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Conserved domains on  [gi|1137717711|ref|WP_076611659|]
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IS1-like element ISMbu3 family transposase [Methanococcoides burtonii]

Protein Classification

IS1-like element transposase( domain architecture ID 1750064)

IS1-like element transposase acting on a specific type of insertion sequences (IS), the simplest class of procaryotic transposable elements which are capable of integrating into numerous sites within genomes via a transposition pathway independent of homologous re combination.

Gene Ontology:  GO:0006313

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 3-196 7.25e-91

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


:

Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 265.29  E-value: 7.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   3 CPRCKSSNHKKNGKI-DGRQRYKCHDCGYSYSVEIKSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG 81
Cdd:NF033558    1 CPRCQSDNVVKNGKSvRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  82 R---ELEDLKSENEISIVELDEMHTYIGNKK-YCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHW 157
Cdd:NF033558   81 PrqvTPEPLKPADIVLICELDELWTFVGNKKnKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDHW 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1137717711 158 RAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLARLRRK 196
Cdd:NF033558  161 KVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 3-196 7.25e-91

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 265.29  E-value: 7.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   3 CPRCKSSNHKKNGKI-DGRQRYKCHDCGYSYSVEIKSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG 81
Cdd:NF033558    1 CPRCQSDNVVKNGKSvRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  82 R---ELEDLKSENEISIVELDEMHTYIGNKK-YCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHW 157
Cdd:NF033558   81 PrqvTPEPLKPADIVLICELDELWTFVGNKKnKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDHW 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1137717711 158 RAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLARLRRK 196
Cdd:NF033558  161 KVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
InsB COG1662
Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];
34-222 3.62e-53

Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];


Pssm-ID: 441268 [Multi-domain]  Cd Length: 193  Bit Score: 169.50  E-value: 3.62e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  34 VEIKSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG-RELEDLKSENEISIVELDEMHTYIGNKK-YC 111
Cdd:COG1662     1 KLQRAISEELKILIDRVEIELIGLALLARGVGLSISALIITVNTKLVAvYVQLKVPNLSDKRLVEVDELWTFVGSKKnKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711 112 WIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHWRAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLA 191
Cdd:COG1662    81 WIWYAVDRDTGRIVAFVVGDRDKKTARKLWEKLKPFEIAVIYTDGWKAYASLIPEKRHVVSKGYTNHIERNNLTLRHRLK 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1137717711 192 RLRRKSKCYTKSLEMLKYSVLLLMKYRNKEL 222
Cdd:COG1662   161 RLVRKTICFSKSLEMHDKAIKLFFHYYNFGL 191
DDE_Tnp_IS1 pfam03400
IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This ...
 97-206 1.26e-15

IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.


Pssm-ID: 281403  Cd Length: 131  Bit Score: 70.77  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  97 ELDEMHTYIGNK-KYCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHWRAYAEFVPEKIHTQSKAE 175
Cdd:pfam03400   6 ELDEQWGFVGAKaRQHWLFYAYDRKRGGVLAHTFGERTDATCGELLALLSPFDIGILMSDDWGLYERELKGDKHLIGKIF 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1137717711 176 TYTVEGYNSIFRHFLARLRRKSKCYTKSLEM 206
Cdd:pfam03400  86 TQRIERHNLNLRQHIARLARKSICFSKSVEI 116
transpos_IS6 NF033587
IS6 family transposase;
42-121 1.30e-06

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 47.18  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  42 PMSVKRQALQLYLEG-LGFRSIGRFLG-----VSHVSVQKWIKKFGRELED---LKSENEISIVELDEmhTYIG-NKKYC 111
Cdd:NF033587    7 PPEIILLAVRLYLRGpLSLRDVEEILAergvsVSHSTIYRWVHKYAPQLAKrlrRRKPRPPDSWAVDE--TVIKiNGKWY 84

                          90
                  ....*....|
gi 1137717711 112 WIWIAVDRDG 121
Cdd:NF033587   85 YLYRAVDKEG 94
transpos_ISL3 NF033550
ISL3 family transposase;
3-126 6.19e-04

