|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
29-511 |
5.35e-83 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 262.49 E-value: 5.35e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 29 LMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSA 108
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIAR----DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 109 LAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN 188
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 189 VPIVILALGLMvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfekrs 268
Cdd:cd17321 157 VPIGLVALLLA--------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 269 dhpsldvtyfknKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRA 348
Cdd:cd17321 168 ------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 349 TTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAV 428
Cdd:cd17321 236 VLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVAL 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 429 LGSVLSTAYRNSIEgklgmlpanlrdtagesieatlgvaaklGPRGQALVDPANDAFLHAMHVTALCGAVVALLGAVVTA 508
Cdd:cd17321 316 LGALLTAGLSANLG----------------------------DSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALLAL 367
|
...
gi 1154253362 509 VFL 511
Cdd:cd17321 368 LLP 370
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
21-517 |
5.73e-79 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 256.19 E-value: 5.73e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 21 RRWAILGVLMLSLLIVVLDNSILNVAIKTISTPaptgLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGL 100
Cdd:PRK14995 3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMT----LGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 101 VVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPK-AIGIWAGGVGLAIAIGPITGGLLLDHF 179
Cdd:PRK14995 79 TLFGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNmALGVWAAVGSGGAAFGPLVGGILLEHF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 180 WWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPVGVVLSVVGLVLLVYGIIKGgeLADFTDPKVLA-TIIAGVVVL 258
Cdd:PRK14995 159 YWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTA--LKGFLSLWVTSlTLLTGALLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 259 AAFILFEKRSDHPSLDVTYFKNKVFSAA--MAAIALVffALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPR 336
Cdd:PRK14995 237 GLFIRTQLAASRPMIDMRLFTHRIILSGvvMAMTAMI--TLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 337 ARLVVDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNT 416
Cdd:PRK14995 315 AGILVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETM 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 417 FRQVGGALGIAVLGSVLSTAYRNSIEGKLGmLPANLRDTAGESIEATLGVAAKLGP-RGQALVDPANDAFLHAMHVTALC 495
Cdd:PRK14995 395 AYELGAGLGIAIFGLLLSRSYSASIRLPAG-LPAQLIEKASSSIGEAVQLANSLPPtLGQALLDAAKQAFIWSHSVVLSS 473
|
490 500
....*....|....*....|..
gi 1154253362 496 GAVVALLGAVVTAVFLPGRPQQ 517
Cdd:PRK14995 474 AGSMLLLLAVGVWFSLAKAQRR 495
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
29-435 |
5.00e-70 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 229.00 E-value: 5.00e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 29 LMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSA 108
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMG----DLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 109 LAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN 188
Cdd:cd17503 77 LCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 189 VPIVILALGLMvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfekrs 268
Cdd:cd17503 157 LPIGILALLLA--------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 269 dhPSLDVTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRA 348
Cdd:cd17503 168 --PLLDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRL 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 349 TTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAV 428
Cdd:cd17503 246 LLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTAL 325
|
....*..
gi 1154253362 429 LGSVLST 435
Cdd:cd17503 326 LATLLTN 332
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
26-437 |
4.91e-68 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 227.26 E-value: 4.91e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 26 LGVLMLSLLIVVLDNSILNVAIKTISTPaptgLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGI 105
Cdd:TIGR00711 4 TIVLMLGTFMAVLDSTIVNVAIPTIAGD----LGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 106 GSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVF 185
Cdd:TIGR00711 80 GSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 186 LINVPIVILALGLMVWLVPDSRDPRPGRLDPVGVVLSVVGLVLLVYGIIKGGELADFTDPKVLATIIAGVVVLAAFILFE 265
Cdd:TIGR00711 160 LINVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILSITGLVAIIAFVVWE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 266 KRSDHPSLDVTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFG 345
Cdd:TIGR00711 240 LTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKID 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 346 YRATTTAGLALLAGMLGAFAA-FDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGAL 424
Cdd:TIGR00711 320 PRKLVTIGLILYAVGFYWRAFtFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSI 399
|
410
....*....|...
gi 1154253362 425 GIAVLGSVLSTAY 437
Cdd:TIGR00711 400 GTALITTILTNRT 412
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-424 |
6.74e-48 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 169.77 E-value: 6.74e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 17 AVHRRRWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVL 96
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAA----DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 97 LGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLL 176
Cdd:COG2814 79 LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 177 DHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPVGVvlsvvglvllvygiikggeladftdpkvlatiiagvv 256
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 257 vlaafilfekrsdhpsldvTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPR 336
Cdd:COG2814 202 -------------------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 337 ARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNT 416
Cdd:COG2814 263 AGRLADRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNS 339
|
....*...
gi 1154253362 417 FRQVGGAL 424
Cdd:COG2814 340 AFFLGGPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
29-428 |
1.29e-43 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 157.73 E-value: 1.29e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 29 LMLSLLIVVLDNSILNVAIKTISTPaptgLGAtQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSA 108
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAE----FGG-LSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 109 LAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN 188
Cdd:cd17502 76 LCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 189 VPIVILALGLMvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfekrs 268
Cdd:cd17502 156 LPIGGLALALL--------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 269 dhpsldvtyfknKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFG-YR 347
Cdd:cd17502 167 ------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYK 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 348 ATTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIA 427
Cdd:cd17502 235 PLIVIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
|
.
gi 1154253362 428 V 428
Cdd:cd17502 315 I 315
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-435 |
6.73e-38 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 142.70 E-value: 6.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 20 RRRWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGG 99
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQA----DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 100 LVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHF 179
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 180 WWGSVFLINVPIVILALGLMVWLVpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvla 259
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLRFWLL-------------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 260 afilfekrsdhpsldvtyfknkvfsaaMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARL 339
Cdd:COG2271 186 ---------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 340 VVDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLeVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQ 419
Cdd:COG2271 239 LSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAI-ALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF 317
|
410
....*....|....*.
gi 1154253362 420 VGGALGIAVLGSVLST 435
Cdd:COG2271 318 LGGALGPLLVGYLLDA 333
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
29-425 |
1.19e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 133.31 E-value: 1.19e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 29 LMLSLLIVVLDNSILNVAIktiSTPAPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSA 108
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAL---PLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 109 LAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN 188
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 189 VPIVILALGLMVWLVPDSRDPRPGRldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilFEKRS 268
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKP--------------------------------------------------AEEAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 269 DHPSLDVTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYtQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRA 348
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154253362 349 TTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALG 425
Cdd:pfam07690 267 RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
14-306 |
3.03e-34 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 131.09 E-value: 3.03e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 14 IPEAVHRRRWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRK 93
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAA----DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 94 KVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGG 173
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 174 LLLDHFWWGSVFLINVPIVILALGLMVWLvpdsRDPRPGRLDPVGVVLSVVGLVLLVYGIIKGGELADFTDPKVLATIIA 253
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLLALVLRLRL----PESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLA 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1154253362 254 GVVVLAAFILFEKRSDHPSLDVTYFKNKVFSAAMAAIALVFFALMGVTFFSVF 306
Cdd:COG0477 236 GAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLL 288
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-425 |
4.36e-33 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 129.61 E-value: 4.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 26 LGVLMLSLLIVVLDNSILNVAIKTISTPaptgLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGI 105
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEA----LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 106 GSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVF 185
Cdd:cd17474 77 GGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 186 LINVPIVILALGLMVWLVPDSRDPRPGRldpvgvvlsvvglvllvygiikggeladftDPKVLATIIAgvvvlaafilfe 265
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKAKSSS------------------------------ATKLRDLKKA------------ 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 266 krsdhpsldvtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPR-ARLVVDRF 344
Cdd:cd17474 195 ------------LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFvGRLLKKRF 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 345 GYRATTTAGLALLAGMLGAFAAFDAdtpIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGAL 424
Cdd:cd17474 263 GARRILVIGLLLYALSLLLLGFVPS---LALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAV 339
|
.
