSMIVITTLILLFALFVfppLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRYTGASF 387
Cdd:COG0738 264 FLGGFLLKRFGPVRLLRLSALLAAVGLLLA---LLAPGPWLALIGLALVGLG-LSLMFPTIFSLALDGLGKRTAAAVSAV 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1126561678 388 SynVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIATKETRHQS 441
Cdd:COG0738 340 L--IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
263-432 |
1.08e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 263 TLFYIMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVittLILLFALFVFPPLL 342
Cdd:pfam07690 5 AFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI---GLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 343 GSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRYTGASFsYNVSSILGASVAPYIATWLQANYGLFYVGIYLAA 422
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLG-AGALFPAALALIADWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
|
170
....*....|
gi 1126561678 423 MAALTLIALI 432
Cdd:pfam07690 160 LSLLAAVLLL 169
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
49-429 |
1.87e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 46.50 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 49 VFPHIFFPQGDPTAATLQSLATfAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAplL 128
Cdd:cd17364 24 ILGRLYYGGKGSLPSGVSGLVN-AAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--W 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 129 LALARFGQGLGLGGEWGGAALLATENAPAHKR----ALYGSFPQLGAPIGFFFANGTFLLLSWLLTDEQF--MSWGWRVP 202
Cdd:cd17364 101 LIFFRFLLGIGIGGDYPLSATIMSEYANKKRRgaliAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGTYhhADLVWRIV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 203 FIFSAVLVLIGLYVRvslhetpvfakiakakkqvkvplgtlltKHMRVTVLGTFIM-LATYT--LFYIMTVYSMTFSTTP 279
Cdd:cd17364 181 LGLGAIPALSVLYFR----------------------------KHLLGTAGTWFLLdIAFYGqnLFQSTIISAIGFSKTM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 280 -AAQGGLdfpRNDVLWmLMMAVIGFGLMVPIAGLLADRFGRRKsMIVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGL 358
Cdd:cd17364 233 nAYQELF---NIAVGQ-LIIALAGTVPGYWFTVFLIDRIGRKK-IQMMGFFGMTIFLLILAGPYDHWKISTIGFFVLYGL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126561678 359 SLMGLTFGP--MGALLP-ELFPTEVRYTGASFSyNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLI 429
Cdd:cd17364 308 TFFFSNFGPntTTFIVPaEVFPARVRSTCHGIS-AASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGII 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
69-432 |
2.19e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 2.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 69 ATFAIAFVARPIGsavfGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAA 148
Cdd:cd17489 39 LFTLAALLARPFA----GRLLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 149 LLATENAPAHKRALYGSFPQLGAPIGFFFANGTFLLLswlltdeqFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVfak 228
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL--------YQHLGFAVLFIVAAVLALLALLLVFLVKDPPP--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 229 iAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLDFprndvlwmlMMAVIGFGLMVP 308
Cdd:cd17489 176 -VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF---------TVYAIALLLSRP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 309 IAGLLADRFGRRKsMIVITTLILLFALFVFppllgsgSQTMVMAYLLIGLSLMGLTFGPM----GALLPELFPTEVRyTG 384
Cdd:cd17489 246 FSGKLSDRKGPKT-VIIPGLLLLALGLLLL-------SFAGSPWMLLLAAVLYGLGFGLLfpalQALAVDLVPPHRR-GA 316
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1126561678 385 ASFSYNVSSILGASVAPYIATWLQANYGlfYVGIYLAAmAALTLIALI 432
