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Conserved domains on  [gi|1132164263|ref|WP_075848948|]
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MULTISPECIES: signal transduction histidine-protein kinase/phosphatase UhpB [Citrobacter]

Protein Classification

sensor histidine kinase( domain architecture ID 11485444)

two-component sensor histidine kinase having a MASE1 sensory domain, similar to Escherichia coli UhpB which functions in sugar-phosphate transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
6-498 0e+00

signal transduction histidine-protein kinase/phosphatase UhpB;


:

Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 784.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263   6 SRLITVVACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLL 85
Cdd:PRK11644    3 SRLITVIACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLAQAVGLPHWLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  86 LMIGSFLTLLPVMLISRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTLAPICLVFWHYLTST 165
Cdd:PRK11644   83 LLIGSLLTLLPVALASRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKEGWNALLLTLTGGLTLAPTCLLFWHYLAQN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 166 TWLPLGPAVVSQPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIAS 245
Cdd:PRK11644  163 TWLPLGPSLVSQPVNWRGRHIVWYLLLFVLSIWLQLGLPDELSRFTPFCLAIPIIALAWRYGWQGALLATLLNAIALIAS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 246 QTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVRRDVARELHDDIGQTITAIRT 325
Cdd:PRK11644  243 QTWHDHPVDLLLSLLAQSLTGLLLGAGIQRQRELNQSLQKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRT 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 326 QAGIVQRLAPENAGVKRSGAHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMELESRGIVSHLDWRIDESA 405
Cdd:PRK11644  323 QAGIIKRLAADNASVKQSAQLIEQLSLGVYDTVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEDRGIVSHLDWRIDESA 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 406 LSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSNQQGFGLTGMRERITALGGSLSISC 485
Cdd:PRK11644  403 LSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGFGLRGMRERVTALGGTLTISC 482

                         490
                  ....*....|...
gi 1132164263 486 THGTRVSVSLPQR 498
Cdd:PRK11644  483 THGTRLSVSLPQR 495
 
Name Accession Description Interval E-value
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
6-498 0e+00

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 784.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263   6 SRLITVVACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLL 85
Cdd:PRK11644    3 SRLITVIACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLAQAVGLPHWLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  86 LMIGSFLTLLPVMLISRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTLAPICLVFWHYLTST 165
Cdd:PRK11644   83 LLIGSLLTLLPVALASRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKEGWNALLLTLTGGLTLAPTCLLFWHYLAQN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 166 TWLPLGPAVVSQPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIAS 245
Cdd:PRK11644  163 TWLPLGPSLVSQPVNWRGRHIVWYLLLFVLSIWLQLGLPDELSRFTPFCLAIPIIALAWRYGWQGALLATLLNAIALIAS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 246 QTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVRRDVARELHDDIGQTITAIRT 325
Cdd:PRK11644  243 QTWHDHPVDLLLSLLAQSLTGLLLGAGIQRQRELNQSLQKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRT 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 326 QAGIVQRLAPENAGVKRSGAHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMELESRGIVSHLDWRIDESA 405
Cdd:PRK11644  323 QAGIIKRLAADNASVKQSAQLIEQLSLGVYDTVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEDRGIVSHLDWRIDESA 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 406 LSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSNQQGFGLTGMRERITALGGSLSISC 485
Cdd:PRK11644  403 LSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGFGLRGMRERVTALGGTLTISC 482

                         490
                  ....*....|...
gi 1132164263 486 THGTRVSVSLPQR 498
Cdd:PRK11644  483 THGTRLSVSLPQR 495
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 6-496 8.80e-172

