|
Name |
Accession |
Description |
Interval |
E-value |
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-428 |
1.41e-49 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 174.18 E-value: 1.41e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQH 80
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 81 LSLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPF 160
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 161 KGYLIELPVNMAMSYVLIHGLagfeGIGVQGAAAGSLIAITIRLSY-LTLCIKLDDSIVLSTKNLdaslkRNTLNHFKEI 239
Cdd:COG0534 161 IIMLIGNVLNIVLDPLLIFGG----GLGVAGAALATVISQAVSALLlLYYLFRKRSLLRLRLRDL-----RPDRKILKRI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 240 F----PVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELRKNVDIS 315
Cdd:COG0534 232 LriglPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLA 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 316 IDMAVMISFVSAAFFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINFTGQWI 395
Cdd:COG0534 312 LLLALGIGLLLALLLFLFPEPIIGLFTD-DPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWL 390
|
410 420 430
....*....|....*....|....*....|...
gi 1159780652 396 VSIPLcALIILHWDLSFFWAFAVMPFEEIVKAL 428
Cdd:COG0534 391 VRLPL-AYLLAFLGLGLTGVWLALPIGEVLRAL 422
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-430 |
4.06e-47 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 168.06 E-value: 4.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAG 90
Cdd:cd13134 6 FALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 91 LIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVN 170
Cdd:cd13134 86 LLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNILN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 171 MAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKnldaSLKRNTLNHFKEIF----PVAANV 246
Cdd:cd13134 166 IVGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLK----DLRPFPKKLLKKILkiglPSAGEE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 247 TMLQTGATIYMLLYSQLTLNAYVAMTIVMPWikagTQFITAWAHS----SAITISQAIGSRQMDELRKNVDISIDMAVMI 322
Cdd:cd13134 242 LSYNLSQTVITAFIARLGTAALAARTYASNI----SMFVFLFSLAigqaTQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 323 SFVSAAFFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIVSIPLCA 402
Cdd:cd13134 318 SLAVALLLALFREPILGLFTD-DPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAY 396
|
410 420
....*....|....*....|....*...
gi 1159780652 403 LIILHWDLSFFWAFAVMPFEEIVKALPF 430
Cdd:cd13134 397 LLGIVLGLGLLGVWIAFAADEWVRGIIM 424
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
8-428 |
1.84e-44 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 160.76 E-value: 1.84e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 8 RKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGF 87
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 88 WAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIEL 167
Cdd:cd13137 81 GQSLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 168 PVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITI---RLSYLTLCIKLDDSIVLSTKNLDASLkrntlnhFKEIF---- 240
Cdd:cd13137 161 VLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVgalLLLFLLLRGRLPIKISFKGFRLDRKI-------IKKLLrigl 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 241 PVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMpwiKAGTQ-FITAWAHSSAITI--SQAIGSRQMDELRKNVDISID 317
Cdd:cd13137 234 PAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGL---RIESLaFMPGFGFSMAASTlvGQNLGAGDPDEARRYGKRALR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 318 MAVMISFVSAAFFLALSFVLPDLYPDlDPTTyVALASIAPLYILL-PIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIV 396
Cdd:cd13137 311 LGVLFMGLLGLLLFIFAPPLASLFTP-DPEV-IELGVLYLRIVALsQPFLAISFVLSGALRGAGDTRPPLIINLISMWLV 388
|
410 420 430
....*....|....*....|....*....|..
gi 1159780652 397 SIPLCALIILHWDLSFFWAFAVMPFEEIVKAL 428
Cdd:cd13137 389 RLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAI 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-418 |
3.49e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 127.26 E-value: 3.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKG 86
Cdd:cd13133 4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 87 FWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIE 166
Cdd:cd13133 84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVM 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 167 LPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIA-ITIRLSYLTLCIKLDDSIVLSTknldASLKRNTLNHFKEI----FP 241
Cdd:cd13133 164 VVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAeAVSLLFFLLLLFRRKNRRRFGL----RRAWRFDRELLRRIlrlgLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 242 VAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPWikAGTQFITAWAHSSAITI--SQAIGSRQMDELRKNVDISIDMA 319
Cdd:cd13133 240 SGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSI--NSLAFLPMIGLGIAVSSlvGQALGAGRPDLAMRVTRRGLKLA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 320 VMISFVSAAFFLALSFVLPDLYPDLDPTTYVALASIAPLYILL--PIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIVS 397
Cdd:cd13133 318 LAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPLLRFVAayILFDALALVFAGALRGAGDTRFVMLAELIVAWLYL 397
|
410 420
....*....|....*....|..
gi 1159780652 398 IPLC-ALIILHWDLSFFWAFAV 418
Cdd:cd13133 398 LPPAyLLVVLGAGLAGAWTVET 419
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
14-403 |
3.61e-26 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 109.72 E-value: 3.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 14 AWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAGLII 93
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 94 NVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVNMAM 173
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 174 SYVLIHGLAGFEGiGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKNLDASLKRNTLNHFKEIFPVAANVTMLQTGA 253
Cdd:cd12082 161 DPLLIFGLGPPEL-GIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 254 TIYMLLYSQLTLNAYVA-MTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELRKnvdiSIDMAVMISFVSAAFFLA 332
Cdd:cd12082 240 LIIVAIVAAFGGAAALAaYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARR----ITWVALLIGLLIGAVLGL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1159780652 333 LSFVLPDLYPDL---DPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIVSIPLCAL 403
Cdd:cd12082 316 LILLFPEPILSLftnDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYV 389
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
6-418 |
1.84e-25 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 107.97 E-value: 1.84e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 6 YIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIAT----TIVSFVLGIQMALANgsqlVLSRAVGSGQHL 81
Cdd:cd13131 1 ELRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSslwfPVFTFGMGLLLAVTP----LVAQAHGAGDRR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 82 SLNKGFWAGLIINVLVAVLFWILITAFDKAL-ISKLTDNVAlyAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPF 160
Cdd:cd13131 77 RIRRAVRQGLWLALLLSLPLMLLLWLAPPILpLMGQEPEVA--AIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAM 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 161 KGYLIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLTLCIKLDdsIVLSTKNLDASLKRNTLNHFKEIF 240
Cdd:cd13131 155 VITLLALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRH--KRFRRYRLFARFWRPDWARLKELL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 241 ----PVAANV---TMLQTGATIYMLLYSQLTLNAY-VAMTIvmpwikAGTQFITAWAHSSAITI--SQAIGSRQMDELRK 310
Cdd:cd13131 233 rlglPIGLTIffeVSLFAAVALLMGRLGTTVLAAHqIALNF------ASLLFMVPLGISMAATVrvGFALGAGDPADARR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 311 NVDISIDMAVMISFVSAAFFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINF 390
Cdd:cd13131 307 AGLVGLGLGVGFAALTALLLLLFPEQIAGLYTN-DPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLLAL 385
|
410 420 430
....*....|....*....|....*....|.
gi 1159780652 391 TGQWIVSIPLCALIILHWDL---SFFWAFAV 418
Cdd:cd13131 386 ISYWGIGLPLGYLLAFTTGLgafGVWIGLII 416
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-334 |
8.03e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 102.99 E-value: 8.03e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNL-SLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNK 85
Cdd:cd13140 3 ILKTLlRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWILITAFDKALIS--KLTDNVALyAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGY 163
Cdd:cd13140 83 YARNALQLNLLLGILYGLLLLLFAKPLIGffNLGDAEVI-SLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIIN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 164 LIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKnldaSLKRNTLNHFKEI---- 239
Cdd:cd13140 162 AIGLVLNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIR----ILKRPDRKYIKEIlklg 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 240 FPVAanvtmLQTG--ATIYMLlysqltLNAYVAM--TIVMPWIKAGTQF-----ITAWAHSSAIT--ISQAIGSRQMDEL 308
Cdd:cd13140 238 LPVA-----LQSIlfALISMI------LARIIASfgPVAIAAQKVGSQIesiswMTAEGFSTALAafVGQNYGAGKYDRI 306
|
330 340
....*....|....*....|....*.
gi 1159780652 309 RKNVDISIDMAVMISFVSAAFFLALS 334
Cdd:cd13140 307 RKGYKTALKIASAIGLFATLLLFFFG 332
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-421 |
3.35e-23 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 101.38 E-value: 3.35e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSP-LGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWA 89
Cdd:cd13138 6 LLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKKAVGT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 90 GLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPV 169
Cdd:cd13138 86 LLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVIIACVL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 170 NMAMSYVLIHGLagfeGIGVQGAAAGSLIA--ITIRLSYLTLCIKlDDSIVLSTKNLdaSLKRNTLnhfKEIFPVAANVT 247
Cdd:cd13138 166 NIILDLLFIAVF----HMGVAGAALATVIAqaISVLLALYYLRKK-KLPFKLSLKDF--RFDKEIL---KEILKIGLPSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 248 MLQTGATIYMLL-------YSQLTLNAYVA----MTIVMpwikagtQFITAWAHSSAITISQAIGSRQMDELRKNVDISI 316
Cdd:cd13138 236 LQQSLVSISFLIinsivnsYGVVASAAYGIankiNSFAF-------LPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 317 DMAVMISFVSAAFFLALSFVLPDLY---PDLDPTTYVALASIAPLYILLPIVRGYNTvhghVLRALGKTTEVFKINFTGQ 393
Cdd:cd13138 309 IISLIIGLIIILLVFFFAPQLLGLFtsdPEVIEIGAEYLRIYSIDYILFGILFVFNG----LFRGLGKTKFPMIISILRL 384
|
410 420
....*....|....*....|....*...
gi 1159780652 394 WIVSIPLCALIILHWDLSFFWAFAVMPF 421
Cdd:cd13138 385 WLVRIPLAYLLSRLTGLGLFGIWLAMPI 412
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
16-351 |
1.49e-19 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 89.23 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 16 PLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAGLIINV 95
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 96 LVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVNMAMSY 175
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 176 VLIHGLAGFegIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKNLDASLKRNTLNHFKEIFPVAANVTMLQTGATI 255
Cdd:TIGR00797 161 ILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 256 YMLLYSQLTLNAYVAMTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELRKNVDISIDMAVMISFVSAAFFLALSF 335
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330
....*....|....*.
