NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1140790947|ref|WP_076651054|]
View 

MULTISPECIES: 4Fe-4S dicluster domain-containing protein [unclassified Vibrio]

Protein Classification

PreA and DMSOR_beta-like domain-containing protein( domain architecture ID 11439189)

PreA and DMSOR_beta-like domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NapF COG1145
Ferredoxin [Energy production and conversion];
401-471 6.82e-13

Ferredoxin [Energy production and conversion];


:

Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 68.60  E-value: 6.82e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 401 IVELPSNAPYGTVSCESKGCTLCMSCVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:COG1145   165 EEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVVDPDKCIGCGACVKVCPVGAISLEPK 235
HdrA super family cl34141
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
172-233 5.35e-12

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


The actual alignment was detected with superfamily member COG1148:

Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 68.35  E-value: 5.35e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 172 DTDLCAhssrgvkGCERCVDACPAGALSsegsDKTGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG1148   494 DPEKCT-------GCGRCVEVCPYGAIS----IDEKGVAEVNPALCKGCGTCAAACPSGAIS 544
PRK12387 super family cl32760
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 420-535 5.81e-10

formate hydrogenlyase complex iron-sulfur subunit; Provisional


The actual alignment was detected with superfamily member PRK12387:

Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 58.51  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRAL--HTDGASPSLK--FVEQDCIQCGLCEKACPENVLTLTPRMN---WVKEE-RQKAVViheeKAA 491
Cdd:PRK12387   40 CIGCAACVNACPSNALtvETDLATGELAweFNLGRCIFCGRCEEVCPTAAIKLSQEFElavWKKEDlLQQSEF----ALC 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1140790947 492 ECIRCHKPFAPQSMIDMLQNKLRGHSHFSDEAAINRIAMCEDCR 535
Cdd:PRK12387  116 NCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECK 159
 
Name Accession Description Interval E-value
NapF COG1145
Ferredoxin [Energy production and conversion];
401-471 6.82e-13

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 68.60  E-value: 6.82e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 401 IVELPSNAPYGTVSCESKGCTLCMSCVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:COG1145   165 EEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVVDPDKCIGCGACVKVCPVGAISLEPK 235
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 417-496 4.53e-12

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 63.18  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 417 SKGCTLCMSCVAVCPTRALH--TDGASPSLKFVEQD-CIQCGLCEKACPENVLTLTPRMNWVKEERQKAVVIHEekaaEC 493
Cdd:cd10549     5 PEKCIGCGICVKACPTDAIElgPNGAIARGPEIDEDkCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEE----KC 80


                  ...
gi 1140790947 494 IRC 496
Cdd:cd10549    81 IGC 83
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
172-233 5.35e-12

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 68.35  E-value: 5.35e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 172 DTDLCAhssrgvkGCERCVDACPAGALSsegsDKTGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG1148   494 DPEKCT-------GCGRCVEVCPYGAIS----IDEKGVAEVNPALCKGCGTCAAACPSGAIS 544
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 420-535 5.81e-10

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 58.51  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRAL--HTDGASPSLK--FVEQDCIQCGLCEKACPENVLTLTPRMN---WVKEE-RQKAVViheeKAA 491
Cdd:PRK12387   40 CIGCAACVNACPSNALtvETDLATGELAweFNLGRCIFCGRCEEVCPTAAIKLSQEFElavWKKEDlLQQSEF----ALC 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1140790947 492 ECIRCHKPFAPQSMIDMLQNKLRGHSHFSDEAAINRIAMCEDCR 535
Cdd:PRK12387  116 NCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECK 159
napH PRK09477
quinol dehydrogenase membrane component; Provisional
 420-473 6.24e-09

quinol dehydrogenase membrane component; Provisional


Pssm-ID: 236535 [Multi-domain]  Cd Length: 271  Bit Score: 57.22  E-value: 6.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTR-----ALHtdGASPSLKFVEQDCIQCGLCEKACPENVLTLTPRMN 473
Cdd:PRK09477  210 CTRCMDCFHVCPEPqvlrpPLK--GKQSPSQVTSGDCITCGRCIDVCSEDVFNFTIRFK 266
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 411-534 6.69e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 53.84  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 411 GTVSCESkGCTLCMSCVAVCPTRALHtdGASPSL-KFVEQDCIQCGLCEKACPENVLTLTPR------MNWVKeerQKAV 483
Cdd:COG2878   131 GPKGCEY-GCIGCGDCIKACPFDAIV--GAAKGMhTVDEDKCTGCGLCVEACPVDCIEMVPVsptvvvSSWDK---GKAV 204

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 484 viheEKAAECIRCHKPFAPQSMIDMLQNKLRGHshfsDEAAINRIAMCEDC 534
Cdd:COG2878   205 ----RKVVGCIGLCCKKCCPAAAITVNNLAAII----DYKKCTCCGCCEKC 247
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 420-465 9.86e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 48.68  E-value: 9.86e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGAS-----PSLKFVEQDCIQCGLCEKACPENV 465
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGekkgtKTVVIDPERCVGCGACVAVCPTGA 51
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 185-232 1.28e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 50.47  E-value: 1.28e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 185 GCERCVDACPAGALSSEGSDKTGHKIEINPYLCQGVGTCATSCPTEAI 232
Cdd:cd10549    10 GCGICVKACPTDAIELGPNGAIARGPEIDEDKCVFCGACVEVCPTGAI 57
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 419-480 1.80e-07

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 50.11  E-value: 1.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 419 GCTLCmscVAVCPTRALH-----TDGASPSLKFVEQD---CIQCGLCEKACPENVLTLTPRMNWVKEERQ 480
Cdd:TIGR01971  47 GCTLC---AAVCPADAIRvvpaeGEDGKRRLKFYEINfgrCIFCGLCEEACPTDAIVLTPEFELATYTRS 113
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 185-231 1.87e-07

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 47.91  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 185 GCERCVDACPAGALS--SEGSDKTGHKIEINPYLCQGVGTCATSCPTEA 231
Cdd:pfam12838   3 GCGACVAACPVGAITldEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 184-235 3.16e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 43.17  E-value: 3.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1140790947 184 KGCERCVDACPAGALS--SEGSDKTGHKIEI-NPYLCQGVGTCATSCPTEAISYA 235
Cdd:PRK09626   19 KACDICVSVCPAGVLAmrIDPHAVLGKMIKVvHPESCIGCRECELHCPDFAIYVA 73
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 451-496 1.68e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.43  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1140790947 451 CIQCGLCEKACPENVLTLTPRMNwvkEERQKAVVIHEEKAAECIRC 496
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGE---KKGTKTVVIDPERCVGCGAC 43
FrhG TIGR03294
coenzyme F420 hydrogenase, subunit gamma; This model represents that clade of F420-dependent ...
 194-232 2.50e-03

coenzyme F420 hydrogenase, subunit gamma; This model represents that clade of F420-dependent hydrogenases (FRH) beta subunits found exclusively and universally in methanogenic archaea. This protein contains two 4Fe-4S cluster binding domains (pfam00037) and scores above the trusted cutoff to model pfam01058 for the "NADH ubiquinone oxidoreductase, 20 Kd subunit" family.