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAELFG--YRAMFLLA-AVVVLLALV 361
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
61-429 |
5.54e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 45.30 E-value: 5.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 61 TAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGl 140
Cdd:PRK09874 50 SALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNAN- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 141 ggewggaALLATEnAPAHKRALYGSFPQLGAPIGFFFANgtflLLSWLLTDeqfmSWGWR-VPFIFSAVLVLIGLYVRVS 219
Cdd:PRK09874 129 -------ALIATQ-VPRNKSGWALGTLSTGGVSGALLGP----LAGGLLAD----SYGLRpVFFITASVLFLCFLVTLFC 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 220 LHE--TPVFAKIAKAKKQVKVPL-GTLLTKHMRVTVLgtFIMLATYTLFYIMTVYSMTFSttpAAQGGLDFPRNDVLWML 296
Cdd:PRK09874 193 IREnfQPVSKKEMLHMREVVTSLkNPKLVLSLFVTTL--IIQVATGSIAPILTLYVRELA---GNVSNIAFISGMIASVP 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 297 MMAVIgfgLMVPIAGLLADRFGRRKSMIV---ITTLILLFALFVFPPLlgsgsQTMVMAYLLIGLSlmgltfgpmGALLP 373
Cdd:PRK09874 268 GVAAL---LSAPRLGKLGDRIGPEKILITaliFSVLLLIPMSFVQTPL-----QLGILRFLLGAAD---------GALLP 330
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1126561678 374 E-----LFPTEVRYTGASFSYNVS-SILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLI 429
Cdd:PRK09874 331 AvqtllVYNSSNQIAGRIFSYNQSfRDIGNVTGPLMGAAISANYGFRAVFLVTAGVVLFNAV 392
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
147-416 |
1.41e-04 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 43.78 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 147 AALLATENAPAHKRALYGSFPQLGAPIGFFFANgtflLLSWLLtdEQFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVF 226
Cdd:cd17361 125 VPLYLSEMAPAKLRGALNIGFQLAITIGILIAN----LINYGT--SKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNS 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 227 AKIAKAkkqvkvplgtlltkhmrvTVLGTFIML--ATYTLFYIMTVY-SMTFSTTPAAQGGLdfprndvlwmLMMAVIGF 303
Cdd:cd17361 199 PQLVIA------------------ILIPFFQQLtgINVIMFYAPVLFqTLGFGSDASLISAV----------ITGAVNVV 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 304 GLMVPIagLLADRFGRRK-----------SMIVITtlILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALL 372
Cdd:cd17361 251 STLVSI--YLVDRFGRRFllleggvqmlaSQVAIG--ILLAVKFGDGGELPKAYAIAVVVLICLYVAAFAWSWGPLGWLV 326
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1126561678 373 P-ELFPTEVRYTGASFSYNVSSILGASVAPYIATWLQA-NYGLFYV 416
Cdd:cd17361 327 PsEIFPLETRSAGQSLTVAVNFLFTFVIAQAFLSMLCAmKFGIFLF 372
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
70-416 |
1.52e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.79 E-value: 1.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 70 TFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALARFGQGLGlggewggaAL 149
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNAT--------AL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 150 LATEnAPAHKRALYGSFPQLGAPIGFFFANgtflLLSWLLTDeqfmSWGWR-VPFIFSAVLVLIGLYVRVSLHE--TPVF 226
Cdd:cd17391 113 IASQ-TPKEKSGWALGTLSTGVVAGTLIGP----LLGGFLAD----LFGIRnVFFITGGLLFLAFLLTLFFVKEdfKPVE 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 227 AKIAKAKKQV--KVPLGTLLtkhMRVTVLGTFIMLATYTLFYIMTVYSMTFSTTpaaQGGLDFprndvLWMLMMAVIGFG 304
Cdd:cd17391 184 KKKMVSTKEVwnSVPNPSLL---ISLFVTTFIIQLANQSIEPILTLYIRQLMGD---ASNLAF-----ISGLVFSATGVS 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 305 LMV--PIAGLLADRFGRRKsmIVITTLILLFALFVFPPLLGSGSQtmvmayLLIGLSLMGLTFGPM----GALLPELFPT 378
Cdd:cd17391 253 SLLsaPRLGKLGDRIGHHR--ILLGALLASALLYIPQAFVQTPWQ------LGILRFLLGLATGGLlpaiNSLLAKITPK 324
|
330 340 350
....*....|....*....|....*....|....*....