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 492.98  E-value: 8.80e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263   6 SRLITVVACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLL 85
Cdd:COG3851     2 QRLILSLFAFFLYSLAWFCLWAISFYLVRDPELAVLFLPFGLRLGLLLLTPRRYWPALLLAEWALLAWLAIELGLLGLLW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  86 LMIGSFLTLLPVMLISRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTLAPICLVFWHYLTST 165
Cdd:COG3851    82 VLLASLLSLPAVALARRYWRRLYWQRLLVLLALVLLTALLNTLVSLLLGTSAAQVLLGSLTGGLLLAPFCYLIWEYLFQQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 166 TWlplgpavvsqPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIAS 245
Cdd:COG3851   162 SK----------PIRLRTSHLLWYLLLFALSILLQLQLTAELRRFALFCLAIPIIFLAYRYGWQGAVLATLLNSVALIAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 246 QT--WHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVRRDVARELHDDIGQTITAI 323
Cdd:COG3851   232 RQisSFHPLADLLLFLAAQSLTGLLLGAAIQRQRQLNQQLEQELRENRALARQLVSAEESERREIARELHDEIGQNITAI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 324 RTQAGIVQRLAPeNAGVKRSGAHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMELESRGIVSHLDWRIDE 403
Cdd:COG3851   312 RTQASILKRLAP-QPEIEQSAQSIESLALRIYDTTRRLLDRLRPAVLDELGLEEALRELPRELAFEEPGISCQLDLRGDP 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 404 SALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSNQQGFGLTGMRERITALGGSLSI 483
Cdd:COG3851   391 SLLDDTLQLTLYRLVQEALTNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAKGFGLRGMRERVRALGGDFRL 470

                         490
                  ....*....|....
gi 1132164263 484 SC-THGTRVSVSLP 496
Cdd:COG3851   471 SSaPKGTRLSVLLP 484
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 414-496 1.67e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 105.33  E-value: 1.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 414 LFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSG--LPPGSNQQGFGLTGMRERITALGGSLSISCT--HGT 489
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGfdGPAPPGGGGFGLLGMRERAELLGGTLTIGSRpgGGT 80


                  ....*..
gi 1132164263 490 RVSVSLP 496
Cdd:cd16917    81 RVTARLP 87
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 414-498 7.24e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.90  E-value: 7.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  414 LFRVCQEGLNNIVKHANASA-VTLQGWQQDERLMLVIEDDGSGLPP------------------GSNQQGFGLTGMRERI 474
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGrITVTLERDGDHVEITVEDNGPGIPPedlekifepffrtdkrsrKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*.
gi 1132164263  475 TALGGSLSISCT--HGTRVSVSLPQR 498
Cdd:smart00387  86 ELHGGEISVESEpgGGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 411-496 1.04e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 58.53  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 411 RVTLFRVCQEGLNNIVKHANASA---VTLQgwqQDERLMLVIEDDGSGLPP----------------GSNQQGFGLTGMR 471
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGeitVTLS---EGGELTLTVEDNGIGIPPedlprifepfstadkrGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 1132164263 472 ERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:pfam02518  80 KLVELLGGTITVESEpgGGTTVTLTLP 106
 
Name Accession Description Interval E-value
PRK11644 PRK11644
signal transduction histidine-protein kinase/phosphatase UhpB;
6-498 0e+00

signal transduction histidine-protein kinase/phosphatase UhpB;


Pssm-ID: 236945 [Multi-domain]  Cd Length: 495  Bit Score: 784.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263   6 SRLITVVACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLL 85
Cdd:PRK11644    3 SRLITVIACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLIYWLAQAVGLPHWLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  86 LMIGSFLTLLPVMLISRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTLAPICLVFWHYLTST 165
Cdd:PRK11644   83 LLIGSLLTLLPVALASRYRHQRDWRTLLLQGAALTAAALLQSLPWLWHGKEGWNALLLTLTGGLTLAPTCLLFWHYLAQN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 166 TWLPLGPAVVSQPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIAS 245
Cdd:PRK11644  163 TWLPLGPSLVSQPVNWRGRHIVWYLLLFVLSIWLQLGLPDELSRFTPFCLAIPIIALAWRYGWQGALLATLLNAIALIAS 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 246 QTWHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVRRDVARELHDDIGQTITAIRT 325
Cdd:PRK11644  243 QTWHDHPVDLLLSLLAQSLTGLLLGAGIQRQRELNQSLQKELARNRHLAERLLETEESVRRDVARELHDEIGQTITAIRT 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 326 QAGIVQRLAPENAGVKRSGAHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMELESRGIVSHLDWRIDESA 405
Cdd:PRK11644  323 QAGIIKRLAADNASVKQSAQLIEQLSLGVYDTVRRLLGRLRPRQLDDLTLEQAIRSLMREMELEDRGIVSHLDWRIDESA 402

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 406 LSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSNQQGFGLTGMRERITALGGSLSISC 485
Cdd:PRK11644  403 LSETQRVTLFRVCQEGLNNIVKHADASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQGFGLRGMRERVTALGGTLTISC 482

