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Conserved domains on  [gi|1128945374|ref|WP_075312333|]
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MULTISPECIES: methionine gamma-lyase family protein [Bacillus cereus group]

Protein Classification

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme( domain architecture ID 10008287)

aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme is a PLP-dependent carbon-sulfur lyase that may be involved in methionine catabolism or in conferring resistance to aluminum

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 9-417 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


:

Pssm-ID: 443276  Cd Length: 409  Bit Score: 830.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374   9 EKIAPIVKEVESQITEVHKRADEVIESNQFRVLESFRKHKISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRPQ 88
Cdd:COG4100     1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  89 IISGTHAISTALFGVLRPGDELLYITGKPYDTLEEIVGVRGKGVGSFKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKM 168
Cdd:COG4100    81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEDGKIDLEAIKKAINEKTKM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 169 IGIQRSKGYATRPSFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVG 248
Cdd:COG4100   161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 249 KEQYVEACAYRLTSPGIGAEAGASLYSLQEMYQGFFLAPHVAGQALKGAIFTAAFLEKLGMNTSPAWNAPRTDLIQSVQF 328
Cdd:COG4100   241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 329 DDKDRMIAFCQAIQYASPINSHFTPYANYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKIAIC 408
Cdd:COG4100   321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                  ....*....
gi 1128945374 409 SAIDALIEK 417
Cdd:COG4100   401 SALQALLEK 409
 
Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 9-417 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 830.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374   9 EKIAPIVKEVESQITEVHKRADEVIESNQFRVLESFRKHKISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRPQ 88
Cdd:COG4100     1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  89 IISGTHAISTALFGVLRPGDELLYITGKPYDTLEEIVGVRGKGVGSFKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKM 168
Cdd:COG4100    81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEDGKIDLEAIKKAINEKTKM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 169 IGIQRSKGYATRPSFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVG 248
Cdd:COG4100   161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 249 KEQYVEACAYRLTSPGIGAEAGASLYSLQEMYQGFFLAPHVAGQALKGAIFTAAFLEKLGMNTSPAWNAPRTDLIQSVQF 328
Cdd:COG4100   241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 329 DDKDRMIAFCQAIQYASPINSHFTPYANYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKIAIC 408
Cdd:COG4100   321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                  ....*....
gi 1128945374 409 SAIDALIEK 417
Cdd:COG4100   401 SALQALLEK 409
Met_gamma_lyase pfam06838
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ...
 15-415 0e+00

Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.


Pssm-ID: 429146  Cd Length: 405  Bit Score: 761.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  15 VKEVESQITEVHKRADEVIESNQFRVLESFRKHKISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRPQIISGTH 94
Cdd:pfam06838   5 YEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFVSGTH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  95 AISTALFGVLRPGDELLYITGKPYDTLEEIVGVRGKGVGSFKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKMIGIQRS 174
Cdd:pfam06838  85 AIATALFGVLRPGDELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEDGKVDWEAIKTAITPKTKLILIQRS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 175 KGYATRPSFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEQYVE 254
Cdd:pfam06838 165 KGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIAGKADLVE 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 255 ACAYRLTSPGIGAEAGASLYSLQEMYQGFFLAPHVAGQALKGAIFTAAFLEKLGMNTSPAWNAPRTDLIQSVQFDDKDRM 334
Cdd:pfam06838 245 QASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVKFGDKEKL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 335 IAFCQAIQYASPINSHFTPYANYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKIAICSAIDAL 414
Cdd:pfam06838 325 IAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAVLIALDAI 404


                  .
gi 1128945374 415 I 415
Cdd:pfam06838 405 V 405
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 59-296 5.54e-08