gi 1154253362 425 G 425
Cdd:cd17474 340 G 340
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-437 |
1.35e-31 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.38 E-value: 1.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:cd17325 26 LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 138 LAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPV 217
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 218 gvvlsvvglvllvyGIIKGGELADFTDPKVLATIIAGVVVLAAFILFEkrsdhpsldvtyfknkvfsaamaaialvffal 297
Cdd:cd17325 186 --------------ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALE-------------------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 298 mgvTFFSVfYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFDAdtpIWLLE 377
Cdd:cd17325 220 ---PFLPL-YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS---FWLLL 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 378 VVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGiAVLGSVLSTAY 437
Cdd:cd17325 293 LLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG-PLLGGFLYDAF 351
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
28-435 |
8.57e-31 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 123.45 E-value: 8.57e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 28 VLMLSLLIVV--LDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGI 105
Cdd:cd17320 1 LLLLALLVALgpLAIDMYLPALPAIAR----DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 106 GSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVF 185
Cdd:cd17320 77 ASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 186 LINVPIVILALGLMVWLVPDSRDPRPGRLDPvgvvlsvvGLVLLVYGIIkggeladFTDPKVLATIIAGVVVLAAFilfe 265
Cdd:cd17320 157 VFLALLGLLLLLLVLLFLPETLPEEKRKPLL--------SSLLRAYKRV-------LKNRRFLGYALALGLSFAGL---- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 266 krsdhpsldvtyfknkvfsaamaaiaLVFFALMGVTFFSVFytqsvrGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFG 345
Cdd:cd17320 218 --------------------------FAYLAAAPFIYIEQL------GLSPAQFGLLFALNAIALILGSLLNGRLVRRFG 265
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 346 YRATTTAGLALL--AGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREkAGSASALSNTFRQVGGA 423
Cdd:cd17320 266 PRRLLRLGLLLLlaAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV-AGTASALLGFLQFLIGA 344
|
410
....*....|..
gi 1154253362 424 LGIAVLGSVLST 435
Cdd:cd17320 345 LAGALVGLLPNG 356
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-435 |
3.42e-30 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 121.53 E-value: 3.42e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 29 LMLSLLIVVLDNSILNVAIKTIstpaPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSA 108
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTI----QREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 109 LAAESGSPGQLIAFRALMALGAAfVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN 188
Cdd:cd17504 77 LAAFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 189 VPIVILALGLMvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfekrs 268
Cdd:cd17504 156 APVAVLLAALV--------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 269 dhPSLDVTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGY----SPLQSGLLMIPLAAAQMIFAPRARLVVDRF 344
Cdd:cd17504 167 --PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTgfglGITEAGLLLLPGALVMLIAGPLAGRLIARV 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 345 GYRATTTAGLALLAGMLGAFAAFDADtpIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGAL 424
Cdd:cd17504 245 GPRRVLLIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAI 322
|
410
....*....|.
gi 1154253362 425 GIAVLGSVLST 435
Cdd:cd17504 323 GPAIAGAILTT 333
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
38-435 |
2.81e-25 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 108.67 E-value: 2.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 38 LDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPG 117
Cdd:PRK10504 24 LDTTIVNTALPSMAQ----SLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 118 QLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGI--WAGGVGlaIAIGPITGGLLLDHFWWGSVFLINVPIVILA 195
Cdd:PRK10504 100 ELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFvtLPGQVG--PLLGPALGGLLVEYASWHWIFLINIPVGIIG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 196 LGLMVWLVPDSRDPrPGRLDPVGVVLSVVGLVLLVYGiIKGGELADFTDPKVLATIIAGVVVLAAFILFEKRSDHPSLDV 275
Cdd:PRK10504 178 AIATLMLMPNYTMQ-TRRFDLSGFLLLAVGMATLTLA-LDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 276 TYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLA 355
Cdd:PRK10504 256 KLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVLVATTL 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 356 LLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLST 435
Cdd:PRK10504 336 GLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVTIAGLLLGL 415
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
67-435 |
4.74e-25 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 108.48 E-value: 4.74e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 67 WAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRAL--MALGAAFVMPAtlaVLMNV 144
Cdd:cd06179 36 WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALigIGAGTQGLGAA---VASEL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 145 FEREEQPKAIGIWAGGVGLAIAIGPITGGLLL--DHFWWGSVFLINVPIVILAL-GLMVW--------LVPDSRDPRPGR 213
Cdd:cd06179 113 VPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINAIFNALALiLLFFFyhppprpqLHGSSTRQKLKR 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 214 LDPVGVVLSVVGLVLLVYGIIKGGELADFTDPKVLATIIAGVVVLAAFILFE--KRSDHPSLDVTYFKNKVFSAAMAAIa 291
Cdd:cd06179 193 LDWVGLFLLIAGLVLFLLGLSWGGNPYPWSSAHVIAPLVIGGVLLIAFGLYEwkGTKDGLLPPRLLFRGRNFALILIVA- 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 292 lvFFALMGVTFFSVFYTQSVRGY---SPLQSGLLMIPLAAAQMIFAPRARLVVDRFGY-RATTTAGLALLAGMLGAFAAF 367
Cdd:cd06179 272 --FVEGMIFYSLNIFWPQQISLLfttDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHiKWQLVAGFVLFTAFLALLALI 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154253362 368 DADTPIwlLEVVF-FLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLST 435
Cdd:cd06179 350 TPDNKA--LAIAFsVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSILSN 416
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
58-434 |
2.45e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 101.47 E-value: 2.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 138 LAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPv 217
Cdd:cd17324 109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGL- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 218 gvvlsvvglvllvygiiKGGELADFTDPKVLATIIAGVVVLAAFILFekrsdhpsldvtyfknkvfsaamaaialvffal 297
Cdd:cd17324 188 -----------------LSSLLLLLRNPRLRLAYLITFLLFGGFFAL--------------------------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 298 mgVTFFSVFYTQSVRGYSPLQSGLLMIpLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLLE 377
Cdd:cd17324 218 --YTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG---PSPLLLL 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1154253362 378 VVFFLMGAGMAHIMTPTSVVIMQALPrEKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:cd17324 292 VGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLD 347
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-435 |
6.20e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 100.73 E-value: 6.20e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 20 RRRWAILGVLMLSLLIVVLDNSILNVAIKTIstpaPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGG 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL----AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 100 LVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHF 179
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 180 WWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvla 259
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAA---------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 260 afilfEKRSDHPSLDVtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARL 339
Cdd:COG2223 191 -----AKASLRDQLEA--LRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGW 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 340 VVDRFGYRATTTAGLALLAGMLGAFAAFdaDTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQ 419
Cdd:COG2223 264 LSDRIGGRRVLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGG 341
|
410
....*....|....*.
gi 1154253362 420 VGGALGIAVLGSVLST 435
Cdd:COG2223 342 LGGFLGPLLFGALLDA 357
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-437 |
2.11e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 2.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 33 LLIVVLDNSILNVAIKTISTPAPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAE 112
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 113 SGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWG--SVFLINVP 190
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 191 IVILALGLMVWLVPDSRDPRPgrldpvgvvlsvvglvllvygiiKGGELADFTDPKVLATIIagvvvlaafilfekrsdh 270
Cdd:cd06174 161 LALLAAILLLLVVPDPPESAR-----------------------AKNEEASSKSVLKLLKRV------------------ 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 271 psldvtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRaTT 350
Cdd:cd06174 200 -------LKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR-KP 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 351 TAGLALLAGMLGAFAAFDADTPIWLLeVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLG 430
Cdd:cd06174 272 LLLIGLLLMALGLALLLLAPSLLLLL-LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
....*..
gi 1154253362 431 SVLSTAY 437
Cdd:cd06174 351 FLLAATF 357
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
58-434 |
8.93e-20 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 90.78 E-value: 8.93e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:cd17476 28 FGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 138 LAVLMNVFER-EEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINvpivilalglmvwlvpdsrdprpgrldp 216
Cdd:cd17476 108 MALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL---------------------------- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 217 vgvvlsvvglvllvygiikggeladftdpkvlaTIIAGVVVLAAFilfekrsdhpsldvtYFKNKVFSAAMAAIALVFFA 296
Cdd:cd17476 160 ---------------------------------AILAAIVAVAAI---------------FWTSPSFIAVLLAVFLGWAS 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 297 LMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFgyRATTTAGLALLAGMLGA--FAAFDADTPIW 374
Cdd:cd17476 192 FGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARL--PPSYIMAISMVAFLVGPilFATMPVHQTYW 269
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 375 LLEVV-FFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:cd17476 270 AQAFPaMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAGTVET 330
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-435 |
4.77e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 85.70 E-value: 4.77e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 22 RWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLV 101
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMK----DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSML 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 102 VFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWW 181
Cdd:cd17319 77 LWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 182 GSVFLInvpivilalglmvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlaTIIAGVVVLAAF 261
Cdd:cd17319 157 RWAFII--------------------------------------------------------------EGLLGLLLAVLW 174
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 262 ILFEKRsdhpsldvtyfknkvfsaaMAAIALVFFALMGVTFFSVF----YTQSVRGYSPLQSGLLM-IP--LAAAQMIFA 334
Cdd:cd17319 175 WFYLRQ-------------------VWGLALGYFGINYALYGLLTwlptYLKQARGFSLKQVGLLAaIPflAGAIGMILG 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 335 PRARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALS 414
Cdd:cd17319 236 GRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT---TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLI 312
|
410 420
....*....|....*....|.
