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Conserved domains on  [gi|1153889769|ref|WP_078408191|]
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IS200/IS605 family accessory protein TnpB-related protein, partial [Bacillus anthracis]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
tspaseT_teng_C TIGR01766
transposase, IS605 OrfB family, central region; This model represents a region of a sequence ...
165-245 1.16e-17

transposase, IS605 OrfB family, central region; This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions]


:

Pssm-ID: 273793 [Multi-domain]  Cd Length: 82  Bit Score: 76.60  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 165 STNKRTTVIGQIVQQIKKWLIENNvGGIVLEDLK-FQQSHD-TDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPA 242
Cdd:TIGR01766   1 ERNKVEDFLHKIVKQIVEYAKENN-GTIVLEDLKnIREMVDkKSKYLRRKLHQWSFRKLISKIKYKAEEYGIEVIEVNPA 79

                  ...
gi 1153889769 243 HTS 245
Cdd:TIGR01766  80 YTS 82
guided_TnpB NF040570
RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB ...
43-255 1.14e-12

RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.


:

Pssm-ID: 468544 [Multi-domain]  Cd Length: 384  Bit Score: 68.34  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769  43 GRTNGKTKSPRIKVPIIIPYRFYHEITNVVMGEQIGVNPKGKPIIdhqkysveiIRKQNDFYVNITFDETEIgrvlDFKE 122
Cdd:NF040570  121 KKRNRKKKNGRLKLPKLGGVKLRLSRILPILLDGKGGKIKSVTIS---------KPKKGKYYVSISVEVEVP----EPPP 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 123 TPQSDLIAGIDVNPDRIAV--------------------------------SLCTKQGNFKGSKIFYLHNLDTFSTNKRT 170
Cdd:NF040570  188 KEVTGKVVGIDLGLKNFATlsdggekienprflrkkekrlrrlqrklsrklQRKGKGSSNRKKARKKVARLHRKIANQRK 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 171 TVIGQIVQQIKKWLIENNVGGIVLEDLKFQQSHdTDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPAHTSVIGKL 250
Cdd:NF040570  268 DFLHKLSKRLVKEADANNVVVEDLEVKGMVKNK-KKKKLAKSIHDWAFGQLRRMLEYKAEWYGIKVVKVDPAYTSSQCCS 346

                  ....*
gi 1153889769 251 KYCKK 255
Cdd:NF040570  347 CGGHR 351
 
Name Accession Description Interval E-value
tspaseT_teng_C TIGR01766
transposase, IS605 OrfB family, central region; This model represents a region of a sequence ...
165-245 1.16e-17

transposase, IS605 OrfB family, central region; This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions]


Pssm-ID: 273793 [Multi-domain]  Cd Length: 82  Bit Score: 76.60  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 165 STNKRTTVIGQIVQQIKKWLIENNvGGIVLEDLK-FQQSHD-TDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPA 242
Cdd:TIGR01766   1 ERNKVEDFLHKIVKQIVEYAKENN-GTIVLEDLKnIREMVDkKSKYLRRKLHQWSFRKLISKIKYKAEEYGIEVIEVNPA 79

                  ...
gi 1153889769 243 HTS 245
Cdd:TIGR01766  80 YTS 82
guided_TnpB NF040570
RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB ...
43-255 1.14e-12

RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.


Pssm-ID: 468544 [Multi-domain]  Cd Length: 384  Bit Score: 68.34  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769  43 GRTNGKTKSPRIKVPIIIPYRFYHEITNVVMGEQIGVNPKGKPIIdhqkysveiIRKQNDFYVNITFDETEIgrvlDFKE 122
Cdd:NF040570  121 KKRNRKKKNGRLKLPKLGGVKLRLSRILPILLDGKGGKIKSVTIS---------KPKKGKYYVSISVEVEVP----EPPP 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 123 TPQSDLIAGIDVNPDRIAV--------------------------------SLCTKQGNFKGSKIFYLHNLDTFSTNKRT 170
Cdd:NF040570  188 KEVTGKVVGIDLGLKNFATlsdggekienprflrkkekrlrrlqrklsrklQRKGKGSSNRKKARKKVARLHRKIANQRK 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 171 TVIGQIVQQIKKWLIENNVGGIVLEDLKFQQSHdTDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPAHTSVIGKL 250
Cdd:NF040570  268 DFLHKLSKRLVKEADANNVVVEDLEVKGMVKNK-KKKKLAKSIHDWAFGQLRRMLEYKAEWYGIKVVKVDPAYTSSQCCS 346

