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Conserved domains on  [gi|1152378280|ref|WP_078247210|]
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lytic transglycosylase domain-containing protein [Helicobacter pylori]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 13014034)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 89-219 6.51e-60

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 189.65  E-value: 6.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  89 LIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQTGEWY 168
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1152378280 169 LVAMAYNYGLRKVQNAIKAAGTSdikILLDEDKKYLPKETREYIRSILSLA 219
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTD---KWEDYYRLYLPAETRRYVPKFLAAK 128
mltD super family cl32574
membrane-bound lytic murein transglycosylase D; Provisional
 95-365 2.81e-38

membrane-bound lytic murein transglycosylase D; Provisional


The actual alignment was detected with superfamily member PRK10783:

Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 142.57  E-value: 2.81e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  95 PQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQ-TGEWYLVAMA 173
Cdd:PRK10783  118 PMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQRLNKMfDGDWLLTVAA 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 174 YNYGLRKVQNAIKA----AGTSDIKILldedkkYLPKETREYIRSILSLA--LKFNSLDNLK----DKEYLLnrgARVSl 243
Cdd:PRK10783  198 YNSGEGRVMKAIKAnkakGKPTDFWSL------SLPRETKIYVPKMLALSdiLKNSKRYGVRlpttDESRAL---ARVD- 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 244 VGVPFKrhtsLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYtIYIPYEKLALFK-----------QRQLKQNKSIQA 312
Cdd:PRK10783  268 LGQQIE----LAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHY-IMVPKKHADQLReslasgeiaavQSTLVADNTPLN 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1152378280 313 SSkspfiTHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTN 365
Cdd:PRK10783  343 SR-----SYKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAG 390
 
Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 89-219 6.51e-60

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 189.65  E-value: 6.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  89 LIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQTGEWY 168
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1152378280 169 LVAMAYNYGLRKVQNAIKAAGTSdikILLDEDKKYLPKETREYIRSILSLA 219
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTD---KWEDYYRLYLPAETRRYVPKFLAAK 128
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 95-365 2.81e-38

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 142.57  E-value: 2.81e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  95 PQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQ-TGEWYLVAMA 173
Cdd:PRK10783  118 PMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQRLNKMfDGDWLLTVAA 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 174 YNYGLRKVQNAIKA----AGTSDIKILldedkkYLPKETREYIRSILSLA--LKFNSLDNLK----DKEYLLnrgARVSl 243
Cdd:PRK10783  198 YNSGEGRVMKAIKAnkakGKPTDFWSL------SLPRETKIYVPKMLALSdiLKNSKRYGVRlpttDESRAL---ARVD- 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 244 VGVPFKrhtsLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYtIYIPYEKLALFK-----------QRQLKQNKSIQA 312
Cdd:PRK10783  268 LGQQIE----LAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHY-IMVPKKHADQLReslasgeiaavQSTLVADNTPLN 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1152378280 313 SSkspfiTHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTN 365
Cdd:PRK10783  343 SR-----SYKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAG 390
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 84-196 4.73e-37

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 129.73  E-value: 4.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  84 IIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQ 163
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1152378280 164 TGE-WYLVAMAYNYGLRKVQNAIKAAGTSDIKIL 196
Cdd:pfam01464  81 YGGdLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 58-222 4.89e-34

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 126.26  E-value: 4.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  58 ALKKVNKEEEWKKLVKRFDVNYQfiPIIKNMLIEASVPQEFLF-LAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKV 136
Cdd:COG0741    82 IAALAAELLALAALLLRRPLPYL--PLIEEAAKKYGVDPALVLaLIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 137 N--HYIDERRDPIKSTQAAITYLKRLYKQ-TGEWYLVAMAYNYGLRKVQNAIKAAGTSDIKIlldedkkyLP-KETREYI 212
Cdd:COG0741   160 GlgPSPDDLFDPETNIRAGAAYLRELLDRfDGDLVLALAAYNAGPGRVRRWLRRNGDRDGEI--------IPyAETRNYV 231

                         170
                  ....*....|
gi 1152378280 213 RSILSLALKF 222
Cdd:COG0741   232 KKVLANYAIY 241
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
209-365 1.17e-13

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 68.20  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 209 REYIRSILSLALKFNSLDNLKDKEYLLNRGARVSLVGVPFKRHTSLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYT 288
Cdd:COG1388     5 ALSANAALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPEAAAAAAA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1152378280 289 IYIPYEKLALFKQRqlkqnKSIQASSKSPFITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTN 365
Cdd:COG1388    85 RYTVKSGDTLSGIA-----RRYGAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIPAS 156
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 321-363 8.74e-12

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 59.33  E-value: 8.74e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1152378280 321 HVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIP 363
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 319-362 3.99e-09

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 51.72  E-value: 3.99e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1152378280 319 ITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSN-IFIHQRLII 362
Cdd:cd00118     1 KTYTVKPGDTLWSIAKKYGVTVEELAAANPLINPDcIYPGQKLKI 45
LysM smart00257
Lysin motif;
320-362 2.39e-08

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 49.75  E-value: 2.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1152378280  320 THVVLPKETLSSIAKRYQVSISSIQLANNLKDSN-IFIHQRLII 362
Cdd:smart00257   1 TYTVKKGDTLSSIARRYGISVSDLLELNNILDPDnLQVGQKLKI 44
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 68-217 2.23e-04

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 43.13  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  68 WKKLVKRFDVNYQfiPIIKNMLIEASVPQEFlflAMA----ESKFSSRAYSRKKAVGIWQFMPSTA----KELGLKvnHY 139
Cdd:PRK11619  468 WDHLEERFPLAWN--DEFRRYTSGKGIPQSY---AMAiarqESAWNPKARSPVGASGLMQIMPGTAthtvKMFSIP--GY 540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 140 IDERR--DPIKSTQAAITYLKRLYKQTGEWYLVA-MAYNYGLRKVQNAIK-AAGTSDIKILLDEdkkyLP-KETREYIRS 214
Cdd:PRK11619  541 SSSSQllDPETNINIGTSYLEYVYQQFGNNRILAsAAYNAGPGRVRTWLGnSAGRIDAVAFVES----IPfSETRGYVKN 616


                  ...
gi 1152378280 215 ILS 217
Cdd:PRK11619  617 VLA 619
 
Name Accession Description Interval E-value
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 89-219 6.51e-60

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 189.65  E-value: 6.51e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  89 LIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQTGEWY 168
Cdd:cd16894     1 LLKEGLPEELKYLALVESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDERRDPEKSTRAAARYLKDLYKRFGDWL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1152378280 169 LVAMAYNYGLRKVQNAIKAAGTSdikILLDEDKKYLPKETREYIRSILSLA 219
Cdd:cd16894    81 LALAAYNAGEGRVRRAIKRAGTD---KWEDYYRLYLPAETRRYVPKFLAAK 128
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 95-365 2.81e-38

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 142.57  E-value: 2.81e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  95 PQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQ-TGEWYLVAMA 173
Cdd:PRK10783  118 PMELVLLPIVESAFDPHATSGANAAGIWQIIPSTGRNYGLKQTRWYDARRDVVASTTAALDMMQRLNKMfDGDWLLTVAA 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 174 YNYGLRKVQNAIKA----AGTSDIKILldedkkYLPKETREYIRSILSLA--LKFNSLDNLK----DKEYLLnrgARVSl 243
Cdd:PRK10783  198 YNSGEGRVMKAIKAnkakGKPTDFWSL------SLPRETKIYVPKMLALSdiLKNSKRYGVRlpttDESRAL---ARVD- 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 244 VGVPFKrhtsLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYtIYIPYEKLALFK-----------QRQLKQNKSIQA 312
Cdd:PRK10783  268 LGQQIE----LAQAAEMAGMSLTKLKTFNAGYKRSTTAPSGPHY-IMVPKKHADQLReslasgeiaavQSTLVADNTPLN 342

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1152378280 313 SSkspfiTHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTN 365
Cdd:PRK10783  343 SR-----SYKVRSGDTLSGIASRLNVSTKDLQQWNNLRGSKLKVGQTLTIGAG 390
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 84-196 4.73e-37

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 129.73  E-value: 4.73e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  84 IIKNMLIEASVPQEFLFLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNHYIDERRDPIKSTQAAITYLKRLYKQ 163
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDDLFDPEKNIKAGTKYLKELYKQ 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1152378280 164 TGE-WYLVAMAYNYGLRKVQNAIKAAGTSDIKIL 196
Cdd:pfam01464  81 YGGdLWLALAAYNAGPGRVRKWIKNAGAKDKKLL 114
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 58-222 4.89e-34

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 126.26  E-value: 4.89e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  58 ALKKVNKEEEWKKLVKRFDVNYQfiPIIKNMLIEASVPQEFLF-LAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGLKV 136
Cdd:COG0741    82 IAALAAELLALAALLLRRPLPYL--PLIEEAAKKYGVDPALVLaLIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 137 N--HYIDERRDPIKSTQAAITYLKRLYKQ-TGEWYLVAMAYNYGLRKVQNAIKAAGTSDIKIlldedkkyLP-KETREYI 212
Cdd:COG0741   160 GlgPSPDDLFDPETNIRAGAAYLRELLDRfDGDLVLALAAYNAGPGRVRRWLRRNGDRDGEI--------IPyAETRNYV 231

                         170
                  ....*....|
gi 1152378280 213 RSILSLALKF 222
Cdd:COG0741   232 KKVLANYAIY 241
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 80-217 2.14e-25

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 106.30  E-value: 2.14e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  80 QFIPIIKNMLIEASVPQEFL-FLAMAESKFSSRAYSRKKAVGIWQFMPSTAKELGlkvnhyIDERRDPIKSTQAAITYLK 158
Cdd:COG4623   263 PYDPLFEKYAEEYGLDWRLLaALAYQESHWNPRARSPTGARGLMQLMPATAKELG------VDDRLDPEQSIRAGAKYLR 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 159 RLYKQ-------TGEWYLVAMAYNYGLRKVQNAIKAAGT--------SDIKillDEDKKYL------PKETREYIRSILS 217
Cdd:COG4623   337 WLYDRfpeaidePDRWWFALAAYNAGPGHVQDARRLAKKqgldpdrwFDVE---KSQPKYYdtgyarGRETVNYVPNIRA 413
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 97-217 6.49e-20

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 84.19  E-value: 6.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  97 EFLFLAM--AESKFSSRAYSRKKAVGIWQFMPSTAKELGLKVNhyiDERRDPIKSTQAAITYLKRLYKQT-GEWYLVAMA 173
Cdd:cd00254     1 PALVLAVirVESGFNPRAVSPAGARGLMQLMPGTARDLGRRGV---DDLFDPEENIRAGARYLRELLDRFgGDLELALAA 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1152378280 174 YNYGLRKVQNAIKAAgtsdikilldedkKYLPKETREYIRSILS 217
Cdd:cd00254    78 YNAGPGAVDRWGGGE-------------VPPYKETRNYVQRVLA 108
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 81-217 3.05e-17

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 77.90  E-value: 3.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  81 FIPIIKNMLIEASVPQEFLF-LAMAESKFSSRAYSRKKAVGIWQFMPSTAKE----LGLKVNHyIDERRDPIKSTQAAIT 155
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYaIIRQESAFDPDAVSPAGALGLMQLMPATAKDvakkLGLPYYS-PRDLFDPEYNIRLGSA 84

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1152378280 156 YLKRLYKQT-GEWYLVAMAYNYGLRKVQNAIKAAGTSDIkillDEDKKYLP-KETREYIRSILS 217
Cdd:cd13401    85 YLAELLDRFdGNPVLALAAYNAGPGRVRRWLKRRGDLDP----DLWIETIPfSETRNYVKRVLE 144
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 100-216 3.38e-15

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 72.16  E-value: 3.38e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 100 FLAMA----ESKFSSRAYSRKKAVGIWQFMPSTA----KELGLKVNHYiDERRDPIKSTQAAITYLKRLYKQ-TGEWYLV 170
Cdd:cd16896    20 LLVAAvikvESNFNPNAVSSKGAIGLMQIMPETAewiaEKLGLEDFSE-DDLYDPETNIRLGTWYLSYLLKEfDGNLVLA 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1152378280 171 AMAYNYGLRKVQNAIKAAGTSDIKILLDedkKYLPKETREYIRSIL 216
Cdd:cd16896    99 LAAYNAGPGNVDKWLKDGGWSGDGKTLD---QIPFPETRHYVKKVL 141
LysM COG1388
LysM repeat [Cell wall/membrane/envelope biogenesis];
209-365 1.17e-13

LysM repeat [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440998 [Multi-domain]  Cd Length: 156  Bit Score: 68.20  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 209 REYIRSILSLALKFNSLDNLKDKEYLLNRGARVSLVGVPFKRHTSLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYT 288
Cdd:COG1388     5 ALSANAALLAAVLTLLAALLLLAAALAAVALLLLAALAPAGLSLAAALNGEALLLLLPAAAAAAKAALAAAPEAAAAAAA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1152378280 289 IYIPYEKLALFKQRqlkqnKSIQASSKSPFITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIPTN 365
Cdd:COG1388    85 RYTVKSGDTLSGIA-----RRYGAAAAPSPVTYTVKKGDTLWSIARRYGVSVEELKRWNGLSSDTIRPGQKLKIPAS 156
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 102-217 3.33e-12

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 64.09  E-value: 3.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 102 AMA--ESKFSSRAYSRKKAVGIWQFMPSTAKELGlkvnhyIDERRDPIKSTQAAITYLKRLYKQTGE-------WYLVAM 172
Cdd:cd13403    17 AQAyqESRFNPNARSPAGARGLMQLMPSTARELG------VNDRLDPEQNIHAGAKYLRYLRDRFPPdidepdrLKFALA 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1152378280 173 AYNYGLRKVQNAIKAA----GTSDI------KILLDEDKKYLPK---------ETREYIRSILS 217
Cdd:cd13403    91 AYNAGPGHVRDARRLAkkygLNPNVwfdnveVLPLLKSPYYDPVvkygyargrETVNYVRNIRK 154
LysM pfam01476
LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety ...
 321-363 8.74e-12

LysM domain; The LysM (lysin motif) domain is about 40 residues long. It is found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function. The structure of this domain is known.


Pssm-ID: 396179 [Multi-domain]  Cd Length: 43  Bit Score: 59.33  E-value: 8.74e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1152378280 321 HVVLPKETLSSIAKRYQVSISSIQLANNLKDSNIFIHQRLIIP 363
Cdd:pfam01476   1 YTVKKGDTLSSIAKRYGITVEQLAELNGLSSPNLYVGQKLKIP 43
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 101-177 4.37e-10

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 56.55  E-value: 4.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 101 LAMAESKFSSRAY-SRKKAVGIWQFMPSTAKELGLKVNHyiDERRDPiKSTQAAIT----YLKRLYKQTGEWY-----LV 170
Cdd:cd13399    11 ILGVESGFGPNAGgSPAGAQGIAQFMPSTWKAYGVDGNG--DGKADP-FNPEDAIAsaanYLCRHGWDLNAFLgednfLA 87


                  ....*..
gi 1152378280 171 AMAYNYG 177
Cdd:cd13399    88 LAAYNAG 94
LysM cd00118
Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain ...
 319-362 3.99e-09

Lysin Motif is a small domain involved in binding peptidoglycan; LysM, a small globular domain with approximately 40 amino acids, is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls, but proteins involved in many other biological functions also contain this domain. It has been reported that the LysM domain functions as a signal for specific plant-bacteria recognition in bacterial pathogenesis. Many of these enzymes are modular and are composed of catalytic units linked to one or several repeats of LysM domains. LysM domains are found in bacteria and eukaryotes.


Pssm-ID: 212030 [Multi-domain]  Cd Length: 45  Bit Score: 51.72  E-value: 3.99e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1152378280 319 ITHVVLPKETLSSIAKRYQVSISSIQLANNLKDSN-IFIHQRLII 362
Cdd:cd00118     1 KTYTVKPGDTLWSIAKKYGVTVEELAAANPLINPDcIYPGQKLKI 45
LysM smart00257
Lysin motif;
320-362 2.39e-08

Lysin motif;


Pssm-ID: 197609 [Multi-domain]  Cd Length: 44  Bit Score: 49.75  E-value: 2.39e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1152378280  320 THVVLPKETLSSIAKRYQVSISSIQLANNLKDSN-IFIHQRLII 362
Cdd:smart00257   1 TYTVKKGDTLSSIARRYGISVSDLLELNNILDPDnLQVGQKLKI 44
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 101-156 1.23e-04

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 39.70  E-value: 1.23e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1152378280 101 LAMAESKFSSRAY--SRKKAVGIWQFMPSTAKELGlKVNHyiDERRDPIKSTQAAITY 156
Cdd:cd00442     5 IIGQESGGNKPANagSGSGAAGLFQFMPGTWKAYG-KNSS--SDLNDPEASIEAAAKY 59
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 68-217 2.23e-04

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 43.13  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  68 WKKLVKRFDVNYQfiPIIKNMLIEASVPQEFlflAMA----ESKFSSRAYSRKKAVGIWQFMPSTA----KELGLKvnHY 139
Cdd:PRK11619  468 WDHLEERFPLAWN--DEFRRYTSGKGIPQSY---AMAiarqESAWNPKARSPVGASGLMQIMPGTAthtvKMFSIP--GY 540

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 140 IDERR--DPIKSTQAAITYLKRLYKQTGEWYLVA-MAYNYGLRKVQNAIK-AAGTSDIKILLDEdkkyLP-KETREYIRS 214
Cdd:PRK11619  541 SSSSQllDPETNINIGTSYLEYVYQQFGNNRILAsAAYNAGPGRVRTWLGnSAGRIDAVAFVES----IPfSETRGYVKN 616


                  ...
gi 1152378280 215 ILS 217
Cdd:PRK11619  617 VLA 619
PRK06347 PRK06347
1,4-beta-N-acetylmuramoylhydrolase;
253-360 3.21e-04

1,4-beta-N-acetylmuramoylhydrolase;


Pssm-ID: 180536 [Multi-domain]  Cd Length: 592  Bit Score: 42.76  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280 253 SLIQVAKNLNLSLETLKSYNHQFRYNILPSKDPTYTIYIPYEKLALFKQRQLKQNKSIQASSKSPFITHVVLPKETLSSI 332
Cdd:PRK06347  340 SLWRIANNHKVTVANLKAWNNLKSDFIYPGQKLKVSAGSTTSDTNTSKPSTGTSTSKPSTGTSTNAKVYTVVKGDSLWRI 419

                          90       100
                  ....*....|....*....|....*...
gi 1152378280 333 AKRYQVSISSIQLANNLKDSNIFIHQRL 360
Cdd:PRK06347  420 ANNNKVTIANLKSWNNLKSDFIYPGQKL 447
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 99-218 8.62e-03

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 36.77  E-value: 8.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152378280  99 LFLAM--AESKFSSRAYSRKKAVGIWQFMPSTAkelGLKVNHYI---------DERRDPIKSTQAAITYLKRLYKQ---- 163
Cdd:cd16893    16 LILAIieTESSFNPYAVSHSPAYGLMQIVPSTA---GRDVYRLLggkgglpskSYLFDPENNIDIGTAYLHILQNRylkg 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1152378280 164 ----TGEWYLVAMAYNYGL--------RKVQNAIKAAGTSDIKILLDEDKKYLP-KETREYIRSILSL 218
Cdd:cd16893    93 iknpKSREYCAIAAYNGGAgnvlrtfsSDRKKAISKINRLSPDEVYQHLTKKLPaAETRNYLKKVLKA 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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