gi 1126561678 379 EVryTGASFSYNVS-SILGASVAPYIATWLQANYGLFYV 416
Cdd:cd17391 325 EV--AGRIFGYNQSfQYLGNVAGPLLGSAIAAHFGYRAV 361
|
|
| 2A0121 |
TIGR00900 |
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds] |
296-431 |
2.54e-04 |
|
H+ Antiporter protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 162098 [Multi-domain] Cd Length: 365 Bit Score: 43.08 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 296 LMMAVIGFGLMVPIAGLLADRFGRRKsMIVITTLILLFALFVFPPLLGSGSQTMVMAYLLIG-LSLMGLTFGP-MGALLP 373
Cdd:TIGR00900 40 ALAGMLPYVVLSPIAGALADRYDRKK-VMIGADLIRAVLVAVLPFVALLGGLNIWQVYVLAGiLAIAQAFFTPaYQAMLP 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126561678 374 ELFPTEVRYTGASFS---YNVSSILGASVAPYIATWLQANYGLFYVGIyLAAMAALTLIAL 431
Cdd:TIGR00900 119 DLVPEEQLTQANSLSqavRSLFYIVGPGIGGLMYATLGIKWAIWVDAV-GFAISALLIVSV 178
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
294-433 |
3.51e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.55 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 294 WMLMMAVIGFGLMVPIAGLLADRFGRRKSmIVITTLILLFALFVFppLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLP 373
Cdd:COG2807 57 LLTTLPLLAFGLFAPLAPRLARRFGLERT-LLLALLLLAAGLLLR--SLAPSVALLLAGTALIGAG-IAVGNVLLPGLIK 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126561678 374 ELFPTEV-RYTGAsfsYNVSSILGASVAPYIATWLQANYGLfyvGIYLAAMAALTLIALIA 433
Cdd:COG2807 133 RWFPDRVgLMTGL---YTAAMGLGAALAAGLTVPLAAALGW---RGALAVWALLALLALLL 187
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
294-431 |
3.91e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.61 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 294 WMLMMAVIGfglmvPIAGLLADRFGRRkSMIVITTLillfaLFVFPPLLGSGSQTMVMayLLIGLSLMGLTFG---PMGA 370
Cdd:cd06179 41 WSLAQAVLG-----PIVGRLSDLFGRR-WFFIGGNL-----LGVVGSIVAGTAKSVNM--LIGGQALIGIGAGtqgLGAA 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1126561678 371 LLPELFPTEVRYTGASfSYNVSSILGASVAPYIATWLQANYG-----LFYVGIYLAAMAALTLIAL 431
Cdd:cd06179 108 VASELVPNKYRGLVQG-VVNLVASPGSALGPLIAGALVEANAagwrwIFYINAIFNALALILLFFF 172
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
69-431 |
4.14e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.16 E-value: 4.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 69 ATFAIAFVarpIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAA 148
Cdd:cd17477 38 SAYYLGIL---LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSE 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 149 LLATENAPAHKR----ALYGSFpqlgapIGFFFANGTfLLLSWLLTDEQFmswgwrvPFIFSAVLVLIGLyVRVSLhetp 224
Cdd:cd17477 107 SWLNALATNENRgrvlGLYSTV------LGLGFALGP-LLLALVGTAGAL-------PFLIAAVLLLLAL-VPLLL---- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 225 VFAKIAKAKKQVKVPLGTLLTKhMRVTVLGTFIMLATYTLFY-IMTVYSMtfsttpaaqgGLDFPRNDVLWMLMMAVIGF 303
Cdd:cd17477 168 TRRAAPEIEEAESISLRRLLRI-APLALLGAFVAGFLEGAFYsLLPLYGL----------RLGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 304 GLMVPIAGLLADRFGRRKSMIVITTLILLFALFVfpPLLGSGSQTMVMAYLLIGLSLMGLtFGPMGALLPELFPtEVRYT 383
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLGCALLGALAALLL--PLVPGLPLALLVLLFLWGGAAGPL-YTLALALAGDRLP-GDELV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1126561678 384 GASFSYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIAL 431
Cdd:cd17477 313 AANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
267-434 |
4.35e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.27 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 267 IMTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVittLILLFALFVFPPLLGSGS 346
Cdd:COG2814 22 SGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL---GLLLFALGSLLCALAPSL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 347 QTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVRytGASFSYNVSSI-LGASVAPYIATWLQANYGLFYVGIYLAAMAA 425
Cdd:COG2814 99 WLLLAARFLQGLG-AGALFPAALALIADLVPPERR--GRALGLLGAGLgLGPALGPLLGGLLADLFGWRWVFLVNAVLAL 175
|
....*....