Pssm-ID: 132337 [Multi-domain]  Cd Length: 228  Bit Score: 39.84  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1140790947 194 PAGALSSEGSDKTGHKIE---INPYLCQGVGTCATSCPTEAI 232
Cdd:TIGR03294 150 PLAALAEEGTEACGCDLMtkvVNQGLCMGCGTCAAACPTRAI 191
 
Name Accession Description Interval E-value
NapF COG1145
Ferredoxin [Energy production and conversion];
401-471 6.82e-13

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 68.60  E-value: 6.82e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 401 IVELPSNAPYGTVSCESKGCTLCMSCVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:COG1145   165 EEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRLKDGKPQIVVDPDKCIGCGACVKVCPVGAISLEPK 235
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 417-496 4.53e-12

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 63.18  E-value: 4.53e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 417 SKGCTLCMSCVAVCPTRALH--TDGASPSLKFVEQD-CIQCGLCEKACPENVLTLTPRMNWVKEERQKAVVIHEekaaEC 493
Cdd:cd10549     5 PEKCIGCGICVKACPTDAIElgPNGAIARGPEIDEDkCVFCGACVEVCPTGAIELTPEGKEYVPKEKEAEIDEE----KC 80


                  ...
gi 1140790947 494 IRC 496
Cdd:cd10549    81 IGC 83
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
172-233 5.35e-12

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 68.35  E-value: 5.35e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 172 DTDLCAhssrgvkGCERCVDACPAGALSsegsDKTGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG1148   494 DPEKCT-------GCGRCVEVCPYGAIS----IDEKGVAEVNPALCKGCGTCAAACPSGAIS 544
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 168-241 4.42e-11

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 58.57  E-value: 4.42e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1140790947 168 FFRLDTDLCahssrgvKGCERCVDACPAGALssEGSDKTGHKIEINPYLCQGVGTCATSCPTEAISYALPNPDD 241
Cdd:COG1146     2 MPVIDTDKC-------IGCGACVEVCPVDVL--ELDEEGKKALVINPEECIGCGACELVCPVGAITVEDDEPEE 66
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 397-496 5.84e-11

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 60.10  E-value: 5.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 397 PVENIvELPSNAPYGTVSCESKG-CTLCMSCVAVCPTRALHTDGASPSLKFV-------EQDCIQCGLCEKACPENVLTL 468
Cdd:cd10549    19 PTDAI-ELGPNGAIARGPEIDEDkCVFCGACVEVCPTGAIELTPEGKEYVPKekeaeidEEKCIGCGLCVKVCPVDAITL 97

                          90       100
                  ....*....|....*....|....*...
gi 1140790947 469 tprmnwvkeERQKAVVIHEEKaaeCIRC 496
Cdd:cd10549    98 ---------EDELEIVIDKEK---CIGC 113
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 167-234 7.52e-11

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 57.82  E-value: 7.52e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1140790947 167 KFFRLDTDLCahssrgvKGCERCVDACPAGALSSEGsdktGHKIEINPYLCQGVGTCATSCPTEAISY 234
Cdd:COG1149     4 KIPVIDEEKC-------IGCGLCVEVCPEGAIKLDD----GGAPVVDPDLCTGCGACVGVCPTGAITL 60
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 420-470 1.40e-10

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 57.06  E-value: 1.40e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGASPSLKFV--EQDCIQCGLCEKACPENVLTLTP 470
Cdd:COG1143     4 CIGCGLCVRVCPVDAITIEDGEPGKVYVidPDKCIGCGLCVEVCPTGAISMTP 56
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
172-248 2.36e-10

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 56.66  E-value: 2.36e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 172 DTDLCahssrgvKGCERCVDACPAGALSSEGsdktgHKIEINPYLCQGVGTCATSCPTEAISyalPNPDDTQKFIER 248
Cdd:COG2768     9 DEEKC-------IGCGACVKVCPVGAISIED-----GKAVIDPEKCIGCGACIEVCPVGAIK---IEWEEDEEFQEK 70
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 169-240 5.28e-10

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 55.82  E-value: 5.28e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 169 FRLDTDLCahssrgvKGCERCVDACPAGALSSEGSdktghKIEINPYLCQGVGTCATSCPTEAISYALPNPD 240
Cdd:COG4231    17 YVIDEDKC-------TGCGACVKVCPADAIEEGDG-----KAVIDPDLCIGCGSCVQVCPVDAIKLEKRVPE 76
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 420-535 5.81e-10

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 58.51  E-value: 5.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRAL--HTDGASPSLK--FVEQDCIQCGLCEKACPENVLTLTPRMN---WVKEE-RQKAVViheeKAA 491
Cdd:PRK12387   40 CIGCAACVNACPSNALtvETDLATGELAweFNLGRCIFCGRCEEVCPTAAIKLSQEFElavWKKEDlLQQSEF----ALC 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1140790947 492 ECIRCHKPFAPQSMIDMLQNKLRGHSHFSDEAAINRIAMCEDCR 535
Cdd:PRK12387  116 NCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECK 159
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 420-467 1.23e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 54.67  E-value: 1.23e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGasPSLKFVEQDCIQCGLCEKACPENVLT 467
Cdd:COG2221    17 CIGCGLCVAVCPTGAISLDD--GKLVIDEEKCIGCGACIRVCPTGAIK 62
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 170-237 1.44e-09

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 54.29  E-value: 1.44e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1140790947 170 RLDTDLCahssrgvKGCERCVDACPAGALSSEGsdktgHKIEINPYLCQGVGTCATSCPTEAISYALP 237
Cdd:COG2221    11 KIDEEKC-------IGCGLCVAVCPTGAISLDD-----GKLVIDEEKCIGCGACIRVCPTGAIKGEKP 66
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
420-471 2.14e-09

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 58.54  E-value: 2.14e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTralhtdGASPSLKFVEQ-DCIQCGLCEKACPENVLTLTPR 471
Cdd:COG0348   212 CIDCGLCVKVCPM------GIDIRKGEINQsECINCGRCIDACPKDAIRFSSR 258
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 420-471 2.49e-09