                         490
                  ....*....|...
gi 1132164263 486 THGTRVSVSLPQR 498
Cdd:PRK11644  483 THGTRLSVSLPQR 495
UhpB COG3851
Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction ...
 6-496 8.80e-172

Signal transduction histidine kinase UhpB, glucose-6-phosphate specific [Signal transduction mechanisms];


Pssm-ID: 443060 [Multi-domain]  Cd Length: 493  Bit Score: 492.98  E-value: 8.80e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263   6 SRLITVVACFFIFSAAWFCLWSISLHLVERPELAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLL 85
Cdd:COG3851     2 QRLILSLFAFFLYSLAWFCLWAISFYLVRDPELAVLFLPFGLRLGLLLLTPRRYWPALLLAEWALLAWLAIELGLLGLLW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  86 LMIGSFLTLLPVMLISRYRHQRDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTLAPICLVFWHYLTST 165
Cdd:COG3851    82 VLLASLLSLPAVALARRYWRRLYWQRLLVLLALVLLTALLNTLVSLLLGTSAAQVLLGSLTGGLLLAPFCYLIWEYLFQQ 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 166 TWlplgpavvsqPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIAS 245
Cdd:COG3851   162 SK----------PIRLRTSHLLWYLLLFALSILLQLQLTAELRRFALFCLAIPIIFLAYRYGWQGAVLATLLNSVALIAA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 246 QT--WHDHPVDLLLSLLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVRRDVARELHDDIGQTITAI 323
Cdd:COG3851   232 RQisSFHPLADLLLFLAAQSLTGLLLGAAIQRQRQLNQQLEQELRENRALARQLVSAEESERREIARELHDEIGQNITAI 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 324 RTQAGIVQRLAPeNAGVKRSGAHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMELESRGIVSHLDWRIDE 403
Cdd:COG3851   312 RTQASILKRLAP-QPEIEQSAQSIESLALRIYDTTRRLLDRLRPAVLDELGLEEALRELPRELAFEEPGISCQLDLRGDP 390

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 404 SALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGSNQQGFGLTGMRERITALGGSLSI 483
Cdd:COG3851   391 SLLDDTLQLTLYRLVQEALTNILKHAEASQIRISLSQDKRLLSLEIRDDGIGLPPELRAKGFGLRGMRERVRALGGDFRL 470

                         490
                  ....*....|....
gi 1132164263 484 SC-THGTRVSVSLP 496
Cdd:COG3851   471 SSaPKGTRLSVLLP 484
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
266-496 2.86e-45

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 159.01  E-value: 2.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 266 GLLLGAGIQRLRELNQslQNELARnhRLAERLLETEESVRRDVARELHDDIGQTITAIRTQAGIVQRLAPEN-AGVKRSG 344
Cdd:COG4585    19 GLLLALVLLRARRAER--AAELER--ELAARAEEAREEERRRIARELHDGVGQSLSAIKLQLEAARRLLDADpEAAREEL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 345 AHIEQLSLGVYDSVRRLLGRLRPRQLDDLTLEQAIRSLMREMElESRGIVSHLDWRIDESALSESQRVTLFRVCQEGLNN 424
Cdd:COG4585    95 EEIRELAREALAELRRLVRGLRPPALDDLGLAAALEELAERLL-RAAGIRVELDVDGDPDRLPPEVELALYRIVQEALTN 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1132164263 425 IVKHANASAVTLQGWQQDERLMLVIEDDGSGLPPGS-NQQGFGLTGMRERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:COG4585   174 ALKHAGATRVTVTLEVDDGELTLTVRDDGVGFDPEAaPGGGLGLRGMRERAEALGGTLTIGSApgGGTRVRATLP 248
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 414-496 1.67e-27

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 105.33  E-value: 1.67e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 414 LFRVCQEGLNNIVKHANASAVTLQGWQQDERLMLVIEDDGSG--LPPGSNQQGFGLTGMRERITALGGSLSISCT--HGT 489
Cdd:cd16917     1 LYRIVQEALTNALKHAGASRVRVTLSYTADELTLTVVDDGVGfdGPAPPGGGGFGLLGMRERAELLGGTLTIGSRpgGGT 80