gi 1159780652 336 VLPDLYPDLDPTTYVA 351
Cdd:TIGR00797 319 FIARLFTNDPEVLELA 334
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
16-176 |
4.84e-19 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 83.77 E-value: 4.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 16 PLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAGLIINV 95
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 96 LVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVNMAMSY 175
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 1159780652 176 V 176
Cdd:pfam01554 161 L 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-410 |
9.08e-19 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 88.12 E-value: 9.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAG 90
Cdd:cd13135 4 NHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAISS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 91 LIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVN 170
Cdd:cd13135 84 IVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLLN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 171 MAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYL-TLCIK---------LDDSIVLSTKNLDASLKRNTLNHFKEIF 240
Cdd:cd13135 164 VILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILvYLCRKikkltfklsNTKVLKANIRPYKFTIKLGLPLGGEEFL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 241 PVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPwikagtqfITAWAHSSAITISQAIGSRQMDELRKNVDISIDMAV 320
Cdd:cd13135 244 WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMP--------MYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGL 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 321 MISFVSAAFFLALSFVLPDLYpdldpTTYVALASIAPLYILLPIV----RGYNTVHGHVLRALGKTTEVFKINFTGQ-WI 395
Cdd:cd13135 316 LIYIAAAIVFLAFPYKILSLF-----TNDPELINYSIPYLIFIIIilffKSINIVYGFAIRAIGDTKWMLYTQIIGTiIV 390
|
410
....*....|....*
gi 1159780652 396 VSIPLCALIILHWDL 410
Cdd:cd13135 391 VSVALLLIFVFKLGL 405
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-418 |
4.90e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 86.09 E-value: 4.90e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQH 80
Cdd:cd13142 4 ILEGSILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDY 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 81 LSLNKG----FWAGLIINVLVAVLFWILITAFDKALISKLTDnvaLYAETERYLAVAKFIIIFNAITQVMIALFNALGRT 156
Cdd:cd13142 84 DKANKVagqtFSFVIILSLILAVLGYILSRPLLLLLIGAPEE---VYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 157 KVPFKGYLIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLtlciklddSIVLSTKNLDASLKRNTL--- 233
Cdd:cd13142 161 KTPMKIMFGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIG--------LYLLFKGRVGLKISLRDLkpd 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 234 -NHFKEIF----PVAANVTMLQTGATIYMLLYSQL---TLNAYVAMTIVMPWIkagtqFITAWAHSSAITI--SQAIGSR 303
Cdd:cd13142 233 wEWLKKIFriglPSSIEQSARALGFTVMTALVAGFgtvVVAAYGIGNRIISLV-----FLPAFGLARATSTmvGQNLGAG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 304 QMDELRKNVDIsidmAVMISFVSAAFFLALSFVLPDLYPDL---DPTTyVALASIAPLYILLPIV-RGYNTVHGHVLRAL 379
Cdd:cd13142 308 QIDRAEEIVKK----AALLIFLILVIGGVLAFLFAEPIVRVfinDPEV-IKEGADFLRIVAPSFPfFGLFQVINGAFRGS 382
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1159780652 380 GKTTEVFKINFTGQWIVSIPLCALIILHWDLSF---FWAFAV 418
Cdd:cd13142 383 GHTLTAMIISILRLWVIRIPLAYLLAYVLGLGVtgiWIAMAI 424
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
11-410 |
1.12e-16 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 81.85 E-value: 1.12e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIV-SFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWA 89
Cdd:cd13132 6 LRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFAnVTGFSILLGLASALDTLCGQAFGAKNYKLVGVYLQR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 90 GLIINVLVAVLFWILITAFDKALISkLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPV 169
Cdd:cd13132 86 ALVILLLCCVPISLLWLNTEPILLL-LGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVALLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 170 NMAMSYVLIHGLagfeGIGVQGAAagslIAITIrlSYLTLCIKLDDSIVLSTKNLDA--SLKRNTLNHFKEIFPVA-ANV 246
Cdd:cd13132 165 NILLNYLLVFVL----GLGFIGAA----LATSI--SYWLIVVLLLLYIFFSKGHKATwgGFSREAFRGWGPFLKLAiPSA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 247 TMLQTGATIYM-------LLYSQLTLNAY-VAMTIvmpwikAGTQFITAWAHSSAIT--ISQAIGSRQMDELRKNVDISI 316
Cdd:cd13132 235 LMLCLEWWAFEilvllagLLPGTVALAAQsICLTT------TSLLYMIPLGISIAASvrVGNELGAGNPKRAKLAAIVAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 317 DMAVMISFVSAAFFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIV 396
Cdd:cd13132 309 ILSLVIGVVVAILLLVLRDVWAYLFTS-DEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVNLVAYYLI 387
|
410
....*....|....
gi 1159780652 397 SIPLCALIILHWDL 410
Cdd:cd13132 388 GLPVGLLLAFVLGL 401
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-428 |
4.27e-16 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 79.86 E-value: 4.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPL-GEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWA 89
Cdd:cd13143 7 LKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKANRIFST 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 90 GLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPV 169
Cdd:cd13143 87 ALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 170 NMAMSYVLIHGLagfeGIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKNLDASLKRNTLNHFKEIFPVAANVTML 249
Cdd:cd13143 167 NIILDPLFIFVL----GLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSFLMQLSS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 250 QTGATIYMLLYSQLTLNAYV-AMTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELRKNVDISIDMAVMISFVSAA 328
Cdd:cd13143 243 SVVTIVLNLTLLGYGGDIGVaAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLFL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 329 FFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIVRGYNTVHGHVLRALGKTTEVFKINFTGQWIVSIPLcaLIILHW 408
Cdd:cd13143 323 ILLLFPEQIVSLFTD-DPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPL--LLILPR 399
|
410 420
....*....|....*....|
gi 1159780652 409 DLSFFWAFAVMPFEEIVKAL 428
Cdd:cd13143 400 LFGLDGIWLAFPLAEILTLL 419
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-414 |
1.39e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 78.43 E-value: 1.39e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQH 80
Cdd:cd13144 1 MGSGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 81 LSLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPF 160
Cdd:cd13144 81 KEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 161 KGYLIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVlstkNLDASLKRNTLNHFKEIF 240
Cdd:cd13144 161 IAQLIGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDV----QPDLRLFRPSLRIIKEIY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 241 PVAANVTMLQTGATIYM-LLYSQLTLNAYVAMTIVMPWIKAGT-QFITAWAHSSAIT--ISQAIGSRQMDELRKNVDISI 316
Cdd:cd13144 237 AVGLPSIIMQAISSVMVfGLNKILAGFGPTAVAVFGIYFKLQSfVFMPVFGLNNGLIpiVAYNYGAGNKDRIREAIKYAI 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 317 DMAVMI-SFVSAAFFLALSFVLPDLYPDLDPTTY--VALASIAPLYILLPIVrgynTVHGHVLRALGKTTEVFKINFTGQ 393
Cdd:cd13144 317 LIAVVImLAGGLLFQLFPDQLLGLFNASEEMLAIgvPALRIISLSFLFAALS----IILSGLFQALGRGVYSLIISVARQ 392
|
410 420
....*....|....*....|.
gi 1159780652 394 WIVSIPLCALIILHWDLSFFW 414
Cdd:cd13144 393 LVVLLPLAWLLAKMFGLNGVW 413
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
7-212 |
3.41e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 77.11 E-value: 3.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQ-SMLMIdTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNK 85
Cdd:cd13138 224 LKEILKIGLPSALQQSLVSiSFLII-NSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKK 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPF----- 160
Cdd:cd13138 303 GLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMiisil 382
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1159780652 161 KGYLIELPVNMAMSYVLIHGLagfEGIGVqGAAAGSLIAITIRLSYLTLCIK 212
Cdd:cd13138 383 RLWLVRIPLAYLLSRLTGLGL---FGIWL-AMPISNILSAIICIIYYRKGRW 430
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-161 |
2.75e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 74.46 E-value: 2.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 3 SQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQ--- 79
Cdd:cd13134 223 PKKLLKKILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDfde 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 80 -HLSLNKGFWAGLIINVLVAVLFWIlitaFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKV 158
Cdd:cd13134 303 aYKRVLKSLKIGLLVSLAVALLLAL----FREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARF 378
|
...
gi 1159780652 159 PFK 161
Cdd:cd13134 379 PVL 381
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
3-401 |
1.75e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 68.87 E-value: 1.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 3 SQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLS 82
Cdd:cd13149 4 EGSIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 83 LNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKG 162
Cdd:cd13149 84 AKRLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 163 YLIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIA----ITIRLSYLTLCIKLDDSIVLSTKNLDASLKRntlnHFKE 238
Cdd:cd13149 164 MLGAALVNVILDPILIFGFGPIPGMGIAGAAIATVISralgLGAALYFLHYHHRLIDFSEPSLKALFRSWKD----ILSI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 239 IFPVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIvmpwikaGTQ-----FITAWAHSSAIT--ISQAIGSRQMDELRKN 311
Cdd:cd13149 240 GIPAALSNILTPLSAAFITALVATYGPAAVAAFGV-------ATRiesfaFIIVMALSSALGpfVGQNWGAGQYERVQEG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 312 VDISIDMAVMISFVSAAFFLALSFVLPDLY---PDLDPTTYVALASIAPLYILLPIVRGYNTvhghVLRALGKTTEVFKI 388
Cdd:cd13149 313 LKISLKFSLIYGAILGIVLALFAGWLASLFsaePEVIELITLYLLIVPIGYGGLGILIITSA----SFNALGKPLYSLGL 388
|
410
....*....|...
gi 1159780652 389 NFTGQWIVSIPLC 401
Cdd:cd13149 389 NLIRVFLLYIPLA 401
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
6-157 |
6.74e-12 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 67.15 E-value: 6.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 6 YIRKNLSLAWPLALNALLMQ-SMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLN 84
Cdd:cd13143 224 IIKEILALGFPSFLMQLSSSvVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVK 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1159780652 85 KGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTK 157
Cdd:cd13143 304 QALKLALIVALIYGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAK 376
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-258 |
7.42e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 66.91 E-value: 7.42e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALnALLMQSML-MIDTFLVSPLGEVSLAAMGIATTIVSFVlgiQM----ALANGSQLVLSRAV 75
Cdd:cd13148 5 LLTAPILPTLLRLALPNIL-ALLVQTLVgLAETYFVGQLGTDALAGVALVFPLLMLT---QMmsngAMGGGVSSAIARAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 76 GSGQHLSLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAV----AKFIIIFNAITqvmiALFN 151
Cdd:cd13148 81 GAGDRERAEALVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVlfsgAILIWLVNLLA----AALR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 152 ALGRTKVPFKGYLIELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSYLTLCIKLDDSIVlstkNLDASLKRN 231
Cdd:cd13148 157 GTGNMRVPALVTLVGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRSRL----RLRLRALRL 232
|
250 260
....*....|....*....|....*....
gi 1159780652 232 TLNHFKEIFPVA--ANVTMLQTGATIYML 258
Cdd:cd13148 233 ERRLFRDILRVGllAALSPLQTNLTVLLL 261
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
6-209 |
1.86e-11 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 65.61 E-value: 1.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 6 YIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNK 85
Cdd:cd13137 224 IIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLI 165
Cdd:cd13137 304 YGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLI 383
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1159780652 166 EL-PVNMAMSYVLIHGLagfeGIGVQGAAAGSLIAITIRLSYLTL 209
Cdd:cd13137 384 SMwLVRLPLAYLLGFVL----GLGLTGIWLAMFVDTIVRAILLLY 424
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
11-365 |
1.11e-10 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 63.35 E-value: 1.11e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVS-LAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWA 89
Cdd:cd13136 6 LALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLVR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 90 GLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPV 169
Cdd:cd13136 86 ALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNVV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 170 NMAMSYVLIHGLagfeGIGVQGAAAGSLIA-ITIRLSYLTLCIKLDDSIVLSTKNLDASLKRntlnhFKEIFPVAANVtM 248
Cdd:cd13136 166 NIVLDPLFVFGL----GWGVAGAALATVIAqYLGALLGLWLLRRRVRLLGKSLSRRLPSKAA-----LKRLFKLNRDI-F 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 249 LQTGATIYMLLY-----SQLTLNAYVAMTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELRKNVDISIDMAVMIS 323
Cdd:cd13136 236 IRTLALLAAFLFftalaARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLG 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1159780652 324 FVSAAFFLALSFVLPDLYPDlDPTTYVALASIAPLYILLPIV 365
Cdd:cd13136 316 VLLALLFFLGGEPIIRLFTD-DPAVLALAATYLPWLALLPPI 356
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-428 |
2.18e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 62.24 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNaLLMQSML-MIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVG----SGQHLSLNK 85
Cdd:cd13139 17 FLLAIPMVLE-MVMESLFaVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGekdpEGAGFAAVQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWIlitaFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLI 165
Cdd:cd13139 96 AILLGVALSLILSILGYF----FAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRSLWL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 166 ELPVNMAMSYVLIHGLAGFEGIGVQGAAAGSLIAITIRLSY-LTLCIKLDDSIVLSTKNL--DASLKRNTLNH-----FK 237
Cdd:cd13139 172 ANGLNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYqLYHLFKGKGRIQIRRRHLklDWAIIKKIIKIavggiLQ 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 238 EIFPVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPwikagtqfitAW--AHSSAITISQAIGSRQMDELRKNV--D 313
Cdd:cd13139 252 FLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLP----------AWglSNAAATLVGQNLGAGQPDRAEKSVwrA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 314 ISIDMAVMISfVSAAFFLALSFVLpDLYpdldpTTYVALASIAPLYI----LLPIVRGYNTVHGHVLRALGKTTEVFKIN 389
Cdd:cd13139 322 GKYNMVFLGI-VSLVFFLFAEPLV-SFF-----TTDPEVIAIAVEALriisLGYIFYGYGMVLSQAFNGAGDTKTPTLIN 394
|
410 420 430
....*....|....*....|....*....|....*....
gi 1159780652 390 FTGQWIVSIPLCALIILHWDLSFFWAFAVMPFEEIVKAL 428
Cdd:cd13139 395 LVGFWLFQIPLAYLLARHLNLGPKGVFIAIPIAETVLAI 433
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
7-400 |
2.37e-10 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 62.14 E-value: 2.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTI----VSFVLGIQMALANgsqlVLSRAVGSGQH-- 80
Cdd:PRK01766 11 ARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIwlpvILFGHGLLLALTP----IVAQLNGAGRRer 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 81 --LSLNKGFWAGLIINVLVAVLFWILITAFDKALisKLTDNVALYAEteRYLAVAKFIIIFNAITQVMIALFNALGRTKV 158
Cdd:PRK01766 87 iaHQVRQGLWLALFLSVLIMLVLYNAVPPILNMM--NLEPEVADIAV--GYLHALLWGIPAYLLYQVLRSFIDGLGKTKP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 159 PFKGYLIELPVNMAMSYVLIHGLAGFEGIGvqGAAAGSLIAITIRLSYLTLCIKLDDSIVLSTKNLDASLKRNTLNHFKE 238
Cdd:PRK01766 163 TMVIGFLGLLINIPLNYIFIYGKFGFPELG--GVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKPDWAVIKR 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 239 IF----PVAANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPWikAGTQFITAWAHSSAITI--SQAIGSRQMDELRKNV 312
Cdd:PRK01766 241 LLklglPIGLAIFFEVSLFAVVTLLVSPLGTVTVAAHQIALNF--SSLLFMLPLSLAMALTIrvGFELGAGRTLDARQYA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 313 DISIDMAVMISFVSAAFFLALSFVLPDLYPDlDPTTyVALASIAPLY-ILLPIVRGYNTVHGHVLRALGKTTEVFKINFT 391
Cdd:PRK01766 319 YIGLAVGLGMALLTAIFLVLFREQIALLYTD-DPEV-VALASHLLLFaALFQFSDAIQVIGSGALRGYKDTRVIFFITFI 396
|
....*....
gi 1159780652 392 GQWIVSIPL 400
Cdd:PRK01766 397 AYWVLGLPL 405
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
5-208 |
3.92e-10 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 61.36 E-value: 3.92e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 5 PYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLN 84
Cdd:cd13131 226 ARLKELLRLGLPIGLTIFFEVSLFAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADAR 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 85 KGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFK--- 161
Cdd:cd13131 306 RAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPFLlal 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 1159780652 162 -GY-LIELPVNMAMSYVLIHGLAGFeGIGVQGAAAGSLIAITIRLSYLT 208
Cdd:cd13131 386 iSYwGIGLPLGYLLAFTTGLGAFGV-WIGLIIGLALAAILLLWRFRRLQ 433
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
11-334 |
7.98e-10 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 60.63 E-value: 7.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAG 90
Cdd:cd13147 12 IKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 91 LIINVLVAVLFWILITAFDKALISKL--TDNVALYAETERYLAVAKFIIIFNaitQVMIALFNALGRTKVPFKGYLIELP 168
Cdd:cd13147 92 ILLGLIISIILTIVLLPFLEPILVLMgaGEVLDLAVDYGRIIFLGSIFLIFN---NVAYGILRGEGDTKRAMYAMVAGSI 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 169 VNMAMSYVLIHGLagfeGIGVQGAAAGSLIAITIRLSYLT--LCIKLDDSIVLSTKNLDASLKrntlnHFKEIFPV---- 242
Cdd:cd13147 169 LNIILDPIFIYTL----GLGIAGAAWATVISMLISSLVLLywFFVKKDTYVSLSLKNFKFDKK-----IVKDILKVgipa 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 243 -AANVTMLQTGATIYMLLYSQLTLNAYVAMTIVMPWIKAGTQFITAWAhSSAITIS-QAIGSRQMDELRKNVDISIDMAV 320
Cdd:cd13147 240 sLEQLIMSVLMIILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIA-TAVTSVTgAAYGARNYEKLKTAYNYSIKLGL 318
|
330
....*....|....
gi 1159780652 321 MISFVSAAFFLALS 334
Cdd:cd13147 319 IIELIIAILIFIFA 332
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
5-202 |
3.61e-09 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 58.62 E-value: 3.61e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 5 PYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGI-QMALANGSQLVLSRAVGSGQH--- 80
Cdd:COG0728 219 PGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGLfGVAIGTALLPRLSRAAAAGDLeef 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 81 -LSLNKGFWAGLIINVLVAVLFWIL---IT-------AFDkalisklTDNVALYAETERYLAVAkfiIIFNAITQVMIAL 149
Cdd:COG0728 299 rRTLSRGLRLVLLLTLPAAVGLIVLaepIVrllfergAFT-------AEDTALTALALAAYALG---LPAFALVKVLARA 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1159780652 150 FNALGRTKVPFKGYLIELPVNMAMSYVLIHGLagfegiGVQGAAAGSLIAITI 202
Cdd:COG0728 369 FYARQDTRTPVRIAVIAVVVNIVLNLLLVPPL------GHAGLALATSLSALV 415
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
5-212 |
4.49e-09 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 58.23 E-value: 4.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 5 PYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGI-QMALANGSQLVLSRAVGSGQHLSL 83
Cdd:cd13123 212 PGVRRVLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQLPLGIfGVAIATALLPRLSRLAAAGDLDEF 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 84 NKGFWAGLIINVLVAVLFWILITAFDKALISKL-------TDNVALYAETERYLAVAkfiIIFNAITQVMIALFNALGRT 156
Cdd:cd13123 292 RRTLSRGLRLVLFLLLPAAVGLIVLAEPIVRLLfergaftAEDTLMTASALAAYALG---LPAFALVKLLSRAFYALKDT 368
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1159780652 157 KVPFKGYLIELPVNMAMSYVLIHGLagfegiGVQGAAAGSLIAITIRLSYLTLCIK 212
Cdd:cd13123 369 KTPVKIAVIAVAVNILLNLLLIKPL------GHVGLALATSLSAWVNALLLLVLLR 418
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
11-207 |
8.70e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 56.88 E-value: 8.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSP-LGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWA 89
Cdd:COG2244 176 LKYSLPLLLSGLLGLLLTNLDRLLLGAlLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRK 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 90 GLIINVLVAVLFWILITAFDKALISKLTDNValYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPV 169
Cdd:COG2244 256 ALRLLLLLGLPLALGLALLAPPLLSLLFGPE--YAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVL 333
|
170 180 190
....*....|....*....|....*....|....*...
gi 1159780652 170 NMAMSYVLIHGLagfegiGVQGAAAGSLIAITIRLSYL 207
Cdd:COG2244 334 NLVLNLLLIPRY------GLVGAAIATLLSYLVLLLLL 365
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-342 |
6.36e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 54.71 E-value: 6.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGiATTIVSFVLGIQMALANGSQL----VLSRAVG 76
Cdd:cd13146 1 MFSGPISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDPALVG-GIGLVFPLGMIFLALGNGIQVgvssLLARAIG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 77 SGQHLSLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRT 156
Cdd:cd13146 80 AQRAKELDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 157 KVPFKGYLIELPVNMAMSYVLIHGLagfeGIGVQGAAAGSLIAITIRLSYLTLCIKLDDS---IVLSTKNLDASLkrntl 233
Cdd:cd13146 160 KYMMMAMLIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAISLLYLLYVFLIGKSnvtIHIKLSNISSSV----- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 234 nhFKEIFPVAANVTMLQTGATIYMLLYSQLTL----NAYVAMTIVMPWIKAGTQFITAWAHSSAITISQAIGSRQMDELR 309
Cdd:cd13146 231 --IVEILRVGLPQMLLQLISSISFLIYNRIIIdidpVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRML 308
|
330 340 350
....*....|....*....|....*....|...
gi 1159780652 310 KNVDISIDMAVMISFVsaaFFLALSFVLPDLYP 342
Cdd:cd13146 309 QILMTAVILGIVVVLV---LVLGYVLVAPWLFS 338
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
1-202 |
1.01e-07 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 54.01 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPL-------GEVSLAAMGI----ATTIVSFVLGIQMALANGSQL 69
Cdd:COG5841 226 ESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRlqaaglsASEATSLYGIlsgmAQPLVNLPTVLATALATSLVP 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 70 VLSRAVGSGQHLSL----NKGFWAGLIINVLVAVLFWILITAFdkaliskltdNVALYAETE--RYLAVAKFIIIFNAIT 143
Cdd:COG5841 306 AISEAFAKKDRKLVrrriNQALRLTLLIGLPAAVGLAVLAEPI----------NTLLFGNPEggGILAILAPSAIFLSLQ 375
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 1159780652 144 QVMIALFNALGRTKVPFKGYLIELPVNMAMSYVLIHGLagfegiGVQGAAAGSLIAITI 202
Cdd:COG5841 376 QVTTGILQGLGKQKIPVINLLIGLLVKIILNYLLVPLF------GIYGAALATVIGYLV 428
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
1-212 |
1.35e-07 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 53.63 E-value: 1.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 1 MSSQPYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPL----GEVSLAAM-------GIATTIVSFVLGIQMALANGSQL 69
Cdd:cd13124 217 ISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRlqaaGLSESEATalygiltGRAQPLVQLPTVIATALSTSLVP 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 70 VLSRAVGSGQHLSLNKGFWAGLIINVLVAVLFWILITAFDKALiskltdNVALYAETE--RYLAVAKFIIIFNAITQVMI 147
Cdd:cd13124 297 AISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPI------NTLLFGDSEggLILQILAPSILFLSLQQVTA 370
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1159780652 148 ALFNALGRTKVPFKGYLIELPVNMAMSYVLIHGLagfegiGVQGAAAGSLIAITIRLSYLTLCIK 212
Cdd:cd13124 371 AILQGLGKVKIPVINLLIGLLVKIVLNYVLIPIF------GIYGAAIATVIGFLVAALLNLRALK 429
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
6-187 |
2.13e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 52.91 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 6 YIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSfvlgIQMALANGSQLVLSRAV----GSGQHL 81
Cdd:cd13140 229 YIKEILKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIES----ISWMTAEGFSTALAAFVgqnyGAGKYD 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 82 SLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFk 161
Cdd:cd13140 305 RIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPA- 383
|
170 180
....*....|....*....|....*....
gi 1159780652 162 gyLIELPVNMA---MSYVLIHGLAGFEGI 187
Cdd:cd13140 384 --IISIVFNGLripLALLLSPTGLGLNGI 410
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
13-199 |
8.22e-07 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 51.27 E-value: 8.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 13 LAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAGLI 92
Cdd:PRK10189 34 LAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 93 INVLVAVLFWILITAFDKALIskltDNVALYAETE------RYLAVAKFIIIFNAITQVMIALFNALGRTKVPFkgyLIE 166
Cdd:PRK10189 114 IMTLFAVLLAVLIHFFGEQII----DLVAGDATPEvkalalTYLELTVWSYPAAAITLIGSGALRGAGNTKIPL---LIN 186
|
170 180 190
....*....|....*....|....*....|....*.
gi 1159780652 167 LPVNM---AMSYVLIHGLAGFEGIGVQGAAAGSLIA 199
Cdd:PRK10189 187 GGMNIlniIISSILIYGLFSWQGLGFVGAGLGLTIS 222
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-202 |
1.94e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 50.01 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAG 90
Cdd:cd13141 14 ISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 91 LIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLIELPVN 170
Cdd:cd13141 94 LLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQILAVLLN 173
|
170 180 190
....*....|....*....|....*....|..
gi 1159780652 171 MAMSYVLIHGLAGFEGIGVQGAAAGSLIAITI 202
Cdd:cd13141 174 IILAPILITGWGTGRALGVAGAGLASSISVAI 205
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
7-130 |
2.05e-06 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 49.55 E-value: 2.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKG 86
Cdd:TIGR00797 215 LKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEV 294
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1159780652 87 FWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYL 130
Cdd:TIGR00797 295 ARVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYL 338
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
5-200 |
6.61e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 48.38 E-value: 6.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 5 PYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLN 84
Cdd:cd13139 236 AIIKKIIKIAVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAE 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 85 KGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVP----- 159
Cdd:cd13139 316 KSVWRAGKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPtlinl 395
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1159780652 160 FKGYLIELPvnmaMSYVLIHGLA-GFEGIGVQGAAAGSLIAI 200
Cdd:cd13139 396 VGFWLFQIP----LAYLLARHLNlGPKGVFIAIPIAETVLAI 433
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
11-199 |
8.79e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 47.68 E-value: 8.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAG 90
Cdd:cd13149 237 LSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKIS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 91 LIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPF-----KGYLI 165
Cdd:cd13149 317 LKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLglnliRVFLL 396
|
170 180 190
....*....|....*....|....*....|....
gi 1159780652 166 ELPvnmaMSYVLIHgLAGFEGIgVQGAAAGSLIA 199
Cdd:cd13149 397 YIP----LAYVGSH-LLGFAGV-FIGALAGNLIA 424
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
5-200 |
1.21e-05 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 47.70 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 5 PYIRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGI-QMALANGSQLVLSRAVGSGQHLSL 83
Cdd:TIGR01695 220 PGLKRFLKLFLPTTLGSSASQITLLINTALASFLEIGSVSALYYANRIYQLPLGIfGISLSTVLLPKLSRHASEGNWNEL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 84 NKGFWAGLIINVLVAVLFWILITAFDKALISKLTDNVALYAETERYLAVAKFI----IIFNAITQVMIALFNALGRTKVP 159
Cdd:TIGR01695 300 RDLLNQGIRLSLLLTIPSSFGLLILSIPIVSLLFERGAFSEEDTVMTATILAAyglgLIFYSLQKVLLRAFYARKDTRTP 379
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1159780652 160 FKGYLIELPVNMAMSYVLIhGLAGFEGIGVQGAAAGSLIAI 200
Cdd:TIGR01695 380 FINSVISVVLNALLSLLLI-FPLGLVGIALATSAASMVSSV 419
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
7-212 |
1.22e-05 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 47.15 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQSMLMIDTFLVSP-LGEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGqHLSLNK 85
Cdd:cd13128 205 AKELLRFSIPLALSGIFSLIYTRIDTIMLGYfLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELYKND-KDELKK 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWILITAFDKALISKLTDNValYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVPFKGYLI 165
Cdd:cd13128 284 LLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEE--YLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI 361
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1159780652 166 ELPVNMAMSYVLIHglagfeGIGVQGAAAGSLIAITIRLSYLTLCIK 212
Cdd:cd13128 362 GALLNVILNLLLIP------KYGIIGAAIATLISEFIIFILLLYLLK 402
|
|
| MurJ |
pfam03023 |
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of ... |
7-212 |
1.92e-04 |
|
Lipid II flippase MurJ; Peptidoglycan synthesis (PG) biosynthesis involves the formation of peptidoglycan precursor lipid II (undecaprenyl-pyrophosphate-linked N-acetyl glucosamine-N-acetyl muramic acid-pentapeptide) on the cytosolic face of the cell membrane. Lipid II is then translocated across the membrane and its glycopeptide moiety becomes incorporated into the growing cell wall mesh. MviN, renamed as MurJ, is a lipid II flippase essential for cell wall peptidoglycan synthesis. MurJ belongs to the MVF (mouse virulence factor) family of MOP superfamily transporters, which also includes the MATE (multidrug and toxic compound extrusion) transporter and eukaryotic OLF (oligosaccharidyl-lipid flippase) families. In addition to the canonical MOP transporter core consisting of 12 transmembrane helices (TMs), MurJ has two additional C-terminal TMs (13 and 14) of unknown function. Structural analysis indicates that the N lobe (TMs 1-6) and C lobe (TMs 7-14) are arranged in an inward-facing N-shape conformation, rather than the outward-facing V-shape conformation observed in all existing MATE transporter structures. Furthermore, a hydrophobic groove is formed by two C-terminal transmembrane helices, which leads into a large central cavity that is mostly cationic. Mutagenesis studies, revealed a solvent-exposed cavity that is essential for function. Mutation of conserved residues (Ser17, Arg18, Arg24, Arg52, and Arg255) at the proximal site failed to complement MurJ function, consistent with the idea that these residues are important for recognizing the diphosphate and/or sugar moieties of lipid II. It has also been suggested that the chloride ion in the central cavity and a zinc ion at the beginning of TM 7 might be functionally important.
Pssm-ID: 397249 [Multi-domain] Cd Length: 451 Bit Score: 43.43 E-value: 1.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 7 IRKNLSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFVLGI-QMALANGSQLVLSRAVGSGQHLSLNK 85
Cdd:pfam03023 196 LKRFLKLMLPTLLGVSVSQLNLLIDTFLASFLAPGSVSYLYYADRIYQLPLGIfGVSISTVLLPRLSRHAADGDWDEFRD 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 86 GFWAGLIINVLVAVLFWILITAFDKALISKL------TDNVALYaeTERYLAVAKFIIIFNAITQVMIALFNALGRTKVP 159
Cdd:pfam03023 276 LLDQAIRLTLLLMIPVSFGLLVLSIPIVSLLfergnfSPEDVTA--TAEVLAAYALGLIPYALVKLLSRVFYAREDTKTP 353
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1159780652 160 FKGYLIELPVNMAMSYVLIHGLagfegiGVQGAAAGSLIAITIRLSYLTLCIK 212
Cdd:pfam03023 354 FKISLISAVLNILLSLLLLPPL------GVAGLALATSLSSLIGLVFLYYILR 400
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
39-204 |
2.16e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 43.33 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 39 GEVSLAAMGIATTIVSFVLGIQMALANGSQLVLSRAVGSGQHLSLNKGFWAGLIINVLVAVLFWILITAFDKALISKLTD 118
Cdd:cd13132 256 GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTS 335
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 119 NVALYAETERYLAVAKFIIIFNAITQVMIALFNALGRTKVP-----FKGYLIELPVNMAMSYVLIHGLAGF-EGIGV-QG 191
Cdd:cd13132 336 DEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGayvnlVAYYLIGLPVGLLLAFVLGLGLKGLwIGLIAgLI 415
|
170
....*....|...
gi 1159780652 192 AAAGSLIAITIRL 204
Cdd:cd13132 416 LQAVILLLIILRT 428
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
11-415 |
3.48e-04 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 42.81 E-value: 3.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 11 LSLAWPLALNALLMQSMLMIDTFLVSPLGEVSLAAMGIATTIVSFV----LGIQMALANGSQLVLSRAVGSGQHLSLNKG 86
Cdd:PRK00187 13 LRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVsifcVGVIAAVGTLVAIRHGAGDIEGATRLAQAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 87 FWAGLIINVLVAVLFWILITAFdkALISKLTDNVALYAETERYLAVA-KFIIIFNAITqvmiALFNALGRTKVPFKGYLI 165
Cdd:PRK00187 93 LWLAWLLALVAALLLWNLKPLL--LLFGQAPQNVDAAMQFLHLLPFAlPGYLSFMALR----GFTSALGRAGPVMVISLA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 166 ELPVNMAMSYVLIHGLAGFEGIGVQGaaAGSLIAITIRLSYLTLCIKLDDSIVLSTKNLDASLKRNTLNHFKEIF----P 241
Cdd:PRK00187 167 GAVANLLLNYALIEGWFGLPKLGLMG--IGLVTALVSNGMALALALYIRRHPAYAAYPLRKGLSRPSRAALRELWrlglP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 242 V----AANVTMLqTGATIYMLLYSQLTLNAY-VAMTIVMpwikagTQFITAWAHSSAIT--ISQAIGSRQMDELRKNVDI 314
Cdd:PRK00187 245 IggtyAVEVGLF-TFAALCMGALGSTQLAAHqIALQIVS------VAFMVPVGLSYAVTmrVGQHYGAGRLLEARRAGRV 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1159780652 315 SIDMAVMISFVSAAFFLALSFVLPDLYPDL-DP------TTYVALASIAPLYILLPivrGYNTVHGHVLRALGKTTEVFK 387
Cdd:PRK00187 318 GIGFGAVVMLLFAGLFWLLPEAIIGLFLDRnDPafaeivQLAVSLLAVAAWFELFD---GTQTIAMGAIRGLKDARTTFL 394
|
410 420 430
....*....|....*....|....*....|
gi 1159780652 388 INFTGQWIVSIPLCAL--IILHWDLSFFWA 415
Cdd:PRK00187 395 IGLACYWLVGAPLAWLlaFTLGWGAVGVWW 424
|
|
| |