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 53.58  E-value: 2.49e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRAL-HTDGASPslKFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:COG1149    13 CIGCGLCVEVCPEGAIkLDDGGAP--VVDPDLCTGCGACVGVCPTGAITLEER 63
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 420-471 6.17e-09

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 52.40  E-value: 6.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGASPSLKFVEQD-CIQCGLCEKACPENVLTLTPR 471
Cdd:COG1146    10 CIGCGACVEVCPVDVLELDEEGKKALVINPEeCIGCGACELVCPVGAITVEDD 62
napH PRK09477
quinol dehydrogenase membrane component; Provisional
 420-473 6.24e-09

quinol dehydrogenase membrane component; Provisional


Pssm-ID: 236535 [Multi-domain]  Cd Length: 271  Bit Score: 57.22  E-value: 6.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTR-----ALHtdGASPSLKFVEQDCIQCGLCEKACPENVLTLTPRMN 473
Cdd:PRK09477  210 CTRCMDCFHVCPEPqvlrpPLK--GKQSPSQVTSGDCITCGRCIDVCSEDVFNFTIRFK 266
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 420-474 4.19e-08

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 52.25  E-value: 4.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 420 CTLCMSCVAVCPTRALHT-DGASPSLKFVEQDCIQCGLCEKACPENVLTLTPRMNW 474
Cdd:cd10564    15 CTRCGDCVEACPEGIIVRgDGGFPELDFSRGECTFCGACAEACPEGALDPAREAPW 70
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 411-534 6.69e-08

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 53.84  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 411 GTVSCESkGCTLCMSCVAVCPTRALHtdGASPSL-KFVEQDCIQCGLCEKACPENVLTLTPR------MNWVKeerQKAV 483
Cdd:COG2878   131 GPKGCEY-GCIGCGDCIKACPFDAIV--GAAKGMhTVDEDKCTGCGLCVEACPVDCIEMVPVsptvvvSSWDK---GKAV 204

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 484 viheEKAAECIRCHKPFAPQSMIDMLQNKLRGHshfsDEAAINRIAMCEDC 534
Cdd:COG2878   205 ----RKVVGCIGLCCKKCCPAAAITVNNLAAII----DYKKCTCCGCCEKC 247
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 421-497 8.66e-08

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 52.53  E-value: 8.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 421 TLCM-----SCVAVCPTRALHT--DGaspslkFVEQD---CIQCGLCEKACPENVltltPRMNWVKEERQKAVVIHEEKA 490
Cdd:cd10551    51 VLCNhcenpPCVKVCPTGATYKreDG------IVLVDydkCIGCRYCMAACPYGA----RYFNPEEPHEFGEVPVRPKGV 120


                  ....*...
gi 1140790947 491 AE-CIRCH 497
Cdd:cd10551   121 VEkCTFCY 128
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 420-465 9.86e-08

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 48.68  E-value: 9.86e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGAS-----PSLKFVEQDCIQCGLCEKACPENV 465
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGekkgtKTVVIDPERCVGCGACVAVCPTGA 51
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 171-233 1.10e-07

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 49.28  E-value: 1.10e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 171 LDTDLCahssrgvKGCERCVDACPAGALSSEGsdktGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG1144    27 VDEDKC-------IGCGLCWIVCPDGAIRVDD----GKYYGIDYDYCKGCGICAEVCPVKAIE 78
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 185-232 1.28e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 50.47  E-value: 1.28e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 185 GCERCVDACPAGALSSEGSDKTGHKIEINPYLCQGVGTCATSCPTEAI 232
Cdd:cd10549    10 GCGICVKACPTDAIELGPNGAIARGPEIDEDKCVFCGACVEVCPTGAI 57
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 185-233 1.60e-07

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 48.59  E-value: 1.60e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 185 GCERCVDACPAGALSSEGsDKTGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG1143     6 GCGLCVRVCPVDAITIED-GEPGKVYVIDPDKCIGCGLCVEVCPTGAIS 53
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 419-480 1.80e-07

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 50.11  E-value: 1.80e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 419 GCTLCmscVAVCPTRALH-----TDGASPSLKFVEQD---CIQCGLCEKACPENVLTLTPRMNWVKEERQ 480
Cdd:TIGR01971  47 GCTLC---AAVCPADAIRvvpaeGEDGKRRLKFYEINfgrCIFCGLCEEACPTDAIVLTPEFELATYTRS 113
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 185-231 1.87e-07

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 47.91  E-value: 1.87e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 185 GCERCVDACPAGALS--SEGSDKTGHKIEINPYLCQGVGTCATSCPTEA 231
Cdd:pfam12838   3 GCGACVAACPVGAITldEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
Fer4_9 pfam13187
4Fe-4S dicluster domain;
420-466 1.97e-07

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 47.55  E-value: 1.97e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTRA--LHTDGASPSLKFVEQDCIQCGLCEKACPENVL 466
Cdd:pfam13187   2 CTGCGACVAACPAGAivPDLVGQTIRGDIAGLACIGCGACVDACPRGAI 50
PRK13795 PRK13795
hypothetical protein; Provisional
 420-462 2.39e-07

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 53.46  E-value: 2.39e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACP 462
Cdd:PRK13795  583 CVGCGVCVGACPTGAIRIEEGKRKISVDEEKCIHCGKCTEVCP 625
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 185-234 2.67e-07

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 49.70  E-value: 2.67e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1140790947 185 GCERCVDACPAGALS----SEGSDKTGHKIEINPYLCQGVGTCATSCPTEAISY 234
Cdd:cd10549    44 FCGACVEVCPTGAIEltpeGKEYVPKEKEAEIDEEKCIGCGLCVKVCPVDAITL 97
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 411-468 2.71e-07

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 49.64  E-value: 2.71e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 411 GTVSCESKGCTLCMSCVAVCPTRAL--HTDGASPSlkfveqDCIQCGLCEKACPENVLTL 468
Cdd:cd16372    70 GVVMINKKLCVGCLMCVGFCPEGAMfkHEDYPEPF------KCIACGICVKACPTGALEL 123
NapF COG1145
Ferredoxin [Energy production and conversion];
172-235 4.35e-07

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 51.26  E-value: 4.35e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1140790947 172 DTDLCahssrgvKGCERCVDACPAGALSSegsDKTGHKIEINPYLCQGVGTCATSCPTEAISYA 235
Cdd:COG1145   180 DAEKC-------IGCGLCVKVCPTGAIRL---KDGKPQIVVDPDKCIGCGACVKVCPVGAISLE 233
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
420-479 1.23e-06

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 46.26  E-value: 1.23e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGasPSLKFVEQDCIQCGLCEKACPENVLTLTPRMNWVKEER 479
Cdd:COG2768    13 CIGCGACVKVCPVGAISIED--GKAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEEFQEK 70
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
184-247 1.28e-06

