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Conserved domains on  [gi|1151110088|ref|WP_078082388|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Priestia]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11441299)

NAD(P)/FAD-dependent oxidoreductase catalyzes the transfer of electrons from one molecule, the electron donor or reductant, to another molecule, the electron acceptor or oxidant; similar to sulfide:quinone oxidoreductase which catalyzes the oxidation of hydrogen sulfide using quinone as the electron acceptor

EC:  1.6.-.-
Gene Ontology:  GO:0003954|GO:0006116
PubMed:  15590775|28181562

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
17-392 1.77e-133

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


:

Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 387.18  E-value: 1.77e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  17 AAMKAREHLNEnDAKITMVNRFSTHQIITELHRLAAGSISEKAVSLPLDKLLKNYHVDLKISTVNGISPNKHEVSLEDGT 96
Cdd:COG1252    16 AARRLRKKLGG-DAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTLADGR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  97 TLTYDYLVVALGSETAYFDIPGLKENSFVLKSVEDANRLRTHVEERIAEYSKtnnKAAGTIVVGGAGLTGTELVGEYADL 176
Cdd:COG1252    95 TLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER---RRLLTIVVVGGGPTGVELAGELAEL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 177 MPSLSLKYGVDPKGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRVDGKIVELKDGRKIETETLVWAG 256
Cdd:COG1252   172 LRKLLRYPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDGEEIPADTVIWAA 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 257 GVQGNSVVANSNMEVSR-GRVLVNEFLQPPSQDDIFVAGDSAVVMGPDGTTYPPTAQLAWQMGENIGVNLAISIRGGVLK 335
Cdd:COG1252   252 GVKAPPLLADLGLPTDRrGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRGKPLK 331

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1151110088 336 PFVPIFSGTLASLGRKDAVGTVGenKTELKGVPAALMKQASDVRYLSHIKGLFSLAY 392
Cdd:COG1252   332 PFRYRDKGCLASLGRGAAVADVG--GLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
17-392 1.77e-133

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 387.18  E-value: 1.77e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  17 AAMKAREHLNEnDAKITMVNRFSTHQIITELHRLAAGSISEKAVSLPLDKLLKNYHVDLKISTVNGISPNKHEVSLEDGT 96
Cdd:COG1252    16 AARRLRKKLGG-DAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTLADGR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  97 TLTYDYLVVALGSETAYFDIPGLKENSFVLKSVEDANRLRTHVEERIAEYSKtnnKAAGTIVVGGAGLTGTELVGEYADL 176
Cdd:COG1252    95 TLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER---RRLLTIVVVGGGPTGVELAGELAEL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 177 MPSLSLKYGVDPKGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRVDGKIVELKDGRKIETETLVWAG 256
Cdd:COG1252   172 LRKLLRYPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDGEEIPADTVIWAA 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 257 GVQGNSVVANSNMEVSR-GRVLVNEFLQPPSQDDIFVAGDSAVVMGPDGTTYPPTAQLAWQMGENIGVNLAISIRGGVLK 335
Cdd:COG1252   252 GVKAPPLLADLGLPTDRrGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRGKPLK 331

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1151110088 336 PFVPIFSGTLASLGRKDAVGTVGenKTELKGVPAALMKQASDVRYLSHIKGLFSLAY 392
Cdd:COG1252   332 PFRYRDKGCLASLGRGAAVADVG--GLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 71-359 1.32e-36

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 137.98  E-value: 1.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  71 YHVDLKISTVNGISPNKHEVSLEDGTTLTYDYLVVALGSETAYFDIPGLKENSFVLKSVEDANRLRTHVEERIAEYSKTN 150
Cdd:PTZ00318   85 YDVDFEEKRVKCGVVSKSNNANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPT 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 151 -----NKAAGTIVVGGAGLTGTELVGEYADLMPSLSLKygVDPKgISLYC----VEASPTVLAGFPPKLVERAYTSLTKR 221
Cdd:PTZ00318  165 tsveeRKRLLHFVVVGGGPTGVEFAAELADFFRDDVRN--LNPE-LVEECkvtvLEAGSEVLGSFDQALRKYGQRRLRRL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 222 GVTFITGTPVTRVDGKIVELKDGRKIETETLVWAGGVQGNSVVANSNME-VSRGRVLVNEFLQPPSQDDIFVAGDSAVVm 300
Cdd:PTZ00318  242 GVDIRTKTAVKEVLDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDkTSRGRISVDDHLRVKPIPNVFALGDCAAN- 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 301 gpDGTTYPPTAQLAWQMGENIGVNLAISIRGGVL-KPFVPIFSGTLASLGRKDAVGTVGE 359
Cdd:PTZ00318  321 --EERPLPTLAQVASQQGVYLAKEFNNELKGKPMsKPFVYRSLGSLAYLGNYSAIVQLGA 378
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 17-318 1.63e-34

