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Conserved domains on  [gi|1154114169|ref|WP_078489772|]
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GntR family transcriptional regulator [Streptomyces sp. SPB78]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-236 2.19e-53

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 172.74  E-value: 2.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   4 AAAPKRERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvPAKTMRELLP 81
Cdd:COG2188     2 SPVPLYLQIADALRERIESGelPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA-EPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  82 NGRGLAMPLTRG-TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAG 160
Cdd:COG2188    81 LTSFTEELRARGrEPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 161 -LHAHLEDSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYRVVSRLSP 236
Cdd:COG2188   161 sLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-236 2.19e-53

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 172.74  E-value: 2.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   4 AAAPKRERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvPAKTMRELLP 81
Cdd:COG2188     2 SPVPLYLQIADALRERIESGelPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA-EPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  82 NGRGLAMPLTRG-TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAG 160
Cdd:COG2188    81 LTSFTEELRARGrEPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 161 -LHAHLEDSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYRVVSRLSP 236
Cdd:COG2188   161 sLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-229 7.35e-29

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 106.61  E-value: 7.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   94 TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAGLHAHLED---SHR 170
Cdd:smart00866   5 KPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEErlgLKI 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1154114169  171 SEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYR 229
Cdd:smart00866  85 VRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-229 4.41e-28

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 104.60  E-value: 4.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  94 TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTH-TPQAGLHAHLEDSHRSE 172
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdLEEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 173 GYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYR 229
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 7-236 9.39e-20

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 85.06  E-value: 9.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   7 PKRERVRQHILSLVR-GR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvPAKTMRELLpNGR 84
Cdd:TIGR02018   1 PLYQRIKQDILERIRsGEwPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVA-EPKAQSALL-EIR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  85 GLAMP-LTRGTV-SGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPD-LPTHTPQAGL 161
Cdd:TIGR02018  79 NIADEiVARGHRyRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDyLKQDFTQTTP 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154114169 162 HAHLedSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTdEQGRPVEYVRSVYRGDRYRVVSRLSP 236
Cdd:TIGR02018 159 GAYL--SQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTW-SGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK11402 PRK11402
transcriptional regulator PhoB;
3-227 3.68e-19

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 83.73  E-value: 3.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   3 GAAAPKRERVRQHILS-LVRG-RAAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVPaKTMRELL 80
Cdd:PRK11402    5 YSHQLLYATVRQRLLDdIAQGvYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ-KVENALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  81 P-NGRGLAMPLTRGTVSGQVLgcSVGRAEGIP-GRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQ 158
Cdd:PRK11402   84 TvSGFTDFGVSQGKATKEKVI--EQERVSAAPfCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 159 -AGLHAHLEDSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDR 227
Cdd:PRK11402  162 gSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-70 5.88e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 67.47  E-value: 5.88e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1154114169   7 PKRERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVA 70
Cdd:cd07377     1 PLYEQIADQLREAILSGelKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
4-236 2.19e-53

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 172.74  E-value: 2.19e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   4 AAAPKRERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvPAKTMRELLP 81
Cdd:COG2188     2 SPVPLYLQIADALRERIESGelPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVA-EPKIEYPLSR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  82 NGRGLAMPLTRG-TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAG 160
Cdd:COG2188    81 LTSFTEELRARGrEPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 161 -LHAHLEDSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYRVVSRLSP 236
Cdd:COG2188   161 sLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRR 237
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-229 7.35e-29

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 106.61  E-value: 7.35e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   94 TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAGLHAHLED---SHR 170
Cdd:smart00866   5 KPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEErlgLKI 84

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1154114169  171 SEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYR 229
Cdd:smart00866  85 VRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-229 4.41e-28

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 104.60  E-value: 4.41e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  94 TVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTH-TPQAGLHAHLEDSHRSE 172
Cdd:pfam07702   5 EPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEdLEEGSLYDYLEERYGLP 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 173 GYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDRYR 229
Cdd:pfam07702  85 ITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 7-236 9.39e-20

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 85.06  E-value: 9.39e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   7 PKRERVRQHILSLVR-GR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvPAKTMRELLpNGR 84
Cdd:TIGR02018   1 PLYQRIKQDILERIRsGEwPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVA-EPKAQSALL-EIR 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  85 GLAMP-LTRGTV-SGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPD-LPTHTPQAGL 161
Cdd:TIGR02018  79 NIADEiVARGHRyRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDyLKQDFTQTTP 158

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154114169 162 HAHLedSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTdEQGRPVEYVRSVYRGDRYRVVSRLSP 236
Cdd:TIGR02018 159 GAYL--SQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTW-SGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK11402 PRK11402
transcriptional regulator PhoB;
3-227 3.68e-19

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 83.73  E-value: 3.68e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   3 GAAAPKRERVRQHILS-LVRG-RAAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVPaKTMRELL 80
Cdd:PRK11402    5 YSHQLLYATVRQRLLDdIAQGvYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQ-KVENALL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  81 P-NGRGLAMPLTRGTVSGQVLgcSVGRAEGIP-GRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQ 158
Cdd:PRK11402   84 TvSGFTDFGVSQGKATKEKVI--EQERVSAAPfCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 159 -AGLHAHLEDSHRSEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDR 227
Cdd:PRK11402  162 gSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANR 231
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 24-227 6.03e-19

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 82.91  E-value: 6.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  24 AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVpaktmrellpngRGLAMPLTRGTVSGQVLGCS 103
Cdd:TIGR02325  27 RAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAA------------RRIDYPLSARTRFSQNLADQ 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 104 VGRAEGIP------------GRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAG-LHAHLEDSHR 170
Cdd:TIGR02325  95 GREPTGELllsdlepasaelADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAASGsITDALREQGV 174

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169 171 SEGYEAVQSTEPVLVDETEAAVLEVPVLSPALLIERVTTDEQGRPVEYVRSVYRGDR 227
Cdd:TIGR02325 175 ADYRRSSTRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 7-70 5.88e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 67.47  E-value: 5.88e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1154114169   7 PKRERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVA 70
Cdd:cd07377     1 PLYEQIADQLREAILSGelKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 10-69 3.70e-12

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 59.94  E-value: 3.70e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154114169  10 ERVRQHILSlvrGR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFV 69
Cdd:pfam00392   7 ARLREDILS---GRlRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
10-69 8.92e-12

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 58.74  E-value: 8.92e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154114169   10 ERVRQHIlslVRGR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFV 69
Cdd:smart00345   3 ERLREDI---VSGElRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK14999 PRK14999
histidine utilization repressor; Provisional
 3-235 2.74e-11

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 61.87  E-value: 2.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   3 GAAAPKRERVRQHILSLVRGRA--AGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVPAKtmRELL 80
Cdd:PRK14999    8 SAPAPFYETVKQDICKKIAGGVwqPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKG--QSAL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  81 PNGRGLAMPLT--RGTVSGQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPD-LPTHTP 157
Cdd:PRK14999   86 FEVRSIAEEIAarRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDyLTQDYR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 158 QAGLHAHLED-SHRSEG---YEAVQSTepvlvdETEAAVLEVPVLSPALLIERvTTDEQGRPVEYVRSVYRGDRYRVVSR 233
Cdd:PRK14999  166 QTTPHAYLSRiAPLTEGehiVEAVRAT------AQECAWLTIKEHEPCLLIRR-TTWSASRIVSHARLLFPGSRYRLQGR 238


                  ..
gi 1154114169 234 LS 235
Cdd:PRK14999  239 FI 240
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
10-70 3.78e-11

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 61.10  E-value: 3.78e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154114169  10 ERVRQHILSlvRGRAAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVA 70
Cdd:COG2186    14 EQLRELILS--GELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVR 72
PRK09764 PRK09764
GntR family transcriptional regulator;
10-229 2.30e-10

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 59.07  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  10 ERVRQHIlslVRGR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAvpAKTMRELLPNGRGLAM 88
Cdd:PRK09764   12 DRIREQI---ARGElKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVK--EERVNYDIFQLTSFDE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  89 PLTRGTVS--GQVLGCSVGRAEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPRELVPDLPTHTPQAGLHAHLE 166
Cdd:PRK09764   87 KLSDRHVDthSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKYHFIE 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 167 DSH-----RSEgyeavQSTEPVLVDETEAAVLEVPVLSPalLIERVTTD--EQGRPVEYVRSVYRGDRYR 229
Cdd:PRK09764  167 EVKkmvidRSE-----QEIIPLMPTEEMSRLLNISQTKP--ILEKVSRGylVDGRVFEYSRNAFNTDDYK 229
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 4-70 6.35e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 59.07  E-value: 6.35e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154114169   4 AAAPKRERVRQHILSLVR-GR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVA 70
Cdd:COG1167     9 SSGPLYLQLADALREAILsGRlPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
9-78 1.33e-09

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 54.41  E-value: 1.33e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154114169   9 RERVRQHILSlvrGR-AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVPAKTMRE 78
Cdd:COG1725    16 ADQIKEAIAS---GElKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLE 83
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 26-226 1.22e-07

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 51.31  E-value: 1.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  26 GEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVavpakTMR----ELLPNGRGLAMPLTRGTVSGQVLG 101
Cdd:PRK10079   32 GDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLV-----LMRpydyPLNAQARFSQNLLDQGSHPTSEKL 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169 102 CSVGR-AEGIPGRRLGAAPQDLLVHVTRLWRAEGRPLSLEHLYIPR-ELVPDLPTHTpQAGLHAHLEDSHRSEGYEAVQS 179
Cdd:PRK10079  107 LSVLRpASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADlTWWPTLQRFD-SGSLHDFLREQLGIALRRSQTR 185

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1154114169 180 TEPVLVDETEAAVLEVPVLSPALLIERVTT-DEQGRPVEYVRSVYRGD 226
Cdd:PRK10079  186 ISARRAQAKESQLLEIPNMSPLLCVRTLNHrDGESSPAEYSVSLTRAD 233
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 10-69 2.82e-07

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 50.15  E-value: 2.82e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1154114169  10 ERVRQHILSLV--RGRAAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFV 69
Cdd:PRK10421    5 DEVADRVRALIeeKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
2-80 1.45e-06

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 47.99  E-value: 1.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169   2 AGAAAPKRERVRQHILS-LVRGR-AAGEAIpSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVAVP-AKTMRE 78
Cdd:COG1802     6 PLRRESLAEQVYEALREaILSGElPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLsPEEIRE 84


                  ..
gi 1154114169  79 LL 80
Cdd:COG1802    85 LY 86
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
24-69 1.58e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 48.09  E-value: 1.58e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1154114169  24 AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFV 69
Cdd:PRK09464   29 RPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFV 74
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 25-70 1.74e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 47.84  E-value: 1.74e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1154114169  25 AGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVA 70
Cdd:PRK09990   27 VGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA 72
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 10-64 8.80e-05

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 42.70  E-value: 8.80e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1154114169  10 ERVRQHILSLVRGR--AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHG 64
Cdd:PRK03837   16 EEVEERLEQMIRSGefGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 10-100 3.10e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 41.57  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154114169  10 ERVRQHILSlvRGRAAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFVavpaktmrellpngRGLAMP 89
Cdd:PRK15481   12 DSIRQLIQA--GRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVI--------------RGSPSP 75

                          90
                  ....*....|..
gi 1154114169  90 LTR-GTVSGQVL 100
Cdd:PRK15481   76 VALeGGDPGTPL 87
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 8-64 8.25e-04

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 39.73  E-value: 8.25e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1154114169   8 KRERvRQHILSLVR--GRAageaipSERELSALLGVSRPTLRAAADELVASGLLRREHG 64
Cdd:COG1349     3 AEER-RQKILELLRerGRV------SVEELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
24-65 8.33e-04

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 39.85  E-value: 8.33e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1154114169  24 AAGEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGR 65
Cdd:PRK04984   26 PPGSILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGK 67
PRK10225 PRK10225
Uxu operon transcriptional regulator;
26-69 3.63e-03

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 38.08  E-value: 3.63e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1154114169  26 GEAIPSERELSALLGVSRPTLRAAADELVASGLLRREHGRGMFV 69
Cdd:PRK10225   30 GERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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