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 50.79  E-value: 1.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1140790947 184 KGCERCVDACPAGALSSEGsdktgHKIEINPYLCQGVGTCATSCPTEAISYAlpnpDDTQKFIE 247
Cdd:COG4624    94 KNCYPCVRACPVKAIKVDD-----GKAEIDEEKCISCGQCVAVCPFGAITEK----SDIEKVKK 148
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
420-480 1.36e-06

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 48.34  E-value: 1.36e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRAL------HTDGAspslKFVEQ---D---CIQCGLCEKACPENVLTLTPRMNWVKEERQ 480
Cdd:PRK05888   60 CIACKLCAAICPADAItieaaeREDGR----RRTTRydiNfgrCIFCGFCEEACPTDAIVETPDFELATETRE 128
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 420-471 1.54e-06

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 46.20  E-value: 1.54e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPTRALH-TDGASPSlkFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:COG1144    32 CIGCGLCWIVCPDGAIRvDDGKYYG--IDYDYCKGCGICAEVCPVKAIEMVPE 82
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 186-236 1.69e-06

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 47.62  E-value: 1.69e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 186 CERCVDACPAGALSSEGSDKTGHKIEINPyLC---QGVG--TCATSCPTEAISYAL 236
Cdd:cd10564    50 CGACAEACPEGALDPAREAPWPLRAEIGD-SClalQGVEcrSCQDACPTQAIRFRP 104
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 420-468 2.09e-06

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 45.42  E-value: 2.09e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGasPSLKFVEQDCIQCGLCEKACPENVLTL 468
Cdd:COG4231    24 CTGCGACVKVCPADAIEEGD--GKAVIDPDLCIGCGSCVQVCPVDAIKL 70
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
411-471 2.14e-06

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 49.55  E-value: 2.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 411 GTVSCeSKGCTLCMSCVAVCPTRALHTDgasPSLKFVEQD-CIQCGLCEKACPENVLTLTPR 471
Cdd:PRK07118  133 GPKGC-SYGCLGLGSCVAACPFDAIHIE---NGLPVVDEDkCTGCGACVKACPRNVIELIPK 190
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 151-234 2.76e-06

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 46.62  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 151 EALEEIPTLMGTFDKPKFFRLDTDLCahssrgvKGCERCVDACPAGALSSEgsdkTGHKIEINPYLCQGVGTCATSCPTE 230
Cdd:cd10549    55 GAIELTPEGKEYVPKEKEAEIDEEKC-------IGCGLCVKVCPVDAITLE----DELEIVIDKEKCIGCGICAEVCPVN 123


                  ....
gi 1140790947 231 AISY 234
Cdd:cd10549   124 AIKL 127
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 447-497 4.12e-06

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 44.31  E-value: 4.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 447 VEQDCIQCGLCEKACPENVLTLtprmnwvKEERQKAVVIHEEkaaECIRCH 497
Cdd:COG1146     6 DTDKCIGCGACVEVCPVDVLEL-------DEEGKKALVINPE---ECIGCG 46
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 426-481 4.18e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 46.42  E-value: 4.18e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 426 CVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACPENVltltPRMNWVKEERQK 481
Cdd:cd10550    57 CVEACPVGAISRDEETGAVVVDEDKCIGCGMCVEACPFGA----IRVDPETGKAIK 108
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 186-234 7.37e-06

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 45.84  E-value: 7.37e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 186 CE--RCVDACPAGALSSegsDKTGHkIEINPYLCQGVGTCATSCPTEAISY 234
Cdd:cd04410    53 CEdpPCVKACPTGAIYK---DEDGI-VLIDEDKCIGCGSCVEACPYGAIVF 99
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 419-471 1.13e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 45.31  E-value: 1.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 419 GCTLCMSCVAVCPTRALHTDGASP-SLKF-VEQDC-----IQCGLCEKACPENVLTLTPR 471
Cdd:cd10564    46 ECTFCGACAEACPEGALDPAREAPwPLRAeIGDSClalqgVECRSCQDACPTQAIRFRPR 105
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 418-462 1.18e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 45.32  E-value: 1.18e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1140790947 418 KGCTLCMSCVAVCPTRALHTDGASPSLK--FVEQDCIQCGLCEKACP 462
Cdd:cd16373    97 QGGTDCGVCVEACPTEAIAIVLEDDVLRpvVDEDKCVGCGLCEYVCP 143
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 448-496 1.24e-05

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 43.20  E-value: 1.24e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 448 EQDCIQCGLCEKACPENVLTLTPrmnwvkEERQKAVVIHEEKaaeCIRC 496
Cdd:COG1143     1 EDKCIGCGLCVRVCPVDAITIED------GEPGKVYVIDPDK---CIGC 40
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 421-476 1.72e-05

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 45.71  E-value: 1.72e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 421 TLCM-----SCVAVCPTRALH--TDGAspslkfVEQD---CIQCGLCEKACPENVltltPRMNWVK 476
Cdd:COG0437    58 VLCNhcddpPCVKVCPTGATYkrEDGI------VLVDydkCIGCRYCVAACPYGA----PRFNPET 113
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 420-535 1.85e-05

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 45.51  E-value: 1.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRAL--HTD---GASPSLKFVEQdCIQCGLCEKACPENVLTLTprmnwvkEERQKAVVIHEE------ 488
Cdd:PRK08222   40 CIACGACTCACPANALtiQTDdqqNSRTWQLYLGR-CIYCGRCEEVCPTRAIQLT-------NNFELTVTNKADlytrat 111

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1140790947 489 -KAAECIRCHKPFAPQSMIDMLQNKL--RGHSHFSDEAAINRIAMCEDCR 535
Cdd:PRK08222  112 fHLQRCSRCERPFAPQKTVALAAELLaqQQNAPQNREMLRAQASVCPECK 161
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
412-462 1.86e-05

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 47.33  E-value: 1.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 412 TVSCESKgCTLCMSCVAVCPTRALHTDGASPSLkfVEQDCIQCGLCEKACP 462
Cdd:COG4624    86 IIRDKEK-CKNCYPCVRACPVKAIKVDDGKAEI--DEEKCISCGQCVAVCP 133
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 426-462 2.20e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 44.48  E-value: 2.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1140790947 426 CVAVCPTRALH--TDGAspslkfVEQD---CIQCGLCEKACP 462
Cdd:cd16371    62 CVKVCPTGAITkrEDGI------VVVDqdkCIGCGYCVWACP 97
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 444-498 2.54e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 43.92  E-value: 2.54e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1140790947 444 LKFVEQDCIQCGLCEKACPENVLTLTPrmnwvKEERQKAVVIHEEKaaeCIRCHK 498
Cdd:cd10549     1 LKYDPEKCIGCGICVKACPTDAIELGP-----NGAIARGPEIDEDK---CVFCGA 47
SIMIBI_bact_arch cd03110
bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily ...
 171-233 2.70e-05

bacterial and archaeal subfamily of SIMIBI; Uncharacterized bacterial and archaeal subfamily of SIMIBI superfamily. Proteins in this superfamily contain an ATP-binding domain and use energy from hydrolysis of ATP to transfer electron or ion. The specific function of this family is unknown.