gi 1154253362 415 NTFRQVGGALGIAVLGSVLST 435
Cdd:cd17319 313 NSGGNLGGFVAPLLIGYLVDA 333
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
83-206 |
2.11e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.85 E-value: 2.11e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 83 AGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVG 162
Cdd:TIGR00880 18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1154253362 163 LAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDS 206
Cdd:TIGR00880 98 LGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
28-441 |
3.50e-17 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 83.59 E-value: 3.50e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 28 VLMLSLLIVVldnSILNVAIKTISTPA-PTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIG 106
Cdd:TIGR00710 7 ALLLGCLSIL---GPLGIDMYLPAFPEiAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 107 SALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFL 186
Cdd:TIGR00710 84 SLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 187 INVPIVILALGLMVWLVPDSRDPRpgrldpvgvvlsvvglvllvygiikggeladftdpkvlATIIAGVVVLAAFILfek 266
Cdd:TIGR00710 164 FLSLAGILLSALIFFILPETLPYE--------------------------------------ARIQISTYFETFLLL--- 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 267 rsdhpsldvtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGY 346
Cdd:TIGR00710 203 -----------LKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 347 RATTTAGLALLA--GMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPrEKAGSASALSNTFRQVGGAL 424
Cdd:TIGR00710 272 KSLLRMGLILFAvsAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFP-HVAGTASALFGTLRLVLGAI 350
|
410
....*....|....*..
gi 1154253362 425 giavLGSVLSTAYRNSI 441
Cdd:TIGR00710 351 ----VGYLVSLIHGNTA 363
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
57-434 |
8.91e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 81.87 E-value: 8.91e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 57 GLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPA 136
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 137 TLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALgLMVWLVPdsrdprpgrldp 216
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLAL-LLVFLVK------------ 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 217 vgvvlsvvglvllvygiikggeladftDPKVLATIIAGVVVLAAFILFEKRsdhpsldvtyfknkVFSAAMAAIaLVFFA 296
Cdd:cd17489 172 ---------------------------DPPPVAAEEAEAGTRAFRRLVEKK--------------VLPPALILF-LASIA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 297 LMGVTFFSVFYTQSvRGYSplQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAfdADTPIWLL 376
Cdd:cd17489 210 YGAISTFLPLYAAE-RGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSF--AGSPWMLL 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 377 eVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:cd17489 285 -LAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE 341
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
28-417 |
1.02e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.77 E-value: 1.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 28 VLMLSLLIVVLDNSILNVAIKTISTPAPtglGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGS 107
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFV---PNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 108 ALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLI 187
Cdd:cd17473 80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 188 NVPIVILAlgLMVWLVPDSRDPRPGRLDPVGVVlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfekr 267
Cdd:cd17473 160 LLALPVLI--LVLLFLPEPARKSKSAASPGAAT----------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 268 sdhpsldVTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYR 347
Cdd:cd17473 191 -------AAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR 263
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 348 ATTTAGLALLAgmlGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTF 417
Cdd:cd17473 264 RLLAIGFALMA---LGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSA 330
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
58-203 |
3.25e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 77.23 E-value: 3.25e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1154253362 138 LAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLV 203
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-436 |
3.82e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 77.40 E-value: 3.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 20 RRRWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptglgatqselEWAINAYTLvfaGLLFTAGLVG------------ 87
Cdd:TIGR00895 13 RYQWRAIILSFLIMLMDGYDLAAMGFAAPAISA-------------EWGLDPVQL---GFLFSAGLIGmafgalffgpla 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 88 DRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAI 167
Cdd:TIGR00895 77 DRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 168 GPITGGLLLDHFWWGSVFLINVPI-VILALGLMVWLvPDSRDprpgrldpvgvvlsvvglvllvYGIIKGGELADFTDPK 246
Cdd:TIGR00895 157 GGFLAGWLIPVFGWRSLFYVGGIApLLLLLLLMRFL-PESID----------------------FLVSKRPETVRRIVNA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 247 VLATIIAGvvvlAAFILFEKRSDHPSLdvTYFKNKVFSAAMAAIALVFFALMGVTFFSVF-------YTQSVRGYSPLQS 319
Cdd:TIGR00895 214 IAPQMQAE----AQSALPEQKSTQGTK--RSVFKALFQGKTARITVLLWLLYFMLLVGVYfltnwlpKLMVELGFSLSLA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 320 GLLMIPLAAAQMIFAPRARLVVDRFGYRatTTAGLALLAGMLGAFAAFDADTP-IWLLEVVFFLMGAGMAHIMTPTSvvi 398
Cdd:TIGR00895 288 ATGGALFNFGGVIGSIIFGWLADRLGPR--VTALLLLLGAVFAVLVGSTLFSPtLLLLLGAIAGFFVNGGQSGLYAL--- 362
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1154253362 399 mqalprekagSASALSNTFRQ--VGGALGIAVLGSVLSTA 436
Cdd:TIGR00895 363 ----------MALFYPTAIRAtgVGWAIGIGRLGAIIGPI 392
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
71-435 |
2.00e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.88 E-value: 2.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 71 AYTLVFAGLLFTAGLVGDRVGRKKVLLG-----GLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVF 145
Cdd:cd06173 42 AFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 146 EREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPVGVvlsvvg 225
Cdd:cd06173 122 PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR------ 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 226 lvllvyGIIKGGELadftdpkvlatiiagvvvlaafilfekrsdhpsldvtYFKNKVFSAAMAAIALVFFALMGVTFFSV 305
Cdd:cd06173 196 ------DLREGLRY-------------------------------------LRRSPLLRLLLLALALFALLGGALTVLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 306 FYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLLEVVFFLMGA 385
Cdd:cd06173 233 LLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGL 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1154253362 386 GMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLST 435
Cdd:cd06173 310 AGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
84-432 |
2.03e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.82 E-value: 2.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 84 GLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATlAVLMNVFEREEQPKAIGIWAGGVGL 163
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSIFSVGGNL 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 164 AIAIGPITGGLLLDHfWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRldpvgvvlsvvglvllvygiikggeladfT 243
Cdd:cd17478 131 GFALGPLIAAALVAL-FGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK-----------------------------A 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 244 DPKVLATIIAGVVVLAAFILFekrsdhpsldvtyfknkvfsAAMAAIALVFFALmgVTFFSVFYTQsvRGYSPLQSGLL- 322
Cdd:cd17478 181 AAKSSARSTLKGVWRALLLLL--------------------IIVFLRSWVLSSL--TTFLPFYLVQ--RGYSLVFAGLLl 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 323 ---MIPLAAAQMIFAPrarlVVDRFGYRATTTAGLALLAGMLGAFAAfdadTPIWLLEVVFFLMGAgMAHIMTPTSVVIM 399
Cdd:cd17478 237 slfLFAGAIGTLIGGP----LSDRFGRRRVIIASLLLAAPFLLLFLL----TPGIWSYILLVLAGF-LLFASFPVTVVLA 307
|
330 340 350
....*....|....*....|....*....|...