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   3 CPRC--KSSNHKKNGK-------IDGR--------QRYKCHDCGYSYSVEIkSTASPMS-----VKRQALQLYLEGLGFR 60
Cdd:NF033550   13 CPECgkPSRRVHDTGKrrirhlpIFGRpvylelrvRRFKCPECGKTFTEEL-PWARKRSritlrLEAAVLALLLELMSVA 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137717711  61 SIGRFLGVSHVSVQKWIKKFGRELEDLKSENEISIVELDEmHTYIGNKKYcwIWIAVDRDGKRFID 126
Cdd:NF033550   92 AVARQLGVSWSTVWRILLRAVRRLLAKRDPRLPRVLGVDE-FALRKGHKY--VTVIVDLETGRVLD 154
 
Name Accession Description Interval E-value
transpos_IS1 NF033558
IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family ...
 3-196 7.25e-91

IS1 family transposase; Proteins of this family are DDE transposases encoded by the IS1 family elements usually through a translational frameshift mechanism.


Pssm-ID: 468085 [Multi-domain]  Cd Length: 199  Bit Score: 265.29  E-value: 7.25e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   3 CPRCKSSNHKKNGKI-DGRQRYKCHDCGYSYSVEIKSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG 81
Cdd:NF033558    1 CPRCQSDNVVKNGKSvRGKQRYRCKDCGRQFQLDYEYRGYSEGTKEKILQLYLNGMGFRAIARVLGVSHNTVLRWLKKLG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  82 R---ELEDLKSENEISIVELDEMHTYIGNKK-YCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHW 157
Cdd:NF033558   81 PrqvTPEPLKPADIVLICELDELWTFVGNKKnKRWLWYAYDRKTKRILAYVFGDRSAETFRKLWALLKPFKIGFYCTDHW 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1137717711 158 RAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLARLRRK 196
Cdd:NF033558  161 KVYAEFLPDEKHLVSKGETQRIERENLTLRHRLARLVRK 199
InsB COG1662
Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];
34-222 3.62e-53

Transposase and inactivated derivatives, IS1 family [Mobilome: prophages, transposons];


Pssm-ID: 441268 [Multi-domain]  Cd Length: 193  Bit Score: 169.50  E-value: 3.62e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  34 VEIKSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG-RELEDLKSENEISIVELDEMHTYIGNKK-YC 111
Cdd:COG1662     1 KLQRAISEELKILIDRVEIELIGLALLARGVGLSISALIITVNTKLVAvYVQLKVPNLSDKRLVEVDELWTFVGSKKnKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711 112 WIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHWRAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLA 191
Cdd:COG1662    81 WIWYAVDRDTGRIVAFVVGDRDKKTARKLWEKLKPFEIAVIYTDGWKAYASLIPEKRHVVSKGYTNHIERNNLTLRHRLK 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1137717711 192 RLRRKSKCYTKSLEMLKYSVLLLMKYRNKEL 222
Cdd:COG1662   161 RLVRKTICFSKSLEMHDKAIKLFFHYYNFGL 191
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
1-220 1.80e-27

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 104.95  E-value: 1.80e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   1 MNCPRCKSSNHKKNGKI-DGRQRYKCHDCGYSYSVEIKS--TASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWI 77
Cdd:COG3677    17 PVCPHCGSTRIVKNGKTrNGRQRYRCKDCGRTFTVTTGTifEGSKLPLWLQAIRLLLNGISLRQIARVLGVSYKTVWRWL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  78 KKFGRELEDLKSENEISIVELDEMHTYIGNKKYCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHW 157
Cdd:COG3677    97 HRIREALDELVDEVDEGEGLVGEEDEKTKSKRRRKRGKKLVKGLKKGVVVKVRARGARKSKLAVRLELADLLLRRIILAA 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1137717711 158 RAYAEFVPEKIHTQSKAETYTVEGYNSIFRHFLARLRRKSKCYTKSLEMLKYSVLLLMKYRNK 220
Cdd:COG3677   177 LVAPLATDLAVGVDSKKHELLELARHTRRRRYRRLVRKAERFSKKSRNRILASWTVRHHYVYV 239
DDE_Tnp_IS1 pfam03400
IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This ...
 97-206 1.26e-15

IS1 transposase; Transposase proteins are necessary for efficient DNA transposition. This family represents bacterial IS1 transposases.