Pssm-ID: 349764 [Multi-domain]  Cd Length: 246  Bit Score: 45.84  E-value: 2.70e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 171 LDTDLCAhssrgvkGCERCVDACPAGALSSEGSdktghKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:cd03110    61 IDQEKCI-------RCGNCERVCKFGAILEFFQ-----KLIVDESLCEGCGACVIICPRGAIY 111
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 151-233 2.83e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 43.86  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 151 EALEEIPTLMGTFDKPKFFRLDTDLCAhssrgvkGCERCVDACPAGALSSegsdktgHKIEINPYLCQGVGTCATSCPTE 230
Cdd:cd16372    54 ECIDVCPTGAITRDANGVVMINKKLCV-------GCLMCVGFCPEGAMFK-------HEDYPEPFKCIACGICVKACPTG 119


                  ...
gi 1140790947 231 AIS 233
Cdd:cd16372   120 ALE 122
oorD PRK09626
2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed
 184-235 3.16e-05

2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed


Pssm-ID: 236597 [Multi-domain]  Cd Length: 103  Bit Score: 43.17  E-value: 3.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1140790947 184 KGCERCVDACPAGALS--SEGSDKTGHKIEI-NPYLCQGVGTCATSCPTEAISYA 235
Cdd:PRK09626   19 KACDICVSVCPAGVLAmrIDPHAVLGKMIKVvHPESCIGCRECELHCPDFAIYVA 73
Fer4_18 pfam13746
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 420-461 3.71e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404610 [Multi-domain]  Cd Length: 114  Bit Score: 43.16  E-value: 3.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1140790947 420 CTLCMSCVAVCPTralHTDgaspSLKFVEQDCIQCGLCEKAC 461
Cdd:pfam13746  61 CIDCESCVQVCPT---GID----IRKGLQLECINCGLCIDAC 95
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 170-228 3.73e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 41.47  E-value: 3.73e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 170 RLDTDLCahssrgvKGCERCVDACPAGALSSEGSDKTGH--KIEINPYLCQGVGTCATSCP 228
Cdd:pfam13237   3 VIDPDKC-------IGCGRCTAACPAGLTRVGAIVERLEgeAVRIGVWKCIGCGACVEACP 56
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 416-462 5.06e-05

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 41.08  E-value: 5.06e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 416 ESKGCTLCMSCVAVCPTRALHtDGASPSLKFVEQ------DCIQCGLCEKACP 462
Cdd:pfam13237   5 DPDKCIGCGRCTAACPAGLTR-VGAIVERLEGEAvrigvwKCIGCGACVEACP 56
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 420-469 7.68e-05

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 42.77  E-value: 7.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 420 CTLCMSCVAVCPTRALH-TDGASPSlkfVEQD-CIQCGLCEKACPENVLTLT 469
Cdd:cd10549    80 CIGCGLCVKVCPVDAITlEDELEIV---IDKEkCIGCGICAEVCPVNAIKLV 128
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 451-496 1.68e-04

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 39.43  E-value: 1.68e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1140790947 451 CIQCGLCEKACPENVLTLTPRMNwvkEERQKAVVIHEEKAAECIRC 496
Cdd:pfam12838   1 CIGCGACVAACPVGAITLDEVGE---KKGTKTVVIDPERCVGCGAC 43
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 411-468 1.69e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 41.49  E-value: 1.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 411 GTVSCESKGCTLCMSCVAVCPTRALHTDgaspslkfvEQD-----CIQCGLCEKACPENVLTL 468
Cdd:cd16370    76 GGVVLDKEKCIGCGNCVKACIVGAIFWD---------EETnkpiiCIHCGYCARYCPHDVLAM 129
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
447-496 2.05e-04

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 39.71  E-value: 2.05e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1140790947 447 VEQDCIQCGLCEKACPENVLTLTprmnwvkeerQKAVVIHEEKaaeCIRC 496
Cdd:COG2768     9 DEEKCIGCGACVKVCPVGAISIE----------DGKAVIDPEK---CIGC 45
PRK06273 PRK06273
ferredoxin; Provisional
 442-502 2.26e-04

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 42.00  E-value: 2.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 442 PSLKFVEQDCIQCGLCEKACPENVLTLTP------RMNWVKEERQKavvIHEEKAAECIRCHKpFAP 502
Cdd:PRK06273   42 LPKKVFEELCIGCGGCANVCPTKAIEMIPvepvkiTEGYVKTKIPK---IDYEKCVYCLYCHD-FCP 104
PRK10194 PRK10194
ferredoxin-type protein NapF;
186-233 2.29e-04

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 41.93  E-value: 2.29e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 186 CERCVDACPAGALSSEGSDKTGHKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:PRK10194  109 CRRCQDSCEPMAIIFRPTLSGIYQPQLNSQLCNGCGACAASCPVSAIT 156
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 186-237 2.31e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 41.46  E-value: 2.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 186 CERCVDACPAGALSSEGSDKTGHKIEINPYLCQGVGTCATSCPTEAISYALP 237
Cdd:cd10564    88 CRSCQDACPTQAIRFRPRLGGIALPELDADACTGCGACVSVCPVGAITLTPL 139
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 420-465 2.39e-04

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 39.37  E-value: 2.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTRALHTDG-ASPSLKF----VEQ--------DCIQCGLCEKACPENV 465
Cdd:pfam13534   2 CIQCGCCVDECPRYLLNGDEpKKLMRAAylgdLEElqankvanLCSECGLCEYACPMGL 60
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
426-462 3.01e-04

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 41.18  E-value: 3.01e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1140790947 426 CVAVCPTRALHTDGASPslKFVEQDCIQCGLCEKACP 462
Cdd:COG1142    60 CAEVCPVGAITRDDGAV--VVDEEKCIGCGLCVLACP 94
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
185-239 3.29e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 42.61  E-value: 3.29e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1140790947 185 GCERCVDACPAGALSSEGSdktghKIEINPYLCQGVGTCATSCPTEAISYALPNP 239
Cdd:PRK07118  217 GCGKCVKACPAGAITMENN-----LAVIDQEKCTSCGKCVEKCPTKAIRILNKPP 266
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 445-496 3.49e-04