gi 1154253362 400 QALPREKAGSASALSNTFRQVGGALGIAVLGSV 432
Cdd:cd17478 308 QELLPGNVGLASGLMMGLSFGLGGIGAPVLGAL 340
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
247-434 |
6.33e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 6.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 247 VLATIIAGVVVLAAFILF-------EKRSDHPSLDVTY---FKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSP 316
Cdd:COG2211 184 LTALIFAVLGLLAFLLTFfgtkerpVPEEEKVSLKESLkalLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 317 LQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLeVVFFLMGAGMAHIMTPTSV 396
Cdd:COG2211 264 ALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLL-VLAALAGIGLGAILVLPWA 342
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1154253362 397 VIMQALP-------REKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:COG2211 343 MLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
72-204 |
2.91e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 65.29 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 72 YTLVFA-GLLFTAGLvGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQ 150
Cdd:cd17323 43 FVLGFGlGPLIWAPL-SELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEER 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 151 PKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVP 204
Cdd:cd17323 122 GKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
58-206 |
3.39e-11 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 64.94 E-value: 3.39e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFA-GLLFTaGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPA 136
Cdd:PRK11102 21 FGVSAGSVQMTLSAYILGFAiGQLFY-GPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVV 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 137 TLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDS 206
Cdd:PRK11102 100 INALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
23-430 |
5.25e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.60 E-value: 5.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 23 WAILGVLMLSLLIVVLDNSILNVAIKtistPAPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVV 102
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFII----PIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 103 FGIGSALAAESGSPGQLIAFRALMALG--AAFVMPATLAVLMNVFEReEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFW 180
Cdd:cd17355 78 LAAGLVLLALATSLWQLYLLWGLLGGGgaGTLAAVAFATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 181 WGSVFLInVPIVILALGLMVWLVPDSRDPRPGRldpvgvvlsvvglvllvygiikggeladfTDPKVLATIIAGVVVLAA 260
Cdd:cd17355 157 WRTALLV-LALLALLVLVPVLLLLRRRPADLAL-----------------------------RAYDDASPASPGSTLKEA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 261 filfekrsdhpsldvtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSvRGYSPLQSGLLMIPLAAAQMIFAPRARLV 340
Cdd:cd17355 207 -----------------LRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 341 VDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFlmGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQV 420
Cdd:cd17355 269 GDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQL 346
|
410
....*....|
gi 1154253362 421 GGALGIAVLG 430
Cdd:cd17355 347 GSALGPWLGG 356
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
71-203 |
5.56e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 5.56e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 71 AYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQ 150
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRR 314
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1154253362 151 PKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLV 203
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
58-432 |
1.69e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.97 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 138 LAVLMNVFEReEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInvPIVILALGLMVWLVPDSRDPRPGRLDPV 217
Cdd:COG2807 128 PGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAV--WALLALLALLLWLPLLRRRPAAAAAAPA 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 218 GVVLSVvglvllvygiikggeladftdpkVLATIIAGVVVLaafilfekrsdhpsldvtyfknkvfsaAMAAIALVFFAL 297
Cdd:COG2807 205 AASLRS-----------------------LWRSPLAWLLTL---------------------------FFGLQSLLYYAV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 298 MGvtFFSVFYTQsvRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALL--AGMLGAFAAFDADTPIWL 375
Cdd:COG2807 235 VA--WLPPILRD--AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLglAGLLGLLLAPGSLPWLWA 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 376 LevvffLMGAGMAHIMTPTSVVIMQALPR-EKAGSASALSNTFRQVGGALGIAVLGSV 432
Cdd:COG2807 311 V-----LLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
58-203 |
6.52e-10 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 61.19 E-value: 6.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:PRK10473 33 LNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVA 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1154253362 138 LAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFlinvpIVILALGLMVWLV 203
Cdd:PRK10473 113 FAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF-----YTMAAMGILVLLL 173
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
66-203 |
9.45e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.29 E-value: 9.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 66 EWAINAYTLvfaGLLFTAGLVG------------DRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFV 133
Cdd:cd17365 28 DWGLSPAQL---GPVGSAALFGmaigallagplaDRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAA 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 134 MPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN--VPIVILAL---GLMVWLV 203
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGgvPPLILLPLlrgTLLLWVT 179
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
74-212 |
1.16e-09 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 60.29 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 74 LVFAGLLFtaGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALG--AAFVMPATLavlmnVFEREEQP 151
Cdd:PRK11043 54 FALGQLLW--GPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGvcSAAVIWQAL-----VIDRYPAQ 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 152 KAIGIWAG---GVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPG 212
Cdd:PRK11043 127 KANRVFATimpLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQS 190
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-434 |
1.36e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.93 E-value: 1.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 57 GLGATQSELEWAINAYTLVFAGLLftAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPA 136
Cdd:cd17329 31 GLSASIVGLVLALSAVAGIVASLI--GGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 137 TLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFwWGSVFLINVPIVILALGLMVWLVPDSRDPRPgrldp 216
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS-FRLLFLAAAVLFLLAALVLLFLLPETRPKRR----- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 217 vgvvlsvvglvllvygiikggeladftdPKVLATIIAGVVVLaafilfekrsdhpsldvtyFKNKVFSAAMAAIALVFFA 296
Cdd:cd17329 183 ----------------------------AAEKTEILRGYKIV-------------------LRDRAFLLFLLASFLISLI 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 297 LMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAgmLGAFAAFDADTPIWLL 376
Cdd:cd17329 216 YFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFA--IGFAVLAFANTLAVLI 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1154253362 377 EVVFFLMGAGMahIMTPTSVVIMQAL-PREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:cd17329 294 LAMIVLTLGEM--LVFPAVQTLVAALaPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD 350
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
77-198 |
2.59e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 59.12 E-value: 2.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 77 AGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGI 156
Cdd:cd17474 249 LGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1154253362 157 WAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGL 198
Cdd:cd17474 329 YNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
23-201 |
3.09e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.74 E-value: 3.09e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 23 WAILGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGATQSELEW--AINAYTLVFAGLLFtAGLVGDRVGRKKVLLGGL 100
Cdd:cd17330 170 LFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLllALVGIAGILAQLLL-IPRLAKRLGERKLLRLGL 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 101 VVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFW 180
Cdd:cd17330 249 LLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
|
170 180
....*....|....*....|.
gi 1154253362 181 WGSVFLINVPIVILALGLMVW 201
Cdd:cd17330 329 PGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-436 |
7.62e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.63 E-value: 7.62e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 56 TGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMP 135
Cdd:cd17475 24 EDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 136 ATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInVPIVILALGLMVWLVpdSRDPRPGRLD 215
Cdd:cd17475 104 GGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV-AGLVSILAAVLFWLF--YREPPAASAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 216 PvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaafilfEKRSDHPSLDVTYFKNKVFSAAMAAIALVFF 295
Cdd:cd17475 181 T------------------------------------------------ESASTLLRSLKEVLRNRDVWLIAIAGALLVA 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 296 ALMGVTFFSVFYTQSVRGYSPLQSGLLmipLAAAQMIFAPrARLVV----DRF--GYRATTTAGLALLA-GMLGAFAAFD 368
Cdd:cd17475 213 PQFALLTFLLLFLHDHLGLSVVAAGAL---LAVAQLGGAL-GRIGLgrvsDRVfgGRRRPVLVITAAIAaAALLVLSLLS 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 369 ADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLSTA 436
Cdd:cd17475 289 PGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAT 356
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
22-435 |
9.87e-09 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 57.28 E-value: 9.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 22 RWAILGVLMLSLLIVVLDNSILNVAIKTISTPaptgLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLV 101
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEE----IGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 102 VFGIGSALAAESGSpgqLIAFRALMALGAAFV---MPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDH 178
Cdd:cd17312 77 LSALANIFMGFSTS---LWFFAVLWGLNGLFQsmgWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 179 FWWGSVFLINvpivilalglmvwlvpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiAGVVVL 258
Cdd:cd17312 154 YGWRAAFLVP----------------------------------------------------------------GIVGLV 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 259 AAFILFEKRSDHPSLDVTYfknkvfsaaMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRAR 338
Cdd:cd17312 170 VAIILFFFLRDSPPYVWVL---------SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 339 LVVDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLEVVF-FLMGAGMAHIMTPTSVVIMQALPREKA-GSASALSNT 416
Cdd:cd17312 241 LLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLlFLIGFFVGGPINLIGGAAAQDIGRKEAaGTATGFVGL 320
|
410
....*....|....*....
gi 1154253362 417 FRQVGGALGIAVLGSVLST 435
Cdd:cd17312 321 FGYLGASLAGLPLGYIIDH 339
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
20-432 |
1.68e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.79 E-value: 1.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 20 RRRWAILGVLMLSLLIVVLDNSILNVAIKTISTpaptGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGG 99
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKD----AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 100 LVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMpATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLL--- 176
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLD-VAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLIllg 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 177 -DHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLDPVGVVLSVvglvllvygiikggeladftdpkvlatiiagv 255
Cdd:COG0738 159 lSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSL-------------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 256 vvlaafilfekrsdhpsldvtyFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAP 335
Cdd:COG0738 207 ----------------------LKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRF 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 336 RARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLLEVVFFLMGAGMAhIMTPTSVVIMQALPREKAGSASALSN 415
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLA---PGPWLALIGLALVGLGLS-LMFPTIFSLALDGLGKRTAAAVSAVL 340
|
410
....*....|....*..