gi 1126561678 426 LTLIALIAT 434
Cdd:COG2814 176 LALLLLLRL 184
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
80-433 |
5.67e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 80 IGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHK 159
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--------ALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 160 R----ALYGSFPQLGAPIgfffangtFLLLSWLLTDeqfmsWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAKIAKAKKQ 235
Cdd:cd17473 122 RakmlGLQSAAMSLGGVV--------FLLLGGALAE-----IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 236 VKVPlgtllTKHMRVTVLGTFIMLATYTLFYIMTVY-----SMTFSTTPAAQGgldfprndvlwmLMMAVigFGLMVPIA 310
Cdd:cd17473 189 ATAA-----ALPWKRVLPIYFLAFLAMLLFYVIPIQlpfllQERGGGSAALIG------------LALAI--ASLAGAIG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 311 GLLADRFGRRKSmiVITTLILLFALFVFPPLLGSGSQTMVMayLLIGLSLMGLTFGPMG----ALLPELFPTEVRytGAS 386
Cdd:cd17473 250 ALLFGRLKRRLG--KRRLLAIGFALMALGFLLLALASGLWV--VLLGAILAGLGFGLLLptlnSWAMSLVPPELR--GRA 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1126561678 387 FSYNVSSI-LGASVAPYIATWLQANYGlFYVGIYLAAMAALTLIALIA 433
Cdd:cd17473 324 MGIVTSAFfLGQFLSPLVLGPLVNLTG-GLSGAFLILGVLALVLAIVL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
255-433 |
6.21e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.76 E-value: 6.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 255 TFIMLATYTLFYIM-TVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVittLILLF 333
Cdd:COG0738 7 RRALIAIYLLFFLWgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL---GLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 334 ALFVFPPLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTEVR----YTGASFSynvssiLGASVAPYIATWL-Q 408
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLG-LGLLDVAANPYVAALGPETAAsrlnLLHAFFS------LGALLGPLLGGLLiL 156
|
170 180
....*....|....*....|....*
gi 1126561678 409 ANYGLFYVGIYLAAMAALTLIALIA 433
Cdd:COG0738 157 LGLSLSWHLPYLILAVLLLLLALLF 181
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-432 |
7.15e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 7.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 84 VFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGyesigimaPLLLALARFGQGLGLGGEWGGAALLATENAPAHKR--- 160
Cdd:cd17321 50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgra 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 161 -ALYGSFPQLGAPIGFFFANgtfLLLSWLltdeqfmswGWRVPFIFSAVLVLIGLYVrvslheTPVFAkiakakkqvkvp 239
Cdd:cd17321 122 lGLWGAVVGIGAALGPLLGG---LLLELF---------GWRWIFLINVPIGLVALLL------ARTFS------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 240 lgtlltkhmRVTVLGTFIMLATYTLFYIMTVYsmtfsttpaAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGR 319
Cdd:cd17321 172 ---------GAVLAAFLLGAALGGLLFLLPLY---------LQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 320 RKSMI---VITTLILLFALFVFPPllgSGSQTMVMAYLLIGLSlMGLTFGPMGALLPELFPTE-----------VRYTGA 385
Cdd:cd17321 234 RLVLVaglLLTAVGLLLLALLGAD---SSVWLLLPGLVLLGLG-LGLFATPLTNAALSSVPKEkagaasgilntARQLGG 309
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1126561678 386 SFSYNVS-SILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd17321 310 ALGVALLgALLTAGLSANLGDSGVAALLSAAAAAFAAGFHLAFLVAAA 357
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
80-431 |
8.79e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.45 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 80 IGSAVFGHFGDRVGRKVTLVASLLTMGIStvvigllpgyesigimaplLLALARFGQGLGLGGEWGGAALLATENAPAHK 159
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAA-------------------ALLMALVGSYPVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 160 RALYGSFP-----------QLGAPIGFFFANGTFLLLswlltdeqFMSWGWRVPFIFSAVLVLIGLYVRVSLHETPVFAK 228
Cdd:cd17475 107 RAIMRWFPprerglamgirQTGVPLGGALAAALLPPL--------ALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 229 IAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATyTLFYIMTVYSMTFSTTpaaqgGLDFPRNDVLWMLMMAVIGFGLMVP 308
Cdd:cd17475 179 AATESASTLLRSLKEVLRNRDVWLIAIAGALLV-APQFALLTFLLLFLHD-----HLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 309 IAGLLADRF--GRRKSMIVITTLI--LLFALFVFPPlLGSGSQTMVMAYLLIGLSLMGLtFGPMGALLPELFPTEVRYTG 384
Cdd:cd17475 253 GLGRVSDRVfgGRRRPVLVITAAIaaAALLVLSLLS-PGTPLWLLVLLLILLGLFAIGW-NGLYLTLVAESAGPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1126561678 385 ASFSyNVSSILGASVAPYIATWLQANYGLFYVG-IYLAAMAALTLIAL 431
Cdd:cd17475 331 LGLA-NTINFIGIAIGPPLFGLLVDATHSYAPAwLALALLLVLAALLL 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-432 |
9.81e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.06 E-value: 9.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 61 TAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYESIGIMAPLLLALAR-FGQGLG 139
Cdd:cd06173 30 TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLgIASAFF 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 140 LGGEWGGAALLATENAPAHKRALYGSFPQLGAPIGFFFANgtfLLLSWLltdeqfmswGWRVPFIFSAVLVLIGLYVRVS 219
Cdd:cd06173 110 GPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGG---LLVALL---------GPGGAFAINALSFLLSALLLLF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 220 LHETPVFAKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLATYTLFYIMtvysMTFSTTPAAQGGLDFPrnDVLWMLMMA 299
Cdd:cd06173 178 IRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGA----LTVLLPLLAKEVLGGG--AAGYGLLLA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 300 VIGFGLMvpIAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTE 379
Cdd:cd06173 252 AFGVGAL--LGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1126561678 380 VRYTGASFsYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd06173 330 LRGRVFSV-YNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
60-432 |
9.93e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 9.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 60 PTAATLQSLATFAIAFVarpIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYEsigimaplLLALARFGQGLG 139
Cdd:cd17320 32 SASAVQLTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 140 LGGEWGGAALLATENAPAHKRALYGSFpqLGAPIGFFFANGTfLLLSWLLtdeqfMSWGWRVPFIFSAVL-VLIGLYVRV 218
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSL--LMMILAIAPALAP-LLGGLLL-----LFFGWRAIFVFLALLgLLLLLLVLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 219 SLHETPVFAKIAKAKKQVKVPLGTLLTkhMRVTVLGTFIMLATYTLFYImtvysmTFSTTPA-AQGGLDFPRNDVLWMLM 297
Cdd:cd17320 173 FLPETLPEEKRKPLLSSLLRAYKRVLK--NRRFLGYALALGLSFAGLFA------YLAAAPFiYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 298 MAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALFVFP-PLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELF 376
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLaALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1126561678 377 PtEVRYTGASFsYNVSSILGASVAPYIATWLqANYGLFYVGIYLAAMAALTLIALI 432
Cdd:cd17320 325 P-HVAGTASAL-LGFLQFLIGALAGALVGLL-PNGTALPMGLLILVLGLLALLLLI 377
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
296-428 |
1.04e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 296 LMMAVIGFGLMVPIAGLLADRFGRRKSMIVITTLILLFALfvfpPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPEL 375
Cdd:cd17372 235 VFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLL----LLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEV 310
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1126561678 376 FPTEVRYTGASFSYNVSSIlGASVAPYIATWLQANY-----GLFYVGIYLAAMAALTL 428
Cdd:cd17372 311 YPTAVRALGVGTGSSVGRI-GAILCPFIAQVLVHGSqtialLLFSVVCLVSAICVCLL 367
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
80-434 |
1.24e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 80 IGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPaHK 159
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--------ALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 160 RALYGSFPQLGAPIGFFFANGTFLLLSwlltdeqfMSWGWRVPFIFSAVLVLIGLYV-RVSLHETPVFAKIAKAKKQVKV 238
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPLA--------AALGWRGALAVWALLALLALLLwLPLLRRRPAAAAAAPAAASLRS 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 239 PLGTLLTkhMRVTVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQGGLdfprndVLWMLMMAVIGfglmVPIAGLLADRFG 318
Cdd:COG2807 211 LWRSPLA--WLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL------LSLFQLAGIPG----SLLVPLLADRLG 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 319 RRKSMIVITTLILLFALFVFppLLGSGSQTMVMAyLLIGLSLmGLTFGPMGALLPELFPTEVRYTGASFSYNVSSILGAS 398
Cdd:COG2807 279 DRRPLLLLLGLLGLAGLLGL--LLAPGSLPWLWA-VLLGLGQ-GGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAA 354
|
330 340 350
....*....|....*....|....*....|....*.
gi 1126561678 399 VAPYIATWLQANYGLFYVGiyLAAMAALTLIALIAT 434
Cdd:COG2807 355 LGPLLVGALHDATGSWTAA--LLLLAALAVLMLVAG 388
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
293-429 |
1.24e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.19 E-value: 1.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 293 LWMLMMAVigfglMVPIAGLLADRFGRRKSMIVITTLILLFALFvfppllgsGSQTMVMAYLLIGLSLMGLTFGPMGA-- 370
Cdd:pfam06609 86 LWTMGQAV-----SILMMGRLTDRFGRRPFVIATHIIGLVGAIV--------GCTANKFNTLLAAMTLLGVAAGPAGAsp 152
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126561678 371 -LLPELFPTEVRYTGAsFSYNVSSILGASVAPYIATWL--QANYG-LFYVGIYLAAMAALTLI 429
Cdd:pfam06609 153 lFIGELMSNKTKFLGL-LIVSAPTIAMNGAGPYFGQRLaiQGNWRwIFYIYIIMSAIAVLLII 214
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
79-403 |
1.35e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 40.74 E-value: 1.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 79 PIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGLLPGYesigimapLLLALARFGQGLGLGGEWGGAALLATENAPAH 158
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF--------PVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 159 KRALYGSFPQLGAPIGFFFANGtfllLSWLLTDEQFMSWGWRVPFIFSAVLVLIglyvrvslhetpvfakiakakkqvkV 238
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAG----LAYAIRDWRLLQLVVSVPFFLFFLYSWW-------------------------L 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 239 PLGTLLTKHMRVTVLGTFimlatYTLFYIMTVYSMTFSTTPAAQGGLDFPRNdvlwmlmmavigfglmvPIAGLLADRFG 318
Cdd:cd17374 172 PKRTLILSFVWFANSFSY-----YGLSLDLQHLGLNVFLLQFLFGAVEVPAR-----------------CLALFLLNHMG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 319 RRKSMIVITTLILLFALFVfpPLLGSGSQTMVMAYLLIGLSLMGLTFGPMGALLPELFPTEVRYTGASFSyNVSSILGAS 398
Cdd:cd17374 230 RRISQAVLLLLAGLCILAN--IFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLN-SMFARIGGI 306
|
....*
gi 1126561678 399 VAPYI 403
Cdd:cd17374 307 LAPLI 311
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
295-438 |
1.71e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.69 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 295 MLMMAVIGFgLMVPIAGLLADR----FGRRKSMIVITTLILLFALFVFP------PLLGSGSQTMVMAYLLIGLSLMGL- 363
Cdd:cd17313 40 WTLGPILGL-FVQPLVGSLSDRcnsrIGRRRPFILVGAPLAALGLILIPnaadigLALGDGPRTWALVLFVLGIVLLDFa 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 364 ---TFGPMGALLPELFPTEVRYTG---ASFSYNVSSILGASV--APYIATWLQANYGLFYVGIYLAA---MAALTLIALI 432
Cdd:cd17313 119 mnvCQGPVRALLPDLVPPEQRSKAngiINFMGGLGGVLGYLLgaILWDHNWFGFALGGNLKVPFYIGaiiLLVCVLVTLF 198
|
....*.
gi 1126561678 433 ATKETR 438
Cdd:cd17313 199 FVKEPP 204
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
36-127 |
1.93e-03 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 40.48 E-value: 1.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 36 FFDFY-IYATAAVIVFPHIFFPQGDPTAATLQSLATFAIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTMGISTVVIGL 114
Cdd:TIGR00887 26 FTDSYdLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGL 105
|
90
....*....|...
gi 1126561678 115 LPGYESIGIMAPL 127
Cdd:TIGR00887 106 SPGSSPKSVMATL 118
|
|
| MFS_GLUT_Class1 |
cd17431 |
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
291-381 |
2.85e-03 |
|
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340989 [Multi-domain] Cd Length: 445 Bit Score: 40.01 E-value: 2.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 291 DVLWMLMMAVIGFGLMVP--IAGLLADRFGRRKSMIVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSlMGLTFGPM 368
Cdd:cd17431 49 TTLWSLSVAIFSVGGMIGsfSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLSKLAKSYEMLILGRFIIGLY-CGLTTGLV 127
|
90
....*....|...
gi 1126561678 369 GALLPELFPTEVR 381
Cdd:cd17431 128 PMYIGEISPTALR 140
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
72-442 |
3.09e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 39.87 E-value: 3.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 72 AIAFVARPIGSAVFGHFGDRVGRKVTLVASLLTmgistVVIGLLPGYESIGIMaplLLALARFGQGLGLGGEWGGAALLA 151
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIP-----CILGWLLIAFAKDVW---MLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 152 TENAPAHKRALYGSFPQLGAPIG--FFFANGTFLllswlltdeqfmswGWRVPFIFSAVLVLIGLYVRVSLHETPVF--- 226
Cdd:cd17358 120 AEIAPKNVRGALGSLNQLLVNIGilLGYVLGSFL--------------PWRTLALIGAIPPVVFLILLFFIPESPRWlak 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 227 ---------------------------AKIAKAKKQVKVPLGTLLTKHMRVTVLGTFIMLAtYTLFYIMT-VYSMTF-ST 277
Cdd:cd17358 186 kgreeeaekslqflrgkdadiskeaaeIQEELAELEKEAKESSFSDLFQRKYLKPLVIGLG-LMLFQQLSgINAVIFyAS 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 278 TPAAQGGLDFPRNDVlwMLMMAVIGFgLMVPIAGLLADRFGRRKSMIVITT-----LILLFALFVFPPLLGSGSQTMVMA 352
Cdd:cd17358 265 SIFDEAGSGLDPNTA--TIIIGVVQV-VGTLVATLLVDRLGRRPLLLVSAIgmgigLLALGLYFYLQEHGALLSSVSWLP 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 353 YLLIGLSLMGLTFGpMGAL----LPELFPTEVRYTGASFSyNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTL 428
Cdd:cd17358 342 LVGLVIYIISFSIG-LGPLpwviMSEIFPAKIKGLAGSLV-TLVNWLFAFIVTKTFPFLTLAWGASGTFWIFAGICGLAL 419
|
410
....*....|....*
gi 1126561678 429 I-ALIATKETRHQSL 442
Cdd:cd17358 420 VfVLLFVPETKGKSL 434
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
200-433 |
3.23e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.53 E-value: 3.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 200 RVPFIFSAVLVLIG-LYVRVSLHETP---VFAKIAKAKKQVKVPLGTLLT-----KHMR---VTVLGTFIMLATYTLFYI 267
Cdd:cd17313 179 KVPFYIGAIILLVCvLVTLFFVKEPPlspEAGEHSENPSLGEVLKSLLKLlkimpRSLLrllLVIFFWWIAFFPFELFFT 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 268 MTVYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKsmIVITTLILLFALFVFPPLLGSGSQ 347
Cdd:cd17313 259 DYMGEEVYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKK--VYLIGLVLFAVGMALMALVHNVTV 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 348 TMVMAyLLIGLSLMGLTFGPMgALLPELFPTEVRYTGASFS-YNVSSILGASVAPYIATWLQAnygLFYVGIYLAAMAAL 426
Cdd:cd17313 337 ALVLF-ALGGIGWATININPY-PLVSDYHSESGRGQGTDTGlLNLAISLAQILVSLLAGPIID---VKGYGTVFPVAAVA 411
|
....*..
gi 1126561678 427 TLIALIA 433
Cdd:cd17313 412 SFLSLVG 418
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
308-433 |
3.57e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 39.52 E-value: 3.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 308 PIAGLLADRFGRRKSMIVItTLILLFALFVFPPLlgsgsqTMVMAYLLIGLSLMGLTFGPMGALLP----ELFPTevRYT 383
Cdd:cd17353 267 PFWGWLSDKIGRKNTLSIA-FLIQGVAMFLLPFI------GSVAVLFVLGVALIGFCYGGGFALFPaltaDFFGT--KNA 337
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1126561678 384 GASFSYNVSS-ILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIALIA 433
Cdd:cd17353 338 GTNYGLLYTAkGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
270-441 |
4.42e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 270 VYSMTFSTTPAAQGGLDFPRNDVLWMLMMAVIGFGLMVPIAGLLADRFGRRKSMIvitTLILLFALFVFPPLLGSGSQTM 349
Cdd:cd06174 11 ARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLL---LGLLLFALGALLFAFAPSFWLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 350 VMAYLLIGLSLmGLTFGPMGALLPELFPTEVRyTGASFSYNVSSILGASVAPYIATWL--QANYGLFYVGIYLAAMAALT 427
Cdd:cd06174 88 LLGRFLLGLGS-GLIDPAVLALIADLFPERER-GRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLA 165
|
170
....*....|....