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 129.36  E-value: 1.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  17 AAMKAREHLNENDAKITMVNRFSTHQ----IITELHRLAAGSISE----KAVSLPLDKLLKNYHVDLKI---STVNGISP 85
Cdd:pfam07992  11 AGLAAALTLAQLGGKVTLIEDEGTCPyggcVLSKALLGAAEAPEIaslwADLYKRKEEVVKKLNNGIEVllgTEVVSIDP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  86 NKHEVSLE-----DGTTLTYDYLVVALGSETAYFDIPGLKENS-FVLKSVEDANRLRTH-VEERIAeysktnnkaagtiV 158
Cdd:pfam07992  91 GAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNVgFLVRTLDSAEALRLKlLPKRVV-------------V 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 159 VGGaGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRV---- 234
Cdd:pfam07992 158 VGG-GYIGVELAAALAKL-------------GKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIigdg 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 235 DGKIVELKDGRKIETETLVWAGGVQGNSVVA-NSNMEV-SRGRVLVNEFLQpPSQDDIFVAGDSAVVmgpdgttYPPTAQ 312
Cdd:pfam07992 224 DGVEVILKDGTEIDADLVVVAIGRRPNTELLeAAGLELdERGGIVVDEYLR-TSVPGIYAAGDCRVG-------GPELAQ 295


                  ....*.
gi 1151110088 313 LAWQMG 318
Cdd:pfam07992 296 NAVAQG 301
 
Name Accession Description Interval E-value
Ndh COG1252
NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];
17-392 1.77e-133

NADH dehydrogenase, FAD-containing subunit [Energy production and conversion];


Pssm-ID: 440864 [Multi-domain]  Cd Length: 386  Bit Score: 387.18  E-value: 1.77e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  17 AAMKAREHLNEnDAKITMVNRFSTHQIITELHRLAAGSISEKAVSLPLDKLLKNYHVDLKISTVNGISPNKHEVSLEDGT 96
Cdd:COG1252    16 AARRLRKKLGG-DAEVTLIDPNPYHLFQPLLPEVAAGTLSPDDIAIPLRELLRRAGVRFIQGEVTGIDPEARTVTLADGR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  97 TLTYDYLVVALGSETAYFDIPGLKENSFVLKSVEDANRLRTHVEERIAEYSKtnnKAAGTIVVGGAGLTGTELVGEYADL 176
Cdd:COG1252    95 TLSYDYLVIATGSVTNFFGIPGLAEHALPLKTLEDALALRERLLAAFERAER---RRLLTIVVVGGGPTGVELAGELAEL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 177 MPSLSLKYGVDPKGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRVDGKIVELKDGRKIETETLVWAG 256
Cdd:COG1252   172 LRKLLRYPGIDPDKVRITLVEAGPRILPGLGEKLSEAAEKELEKRGVEVHTGTRVTEVDADGVTLEDGEEIPADTVIWAA 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 257 GVQGNSVVANSNMEVSR-GRVLVNEFLQPPSQDDIFVAGDSAVVMGPDGTTYPPTAQLAWQMGENIGVNLAISIRGGVLK 335
Cdd:COG1252   252 GVKAPPLLADLGLPTDRrGRVLVDPTLQVPGHPNVFAIGDCAAVPDPDGKPVPKTAQAAVQQAKVLAKNIAALLRGKPLK 331

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1151110088 336 PFVPIFSGTLASLGRKDAVGTVGenKTELKGVPAALMKQASDVRYLSHIKGLFSLAY 392
Cdd:COG1252   332 PFRYRDKGCLASLGRGAAVADVG--GLKLSGFLAWLLKRAIHLYFLPGFRGRLRVLL 386
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 68-326 8.94e-39

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 141.10  E-value: 8.94e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  68 LKNYHVDLKI-STVNGISPNKHEVSLEDGTTLTYDYLVVALGSETAYFDIPGLK-ENSFVLKSVEDANRLRTHVEeriae 145
Cdd:COG0446    46 FERKGIDVRTgTEVTAIDPEAKTVTLRDGETLSYDKLVLATGARPRPPPIPGLDlPGVFTLRTLDDADALREALK----- 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 146 ysktnNKAAGTIVVGGAGLTGTELVgEYAdlmpslsLKYGVDpkgISLycVEASPTVLAGFPPKLVERAYTSLTKRGVTF 225
Cdd:COG0446   121 -----EFKGKRAVVIGGGPIGLELA-EAL-------RKRGLK---VTL--VERAPRLLGVLDPEMAALLEEELREHGVEL 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 226 ITGTPVTRVDGK---IVELKDGRKIETETLVWAGGVQGNSVVA-NSNMEV-SRGRVLVNEFLQpPSQDDIFVAGDSAVVM 300
Cdd:COG0446   183 RLGETVVAIDGDdkvAVTLTDGEEIPADLVVVAPGVRPNTELAkDAGLALgERGWIKVDETLQ-TSDPDVYAAGDCAEVP 261

                         250       260
                  ....*....|....*....|....*...
gi 1151110088 301 GP--DGTTYPPTAQLAWQMGENIGVNLA 326
Cdd:COG0446   262 HPvtGKTVYIPLASAANKQGRVAAENIL 289
PTZ00318 PTZ00318
NADH dehydrogenase-like protein; Provisional
 71-359 1.32e-36

NADH dehydrogenase-like protein; Provisional


Pssm-ID: 185553 [Multi-domain]  Cd Length: 424  Bit Score: 137.98  E-value: 1.32e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  71 YHVDLKISTVNGISPNKHEVSLEDGTTLTYDYLVVALGSETAYFDIPGLKENSFVLKSVEDANRLRTHVEERIAEYSKTN 150
Cdd:PTZ00318   85 YDVDFEEKRVKCGVVSKSNNANVNTFSVPYDKLVVAHGARPNTFNIPGVEERAFFLKEVNHARGIRKRIVQCIERASLPT 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 151 -----NKAAGTIVVGGAGLTGTELVGEYADLMPSLSLKygVDPKgISLYC----VEASPTVLAGFPPKLVERAYTSLTKR 221
Cdd:PTZ00318  165 tsveeRKRLLHFVVVGGGPTGVEFAAELADFFRDDVRN--LNPE-LVEECkvtvLEAGSEVLGSFDQALRKYGQRRLRRL 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 222 GVTFITGTPVTRVDGKIVELKDGRKIETETLVWAGGVQGNSVVANSNME-VSRGRVLVNEFLQPPSQDDIFVAGDSAVVm 300
Cdd:PTZ00318  242 GVDIRTKTAVKEVLDKEVVLKDGEVIPTGLVVWSTGVGPGPLTKQLKVDkTSRGRISVDDHLRVKPIPNVFALGDCAAN- 320

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 301 gpDGTTYPPTAQLAWQMGENIGVNLAISIRGGVL-KPFVPIFSGTLASLGRKDAVGTVGE 359
Cdd:PTZ00318  321 --EERPLPTLAQVASQQGVYLAKEFNNELKGKPMsKPFVYRSLGSLAYLGNYSAIVQLGA 378
NirB COG1251
NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];
47-326 6.49e-36

NAD(P)H-nitrite reductase, large subunit [Energy production and conversion];


Pssm-ID: 440863 [Multi-domain]  Cd Length: 402  Bit Score: 135.27  E-value: 6.49e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  47 LHRLAAGSISEKAVSLPLDKLLKNYHVDLKIST-VNGISPNKHEVSLEDGTTLTYDYLVVALGSETAYFDIPGL-KENSF 124
Cdd:COG1251    45 LSKVLAGETDEEDLLLRPADFYEENGIDLRLGTrVTAIDRAARTVTLADGETLPYDKLVLATGSRPRVPPIPGAdLPGVF 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 125 VLKSVEDANRLRTHVeeriaeysktnnKAAGTIVVGGAGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLA 204
Cdd:COG1251   125 TLRTLDDADALRAAL------------APGKRVVVIGGGLIGLEAAAALRKR-------------GLEVTVVERAPRLLP 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 205 G-FPPKLVERAYTSLTKRGVTFITGTPVTRVDG----KIVELKDGRKIETETLVWAGGVQGN-SVVANSNMEVSRGrVLV 278
Cdd:COG1251   180 RqLDEEAGALLQRLLEALGVEVRLGTGVTEIEGddrvTGVRLADGEELPADLVVVAIGVRPNtELARAAGLAVDRG-IVV 258

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1151110088 279 NEFLQpPSQDDIFVAGDSAVVMGP-DGTTYPPTAQLAWQMGENIGVNLA 326
Cdd:COG1251   259 DDYLR-TSDPDIYAAGDCAEHPGPvYGRRVLELVAPAYEQARVAAANLA 306
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 17-318 1.63e-34

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 129.36  E-value: 1.63e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  17 AAMKAREHLNENDAKITMVNRFSTHQ----IITELHRLAAGSISE----KAVSLPLDKLLKNYHVDLKI---STVNGISP 85
Cdd:pfam07992  11 AGLAAALTLAQLGGKVTLIEDEGTCPyggcVLSKALLGAAEAPEIaslwADLYKRKEEVVKKLNNGIEVllgTEVVSIDP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  86 NKHEVSLE-----DGTTLTYDYLVVALGSETAYFDIPGLKENS-FVLKSVEDANRLRTH-VEERIAeysktnnkaagtiV 158
Cdd:pfam07992  91 GAKKVVLEelvdgDGETITYDRLVIATGARPRLPPIPGVELNVgFLVRTLDSAEALRLKlLPKRVV-------------V 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 159 VGGaGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRV---- 234
Cdd:pfam07992 158 VGG-GYIGVELAAALAKL-------------GKEVTLIEALDRLLRAFDEEISAALEKALEKNGVEVRLGTSVKEIigdg 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 235 DGKIVELKDGRKIETETLVWAGGVQGNSVVA-NSNMEV-SRGRVLVNEFLQpPSQDDIFVAGDSAVVmgpdgttYPPTAQ 312
Cdd:pfam07992 224 DGVEVILKDGTEIDADLVVVAIGRRPNTELLeAAGLELdERGGIVVDEYLR-TSVPGIYAAGDCRVG-------GPELAQ 295


                  ....*.
gi 1151110088 313 LAWQMG 318
Cdd:pfam07992 296 NAVAQG 301
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 66-326 4.37e-20

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 91.30  E-value: 4.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  66 KLLKNYHVDLkistVNG----ISPnkHEVSLEDGTTLTYDYLVVALGSETAYFDIPGLKENsFVLKSvEDANRLrTHVEE 141
Cdd:COG1249    99 ELLKKNGVDV----IRGrarfVDP--HTVEVTGGETLTADHIVIATGSRPRVPPIPGLDEV-RVLTS-DEALEL-EELPK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 142 RIaeysktnnkaagtIVVGGaGLTGTELVGEYADLmpslslkyGVDpkgISLycVEASPTVLAGFPPKLVERAYTSLTKR 221
Cdd:COG1249   170 SL-------------VVIGG-GYIGLEFAQIFARL--------GSE---VTL--VERGDRLLPGEDPEISEALEKALEKE 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 222 GVTFITGTPVTRV----DGKIVELKDGRKIET---ETLVWAGGVQGNSV---VANSNMEVS-RGRVLVNEFLQpPSQDDI 290
Cdd:COG1249   223 GIDILTGAKVTSVektgDGVTVTLEDGGGEEAveaDKVLVATGRRPNTDglgLEAAGVELDeRGGIKVDEYLR-TSVPGI 301

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1151110088 291 FVAGDsavVMGPdgttyPPTAQLAWQMGENIGVNLA 326
Cdd:COG1249   302 YAIGD---VTGG-----PQLAHVASAEGRVAAENIL 329
PRK09754 PRK09754
phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional
 62-304 1.75e-15

phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional


Pssm-ID: 170080 [Multi-domain]  Cd Length: 396  Bit Score: 77.27  E-value: 1.75e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  62 LPLDKLLKNyHVDLKIS-TVNGISPNKHEVSLEDGTTLTYDYLVVALGSETAYFD-IPGLKENSFVLKSVEDANRLRTHV 139
Cdd:PRK09754   63 LPANWWQEN-NVHLHSGvTIKTLGRDTRELVLTNGESWHWDQLFIATGAAARPLPlLDALGERCFTLRHAGDAARLREVL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 140 EEriaeysktnnkaAGTIVVGGAGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLAGFPPKLVERAYTSL- 218
Cdd:PRK09754  142 QP------------ERSVVIVGAGTIGLELAASATQR-------------RCKVTVIELAATVMGRNAPPPVQRYLLQRh 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 219 TKRGVTFITGTP-VTRVDGKIVELK--DGRKIETETLVWAGGVQGNSVVANSNMEVSRGRVLVNEFLQpPSQDDIFVAGD 295
Cdd:PRK09754  197 QQAGVRILLNNAiEHVVDGEKVELTlqSGETLQADVVIYGIGISANDQLAREANLDTANGIVIDEACR-TCDPAIFAGGD 275


                  ....*....
gi 1151110088 296 SAVVMGPDG 304
Cdd:PRK09754  276 VAITRLDNG 284
PRK04965 PRK04965
NADH:flavorubredoxin reductase NorW;
38-297 1.17e-14

NADH:flavorubredoxin reductase NorW;


Pssm-ID: 179902 [Multi-domain]  Cd Length: 377  Bit Score: 74.57  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  38 FSTHQIITELHRLAAGSISEKavslpldkllknYHVDLKIST-VNGISPNKHEVsLEDGTTLTYDYLVVALGSETAYFDI 116
Cdd:PRK04965   50 FSQGQRADDLTRQSAGEFAEQ------------FNLRLFPHTwVTDIDAEAQVV-KSQGNQWQYDKLVLATGASAFVPPI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 117 PGLkENSFVLKSVEDanrLRTHvEERIAEysktnnkaAGTIVVGGAGLTGTELVgeyADLMPSlslkygvdpkGISLYCV 196
Cdd:PRK04965  117 PGR-ELMLTLNSQQE---YRAA-ETQLRD--------AQRVLVVGGGLIGTELA---MDLCRA----------GKAVTLV 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 197 EASPTVLAGF-PPKLVERAYTSLTKRGVTFITGTPVTRV----DGKIVELKDGRKIETETLVWAGGVQGNSVVAN-SNME 270
Cdd:PRK04965  171 DNAASLLASLmPPEVSSRLQHRLTEMGVHLLLKSQLQGLektdSGIRATLDSGRSIEVDAVIAAAGLRPNTALARrAGLA 250

                         250       260
                  ....*....|....*....|....*..
gi 1151110088 271 VSRGrVLVNEFLQpPSQDDIFVAGDSA 297
Cdd:PRK04965  251 VNRG-IVVDSYLQ-TSAPDIYALGDCA 275
PRK06416 PRK06416
dihydrolipoamide dehydrogenase; Reviewed
 64-302 1.61e-14

dihydrolipoamide dehydrogenase; Reviewed


Pssm-ID: 235798 [Multi-domain]  Cd Length: 462  Bit Score: 74.80  E-value: 1.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  64 LDKLLKNYHVDLkistVNG----ISPNKHEVSLEDG-TTLTYDYLVVALGSETayFDIPGLKENSFVLKSVEDANRLrTH 138
Cdd:PRK06416   98 VEGLLKKNKVDI----IRGeaklVDPNTVRVMTEDGeQTYTAKNIILATGSRP--RELPGIEIDGRVIWTSDEALNL-DE 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 139 VEERIaeysktnnkaagtIVVGGaGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLAGFPP---KLVERAy 215
Cdd:PRK06416  171 VPKSL-------------VVIGG-GYIGVEFASAYASL-------------GAEVTIVEALPRILPGEDKeisKLAERA- 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 216 tsLTKRGVTFITGTPVTRV----DGKIVELKDGRKIET---ETLVWAGGVQGNSvvANSNME-----VSRGRVLVNEFLQ 283
Cdd:PRK06416  223 --LKKRGIKIKTGAKAKKVeqtdDGVTVTLEDGGKEETleaDYVLVAVGRRPNT--ENLGLEelgvkTDRGFIEVDEQLR 298

                         250
                  ....*....|....*....
gi 1151110088 284 pPSQDDIFVAGDsaVVMGP 302
Cdd:PRK06416  299 -TNVPNIYAIGD--IVGGP 314
PRK05249 PRK05249
Si-specific NAD(P)(+) transhydrogenase;
72-302 1.08e-12

Si-specific NAD(P)(+) transhydrogenase;


Pssm-ID: 235373 [Multi-domain]  Cd Length: 461  Bit Score: 69.03  E-value: 1.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  72 HVDLKISTVNGISPNKHEVSLEDGT--TLTYDYLVVALGSETAY-----FDipglkeNSFVLKSVEdanrlrthveerIA 144
Cdd:PRK05249  108 RVDLIQGRARFVDPHTVEVECPDGEveTLTADKIVIATGSRPYRppdvdFD------HPRIYDSDS------------IL 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 145 EYSKTnnkaAGTIVVGGAGLTGTElvgeYADLMPSLSLKygVDpkgislyCVEASPTVLAGFPPKLVERAYTSLTKRGVT 224
Cdd:PRK05249  170 SLDHL----PRSLIIYGAGVIGCE----YASIFAALGVK--VT-------LINTRDRLLSFLDDEISDALSYHLRDSGVT 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 225 FITGTPVTRV----DGKIVELKDGRKIETETLVWAGGVQGNsvVANSNMEV------SRGRVLVNEFLQpPSQDDIFVAG 294
Cdd:PRK05249  233 IRHNEEVEKVeggdDGVIVHLKSGKKIKADCLLYANGRTGN--TDGLNLENagleadSRGQLKVNENYQ-TAVPHIYAVG 309


                  ....*...
gi 1151110088 295 DsavVMGP 302
Cdd:PRK05249  310 D---VIGF 314
PRK09564 PRK09564
coenzyme A disulfide reductase; Reviewed
 99-351 1.64e-11

coenzyme A disulfide reductase; Reviewed


Pssm-ID: 181958 [Multi-domain]  Cd Length: 444  Bit Score: 65.45  E-value: 1.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  99 TYDYLVVALGSETAYFDIPGLK-ENSFVLKSVEDANRLRthveeriAEYSKTNNKaagTIVVGGAGLTGTELVGEYADLM 177
Cdd:PRK09564  103 TYDKLMIATGARPIIPPIKNINlENVYTLKSMEDGLALK-------ELLKDEEIK---NIVIIGAGFIGLEAVEAAKHLG 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 178 PSLSLkygvdpkgislycVEASPTVLAG-FPPKLVERAYTSLTKRGVTFITGTPVTRVDG----KIVElKDGRKIETETL 252
Cdd:PRK09564  173 KNVRI-------------IQLEDRILPDsFDKEITDVMEEELRENGVELHLNEFVKSLIGedkvEGVV-TDKGEYEADVV 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 253 VWAGGVQGNS-VVANSNME-VSRGRVLVNEFLQPpSQDDIFVAGDSAVV--MGPDGTTYPPTAQLAWQMGENIGVNLAis 328
Cdd:PRK09564  239 IVATGVKPNTeFLEDTGLKtLKNGAIIVDEYGET-SIENIYAAGDCATIynIVSNKNVYVPLATTANKLGRMVGENLA-- 315

                         250       260
                  ....*....|....*....|...
gi 1151110088 329 irGGVLKpfvpiFSGTLASLGRK 351
Cdd:PRK09564  316 --GRHVS-----FKGTLGSACIK 331
Pyr_redox pfam00070
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 157-244 1.46e-07

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 425450 [Multi-domain]  Cd Length: 80  Bit Score: 48.35  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 157 IVVGGAGLTGTELVGEYADLmpslslkygvdpkGISLYCVEASPTVLAGFPPKLVERAYTSLTKRGVTFITGTPVTRV-- 234
Cdd:pfam00070   2 VVVVGGGYIGLELAGALARL-------------GSKVTVVERRDRLLPGFDPEIAKILQEKLEKNGIEFLLNTTVEAIeg 68

                          90
                  ....*....|..
gi 1151110088 235 --DGKIVELKDG 244
Cdd:pfam00070  69 ngDGVVVVLTDG 80
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 83-295 1.63e-07

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 52.87  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  83 ISPNKHEVsleDGTTLTYDYLVVALGSETAYfdIPGLK--ENSFVLKSvEDANRLRThVEERIAeysktnnkaagtIVVG 160
Cdd:PRK06292  117 VDPNTVEV---NGERIEAKNIVIATGSRVPP--IPGVWliLGDRLLTS-DDAFELDK-LPKSLA------------VIGG 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 161 GA-GLtgtelvgEYADLMPSLslkyGVDPKGIslycvEASPTVLAGFPPKLVERAYTSLTKRgVTFITGTPVTRV----D 235
Cdd:PRK06292  178 GViGL-------ELGQALSRL----GVKVTVF-----ERGDRILPLEDPEVSKQAQKILSKE-FKIKLGAKVTSVeksgD 240

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1151110088 236 GKIVELKDG---RKIETETLVWAGGVQGNS---VVANSNMEV-SRGRVLVNEFLQpPSQDDIFVAGD 295
Cdd:PRK06292  241 EKVEELEKGgktETIEADYVLVATGRRPNTdglGLENTGIELdERGRPVVDEHTQ-TSVPGIYAAGD 306
PRK13512 PRK13512
coenzyme A disulfide reductase; Provisional
 69-351 1.65e-05

coenzyme A disulfide reductase; Provisional


Pssm-ID: 184103 [Multi-domain]  Cd Length: 438  Bit Score: 46.70  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088  69 KNYHvdlkisTVNGISPNKHEVSLEDGTT-----LTYDYLVVALGsetAYFDIPGLKEN-SFVLKSVEDANRLRTHVEer 142
Cdd:PRK13512   76 KTYH------EVIAINDERQTVTVLNRKTneqfeESYDKLILSPG---ASANSLGFESDiTFTLRNLEDTDAIDQFIK-- 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 143 iaeysktNNKAAGTIVVGGAGLtgtelvgeyadlmpSLSLKYGVDPKGISLYCVEASPTVLAGFPPKLVERAYTSLTKRG 222
Cdd:PRK13512  145 -------ANQVDKALVVGAGYI--------------SLEVLENLYERGLHPTLIHRSDKINKLMDADMNQPILDELDKRE 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 223 VTFITGTPVTRVDGKIVELKDGrKIETETLVWAG-GVQGNS-VVANSNMEVSR-GRVLVNEFLQpPSQDDIFVAGDSAVv 299
Cdd:PRK13512  204 IPYRLNEEIDAINGNEVTFKSG-KVEHYDMIIEGvGTHPNSkFIESSNIKLDDkGFIPVNDKFE-TNVPNIYAIGDIIT- 280

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1151110088 300 mgpdgTTY-----PPTAQLAWQ-------MGENIGVNLAISIRGGVLKPFVPIFSGTLASLGRK 351
Cdd:PRK13512  281 -----SHYrhvdlPASVPLAWGahraasiVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVK 339
FadH2 COG0446
NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase ...
 187-255 1.23e-03

NADPH-dependent 2,4-dienoyl-CoA reductase, sulfur reductase, or a related oxidoreductase [Lipid transport and metabolism];


Pssm-ID: 440215 [Multi-domain]  Cd Length: 322  Bit Score: 40.56  E-value: 1.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1151110088 187 DPKGISLYcveasptVLAGFPP--KLVERAYTSLTKRGVTFITGTPVTRVD--GKIVELKDGRKIETETLVWA 255
Cdd:COG0446    20 QPCGLPYY-------VGGGIKDpeDLLVRTPESFERKGIDVRTGTEVTAIDpeAKTVTLRDGETLSYDKLVLA 85
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 222-303 4.28e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 39.09  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1151110088 222 GVTFITGTPVTRVDG--------------KIVELKDGR---------KIETETLVWAGGVQGNSVV--ANSNMEVSRGRV 276
Cdd:PRK12771  319 GVEINWLRTPVEIEGdengatglrvitveKMELDEDGRpspvtgeeeTLEADLVVLAIGQDIDSAGleSVPGVEVGRGVV 398

                          90       100
                  ....*....|....*....|....*..
gi 1151110088 277 LVNEFLQPPSQDDIFVAGDsaVVMGPD 303
Cdd:PRK12771  399 QVDPNFMMTGRPGVFAGGD--MVPGPR 423
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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