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 54.42  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  59 GYGYDDIGRDT---LEKVYADVFGAEAGLVrpqIISGTHAISTALFGVLRPGDELlyitgkpydtleeIVGVRGKGVG-S 134
Cdd:PRK07503   56 GHFYSRISNPTlalLEQRMASLEGGEAAVA---LASGMGAITATLWTLLRPGDEV-------------IVDQTLYGCTfA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 135 FKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKMIgiqrskgYATRPSFTISQIKEmIAFVKEI--KPDVVVFVDNCYGE 212
Cdd:PRK07503  120 FLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMV-------YFETPANPNMRLVD-IAAVAEIahGAGAKVVVDNTYCT 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 213 FIeEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEQYVEAcayrltspgigaeagASLYSLQEMyQGFFLAPHVAGQ 292
Cdd:PRK07503  192 PY-LQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADR---------------IRLEGLKDM-TGAVMSPFDAFL 254


                  ....
gi 1128945374 293 ALKG 296
Cdd:PRK07503  255 LMRG 258
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 67-296 3.23e-07

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 51.82  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  67 RDTLEKVYADVFGAEAGLVRPqiiSGTHAISTALFGVLRPGDELL---YITGKPYDTLEEIvgvrgkgvgsFKEYNIgyn 143
Cdd:cd00614    42 VDALEKKLAALEGGEAALAFS---SGMAAISTVLLALLKAGDHVVasdDLYGGTYRLFERL----------LPKLGI--- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 144 avpltEEGFVDFG---AVATAIHSNTKMIgiqrskgYA---TRPSFTISQIKEMIAFVKEIkpDVVVFVDNCYGEFIeEQ 217
Cdd:cd00614   106 -----EVTFVDPDdpeALEAAIKPETKLV-------YVespTNPTLKVVDIEAIAELAHEH--GALLVVDNTFATPY-LQ 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1128945374 218 EPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEqyvEACAYRLTspgigaeagaslysLQEMYQGFFLAPHVAGQALKG 296
Cdd:cd00614   171 RPLELGADIVVHSATKYIGGHSDVIAGVVVGSG---EALIQRLR--------------FLRLALGTILSPFDAWLLLRG 232
 
Name Accession Description Interval E-value
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 9-417 0e+00

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 830.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374   9 EKIAPIVKEVESQITEVHKRADEVIESNQFRVLESFRKHKISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRPQ 88
Cdd:COG4100     1 EEILELVEEAEEELAPVFKEIDEIAEYNQLKVLKAFQKNRVSDSHFAGTTGYGYDDIGRDTLERVYADVFGAEDALVRPQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  89 IISGTHAISTALFGVLRPGDELLYITGKPYDTLEEIVGVRGKGVGSFKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKM 168
Cdd:COG4100    81 IVSGTHAIALALFGVLRPGDELLSITGKPYDTLEEVIGIRGEGQGSLKEFGISYRQVPLTEDGKIDLEAIKKAINEKTKM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 169 IGIQRSKGYATRPSFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVG 248
Cdd:COG4100   161 VLIQRSRGYSWRPSLTIEEIGEIIKFVKSINPDVICFVDNCYGEFVETREPTEVGADLMAGSLIKNPGGGLAPTGGYIAG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 249 KEQYVEACAYRLTSPGIGAEAGASLYSLQEMYQGFFLAPHVAGQALKGAIFTAAFLEKLGMNTSPAWNAPRTDLIQSVQF 328
Cdd:COG4100   241 RKDLVELAAYRLTAPGIGKEVGATLGQNRLMYQGLFLAPHVVGEALKGAIFAAAVFEKLGFEVSPKPDEPRSDIIQAIKL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 329 DDKDRMIAFCQAIQYASPINSHFTPYANYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKIAIC 408
Cdd:COG4100   321 GSPEKLIAFCQGIQKASPVDSHVTPEPWDMPGYEDPVIMAAGTFIQGSSIELSADGPIREPYIVYLQGGLTYEHVKLAIL 400


                  ....*....
gi 1128945374 409 SAIDALIEK 417
Cdd:COG4100   401 SALQALLEK 409
Met_gamma_lyase pfam06838
Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine ...
 15-415 0e+00

Methionine gamma-lyase; This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.


