|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
177-1766 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1331.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 177 QESWRPALDAYAASLALAETGPVRETYETLRTEHGFRILDYKVDSDAAAPRACFTFSEAIRPKTDYAPFVAVSGSSAAAV 256
Cdd:COG2373 6 TLPLTPPLLLAALAALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 257 TGEGSQVcVDGLKHGGRYAIVVRQGLPSAVGESLLKAADYEIYVRDRAPQVRFTGRNYVLPRTGQAGVPLVSVNAPKLDV 336
Cdd:COG2373 86 SLLSAAA-LLLLALLAALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 337 EVLRIGDRGLL---PTLRSEDFLGQLSGSTARTIASEKGQRVWKGTLDTAKAEVNQEAVTAFPVLQAVGKLEPGLYVMLA 413
Cdd:COG2373 165 LLAAAAAALLAlaaLAAELAALLALALVLAAALLAPAALSEVALLLEPDLKGKLNKRVTTALPLSELLALLKPGVYLVVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 414 RPSGvaASDEEYDTQATQWFVVSDLGLTATKGRDGVHVVLRSLASAQVMPGAEIRLIARNNEVLGTRTTDAQGHVAFDPG 493
Cdd:COG2373 245 RFPG--DYSYNGESRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 494 LaRGEGGLAPSLVVAQAGGDYGFLDLNLG-AFDLTDRGVKGRPETGGLDAYLFPERGVYRTGETVQLTALLRDPRGAAVP 572
Cdd:COG2373 323 D-RGEGGRAPALLVARKGGDFAFLDLDDGpALDLSDFDVGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 573 DLPLTLVVKRPDGVEYRRVSVPDQGLGGRALPLPLLSGAMHGTWRVSAYTDPKaPAIGETSFLVEDYVPERLEVTLKARQ 652
Cdd:COG2373 402 GLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVDPK-PALGSKSFRVEEFKPPRFKVDLTLDK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 653 AALNRGEAAQVDVAARYLYGAPGADLDVSGSVTVQAAATSgIKGLETYSIGLDDEAVEPATQELQDhATTNAQGGATVTV 732
Cdd:COG2373 481 EPLKPGDPVTVTVDARYLFGAPAAGLKVEGEVTLRPARTA-FPGYPGYRFGDPDEEFEPEELDLGE-GTLDADGKASLSL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 733 PVPQV-AAPRALEAKITLAVGEPGGRALSRSLTLPILPASPVLALRK-GFTDLKEGGIAGFDAVFASPDGALLARPGVSW 810
Cdd:COG2373 559 PLPDApDAPGPLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLpLFDGDPEGAPATFEVVAVDPDGKPVAGKGLKV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 811 TLSRIDSSYQWY-RADGRWSFEAVKSARRVASGTVDLTAAGPSRIE-APVGLGRYRLEVSAAGApEATASLGFEVGWGGS 888
Cdd:COG2373 639 ELYREEWRYVWYkSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSlTPVEWGRYRLEVKDPDG-GLATSVRFYAGGNAS 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 889 ETAEAPDLLDLTLDKAAYAAGDTLRAKLSPKFRGQASLMVVSDRVHQTLEVSVPEGGTTVSIPVKAEWGAGAYLVATAYR 968
Cdd:COG2373 718 WGAERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVERDGVLETQWVDVKGGGTTVEIPVTEDWAPNAYVSATLVR 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 969 PLDQAAKRLPGRALGLAWFSVDRERRSLGVALKAPERARPRQDLTVPVQLTGLkAGEPARITVALVDVGILNLTRYAAPD 1048
Cdd:COG2373 798 PGDSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVKGA-AGKAAEVTLAAVDEGILNLTGYKTPD 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1049 PTQYFLGQRALGPEVRDLYGYLIDGMQGSAGAIRSGGDAGGGELADSPPTQ---APLALYSGVVTVGPDGAASVTFPIPA 1125
Cdd:COG2373 877 PLDFFYGKRALGVETRDLYGRLIGAFGGAAGALRSGGDGALGRGGNPKPPRkrfKPVALFSGPVKTDADGKATVSFDLPD 956