Pssm-ID: 281403  Cd Length: 131  Bit Score: 70.77  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  97 ELDEMHTYIGNK-KYCWIWIAVDRDGKRFIDCSFGSRGTETGLKLWKKLKGKEIGEVMTDHWRAYAEFVPEKIHTQSKAE 175
Cdd:pfam03400   6 ELDEQWGFVGAKaRQHWLFYAYDRKRGGVLAHTFGERTDATCGELLALLSPFDIGILMSDDWGLYERELKGDKHLIGKIF 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1137717711 176 TYTVEGYNSIFRHFLARLRRKSKCYTKSLEM 206
Cdd:pfam03400  86 TQRIERHNLNLRQHIARLARKSICFSKSVEI 116
Rve COG3316
Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];
42-122 6.92e-08

Transposase (or an inactivated derivative), DDE domain [Mobilome: prophages, transposons];


Pssm-ID: 442545 [Multi-domain]  Cd Length: 235  Bit Score: 51.44  E-value: 6.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  42 PMSVKRQALQLYLE-GLGFRSIGRFL-----GVSHVSVQKWIKKFGRELEDL---KSENEISIVELDEmhTYIG-NKKYC 111
Cdd:COG3316    10 PPEIILLAVRLYLRyGLSLRDVEEMLaergvDVSHSTIYRWVQKFAPLIAKRlrrRRPPLSDSWHVDE--TYIKiKGKWH 87

                          90
                  ....*....|.
gi 1137717711 112 WIWIAVDRDGK 122
Cdd:COG3316    88 YLYRAVDAEGR 98
transpos_IS6 NF033587
IS6 family transposase;
42-121 1.30e-06

IS6 family transposase;


Pssm-ID: 411209 [Multi-domain]  Cd Length: 203  Bit Score: 47.18  E-value: 1.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711  42 PMSVKRQALQLYLEG-LGFRSIGRFLG-----VSHVSVQKWIKKFGRELED---LKSENEISIVELDEmhTYIG-NKKYC 111
Cdd:NF033587    7 PPEIILLAVRLYLRGpLSLRDVEEILAergvsVSHSTIYRWVHKYAPQLAKrlrRRKPRPPDSWAVDE--TVIKiNGKWY 84

                          90
                  ....*....|
gi 1137717711 112 WIWIAVDRDG 121
Cdd:NF033587   85 YLYRAVDKEG 94
HTH_23 pfam13384
Homeodomain-like domain;
45-88 1.08e-04

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 38.79  E-value: 1.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1137717711  45 VKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFGRE-LEDLK 88
Cdd:pfam13384   6 RRARALLLLAEGLSVKEIAELLGVSRRTVYRWLKRYNEEgLEGLL 50
transpos_ISL3 NF033550
ISL3 family transposase;
3-126 6.19e-04

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 6.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1137717711   3 CPRC--KSSNHKKNGK-------IDGR--------QRYKCHDCGYSYSVEIkSTASPMS-----VKRQALQLYLEGLGFR 60
Cdd:NF033550   13 CPECgkPSRRVHDTGKrrirhlpIFGRpvylelrvRRFKCPECGKTFTEEL-PWARKRSritlrLEAAVLALLLELMSVA 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1137717711  61 SIGRFLGVSHVSVQKWIKKFGRELEDLKSENEISIVELDEmHTYIGNKKYcwIWIAVDRDGKRFID 126
Cdd:NF033550   92 AVARQLGVSWSTVWRILLRAVRRLLAKRDPRLPRVLGVDE-FALRKGHKY--VTVIVDLETGRVLD 154
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 37-80 1.17e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 39.06  E-value: 1.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1137717711  37 KSTASPMSVKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKF 80
Cdd:COG3415    19 KTKDAREARRLRAVLLLAEGLSVREIAERLGVSRSTVYRWLKRY 62
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 45-83 2.48e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 34.88  E-value: 2.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1137717711  45 VKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFGRE 83
Cdd:pfam13518   1 ERLKIVLLALEGESIKEAARLFGISRSTVYRWIRRYREG 39
Terminase_5 pfam06056
Putative ATPase subunit of terminase (gpP-like); This family of proteins are annotated as ...
 45-81 2.94e-03

Putative ATPase subunit of terminase (gpP-like); This family of proteins are annotated as ATPase subunits of phage terminase after. Terminases are viral proteins that are involved in packaging viral DNA into the capsid.


Pssm-ID: 428745 [Multi-domain]  Cd Length: 58  Bit Score: 35.05  E-value: 2.94e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1137717711  45 VKRQALQLYLEGLGFRSIGRFLGVSHVSVQKWIKKFG 81
Cdd:pfam06056   2 VRRQARFLYWQGYRPAEIAEMLGLKEATVYSWKQRDE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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