Pssm-ID: 429146  Cd Length: 405  Bit Score: 761.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  15 VKEVESQITEVHKRADEVIESNQFRVLESFRKHKISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRPQIISGTH 94
Cdd:pfam06838   5 YEQAENDILPIFKKIDEIVEFNQLKVLNAFQEERVSDHHFTGSTGYGYDDIGRDTLDRVYARVFGAEAALVRPQFVSGTH 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  95 AISTALFGVLRPGDELLYITGKPYDTLEEIVGVRGKGVGSFKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKMIGIQRS 174
Cdd:pfam06838  85 AIATALFGVLRPGDELLYITGSPYDTLEEVIGIRGEGQGSLKDFGIGYREVPLLEDGKVDWEAIKTAITPKTKLILIQRS 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 175 KGYATRPSFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEQYVE 254
Cdd:pfam06838 165 KGYSWRPSLTIAEIKEIIKFVKEINPDVIVFVDNCYGEFVETKEPTHVGADLIAGSLIKNPGGGIAPTGGYIAGKADLVE 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 255 ACAYRLTSPGIGAEAGASLYSLQEMYQGFFLAPHVAGQALKGAIFTAAFLEKLGMNTSPAWNAPRTDLIQSVQFDDKDRM 334
Cdd:pfam06838 245 QASYRLTAPGIGREGGATFGSLRLMYQGLFLAPHVVGEALKGAHLTARVLELLGFEVLPKYNEKRTDLIQAVKFGDKEKL 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 335 IAFCQAIQYASPINSHFTPYANYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYVAYVQGGLTYSHVKIAICSAIDAL 414
Cdd:pfam06838 325 IAFCQAIQAASPIDSHVDPEPADMPGYEDDVIMAAGTFIQGSSIELSADGPIREPYIAYVQGGLTYEHVKIAVLIALDAI 404


                  .
gi 1128945374 415 I 415
Cdd:pfam06838 405 V 405
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 67-253 4.87e-09

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 57.75  E-value: 4.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  67 RDTLEKVYADVFGAEAGLVRPqiiSGTHAISTALFGVLRPGDELL-----YitGKPYDTLEEIvgvrgkgvgsFKEYNIG 141
Cdd:COG0626    60 RRALEEALAALEGGEAALAFA---SGMAAISAVLLALLKAGDHVVasddlY--GGTRRLLDKV----------LARFGIE 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 142 YNAVPLTeegfvDFGAVATAIHSNTKMIgiqrskgYA---TRPSFTISQIKEMIAFVKEIkpDVVVFVDNC----YGefi 214
Cdd:COG0626   125 VTFVDPT-----DLAAVEAAIRPNTKLV-------FLetpSNPTLEVVDIAAIAAIAHAA--GALLVVDNTfatpLL--- 187

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1128945374 215 eeQEPCHVGADLMAGSLIKNPGG-GIVkTGGYIVGKEQYV 253
Cdd:COG0626   188 --QRPLELGADIVVHSATKYLGGhSDV-LGGAVVGRDEEL 224
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 59-296 5.54e-08

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 54.42  E-value: 5.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  59 GYGYDDIGRDT---LEKVYADVFGAEAGLVrpqIISGTHAISTALFGVLRPGDELlyitgkpydtleeIVGVRGKGVG-S 134
Cdd:PRK07503   56 GHFYSRISNPTlalLEQRMASLEGGEAAVA---LASGMGAITATLWTLLRPGDEV-------------IVDQTLYGCTfA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 135 FKEYNIGYNAVPLTEEGFVDFGAVATAIHSNTKMIgiqrskgYATRPSFTISQIKEmIAFVKEI--KPDVVVFVDNCYGE 212
Cdd:PRK07503  120 FLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMV-------YFETPANPNMRLVD-IAAVAEIahGAGAKVVVDNTYCT 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 213 FIeEQEPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEQYVEAcayrltspgigaeagASLYSLQEMyQGFFLAPHVAGQ 292
Cdd:PRK07503  192 PY-LQRPLELGADLVVHSATKYLGGHGDITAGLVVGGKALADR---------------IRLEGLKDM-TGAVMSPFDAFL 254