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1126 FNGTGRVMVTAWSGARVGQAQADVIIRDPVVLSATLPRFLDTGDRSRLFVALDNVEGRAGEYTVDLNPTGPVVVGASAlR 1205
Cdd:COG2373 957 FNGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEA-T 1035
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1206 QTLRLEAGAKGQFAIPLTAAGPGTARLDLALSGPGLPAAlnQSFALGISPGTGALLRRSVRSLAPGANLTLTSDLLADLQ 1285
Cdd:COG2373 1036 QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDA--REVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGGLR 1113
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1286 PGTGSVSLSATALPGVDVAALLRALDRYPYGCSEQVVSRAMPLLYVNKLAALEKLAL--DAGADERVRESIERLLARQDS 1363
Cdd:COG2373 1114 PGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGdkDAELRARIQAAIARLLSMQNS 1193
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1364 SGDFGLWSAQGSSDLWLDAYVTDFLTRARERGFAVPQKAFAQALDYLRNAVANATEV----RNGGADLAYAAYVLARNGR 1439
Cdd:COG2373 1194 DGGFGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYLRNPWEIeyddAYRLAVRAYALYVLARAGK 1273
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1440 PVMGDLRYLADTKiGDFSSALGRAQLAAALALLGDRGRAAKAMDSALTVLRTDRDKGQYRADYGSRLRDGAGLITLAAES 1519
Cdd:COG2373 1274 ADLGDLRYLYDRR-KDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYGDYGSPLRDQALALALLAEL 1352
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1520 GLAQGALGPAAAALGEEQQADRATSTQENAWMVLAAESLSNEAGG-----LSFTLDGAPQT----GTLARV-YREAALGE 1589
Cdd:COG2373 1353 GPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGAspdftATLTLDGKTLPltgrGPLARVtLPAAELLA 1432
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1590 RGVQLTNTGRNPVQVAVTVNGSPLV-PEPAAQQGYTIQRSFRRLDGSTVDPASgLRQNDRLVVVLKVTEAKAEAARLLLV 1668
Cdd:COG2373 1433 GPLTITNTGDGPLYYTLTLSGYPAEgPPPAASNGLEIERRYYDLDGKPIDPAS-LKQGDLVVVRLTVTAPSGRVENVAVV 1511
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1669 DPLPAGLEIDNPKLLDADALQglAFAKSDVQPVHTEFRDDRFVAAYDRDPSQSafFTVAYTVRAVSPGTYVHPGATVEDM 1748
Cdd:COG2373 1512 DPLPAGFEIENPRLATSGDLG--DWLGDSWQPDHQEFRDDRVVAAFDLDPAGT--YTFAYLVRAVTPGTFVLPPAQAEDM 1587
|
1610
....*....|....*...
gi 1140876017 1749 YRPARFGRTASGSVTVGA 1766
Cdd:COG2373 1588 YRPEVRARSAGGRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1303-1555 |
2.66e-37 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 142.53 E-value: 2.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1303 VAALLRALDRYPYGCSEQVVSRAMPLLYVNKLAA---LEKLALDAGADERVRESIERLLARQDSSGDFGLWSAQGSSDLW 1379
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1380 LDAYVTDFLTRA------------RERGFAVPQKAFAQALDYLRNAVANATE--VRNGGADLAYAAYVLARNG---RPVM 1442
Cdd:cd02891 81 LTAYVVKFLSQArkyidvdenvlaRALGWLVPQQKEDGSFRELGPVIHREMKggVDDSVSLTAYVLIALAEAGkacDASI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1443 GDLRYLADTKIGDFSSALGRAQLAAALALLGDRGRAAKAMDSALTVLR----TDRDKGQYRADYGSRLRDGAGLITLAAE 1518
Cdd:cd02891 161 EKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAARekggTAHWSLSWPGDYGSSLRVEATAYALLAL 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 1140876017 1519 SGLAQGALGPAAAALGEEQQA--DRATSTQENAWMVLAA 1555
