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Conserved domains on  [gi|1150786867|ref|WP_077981009|]
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magnesium and cobalt transport protein CorA [Rhizobium laguerreae]

Protein Classification

magnesium and cobalt transport protein CorA( domain architecture ID 10191301)

magnesium and cobalt transport protein CorA mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 32-321 4.81e-137

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 389.96  E-value: 4.81e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  32 FIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEG--DQITYGETAIFVGKRYIITV 109
Cdd:cd12830     2 FVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARYVDhtEEVETGETHVFVGPDFVVTV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 110 RNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFLdRSQITRIFKLRREVI 189
Cdd:cd12830    82 RHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR-RDDIERIYRLKREVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 190 LFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAAWAA 269
Cdd:cd12830   161 EFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKISAWAA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1150786867 270 ILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12830   241 ILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
 
Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 32-321 4.81e-137

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 389.96  E-value: 4.81e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  32 FIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEG--DQITYGETAIFVGKRYIITV 109
Cdd:cd12830     2 FVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARYVDhtEEVETGETHVFVGPDFVVTV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 110 RNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFLdRSQITRIFKLRREVI 189
Cdd:cd12830    82 RHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR-RDDIERIYRLKREVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 190 LFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAAWAA 269
Cdd:cd12830   161 EFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKISAWAA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1150786867 270 ILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12830   241 ILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-321 1.92e-97

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 289.81  E-value: 1.92e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQL--EGDQITYGETAIFVGKRYI 106
Cdd:COG0598    12 PEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYneEEEELETGPLSIFLGPNFL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:COG0598    92 ITVRERPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESP-DNELLRRLYRLRR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAA 266
Cdd:COG0598   171 ELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKVLTI 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1150786867 267 WAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:COG0598   251 IAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 29-317 1.52e-55

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 182.13  E-value: 1.52e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEGDQITYGET--AIFVGKRYI 106
Cdd:pfam01544   1 EQGFVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADELVtvSILLGDNFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLcHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:pfam01544  81 ITVRHEPLPALDEVRKRLTLLGGGP-LDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDET-NNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHL-DLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLA 265
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRReDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1150786867 266 AWAAILAVPTAIAGIYGMNFDNMPELKTSYGYF--IVLAVIAIMCIALFIRFKR 317
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPfvLILGLMILLAILLLFYFRR 292
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 29-321 5.45e-52

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 173.73  E-value: 5.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELL-LLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAK-TAQLEGDQITYGETAIFVGKRYI 106
Cdd:TIGR00383  24 LNTVLWIDLIEPTDEERLaKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFfLNEDEDDTFETEQVSFILGKNLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:TIGR00383 104 FTIHERELPAFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP-TSTLMDEILSLRT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHLD-LPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLA 265
Cdd:TIGR00383 183 ELLALRRSLWPLRDVLNFLLRKThLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILT 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1150786867 266 AWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:TIGR00383 263 VVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
244-321 7.50e-09

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 55.88  E-value: 7.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 244 SVFEASNLLEQQRQGTITRQLAAWAAILAV-------PTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFK 316
Cdd:PRK11085  232 SLFQKVNFLMQAAMGFINIEQNRIIKIFSVvsvvflpPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFK 311


                  ....*
gi 1150786867 317 RARWI 321
Cdd:PRK11085  312 RKNWL 316
 
Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 32-321 4.81e-137

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 389.96  E-value: 4.81e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  32 FIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEG--DQITYGETAIFVGKRYIITV 109
Cdd:cd12830     2 FVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARYVDhtEEVETGETHVFVGPDFVVTV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 110 RNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFLdRSQITRIFKLRREVI 189
Cdd:cd12830    82 RHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR-RDDIERIYRLKREVL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 190 LFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAAWAA 269
Cdd:cd12830   161 EFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKISAWAA 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1150786867 270 ILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12830   241 ILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
29-321 1.92e-97

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 289.81  E-value: 1.92e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQL--EGDQITYGETAIFVGKRYI 106
Cdd:COG0598    12 PEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYneEEEELETGPLSIFLGPNFL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:COG0598    92 ITVRERPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESP-DNELLRRLYRLRR 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAA 266
Cdd:COG0598   171 ELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEIMKVLTI 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1150786867 267 WAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:COG0598   251 IAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 34-321 2.26e-87

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 263.66  E-value: 2.26e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQL--EGDQITYGETAIFVGKRYIITVRN 111
Cdd:cd12822     1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERQRPKIEEYDDYLFLVLRALRYdeEELELETSELSIFLGKNFLVTVHE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 112 GSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRREVILF 191
Cdd:cd12822    81 GPLRLIDEVIERLLSDPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEEP-RREVLRELFALRRELLRL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 192 QRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAAWAAIL 271
Cdd:cd12822   160 RRILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIITTIF 239

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1150786867 272 AVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12822   240 LPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 33-321 3.23e-61

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 196.88  E-value: 3.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  33 IWI---GLHKPsrDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEGD--QITYGETAIFVGKRYII 107
Cdd:cd12828     3 TWInvdGLHDI--ELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLYYDEDtgELESEQVSLILGKNYVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 108 TVRNGSERGHGELRGRLEAS-PKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAfLDRSQITRIFKLRR 186
Cdd:cd12828    81 SFQERPGDVFDPVRERLRNGkGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLEN-PTPETLERIHKLKR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEA--SNLleQQRQGTITRQL 264
Cdd:cd12828   160 ELLFLRRSIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLylSSV--SNRMNEVMKVL 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1150786867 265 AAWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12828   238 TIISTIFIPLTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 29-317 1.52e-55

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 182.13  E-value: 1.52e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTAQLEGDQITYGET--AIFVGKRYI 106
Cdd:pfam01544   1 EQGFVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADELVtvSILLGDNFL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLcHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:pfam01544  81 ITVRHEPLPALDEVRKRLTLLGGGP-LDPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDET-NNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHL-DLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLA 265
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRReDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1150786867 266 AWAAILAVPTAIAGIYGMNFDNMPELKTSYGYF--IVLAVIAIMCIALFIRFKR 317
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPfvLILGLMILLAILLLFYFRR 292
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 31-320 4.40e-54

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 178.12  E-value: 4.40e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  31 EFIWIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAKTaqLEGDQITYGETAIFVGKRYIITVR 110
Cdd:cd12831     1 KWYWVDFNNPTEEEIKLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLHA--IDQEDLEAEEVNLFVGENYIVTFH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 111 NGSERGHGELRGRLEaSPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDaflDRSQ--ITRIFKLRREV 188
Cdd:cd12831    79 KEPIREINEVWEKLK-EKKDKKLGTLYIAYMIIDKIVDDYFPIVYEIEDRLNEIEDNNVD---SSNKklMDEVFDIRSDL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 189 ILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDvITSVFEASNL-LEQQRQGTITRQLAAW 267
Cdd:cd12831   155 LKLRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNRE-MTADIRDNYEsYNSNRMNSIMMTLTII 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1150786867 268 AAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARW 320
Cdd:cd12831   234 STIFMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLLIAIGMILWFKKKGW 286
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 29-321 5.45e-52

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 173.73  E-value: 5.45e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  29 DNEFIWIGLHKPSRDELL-LLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAK-TAQLEGDQITYGETAIFVGKRYI 106
Cdd:TIGR00383  24 LNTVLWIDLIEPTDEERLaKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFfLNEDEDDTFETEQVSFILGKNLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 107 ITVRNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFlDRSQITRIFKLRR 186
Cdd:TIGR00383 104 FTIHERELPAFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP-TSTLMDEILSLRT 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKLYHLD-LPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLA 265
Cdd:TIGR00383 183 ELLALRRSLWPLRDVLNFLLRKThLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILT 262

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1150786867 266 AWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:TIGR00383 263 VVSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 34-321 1.20e-35

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 130.03  E-value: 1.20e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVI-----------AKTAQLEGDQItygetAIFVG 102
Cdd:cd12832     1 WIDVVAPTEEDLEDLARRYNLHETSLKDCLDPDHLPKYEEVDGVTFIIlrvytdkkrenADTIQELTTKI-----AIFVV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 103 KRYIITVRNGSERGHGELRGRLEaSPKTLCHGTDYILHAILDFIIDGY-LPIVRTIEDavLD-MERKMldaFLDRSQIT- 179
Cdd:cd12832    76 DKFVITIHRTDLEFIANLKEKWL-SGMHKCESPTELLLRIVKDALKTYeAPLEKLSEE--LDkYEEEV---FLKKRKGSl 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 180 --RIFKLRREVILFQRVLDAMLDLCGKLYHLDLPsldreaKPYFRDALQHMHRVETMVASLRDvitsvfEASNLLEQ--- 254
Cdd:cd12832   150 lkRLYHLKRKASVIKRVLNLTQDVIDKIDTPLKS------DPYTQDLRDLLIKLLSLYDELHE------NATNLLSLyis 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1150786867 255 ---QRQGTITRQLAawaaILAV---P-TAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12832   218 lssQRTNEVMRVLT----IFSVfflPlTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVIVVGIYFWFKRKGWL 287
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 34-320 1.10e-27

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 108.94  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHE----LSIADALSSLQMPKlsVYDNQLFVIAKTAQLEGDQITYGetaIFVGKRYIITV 109
Cdd:cd12821     1 WYDIDEPDDEIRRLLEELESSHLpndlRDILLGVSFPRFEE--VSGSGIYIQLRKPQKDADTASFH---FLITRDRLITV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 110 RNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAfLDRSQITRIFKLRREVI 189
Cdd:cd12821    76 RLDELPALDELRQDLRSGQMKSAKSAAELLFVLLGAIIKALLTGIDQFEEKLEELEWDLLEG-NNAIKLDRILELRRELL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 190 LFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLAAWAA 269
Cdd:cd12821   155 RLTNLIEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEIMKTLTVVTT 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1150786867 270 ILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARW 320
Cdd:cd12821   235 VFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 34-321 8.26e-27

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 106.63  E-value: 8.26e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHeLSIADALSSLQM-PKLSVYDNQLFVIAKTAQLEGDQITYGETAIFV-GKRYIITVRN 111
Cdd:cd12825     1 WIDLINPTEEELATLSSEYGFI-LPPREHLEDIEIsSRYWEDDSQLFITLSFPNQTKEDTIEEEPVTFIiKGNILFTIRY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 112 GSERGHGELRGRLEASPKTLCHGTDyILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFLDRSQ----ITRI----FK 183
Cdd:cd12825    80 RDLPAFDIFPKRAFSQRKFFNSGEE-LFLFLFEVIVDYLADILENISKKIKQLSREILEEKQFSEEdldaLTKLnennIT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 184 LRREVILFQRVLdamldlcgkLYHLDLPSLDREAKPYFRDALqhmhrveTMVASLRDVITSVFEASNLLEQQ-------R 256
Cdd:cd12825   159 LRESLIEKQRII---------TLLLKSPRENSDTKEKLKIEL-------RDLSSLLDHTTFNFDKLDDLKNNilgkielE 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1150786867 257 QGTITRQLAAWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12825   223 QNKIIKIFTVVTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTILPLLYFKRKGWL 287
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 34-320 2.09e-22

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 94.58  E-value: 2.09e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFVIAK--TAQLEGDQITYGETAIFVGKRYIITVRN 111
Cdd:cd11744     1 WIHCERLHDDDIRRVLEDNLHVPRALEDILLAESRPSFHPLDDNFMIILRgfNMDENASPEDMLSVRILYFQGALISTRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 112 GSERGHGELRGRLeASPKTLCHGTDYILHAILDFIIDGYLPIVRTIED-----AVLDMERKMLDAFLDRSQITRI-FKLR 185
Cdd:cd11744    81 IPSRAFMEIRQRL-REHSKGPKSAASLLNQLIEGLNGKIDLYLETIEEtlnelDVNDEEGHYDESTYNHIALQKAlISIR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 186 REVILFQRVLDAMLDlcgklyhlDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEASNLLEQQRQGTITRQLA 265
Cdd:cd11744   160 RFIRPQQYALRDLIR--------SESELVTSRPHQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFT 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1150786867 266 AWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARW 320
Cdd:cd11744   232 LVATIFLPTTFLAGLYGMNFEGMPGVESSMAFTWFCIALIVAFGLEWLLFKRKGF 286
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 34-321 4.50e-18

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 83.08  E-value: 4.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDNQLFV----IAKTAQLEGDQITYGETAIFVGKRYIITV 109
Cdd:cd12829     1 WLDVQSPTDDDMRAIGKLFPIHPLTLEDILSQDTREKVELFPNYYFIsfraIESDSELDENVLEPVNVYIVVFREGILTF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 110 RNGSERGHGELRGRLEASPKTLCHGTDYILHAILDFIIDGYLPIVRTIEDAVLDMErKMLDAFLDRSQ---ITRIFKLRR 186
Cdd:cd12829    81 HFKPLDHIERVRKRIRLLSDSHLLSSDWVLYALLDSIVDSFFPLVDSIEKEVDSID-ELVLLISSSDQsdlLRRIGDLRR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 187 EVILFQRVLDAMLDLCGKL----YHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFeaSNLLEQ------QR 256
Cdd:cd12829   160 RVTSLLRLLFAKSDVLKQLlkrlMKKTFVSPDSEVAIYLGDVQDHILTLLQKLNHYEDLLSRSH--SNYLAQlslemsQE 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1150786867 257 QGTIT---RQLAAWAAILAVPTAIAGIYGMNFdNMP-ELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12829   238 SNGTDkamLRLTVIATIFLPLQLITGLFGMNV-KVPgQDIESLYWFFGIVIVAIMVLVAIVVVFLVRRW 305
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 33-321 5.09e-18

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 82.58  E-value: 5.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  33 IWIGLHKPSRDELLLLQSRFGLH-----ELSIADALSslqmpKLSVYDNQLFViakTAQL--EGDQITYGETAI-FV-GK 103
Cdd:cd12837     1 VWIDLLNPTPEEEAAVEALLGIAiptreEMSEIEASS-----RLYREGGALYM---TAPLlsRADTDDPELSPVtFVlTP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 104 RYIITVRngsergHGELR------GRLEASPKTlCHGTDYILHAILDFIIDgylpivRT---IEDAVLDMERKMLDAFLD 174
Cdd:cd12837    73 ERLVTVR------YADPRafdtfaARAARQPSG-CASGEDVLLGLLEAIVD------RLadvLERVGADLDRLSRRIFRS 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 175 RSQITRIFKLRREVILfqRVLDAMLDLCGKLyHLDLPSLDREAkPYFRDALQH------MHRVETMvasLRDViTSVFEA 248
Cdd:cd12837   140 SAKRRRRASRDLRSVL--RRIGRAGDLLSKI-RESLLSLGRLL-SFLSANAADwlskelRARLKTL---QRDV-ASLSEH 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 249 SNLLEQQ--------------RQGTITRQLAAWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIR 314
Cdd:cd12837   212 ATFLSNKiqflldatlgliniEQNNIIKIFSVASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVLPLLW 291


                  ....*..
gi 1150786867 315 FKRARWI 321
Cdd:cd12837   292 FKRRGWL 298
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 34-321 1.47e-17

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 81.01  E-value: 1.47e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  34 WIGLHKPSRDELLLLQSRFGLHELSIADALSSLQMPKLSVYDN--QLFVIAKTAQLEGDQITYGET---AIFVGKRYIIT 108
Cdd:cd12827     1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDtdYLLIILDVPVEEEEDDDEYETiplGIILTKDRLIT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 109 VRNG-----SERGHGELRGRLEASPktlchgTDYILHaILDFIIDGYLPIVRTIedavlDMERKMLDAFLDRS----QIT 179
Cdd:cd12827    81 ICNHetdllDDFLEGRVKNFDTSSK------TRFLLQ-ILYRIATSYLKYLRQI-----NKERDELEQELRKStknkELF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 180 RIFKLRREVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFEA-SNLLeQQRQG 258
Cdd:cd12827   149 QLLDLEKSLVYFSTSLKSNEIVLEKLKRSRSLKLDEEDKELLEDVIIENKQAIEMAEIYSDILSGLMDAfASVI-SNNLN 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1150786867 259 TITRQLAAWAAILAVPTAIAGIYGMNFDnMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12827   228 NVMKFLTSITIVLTIPTIITGFYGMNVP-LPFADSPYAFWIILLISLLLSVIVALILRRKKYF 289
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 138-321 1.75e-16

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 77.99  E-value: 1.75e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 138 ILHAILDFIIDGYLPIVRTIEDAVLDMERKMLDAFLDRSQiTRIFKLRREVILFQRVLDAMLDLCGKLYHLDLPSLDREA 217
Cdd:cd12826    99 FLYDFLEYLIKDDLEYLEKYEEKLEELEEEILDGKLKNFN-ERILKIRKELLRLNSYYEQLMDIGEELEENENDLFDEEE 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 218 KPYFRDALQHMHRVETMVASLRDVITSVFEAsnlleQQ-----RQGTITRqlaawaaILAVPTA-------IAGIYGMNF 285
Cdd:cd12826   178 LRLFRLFSDRVERLHDNVQMLREYSLQIREL-----YQsqidiRQNRIMK-------ILTVVTTiflpltlITGWYGMNF 245

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1150786867 286 DNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12826   246 TNMPELHWKYGYPVVIILSILIVVIEIIYFKKKKWL 281
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 32-321 8.85e-16

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 76.14  E-value: 8.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  32 FIWIGLHKPSRDELLLLQSRFGLHELSIADalsSLQMPKLSVY-DNQLFVIAKTAQLEGDQITY-GETAIFVGKR-YIIT 108
Cdd:cd12836     1 VLWIDLINPTEEEIKTVEQYFNIEFPTKQE---SEEIESSSRYwEDEDSITINSNFLVPDDDGYhNEPVSFILKDnILFT 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 109 VRNGSERGHGELRGRLEASPKTLCHGTDyILHAILDFIIDGYLPIVRTIEDAVLDMERKML-DAFLDRSQITRI------ 181
Cdd:cd12836    78 IRYGELRTFSETSKKLRANPKKFQTGYD-IFSSILEIRIDYDADLLENISKEISKLRKKLFaDEDLDEELLEKIsrlqel 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 182 -FKLRREVILFQRVLDAMLDLcgklyhldlPSLDREAKPYFRDALQHmhrvetmVASLRDVITSVFEASNLL-------- 252
Cdd:cd12836   157 nMTIRENLIDKQRVLSSLLKS---------EKFPEDLKENLRIMIKD-------INSLIEHTTFNFERLDYLqntflgli 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1150786867 253 --EQQRqgtITRQLAAWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12836   221 niEQNK---IIKIFTVATVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 224-321 2.38e-12

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 66.13  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 224 ALQHMHRvETMVASLRDV------ITSVFEASNLLEQQRQG-------TITRQLAAWAAILAVPTAIAGIYGMNFDNMPE 290
Cdd:cd12835   178 RLSDEQL-EDAREILRDIesllphTQFLFDKINFLMDAAMGfinieqnKIIKIFSVAAVVFLPPTLIASIYGMNFDFMPE 256

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1150786867 291 LKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12835   257 LDWKFGYPMAIGLMILSAIAPYLYFKRKGWL 287
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 99-320 3.47e-11

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 62.99  E-value: 3.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  99 IFVGKRYIITVRNGSERGHGELRGRLE--ASPKTLCHGTDYILHAILDFIIDgylpIVRTIEDAVLDMERKMLDAFLDRS 176
Cdd:cd12834    71 FAVTPRLLITARRQPLRSVDRLRQAVErgLRFRSPADLLEHLLREQADTLSR----IVRELTDELDRIEDRLLSGRLRRE 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 177 QiTRIFKLRREVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVITSVFE--ASNLLEQ 254
Cdd:cd12834   147 R-RELGALRRRLVRLHRLLAPEPAALFRLLRRPPDWLPDADLETLRRLTERLDALDRDLVALQERARLLQEeiAARLAEQ 225

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1150786867 255 QRQGTITrqLAAWAAILAVPTAIAGIYGMNFDNMPELKTSYGYFIVLAVIA-IMCIALFIRFKRARW 320
Cdd:cd12834   226 TNRSLYI--LSVVTALLLPPTLVTGLFGMNTGGLPLAEGPHGFWIAVALALlAAGLAYLLLRRLGLL 290
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 99-321 5.69e-11

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 62.13  E-value: 5.69e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  99 IFVGKRYIITVRNGSERGHGELRGRLEAS--PKTLCHgtdyILHAILDFIIDGYLPIVRTIEDAVLDMERKMLD--AFLD 174
Cdd:cd12833    71 LWITPGRIISTRRRRLLAVDDIREALEAGkgPKSPGD----FLAALAERLTDRMEDVIDELEDRLDELEERVLEeeDEEL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 175 RSQITRifkLRREVILFQRVL----DAMLdlcgKLYHLDLPSLDREAKPYFRDALQHMHR-VETMVASLrdvitsvfEAS 249
Cdd:cd12833   147 RGELAE---LRRQAIALRRYLapqrDALE----RLAREDLPWLSDDDRLRLREAADRLTRyIEDLDAIR--------ERA 211

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1150786867 250 NLLEQQRQGTITRQLAAWAAILAVPTAI-------AGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFKRARWI 321
Cdd:cd12833   212 AVLQEELTNRRAEQMNRRMYVLSIVAAIflplgflTGLLGINVGGIPGAENPWAFWIFCGLLVVLAVGLLLLFRRKKWL 290
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
244-321 7.50e-09

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 55.88  E-value: 7.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 244 SVFEASNLLEQQRQGTITRQLAAWAAILAV-------PTAIAGIYGMNFDNMPELKTSYGYFIVLAVIAIMCIALFIRFK 316
Cdd:PRK11085  232 SLFQKVNFLMQAAMGFINIEQNRIIKIFSVvsvvflpPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFK 311


                  ....*
gi 1150786867 317 RARWI 321
Cdd:PRK11085  312 RKNWL 316
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 99-317 7.73e-09

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 55.99  E-value: 7.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867  99 IFVGKRYIITVRNGSERGHGELRGRL--EASPKTLCHGTDYILHAILDFIIDgylpIVRTIEDAVLDMERKMLDAFLDRS 176
Cdd:cd12824    71 ILIGQGAAVTVRSGPSRAVDELRRALrdHSSLKSLADLLAQMISGMTKRLEL----VIFDLTETLDEVEDNLLDGGTAPP 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 177 QIT------RIFKLRREVILFQRVLDAMLDLCGKLYHLDLPSLDREAKPYFRDALQHMHRVETMVASLRDVItsvfeasn 250
Cdd:cd12824   147 PYAlialqrRLFRIRRQIRPQQQALRPLITDPAELLVTSDRETLRRASNNVTRYLETLDFCRTRVALLQDEI-------- 218

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1150786867 251 llEQQRQGTITRQLAAWA--AILAVPTA-IAGIYGMNFDNMPELKTSYGY-FIVLAVIAIMCIALFIRFKR 317
Cdd:cd12824   219 --KAQRDEKTTRSSLLLTvvATVFLPLTfITGLLGMNVGGIPDVESPMGFwWVTGLSILVALLAWLLLRRL 287
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 153-321 1.41e-04

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 43.00  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 153 IVRTIEDAVLDMERKmLDAFLDRSQitrifKLRREvilFQRVLDAMLDLCGkLYHLDLPSlDREAKPYFRDALQH----- 227
Cdd:cd12823   148 ISTSNLERLLPLKRR-LVELETRVQ-----KVRDA---LEELLDDDEDMAD-MYLTDKAA-GPERLESSRKEDDHeevem 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1150786867 228 -----MHRVETM---VASLRDVITSVFEASNL-LEQQRQgTITR---QLAAWAAILAVPTAIAGIYGMNFDNMPElKTSY 295
Cdd:cd12823   217 lleayLQQVDELlnkLEELREYIDDTEELINLiLDSRRN-QLMRlelKLSIGTLSLAVGTLVAGLFGMNLPSGLE-ESPY 294

                         170       180
                  ....*....|....*....|....*..
gi 1150786867 296 GYFIVLAVIAIMCIALFIRFKR-ARWI 321
Cdd:cd12823   295 AFWIVTGGSVVGSILIFIVVLRyLRRK 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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