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 39.26  E-value: 3.49e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 445 KFVEQDCIQCGLCEKACPENVLTLtprmnwvkeeRQKAVVIHEEKaaeCIRC 496
Cdd:COG2221    11 KIDEEKCIGCGLCVAVCPTGAISL----------DDGKLVIDEEK---CIGC 49
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 414-471 3.95e-04

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 40.69  E-value: 3.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 414 SCESKGCTLCMSCVAVCPTRALH---TDGASPSLKFVEQDCIQCGLCEKACPENVLTLTPR 471
Cdd:cd10564    79 SCLALQGVECRSCQDACPTQAIRfrpRLGGIALPELDADACTGCGACVSVCPVGAITLTPL 139
PRK10194 PRK10194
ferredoxin-type protein NapF;
420-506 4.03e-04

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 41.16  E-value: 4.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRALHTD-GASPSLKFVEQDCIQCGLCEKACPENVLTLTPRMNWvkeerQKAVVIHEE----KAAECI 494
Cdd:PRK10194   36 CTRCDACINACENNILQRGaGGYPSVNFKNNECSFCYACAQACPESLFSPRHTRAW-----DLQFTIGDAclayQSVECR 110

                          90
                  ....*....|..
gi 1140790947 495 RCHKPFAPQSMI 506
Cdd:PRK10194  111 RCQDSCEPMAII 122
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
156-236 4.80e-04

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 41.97  E-value: 4.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 156 IPTLMGTFDKPKFFRL--DTDLCAHssrgvkgCERCVDACPagalssegsdkTGHKI---EINPYLCQGVGTCATSCPTE 230
Cdd:COG0348   190 YGAFQGLLSDLSTLRVryDRGDCID-------CGLCVKVCP-----------MGIDIrkgEINQSECINCGRCIDACPKD 251


                  ....*.
gi 1140790947 231 AISYAL 236
Cdd:COG0348   252 AIRFSS 257
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 185-232 4.94e-04

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 41.17  E-value: 4.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 185 GCERCVDACPAGALSSEGSDKTGHKI-EINPYLCQGVGTCATSCPTEAI 232
Cdd:PRK12387   42 GCAACVNACPSNALTVETDLATGELAwEFNLGRCIFCGRCEEVCPTAAI 90
Fer4_9 pfam13187
4Fe-4S dicluster domain;
185-232 4.95e-04

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 38.30  E-value: 4.95e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 185 GCERCVDACPAGALsSEGSDKTGHKIEINPYLCQGVGTCATSCPTEAI 232
Cdd:pfam13187   4 GCGACVAACPAGAI-VPDLVGQTIRGDIAGLACIGCGACVDACPRGAI 50
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 416-481 5.31e-04

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 42.78  E-value: 5.31e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 416 ESKGCTLCMSCVAVCPT-----RALHT--DGASPSLKFVEQDCIQCGLCEKACPEN--VLTLTPRMNW--VKEERQK 481
Cdd:cd01916   363 LAAKCTDCGWCTRACPNslrikEAMEAakEGDFSGLADLFDQCVGCGRCEQECPKEipIINMIEKAARerIKEEKGK 439
DMSO_dmsB TIGR02951
DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain ...
 417-462 5.37e-04

DMSO reductase, iron-sulfur subunit; This family consists of the iron-sulfur subunit, or chain B, of an enzyme called the anaerobic dimethyl sulfoxide reductase. Chains A and B are catalytic, while chain C is a membrane anchor.


Pssm-ID: 131996 [Multi-domain]  Cd Length: 161  Bit Score: 40.87  E-value: 5.37e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 417 SKGCTLCMS--CVAVCPTRALHTdGASPSLKFVEQD-CIQCGLCEKACP 462
Cdd:TIGR02951  61 SISCNHCADpaCVKNCPTGAMYK-REEDGLVLVDQDkCIGCRYCVWACP 108
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
423-474 5.42e-04

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 42.35  E-value: 5.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 423 CM-----SCVAVCPTRALHTDGASPSLKFVEQDCIQCGLCEKACPENVltltPRMNW 474
Cdd:PRK10882  112 CMhcvdpNCVSVCPVSALTKDPKTGIVHYDKDVCTGCRYCMVACPFNV----PKYDY 164
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 426-470 5.89e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 40.34  E-value: 5.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1140790947 426 CVAVCPTRALHTDGASPSLkFVEQDCIQCGLCEKACPENVLTLTP 470
Cdd:cd16374    51 CMEVCPTGAIYRDEDGAVL-VDPDKCIGCGMCAMACPFGVPRFDP 94
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 152-234 6.51e-04

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 40.46  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 152 ALEEIPTLMGTFDkpkfFRLDTDLCAHssrgvkgCER--CVDACPAGALSsegSDKTGhKIEINPYLCQGVGTCATSCPT 229
Cdd:cd16366    50 RFYEVEKPGGDLS----WLFRKDQCMH-------CTDagCLAACPTGAII---RTETG-TVVVDPETCIGCGYCVNACPF 114


                  ....*
gi 1140790947 230 EAISY 234
Cdd:cd16366   115 DIPRF 119
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
185-233 6.59e-04

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 40.64  E-value: 6.59e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 185 GCERCVDACPAGALSSEGSDKTGHKIEINPY--------LCqgvGTCATSCPTEAIS 233
Cdd:PRK05888   62 ACKLCAAICPADAITIEAAEREDGRRRTTRYdinfgrciFC---GFCEEACPTDAIV 115
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 423-473 7.47e-04

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 40.36  E-value: 7.47e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 423 CM-----SCVAVCPTRALHTDgASPSLKFVEQDCIQCGLCEKACPENVLTLTPRMN 473
Cdd:cd10562    70 CMhctdaACVKVCPTGALYKT-ENGAVVVDEDKCIGCGYCVAACPFDVPRYDETTN 124
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 445-496 8.06e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.17  E-value: 8.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 445 KFVEQDCIQCGLCEKACPENVLTLtprmnwvkeERQKAVVIHEEKaaeCIRC 496
Cdd:COG1149     7 VIDEEKCIGCGLCVEVCPEGAIKL---------DDGGAPVVDPDL---CTGC 46
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 420-496 9.28e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 39.68  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGAS-PSLKFVEQD----------CIQCG--LCEKACPENVLTLTPRMnwvkeerqkAVVIH 486
Cdd:cd04410     8 CIGCGTCEVACKQEHGLRPGPDwSRIKVIEGGgleraflpvsCMHCEdpPCVKACPTGAIYKDEDG---------IVLID 78

                          90
                  ....*....|
gi 1140790947 487 EEKaaeCIRC 496
Cdd:cd04410    79 EDK---CIGC 85
FDH_beta_like cd16366
beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family ...
 423-475 9.60e-04

beta FeS subunits of formate dehydrogenase N (FDH-N) and similar proteins; This family contains beta FeS subunits of several dehydrogenases in the DMSO reductase superfamily, including formate dehydrogenase N (FDH-N), tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N is a major component of nitrate respiration of Escherichia coli; it catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate to a cytochrome. W-FDH contains a tungsten instead of molybdenum at the catalytic center and seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It catalyzes the oxidation of formate to carbon dioxide, donating the electrons to a second substrate.


Pssm-ID: 319888 [Multi-domain]  Cd Length: 156  Bit Score: 40.08  E-value: 9.60e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1140790947 423 CM-----SCVAVCPTRAL-HTDGAspSLKFVEQDCIQCGLCEKACPENVltltPRMNWV 475
Cdd:cd16366    70 CMhctdaGCLAACPTGAIiRTETG--TVVVDPETCIGCGYCVNACPFDI----PRFDEE 122
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 170-234 9.79e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 39.56  E-value: 9.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1140790947 170 RLDTDLCAhssrgvkGCERCVDACPAGALsseGSDKTGHKieinPYLCQGVGTCATSCPTEAISY 234
Cdd:cd16370    79 VLDKEKCI-------GCGNCVKACIVGAI---FWDEETNK----PIICIHCGYCARYCPHDVLAM 129
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 155-261 1.01e-03

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 40.83  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 155 EIPTLMGTFDKPKFFR--LDTDLCAHssrgvkgCER--CVDACPAGALSSEGSDKtghkIEINPYLCQGVGTCATSCPTE 230
Cdd:cd10560    55 ERPTEDGPANEGGDLQwlFMSDVCKH-------CTDagCLEACPTGAIFRTEFGT----VYIQPDICNGCGYCVAACPFG 123

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1140790947 231 AISYalpNPDDTQKFiERTLANYEQAGGLDP 261
Cdd:cd10560   124 VIDR---NEETGRAH-KCTLCYDRLKDGLEP 150
PRK13795 PRK13795
hypothetical protein; Provisional
 451-496 1.04e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 41.90  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1140790947 451 CIQCGLCEKACPENVLTLtprmnwvkEERQKAVVIHEEKaaeCIRC 496
Cdd:PRK13795  583 CVGCGVCVGACPTGAIRI--------EEGKRKISVDEEK---CIHC 617
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
171-234 1.19e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 39.26  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1140790947 171 LDTDLCAhssrgvkGCERCVDACPAGALSSEGSDKTGHKIEINpyLCQGVGT---CATSCPTEAISY 234
Cdd:COG1142    78 VDEEKCI-------GCGLCVLACPFGAITMVGEKSRAVAVKCD--LCGGREGgpaCVEACPTGALRL 135
PRK13795 PRK13795
hypothetical protein; Provisional
 185-228 1.28e-03

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 41.52  E-value: 1.28e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1140790947 185 GCERCVDACPAGALSSEGSDKtghKIEINPYLCQGVGTCATSCP 228
Cdd:PRK13795  585 GCGVCVGACPTGAIRIEEGKR---KISVDEEKCIHCGKCTEVCP 625
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
186-235 1.30e-03

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 39.26  E-value: 1.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140790947 186 CER--CVDACPAGALSsegsdKTGHKIEINPYLCQGVGTCATSCPTEAISYA 235
Cdd:COG1142    55 CEDapCAEVCPVGAIT-----RDDGAVVVDEEKCIGCGLCVLACPFGAITMV 101
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
426-496 1.31e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 40.82  E-value: 1.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1140790947 426 CVAVCPTRALHT---DGASPSLKFVEQDCIQCGLCEKACPENvltLTPRMNWVkeerqkavviheeKAAECIRC 496
Cdd:COG0348   184 CRYLCPYGAFQGllsDLSTLRVRYDRGDCIDCGLCVKVCPMG---IDIRKGEI-------------NQSECINC 241
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 420-497 1.58e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 39.16  E-value: 1.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRALH----TDGAS----PSLKFVEQDCIQCG-LCEKACPENVLTLTPrmnwvKEERQ----KAVVIH 486
Cdd:cd16373    16 CIRCGLCVEACPTGVIQpaglEDGLEggrtPYLDPREGPCDLCCdACVEVCPTGALRPLD-----LEEQKvkmgVAVIDK 90

                          90
                  ....*....|....*.
gi 1140790947 487 EE-----KAAECIRCH 497
Cdd:cd16373    91 DRclawqGGTDCGVCV 106
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
413-469 1.71e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 40.69  E-value: 1.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 413 VSCESK------------GCTLCMSCVAVCPTRALHTDGAspsLKFVEQD-CIQCGLCEKACPENVLTLT 469
Cdd:PRK07118  196 VACNSKdkgkavkkvcevGCIGCGKCVKACPAGAITMENN---LAVIDQEkCTSCGKCVEKCPTKAIRIL 262
PhsB_like cd10553
uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This ...
 426-472 2.16e-03

uncharacterized beta subfamily of DMSO Reductase similar to Desulfonauticus sp PhsB; This family includes beta FeS subunits of anaerobic DMSO reductase (DMSOR) superfamily that have yet to be characterized. DMSOR consists of a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and the tungsten-containing formate dehydrogenase (FDH-T). Examples of heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319875 [Multi-domain]  Cd Length: 146  Bit Score: 38.88  E-value: 2.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1140790947 426 CVAVCPTRALhTDGASPSLKFVEQD-CIQCGLCEKACPENVLTLTPRM 472
Cdd:cd10553    66 CVKACPTGAM-QKREKDGIVYVDQElCIGCKACIEACPWGIPQWNPAT 112
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 161-234 2.50e-03

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.16  E-value: 2.50e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1140790947 161 GTFDKPKFFRLdTDLCAHssrgvkgCER--CVDACPAGALSSegsDKTGHkIEINPYLCQGVGTCATSCPTEAISY 234
Cdd:COG0437    46 GEFPNVEWLFV-PVLCNH-------CDDppCVKVCPTGATYK---REDGI-VLVDYDKCIGCRYCVAACPYGAPRF 109
FrhG TIGR03294
coenzyme F420 hydrogenase, subunit gamma; This model represents that clade of F420-dependent ...
 194-232 2.50e-03

coenzyme F420 hydrogenase, subunit gamma; This model represents that clade of F420-dependent hydrogenases (FRH) beta subunits found exclusively and universally in methanogenic archaea. This protein contains two 4Fe-4S cluster binding domains (pfam00037) and scores above the trusted cutoff to model pfam01058 for the "NADH ubiquinone oxidoreductase, 20 Kd subunit" family.


