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Conserved domains on  [gi|1160659316|ref|WP_079520581|]
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DUF535 family protein [Luteibacter sp. 22Crub2.1]

Protein Classification

VirK/YbjX family protein( domain architecture ID 10006834)

VirK/YbjX family protein is a DUF535 domain-containing protein; similar to Haemophilus influenzae protein HI_0461

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VirK COG2990
Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family ...
1-284 3.05e-72

Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family [Function unknown];


:

Pssm-ID: 442229  Cd Length: 307  Bit Score: 225.16  E-value: 3.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316   1 MQSIFRFARSLRGR-----SAWHRKRSHVVnavlnYVGRSVAHWREHDAWLAFL-ETPPMAGVSSIDTILTERYQHRYIS 74
Cdd:COG2990     1 MSNILQLFFSLPSGklypgKIWKKRRKRLK-----FLLRSLLHPRATKRLLDFLaQQPLLAALLKAQPRLPCKLHRPYLD 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  75 KAWNRERRLKVLREHYEFALARFPRTLFHVLYRERQVLLGKVLLRNGEALSLMLKAPFRRAREGEMTLSLVDHQGMQISY 154
Cdd:COG2990    76 KGFSAKQRLDAIVDHYRFLEQLLPSALLQALLSEKGLTLAELTGKEGEDFSLYLSSNPGLDKEGELTLELRDAEGQLLYS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316 155 AAFSFV--DGGKAIAIGCLQGAPNHAGLEAVRELTRQCHGLRPKNLLLSLIRSLAEAFEVERVLGISNEAHVFAGIA--- 229
Cdd:COG2990   156 LTFSLVqdNGKRTLFIGGLQGPKREVPHELIKQATKACHGLRPKRLLVEALCLLARVLGIEQILAVSNKGHIYRSLRyrl 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1160659316 230 ---DKVKADYNGFWRESGGQETSEGFYAMAPHEPVRCETEVESKRRSEFRRREALRHE 284
Cdd:COG2990   236 kksKKLHADYDEFWQELGGEPKDDGYFQLPLQIERKPLEEIASKKRAEYRKRYELLDE 293
 
Name Accession Description Interval E-value
VirK COG2990
Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family ...
1-284 3.05e-72

Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family [Function unknown];


Pssm-ID: 442229  Cd Length: 307  Bit Score: 225.16  E-value: 3.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316   1 MQSIFRFARSLRGR-----SAWHRKRSHVVnavlnYVGRSVAHWREHDAWLAFL-ETPPMAGVSSIDTILTERYQHRYIS 74
Cdd:COG2990     1 MSNILQLFFSLPSGklypgKIWKKRRKRLK-----FLLRSLLHPRATKRLLDFLaQQPLLAALLKAQPRLPCKLHRPYLD 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  75 KAWNRERRLKVLREHYEFALARFPRTLFHVLYRERQVLLGKVLLRNGEALSLMLKAPFRRAREGEMTLSLVDHQGMQISY 154
Cdd:COG2990    76 KGFSAKQRLDAIVDHYRFLEQLLPSALLQALLSEKGLTLAELTGKEGEDFSLYLSSNPGLDKEGELTLELRDAEGQLLYS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316 155 AAFSFV--DGGKAIAIGCLQGAPNHAGLEAVRELTRQCHGLRPKNLLLSLIRSLAEAFEVERVLGISNEAHVFAGIA--- 229
Cdd:COG2990   156 LTFSLVqdNGKRTLFIGGLQGPKREVPHELIKQATKACHGLRPKRLLVEALCLLARVLGIEQILAVSNKGHIYRSLRyrl 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1160659316 230 ---DKVKADYNGFWRESGGQETSEGFYAMAPHEPVRCETEVESKRRSEFRRREALRHE 284
Cdd:COG2990   236 kksKKLHADYDEFWQELGGEPKDDGYFQLPLQIERKPLEEIASKKRAEYRKRYELLDE 293
DUF535 pfam04393
Protein of unknown function (DUF535); Family member Shigella flexneri VirK is a virulence ...
17-281 7.72e-68

Protein of unknown function (DUF535); Family member Shigella flexneri VirK is a virulence protein required for the expression, or correct membrane localization of IcsA (VirG) on the bacterial cell surface,. This family also includes Pasteurella haemolytica lapB, which is thought to be membrane-associated.


Pssm-ID: 427919  Cd Length: 279  Bit Score: 212.85  E-value: 7.72e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  17 WHRKRSHVVnavlnYVGRSVAHWREHDAWLAFL-ETPPMAGVSSIDTILTERYQHRYISKAWNRERRLKVLREHYEFALA 95
Cdd:pfam04393   2 WRERKRRLK-----FLLRSLLHPRQTRRFLDFLnQHPLLKPLLKAQPRLPEKLHRPYLDKGLSAAQRLAAIVDHYDFLEQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  96 RFPRTLFHVLYRERQVLLGKVLLRNGEALSLMLKAPFRRAREGEMTLSLVDHQGMQISYAAFSFV--DGGKAIAIGCLQG 173
Cdd:pfam04393  77 KLSAELLQRLLSQEGLTLASLEGKEGEDFELYLSSNAGQPKEGELALELRDEDGQRLYSLTFTFLrrPGEPTLLIGGLQG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316 174 APNHAGLEAVRELTRQCHGLRPKNLLLSLIRSLAEAFEVERVLGISNEAHVFA-----GIADK-VKADYNGFWRESGGQE 247
Cdd:pfam04393 157 PKGENSHEIIKQATKACHGLRPKRLLVEALRALAQALGVEQILAVSNKGHVYRqlryrLRKKKkLLADYDEFWQELGGEP 236
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1160659316 248 TSEGFYAMAPHEPVRCETEVESKRRSEFRRREAL 281
Cdd:pfam04393 237 LDDGYYRLPLEIERKDLEEIPSKKRSMYRRRYAL 270
 
Name Accession Description Interval E-value
VirK COG2990
Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family ...
1-284 3.05e-72

Outer membrane protein VirK/YbjX involved in antimicrobial peptide resistance, DUF535 family [Function unknown];


Pssm-ID: 442229  Cd Length: 307  Bit Score: 225.16  E-value: 3.05e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316   1 MQSIFRFARSLRGR-----SAWHRKRSHVVnavlnYVGRSVAHWREHDAWLAFL-ETPPMAGVSSIDTILTERYQHRYIS 74
Cdd:COG2990     1 MSNILQLFFSLPSGklypgKIWKKRRKRLK-----FLLRSLLHPRATKRLLDFLaQQPLLAALLKAQPRLPCKLHRPYLD 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  75 KAWNRERRLKVLREHYEFALARFPRTLFHVLYRERQVLLGKVLLRNGEALSLMLKAPFRRAREGEMTLSLVDHQGMQISY 154
Cdd:COG2990    76 KGFSAKQRLDAIVDHYRFLEQLLPSALLQALLSEKGLTLAELTGKEGEDFSLYLSSNPGLDKEGELTLELRDAEGQLLYS 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316 155 AAFSFV--DGGKAIAIGCLQGAPNHAGLEAVRELTRQCHGLRPKNLLLSLIRSLAEAFEVERVLGISNEAHVFAGIA--- 229
Cdd:COG2990   156 LTFSLVqdNGKRTLFIGGLQGPKREVPHELIKQATKACHGLRPKRLLVEALCLLARVLGIEQILAVSNKGHIYRSLRyrl 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1160659316 230 ---DKVKADYNGFWRESGGQETSEGFYAMAPHEPVRCETEVESKRRSEFRRREALRHE 284
Cdd:COG2990   236 kksKKLHADYDEFWQELGGEPKDDGYFQLPLQIERKPLEEIASKKRAEYRKRYELLDE 293
DUF535 pfam04393
Protein of unknown function (DUF535); Family member Shigella flexneri VirK is a virulence ...
17-281 7.72e-68

Protein of unknown function (DUF535); Family member Shigella flexneri VirK is a virulence protein required for the expression, or correct membrane localization of IcsA (VirG) on the bacterial cell surface,. This family also includes Pasteurella haemolytica lapB, which is thought to be membrane-associated.


Pssm-ID: 427919  Cd Length: 279  Bit Score: 212.85  E-value: 7.72e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  17 WHRKRSHVVnavlnYVGRSVAHWREHDAWLAFL-ETPPMAGVSSIDTILTERYQHRYISKAWNRERRLKVLREHYEFALA 95
Cdd:pfam04393   2 WRERKRRLK-----FLLRSLLHPRQTRRFLDFLnQHPLLKPLLKAQPRLPEKLHRPYLDKGLSAAQRLAAIVDHYDFLEQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316  96 RFPRTLFHVLYRERQVLLGKVLLRNGEALSLMLKAPFRRAREGEMTLSLVDHQGMQISYAAFSFV--DGGKAIAIGCLQG 173
Cdd:pfam04393  77 KLSAELLQRLLSQEGLTLASLEGKEGEDFELYLSSNAGQPKEGELALELRDEDGQRLYSLTFTFLrrPGEPTLLIGGLQG 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1160659316 174 APNHAGLEAVRELTRQCHGLRPKNLLLSLIRSLAEAFEVERVLGISNEAHVFA-----GIADK-VKADYNGFWRESGGQE 247
Cdd:pfam04393 157 PKGENSHEIIKQATKACHGLRPKRLLVEALRALAQALGVEQILAVSNKGHVYRqlryrLRKKKkLLADYDEFWQELGGEP 236
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1160659316 248 TSEGFYAMAPHEPVRCETEVESKRRSEFRRREAL 281
Cdd:pfam04393 237 LDDGYYRLPLEIERKDLEEIPSKKRSMYRRRYAL 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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