gi 1154253362 416 TFRQVGGALGIAVLGSV 432
Cdd:COG0738 341 IMGIVGGAIGPPLIGFL 357
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
74-434 |
2.09e-08 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 56.12 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 74 LVFAGLLFTAGLV-------GDRVGRKKVLL-----GGLVVFGIGSALAAEsgspgQLIAFRALMALGAAFVmPATLAVL 141
Cdd:cd17391 40 LAFSSTFLVSAIFspiwgrlADRYGRKPMLLraslgMAIVIGLMAFVTNVW-----QLLILRLLQGVFSGYV-PNATALI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 142 MNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDP-RPGRLDPVGVV 220
Cdd:cd17391 114 ASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPvEKKKMVSTKEV 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 221 lsvvglvllvygiikggeLADFTDPKvlatIIAGVVVLAAFILFEKRSDHPSLdvtyfknkvfsaamaaiALVFFALMG- 299
Cdd:cd17391 194 ------------------WNSVPNPS----LLISLFVTTFIIQLANQSIEPIL-----------------TLYIRQLMGd 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 300 ---VTFFsvfytqsvrgysplqSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFdadTPIWLL 376
Cdd:cd17391 235 asnLAFI---------------SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFV---QTPWQL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 377 EVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGiAVLGSVLS 434
Cdd:cd17391 297 GILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAG-PLLGSAIA 353
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
84-437 |
2.29e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.07 E-value: 2.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 84 GLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAafVMPATLAVLMNVFEREEQPKAIGIWAGGVGL 163
Cdd:cd17472 53 GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRTKAMALIGASIGI 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 164 AIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRPGRLdpvgvvlsvvGLVLLVYGIIKGGELADFT 243
Cdd:cd17472 131 AFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISE----------KEKKKLKKLLKNKRLLRLD 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 244 dpkvLATIIAGVVVLAAFILFEKRSDHPSLDVTYFKnKVFSAAMaaiaLVFFALMGvtFFSVFYTQSVRGYSPLQSGLLM 323
Cdd:cd17472 201 ----FSIFILHFVLMAFFYILPLLLTQLGGGKGQLW-KVYLPAI----LIGFILMV--PFVIYAEKKGKMKQVFVSSILL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 324 IPLAAAQMIFAPRARLVvdrfgyratttaglaLLAGMLGAFAAFDadtpiwLLEVVFflmgagmahimtpTSVVIMQALP 403
Cdd:cd17472 270 IAVGFLLLLFAATSLWL---------------LIIGLIIFFIGFN------LLEALL-------------PSLVSKIAPK 315
|
330 340 350
....*....|....*....|....*....|....
gi 1154253362 404 REKaGSASALSNTFRQVGGALGiAVLGSVLSTAY 437
Cdd:cd17472 316 EYR-GTAMGIYNTSQFLGSFLG-GALGGLLWGLL 347
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
244-464 |
3.21e-08 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 56.16 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 244 DPKVLATIIAGVVVLAAFILFE-KRSDHPSLDVTYFKNKVFSAAMAaiaLVFFALMGVTFFSVFYT---QSVRGYSPLQS 319
Cdd:cd17322 247 NSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKDRTILAACL---IDFFYFFSYYIFSDYLYtvlQVAVGESITSA 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 320 GLLMIPLAAAQMIFAPRARLVVDRFG-YRATTTAGLALLAGMLGAFAAF----DADTPIWLLEVvffLMGAGMAHIMTPT 394
Cdd:cd17322 324 TRITNLYSFVSTVAGIFVGFLIRKTRrYKVLVIIGVPLYIVGMGLLIRYrggsGSHGGIIGALI---LIGIGGGLFTYPV 400
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 395 SVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVlstaYRNSIEGKLGM-LPANLRDTAGESIEATL 464
Cdd:cd17322 401 QVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAI----WTQTLPKKLLKnLPDSLKATAAYIFPSTF 467
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-207 |
5.78e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.88 E-value: 5.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 23 WAILGVLMLSLLIVvldnsILNVAIKTISTPAPT----GLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGR--KKVL 96
Cdd:COG2271 177 LALLRFWLLALAYF-----LVYFALYGFLTWLPTylveVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 97 LGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLL 176
Cdd:COG2271 252 AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
170 180 190
....*....|....*....|....*....|.
gi 1154253362 177 DHFWWGSVFLINVPIVILALGLMVWLVPDSR 207
Cdd:COG2271 332 DATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-437 |
8.45e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 8.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 26 LGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGATQSELEWAINAYTLVFAGLLFtaGLVGDRVGRKKVLLGGLVVFGI 105
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLF--GYLGDRIGRKKALILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 106 GSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFW----W 181
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 182 GSVFLINVPIVILALGLMVWLVpdsrdprpgrldpvgvvlsvvglvllvygiikggeladftdpkvlatiiagvvvlaaf 261
Cdd:cd17316 159 RILFLIGALPALLALLLRRRTL---------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 262 ilfekrsdhpsldvtyfknkvfsaamAAIALVFFALMGVTFFSVF---YTQSVRGYSPLQSGLLMIPLAAAQMIFAPRAR 338
Cdd:cd17316 181 --------------------------LLILLWFFISFGYYGLTTFlptYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 339 LVVDRFGyRATTTAGLALLAGMLGAFAAFDADTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFR 418
Cdd:cd17316 235 LLSDRIG-RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLG 313
|
410
....*....|....*....
gi 1154253362 419 QVGGALGIAVLGSVLSTAY 437
Cdd:cd17316 314 RLGGGGAPPLIALLLASTG 332
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
69-425 |
8.80e-08 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 54.56 E-value: 8.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 69 INAYTLVFAGLLFTAG-LVGD--------RVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLA 139
Cdd:cd17327 38 LVGNQYNWGNTVFYVGyIIFElpgnlllqRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFIL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 140 VLMNVFEREEQPKAIGIWAGgvglAIAIGPITGGLLLDHFW----------WGSVFLInVPIVILALGLMV-WLVPDsrD 208
Cdd:cd17327 118 YLGMWYKREEQAKRIAFFYA----AAGLGSIFGGLLAYGVFkilgvgglagWRWLFII-EGLITIIIGLVIfFWLPD--N 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 209 PRPGRLdpvgvvlsvvglvllvygiikggeladFTD-PKVLATIiagvvvlaafilfEKRSDHPSLDVTYFKNKVFSAAM 287
Cdd:cd17327 191 PSKAWF---------------------------LTEeEKELAVE-------------RLRANQTGKGDQKFKWKQIKEAF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 288 A-----AIALVFFALMGVTFFSVFYT---QSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAg 359
Cdd:cd17327 231 KdprtwLLFLFFFCSQITNNGISNFLpliLKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLA- 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154253362 360 MLGAFAAFDADTPIWLLEVVFFL-MGAGMAHIMTPTSVVIMQALPREKAgSASALSNTFRQVGGALG 425
Cdd:cd17327 310 LVGSIILLAAPNPPGAYFAAYILgGGSYAGFPILLSWISSNCAGYTKRA-TVLAIMLIFYNVGNIVA 375
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
84-207 |
2.57e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 52.58 E-value: 2.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 84 GLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVmPATLAVLMNVFEREEQPKAIGIWAGGVGL 163
Cdd:cd17330 55 GRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGL 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1154253362 164 AIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSR 207
Cdd:cd17330 134 GFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLR 177
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
84-211 |
2.62e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 52.99 E-value: 2.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 84 GLVGDRVGRKKVLLG-GLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLmNVFEREEQPKAIGIWAGGVG 162
Cdd:cd17490 52 GILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYA-SYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1154253362 163 LAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPRP 211
Cdd:cd17490 131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKP 179
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
71-200 |
3.27e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 3.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 71 AYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQ 150
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELR 321
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1154253362 151 PKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMV 200
Cdd:cd17370 322 GTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
83-210 |
3.96e-07 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 52.83 E-value: 3.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 83 AGLVGDRVGRKKVLLGGLVVFGIGSALAAESG-----SPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIW 157
Cdd:pfam05977 65 AGALADNFDRRKIMLAGQLLLALVSTLLTLLAglgllSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALN 144
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1154253362 158 AGGVGLAIAIGPITGGLLLDHFWWGSVFLINVP---IVILALGLMVWLVPDSRDPR 210
Cdd:pfam05977 145 SVGYNIARSVGPALGGVLLAAFGPAFTFALNALsyfAVIAALWRWKRAAPASPLPR 200
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
83-216 |
4.39e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 52.24 E-value: 4.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 83 AGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVG 162
Cdd:cd17328 54 FGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIP 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 163 LAIAIGPITGGLLLDHFW-WGSVFLInVPIVILALGLMVWLVPdsRDPRPGRLDP 216
Cdd:cd17328 134 LGSGLGYVVGGLVAQATGgWRWAFRV-TGVLGVLLAILLLLFV--REPPRGAAEG 185
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
58-430 |
7.09e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 51.40 E-value: 7.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLV--FAGLLftAGLVGDRVG-RKKVLLGGLVVFgIGSALAAESGSPGQLI-AFRALMALGAAFV 133
Cdd:cd17352 33 FGESTSDIAWIGSLLLGVslFSGPL--SSALVNRFGcRPVAIAGGLLAA-LGLLLSSFATSLWQLYlTYGVLGGLGLGLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 134 MPATLAVLMNVFEREeQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInvpivilalglmvwlvpdsrdprpgr 213
Cdd:cd17352 110 YSPAIVIVGQYFEKK-RGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI-------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 214 ldpvgvvlsvvglvllvygiikggeladftdpkvLATIIAGVVVLAAFILFekrsdhpsldvtyFKNKVFSAAMAAIALV 293
Cdd:cd17352 163 ----------------------------------LGGLCLNLCVCGLLLRL-------------LKDPTFVLLALGVSFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 294 FFALMGVTFFSVFYTQSvRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFDADTpI 373
Cdd:cd17352 196 MLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT-Y 273
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1154253362 374 WLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLG 430
Cdd:cd17352 274 VGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAG 330
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-179 |
1.35e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 50.67 E-value: 1.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALA--AESGSPGQLIAFRALMALGAAFVMP 135
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLffLGPGNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 136 ATLAVLMNVFEREEQP-------KAIGIWAGGVGLAIAIGPITGGLLLDHF 179
Cdd:COG2211 339 LPWAMLADVVDYDEWKtgrrregLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
31-202 |
1.46e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 50.68 E-value: 1.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 31 LSLLIVVLdnsilnVAI----KTISTPA----PTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVV 102
Cdd:PRK11652 9 LLFMLVLL------VAVgqmaQTIYVPAiadmARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 103 FGIGSALAAESGSPGQLIAFRAL--MALGAAFVMPATLAvlMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFW 180
Cdd:PRK11652 83 FILGTLVALFAHSLTVLIAASAIqgLGTGVGGVMARTLP--RDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG 160
|
170 180
....*....|....*....|..
gi 1154253362 181 WGSVFLinvpiVILALGLMVWL 202
Cdd:PRK11652 161 WRACYL-----FLLLLGAGVTF 177
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
58-213 |
2.10e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.96 E-value: 2.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLvfaGLL---FTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVM 134
Cdd:PRK11551 45 FGLDVAQMGWAFSAGIL---GLLpgaLLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGAL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 135 PATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLIN--VPIVILALgLMVWLvPDSRDPRPG 212
Cdd:PRK11551 122 PNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGgvGPLLLVPL-LMRWL-PESRAFAQA 199
|
.
gi 1154253362 213 R 213
Cdd:PRK11551 200 A 200
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
58-434 |
2.15e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 50.07 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 58 LGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPAT 137
Cdd:TIGR00881 25 IGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPC 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 138 LAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFW-WGSVFLINVPIVILALGLMVWLVPDSRdprpgrldp 216
Cdd:TIGR00881 105 GRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYsWHWVFIVPGIIAIIVSLICFLLLRDSP--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 217 vgvvlsvvglvlLVYGIIKGGElaDFTDPKVLATIIAGVVVLAAFILFEKRSDHPSLDVTYFKNkvfsaamaaiALVFFA 296
Cdd:TIGR00881 176 ------------QSCGLPPAEE--MPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGY----------VFVYVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 297 LMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGM---LGAFAAFDADTPI 373
Cdd:TIGR00881 232 RTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIivsLLVYWLNPAANPL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 374 WLLevvFFLMGAGMAhIMTPTSVVIMQAL---PREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:TIGR00881 312 MDL---ICLFALGFL-VYGPQMLIGVIASelaPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
76-415 |
2.56e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.96 E-value: 2.56e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 76 FAGLLFtAGLVGDRVGRKKVLLGGLVVFGIGSALAAES---GSPGQLIAFRALMALGAAFVmpatlAVLMNVFEREEQPK 152
Cdd:pfam00083 60 FIGSLF-AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGA-----SVLAPMYISEIAPK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 153 AI-GIWAGGVGLAIAIGPITG---GLLLDHF-----WWGSVFLINVPIVILALGLMVWlvPDSrdPRpgrldpvgvvlsv 223
Cdd:pfam00083 134 KLrGALGSLYQLAITFGILLAyifGLGLNKTsnsdgWRIPLGLQLVPALLLIIGLLFL--PES--PR------------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 224 vglvllvYGIIKGGELAD-------FTDPKVLATIIAGVVVLAAFILFEKRSDHPSLDVTYFKNKVFSAAMAAIALVFFA 296
Cdd:pfam00083 197 -------WLVEKGRLEEArevlaklRGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 297 LMGVTFFSVFYTQSVrGYSPlqSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGM---LGAFAAFDADTPI 373
Cdd:pfam00083 270 INAIFYYSTTIFENL-GLSD--SFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICfviLGIVALLGVSKSD 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1154253362 374 WLLEV-VFFLMGAGMAHIMTPTSV--VIMQAL----PREKAGSASALSN 415
Cdd:pfam00083 347 WAGIVaIVFIALFIAFFAMGWGPVpwVIVSELfplsVRSKAMALATAAN 395
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
275-435 |
2.83e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 275 VTYFKNKVFSAAMAAIALVFFALMGVTFFSVFYTQSVrGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGL 354
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADL-GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 355 ALLAGMLGAFAAFDAdtpIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:COG2271 83 LLWGLATLLFGFATS---FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
.
gi 1154253362 435 T 435
Cdd:COG2271 160 A 160
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
57-200 |
3.24e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 49.53 E-value: 3.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 57 GLGATQSELEWAINAYTLVFA-GLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMP 135
Cdd:cd17490 224 QLGASSFQLGLLSIIYLLPNAlASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFP 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 136 ATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMV 200
Cdd:cd17490 304 LLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
73-196 |
4.12e-06 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 49.19 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 73 TLVFAGLLftaGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPK 152
Cdd:cd17391 253 SLLSAPRL---GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGR 329
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1154253362 153 AIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILAL 196
Cdd:cd17391 330 IFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNA 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
285-438 |
4.18e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 4.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 285 AAMAAIALVFFALMgvtFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAF 364
Cdd:cd17329 6 IGSFLNRLGFFMVW---PFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 365 AAFDAdtpIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSVLSTAYR 438
Cdd:cd17329 83 GFAHS---PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR 153
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
65-202 |
7.48e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 48.40 E-value: 7.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 65 LEWAINAYTLVFAGLLFTAGLVG---DRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVL 141
Cdd:PRK15402 47 AEWVPTSMTAYLAGGMFLQWLLGplsDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAI 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 142 MNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInvpivILALGLMVWL 202
Cdd:PRK15402 127 QESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVL-----FAALAALSFF 182
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
46-216 |
1.28e-05 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 47.73 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 46 AIKTISTPAPTG-----LGATQSELEWAINAYTLVFAGLlfTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLI 120
Cdd:cd17362 19 ALLSITSPALSGtdwynLSSLQSGLVVSGSLLGALLGSL--VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 121 AFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMV 200
Cdd:cd17362 97 VGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGM 176
|
170
....*....|....*.
gi 1154253362 201 WLVPDSRDPRPGRLDP 216
Cdd:cd17362 177 WFLPPSPRWQGNYRKP 192
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
68-196 |
1.29e-05 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 47.62 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 68 AINAYTLVFAGLLftAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAA--FVMPATLAVLMNVF 145
Cdd:cd17313 288 LIFSLAFLIFSLP--IGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWAtiNINPYPLVSDYHSE 365
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 146 EREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILAL 196
Cdd:cd17313 366 SGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSL 416
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
287-437 |
1.45e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.41 E-value: 1.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 287 MAAIALVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAA 366
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1154253362 367 FdadTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGiAVLGSVLSTAY 437
Cdd:pfam07690 82 A---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALG-PLLGGLLASLF 148
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
68-209 |
2.16e-05 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 46.84 E-value: 2.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 68 AINAYT-LVFA-GLLFTA------GLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVmPATLA 139
Cdd:PRK09874 51 ALNMWSgLVFSiTFLFSAiaspfwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFV-PNANA 129
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 140 VLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDP 209
Cdd:PRK09874 130 LIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQP 199
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
280-434 |
2.22e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 2.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 280 NKVFSAAMAAIALVFF---ALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLAL 356
Cdd:COG0738 3 KKNYRRALIAIYLLFFlwgFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 357 LAGMLGAFAAFdadTPIWLLEVVFFLMGAGMAHIMTPTSVVIMqALPREKAGSASALSNTFRQVGGALGIAVLGSVLS 434
Cdd:COG0738 83 MALGLLLFALA---PSYPLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLLHAFFSLGALLGPLLGGLLIL 156
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
28-187 |
2.39e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.78 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 28 VLMLSLLIVVL--DNSILNVAIktisTPAPTGLGATQSELEWAINAYtlvFAGLLFT---AGLVGDRVGRKKVLLGGLVV 102
Cdd:cd17380 1 VILLFLATCICyaDRVNMPIAI----VPMAKEFGWSKTDQGLVLSSF---FWGYALTqvlGGYLADRFGGKKVLLLAVAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 103 FGIGSAL---AAESGSPGqLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHF 179
Cdd:cd17380 74 WSLATLLtplLAYSSLPL-LILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYY 152
|
....*...
gi 1154253362 180 WWGSVFLI 187
Cdd:cd17380 153 GWPSVFYF 160
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
19-203 |
2.65e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.45 E-value: 2.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 19 HRRRWAILGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGatqseLEWAINAyTLVFAGLLFTAGLVGdRVGRKKVLLG 98
Cdd:cd17329 199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLG-----LLLALNA-LLIVLLQFPVARLVE-RFRLRKILMI 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 99 GLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDH 178
Cdd:cd17329 272 GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDL 351
|
170 180
....*....|....*....|....*
gi 1154253362 179 FWWGSVFLINVPIVILALGLMVWLV 203
Cdd:cd17329 352 LGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
17-200 |
4.07e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 46.06 E-value: 4.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 17 AVHRRRWAILGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGATQSelewAINAYTLVFAGLLftAGLVGDRVGRKKVL 96
Cdd:cd17331 204 LRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMS----YAGVLGMVVQGLL--VGPLTKRFGERSLL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 97 LGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLL 176
Cdd:cd17331 278 KLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALL 357
|
170 180
....*....|....*....|....
gi 1154253362 177 DHFWWGSVFLINVPIVILALGLMV 200
Cdd:cd17331 358 QAYGFPSFGLLGAAINGLLTVYLL 381
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
73-367 |
4.35e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 73 TLVFAGLL---FTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFErEE 149
Cdd:cd17333 38 SSQNAGYLigsLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ES 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 150 QPKAIGIWAGGVGLAIAIGPITGGLLLD-HFWWGSVFLInvpIVILALGLMVWLVPDSRDPRPGRLDPVGVVLSVVGLVL 228
Cdd:cd17333 117 SATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLI---IGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASAS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 229 LVYGIIKGGELADFTdpkvLATIIAGVVVLAAFILFEKRSDHPS-------------------LDVTYFKNKVFSAAMAA 289
Cdd:cd17333 194 RLLRNPSIILGALAL----FLYVGAETAFSSWVPSYLVEKKHVSdglagyllsgfwvgitigrLLGGPISRRIKPHTLLV 269
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1154253362 290 IAlVFFALMGVTFFSVFYTQSVRGYSPLQSGLLMIPLAAAQMIFAprarlvVDRFGYRATTTAGLALLAGMLGAFAAF 367
Cdd:cd17333 270 LS-GSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLG------ISNLPYAKGKGTSVLLAAGSIGGAIIP 340
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
285-437 |
5.07e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 285 AAMAAIALVFFALMGVTFFSVFYTQSVR--GYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLG 362
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAAdlGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 363 AFAAfdADTPIWLLeVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGiAVLGSVLSTAY 437
Cdd:COG2814 91 LCAL--APSLWLLL-AARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG-PLLGGLLADLF 161
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
76-200 |
6.87e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.11 E-value: 6.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 76 FAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIG 155
Cdd:cd06174 253 ALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1154253362 156 IWAGGVGLAIAIGP-ITGGLLLDHFWWGSVFLINVPIVILALGLMV 200
Cdd:cd06174 333 LLNTFGFLGGAIGPlLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
286-429 |
8.18e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.92 E-value: 8.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 286 AMAAIALVFFALMGVTFFSVFYtQSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFA 365
Cdd:cd17475 1 ATLAQAAASLVAQGIPALAPFL-QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 366 AFdadTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVL 429
Cdd:cd17475 80 LV---GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALL 140
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
82-202 |
8.96e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 44.99 E-value: 8.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 82 TAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGI----W 157
Cdd:cd17371 53 LGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYvqsgW 132
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 1154253362 158 AGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWL 202
Cdd:cd17371 133 AVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFV 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
81-202 |
9.90e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 9.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 81 FTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGG 160
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNAL 341
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1154253362 161 VGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWL 202
Cdd:cd06173 342 NSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
66-202 |
2.24e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 43.69 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 66 EWAINAYTLVFAGLL---FTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLM 142
Cdd:COG0738 246 ATAALGLSLFWGGMTigrFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLAL 325
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 143 NVFEReEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWL 202
Cdd:COG0738 326 DGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
62-202 |
2.50e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 43.66 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 62 QSELEWAINAYTLVFAGLLFTAGLVG---DRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATL 138
Cdd:PRK15403 47 NADVSLAPASVSLYLAGGMALQWLLGplsDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGY 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1154253362 139 AVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInvpivILALGLMVWL 202
Cdd:PRK15403 127 VTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAI-----IAVMGLIAFV 185
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
76-210 |
2.69e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 43.39 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 76 FAGLLFtAGLVGDRVGRKKVLLGGLVVFGIGSALA-AESGSPGQLIAFRALMALGAAFvmpatLAVLMNVFEREEQPKAI 154
Cdd:cd17356 59 FFGALI-SSFLSDRIGRKKSIQIGCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLGVGF-----ASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 155 -GIWAGGVGLAIAIGPITG-------GLLLDHFWWGSVFLIN-VPIVILALGlmVWLVPDSrdPR 210
Cdd:cd17356 133 rGTLVSLYQLAITIGILVAycinygtHKLDGSAQWRIPLGLQiVWGLLLLIG--MFFLPES--PR 193
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
25-202 |
2.93e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 2.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 25 ILGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGATQSELEWAINAYTLVFAGLLFT----AGLVGDRVGRKKVLLGGL 100
Cdd:cd17316 171 LALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVgaliAGLLSDRIGRKKTLVIGL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 101 VVFGIGSALA--AESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDH 178
Cdd:cd17316 251 ILSGILALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|....
gi 1154253362 179 FWWGSVFLINVPIVILAlGLMVWL 202
Cdd:cd17316 331 TGGTGVPALILALLAIV-ALIVAL 353
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
54-269 |
3.51e-04 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 43.29 E-value: 3.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 54 APTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRV--GRKKVLLGGLVVFgIGSALAAESGSPGQLIAFRALMALGAA 131
Cdd:TIGR00924 39 QQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVwgTKKTMVLGGIVLM-LGHFMLAMSIYPDLIFYGLGTIAVGSG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 132 FVMPATLAVLMNVFEREEQPK---AIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFliNVPIVILALGLMVWLV----- 203
Cdd:TIGR00924 118 LFKANPSSMVGKLYERGDMPRrdgGFTLFYMSINIGSFISPLLAGVIAENYGYHVGF--NLAAVGMVIGLLTFFAgrhml 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154253362 204 ---PDSRDPRPGRLDPVGVVLSVVGLVLLVYGIIKGGELADFTDPKVLATIIAGVVVLAAFILFEKRSD 269
Cdd:TIGR00924 196 rdiGSVPDPLSGQGKTYGKLLLALLAALALVFFCAWLMHHVVIANILLMTVTLAVIIFFFRLAFKPRLD 264
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
81-187 |
8.43e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.84 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 81 FTAGLVGDRVGRKKVLLGGLVVFGIGSAL---AAESGSPGqLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIW 157
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLtplAARGGYGA-LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
90 100 110
....*....|....*....|....*....|
gi 1154253362 158 AGGVGLAIAIGPITGGLLLDHFWWGSVFLI 187
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCESLGWPSIFYI 182
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
119-433 |
9.68e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 41.84 E-value: 9.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 119 LIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGS--------VFLINVP 190
Cdd:cd17313 108 FVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWFGFalggnlkvPFYIGAI 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 191 IVILALGLMVWLVPDSRDPrpgrldpvgvvlsvvglvllvygIIKGGELADFTDPKVLATIIAGVVvlaafilfekrsdh 270
Cdd:cd17313 188 ILLVCVLVTLFFVKEPPLS-----------------------PEAGEHSENPSLGEVLKSLLKLLK-------------- 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 271 psldvtyFKNKVFSAAMAAIALVFFALMGV-TFFSVFYTQSVRGYSPLQS----------GLLMIPLAAAQMIFAPRARL 339
Cdd:cd17313 231 -------IMPRSLLRLLLVIFFWWIAFFPFeLFFTDYMGEEVYHGTSAASshygagvrmgAWGLLIFSLAFLIFSLPIGK 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 340 VVDRFGYRATTTAGLALLAGMLGAFAAFDAdtpIWLLEVVFFLMGAGMA--HIMTPTSVVIMQALPREKAGSASALSNTF 417
Cdd:cd17313 304 LGKKIGRKKVYLIGLVLFAVGMALMALVHN---VTVALVLFALGGIGWAtiNINPYPLVSDYHSESGRGQGTDTGLLNLA 380
|
330
....*....|....*.
gi 1154253362 418 RQVGGALGIAVLGSVL 433
Cdd:cd17313 381 ISLAQILVSLLAGPII 396
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
292-402 |
1.02e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 41.42 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 292 LVFFALMGVT--FFSVFYTQsvRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRaTTTAGLALLAGMLGAFAAFDA 369
Cdd:cd17335 7 FFFFAALGSLlpFLSVYLKQ--LGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKR-KALLLLSLLAAVLFFLSLFFV 83
|
90 100 110
....*....|....*....|....*....|...
gi 1154253362 370 DTPIWLLEVVFFLMGAGMAHIMTPTSVVIMQAL 402
Cdd:cd17335 84 AQIFWLLLLLVILGAFFSAPVVPLVDSITLQYL 116
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-169 |
1.14e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 24 AILGVLMLSLLIVVLDNSILNVAIKTISTPAPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKK---VLLGGL 100
Cdd:pfam07690 196 ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLL 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154253362 101 VVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGP 169
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
248-430 |
1.26e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 41.37 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 248 LATIIAGVVVLAAFILFEKRSDHPSLDVTYFKN---KVFSAAMAaIALVFFALMGVTFFSV---FYTQSVRGYSPLQSGL 321
Cdd:cd17370 160 LLAAIPALLALLILLFVVKEYPRPPKLRKKSKKtslKKLPKAFW-LYLLAVALFALGNFSFaflILRAQELGLSAALIPL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 322 LMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGMLGAFAAFDADTPIWLLevvFFLMGAGMAHIMTPTSVVIMQA 401
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLG---FILWGLYMGAQESIERAAVADL 315
|
170 180
....*....|....*....|....*....
gi 1154253362 402 LPREKAGSASALSNTFRQVGGALGIAVLG 430
Cdd:cd17370 316 VPAELRGTAYGLFNTVVGIGWLLASLIAG 344
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
76-209 |
2.09e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 40.37 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 76 FAGLLFTAGLVGdRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVFEREEQPKAIG 155
Cdd:cd06180 48 LVGALLASFLRR-RGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIG 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1154253362 156 IWAGGVGLAIAIGPITGGLLLDHFW-WGSVFLINVPIVILALGLMVWLVPDSRDP 209
Cdd:cd06180 127 LLFAGVGLGIALSGLLVPAGLGGGLsWRAGWLALALLSAVLLLLSFLLLRRGPSA 181
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
80-197 |
2.25e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 40.25 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 80 LFTAGLVG---DRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVF-EREEQPKAIG 155
Cdd:cd17384 45 LITNPIVGpltNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYpDDKERGKAMG 124
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1154253362 156 IWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInvpIVILALG 197
Cdd:cd17384 125 IALGGLALGVLVGPPFGGVMYEFVGKSAPFLI---LAFLALL 163
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
282-432 |
2.43e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 282 VFSAAMAAIAL-VFFALMGVTFFSvfytqsvRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLALLAGM 360
Cdd:cd17477 2 LLSVALLGLGSgLLLPLLSLRLER-------EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVS 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1154253362 361 LGAFAAFDadtPIWLLEVVFFLMGAGMAHIMTPTSVVIMQALPREKAGSASALSNTFRQVGGALGIAVLGSV 432
Cdd:cd17477 75 VLLLALTD---SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV 143
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
81-203 |
2.73e-03 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 39.99 E-value: 2.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 81 FTAGLVgDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLMNVF-EREEQPKAIGIWAG 159
Cdd:cd17383 49 FSGTLI-DRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFtEEAERSKALGIALA 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1154253362 160 GVGLAIAIGPITGGLLLDHFwwGSvfliNVPIVILAL-----GLMVWLV 203
Cdd:cd17383 128 FISFGCLVAPPFGGILYEFA--GK----EVPFLILAFvclldGLLLLLV 170
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-201 |
4.10e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 10 SGPRIPEAVHRRRWAILGVLMLSLLIVVLdNSILNVAIKTISTPAPTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDR 89
Cdd:cd17477 171 AAPEIEEAESISLRRLLRIAPLALLGAFV-AGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 90 VGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVM-PATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIG 168
Cdd:cd17477 250 FDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLyTLALALAGDRLPGDELVAANAALLLLYGLGSVIG 329
|
170 180 190
....*....|....*....|....*....|...
gi 1154253362 169 PITGGLLLDHFwwGSVFLINVPIVILALGLMVW 201
Cdd:cd17477 330 PLLAGALMDAF--GPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
54-210 |
5.54e-03 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 39.28 E-value: 5.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 54 APTGLGATQSELEWAINAYTLVFAGLLFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFV 133
Cdd:pfam06779 21 AEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLLATVLLLLAMAATSSFWAVLLIRFLAGVASAAV 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1154253362 134 MPATLAVLMNVFEREEQPKAIGIWAGGVGLAIAIGPITGGLLLDHFWWGSVFLINVPIVILALGLMVWLVPDSRDPR 210
Cdd:pfam06779 101 MIFGSSLILGHATAARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLSAVLTLAVFPLLPRRAPR 177
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
67-142 |
8.11e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.72 E-value: 8.11e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1154253362 67 WAINAYTLVFAGLL---FTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRALMALGAAFVMPATLAVLM 142
Cdd:cd17317 26 LVALVQTIFFLGVLigsLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGM 104
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
80-432 |
8.55e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 38.68 E-value: 8.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 80 LFTAGLVGDRVGRKKVLLGGLVVFGIGSALAAESGSPGQLIAFRA-LMALGAAfVMPATLAVLMNVFER---EEQPKAIG 155
Cdd:cd17471 50 QWLGRLSDRGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVvLLSLGAA-AFPQLFALAREYADRssgRDATLFNS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 156 IWAGGVGLAIAIGPITGGLLLDHFWWGSVFLInVPIVILALGLMVWLVPDSRDPRPgrldpvgvvlsvvglvllvygiIK 235
Cdd:cd17471 129 VLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL-AALLYLVVALLVLFLLPSVKPPA----------------------QK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 236 GGELADFTDPKVLATIiagVVVLAAFILFekrsdhpsldvtyfknkvfSAAMAaialvffalMGVTFFSVFYTQSVRGyS 315
Cdd:cd17471 186 ATPASSLVKAPVNRRL---LLLFAAFTLL-------------------FAANS---------MYIIAMPLYVTNELGG-S 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 316 PLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAGLalLAGMLGaFAAFDADTPIWLLEVVFFLMGAGMAhIMTPTS 395
Cdd:cd17471 234 ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGF--LAGVLF-YLGLALATSLWQLIALQLLNAIFIG-ITAGLG 309
|
330 340 350
....*....|....*....|....*....|....*...
gi 1154253362 396 VVIMQALPREKAGSASAL-SNTFRqVGGALGIAVLGSV 432
Cdd:cd17471 310 ISYFQDLMPGQPGLATTLySNASR-IGSLLGGLLAGVI 346
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
287-398 |
9.55e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 9.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1154253362 287 MAAIALVFFALMGVTF-FSVFYT--QSVRGYSPLQSGLLMIPLAAAQMIFAPRARLVVDRFGYRATTTAG--LALLAGML 361
Cdd:cd17352 5 VFASFLVNFFTDGILNsFGVLFVelLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGglLAALGLLL 84
|
90 100 110
....*....|....*....|....*....|....*...
gi 1154253362 362 GAFAafdadTPIWLLEVVF-FLMGAGMAHIMTPTSVVI 398
Cdd:cd17352 85 SSFA-----TSLWQLYLTYgVLGGLGLGLIYSPAIVIV 117
|
|
| |