                  ....
gi 1128945374 293 ALKG 296
Cdd:PRK07503  255 LMRG 258
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 59-255 6.23e-08

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 54.45  E-value: 6.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  59 GYGYDDIGRDT---LEKVYADVFGAEAGLVRPqiiSGTHAISTALFGVLRPGDELlyITGKpydTLEEIvgvrgkgvgSF 135
Cdd:PRK06234   55 GYIYSRLGNPTsteVENKLALLEGGEAAVVAA---SGMGAISSSLWSALKAGDHV--VASD---TLYGC---------TF 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 136 KEYNIGynavpLTEEG----FVD---FGAVATAIHSNTKMIGIQRSkgyaTRPSFTISQIKEMIAFVKEIKPDVVVFVDN 208
Cdd:PRK06234  118 ALLNHG-----LTRYGvevtFVDtsnLEEVRNALKANTKVVYLETP----ANPTLKVTDIKAISNIAHENNKECLVFVDN 188

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1128945374 209 CYGE-FIeeQEPCHVGADLMAGSLIK--NPGGGIVktGGYIVGKEQYVEA 255
Cdd:PRK06234  189 TFCTpYI--QRPLQLGADVVVHSATKylNGHGDVI--AGFVVGKEEFINQ 234
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 67-296 3.23e-07

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 51.82  E-value: 3.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  67 RDTLEKVYADVFGAEAGLVRPqiiSGTHAISTALFGVLRPGDELL---YITGKPYDTLEEIvgvrgkgvgsFKEYNIgyn 143
Cdd:cd00614    42 VDALEKKLAALEGGEAALAFS---SGMAAISTVLLALLKAGDHVVasdDLYGGTYRLFERL----------LPKLGI--- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 144 avpltEEGFVDFG---AVATAIHSNTKMIgiqrskgYA---TRPSFTISQIKEMIAFVKEIkpDVVVFVDNCYGEFIeEQ 217
Cdd:cd00614   106 -----EVTFVDPDdpeALEAAIKPETKLV-------YVespTNPTLKVVDIEAIAELAHEH--GALLVVDNTFATPY-LQ 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1128945374 218 EPCHVGADLMAGSLIKNPGGGIVKTGGYIVGKEqyvEACAYRLTspgigaeagaslysLQEMYQGFFLAPHVAGQALKG 296
Cdd:cd00614   171 RPLELGADIVVHSATKYIGGHSDVIAGVVVGSG---EALIQRLR--------------FLRLALGTILSPFDAWLLLRG 232
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 48-275 3.61e-07

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 51.96  E-value: 3.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  48 KISDSHFIPTTGYGYDDIGRDTLEKVYADVFGAEAGLVRP--QII---SGTHAISTALFGVLRPGDELLYITgkP-YDTL 121
Cdd:cd00609    19 ALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPpeEIVvtnGAQEALSLLLRALLNPGDEVLVPD--PtYPGY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 122 EEIvgvrgkgvgsFKEYNIGYNAVPLTEEG--FVDFGAVATAIHSNTKMIgiqrskgYATRPS------FTISQIKEMIA 193
Cdd:cd00609    97 EAA----------ARLAGAEVVPVPLDEEGgfLLDLELLEAAKTPKTKLL-------YLNNPNnptgavLSEEELEELAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 194 FVKeiKPDVVVFVDNCYGEFIEEQEPCHVGADLMA-------GSLIKN---PGGGIvktgGYIVGKEQYVEA------CA 257
Cdd:cd00609   160 LAK--KHGILIISDEAYAELVYDGEPPPALALLDAyervivlRSFSKTfglPGLRI----GYLIAPPEELLErlkkllPY 233

                         250
                  ....*....|....*...
gi 1128945374 258 YRLTSPGIGAEAGASLYS 275
Cdd:cd00609   234 TTSGPSTLSQAAAAAALD 251
PRK03321 PRK03321
putative aminotransferase; Provisional
 109-218 1.25e-04

putative aminotransferase; Provisional


Pssm-ID: 179559  Cd Length: 352  Bit Score: 43.80  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 109 ELLYITGKPYDtlEEIVGVRgkgvgSFKEYNI-----GYNA--VPLTEEGFVDFGAVATAIHSNTKMIGIQRskgyATRP 181
Cdd:PRK03321   89 QLVQATAGPGD--EVIFAWR-----SFEAYPIlvqvaGATPvqVPLTPDHTHDLDAMAAAITDRTRLIFVCN----PNNP 157

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1128945374 182 SFTISQIKEMIAFVKEIKPDVVVFVDNCYGEFIEEQE 218
Cdd:PRK03321  158 TGTVVTPAELARFLDAVPADVLVVLDEAYVEYVRDDD 194
PLN00175 PLN00175
aminotransferase family protein; Provisional
 59-222 5.20e-04

aminotransferase family protein; Provisional


Pssm-ID: 215089 [Multi-domain]  Cd Length: 413  Bit Score: 42.16  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  59 GYGYDDigrdtLEKVYADVFGAEAGL-VRPQ----IISG-THAISTALFGVLRPGDELlyITGKP-YDTLEEIVGVRG-- 129
Cdd:PLN00175   90 GFGVPE-----LNSAIAERFKKDTGLvVDPEkevtVTSGcTEAIAATILGLINPGDEV--ILFAPfYDSYEATLSMAGak 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 130 -KGVgSFKEYNIgynAVPLTEegfvdfgaVATAIHSNTKMIGIQRSKGyATRPSFTISQIKEMIAFVKEikPDVVVFVDN 208
Cdd:PLN00175  163 iKTV-TLRPPDF---AVPEDE--------LKAAFTSKTRAILINTPHN-PTGKMFTREELELIASLCKE--NDVLAFTDE 227

                         170
                  ....*....|....
gi 1128945374 209 CYGEFIEEQEpcHV 222
Cdd:PLN00175  228 VYDKLAFEGD--HI 239
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
60-308 1.67e-03

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 40.28  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374  60 YGYDdigRDT--LEKVYADVFGAEAGLVRPQiisGTHAISTALFGVLRPGDEllYITGKP----YDT---LEEIVGVRGK 130
Cdd:pfam01212  28 YGGD---PTVnrLEDRVAELFGKEAALFVPS---GTAANQLALMAHCQRGDE--VICGEPahihFDEtggHAELGGVQPR 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 131 gvgsfkeynigynAVPLTEEGFVDFGAVATAI-------HSNTKMIGIQRSKGYATRPSFTISQIKEMIAFVKEIKPDVV 203
Cdd:pfam01212 100 -------------PLDGDEAGNMDLEDLEAAIrevgadiFPPTGLISLENTHNSAGGQVVSLENLREIAALAREHGIPVH 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1128945374 204 V----FVDNC--YGEFIEEqepCHVGADLMAGSLIKnpgGGIVKTGGYIVGKEQYVE-ACAYR------LTSPGIGAEAG 270
Cdd:pfam01212 167 LdgarFANAAvaLGVIVKE---ITSYADSVTMCLSK---GLGAPVGSVLAGSDDFIAkAIRQRkylgggLRQAGVLAAAG 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1128945374 271 asLYSLQEMYqgfflapHVAGQALKGAIFTAAFLEKLG 308
Cdd:pfam01212 241 --LRALEEGV-------ARLARDHATARRLAEGLELLR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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