Cdd:cd02891 241 LKLGDLEEAGPIAKWLAQQRNsgGGFLSTQDTVVALQAL 279
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
642-769 |
3.73e-37 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 136.49 E-value: 3.73e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 642 ERLEVTLKARQAALNRGEAAQVDVAARYLYGAPGADLDVSGSVTVQAAATSgIKGLETYSIGLDDEAVEPATQELQDhAT 721
Cdd:pfam17972 1 ERMDLDLSLPDAPLAPGDPAELDVDARYLYGAPAAGLRLEGELTLRPARHA-LAGFPGYRFGRHDEELLKRTRDLPD-LT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1140876017 722 TNAQGGATVTVPVPQVAAP-RALEAKITLAVGEPGGRALSRSLTLPILP 769
Cdd:pfam17972 79 TDAQGKATLTVPLPEWPAAtRPLEARVTVSLLESGGRPVERSLTRPVWP 127
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
177-1766 |
0e+00 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 1331.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 177 QESWRPALDAYAASLALAETGPVRETYETLRTEHGFRILDYKVDSDAAAPRACFTFSEAIRPKTDYAPFVAVSGSSAAAV 256
Cdd:COG2373 6 TLPLTPPLLLAALAALALLALLALLLGAALPLSPPPALALAIAALVLPAAPLLALLLAPLLLALAAAASALALAATLLAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 257 TGEGSQVcVDGLKHGGRYAIVVRQGLPSAVGESLLKAADYEIYVRDRAPQVRFTGRNYVLPRTGQAGVPLVSVNAPKLDV 336
Cdd:COG2373 86 SLLSAAA-LLLLALLAALALAVRAAALAASSALAAAAAALALAAALLAAALLALLAALAAAAALALALALAAAAAAALAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 337 EVLRIGDRGLL---PTLRSEDFLGQLSGSTARTIASEKGQRVWKGTLDTAKAEVNQEAVTAFPVLQAVGKLEPGLYVMLA 413
Cdd:COG2373 165 LLAAAAAALLAlaaLAAELAALLALALVLAAALLAPAALSEVALLLEPDLKGKLNKRVTTALPLSELLALLKPGVYLVVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 414 RPSGvaASDEEYDTQATQWFVVSDLGLTATKGRDGVHVVLRSLASAQVMPGAEIRLIARNNEVLGTRTTDAQGHVAFDPG 493
Cdd:COG2373 245 RFPG--DYSYNGESRATQWFLVSDLGLTAKRGDDGLLVFVTSLSTGKPVAGAEVELYDRNGQVLATATTDADGLARFPAG 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 494 LaRGEGGLAPSLVVAQAGGDYGFLDLNLG-AFDLTDRGVKGRPETGGLDAYLFPERGVYRTGETVQLTALLRDPRGAAVP 572
Cdd:COG2373 323 D-RGEGGRAPALLVARKGGDFAFLDLDDGpALDLSDFDVGGRAPPGGLDAFLFTDRGIYRPGETVHLKALLRDADGKAPA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 573 DLPLTLVVKRPDGVEYRRVSVPDQGLGGRALPLPLLSGAMHGTWRVSAYTDPKaPAIGETSFLVEDYVPERLEVTLKARQ 652
Cdd:COG2373 402 GLPLTLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLELYVDPK-PALGSKSFRVEEFKPPRFKVDLTLDK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 653 AALNRGEAAQVDVAARYLYGAPGADLDVSGSVTVQAAATSgIKGLETYSIGLDDEAVEPATQELQDhATTNAQGGATVTV 732
Cdd:COG2373 481 EPLKPGDPVTVTVDARYLFGAPAAGLKVEGEVTLRPARTA-FPGYPGYRFGDPDEEFEPEELDLGE-GTLDADGKASLSL 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 733 PVPQV-AAPRALEAKITLAVGEPGGRALSRSLTLPILPASPVLALRK-GFTDLKEGGIAGFDAVFASPDGALLARPGVSW 810
Cdd:COG2373 559 PLPDApDAPGPLRATVEASVFESGGRPVTRSATVPVHPADFYVGIRLpLFDGDPEGAPATFEVVAVDPDGKPVAGKGLKV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 811 TLSRIDSSYQWY-RADGRWSFEAVKSARRVASGTVDLTAAGPSRIE-APVGLGRYRLEVSAAGApEATASLGFEVGWGGS 888
Cdd:COG2373 639 ELYREEWRYVWYkSDDGGWRYESQEKEEPVAEGTLTTGADGPASLSlTPVEWGRYRLEVKDPDG-GLATSVRFYAGGNAS 717
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 889 ETAEAPDLLDLTLDKAAYAAGDTLRAKLSPKFRGQASLMVVSDRVHQTLEVSVPEGGTTVSIPVKAEWGAGAYLVATAYR 968
Cdd:COG2373 718 WGAERPDRLELSLDKESYKPGETAKLLIQSPFAGRALVTVERDGVLETQWVDVKGGGTTVEIPVTEDWAPNAYVSATLVR 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 969 PLDQAAKRLPGRALGLAWFSVDRERRSLGVALKAPERARPRQDLTVPVQLTGLkAGEPARITVALVDVGILNLTRYAAPD 1048
Cdd:COG2373 798 PGDSTANDMPARAYGVAPLPVDPPARRLKVELTAPEKLRPGETLTVTVKVKGA-AGKAAEVTLAAVDEGILNLTGYKTPD 876
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1049 PTQYFLGQRALGPEVRDLYGYLIDGMQGSAGAIRSGGDAGGGELADSPPTQ---APLALYSGVVTVGPDGAASVTFPIPA 1125
Cdd:COG2373 877 PLDFFYGKRALGVETRDLYGRLIGAFGGAAGALRSGGDGALGRGGNPKPPRkrfKPVALFSGPVKTDADGKATVSFDLPD 956
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1126 FNGTGRVMVTAWSGARVGQAQADVIIRDPVVLSATLPRFLDTGDRSRLFVALDNVEGRAGEYTVDLNPTGPVVVGASAlR 1205
Cdd:COG2373 957 FNGTLRVMAVAWSDDRFGSAEATVTVRKPLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGLTLEGEA-T 1035
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1206 QTLRLEAGAKGQFAIPLTAAGPGTARLDLALSGPGLPAAlnQSFALGISPGTGALLRRSVRSLAPGANLTLTSDLLADLQ 1285
Cdd:COG2373 1036 QTVTLAAGGRATVRFPLKAPDAGDAKVTVTATGGGESDA--REVELPVRPANPLVTRATSGVLAPGESWTLPLDLPGGLR 1113
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1286 PGTGSVSLSATALPGVDVAALLRALDRYPYGCSEQVVSRAMPLLYVNKLAALEKLAL--DAGADERVRESIERLLARQDS 1363
Cdd:COG2373 1114 PGTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSDLAEALGLKGdkDAELRARIQAAIARLLSMQNS 1193
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1364 SGDFGLWSAQGSSDLWLDAYVTDFLTRARERGFAVPQKAFAQALDYLRNAVANATEV----RNGGADLAYAAYVLARNGR 1439
Cdd:COG2373 1194 DGGFGLWPGGSESDPWLTAYATDFLLEAREAGYAVPDDALDRALDYLRNYLRNPWEIeyddAYRLAVRAYALYVLARAGK 1273
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1440 PVMGDLRYLADTKiGDFSSALGRAQLAAALALLGDRGRAAKAMDSALTVLRTDRDKGQYRADYGSRLRDGAGLITLAAES 1519
Cdd:COG2373 1274 ADLGDLRYLYDRR-KDALSPLAKAQLAAALALLGDKARAEELLAAALARLRETGARDYWYGDYGSPLRDQALALALLAEL 1352
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1520 GLAQGALGPAAAALGEEQQADRATSTQENAWMVLAAESLSNEAGG-----LSFTLDGAPQT----GTLARV-YREAALGE 1589
Cdd:COG2373 1353 GPDAPLAPKLARWLAKALKSGRWLSTQETAWALLALAAYARAAGAspdftATLTLDGKTLPltgrGPLARVtLPAAELLA 1432
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1590 RGVQLTNTGRNPVQVAVTVNGSPLV-PEPAAQQGYTIQRSFRRLDGSTVDPASgLRQNDRLVVVLKVTEAKAEAARLLLV 1668
Cdd:COG2373 1433 GPLTITNTGDGPLYYTLTLSGYPAEgPPPAASNGLEIERRYYDLDGKPIDPAS-LKQGDLVVVRLTVTAPSGRVENVAVV 1511
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1669 DPLPAGLEIDNPKLLDADALQglAFAKSDVQPVHTEFRDDRFVAAYDRDPSQSafFTVAYTVRAVSPGTYVHPGATVEDM 1748
Cdd:COG2373 1512 DPLPAGFEIENPRLATSGDLG--DWLGDSWQPDHQEFRDDRVVAAFDLDPAGT--YTFAYLVRAVTPGTFVLPPAQAEDM 1587
|
1610
....*....|....*...
gi 1140876017 1749 YRPARFGRTASGSVTVGA 1766
Cdd:COG2373 1588 YRPEVRARSAGGRVTVVA 1605
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1303-1555 |
2.66e-37 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 142.53 E-value: 2.66e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1303 VAALLRALDRYPYGCSEQVVSRAMPLLYVNKLAA---LEKLALDAGADERVRESIERLLARQDSSGDFGLWSAQGSSDLW 1379
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDatgQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNSDSGSTW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1380 LDAYVTDFLTRA------------RERGFAVPQKAFAQALDYLRNAVANATE--VRNGGADLAYAAYVLARNG---RPVM 1442
Cdd:cd02891 81 LTAYVVKFLSQArkyidvdenvlaRALGWLVPQQKEDGSFRELGPVIHREMKggVDDSVSLTAYVLIALAEAGkacDASI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1443 GDLRYLADTKIGDFSSALGRAQLAAALALLGDRGRAAKAMDSALTVLR----TDRDKGQYRADYGSRLRDGAGLITLAAE 1518
Cdd:cd02891 161 EKALAYLETQLDGLLDPYALAILAYALALAGDSTRADEALKKLLEAARekggTAHWSLSWPGDYGSSLRVEATAYALLAL 240
|
250 260 270
....*....|....*....|....*....|....*....
gi 1140876017 1519 SGLAQGALGPAAAALGEEQQA--DRATSTQENAWMVLAA 1555
Cdd:cd02891 241 LKLGDLEEAGPIAKWLAQQRNsgGGFLSTQDTVVALQAL 279
|
|
| bMG5 |
pfam17972 |
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
642-769 |
3.73e-37 |
|
Bacterial Alpha-2-macroglobulin MG5 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the N-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG5 domain.
Pssm-ID: 436183 Cd Length: 127 Bit Score: 136.49 E-value: 3.73e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 642 ERLEVTLKARQAALNRGEAAQVDVAARYLYGAPGADLDVSGSVTVQAAATSgIKGLETYSIGLDDEAVEPATQELQDhAT 721
Cdd:pfam17972 1 ERMDLDLSLPDAPLAPGDPAELDVDARYLYGAPAAGLRLEGELTLRPARHA-LAGFPGYRFGRHDEELLKRTRDLPD-LT 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1140876017 722 TNAQGGATVTVPVPQVAAP-RALEAKITLAVGEPGGRALSRSLTLPILP 769
Cdd:pfam17972 79 TDAQGKATLTVPLPEWPAAtRPLEARVTVSLLESGGRPVERSLTRPVWP 127
|
|
| bMG6 |
pfam17962 |
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 ... |
776-885 |
5.74e-35 |
|
Bacterial macroglobulin domain 6; This macroglobulin domain is found in bacterial alpha 2 macroglobulin proteins. It adopts an Ig-like beta sandwich fold.
Pssm-ID: 436175 Cd Length: 112 Bit Score: 129.68 E-value: 5.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 776 LRKGFTD--LKEGGIAGFDAVFASPDGALLARPGVSWTLSRIDSSYQWYRADGRWSFEAVKSARRVASGTVDLTAAGPSR 853
Cdd:pfam17962 2 IRPLFDDgsLEEGKEAAFEVVAVDADGKPVAVQGLEWTLYREEWDYQWYRQDGGWSYEPVTRDKRVATGTVDTGADGPAT 81
|
90 100 110
....*....|....*....|....*....|..
gi 1140876017 854 IEAPVGLGRYRLEVSAAGAPeATASLGFEVGW 885
Cdd:pfam17962 82 ISLPVDWGRYRLEVEDPGGG-AATSVRFYAGW 112
|
|
| bMG10 |
pfam17973 |
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1622-1751 |
2.77e-31 |
|
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9.
Pssm-ID: 465598 Cd Length: 128 Bit Score: 119.71 E-value: 2.77e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1622 GYTIQRSFRRLDGSTVDPASG--LRQNDRLVVVLKVTeAKAEAARLLLVDPLPAGLEIDNPklLDADALQGLAFAKSDVQ 1699
Cdd:pfam17973 1 GLSVTRRFYVLEGSGVSASDAetLKVGDKVRVRLTVT-TDRDRDFVALEDPLPAGLEPVNP--LSGYTWEGGLGYPDNTQ 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1140876017 1700 PVHTEFRDDRFVAAYDRDPSQSafFTVAYTVRAVSPGTYVHPGATVEDMYRP 1751
Cdd:pfam17973 78 PSYREVRDDRVRFFADYLPKGT--YTFEYLVRAVTPGTFTVPPATAESMYAP 127
|
|
| bMG3 |
pfam11974 |
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
435-536 |
8.43e-30 |
|
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins.
Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 114.62 E-value: 8.43e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 435 VSDLGLTATKGRDGVHVVLRSLASAQVMPGAEIRLIARNNEVLGTRTTDAQGHVAFDPGLARgEGGLAPSLVVAQAGGDY 514
Cdd:pfam11974 1 VSDLGLHAKQGRDGLLVWVTSLDSGKPVAGVEVRLLDCNGQVLATGTTDAQGHARFEGPLTR-DGGAAPALVSARKDGDF 79
|
90 100
....*....|....*....|...
gi 1140876017 515 GFLDLNLG-AFDLTDRGVKGRPE 536
Cdd:pfam11974 80 AFLRLDWGpALDLSDFDVGGRPP 102
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
541-636 |
3.91e-24 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 98.16 E-value: 3.91e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 541 DAYLFPERGVYRTGETVQLTALLRDPRGAAVPDLPLTLVVKRPDGVEYRRVSVPDQGLGGRALPLPLLSGAMHGTWRVSA 620
Cdd:pfam01835 1 RAFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVL 80
|
90
....*....|....*.
gi 1140876017 621 YtDPKAPAIGETSFLV 636
Cdd:pfam01835 81 R-DGAGGSLGSGSFRV 95
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
897-1041 |
1.91e-19 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 86.25 E-value: 1.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 897 LDLTLDKAAYAAGDTLRAKLSPKFRGQASLMVVSDRVHQTLEVSVPEGG---TTVSIPVKAEWGAGAYLVATAYRPldqa 973
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERDGFTYLVLSKGQIVVVGRGgvtTSFSLPVTAEMAPSARVVAYYVRV---- 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1140876017 974 AKRLPGRALGLAWFSVD-RERRSLGVALKaPERARPRQDLTVPVqltglKAGEPARITVALVDVGILNL 1041
Cdd:pfam07703 77 DLSKPEVVADSVWVDVDdTCENKLKVTLS-AEKYRPGSTVELKV-----KADPGAYVALAAVDKGVLLL 139
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
1303-1440 |
1.19e-17 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 85.68 E-value: 1.19e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1303 VAALLRALDRYPYG--------CSEQVVSRAMPLLYVNKLaaLEKLALDAGADERVRESIERLLARQDSSGDFGLWSAQG 1374
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLL--LAATGIRDKADENIEKGIQRLLSYQLSDGGFSGWGGND 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1140876017 1375 SSDLWLDAYVTDFLTRARERGFaVPQKAFAQALDYLRN------------AVANATEVRNGGADL-AYAAYVLARNGRP 1440
Cdd:cd00688 79 YPSLWLTAYALKALLLAGDYIA-VDRIDLARALNWLLSlqnedggfredgPGNHRIGGDESDVRLtAYALIALALLGKL 156
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
1307-1410 |
3.41e-03 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 41.52 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1307 LRALDRYPYGCSEQVVSRAMPLLYVNK-LAALEKLALDA--GADERVRESIERLLARQDSSGDFGLWSaQGSSDLWLDAY 1383
Cdd:pfam07678 19 LSSLLRLPYGCGEQNMVLFAPNVYVLRyLDKTNQLTKLIksKAIDYLEQGYQRQLSYKHPDGSYSAFG-HSPGSTWLTAF 97
|
90 100
....*....|....*....|....*..
gi 1140876017 1384 VTDFLTRARERGFaVPQKAFAQALDYL 1410
Cdd:pfam07678 98 VLKVFAQARKFIF-IDPEEICQSLRWL 123
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
1307-1410 |
5.75e-03 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 40.72 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140876017 1307 LRALDRYPYGCSEQVVSRAMPLLYVNK-LAALEKL-ALDAGADERVRESIE----RLLARQDSSGDFGLWSAQGSSdLWL 1380
Cdd:cd02896 5 LEKLIRLPTGCGEQTMIKLAPTVYALRyLDTTNQWeKLGPERRDEALKYIRqgyqRQLSYRKPDGSYAAWKNRPSS-TWL 83
|
90 100 110
....*....|....*....|....*....|
gi 1140876017 1381 DAYVTDFLTRARERGFaVPQKAFAQALDYL 1410
Cdd:cd02896 84 TAFVVKVFSLARKYIP-VDQNVICGSVNWL 112
|
|
| |