                  ....*
gi 1153889769 251 KYCKK 255
Cdd:NF040570  347 CGGHR 351
 
Name Accession Description Interval E-value
tspaseT_teng_C TIGR01766
transposase, IS605 OrfB family, central region; This model represents a region of a sequence ...
165-245 1.16e-17

transposase, IS605 OrfB family, central region; This model represents a region of a sequence similarity between a family of putative transposases of Thermoanaerobacter tengcongensis, smaller related proteins from Bacillus anthracis, putative transposes described by pfam01385, and other proteins. [Mobile and extrachromosomal element functions, Transposon functions]


Pssm-ID: 273793 [Multi-domain]  Cd Length: 82  Bit Score: 76.60  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 165 STNKRTTVIGQIVQQIKKWLIENNvGGIVLEDLK-FQQSHD-TDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPA 242
Cdd:TIGR01766   1 ERNKVEDFLHKIVKQIVEYAKENN-GTIVLEDLKnIREMVDkKSKYLRRKLHQWSFRKLISKIKYKAEEYGIEVIEVNPA 79

                  ...
gi 1153889769 243 HTS 245
Cdd:TIGR01766  80 YTS 82
guided_TnpB NF040570
RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB ...
43-255 1.14e-12

RNA-guided endonuclease TnpB family protein; This family includes RNA-guided endonuclease TnpB from IS200/IS605 family elements (NF038281) and IS607 family elements (NF038280), but also many additional proteins. It exhibits homolog to or actually includes some CRISPR-associated (Cas) proteins such as the type V CRISPR-associated protein C2c8. For a long time, TnpB proteins were described as accessory proteins in IS (insertion sequence) elements, present as one of just one or two proteins encoded in the element but not necessary for transposition. The programmable RNA-guided endonuclease TnpB proteins may provide a CRISPR-like, widespread form of phage defense by RNA-guided DNA degradation.


Pssm-ID: 468544 [Multi-domain]  Cd Length: 384  Bit Score: 68.34  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769  43 GRTNGKTKSPRIKVPIIIPYRFYHEITNVVMGEQIGVNPKGKPIIdhqkysveiIRKQNDFYVNITFDETEIgrvlDFKE 122
Cdd:NF040570  121 KKRNRKKKNGRLKLPKLGGVKLRLSRILPILLDGKGGKIKSVTIS---------KPKKGKYYVSISVEVEVP----EPPP 187
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 123 TPQSDLIAGIDVNPDRIAV--------------------------------SLCTKQGNFKGSKIFYLHNLDTFSTNKRT 170
Cdd:NF040570  188 KEVTGKVVGIDLGLKNFATlsdggekienprflrkkekrlrrlqrklsrklQRKGKGSSNRKKARKKVARLHRKIANQRK 267
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1153889769 171 TVIGQIVQQIKKWLIENNVGGIVLEDLKFQQSHdTDKYSNRKFHQFTYKKMLDSLIRMALRNGFSVKTVNPAHTSVIGKL 250
Cdd:NF040570  268 DFLHKLSKRLVKEADANNVVVEDLEVKGMVKNK-KKKKLAKSIHDWAFGQLRRMLEYKAEWYGIKVVKVDPAYTSSQCCS 346

                  ....*
gi 1153889769 251 KYCKK 255
Cdd:NF040570  347 CGGHR 351
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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