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Conserved domains on  [gi|1140818639|ref|WP_076676236|]
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MULTISPECIES: prepilin-type N-terminal cleavage/methylation domain-containing protein [Vibrio]

Protein Classification

PilV family protein( domain architecture ID 11471938)

PilV family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
1-84 2.46e-07

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


:

Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 46.90  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   1 MDVKQKKRPQ-GFSLIEMVIVITLIGFALAGLtASLYPRSIQ-TAEQITSVKAADLGRSVLDEVMGRGYDhfSGVNGGVP 78
Cdd:COG4967     1 MSRRRRRRRQrGFTLIEVLVALVILSIGLLGL-AGLQAASLRsSQDARQRTQAALLAQDLLERLRANPAA--AGSYPGIK 77


                  ....*.
gi 1140818639  79 ECAVST 84
Cdd:COG4967    78 SITVTV 83
 
Name Accession Description Interval E-value
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
1-84 2.46e-07

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 46.90  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   1 MDVKQKKRPQ-GFSLIEMVIVITLIGFALAGLtASLYPRSIQ-TAEQITSVKAADLGRSVLDEVMGRGYDhfSGVNGGVP 78
Cdd:COG4967     1 MSRRRRRRRQrGFTLIEVLVALVILSIGLLGL-AGLQAASLRsSQDARQRTQAALLAQDLLERLRANPAA--AGSYPGIK 77


                  ....*.
gi 1140818639  79 ECAVST 84
Cdd:COG4967    78 SITVTV 83
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 6-32 2.56e-04

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 36.97  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*..
gi 1140818639   6 KKRPQGFSLIEMVIVITLIGFALAGLT 32
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PRK10506 PRK10506
prepilin peptidase-dependent protein;
7-127 3.81e-04

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 39.59  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   7 KRPQGFSLIEMVIVITLIG-FALAGLTASLYPRSIQTAEQiTSVKAADLGRSVLDEVMGRGYDH-FSGVNGGVPECAVSt 84
Cdd:PRK10506    6 KKQRGYTLIELLVVMTIVSiLSAWGLYGWQRWQQRQRLWQ-TAQQLLDFLLRLQEDANWHNRDHiLWLIREGQGWCLVS- 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1140818639  85 mSTPSQQLCTLPNDLGPENGETDVngVLVKSLANDVdDFHGLR 127
Cdd:PRK10506   84 -SVAGANTCTGSSPFVFTPPWPDV--ALASDTTPSL-AFYGLR 122
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 10-32 6.23e-03

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 33.05  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 1140818639  10 QGFSLIEMVIVITLIGFALAGLT 32
Cdd:TIGR02532   2 RGFTLIELLVVLAILGILALIAL 24
 
Name Accession Description Interval E-value
PilV COG4967
Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];
1-84 2.46e-07

Type IV pilus assembly protein PilV [Cell motility, Extracellular structures];


Pssm-ID: 443993 [Multi-domain]  Cd Length: 86  Bit Score: 46.90  E-value: 2.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   1 MDVKQKKRPQ-GFSLIEMVIVITLIGFALAGLtASLYPRSIQ-TAEQITSVKAADLGRSVLDEVMGRGYDhfSGVNGGVP 78
Cdd:COG4967     1 MSRRRRRRRQrGFTLIEVLVALVILSIGLLGL-AGLQAASLRsSQDARQRTQAALLAQDLLERLRANPAA--AGSYPGIK 77


                  ....*.
gi 1140818639  79 ECAVST 84
Cdd:COG4967    78 SITVTV 83
PulG COG2165
Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, ...
 4-61 1.04e-06

Type II secretory pathway, pseudopilin PulG [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 441768 [Multi-domain]  Cd Length: 99  Bit Score: 45.29  E-value: 1.04e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1140818639   4 KQKKRPQGFSLIEMVIVITLIGFaLAGLTASLYPRSIQTAEQITSVKAADLGRSVLDE 61
Cdd:COG2165     5 RRRRRQRGFTLIELLVVIAIIGI-LAALALPALQGARERARRAELRSNLRQIQQALER 61
PilE COG4968
Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];
1-52 2.37e-05

Type IV pilus assembly protein PilE [Cell motility, Extracellular structures];


Pssm-ID: 443994 [Multi-domain]  Cd Length: 124  Bit Score: 42.37  E-value: 2.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140818639   1 MDVKQKKRPQGFSLIEMVIVITLIGfALAGLTASLYPRSIQTAeQITSVKAA 52
Cdd:COG4968     1 MKKRMRRRQRGFTLIELMIVVAIIG-ILAAIAIPSYQDYVERA-RRAEAKAA 50
FimT COG4970
Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];
4-44 2.41e-04

Type IV pilus assembly protein FimT [Cell motility, Extracellular structures];


Pssm-ID: 443996 [Multi-domain]  Cd Length: 73  Bit Score: 38.29  E-value: 2.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1140818639   4 KQKKRPQGFSLIEMVIVITLIGfALAGLTASLYPRSIQTAE 44
Cdd:COG4970     3 RLRRRQRGFTLIELLVVLAILA-ILAAIAVPSFSSLIARQR 42
N_methyl pfam07963
Prokaryotic N-terminal methylation motif; This short motif directs methylation of the ...
 6-32 2.56e-04

Prokaryotic N-terminal methylation motif; This short motif directs methylation of the conserved phenylalanine residue. It is most often found at the N-terminus of pilins and other proteins involved in secretion, see pfam00114, pfam05946, pfam02501 and pfam07596.


Pssm-ID: 429756 [Multi-domain]  Cd Length: 27  Bit Score: 36.97  E-value: 2.56e-04
                          10        20
                  ....*....|....*....|....*..
gi 1140818639   6 KKRPQGFSLIEMVIVITLIGFALAGLT 32
Cdd:pfam07963   1 MRKQRGFTLIELLVALAILAILLAAAL 27
PRK10506 PRK10506
prepilin peptidase-dependent protein;
7-127 3.81e-04

prepilin peptidase-dependent protein;


Pssm-ID: 236704 [Multi-domain]  Cd Length: 162  Bit Score: 39.59  E-value: 3.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   7 KRPQGFSLIEMVIVITLIG-FALAGLTASLYPRSIQTAEQiTSVKAADLGRSVLDEVMGRGYDH-FSGVNGGVPECAVSt 84
Cdd:PRK10506    6 KKQRGYTLIELLVVMTIVSiLSAWGLYGWQRWQQRQRLWQ-TAQQLLDFLLRLQEDANWHNRDHiLWLIREGQGWCLVS- 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1140818639  85 mSTPSQQLCTLPNDLGPENGETDVngVLVKSLANDVdDFHGLR 127
Cdd:PRK10506   84 -SVAGANTCTGSSPFVFTPPWPDV--ALASDTTPSL-AFYGLR 122
PulJ COG4795
Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and ...
 4-47 4.41e-04

Type II secretory pathway, PulJ/GspJ component [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 443823 [Multi-domain]  Cd Length: 118  Bit Score: 38.46  E-value: 4.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1140818639   4 KQKKRPQGFSLIEMVIVITlIGFALAGLTASLYPRSIQTAEQIT 47
Cdd:COG4795     3 RARRRQRGFTLLELLVALA-IFALLLLAAYRGLDSVLRSRERLE 45
ComGC COG4537
Competence protein ComGC [Mobilome: prophages, transposons];
4-25 2.94e-03

Competence protein ComGC [Mobilome: prophages, transposons];


Pssm-ID: 443603 [Multi-domain]  Cd Length: 108  Bit Score: 36.06  E-value: 2.94e-03
                          10        20
                  ....*....|....*....|..
gi 1140818639   4 KQKKRPQGFSLIEMVIVITLIG 25
Cdd:COG4537     6 RKLKKEKGFTLIEMLIVLLIIS 27
IV_pilin_GFxxxE TIGR02532
prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all ...
 10-32 6.23e-03

prepilin-type N-terminal cleavage/methylation domain; This model describes many but not all examples of the N-terminal region of bacterial proteins that resemble type IV pilins at their N-terminus, with a cleavage site G^FxxxE followed by a hydrophobic stretch. The new N-terminal residue, usually Phe, is methylated. Separate domains of the prepilin peptidase appear responsible for cleavage and methylation. Proteins with this N-terminal region include type IV pilins and other components of pilus biogenesis, competence proteins, and type II secretion proteins. Typically several proteins in a single operon have this N-terminal domain. The N-terminal cleavage and methylation site is described by PROSITE motif PS00409 as [KRHEQSTAG]-G-[FYLIVM]-[ST]-[LT]-[LIVP]-E-[LIVMFWSTAG](14). [Cell envelope, Surface structures, Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 274182 [Multi-domain]  Cd Length: 24  Bit Score: 33.05  E-value: 6.23e-03
                          10        20
                  ....*....|....*....|...
gi 1140818639  10 QGFSLIEMVIVITLIGFALAGLT 32
Cdd:TIGR02532   2 RGFTLIELLVVLAILGILALIAL 24
PilA COG4969
Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];
6-89 8.27e-03

Type IV pilus assembly protein, major pilin PilA [Cell motility, Extracellular structures];


Pssm-ID: 443995 [Multi-domain]  Cd Length: 134  Bit Score: 35.07  E-value: 8.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   6 KKRPQGFSLIEMVIVITLIGfALAGLTASLYPRSIQTAeQITSVKAAdlGRSVLDEVmgrgyDHFSGVNGGVPECAVSTM 85
Cdd:COG4969     2 KKKQKGFTLIELMIVVAIIG-ILAAIAIPAYQDYVARA-RVSEALAL--ASPLKTAV-----EECALENGSLPNCNAGDN 72


                  ....
gi 1140818639  86 STPS 89
Cdd:COG4969    73 GLPA 76
PilW COG4966
Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];
6-158 9.42e-03

Type IV pilus assembly protein PilW [Cell motility, Extracellular structures];


Pssm-ID: 443992 [Multi-domain]  Cd Length: 158  Bit Score: 35.54  E-value: 9.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140818639   6 KKRPQGFSLIEMVIVITLIGFALAGLTaSLYPRSIQTAEQITSVKAADL-GRSVLDeVMGR-----GYDHfSGVNGGVPE 79
Cdd:COG4966     1 RRRQRGFTLVELMVALAIGLIVLAAVL-QLFLSSRRSYRTQEALARLQEnGRFALD-LLSRdlrqaGYFG-CASGNGNPN 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1140818639  80 CAVSTMSTPSQQLCTLPNDLGPENGETDVNGVLVKSLANDVDDFHGLRGRVEDVLDSDLSDAGYRNFNVEIDVFYDAAV 158
Cdd:COG4966    78 GGASVDIADDVSVLDVLLDTLGGSGDSTLGASSVTGLGDATDALSLDGVRLLVTLTTSATLNAGLVVSTVLALTLDTAV 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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