                  ....*..
gi 1132164263 490 RVSVSLP 496
Cdd:cd16917    81 RVTARLP 87
PRK10935 PRK10935
nitrate/nitrite two-component system sensor histidine kinase NarQ;
279-497 9.03e-13

nitrate/nitrite two-component system sensor histidine kinase NarQ;


Pssm-ID: 236800 [Multi-domain]  Cd Length: 565  Bit Score: 70.27  E-value: 9.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 279 LNQSLQNELAR------NHRLAERLLETEEsvRRDVARELHDDIGQTITAIRTQAGIVQR-LAPENAgvkRSGAHIEQLS 351
Cdd:PRK10935  334 LMNNVAQMLGRglyfnqAQKQQQQLLLMEE--RATIARELHDSLAQVLSYLKIQLTLLKRsLDEDNA---KAQSIIAEFD 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 352 LGVYDSVRRLLGRLRPRQlddLTLEQA-IRSLMREMeLES-RGIVS---HLDWRIDESALSESQRVTLFRVCQEGLNNIV 426
Cdd:PRK10935  409 QALSDAYRQLRELLTTFR---LTIQEAnLGSALEEM-LDQlRNQTDakiTLDCRLPSQALDAQQQVHLLQIIREATLNAI 484

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1132164263 427 KHANASAVTLQGWQQ-DERLMLVIEDDGSGLPPGSNQQG-FGLTGMRERITALGGSLSISC--THGTRVSVSLPQ 497
Cdd:PRK10935  485 KHANASEIAVSCVTNpDGEHTVSIRDDGIGIGELKEPEGhYGLNIMQERAERLGGTLTISQppGGGTTVSLTFPS 559
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 414-498 7.24e-12

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 61.90  E-value: 7.24e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  414 LFRVCQEGLNNIVKHANASA-VTLQGWQQDERLMLVIEDDGSGLPP------------------GSNQQGFGLTGMRERI 474
Cdd:smart00387   6 LRQVLSNLLDNAIKYTPEGGrITVTLERDGDHVEITVEDNGPGIPPedlekifepffrtdkrsrKIGGTGLGLSIVKKLV 85

                           90       100
                   ....*....|....*....|....*.
gi 1132164263  475 TALGGSLSISCT--HGTRVSVSLPQR 498
Cdd:smart00387  86 ELHGGEISVESEpgGGTTFTITLPLE 111
PRK10600 PRK10600
nitrate/nitrite two-component system sensor histidine kinase NarX;
287-494 1.03e-10

nitrate/nitrite two-component system sensor histidine kinase NarX;


Pssm-ID: 182581 [Multi-domain]  Cd Length: 569  Bit Score: 63.92  E-value: 1.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 287 LARNHRLAERLLETEEsvRRDVARELHDDIGQTITAIRTQAGIVQ----RLAPEnagvkrSGAHIEQL--SLGVYDSVRR 360
Cdd:PRK10600  346 LERQQERQQQLIVMEE--RATIARELHDSIAQSLSCMKMQVSCLQmqgdALPES------SRELLSQIrnELNASWRQLR 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 361 LLGRLRPRQLDDLTLEQAIRSLMREMElESRGIVSHLDWRIDESALSESQRVTLFRVCQEGLNNIVKHANASAVTLQGWQ 440
Cdd:PRK10600  418 ELLTTFRLQLTEPGLRPALEASCEEFS-ARFGFPVKLDYQLPPRLVPSHQAIHLLQIAREALSNALKHAQASEVVVTVAQ 496

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1132164263 441 QDERLMLVIEDDGSGLPPGSNQQG-FGLTGMRERITALGGSLSIS--CTHGTRVSVS 494
Cdd:PRK10600  497 NQNQVKLSVQDNGCGVPENAERSNhYGLIIMRDRAQSLRGDCRVRrrESGGTEVVVT 553
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 411-496 1.04e-10

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 58.53  E-value: 1.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 411 RVTLFRVCQEGLNNIVKHANASA---VTLQgwqQDERLMLVIEDDGSGLPP----------------GSNQQGFGLTGMR 471
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKHAAKAGeitVTLS---EGGELTLTVEDNGIGIPPedlprifepfstadkrGGGGTGLGLSIVR 79

                          90       100
                  ....*....|....*....|....*..
gi 1132164263 472 ERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:pfam02518  80 KLVELLGGTITVESEpgGGTTVTLTLP 106
MASE1 pfam05231
MASE1; Predicted integral membrane sensory domain found in histidine kinases, diguanylate ...
 10-243 3.74e-10

MASE1; Predicted integral membrane sensory domain found in histidine kinases, diguanylate cyclases and other bacterial signaling proteins. This entry also includes members of the 8 transmembrane UhpB type (8TMR-UT) domain family.


