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Conserved domains on  [gi|1140785673|ref|WP_076646110|]
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MULTISPECIES: pimeloyl-ACP methyl ester esterase BioH [Vibrio]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 229394)

alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Abhydrolase super family cl21494
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ...
 11-256 6.68e-118

alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom.


The actual alignment was detected with superfamily member TIGR01738:

Pssm-ID: 473884 [Multi-domain]  Cd Length: 245  Bit Score: 337.17  E-value: 6.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  11 GQG-PDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQAIWVGWSLGGLVAT 89
Cdd:TIGR01738   1 GQGnVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLSLADMAEAIAAQAPDPAIWLGWSLGGLVAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  90 HMALHHSDYVSKLVTVASSPKFAAAKEpvlWR-GIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQLKQAV 168
Cdd:TIGR01738  81 HIAATHPDRVRALVTVASSPCFSARED---WPeGIKPDVLTGFQQQLSDDYQRTIERFLALQTLGTPTARQDARALKQTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 169 LSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQSSHAPFMTEADAF 248
Cdd:TIGR01738 158 LARPTPNVQVLQAGLEILATVDLRQPLQNISVPFLRLYGYLDGLVPAKVVPMLDKLAPHSELYIFAKAAHAPFLSHAEAF 237


                  ....*...
gi 1140785673 249 CSELVSFA 256
Cdd:TIGR01738 238 CALLVAFK 245
 
Name Accession Description Interval E-value
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 11-256 6.68e-118

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 337.17  E-value: 6.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  11 GQG-PDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQAIWVGWSLGGLVAT 89
Cdd:TIGR01738   1 GQGnVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLSLADMAEAIAAQAPDPAIWLGWSLGGLVAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  90 HMALHHSDYVSKLVTVASSPKFAAAKEpvlWR-GIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQLKQAV 168
Cdd:TIGR01738  81 HIAATHPDRVRALVTVASSPCFSARED---WPeGIKPDVLTGFQQQLSDDYQRTIERFLALQTLGTPTARQDARALKQTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 169 LSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQSSHAPFMTEADAF 248
Cdd:TIGR01738 158 LARPTPNVQVLQAGLEILATVDLRQPLQNISVPFLRLYGYLDGLVPAKVVPMLDKLAPHSELYIFAKAAHAPFLSHAEAF 237


                  ....*...
gi 1140785673 249 CSELVSFA 256
Cdd:TIGR01738 238 CALLVAFK 245
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
5-257 1.41e-96

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 283.45  E-value: 1.41e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   5 LYWHVSGQGP-DLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQAIWVGWSL 83
Cdd:PRK10349    4 IWWQTKGQGNvHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  84 GGLVATHMALHHSDYVSKLVTVASSPKFAAAKEpvlWRGIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQ 163
Cdd:PRK10349   84 GGLVASQIALTHPERVQALVTVASSPCFSARDE---WPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 164 LKQAVLSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQSSHAPFMT 243
Cdd:PRK10349  161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240

                         250
                  ....*....|....
gi 1140785673 244 EADAFCSELVSFAQ 257
Cdd:PRK10349  241 HPAEFCHLLVALKQ 254
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 5-257 6.51e-42

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 142.83  E-value: 6.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   5 LYWHVSG-QGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHC--------HAQDLEEIAQQLLVDapkQ 75
Cdd:COG0596    14 LHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPaggytlddLADDLAALLDALGLE---R 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  76 AIWVGWSLGGLVATHMALHHSDYVSKLVTVAsspkfaaakepvlwrgiqpnvlsafteqlvedfqttierfmalqamgsp 155
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPERVAGLVLVD------------------------------------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 156 sarqDVKQLKQAVLSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQ 235
Cdd:COG0596   122 ----EVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPG 197

                         250       260
                  ....*....|....*....|..
gi 1140785673 236 SSHAPFMTEADAFCSELVSFAQ 257
Cdd:COG0596   198 AGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 16-245 7.23e-29

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 109.52  E-value: 7.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  16 LVLVHGWGMNGAVWQQTVTAL-EADFRVHVVDLPGYGHS----------AHCHAQDLEEIAQQLLVDapkQAIWVGWSLG 84
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALaRDGFRVIALDLRGFGKSsrpkaqddyrTDDLAEDLEYILEALGLE---KVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  85 GLVATHMALHHSDYVSKLVTVASSPKFAaakEPVLWRGIQPNVLSAFTEQLVEDF-QTTIERFMALQAMGSPSARQDVKQ 163
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGALDPPH---ELDEADRFILALFPGFFDGFVADFaPNPLGRLVAKLLALLLLRLRLLKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 164 LKQAVLSRP---LPNPDSLLAGLKM----LSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQS 236
Cdd:pfam00561 157 LPLLNKRFPsgdYALAKSLVTGALLfietWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDA 236


                  ....*....
gi 1140785673 237 SHAPFMTEA 245
Cdd:pfam00561 237 GHFAFLEGP 245
 
Name Accession Description Interval E-value
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 11-256 6.68e-118

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 337.17  E-value: 6.68e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  11 GQG-PDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQAIWVGWSLGGLVAT 89
Cdd:TIGR01738   1 GQGnVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLSLADMAEAIAAQAPDPAIWLGWSLGGLVAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  90 HMALHHSDYVSKLVTVASSPKFAAAKEpvlWR-GIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQLKQAV 168
Cdd:TIGR01738  81 HIAATHPDRVRALVTVASSPCFSARED---WPeGIKPDVLTGFQQQLSDDYQRTIERFLALQTLGTPTARQDARALKQTL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 169 LSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQSSHAPFMTEADAF 248
Cdd:TIGR01738 158 LARPTPNVQVLQAGLEILATVDLRQPLQNISVPFLRLYGYLDGLVPAKVVPMLDKLAPHSELYIFAKAAHAPFLSHAEAF 237


                  ....*...
gi 1140785673 249 CSELVSFA 256
Cdd:TIGR01738 238 CALLVAFK 245
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
5-257 1.41e-96

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 283.45  E-value: 1.41e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   5 LYWHVSGQGP-DLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQAIWVGWSL 83
Cdd:PRK10349    4 IWWQTKGQGNvHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  84 GGLVATHMALHHSDYVSKLVTVASSPKFAAAKEpvlWRGIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQ 163
Cdd:PRK10349   84 GGLVASQIALTHPERVQALVTVASSPCFSARDE---WPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 164 LKQAVLSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQSSHAPFMT 243
Cdd:PRK10349  161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240

                         250
                  ....*....|....
gi 1140785673 244 EADAFCSELVSFAQ 257
Cdd:PRK10349  241 HPAEFCHLLVALKQ 254
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 5-257 6.51e-42

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 142.83  E-value: 6.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   5 LYWHVSG-QGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHC--------HAQDLEEIAQQLLVDapkQ 75
Cdd:COG0596    14 LHYREAGpDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPaggytlddLADDLAALLDALGLE---R 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  76 AIWVGWSLGGLVATHMALHHSDYVSKLVTVAsspkfaaakepvlwrgiqpnvlsafteqlvedfqttierfmalqamgsp 155
Cdd:COG0596    91 VVLVGHSMGGMVALELAARHPERVAGLVLVD------------------------------------------------- 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 156 sarqDVKQLKQAVLSRPLPNPDSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQ 235
Cdd:COG0596   122 ----EVLAALAEPLRRPGLAPEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPG 197

                         250       260
                  ....*....|....*....|..
gi 1140785673 236 SSHAPFMTEADAFCSELVSFAQ 257
Cdd:COG0596   198 AGHFPPLEQPEAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 16-245 7.23e-29

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 109.52  E-value: 7.23e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  16 LVLVHGWGMNGAVWQQTVTAL-EADFRVHVVDLPGYGHS----------AHCHAQDLEEIAQQLLVDapkQAIWVGWSLG 84
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPALaRDGFRVIALDLRGFGKSsrpkaqddyrTDDLAEDLEYILEALGLE---KVNLVGHSMG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  85 GLVATHMALHHSDYVSKLVTVASSPKFAaakEPVLWRGIQPNVLSAFTEQLVEDF-QTTIERFMALQAMGSPSARQDVKQ 163
Cdd:pfam00561  80 GLIALAYAAKYPDRVKALVLLGALDPPH---ELDEADRFILALFPGFFDGFVADFaPNPLGRLVAKLLALLLLRLRLLKA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 164 LKQAVLSRP---LPNPDSLLAGLKM----LSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQS 236
Cdd:pfam00561 157 LPLLNKRFPsgdYALAKSLVTGALLfietWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDA 236


                  ....*....
gi 1140785673 237 SHAPFMTEA 245
Cdd:pfam00561 237 GHFAFLEGP 245
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-255 3.66e-16

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 75.04  E-value: 3.66e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  13 GPDLVLVHGWGMNGAVWQQTVTAL-EADFRVHVVDLPGYGHSAHCH---------AQDLEEIAQQLLVDAPKQAIWVGWS 82
Cdd:COG2267    28 RGTVVLVHGLGEHSGRYAELAEALaAAGYAVLAFDLRGHGRSDGPRghvdsfddyVDDLRAALDALRARPGLPVVLLGHS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  83 LGGLVATHMALHHSDYVSKLvtVASSPKFAAakepvlwrgiqpnvlsafteqlvedfqttierfmalQAMGSPSARqdvk 162
Cdd:COG2267   108 MGGLIALLYAARYPDRVAGL--VLLAPAYRA------------------------------------DPLLGPSAR---- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 163 qlkqavlsrplpnpdsllaglkMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDL-DKALPHTEQYIFTQSSHAPF 241
Cdd:COG2267   146 ----------------------WLRALRLAEALARIDVPVLVLHGGADRVVPPEAARRLaARLSPDVELVLLPGARHELL 203

                         250
                  ....*....|....*
gi 1140785673 242 M-TEADAFCSELVSF 255
Cdd:COG2267   204 NePAREEVLAAILAW 218
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
17-258 1.17e-14

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 71.13  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  17 VLVHGWGMNGAVWQQTVTAL-EADFRVHVVDLPGYGHS----AHCHAQD----LEEIAQQLLVDAPKQAIwVGWSLGGLV 87
Cdd:COG1647    19 LLLHGFTGSPAEMRPLAEALaKAGYTVYAPRLPGHGTSpedlLKTTWEDwledVEEAYEILKAGYDKVIV-IGLSMGGLL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  88 ATHMALHHSDyVSKLVTVASSPKFAAakepvlWRGIQPNVLSAFTEQLvedfqttierfmalqaMGSPSARQDVKQLKQA 167
Cdd:COG1647    98 ALLLAARYPD-VAGLVLLSPALKIDD------PSAPLLPLLKYLARSL----------------RGIGSDIEDPEVAEYA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 168 VLSRPLPnpdSLLAGLKMLSDVdlREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHT--EQYIFTQSSHapFMT-- 243
Cdd:COG1647   155 YDRTPLR---ALAELQRLIREV--RRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkELVWLEDSGH--VITld 227

                         250
                  ....*....|....*.
gi 1140785673 244 -EADAFCSELVSFAQN 258
Cdd:COG1647   228 kDREEVAEEILDFLER 243
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 13-95 5.28e-13

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 66.40  E-value: 5.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  13 GPDLVLVHGWGMNGAVWQQTVTALeADFRVHVVDLPGYGHSAHCHAQDLEEIAQQL---LVDAPKQAIW-VGWSLGGLVA 88
Cdd:PRK11126    2 LPWLVFLHGLLGSGQDWQPVGEAL-PDYPRLYIDLPGHGGSAAISVDGFADVSRLLsqtLQSYNILPYWlVGYSLGGRIA 80


                  ....*..
gi 1140785673  89 THMALHH 95
Cdd:PRK11126   81 MYYACQG 87
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 16-107 1.07e-12

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 62.54  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  16 LVLVHGWGMNGAVWQQTVTALEAD-FRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAP-KQAIWVGWSLGGLVATHMAL 93
Cdd:COG1075     8 VVLVHGLGGSAASWAPLAPRLRAAgYPVYALNYPSTNGSIEDSAEQLAAFVDAVLAATGaEKVDLVGHSMGGLVARYYLK 87

                          90
                  ....*....|....*.
gi 1140785673  94 HHS--DYVSKLVTVAS 107
Cdd:COG1075    88 RLGgaAKVARVVTLGT 103
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 11-258 3.02e-12

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 65.74  E-value: 3.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  11 GQGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAH-CHAQDLEEIAQQLL--VDA--PKQAIWVGWSLGG 85
Cdd:PRK14875  129 GDGTPVVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASSKaVGAGSLDELAAAVLafLDAlgIERAHLVGHSMGG 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  86 LVATHMALHHSDYVSKLVTVASSpkfaaakepvlwrGIQPNVLSAFTEQLVE-----DFQTTIERFMALQAMGSPSARQD 160
Cdd:PRK14875  209 AVALRLAARAPQRVASLTLIAPA-------------GLGPEINGDYIDGFVAaesrrELKPVLELLFADPALVTRQMVED 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 161 VKQLKQAvlsrplpnpDSLLAGLKMLSD---------VDLREQLPQISVPMLRLYGRLDGLVPIKVAkdldKALPHTEQ- 230
Cdd:PRK14875  276 LLKYKRL---------DGVDDALRALADalfaggrqrVDLRDRLASLAIPVLVIWGEQDRIIPAAHA----QGLPDGVAv 342

                         250       260
                  ....*....|....*....|....*...
gi 1140785673 231 YIFTQSSHAPFMTEADAFCSELVSFAQN 258
Cdd:PRK14875  343 HVLPGAGHMPQMEAAADVNRLLAEFLGK 370
PLN02578 PLN02578
hydrolase
 9-240 2.33e-11

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 62.94  E-value: 2.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   9 VSGQGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAQDLEEIAQQLLVDAPKQ-----AIWVGWSL 83
Cdd:PLN02578   82 VQGEGLPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSDKALIEYDAMVWRDQVADFVKEvvkepAVLVGNSL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  84 GGLVATHMALHHSDYVSKLVTVASSPKFAAAKEP-------------------------------VLWRGIQPNVLSAFT 132
Cdd:PLN02578  162 GGFTALSTAVGYPELVAGVALLNSAGQFGSESREkeeaivveetvltrfvvkplkewfqrvvlgfLFWQAKQPSRIESVL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 133 EQLVEDfQTTIERFMaLQAMGSPSARQDVKQLKQAVLSRPLPNPdsllaglkmlSDVDLREQLPQISVPMLRLYGRLDGL 212
Cdd:PLN02578  242 KSVYKD-KSNVDDYL-VESITEPAADPNAGEVYYRLMSRFLFNQ----------SRYTLDSLLSKLSCPLLLLWGDLDPW 309

                         250       260
                  ....*....|....*....|....*...
gi 1140785673 213 VPIKVAKDLdKALPHTEQYIFTQSSHAP 240
Cdd:PLN02578  310 VGPAKAEKI-KAFYPDTTLVNLQAGHCP 336
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 16-228 1.77e-10

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 59.54  E-value: 1.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  16 LVLVHGWGMNGAVWQQTVTAL-EADFRVHVVDLPGYGHS--AHCHA-------QDLEEIAQQLLVDAPKQAIWV-GWSLG 84
Cdd:pfam12146   7 VVLVHGLGEHSGRYAHLADALaAQGFAVYAYDHRGHGRSdgKRGHVpsfddyvDDLDTFVDKIREEHPGLPLFLlGHSMG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  85 GLVATHMALHHSDYVSKLVTVAsspkfaaakePVLWrgIQPNVLSAFTEQLVEDFQTTIERfMALQAMGSPSARQD---- 160
Cdd:pfam12146  87 GLIAALYALRYPDKVDGLILSA----------PALK--IKPYLAPPILKLLAKLLGKLFPR-LRVPNNLLPDSLSRdpev 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1140785673 161 VKQLKQAVLSRPLPNPDSLLAGLKMLSDVdlREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHT 228
Cdd:pfam12146 154 VAAYAADPLVHGGISARTLYELLDAGERL--LRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGST 219
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 17-211 6.79e-10

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 59.10  E-value: 6.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   17 VLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHS---AHCHAQDLE-EIAQQLLVDA---------PKQAIWVGWSL 83
Cdd:PLN02980  1375 LFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSkiqNHAKETQTEpTLSVELVADLlykliehitPGKVTLVGYSM 1454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   84 GGLVATHMALHHSDYVSKLVTVASSP--------KFAAAKEPVLWRGIQPNVLSAFTE-----QLVEDFQTTiERFMALQ 150
Cdd:PLN02980  1455 GARIALYMALRFSDKIEGAVIISGSPglkdevarKIRSAKDDSRARMLIDHGLEIFLEnwysgELWKSLRNH-PHFNKIV 1533

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140785673  151 AmgSPSARQDVKQLKQavlsrplpnpdsLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDG 211
Cdd:PLN02980  1534 A--SRLLHKDVPSLAK------------LLSDLSIGRQPSLWEDLKQCDTPLLLVVGEKDV 1580
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 14-252 1.02e-09

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 58.00  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  14 PDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAH--CHAQDLEEiAQQLLVDAPKQ---------AIWVGWS 82
Cdd:PLN02894  106 PTLVMVHGYGASQGFFFRNFDALASRFRVIAIDQLGWGGSSRpdFTCKSTEE-TEAWFIDSFEEwrkaknlsnFILLGHS 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  83 LGGLVATHMALHHSDYVSKLVTVASS--PKFAAAKEPVL------WRGIQPNVL--SAFTEQ------------LVedFQ 140
Cdd:PLN02894  185 FGGYVAAKYALKHPEHVQHLILVGPAgfSSESDDKSEWLtkfratWKGAVLNHLweSNFTPQkiirglgpwgpnLV--RR 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 141 TTIERFMAlQAMGSPSARQDVKQLKQAVLSrPLPNPDSLLAGLKML------SDVDLREQLPQISVPMLRLYGRLDGLVP 214
Cdd:PLN02894  263 YTTARFGA-HSTGDILSEEESKLLTDYVYH-TLAAKASGELCLKYIfsfgafARKPLLESASEWKVPTTFIYGRHDWMNY 340

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1140785673 215 iKVAKDLDKALPH-TEQYIFTQSSHAPFMTEADAFCSEL 252
Cdd:PLN02894  341 -EGAVEARKRMKVpCEIIRVPQGGHFVFLDNPSGFHSAV 378
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 16-177 1.46e-09

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 56.33  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  16 LVLVHGWGMNGAVWQQtvtALEADFRVHVVDLPGYGHSAHCH-----AQDLEEIAQQLlvDAPKQAIWVGWSLGGLVATH 90
Cdd:pfam12697   1 VVLVHGAGLSAAPLAA---LLAAGVAVLAPDLPGHGSSSPPPldladLADLAALLDEL--GAARPVVLVGHSLGGAVALA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  91 MALHhsdyvSKLVTVASSPKFAAAKEPVLWRGIQPNVLSAFTEQLVEDFQTTIERFMALQAMGSPSARQDVKQLKQAVLS 170
Cdd:pfam12697  76 AAAA-----ALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPADAEWAAALARLAALLAAL 150


                  ....*..
gi 1140785673 171 RPLPNPD 177
Cdd:pfam12697 151 ALLPLAA 157
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 6-53 1.59e-07

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 51.28  E-value: 1.59e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140785673   6 YWHVSGQGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHS 53
Cdd:PLN02824   22 YQRAGTSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYS 69
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
14-169 2.36e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.40  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  14 PDLVLVHGWGMNGAV-WQQTVTAL-EADFRVHVVDLPGYGHSAHCHAQD--------LEEIAQQLLVDAPKQAIWvGWSL 83
Cdd:COG1506    24 PVVVYVHGGPGSRDDsFLPLAQALaSRGYAVLAPDYRGYGESAGDWGGDevddvlaaIDYLAARPYVDPDRIGIY-GHSY 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  84 GGLVATHMALHHSDYVSKLVTVASSPKFAAAKEPVLWrgiqpnvlsaFTEQLVEDFQTTIERFMALqamgSPSARqdVKQ 163
Cdd:COG1506   103 GGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTTRE----------YTERLMGGPWEDPEAYAAR----SPLAY--ADK 166


                  ....*.
gi 1140785673 164 LKQAVL 169
Cdd:COG1506   167 LKTPLL 172
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 9-240 5.13e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 40.98  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673   9 VSGQGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHS--AHCHAQDLEEIAQQLL--VD--APKQAIWVGWS 82
Cdd:PLN02679   84 VTSSGPPVLLVHGFGASIPHWRRNIGVLAKNYTVYAIDLLGFGASdkPPGFSYTMETWAELILdfLEevVQKPTVLIGNS 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  83 LGGLVATHMALHHS-DYVSKLVTVASSP-------------KFAAakePVLW--------RGIQP-------------NV 127
Cdd:PLN02679  164 VGSLACVIAASESTrDLVRGLVLLNCAGgmnnkavvddwriKLLL---PLLWlidfllkqRGIASalfnrvkqrdnlkNI 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673 128 LS-------AFTEQLVEDFQTTIERFMALQAMGSpsarqdvkqlkqAVLSRPLPNPDSLlaglkmlsdvdlreqLPQISV 200
Cdd:PLN02679  241 LLsvygnkeAVDDELVEIIRGPADDEGALDAFVS------------IVTGPPGPNPIKL---------------IPRISL 293

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1140785673 201 PMLRLYGRLDGLVPI-----KVAKDLDKALPHTEQYIFTQSSHAP 240
Cdd:PLN02679  294 PILVLWGDQDPFTPLdgpvgKYFSSLPSQLPNVTLYVLEGVGHCP 338
PRK05855 PRK05855
SDR family oxidoreductase;
13-55 1.89e-03

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 39.19  E-value: 1.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1140785673  13 GPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAH 55
Cdd:PRK05855   25 RPTVVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSSA 67
EntF2 COG3319
Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase ...
 10-92 2.13e-03

Thioesterase domain of type I polyketide synthase or non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442548 [Multi-domain]  Cd Length: 855  Bit Score: 39.30  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140785673  10 SGQGPDLVLVHGWGMNGAVWQQTVTALEADFRVHVVDLPGYGHSAHCHAqDLEEIAQQLLvdapkQAIW----------V 79
Cdd:COG3319   598 GGSGPPLFCVHPAGGNVLCYRPLARALGPDRPVYGLQAPGLDGGEPPPA-SVEEMAARYV-----EAIRavqpegpyhlL 671

                          90
                  ....*....|...
gi 1140785673  80 GWSLGGLVATHMA 92
Cdd:COG3319   672 GWSFGGLVAYEMA 684
Abhydrolase_5 pfam12695
Alpha/beta hydrolase family; This family contains a diverse range of alpha/beta hydrolase ...
 177-241 3.29e-03

Alpha/beta hydrolase family; This family contains a diverse range of alpha/beta hydrolase enzymes.


Pssm-ID: 315383 [Multi-domain]  Cd Length: 164  Bit Score: 37.43  E-value: 3.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1140785673 177 DSLLAGLKMLSDVDLREQLPQISVPMLRLYGRLDGLVPIKVAKDLDKALPHTEQYIFTQS-SHAPF 241
Cdd:pfam12695  78 NELIKGVVFLASYPDKDSLSNLSFPVLSIYGTNDGVLNWKSYQKNKQFLPKDTTYVSIEGgNHAGF 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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