gi 1126561678 428 LIALIATKETRHQS 441
Cdd:cd06174 166 AILLLLVVPDPPES 179
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
85-429 |
4.59e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 39.12 E-value: 4.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 85 FGHFGDRVGRKVTLVaslltMGISTVVIGLLPGYESIGIMaplLLALARFGQGLGLGGEWGGAalLATENAPAHKRALyg 164
Cdd:cd17472 52 FGLLSDRIGRKPVIL-----FGLLLFIAGSLLAAYATSIY---GLILGRALQGSGAISSVVMA--LLADLTREENRTK-- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 165 SFPQLGAPIGFFFANGtfLLLSWLLTDeqfmSWGWRVPFIFSAVLVLIGLYV--RVSLHETPVFAKIAKAKKQVKvplGT 242
Cdd:cd17472 120 AMALIGASIGIAFAIS--MVLGPLLAA----HLGVSGLFLITAILSLVSLLIllFFVPDPPKIVQISEKEKKKLK---KL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 243 LLTKHMRVTVLGTFIMLATYTLFYIMTVYSMTFSTTPAAQggldfprndvLWMLMMAVI--GFGLMVPiAGLLADRFGRR 320
Cdd:cd17472 191 LKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQ----------LWKVYLPAIliGFILMVP-FVIYAEKKGKM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 321 KSMIVITTLILLFALFVFppLLGSGSQTMvmayLLIGLSLMGLTFGPMGALLPELFPTEVR--YTGASFS-YNVSSILGA 397
Cdd:cd17472 260 KQVFVSSILLIAVGFLLL--LFAATSLWL----LIIGLIIFFIGFNLLEALLPSLVSKIAPkeYRGTAMGiYNTSQFLGS 333
|
330 340 350
....*....|....*....|....*....|..
gi 1126561678 398 SVAPYIATWLQANYGLFYVGIYLAAMAALTLI 429
Cdd:cd17472 334 FLGGALGGLLWGLLGYSSVFLTILILALLWLL 365
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
301-430 |
6.08e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.71 E-value: 6.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 301 IGFGLMVPIAGLLADRFGRRKsmiVITTLILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLtFGPMGALLPELFPTEV 380
Cdd:cd17319 49 LGYALFQVPGGWLLDRFGARK---VLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGF-FPGAIKALAEWFPARE 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1126561678 381 RYTGASFsYNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLIA 430
Cdd:cd17319 125 RGRATGL-FNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVL 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
294-429 |
8.87e-03 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 38.11 E-value: 8.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 294 WMLMMAVIGFGLMVPIAGLLADRFGRRKSMIVIttlILLFALFVFPPLLGSGSQTMVMAYLLIGLSLMGLtFGPMGALLP 373
Cdd:TIGR00895 56 FLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS---ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL-MPNLNALVS 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1126561678 374 ELFPTEVRYTGASfSYNVSSILGASVAPYIATWLQANYG---LFYVGIYLAAMAALTLI 429
Cdd:TIGR00895 132 EYAPKRFRGTAVG-LMFCGYPIGAAVGGFLAGWLIPVFGwrsLFYVGGIAPLLLLLLLM 189
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
255-426 |
9.10e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 255 TFIMLAtYTLFYIMTVYSMTFSTTPAAQGGLDFPRNDVlwMLMMAVIGFG--LMVPIAGLLADRFGRRKSMIVITTLILL 332
Cdd:cd17352 184 TFVLLA-LGVSFAMLGFFVPFVYLPSYAKSLGIDESDA--AFLLSIIGISdiVGRILLGLLADKPRIGRLYLYIFTLLIL 260
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 333 FALFVFPPLLGSGSQTMVMAyLLIGLSlMGLTFGPMGALLPELFPTEvRYTGASFSYNVSSILGASVAPYIATWLQANYG 412
Cdd:cd17352 261 GLSLLAFPLATTYVGLIVFS-VLFGFC-SGSYSSLTPVILADLVGLE-KLSNAYGLVLLFQGLAALVGPPIAGLLRDYTG 337
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170
....*....|....
gi 1126561678 413 LFYVGIYLAAMAAL 426
Cdd:cd17352 338 DYDAAFYFCGACLL 351
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| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
294-441 |
9.65e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 37.94 E-value: 9.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 294 WMLMMAVIGFGLMVPIAGLLADRFGRRKsMIVITTLILLFALFVFppLLGSGSQTMVMAYLLIGLSlMGLTFGPMGALLP 373
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKR-LLLLGLLLLAVSTLLF--AFATSYWQLLLARFLQGLA-SAAVWPAAMALIA 110
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90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126561678 374 ELFPTEVRytGASFS-YNVSSILGASVAPYIATWLQANYGLFYVGIYLAAMAALTLI-ALIATKETRHQS 441
Cdd:cd17325 111 DIAPPEER--GRAMGiFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVlALLLLPEPRPPP 178
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