Pssm-ID: 428383 [Multi-domain]  Cd Length: 299  Bit Score: 60.89  E-value: 3.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  10 TVVACFFIFSAAWFCLWSISLHLVERPeLAVLLFPFGLRLGLMLQCPRGYWPVLLGAEWLLLFWLAQEVALAHLLLLMIG 89
Cdd:pfam05231   1 LLLLLLLLYALLAAVSLSLALALVSSG-SAPIWLPTGLALAALLLFGRRGWPGILLGAVLASLMAGLLSGLNLLLALAIA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263  90 SFLTLLPVMLISRYRHQ---RDWRTLLLQGAALTAAALLQSLPWLGQGEEAWNALLLTLTGGLTL--------------- 151
Cdd:pfam05231  80 AVNALEALLGAALLRRLlpgRNRLQRLRFWLRLVIPGAIIAALLLAIIGLALLLLLGLIPLAPFSivwltwwlgsatgvl 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 152 --APICLVFWHYLTSTTWLPLGPAVVSQPVNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQ 229
Cdd:pfam05231 160 vvTPLLLLLRRYLRLRHRLRLWYERDLAPAAAKLLLLFALLLLLILSLLLLLLCMPEINYPLGYLLLPPLLWAAFRFGVR 239

                         250
                  ....*....|....
gi 1132164263 230 GALIATLMNAIALI 243
Cdd:pfam05231 240 GGSLAALLLAVLLI 253
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 179-496 2.57e-07

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 52.99  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 179 VNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIASQTWHDHPVDLLLS 258
Cdd:COG3920   173 AAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAVLEELERRRRARGLGR 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 259 LLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETEESVrrdvARELHDDIG---QTITAI-RTQAGIVQRLA 334
Cdd:COG3920   253 LLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELL----LRELHHRVKnnlQVVSSLlRLQARRADDPE 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 335 PENAgVKRSGAHIEQLSLgVYDSVRRLLGRlrprqlDDLTLEQAIRSLMREMELESRGIVSHLDWRIDESALSESQRVTL 414
Cdd:COG3920   329 AREA-LEESQNRIQALAL-VHELLYQSEDW------EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAAVPL 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 415 FRVCQEGLNNIVKHANASA----VTLQGWQQDERLMLVIEDDGSGLPPG---SNQQGFGLTGMRERITALGGSLSISCTH 487
Cdd:COG3920   401 GLILNELVTNALKHAFLSGeggrIRVSWRREDGRLRLTVSDNGVGLPEDvdpPARKGLGLRLIRALVRQLGGTLELDRPE 480


                  ....*....
gi 1132164263 488 GTRVSVSLP 496
Cdd:COG3920   481 GTRVRITFP 489
HisKA_3 pfam07730
Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of ...
 305-358 2.83e-06

Histidine kinase; This is the dimerization and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with pfam00512 and pfam07536.


Pssm-ID: 429624 [Multi-domain]  Cd Length: 68  Bit Score: 44.92  E-value: 2.83e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1132164263 305 RRDVARELHDDIGQTITAIRTQAGIVQRLAPENAG-VKRSGAHIEQLSLGVYDSV 358
Cdd:pfam07730   2 RNRIARELHDSVGQSLTAIKLQLELARRLLDRDPEeAREQLDAIRELAREALQEL 56
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
375-496 7.60e-06

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 47.21  E-value: 7.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 375 LEQAIRSLmrEMELESRGIvsHLDWRIDESALS-ESQRVTLFRVCQEGLNNIVKHANA-SAVTLQGWQQDERLMLVIEDD 452
Cdd:COG2205    97 LEEAVEEL--RPLAEEKGI--RLELDLPPELPLvYADPELLEQVLANLLDNAIKYSPPgGTITISARREGDGVRISVSDN 172

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1132164263 453 GSGLPPG---------------SNQQGFGLtGM---RERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:COG2205   173 GPGIPEEeleriferfyrgdnsRGEGGTGL-GLaivKRIVEAHGGTIWVESEpgGGTTFTVTLP 235
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
186-496 1.13e-05

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 47.21  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 186 LVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIASQTWHDHPVDLLLSLLVQSLT 265
Cdd:COG0642    13 LLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 266 GLLLGAGIQRLRELNQSLQNELArnhrlaerlleteesvrrDVArelHDdIGQTITAIRTQAGIVQRLAPEN-----AGV 340
Cdd:COG0642    93 LLLLLALLLLLEEANEAKSRFLA------------------NVS---HE-LRTPLTAIRGYLELLLEELDEEqreylETI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 341 KRSGAHIEQ-----LSLGVYDSvrrllgRLRPRQLDDLTLEQAIRSLMREME--LESRGIvsHLDWRIDESALS-ESQRV 412
Cdd:COG0642   151 LRSADRLLRlindlLDLSRLEA------GKLELEPEPVDLAELLEEVVELFRplAEEKGI--ELELDLPDDLPTvRGDPD 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 413 TLFRVCQEGLNNIVKHANA-SAVTLQGWQQDERLMLVIEDDGSGLPP---------------GSNQQGFGLtGM---RER 473
Cdd:COG0642   223 RLRQVLLNLLSNAIKYTPEgGTVTVSVRREGDRVRISVEDTGPGIPPedlerifepffrtdpSRRGGGTGL-GLaivKRI 301

                         330       340
                  ....*....|....*....|....*
gi 1132164263 474 ITALGGSLSISCTH--GTRVSVSLP 496
Cdd:COG0642   302 VELHGGTIEVESEPgkGTTFTVTLP 326
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 424-496 1.27e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 43.97  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 424 NIVKHA-----NASAVTLQGWQQDERLMLVIEDDGSGLPP------GSNQ---QGFGLTGMRERITALGG---SLSISCT 486
Cdd:cd16924    12 NAIQHGlspltDKGVVTISALKEDNHVMIEVEDNGRGIDPkvlnilGKKPkegNGIGLYNVHQRLILLFGedyGIHIASE 91

                          90
                  ....*....|..
gi 1132164263 487 H--GTRVSVSLP 496
Cdd:cd16924    92 PdkGTRITFTIP 103
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
417-471 2.63e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 43.75  E-value: 2.63e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1132164263 417 VCQEGLNNIVKHANASA----VTLQGWQQDERLMLVIEDDGSGLPPGSNQQ--------GFGLTGMR 471
Cdd:COG2172    38 AVSEAVTNAVRHAYGGDpdgpVEVELELDPDGLEIEVRDEGPGFDPEDLPDpystlaegGRGLFLIR 104
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 397-495 6.60e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 42.62  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 397 LDWRIDESALSESQRVTLFRVCQEGLNNIVKHANaSAVTLQGWQQDERLMLVIEDDGSGLPPGSNQ-------------- 462
Cdd:cd16954    21 ISLDISPELRFPGERNDLMELLGNLLDNACKWCL-EFVEVTARQTDGGLHLIVDDDGPGVPESQRSkifqrgqrldeqrp 99

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1132164263 463 -QGFGLTGMRERITALGGSLSISCTH--GTRVSVSL 495
Cdd:cd16954   100 gQGLGLAIAKEIVEQYGGELSLSDSPlgGARFEVVF 135
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
434-496 3.36e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 43.08  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 434 VTLQGWQQDERLMLVIEDDGSGLPP------------GSNQQGFGLTGMRERITAL---GGSLSISCT--HGTRVSVSLP 496
Cdd:COG2972   362 IRISIRKEGDRLVITVEDNGVGMPEekleklleelssKGEGRGIGLRNVRERLKLYygeEYGLEIESEpgEGTTVTIRIP 441
HATPase_YehU-like cd16956
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 424-496 6.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.


Pssm-ID: 340432 [Multi-domain]  Cd Length: 101  Bit Score: 39.34  E-value: 6.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 424 NIVKH-----ANASAVTLQGWQQDERLMLVIEDDGSGLPP-------GSNQQGFGLTGMRERITALGGS---LSISCT-- 486
Cdd:cd16956    12 NAVKHglsglLDGGRVEITARLDGQHLLLEVEDNGGGMDPdtlarilIRSSNGLGLNLVDKRLRQAFGNdygLDIECApg 91

                          90
                  ....*....|
gi 1132164263 487 HGTRVSVSLP 496
Cdd:cd16956    92 EGTRITIRLP 101
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 434-496 6.90e-04

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 42.14  E-value: 6.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1132164263 434 VTLQGWQQDERLMLVIEDDGSGLPP--------------GSNQQGFGLTGMRERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:COG3290   307 VELSIRDDGDELVIEVEDSGPGIPEellekifergfstkLGEGRGLGLALVKQIVEKYGGTIEVESEegEGTVFTVRLP 385
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 417-496 1.29e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 38.94  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 417 VCQEGLNNIVKHA----NASAVTLQGWQQDERLMLVIEDDGSGLPPGS---NQQGFGLTGMRERITALGGSLSI--SCTH 487
Cdd:cd16951    43 VVNELLQNALKHAfsdrEGGTITIRSVVDGDYLRITVIDDGVGLPQDEdwpNKGSLGLQIVRSLVEGELKAFLEvqSAEN 122


                  ....*....
gi 1132164263 488 GTRVSVSLP 496
Cdd:cd16951   123 GTRVNIDIP 131
PRK13560 PRK13560
hypothetical protein; Provisional
 372-496 3.48e-03

hypothetical protein; Provisional


Pssm-ID: 106506 [Multi-domain]  Cd Length: 807  Bit Score: 40.04  E-value: 3.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 372 DLTLEQAIRSLMREMELESRGIVSHLDWRID--ESALSESQRVTLFRVCQEGLNNIVKHA----NASAVTLQGWQQ-DER 444
Cdd:PRK13560  668 DIDFLDYIESLTAHLKNSFAIDFGRIDCKIDadDGCLDIDKAIPCGLIISELLSNALKHAfpdgAAGNIKVEIREQgDGM 747

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1132164263 445 LMLVIEDDGSGLPPG---SNQQGFGLTGMRERITALGGSLSISCTHGTRVSVSLP 496
Cdd:PRK13560  748 VNLCVADDGIGLPAGfdfRAAETLGLQLVCALVKQLDGEIALDSRGGARFNIRFP 802
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 422-496 5.84e-03

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 39.17  E-value: 5.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 422 LNNIVKHA-----NASAVTLQGWQQDERLMLVIEDDGSGLPP----------------GSnqqGFGLTGMRERITALGGS 480
Cdd:COG5000   322 LINLLKNAieaieEGGEIEVSTRREDGRVRIEVSDNGPGIPEevlerifepffttkpkGT---GLGLAIVKKIVEEHGGT 398

                          90
                  ....*....|....*...
gi 1132164263 481 LSISCT--HGTRVSVSLP 496
Cdd:COG5000   399 IELESRpgGGTTFTIRLP 416
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 179-496 5.92e-03

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 39.01  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 179 VNWRGRHLVWYLLLFSVSLWLQLGLPDELSRFTPFCLALPIIALAWHYGWQGALIATLMNAIALIASQTWHDHPVDLLLS 258
Cdd:COG4191    15 LRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 259 LLVQSLTGLLLGAGIQRLRELNQSLQNELARNHRLAERLLETE--ESVRR---DVArelHDdIGQTITAIRTQAGIVQRL 333
Cdd:COG4191    95 LLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSEklAALGElaaGIA---HE-INNPLAAILGNAELLRRR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 334 APENA--------------GVKRSGAHIEQLsLGVYDsvrrllgrLRPRQLDDLTLEQAIRSLMR--EMELESRGIvsHL 397
Cdd:COG4191   171 LEDEPdpeelrealerileGAERAAEIVRSL-RAFSR--------RDEEEREPVDLNELIDEALEllRPRLKARGI--EV 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132164263 398 DWRIDESALS-ESQRVTLFRVcqegLNNIVK---HANASA----VTLQGWQQDERLMLVIEDDGSGLPPG---------- 459
Cdd:COG4191   240 ELDLPPDLPPvLGDPGQLEQV----LLNLLInaiDAMEEGeggrITISTRREGDYVVISVRDNGPGIPPEvlerifepff 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1132164263 460 ---SNQQGFGLtGM---RERITALGGSLSISCT--HGTRVSVSLP 496
Cdd:COG4191   316 ttkPVGKGTGL-GLsisYGIVEKHGGRIEVESEpgGGTTFTITLP 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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