Pssm-ID: 132337 [Multi-domain]  Cd Length: 228  Bit Score: 39.84  E-value: 2.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1140790947 194 PAGALSSEGSDKTGHKIE---INPYLCQGVGTCATSCPTEAI 232
Cdd:TIGR03294 150 PLAALAEEGTEACGCDLMtkvVNQGLCMGCGTCAAACPTRAI 191
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
420-496 3.11e-03

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 39.53  E-value: 3.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 420 CTLCMSCVAVCPTRAL---------------HTDGASPSlKFVEQDCIQCGLCEKACPENVLTLtprmnwvkeERQKAVV 484
Cdd:PRK07118  170 CTGCGACVKACPRNVIelipksarvfvacnsKDKGKAVK-KVCEVGCIGCGKCVKACPAGAITM---------ENNLAVI 239

                          90
                  ....*....|..
gi 1140790947 485 IHeEKAAECIRC 496
Cdd:PRK07118  240 DQ-EKCTSCGKC 250
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 420-465 3.15e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 36.13  E-value: 3.15e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 420 CTLCMSCVAVCPT---RALHTDGASPSLKFVEQ--------------DCIQCGLCEKACPENV 465
Cdd:pfam13183   2 CIRCGACLAACPVylvTGGRFPGDPRGGAAALLgrlealeglaeglwLCTLCGACTEVCPVGI 64
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 417-492 3.40e-03

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 39.48  E-value: 3.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 417 SKGCTLCMSCVAVCPTRALHTDGASPSLKFVEqDCIQCGLCEKACPENVLTLTPRMNW------------VKEERQKAVV 484
Cdd:PRK00783  168 SEDCDECEKCVEACPRGVLELKEGKLVVTDLL-NCSLCKLCERACPGKAIRVSDDENKfiftvesdgslpVEEILLEALK 246


                  ....*...
gi 1140790947 485 IHEEKAAE 492
Cdd:PRK00783  247 ILKRKADE 254
FDH-N cd10558
The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS ...
 423-473 3.44e-03

The beta FeS subunit of formate dehydrogenase-N (FDH-N); This subfamily contains beta FeS subunit of formate dehydrogenase-N (FDH-N), a member of the DMSO reductase family. FDH-N is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. Thus, FDH-N is a major component of nitrate respiration of Escherichia coli. This integral membrane enzyme forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups.


Pssm-ID: 319880 [Multi-domain]  Cd Length: 208  Bit Score: 38.91  E-value: 3.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1140790947 423 CM-----SCVAVCPTR-AL--HTDGAspsLKFVEQDCIQCGLCEKACPENVltltPRMN 473
Cdd:cd10558    70 CMhcadpGCLKACPSPgAIvqYANGI---VDFQSDKCIGCGYCIKGCPFDI----PRIS 121
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 426-468 3.96e-03

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 40.01  E-value: 3.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1140790947 426 CVAVCPTRALHTdgASPSLKFVEQDCIQCGLCEKACPENVLTL 468
Cdd:PRK12809   64 CVTACPVNALTF--QSDSVQLDEQKCIGCKRCAIACPFGVVEM 104
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 208-233 4.41e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.80  E-value: 4.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 1140790947 208 HKIEINPYLCQGVGTCATSCPTEAIS 233
Cdd:COG2221     8 WPPKIDEEKCIGCGLCVAVCPTGAIS 33
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 171-234 4.78e-03

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 38.91  E-value: 4.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 171 LDTDLCahssrgvKGCERCVDACPAGALssEGSDKTGHKIEINpyLC---QGVG---TCATSCPTEAISY 234
Cdd:cd10560   105 IQPDIC-------NGCGYCVAACPFGVI--DRNEETGRAHKCT--LCydrLKDGlepACAKACPTGSIQF 163
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 420-465 5.42e-03

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 38.57  E-value: 5.42e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGASPS--------------------LKFVEQD-----CIQCGLCEKACPENV 465
Cdd:COG0479   144 CILCGACVAACPNVWANPDFLGPAalaqayrfaldprdeeteerLEALEDEegvwrCTTCGNCTEVCPKGI 214
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
420-468 5.82e-03

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.46  E-value: 5.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1140790947 420 CTLCMSCVAVCPTRALHTDGASPSlKFVEQDCIQCGLCEKACPENVLTL 468
Cdd:COG1148   498 CTGCGRCVEVCPYGAISIDEKGVA-EVNPALCKGCGTCAAACPSGAISL 545
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 451-496 5.87e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 35.52  E-value: 5.87e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1140790947 451 CIQCGLCEKACPENVLTLTPRM-------NWVKEERQKavvihEEKAAECIRC 496
Cdd:pfam13534   2 CIQCGCCVDECPRYLLNGDEPKklmraayLGDLEELQA-----NKVANLCSEC 49
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 161-249 6.21e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 37.90  E-value: 6.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 161 GTFDKPKFFRLDTdLCAHssrgvkgCER--CVDACPAGAlssegSDKTGHKI-EINPYLCQGVGTCATSCPTEAISYalp 237
Cdd:cd10551    39 GEYPNVKRTFLPV-LCNH-------CENppCVKVCPTGA-----TYKREDGIvLVDYDKCIGCRYCMAACPYGARYF--- 102

                          90
                  ....*....|..
gi 1140790947 238 NPDDTQKFIERT 249
Cdd:cd10551   103 NPEEPHEFGEVP 114
PLN00071 PLN00071
photosystem I subunit VII; Provisional
 419-468 7.29e-03

photosystem I subunit VII; Provisional


Pssm-ID: 177700 [Multi-domain]  Cd Length: 81  Bit Score: 35.69  E-value: 7.29e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140790947 419 GCTLCMSCVAVCPTRALHT---DG-------ASPSLkfveQDCIQCGLCEKACPENVLTL 468
Cdd:PLN00071   10 TCIGCTQCVRACPTDVLEMipwDGckakqiaSAPRT----EDCVGCKRCESACPTDFLSV 65
DMSOR_beta_like cd16367
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 420-468 8.45e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319889 [Multi-domain]  Cd Length: 138  Bit Score: 36.90  E-value: 8.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1140790947 420 CTLCMS--CVAVCPTRALHTDGASPSlkFVEQDCIQCGLCEKACPENVLTL 468
Cdd:cd16367    57 CRHCVDpvCMIGCPTGAIHRDDGGEV--VISDACCGCGNCASACPYGAIQM 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH