NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1152435476|ref|WP_078295345|]
View 

nucleotide exchange factor GrpE [Helicobacter pylori]

Protein Classification

nucleotide exchange factor GrpE( domain architecture ID 10793982)

nucleotide exchange factor GrpE functions as a nucleotide exchange factor for DnaK and participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may also function as a thermosensor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 1-190 6.28e-104

heat shock protein GrpE; Provisional


:

Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 296.78  E-value: 6.28e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   1 MKDEHNQEHD-LSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 79
Cdd:PRK14149    1 MKDEHNQEHDhLSQKEPESEEKACACKEQQGEEKQEASEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  80 LEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 159
Cdd:PRK14149   81 LEYAYEKIALDLLPVIDALLGALKSAAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1152435476 160 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 190
Cdd:PRK14149  161 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 191
 
Name Accession Description Interval E-value
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 1-190 6.28e-104

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 296.78  E-value: 6.28e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   1 MKDEHNQEHD-LSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 79
Cdd:PRK14149    1 MKDEHNQEHDhLSQKEPESEEKACACKEQQGEEKQEASEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  80 LEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 159
Cdd:PRK14149   81 LEYAYEKIALDLLPVIDALLGALKSAAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1152435476 160 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 190
Cdd:PRK14149  161 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-188 1.03e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 168.02  E-value: 1.03e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  45 EDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEK 124
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1152435476 125 LHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:COG0576    82 LLDVLEKHGVEEIEPVgEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE pfam01025
GrpE;
26-188 5.26e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 166.63  E-value: 5.26e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  26 KGQQGEEKQEAHEKEGEIrEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSA 105
Cdd:pfam01025   3 KKNEEALTDEIESLEEEI-EELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 106 VEVDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMV 184
Cdd:pfam01025  82 PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEgEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMV 161


                  ....
gi 1152435476 185 SIAK 188
Cdd:pfam01025 162 VVSK 165
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 52-186 7.37e-52

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 162.68  E-value: 7.37e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  52 KEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLAR 131
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKNLLEGVEMTLKQLLKVLEK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1152435476 132 HGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 186
Cdd:cd00446    81 HGVEEIEPEgEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
 
Name Accession Description Interval E-value
PRK14149 PRK14149
heat shock protein GrpE; Provisional
 1-190 6.28e-104

heat shock protein GrpE; Provisional


Pssm-ID: 184538 [Multi-domain]  Cd Length: 191  Bit Score: 296.78  E-value: 6.28e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   1 MKDEHNQEHD-LSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 79
Cdd:PRK14149    1 MKDEHNQEHDhLSQKEPESEEKACACKEQQGEEKQEASEKEGEIKEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  80 LEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 159
Cdd:PRK14149   81 LEYAYEKIALDLLPVIDALLGALKSAAEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEK 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1152435476 160 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 190
Cdd:PRK14149  161 ENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 191
GrpE COG0576
Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein ...
 45-188 1.03e-53

Molecular chaperone GrpE (heat shock protein HSP-70) [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440341 [Multi-domain]  Cd Length: 147  Bit Score: 168.02  E-value: 1.03e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  45 EDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEK 124
Cdd:COG0576     2 EELEAELAELKDRLLRLQAEFENYRKRTEREREEARKYALEKLAEDLLPVLDNLERALAAAEEDEDVKSLLEGVEMTLKQ 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1152435476 125 LHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:COG0576    82 LLDVLEKHGVEEIEPVgEPFDPNLHEAVSQVPSPDVEPGTVVEVLQKGYRLGDRVLRPAMVVVAK 146
GrpE pfam01025
GrpE;
26-188 5.26e-53

GrpE;


Pssm-ID: 425996 [Multi-domain]  Cd Length: 165  Bit Score: 166.63  E-value: 5.26e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  26 KGQQGEEKQEAHEKEGEIrEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSA 105
Cdd:pfam01025   3 KKNEEALTDEIESLEEEI-EELEKKIEELKEKLLRALAEFENLRKRTEKEKEEAKKFAIEKFAKDLLPVIDNLERALNSA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 106 VEVDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMV 184
Cdd:pfam01025  82 PENEDVKSLLEGVEMTLKQLLKILEKHGVEKIEPEgEPFDPNLHEAVSQVPSPEKPEGTVVEVLQKGYKLHDRVLRPAMV 161


                  ....
gi 1152435476 185 SIAK 188
Cdd:pfam01025 162 VVSK 165
GrpE cd00446
nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70) ...
 52-186 7.37e-52

nucleotide exchange factor GrpE; GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. In bacteria, the DnaK-DnaJ-GrpE (KJE) chaperone system functions at the fulcrum of protein homeostasis. GrpE participates actively in response to heat shock by preventing aggregation of stress-denatured proteins; unfolded proteins initially bind to DnaJ, the J-domain ATPase-activating protein (Hsp40 family), whereupon DnaK hydrolyzes its bound ATP, resulting in a stable complex. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding. In eukaryotes, only the mitochondrial Hsp70, not the cytosolic form, is GrpE dependent. Over-expression of Hsp70 molecular chaperones is important in suppressing toxicity of aberrantly folded proteins that occur in Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis, as well as several polyQ-diseases such as Huntington's disease and ataxias.


Pssm-ID: 271355 [Multi-domain]  Cd Length: 136  Bit Score: 162.68  E-value: 7.37e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  52 KEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLAR 131
Cdd:cd00446     1 KELKDKLLRAQAEFENYRKRTEKEKEEAKKYAIEKFAKDLLPVLDNLERALEAAPKEEELKNLLEGVEMTLKQLLKVLEK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1152435476 132 HGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSI 186
Cdd:cd00446    81 HGVEEIEPEgEKFDPNLHEAVMQVESPDKEPGTVVEVLQKGYKLHDRVLRPAMVVV 136
PRK14140 PRK14140
heat shock protein GrpE; Provisional
 31-188 2.89e-35

heat shock protein GrpE; Provisional


Pssm-ID: 237622 [Multi-domain]  Cd Length: 191  Bit Score: 122.42  E-value: 2.89e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  31 EEKQEAHEKEGEIREdFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAhkSAVEVDK 110
Cdd:PRK14140   34 SEAELLDEEQAKIAE-LEAKLDELEERYLRLQADFENYKRRIQKENEAAEKYRAQSLASDLLPALDNFERA--LQIEADD 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 111 ESA--LTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIA 187
Cdd:PRK14140  111 EQTksLLKGVEMVHRQLLEALKKEGVEVIEAVgEQFDPNLHQAVMQDEDEDFESNEVVEELQKGYKLKDRVIRPSMVKVN 190


                  .
gi 1152435476 188 K 188
Cdd:PRK14140  191 Q 191
PRK14159 PRK14159
heat shock protein GrpE; Provisional
 28-188 1.67e-30

heat shock protein GrpE; Provisional


Pssm-ID: 172647 [Multi-domain]  Cd Length: 176  Bit Score: 109.78  E-value: 1.67e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  28 QQGEEKQEAHEKEGEIREDFELK--YKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSA 105
Cdd:PRK14159   14 ENSEHLQDENLQNIEDVEQNKLQkdYDELKDKYMRANAEFENIKKRMEKEKLSAMAYANESFAKDLLDVLDALEAAVNVE 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 106 VEVDKESALTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVS 185
Cdd:PRK14159   94 CHDEISLKIKEGVQNTLDLFLKKLEKHGVALIKEEKEFDPNLHEAMFHVDSENHQSGEVVQVLQKGYKIADRVIRPTKVS 173


                  ...
gi 1152435476 186 IAK 188
Cdd:PRK14159  174 VAK 176
PRK14141 PRK14141
heat shock protein GrpE; Provisional
 1-188 2.20e-29

heat shock protein GrpE; Provisional


Pssm-ID: 172630  Cd Length: 209  Bit Score: 107.83  E-value: 2.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   1 MKDEHNQ-EHDLSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKykemhEKYLRVHADFENVKKRLERDKSMA 79
Cdd:PRK14141    1 MTDEKNKnGNPADAARDANNPVDREAKPYEMEDDPEPDPLEALKAENAELK-----DRMLRLAAEMENLRKRTQRDVADA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  80 LEYAYEKIALDLLPVIDALLGAHKSAVEVDKESA------LTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIM 152
Cdd:PRK14141   76 RAYGIAGFARDMLSVSDNLRRALDAIPAEARAAAdaglkaLIEGVEMTERAMLNALERHGVKKLDPEgQKFDPNFHQAMF 155

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1152435476 153 QVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14141  156 EVPNPDVPNNTVVQVVQAGYTIGERVLRPAMVGVAK 191
PRK14151 PRK14151
heat shock protein GrpE; Provisional
 32-188 1.93e-28

heat shock protein GrpE; Provisional


Pssm-ID: 172640 [Multi-domain]  Cd Length: 176  Bit Score: 104.47  E-value: 1.93e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  32 EKQEAHEKEGEIREDFELKYKEMHEKY-------LRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDAL-LGAHK 103
Cdd:PRK14151   10 QAPEAAQAEAAAGDDLTARVQELEEQLaaakdqsLRAAADLQNVRRRAEQDVEKAHKFALEKFAGDLLPVVDSLeRGLEL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 104 SAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPA 182
Cdd:PRK14151   90 SSADDEAIKPMREGVELTLKMFQDTLKRYQLEAVDPHgEPFNPEHHQAMAMQESADVEPNSVLKVFQKGYLLNGRLLRPA 169


                  ....*.
gi 1152435476 183 MVSIAK 188
Cdd:PRK14151  170 MVVVSK 175
PRK14162 PRK14162
heat shock protein GrpE; Provisional
 4-188 2.94e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237631 [Multi-domain]  Cd Length: 194  Bit Score: 101.84  E-value: 2.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   4 EHNQEHDLSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIrEDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYA 83
Cdd:PRK14162    9 EKDLPQEETTDEAPKKEAKEAPKEEDQEKQNPVEDLEKEI-ADLKAKNKDLEDKYLRSQAEIQNMQNRYAKERAQLIKYE 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  84 YEKIALDLLPVIDALLGAhkSAVEVDKESA--LTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSE-EK 159
Cdd:PRK14162   88 SQSLAKDVLPAMDNLERA--LAVKADDEAAkqLKKGVQMTLDHLVKALKDHGVTEIKADgEKFDPTLHQAVQTVAAEnDD 165

                         170       180
                  ....*....|....*....|....*....
gi 1152435476 160 ENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14162  166 QKDHVVQVLQKGYQYKDRTLRPAMVVVAQ 194
PRK14139 PRK14139
heat shock protein GrpE; Provisional
 4-188 8.85e-27

heat shock protein GrpE; Provisional


Pssm-ID: 237621 [Multi-domain]  Cd Length: 185  Bit Score: 100.43  E-value: 8.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   4 EHNQEHDLSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREdFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYA 83
Cdd:PRK14139    2 ENTQQNPSEQEAEEAGAAAQAAAAAAAAAEDAAPALEAELAE-AEAKAAELQDSFLRAKAETENVRRRAQEDVAKAHKFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  84 YEKIALDLLPVIDALLGAhkSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENg 162
Cdd:PRK14139   81 IESFAESLLPVKDSLEAA--LADESGDLEKLREGVELTLKQLTSAFEKGRVVEINPVgEKFDPHQHQAISMVPAEQEPN- 157

                         170       180
                  ....*....|....*....|....*.
gi 1152435476 163 KIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14139  158 TVVAVLQKGYTIADRVLRPALVTVAA 183
PRK14147 PRK14147
heat shock protein GrpE; Provisional
 59-190 1.42e-26

heat shock protein GrpE; Provisional


Pssm-ID: 237625 [Multi-domain]  Cd Length: 172  Bit Score: 99.64  E-value: 1.42e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  59 LRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVevDKESALTKGLELTMEKLHEVLARHGIEGIE 138
Cdd:PRK14147   42 LRERADLENQRKRIARDVEQARKFANEKLLGELLPVFDSLDAGLTAAG--TEPSPLRDGLELTYKQLLKVAADNGLTLLD 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1152435476 139 CL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKND 190
Cdd:PRK14147  120 PVgQPFNPEHHQAISQGEAEGVAPGHVVQVFQKGYLLNERLLRPALVVVAKQD 172
PRK14153 PRK14153
heat shock protein GrpE; Provisional
 5-189 9.25e-26

heat shock protein GrpE; Provisional


Pssm-ID: 184540 [Multi-domain]  Cd Length: 194  Bit Score: 97.99  E-value: 9.25e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   5 HNQEHDLSPKEPESYQKACTCKGQQGEEKQEAHEK-EGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYA 83
Cdd:PRK14153    2 TSKEVGKDKAENSEARNSGSSAEEAEELKEEPEDStADSETEKCREEIESLKEQLFRLAAEFDNFRKRTAREMEENRKFV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  84 YEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIEC-LEEFDPNFHNAIMQVKSEEKENG 162
Cdd:PRK14153   82 LEQVLLDLLEVTDNFERALESARTAEDMNSIVEGIEMVSKQFFSILEKYGLERIECeGEEFDPHRHEAMMHVETSEVPDN 161

                         170       180
                  ....*....|....*....|....*..
gi 1152435476 163 KIVQVLQQGYKYKGRVLRPAMVSIAKN 189
Cdd:PRK14153  162 TIVDVCKPGYALNSKVIRPAMVSVARN 188
PRK14155 PRK14155
heat shock protein GrpE; Provisional
 31-187 1.08e-25

heat shock protein GrpE; Provisional


Pssm-ID: 237627 [Multi-domain]  Cd Length: 208  Bit Score: 98.11  E-value: 1.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  31 EEKQEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDK 110
Cdd:PRK14155    9 EDGPFEADDAAQEIEALKAEVAALKDQALRYAAEAENTKRRAEREMNDARAYAIQKFARDLLGAADNLGRATAASPKDSA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 111 ESALTK---GLELTMEKLHEVLARHGIEGIECL--EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVS 185
Cdd:PRK14155   89 DPAVKNfiiGVEMTEKELLGAFERNGLKKIDPAkgDKFDPHLHQAMMEQPSTEVAAGGVLQVMQAGYELMGRLVRPAMVA 168


                  ..
gi 1152435476 186 IA 187
Cdd:PRK14155  169 VA 170
PRK10325 PRK10325
heat shock protein GrpE; Provisional
 56-188 4.92e-25

heat shock protein GrpE; Provisional


Pssm-ID: 182379 [Multi-domain]  Cd Length: 197  Bit Score: 96.28  E-value: 4.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  56 EKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKE-SALTKGLELTMEKLHEVLARHGI 134
Cdd:PRK10325   60 DGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDmSAMVEGIELTLKSMLDVVRKFGV 139

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1152435476 135 EGI-ECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK10325  140 EVIaETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAK 194
PRK14150 PRK14150
heat shock protein GrpE; Provisional
 6-188 1.48e-24

heat shock protein GrpE; Provisional


Pssm-ID: 184539 [Multi-domain]  Cd Length: 193  Bit Score: 94.60  E-value: 1.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   6 NQEHDLSPKEPESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYE 85
Cdd:PRK14150    9 PQEQVSEEIEAEVEQQEEADEAELEDELDEADARIAELEAQLAEAQAEERDSVLRARAEVENIRRRAEQDVEKAHKFALE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  86 KIALDLLPVID----ALLGAHKSAVEVdkeSALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQVKSEEKE 160
Cdd:PRK14150   89 KFANELLPVIDnlerALQAADKENEAL---KALIEGVELTLKSLLDTVAKFGVEVVgPVGEPFNPEVHQAISMQESEDHE 165

                         170       180
                  ....*....|....*....|....*...
gi 1152435476 161 NGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14150  166 PNTVMMVMQKGYTLNGRLLRPAMVMVSK 193
PRK14148 PRK14148
heat shock protein GrpE; Provisional
 34-189 4.99e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172637 [Multi-domain]  Cd Length: 195  Bit Score: 93.66  E-value: 4.99e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  34 QEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESA 113
Cdd:PRK14148   39 EEQLERAKDTIKELEDSCDQFKDEALRAKAEMENIRKRAERDVSNARKFGIEKFAKELLPVIDSIEQALKHEVKLEEAIA 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1152435476 114 LTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAKN 189
Cdd:PRK14148  119 MKEGIELTAKMLVDILKKNGVEELDPKgEKFDPNLHEAMAMIPNPEFEDNTIFDVFQKGYMLNGRIVRAAKVVIVKN 195
PRK14158 PRK14158
heat shock protein GrpE; Provisional
 26-188 5.06e-24

heat shock protein GrpE; Provisional


Pssm-ID: 172646 [Multi-domain]  Cd Length: 194  Bit Score: 93.46  E-value: 5.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  26 KGQQGEEKQEAHEKEGEIRE-DFELKYKEMH-----EKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALL 99
Cdd:PRK14158   25 AAQGKPEAAQPVAAADRIKElEEALAAKEAEaaanwDKYLRERADLENYRKRVQKEKEELLKYGNESLILEILPAVDNME 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 100 GAHKSAVEvDKESALTKGLELTMEKLHEVLARHGIEGIECLE--EFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGR 177
Cdd:PRK14158  105 RALDHADE-ESMSAIIEGIRMTLSMLLSTLKKFGVTPVEAEKgtPFDPAYHQAMCQVESAEQEPNTVVAVFQKGYLLNER 183

                         170
                  ....*....|.
gi 1152435476 178 VLRPAMVSIAK 188
Cdd:PRK14158  184 LLRPAMVSVAT 194
PRK14144 PRK14144
heat shock protein GrpE; Provisional
 2-188 1.81e-23

heat shock protein GrpE; Provisional


Pssm-ID: 184535 [Multi-domain]  Cd Length: 199  Bit Score: 92.10  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   2 KDEHNQEHdlsPKEPESYQKACTCKGQQGEEKQEaHEKEGEIREDFELKYKEMHE---KYLRVHADFENVKKRLERDKSM 78
Cdd:PRK14144   13 KDEHKEEH---KVENEILEEETDEESQHQEPALG-HPSYTALEEQLTLAEQKAHEnweKSVRALAELENVRRRMEREVAN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  79 ALEYAYEKIALDLLPVIDALLGAHKSAVEvDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSE 157
Cdd:PRK14144   89 AHKYGVEKLISALLPVVDSLEQALQLADK-NSDPSMHEGLELTMKLFLDALQKFDVEQIDPLgQTFDPQQHEAMSMQPAP 167

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1152435476 158 EKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14144  168 GAPPNSVITVFQKGYKLSDRVIRPARVIVST 198
PRK14154 PRK14154
heat shock protein GrpE; Provisional
 27-187 2.18e-23

heat shock protein GrpE; Provisional


Pssm-ID: 237626 [Multi-domain]  Cd Length: 208  Bit Score: 92.18  E-value: 2.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  27 GQQGEEKQEAHEK----------EGEIREdFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVID 96
Cdd:PRK14154   35 GGDGSQEMEPHREglefpsreklEGQLTR-MERKVDEYKTQYLRAQAEMDNLRKRIEREKADIIKFGSKQLITDLLPVAD 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  97 ALL-GAHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGIECL--EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYK 173
Cdd:PRK14154  114 SLIhGLESPASEDPQVKSMRDGMSLTLDLLHNTLAKHGVQVINPNpgDPFDPALHEAMSVQAVPDAKPDTIIQVLQKGYQ 193

                         170
                  ....*....|....
gi 1152435476 174 YKGRVLRPAMVSIA 187
Cdd:PRK14154  194 LNGRVLRAARVIVA 207
PRK14161 PRK14161
heat shock protein GrpE; Provisional
 34-188 2.23e-20

heat shock protein GrpE; Provisional


Pssm-ID: 237630 [Multi-domain]  Cd Length: 178  Bit Score: 83.48  E-value: 2.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  34 QEAHEKEGEIREDFELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGA--HKSAVEVDKE 111
Cdd:PRK14161   18 EEIVETANPEITALKAEIEELKDKLIRTTAEIDNTRKRLEKARDEAKDYAIATFAKELLNVSDNLSRAlaHKPANSDVEV 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1152435476 112 SALTKGLELTMEKLHEVLARHGIEGI--ECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14161   98 TNIIAGVQMTKDELDKVFHKHHIEEIkpEIGSMFDYNLHNAISQIEHPDHAPNSIITLMQSGYKIRDRLLRPATVQVVK 176
PRK14145 PRK14145
heat shock protein GrpE; Provisional
 2-188 2.27e-20

heat shock protein GrpE; Provisional


Pssm-ID: 184536 [Multi-domain]  Cd Length: 196  Bit Score: 83.82  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   2 KDEHNQEHDLSPKEpESYQKACTCKGQQGEEKQEAHEKEGEIREDFELKYKEMHEkYL----RVHADFENVKKRLERDKS 77
Cdd:PRK14145   10 KEEEKDVNNLSSNE-QMEGPPEDEQAQQNQPQQQTVDEIEELKQKLQQKEVEAQE-YLdiaqRLKAEFENYRKRTEKEKS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  78 MALEYAYEKIALDLLPVIDALLGAHKSAVEvdkESALTKGLELTMEKLHEVLARHGIEGIECLEE-FDPNFHNAIMQVKS 156
Cdd:PRK14145   88 EMVEYGKEQVILELLPVMDNFERALASSGD---YNSLKEGIELIYRQFKKILDKFGVKEIEAEGQiFDPYKHHAVMQEEV 164

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1152435476 157 EEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14145  165 EGKQPNEIIEVFQKGYYLKDKVIRPSLVKVAK 196
PRK14160 PRK14160
heat shock protein GrpE; Provisional
 31-188 3.89e-19

heat shock protein GrpE; Provisional


Pssm-ID: 237629 [Multi-domain]  Cd Length: 211  Bit Score: 80.95  E-value: 3.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  31 EEKQEAHEKEGEIREDFELKYKEMHEK-----------YLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALL 99
Cdd:PRK14160   46 EDSEESNEVKIEELKDENNKLKEENKKlenelealkdrLLRTVAEYDNYRKRTAKEKEGIYSDACEDVLKELLPVLDNLE 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 100 GAhkSAVEVDKESaLTKGLELTMEKLHEVLARHGIEGIECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVL 179
Cdd:PRK14160  126 RA--AAVEGSVED-LKKGIEMTVKQFKTSLEKLGVEEISTEGEFDPNLHNAVMHVEDENYGENEIVEVFQKGYKRGDKVI 202


                  ....*....
gi 1152435476 180 RPAMVSIAK 188
Cdd:PRK14160  203 RYSMVKVAN 211
PRK14143 PRK14143
heat shock protein GrpE; Provisional
 52-187 4.53e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237624 [Multi-domain]  Cd Length: 238  Bit Score: 75.92  E-value: 4.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  52 KEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKS-AVEVDKESALTKGLELTMEKLHEVLA 130
Cdd:PRK14143   84 EELNSQYMRIAADFDNFRKRTSREQEDLRLQLKCNTLSEILPVVDNFERARQQlKPEGEEAQALHRSYQGLYKQLVDVLK 163

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1152435476 131 RHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIA 187
Cdd:PRK14143  164 RLGVSPMRVVgQEFDPNLHEAVLREPSDEHPEDVVLEELQRGYHLGGRVLRHAMVKVS 221
PRK14163 PRK14163
heat shock protein GrpE; Provisional
 60-188 4.68e-17

heat shock protein GrpE; Provisional


Pssm-ID: 184546 [Multi-domain]  Cd Length: 214  Bit Score: 75.55  E-value: 4.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  60 RVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVEVDKESALTKGLELTMEKLHevLARHGIEGiec 139
Cdd:PRK14163   65 RLQAEYQNYRRRVERDRVTVKEIAVANLLSELLPVLDDVGRAREHGELVGGFKSVAESLETTVAKLG--LQQFGKEG--- 139

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1152435476 140 lEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14163  140 -EPFDPTIHEALMHSYAPDVTETTCVAILQPGYRIGERTIRPARVAVAE 187
PRK14156 PRK14156
heat shock protein GrpE; Provisional
 1-188 7.89e-17

heat shock protein GrpE; Provisional


Pssm-ID: 237628 [Multi-domain]  Cd Length: 177  Bit Score: 74.10  E-value: 7.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476   1 MKDEHNQEHDLSPKEPESYQKACTCKGQQGEEKQEAhEKEGEIREDFElkykemhEKYLRVHADFENVKKRLERDKSMAL 80
Cdd:PRK14156    1 MSEEIKNEEVEEEVEATETEETVEEVVEETPEKSEL-ELANERADEFE-------NKYLRAHAEMQNIQRRANEERQQLQ 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  81 EYAYEKIALDLLPVIDALLGAhkSAVEVDKESaLTKGLELTMEKLHEVLARHGIEGIEcLEEFDPNFHNAIMQVKS-EEK 159
Cdd:PRK14156   73 RYRSQDLAKAILPSLDNLERA--LAVEGLTDD-VKKGLEMVQESLIQALKEEGVEEVA-VDSFDHNLHMAVQTLPAdDEH 148

                         170       180
                  ....*....|....*....|....*....
gi 1152435476 160 ENGKIVQVLQQGYKYKGRVLRPAMVSIAK 188
Cdd:PRK14156  149 PADSIAQVFQKGYKLHERLLRPAMVVVYN 177
PRK14164 PRK14164
heat shock protein GrpE; Provisional
 48-187 1.08e-15

heat shock protein GrpE; Provisional


Pssm-ID: 237632 [Multi-domain]  Cd Length: 218  Bit Score: 72.14  E-value: 1.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  48 ELKYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAhksavevDKESALTKG-LELTMEKLH 126
Cdd:PRK14164   83 EAQLAERTEDLQRVTAEYANYRRRTERERQAIIETAKAGVATDLLPILDDLDLA-------EQHGDLNEGpLKAFSDKLT 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1152435476 127 EVLARHGIE--GIEClEEFDPNFHNAIMQVKS-EEKENGKivqVLQQGYKYKGRVLRPAMVSIA 187
Cdd:PRK14164  156 NVLAGLKVEkfGEEG-DAFDPEIHEAVQDLSSgDEKVLGT---VLRKGYRMGDRVLRTAMVIIA 215
PRK14142 PRK14142
heat shock protein GrpE; Provisional
 50-186 1.99e-11

heat shock protein GrpE; Provisional


Pssm-ID: 237623  Cd Length: 223  Bit Score: 60.40  E-value: 1.99e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  50 KYKEMHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHK---------SAVEVDKESALTkGLEL 120
Cdd:PRK14142   48 KVAELTADLQRVQADFANYRKRALRDQQAAADRAKASVVSQLLGVLDDLERARKhgdlesgplKSVADKLDSALT-GLGL 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1152435476 121 TMeklhevlarHGIEGieclEEFDPNFHNAImQVKSEEKENGKIV--QVLQQGYKYKGRVLRPAMVSI 186
Cdd:PRK14142  127 VA---------FGAEG----EDFDPVLHEAV-QHEGDGGQGSKPVigTVMRQGYQLGEQVLRHALVGV 180
PRK14146 PRK14146
heat shock protein GrpE; Provisional
 31-188 6.14e-09

heat shock protein GrpE; Provisional


Pssm-ID: 172635 [Multi-domain]  Cd Length: 215  Bit Score: 53.58  E-value: 6.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  31 EEKQEAHEKEGEIREDFELKYKE---MHEKYLRVHADFENVKKRLERDKSMALEYAYEKIALDLLPVIDALLGAHKSAVE 107
Cdd:PRK14146   47 EQAVEGAETETSLQKELDNAKKEiesLKDSWARERAEFQNFKRRSAQEFVSIRKEAVKSLVSGFLNPIDNLERVGATQNQ 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 108 VDKESALTKGLELTMEKLHEVLARHGIEGIECL-EEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYK----GRVLRPA 182
Cdd:PRK14146  127 SEELKPFVEGVKMILKEFYSVLEKSNVIRFDPKgEPFDPMSMEALSSEEGDQYSEETVIDVYQAGYYYKenedKFTLRPA 206


                  ....*.
gi 1152435476 183 MVSIAK 188
Cdd:PRK14146  207 RVRIGK 212
PRK14157 PRK14157
heat shock protein GrpE; Provisional
 31-187 7.66e-05

heat shock protein GrpE; Provisional


Pssm-ID: 184543 [Multi-domain]  Cd Length: 227  Bit Score: 41.87  E-value: 7.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476  31 EEKQEAHEKEGEIREDFEL------KYKEMHEKYL----RVHADFENVKKRLERDKSMALEYAyekialdLLPVIDALLG 100
Cdd:PRK14157   63 GEAKAAAEKTGEAQSDSDDtltplgQAKKEAAEYLealqRERAEFINYRNRTQKEQDRFRQHG-------IIDVLTALLP 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1152435476 101 AHKSAVEVDKESALTKGLELTMEKLHEVLARHGIEGI-ECLEEFDPNFHNAIMQVKSEEKENGKIVQVLQQGYKYKGRVL 179
Cdd:PRK14157  136 ALDDIDRIREHSEMDDSFKAVAAKIDKAFEKFGVEKFgEKGEDFDPTKHDAILHKPDPDAEKETVDTVVEAGYRIGDRVI 215


                  ....*...
gi 1152435476 180 RPAMVSIA 187
Cdd:PRK14157  216 RAARVVVA 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH