|
Name |
Accession |
Description |
Interval |
E-value |
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-410 |
1.04e-53 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 182.38 E-value: 1.04e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 11 KNKMTPYWIRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVP 90
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 91 GFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLS 170
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 171 LGfsWRITFFIFALLTIIVSIIMLFTIkndsknenlikrkidieekkfsssiklllmnrnlivsYIVAFCSLYGFSVMVT 250
Cdd:COG2271 161 FG--WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 251 WLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKI-MKFMLIFSSIFTFLIGFTNSTVWIIVGLVLY 329
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLvLAIGLLLAALALLLLALLPSPALAIALLFLA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 330 GFmGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYLASVFLLIGYFSLILIKE 409
Cdd:COG2271 282 GF-GLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLLR 359
|
.
gi 1169138901 410 K 410
Cdd:COG2271 360 E 360
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-407 |
5.68e-45 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 159.27 E-value: 5.68e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 18 WIRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 98 FLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRI 177
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW--LLLLFGWRW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 178 TFFIFALLTIIVSIIMLFTIkndsknenlikrkidieekkfsssiklllmnRNLIVSYIVAFCSLYGFSVMVTWLPYYLQ 257
Cdd:cd17319 159 AFIIEGLLGLLLAVLWWFYL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 258 TEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIF--SSIFTFLIGFTNSTVWIIVGLVLyGFMGKI 335
Cdd:cd17319 208 QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLllAAVGLLLAYLTTSPVVAVILLSL-AGFGIG 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1169138901 336 AMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17319 287 AASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
20-372 |
1.03e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 147.81 E-value: 1.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 20 RLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFL 99
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITF 179
Cdd:COG2814 90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL--LADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 180 FIFALLTIIVSIIMLFTIKNDSKnenlikrkidIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTE 259
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 260 QGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdP 339
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLF-P 315
|
330 340 350
....*....|....*....|....*....|...
gi 1169138901 340 IIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLA 372
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
20-410 |
2.43e-37 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 139.63 E-value: 2.43e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 20 RLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFL 99
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITF 179
Cdd:COG2223 85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG--WRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 180 FIFALLTIIVSIIMLFTIKNDSKNENLikrkidiEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTE 259
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAA-------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 260 QGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDP 339
Cdd:COG2223 236 FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR-RVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169138901 340 IIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILIKEK 410
Cdd:COG2223 315 AVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-405 |
4.43e-34 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 130.62 E-value: 4.43e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 25 FFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGL 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 105 SEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFAL 184
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 185 LTIIVSIIMLFTIKndSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEG 264
Cdd:cd06174 161 LALLAAILLLLVVP--DPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 265 SIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPIIVAF 344
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLL-PLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169138901 345 VANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLI 405
Cdd:cd06174 318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
38-408 |
5.81e-34 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 130.00 E-value: 5.81e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMI 117
Cdd:cd17325 14 IIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 118 SGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFswRITFFIFALLTIIVSIIMLFTI 197
Cdd:cd17325 94 QGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGY--RAPFLVCAALALLALVLALLLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 198 KNDSKNENlikrKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALL 277
Cdd:cd17325 172 PEPRPPPN----KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 278 ALPGSILFSWINDRFQKhVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFmGKIAMDPIIVAFVANNAPQNLYSTT 357
Cdd:cd17325 248 SALSQPPAGKLSDRIGR-KPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGL-GLGLVFPATLALLADIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1169138901 358 FGLYNFIGMSSSVLAPYITGVLsIYTGSMKAGFYLASVFLLIGYFSLILIK 408
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFL-YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-373 |
1.26e-30 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 120.22 E-value: 1.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 24 VFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTG 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 104 LSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITFFIFA 183
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG--WRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 184 LLTIIVSIIMLFTIKNDSKNENLIKRkidiEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYlQTEQGIE 263
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPESKRPKPAE----EARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 264 GSIAGYLSSIIALLALPGSILFSWINDRFQKHVK--IMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPII 341
Cdd:pfam07690 234 ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVF-PAL 312
|
330 340 350
....*....|....*....|....*....|..
gi 1169138901 342 VAFVANNAPQNLYSTTFGLYNFIGMSSSVLAP 373
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-413 |
8.34e-28 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 113.41 E-value: 8.34e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 9 NKKNKMTPYWIRLVIVFFLGWIFiygnrAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVL 88
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFAT-----ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 89 VPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFygpQFALSSEsIPNKYRTIGSAIINSGGA---IGLSLG-FIFS 164
Cdd:COG0738 77 LLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL---DVAANPY-VAALGPETAASRLNLLHAffsLGALLGpLLGG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 165 SYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNEnlikrkiDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYG 244
Cdd:COG0738 153 LLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEE-------EEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 245 FSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIV 324
Cdd:COG0738 226 EGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGPWLALI 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 325 GLVLYGFmGKIAMDPIIVAFVANNAPQNLySTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSL 404
Cdd:COG0738 305 GLALVGL-GLSLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLAL 382
|
....*....
gi 1169138901 405 ILIKEKDAN 413
Cdd:COG0738 383 ALKRKRRKK 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
21-407 |
1.00e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 112.66 E-value: 1.00e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGWIFIYGNrAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLA 100
Cdd:cd17474 1 LYAVFFATLLAVLGV-SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 101 VTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLslgFSWRITFF 180
Cdd:cd17474 80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA---ISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 181 IFALLTIIVSIIMLFTIKNDSKNENLIKrkidieeKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQ 260
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEKAKSSS-------ATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 261 GIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPI 340
Cdd:cd17474 230 GISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNL-PL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1169138901 341 IVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17474 309 LTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
22-398 |
1.90e-25 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 106.48 E-value: 1.90e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAV 101
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 102 TGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITFFI 181
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG--WRAAFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 182 FALLTIIVSIIMLFTIKNDSKNENLikrkidieEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQG 261
Cdd:cd17324 159 IAVLALLAALLLWRLLPSLPPKKPG--------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 262 IEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMkFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkIAMDPII 341
Cdd:cd17324 231 FSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI-ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHSAL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1169138901 342 VAFVANNAPQNLySTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLL 398
Cdd:cd17324 309 QTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLL 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
26-379 |
2.15e-25 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 106.31 E-value: 2.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 26 FLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLS 105
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 106 EGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSyFTLSLGFSWRITFFIFALL 185
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVL-FGIAELYSWHWVFIVPGII 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 186 TIIVSIIMLFTIKNDSKNENLIK-------------RKIDIEEKKFSSSIKLLLMNRNLIVsyiVAFCSLYGFSV---MV 249
Cdd:TIGR00881 160 AIIVSLICFLLLRDSPQSCGLPPaeempneepdgdaEKKEEELTKKQIFLQYVLLNKVLWY---ISLGYVFVYVVrtgIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 250 TWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRF---QKHVKIMKFM-LIFSSIFTFLIGFTNSTVWIIVG 325
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMaLIIVSLLVYWLNPAANPLMDLIC 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1169138901 326 LVLYGFMGkiaMDPIIVAFVANN--APQNLYSTTFGLYNFIGMSSSVLAPYITGVL 379
Cdd:TIGR00881 317 LFALGFLV---YGPQMLIGVIASelAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
22-405 |
1.53e-24 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 103.45 E-value: 1.53e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTPVIGEIKSDYS--LNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFL 99
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFT--LSLGFSWRI 177
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIplLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 178 TFFIFALLTIIVsiimlftikndsknenlikrkidieekkfsssiklLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQ 257
Cdd:cd17316 161 LFLIGALPALLA-----------------------------------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 258 TEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIGF--TNSTVWIIVGLVLYGFMGKI 335
Cdd:cd17316 206 TVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-KTLVIGLILSGILALPLFYllSGSPTLLLLLLFILSFFVGG 284
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 336 AMdPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLI 405
Cdd:cd17316 285 VW-GALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-400 |
1.67e-24 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 104.24 E-value: 1.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAV 101
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 102 TGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfSWRITFFI 181
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG-GWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 182 FALLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQG 261
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 262 I----EGSIAGYLSSIIALLALPGSILFSWINDRFQKHVK-----IMKFMLIFSSIFTFL--IGFTNSTVWIIVGLVLYG 330
Cdd:cd17328 240 VgdlsSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFLalVLALSNLLLAWVLLFLGE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 331 FMGKIAMdPIIVAFVANNAPQNLYSTTFGLYNFIGMS-SSVLAPYITGVLSIYTG-----------SMKAGFYLASVFLL 398
Cdd:cd17328 320 FLLSLNW-APVFAILLYVVIPTRRSTASAIQILLSHLlGDAGSPYLIGLISDLLRqnkdsplaeaaSLQYALLLCSFVLV 398
|
..
gi 1169138901 399 IG 400
Cdd:cd17328 399 LG 400
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
46-400 |
1.47e-23 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 101.16 E-value: 1.47e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 46 IKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTF 125
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 126 YGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIFALLTIIVSIIMLFTIKnDSKNEN 205
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPP--LALHYGWRAAFVVAGLVSILAAVLFWLFYR-EPPAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 206 LIKRKidieEKKFSSSIKLLLMNRNLIVsyIVAFCSLYGFS--VMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSI 283
Cdd:cd17475 179 AATES----ASTLLRSLKEVLRNRDVWL--IAIAGALLVAPqfALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRI 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 284 LFSWINDRF--QKHVKIMKFMLIFSSIFTFLIGF--TNSTVWIIVGLV-LYGFMGkIAMDPIIVAFVANNAPQNLYSTTF 358
Cdd:cd17475 253 GLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLlsPGTPLWLLVLLLiLLGLFA-IGWNGLYLTLVAESAGPEQAGTAL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1169138901 359 GLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIG 400
Cdd:cd17475 332 GLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-400 |
4.15e-23 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 99.55 E-value: 4.15e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFYgPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFswrITFFIFALLTIIVSIIMLFt 196
Cdd:cd17478 93 LAGIGSAAFH-PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG---LGLLILLIIPGLAVALLLL- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 197 ikndsKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLqTEQGIEGSIAGYLSSIIAL 276
Cdd:cd17478 168 -----RLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 277 LALPGSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIGFTNStVWIIVGLVLYGFMGKIAMdPIIVAFVANNAPQNLyST 356
Cdd:cd17478 242 AGAIGTLIGGPLSDRF-GRRRVIIASLLLAAPFLLLFLLTPG-IWSYILLVLAGFLLFASF-PVTVVLAQELLPGNV-GL 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1169138901 357 TFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYLASVFLLIG 400
Cdd:cd17478 318 ASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLG 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
39-400 |
1.09e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 98.79 E-value: 1.09e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 39 LTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMIS 118
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 119 GIGQGTFYGPQFALSSESIPNKyrtigSAIINSGGAIGLSLGFIFSSYFT--LSLGFSWRITFFIFALLTIIVSIIMLft 196
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWFPDR-----VGLMTGLYTAAMGLGAALAAGLTvpLAAALGWRGALAVWALLALLALLLWL-- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 197 ikndsknenLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLY--GFSVMVTWLPYYLQtEQGIEGSIAGYLSSII 274
Cdd:COG2807 190 ---------PLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQslLYYAVVAWLPPILR-DAGLSAATAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 275 ALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTnSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAP-QNL 353
Cdd:COG2807 260 QLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLA-PGSLPWLWAVLLGLGQGGLF-PLALTLIGLRARtPAE 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1169138901 354 YSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIG 400
Cdd:COG2807 338 AAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLM 384
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
19-407 |
5.69e-22 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 96.19 E-value: 5.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIF 98
Cdd:cd17312 2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 99 LAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRIT 178
Cdd:cd17312 82 NIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAAS--LASYYGWRAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 179 FFIFALLTIIVSIIMLFTIKNDSKnenlikrkidieekkfsssiklllmnrnliVSYIVAFCSLYGFSV---MVTWLPYY 255
Cdd:cd17312 160 FLVPGIVGLVVAIILFFFLRDSPP------------------------------YVWVLSLAYAFVYIVryaCLDWGPLY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 256 LQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRF--QKHVKIMKFMLIFSSIFTFLIGFT-NSTVWIIVGLVLYGFM 332
Cdd:cd17312 210 LYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFpHNKLLSIVLLFLIGFF 289
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1169138901 333 --GKIAMDPIIVAfvANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17312 290 vgGPINLIGGAAA--QDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
11-379 |
2.13e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 95.12 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 11 KNKMTPYWIRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVP 90
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 91 GFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLS 170
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW--LI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 171 LGFSWRITFFIFALLTIIVSIIML--------FTIKNDSKNENLIKRKIDI---------------EEKKFSSSIKLLL- 226
Cdd:TIGR00895 166 PVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETVRRIVNAIAPqmqaeaqsalpeqksTQGTKRSVFKALFq 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 227 --MNRNLIVSYIVAFCSLYGFSVMVTWLPyYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQkhVKIMKFMLI 304
Cdd:TIGR00895 246 gkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLG--PRVTALLLL 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169138901 305 FSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVL 379
Cdd:TIGR00895 323 LGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
22-400 |
4.14e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 93.77 E-value: 4.14e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAV 101
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 102 TGL--SEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITF 179
Cdd:cd17380 81 TPLlaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPL--LLEYYGWPSVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 180 FIFALLTIIVSIIMLFtikndsknenlikrkidieekkfsssiklllMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTE 259
Cdd:cd17380 159 YFFGLLGLLWALVWLI-------------------------------YLPPVWAIIVAHFCMNWGFYILLSWLPTYFHEV 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 260 QGIEGSiAGYLSSIIALLALPGSILFSWINDRFQKH-------VKIMKFM-LIFSSIFTFLIGFTNS----TVWIIVGLV 327
Cdd:cd17380 208 LVPLAK-GWVFNVVPWLVMFPSSNVAGWLADHLISRgwtvtsvRKLMQSIgFLGPALFLLLLSHTDSfslaLLCMSVALG 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169138901 328 LYGF-MGKIAMDPIIVAfvANNApqnlySTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIG 400
Cdd:cd17380 287 LSAFsSSGVLVNHQDIA--PNYA-----GIVFGISNTAGTIPGIVGVYLTGYILEATGSWSLVFVLAAVVNLVG 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-400 |
9.80e-21 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 92.66 E-value: 9.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGWIFIYgnraILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLA 100
Cdd:cd17489 1 ILLANFFFFLSFY----LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 101 VTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWritFF 180
Cdd:cd17489 77 LYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV---LF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 181 IFALLTIIVSIIMLFTIKNDSknenlikrKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQtEQ 260
Cdd:cd17489 154 IVAAVLALLALLLVFLVKDPP--------PVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAA-ER 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 261 GIegSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFsSIFTFLIGFTNSTVWIIVGLVLYGfMGKIAMDPI 340
Cdd:cd17489 225 GI--SNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLL-ALGLLLLSFAGSPWMLLLAAVLYG-LGFGLLFPA 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 341 IVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYLASVFLLIG 400
Cdd:cd17489 301 LQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLA 359
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
70-384 |
8.74e-20 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 90.73 E-value: 8.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 70 IVQIPSGYLGDMYSKKW--------VLVPGFLISGIFLAVT---GLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIP 138
Cdd:COG2211 61 ITDPLIGALSDRTRTRWgrrrpwilIGAIPLALSFVLLFTApdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 139 N-KYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLG----FSWRITFFIFALLTIIVSIIMLFTIKNDSKNENlikrkidi 213
Cdd:COG2211 141 DyEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaaLGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 214 EEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQ 293
Cdd:COG2211 213 EKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 294 KHvKIMKFMLIFSSIFTFLIGF--TNSTVWIIVGLVLYGFmGKIAMDPIIVAFVANNAPQNLYST-------TFGLYNFI 364
Cdd:COG2211 293 KK-KAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGI-GLGAILVLPWAMLADVVDYDEWKTgrrreglYFGIFTFA 370
|
330 340
....*....|....*....|
gi 1169138901 365 GMSSSVLAPYITGVLSIYTG 384
Cdd:COG2211 371 IKLGQALAGALAGLLLALFG 390
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-407 |
2.01e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 89.25 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 18 WIRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI 97
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 98 FLAVTGLSEGYLLLISAW-MISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGlslGFIFSSYFTLSLG-FSW 175
Cdd:cd17355 81 GLVLLALATSLWQLYLLWgLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLG---SLVFLPLGAALIEaFGW 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 176 RITFFIFALLTIIVSIIMLFTIKNDSKNENLiKRKIDIEEKKFSSSIKLLLMNRN-LIVSYIVAFCSLYGFSVMVTWLPY 254
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLLRRRPADLAL-RAYDDASPASPGSTLKEALRSASfWLLALAFFLCGFAVVGLIVHLVPY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 255 YlqTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGk 334
Cdd:cd17355 237 L--ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGW- 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169138901 335 IAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17355 314 GATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
49-401 |
9.69e-18 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 84.21 E-value: 9.69e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 49 DYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSE--GYLLLISAWMISGIGQGTFY 126
Cdd:cd17318 50 EFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 127 GPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITFFIFALLTIIVSIIMLFTIkndsknenl 206
Cdd:cd17318 130 PAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG--WPSIFYIFGGLGLLWCLLWFFLV--------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 207 ikrkidieekkfsssiklllmnRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFS 286
Cdd:cd17318 199 ----------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 287 WIND--RFQKHV------KIMKFM-LIFSSIFTFLIGFTNST-VWIIVGLVLYGFMGKIAMDPIIVAFVaNNAPqNLYST 356
Cdd:cd17318 257 YLADwlRSRGILstttvrKLFTSIgFLGPGVFLIALGYLGSNaTLAVVFLTLSVGLSGACYSGFLVNHL-DLAP-NYAGT 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1169138901 357 TFGLYNFIGMSSSVLAPYITGVLsIYTGSMKAG----FYLASVFLLIGY 401
Cdd:cd17318 335 LMGITNTAATIAGIISPLIVGAI-VKNDQTIGQwrivFFISAAIYILGA 382
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-406 |
3.26e-17 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 82.66 E-value: 3.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 57 IGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI------FLAVTGLSEGYLLLISAwMISGIGQGTFYGPQF 130
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALlaavlaLLALLGSLSLWLLLVLA-FLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 131 ALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWritFFIFALLTIIVSIIMLFTIKNDSKNENliKRK 210
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGG---AFAINALSFLLSALLLLFIRRPPPAAP--GES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 211 IDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWIND 290
Cdd:cd06173 190 SSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSK 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 291 RFqKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSV 370
Cdd:cd06173 270 RR-RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAG-GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMP 347
|
330 340 350
....*....|....*....|....*....|....*.
gi 1169138901 371 LAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLIL 406
Cdd:cd06173 348 LGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
19-195 |
2.49e-16 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 79.08 E-value: 2.49e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIF 98
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 99 LAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRIT 178
Cdd:COG0477 93 SLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG--WRWI 170
|
170
....*....|....*..
gi 1169138901 179 FFIFALLTIIVSIIMLF 195
Cdd:COG0477 171 FLINAPLGLLALVLRLR 187
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
37-400 |
4.74e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 79.15 E-value: 4.74e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAE-IGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAW 115
Cdd:cd17473 16 AAIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 116 MISGIGQGTFYGPQFALSSESIPNKYRT----IGSAIINSGGAIGLSLGFIFSSyftlslgFSWRITFFIFaLLTIIVSI 191
Cdd:cd17473 96 ALLGIGVAGIMTLATALIGDYFEGEERAkmlgLQSAAMSLGGVVFLLLGGALAE-------IGWRAPFLVY-LLALPVLI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 192 IMLFTIKNdsknenliKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLS 271
Cdd:cd17473 168 LVLLFLPE--------PARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 272 SIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAP- 350
Cdd:cd17473 240 AIASLAGAIGALLFGRLKRRL-GKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLL-PTLNSWAMSLVPp 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1169138901 351 --QNLYSTTFGLYNFIGMSSSvlaPYITGVLSIYTGSMKAGFYLASVFLLIG 400
Cdd:cd17473 318 elRGRAMGIVTSAFFLGQFLS---PLVLGPLVNLTGGLSGAFLILGVLALVL 366
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-400 |
1.23e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 77.63 E-value: 1.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITFFIFALLTIIVSIIMLFT 196
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG--WRSVFLLGGVPPLILLPLLRGT 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 197 ikndsknenlikrkidieekkfsssikLLLmnrnlivsYIVAFCSLYGFSVMVTWLPYYLQtEQGIEGSIAGYLSSIIAL 276
Cdd:cd17365 174 ---------------------------LLL--------WVTFFMGLLLVYLLNSWLPKLMV-EAGYSLSQALTITLLLNI 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 277 LALPGSILFSWINDRFQKHVKIMKFMLIfSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYST 356
Cdd:cd17365 218 GGVIGSLLLGWLADRFGPKRVLALFFAL-GAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRAT 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1169138901 357 TFGLYNFIGMSSSVLAPYITGVLsiytgsMKAGFYLASVFLLIG 400
Cdd:cd17365 297 GVGWALGVGRLGAILGPLLGGLL------LAAGLGPESVFLALA 334
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-195 |
3.93e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 3.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 20 RLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFL 99
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWriTF 179
Cdd:cd17325 280 LLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT--PF 357
|
170
....*....|....*.
gi 1169138901 180 FIFALLTIIVSIIMLF 195
Cdd:cd17325 358 LAAAALLLLAAVLFLL 373
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
76-406 |
4.68e-15 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 76.41 E-value: 4.68e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 76 GYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGY--------LLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSA 147
Cdd:cd17369 65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGS 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 148 IINSGGAIGLSLG---FIFSSYFTLS---LGFSWRITFFIFALLtIIVSIIMLFTIKndsknENLIKRKIDIEEKKFSSS 221
Cdd:cd17369 145 FPQLGAPVGLLLAtgvFLLLSALLSDeafLSWGWRIPFLLSAVL-VAVGLYIRLRLE-----ETPVFRRAKEAGQVVRAP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 222 IKLLLMN--RNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKhvkim 299
Cdd:cd17369 219 LVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGR----- 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 300 KFMLIFSSIFTFLIGF-------TNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGL-YNFIGMSSSVL 371
Cdd:cd17369 294 RPVYLAGALLAALFAFpffwlldTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLgYQLGAILGGGF 373
|
330 340 350
....*....|....*....|....*....|....*
gi 1169138901 372 APYITGVLSIYTGSMKAGFYLASVFLLIGYFSLIL 406
Cdd:cd17369 374 APLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-408 |
4.93e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 76.06 E-value: 4.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGWIFIygnrAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLA 100
Cdd:cd17321 1 LLLAVFLAALDV----TIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 101 VTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSlgFSWRITFF 180
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL--FGWRWIFL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 181 IFALLTIIVsiimlftikndsknenlikrkidieekkfsssiklLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQ 260
Cdd:cd17321 155 INVPIGLVA-----------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 261 GIEGSIAGYLSSIIALLALPGSILFSWINDRFQKhVKIMKFMLIFSSIFTFLIGFTNSTVW---IIVGLVLYGFMGKIAM 337
Cdd:cd17321 200 GYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP-RLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLVLLGLGLGLFA 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 338 DPIIVAfVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVL----------------------SIYTGSMKAGFYLASV 395
Cdd:cd17321 279 TPLTNA-ALSSVPKEKAGAASGILNTARQLGGALGVALLGALltaglsanlgdsgvaallsaaaAAFAAGFHLAFLVAAA 357
|
410
....*....|...
gi 1169138901 396 FLLIGYFSLILIK 408
Cdd:cd17321 358 LALLAALLALLLP 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
26-410 |
5.51e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 75.80 E-value: 5.51e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 26 FLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLS 105
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 106 EGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLsLGFIFSSYFTLSLG---FSWRITFFIF 182
Cdd:cd17371 85 QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGW-LLATLLAALLFPLLppeIAWRVLFLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 183 ALLTIIVSIIMLFtIKNDSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGI 262
Cdd:cd17371 164 ALPALLVLFIRRF-VKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 263 E-GSIAGYLSSIIaLLALPGSILFSWINDRFQKHVKIMKFMLIfSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPII 341
Cdd:cd17371 243 SfEGSAGYLVVTI-LGGFLGYLAGGFLADRIGRRNNFALFALG-SAISILLYFFLPLSPTLILILGFPLGFFASGPFSGM 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1169138901 342 VAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILIKEK 410
Cdd:cd17371 321 GAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALLLPET 389
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
46-407 |
1.98e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 74.18 E-value: 1.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 46 IKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGY-LLLISAWMISGIGQGT 124
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLpLLFLGYGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 125 FYGPQFALSSESIPNKyRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWriTFFIFALLTIIVSIIMLFTIKN----D 200
Cdd:cd17353 109 GYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT--TFLILGIIFLIIIVIGAFLIRDppkgW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 201 SKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYyLQTEQGIEGSIAGYLSSIIALLALP 280
Cdd:cd17353 186 VPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPI-GQEFAGLDAGIAALAVSILSIFNGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 281 GSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIGFTNST-VWIIVGLVLYGFMGKiAMDPIIVAFVANNAPQNLYSTTFG 359
Cdd:cd17353 265 GRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSVaVLFVLGVALIGFCYG-GGFALFPALTADFFGTKNAGTNYG 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1169138901 360 LYNFIGMSSSVLAPYITGVLsIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17353 343 LLYTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
49-406 |
2.04e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.19 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 49 DYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGP 128
Cdd:cd17329 29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 129 QFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFtlsLGFSWRITFFIFALLTIIVSIIMLFTIkndskNENLIK 208
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL---LLYSFRLLFLAAAVLFLLAALVLLFLL-----PETRPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 209 RKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTwLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWI 288
Cdd:cd17329 181 RRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST-LPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 289 NDRFqKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGfMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSS 368
Cdd:cd17329 260 VERF-RLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLT-LGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLG 337
|
330 340 350
....*....|....*....|....*....|....*...
gi 1169138901 369 SVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLIL 406
Cdd:cd17329 338 RAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
19-331 |
2.30e-14 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 74.20 E-value: 2.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI- 97
Cdd:cd17345 2 WQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIi 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 98 ---FLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGlslGFIFSSYFTLSLGF- 173
Cdd:cd17345 82 nilIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVG---GGLVGPLAGLGLAIf 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 174 ---SWRITFFIFALLTIIVSIIMLFTIKNDS-----------KNENLIKRKIDIEEKKFSSS---IKLLLMNRNLivsYI 236
Cdd:cd17345 159 gdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPeseglppieeyKGDYPEEADGEEEEQELSAWeifVKYVLKNKLL---WY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 237 VAFCSLYGFSV---MVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLI 313
Cdd:cd17345 236 IAIANVFVYLVrygILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALI 315
|
330 340
....*....|....*....|
gi 1169138901 314 GFTNST--VWIIVGLVLYGF 331
Cdd:cd17345 316 VYWLAPnvLVDLIALIALGF 335
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
57-406 |
4.59e-14 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 73.02 E-value: 4.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 57 IGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTfyGPQFALSSES 136
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVMALLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 137 IPNKYRTIGSAIInsGGAIGLS--LGFIFSSYFTLSLGFSWriTFFIFALLTIIVSIIMLFTIKNDSKNENlikrkidiE 214
Cdd:cd17472 112 TREENRTKAMALI--GASIGIAfaISMVLGPLLAAHLGVSG--LFLITAILSLVSLLILLFFVPDPPKIVQ--------I 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 215 EKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYL-QTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQ 293
Cdd:cd17472 180 SEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLtQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKM 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 294 KHVKIMKFMLIFSSIFTFLIGFTNStVWIIVGLVLYgFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAP 373
Cdd:cd17472 260 KQVFVSSILLIAVGFLLLLFAATSL-WLLIIGLIIF-FIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGG 337
|
330 340 350
....*....|....*....|....*....|...
gi 1169138901 374 YITGVLSIYTGSMKAGFYLASVFLLIGYFSLIL 406
Cdd:cd17472 338 ALGGLLWGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
23-357 |
1.48e-13 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 71.60 E-value: 1.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 23 IVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVT 102
Cdd:cd17343 6 ASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 103 GLSEGYLLLISAWMISGIGQGtFYGPQFA--LSSESIPNKYRTIGSAIINSGGAIGlSLGFIFSSYftLSLGFSWRITFF 180
Cdd:cd17343 86 SGSSSVWVFSILWFLNGLAQG-LGWPPCAkiLRKWFSPSQFGTWWSVLSTSMNLAG-SLGPILATL--LALSYGWRSTLS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 181 IFALLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVS---YIVAFCSLYGFSV---MVTWLPY 254
Cdd:cd17343 162 ISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKELLLSpflWLLSLGYLVVFGVktaVTDWGQL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 255 YLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRF------QKHVKIMKFMLIFSSI--------FTFLIGFTNSTV 320
Cdd:cd17343 242 FLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAvakhgsSSRGNPRMPLALVFMAgltvslhlFRVHITSDSSEL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1169138901 321 WIIVGLVLYGF--MGKIAMDPIIvafvAN-NAPQNLYSTT 357
Cdd:cd17343 322 FILLLGFLIGFslYGPIAIFGVI----ANeSAPSHLCGTS 357
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-379 |
2.69e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 70.81 E-value: 2.69e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 24 VFFLGWIFIYGNRAILTPVIGEIksdYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTG 103
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEA---FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 104 LSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSsyFTLSLGFSWRITFFIFA 183
Cdd:cd17333 80 ATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIAT--SLLTSELSWSWAYLIIG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 184 LLTIIVSIIMLFTikndSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIE 263
Cdd:cd17333 158 LIYLLLAILILLT----LFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 264 GSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMkFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFmGKIAMDPIIVA 343
Cdd:cd17333 234 DGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLV-LSGSGALLGLLILLLAPTLVVGLVATALLGL-FMAALFPTILS 311
|
330 340 350
....*....|....*....|....*....|....*.
gi 1169138901 344 FVANNAPQNLYSTTfGLYNFIGMSSSVLAPYITGVL 379
Cdd:cd17333 312 LGISNLPYAKGKGT-SVLLAAGSIGGAIIPFIMGFI 346
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
26-401 |
1.22e-12 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 69.19 E-value: 1.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 26 FLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLS 105
Cdd:PRK12307 24 WLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 106 EGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGgaigLSLGFIFSSYFTLSLG--FSWRITFFIFA 183
Cdd:PRK12307 104 SGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSG----FGIGNIIAAYFMPSFAeaYGWRAAFFVGL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 184 LLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKK---FSSSIKLLLMNRNLIVS---YIVAFCSLYGFSVMVTWLPYYLQ 257
Cdd:PRK12307 180 LPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAwsvFSLSMKGLFNRAQFPLTlcvFIVLFSIFGANWPIFGLLPTYLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 258 TEqGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMG-KIA 336
Cdd:PRK12307 260 GE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLK-KTFSIGLLMSFLFIFPLFRIPQDNYLLLGACLFGLMAtNVG 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 337 MDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTG-----SMKAGFYLASVFLLIGY 401
Cdd:PRK12307 338 VGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGlgaalTFIVAFWTATILLIIGL 407
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
50-290 |
1.55e-12 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 69.00 E-value: 1.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 50 YSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLS--EGYLLLISAWMISGIGQGTFYG 127
Cdd:TIGR00894 71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAagGGIALVVFCRVIQGLAQGSVSP 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 128 PQFALSSESIPNKYRTIGSAIINSGGAIGlSLGFIFSSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNENLI 207
Cdd:TIGR00894 151 ATHKIIVKWAPPKERSRLLGMSTSGFQLG-TFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCI 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 208 KRKID------IEEKKFSSS----IKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALL 277
Cdd:TIGR00894 230 SKFEKkyinssLQGQKGSTRqslpIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLF 309
|
250
....*....|...
gi 1169138901 278 ALPGSILFSWIND 290
Cdd:TIGR00894 310 AWLCSIFAGYLAD 322
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
22-407 |
2.28e-12 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 67.96 E-value: 2.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYS-KKWVLVPGFLISGIFLA 100
Cdd:cd17352 5 VFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGcRPVAIAGGLLAALGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 101 VTGLSEGYLLLISAWMISGIGQGTFYGPQFAlssesIPNKY----RTIGSAIINSGGAIGlslGFIFSSYFTLSLG-FSW 175
Cdd:cd17352 85 SSFATSLWQLYLTYGVLGGLGLGLIYSPAIV-----IVGQYfekkRGLATGIAVAGSGVG---TFVFPPLLRYLLDnYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 176 RITFFIFALLTIIVSIIMLFTIkndsknenlikrkidieekkfsssiklLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYY 255
Cdd:cd17352 157 RGALLILGGLCLNLCVCGLLLR---------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSY 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 256 LqTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVK-IMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFM-- 332
Cdd:cd17352 210 A-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLyLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCsg 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169138901 333 GKIAMDPIIVAfvaNNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17352 289 SYSSLTPVILA---DLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
37-408 |
4.29e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 67.22 E-value: 4.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFygP-QFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIFALLTIIVSIIMLF 195
Cdd:cd17504 93 LQGIGGAVF--PlAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGW--IVQHLGWRWIFWTAAPVAVLLAALVPL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 196 tikndsknenlikrkIDIEekkfsssiklLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQ----GIEGSIAGYLS 271
Cdd:cd17504 169 ---------------IDLR----------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 272 SIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQ 351
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVGPR-RVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPP 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1169138901 352 NLYSTTFGLY-NFIGMSSSVLAPYITGVLSIYT-----------GSMKAGFYLASVFLLIGYFSLILIK 408
Cdd:cd17504 303 DRTGIATGMNtVLRTIGSAIGPAIAGAILTTYTvsitsggvpteGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
19-199 |
6.26e-12 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 66.66 E-value: 6.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIF 98
Cdd:cd17488 2 IHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGII 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 99 LAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRIT 178
Cdd:cd17488 82 NILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGF--AALTYGWRAG 159
|
170 180
....*....|....*....|.
gi 1169138901 179 FFIFALLTIIVSIIMLFTIKN 199
Cdd:cd17488 160 MYVPGIIAILMGIVLCWRLRD 180
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
38-408 |
7.88e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 66.05 E-value: 7.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSlNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMI 117
Cdd:cd17502 14 IVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 118 SGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLgfSWRITFFIfallTIIVSIIMLFTI 197
Cdd:cd17502 93 QGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHL--SWRWCFYI----NLPIGGLALALL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 198 kndsknenlikrkidieekkfsssiklllmnRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALL 277
Cdd:cd17502 167 -------------------------------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 278 ALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNST---VWIIVGLVLYGFMGKIAMDPIIVAfVANNAPQNLY 354
Cdd:cd17502 216 LVIGSIISGALISKTGRYKPLIVIGTILMSVGAGLLTTLTLDtskWLLIGYLILLGLGLGIGFQQPLVA-VQNAVPPADV 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1169138901 355 STTFGLYNFIGMSSSVLapyitgvlsiyTGSMKAGFYLASVFLLIGYFSLILIK 408
Cdd:cd17502 295 GVATATNTFFRSLGGTL-----------GVAITDVFLVALALAALAFLLSLFLP 337
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-202 |
1.96e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 1.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIGEIksdYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSK--KWVLVPGFLISG 96
Cdd:COG2271 183 WLLALAYFLVYFALYGFLTWLPTYLVEV---RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 97 IFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWr 176
Cdd:COG2271 260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA- 338
|
170 180
....*....|....*....|....*.
gi 1169138901 177 iTFFIFALLTIIVSIIMLFTIKNDSK 202
Cdd:COG2271 339 -AFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
65-400 |
5.87e-11 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 63.72 E-value: 5.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 65 FLAYtIVQIPSGYLGDMYSKKWVLV-PGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRT 143
Cdd:cd17370 45 ALGS-LLRLFSGYLSDRTGKRKPLViLGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 144 IGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKKFSSSIK 223
Cdd:cd17370 124 KAFGLHRALDTLGAVLGPLLAALLLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFW 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 224 LLLMnrnlivsyIVAFCSLYGFSVMVTWLpYYLQTEQGIEGSIAGYL--SSIIALLALPGSILFswinDRFQKHvKIMKF 301
Cdd:cd17370 204 LYLL--------AVALFALGNFSFAFLIL-RAQELGLSAALIPLLYAlfNLVYALAAYPAGRLS----DRIGRK-KLLIL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 302 MLIFSSIFTFLIGFTNSTVWIIVGLVLYG-FMGkiAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLs 380
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGlYMG--AQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL- 346
|
330 340
....*....|....*....|
gi 1169138901 381 IYTGSMKAGFYLASVFLLIG 400
Cdd:cd17370 347 WDLISPSAAFLFSAVLALIA 366
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-402 |
7.84e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.36 E-value: 7.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMI 117
Cdd:cd17320 17 MYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 118 SGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIFALLTIIVSIIMLFTI 197
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGL--LLLFFGWRAIFVFLALLGLLLLLLVLLFL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 198 KndsknENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALl 277
Cdd:cd17320 175 P-----ETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAI- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 278 alpGSILFSWINDRFQKHVKIMKfMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkiamdPIIVAFVANNA--PQNLYS 355
Cdd:cd17320 249 ---ALILGSLLNGRLVRRFGPRR-LLRLGLLLLLAAALVLLLAALLGGLSLWPLVA-----PLFLIFFGFGLifPNATSL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1169138901 356 TTF----------GLYNFIGMSSSVLAPYITGVL-SIYTGSMKAGFYLASVFLLIGYF 402
Cdd:cd17320 320 ALEpfphvagtasALLGFLQFLIGALAGALVGLLpNGTALPMGLLILVLGLLALLLLI 377
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
144-412 |
8.20e-11 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 63.25 E-value: 8.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 144 IGSAIINSGGAIGLSL---GFIFSSYFTL-SLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNENLIKRKIDIEE-KKF 218
Cdd:COG2270 148 LGWALGYLGGVLLLLInlaLFLKPEAFGLpDAGEAVRISFLLTALWWLLFALPLFLFLPERPRPGPAPPRGAVRAGfREL 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 219 SSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKI 298
Cdd:COG2270 228 RRTLRELRRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVI 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 299 MKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkiamdPIIVA---FVANNAPQNLYSTTFGLYNFIGMSSSVLAPYI 375
Cdd:COG2270 308 LVSLVIWIVVCLAAYFLTTALAFWILGLLIGLVMG-----GIQALsrsLLARLIPPGREAEFFGLYALSGKAASFLGPLL 382
|
250 260 270
....*....|....*....|....*....|....*..
gi 1169138901 376 TGVLSIYTGSMKAGFYLASVFLLIGYFSLILIKEKDA 412
Cdd:COG2270 383 FGLVTQLTGSQRLGILSLIVFFVIGLVLLLRVKVPRG 419
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
49-406 |
3.60e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.05 E-value: 3.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 49 DYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFyGP 128
Cdd:cd17330 28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 129 QFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWriTFFIFALLTIIVSIIMLFTIkndsknenlik 208
Cdd:cd17330 107 AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYAL--PFLVAAALALLNLVLVLFFL----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 209 rkidieekkfsssiklllmnRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWI 288
Cdd:cd17330 174 --------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPR 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 289 NDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAPQNLYSTTFGLYNFIGMSS 368
Cdd:cd17330 234 LAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVF-PALSALLSKSVPSKEQGKAQGIIQSLQSLA 312
|
330 340 350
....*....|....*....|....*....|....*...
gi 1169138901 369 SVLAPYITGVLSIYTGSmKAGFYLASVFLLIGYFSLIL 406
Cdd:cd17330 313 RIIGPLLAGPLYSFLGP-GVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
38-364 |
4.66e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 60.67 E-value: 4.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMI 117
Cdd:cd17503 14 IVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRIL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 118 SGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIFALLTIIVSIIMLFti 197
Cdd:cd17503 94 QGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGW--LTDNLSWRWIFYINLPIGILALLLAPL-- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 198 kndsknenlikrkIDIEekkfsssiklLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALL 277
Cdd:cd17503 170 -------------LDLR----------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 278 ALPGSILFSWINDRF-QKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVG-LVLYGFMGKIAMDPIIVAFVANNAPQNLYS 355
Cdd:cd17503 227 SAILSPLVGRLLDKFgPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILpLFIRGLGMGLVFMPLNTLALNSLPPEQIGD 306
|
....*....
gi 1169138901 356 TTfGLYNFI 364
Cdd:cd17503 307 AT-ALFNTI 314
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
19-407 |
4.85e-09 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 58.40 E-value: 4.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPVIgeiksdyslnnaeiglmNSLFFLAYTIVQIPSGYLGDMYSKKWVLV----PGFLI 94
Cdd:PRK08633 28 HKILIQNTLIKAYDGSEQVILTAIV-----------------NALFLLPFLLLSSPAGFLADKFSKNRVIRivklFEVGL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 95 SGIFLAVTGLSEGYLLLIsAWMISGIgQGTFYGP-QFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFT----- 168
Cdd:PRK08633 91 TLLIVLAYYLGWFWLAFA-VTFLLGA-QSAIYSPaKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFesvng 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 169 ----LSLGFSWRITFFIFALltIIVSIIMLFTIKNDSK-NENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYI-VAFCSL 242
Cdd:PRK08633 169 ntpsEILGRIAPAGLVLLAV--AVLGLIFAYRLPKVPAaAPEVFDKKKYLFPKLLWRNLKLLRSDRVLWLAIIgLSYFWF 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 243 YGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALlalpGSILFSWINDRFQKH---VKIMKFMLIFSSIFTFLIGFTNST 319
Cdd:PRK08633 247 ISQLAQANFPAYAKEVLGLDNTFQVQYLLAASAI----GIGIGSLLAGRLSGRhieLGLVPLGALGLALSLFLLPTAPSL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 320 VWIIVGLVLYGFMGKIAMDPiIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLI 399
Cdd:PRK08633 323 ASVLVLFFLFGFSAGLFIVP-LNALIQFRAPEKELGKVLAANNFLQNVGMLLFLALTTLFSGLGLSPAGLFYLIALVTLI 401
|
....*...
gi 1169138901 400 GYFSLILI 407
Cdd:PRK08633 402 GTLYTLLL 409
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
23-195 |
5.37e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 58.02 E-value: 5.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 23 IVFFLGWIFIYGNRAILTPVIGEIKSDySLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVT 102
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVAD-LGPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 103 GLSEGYLLLISAWMISGIGQGTfYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIF 182
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYIN 158
|
170
....*....|...
gi 1169138901 183 ALLTIIVSIIMLF 195
Cdd:cd06179 159 AIFNALALILLFF 171
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
38-333 |
6.11e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 57.26 E-value: 6.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLS-EGYLLLISAWM 116
Cdd:cd17341 17 LFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAvSSYWGLLVLGF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFYGPQFALSSESIPNKYRT---IGSAIINSGGAIG-LSLGFIFSSYFTLSLGFSWRITFFIFALLTIIVSII 192
Cdd:cd17341 97 LLGFAGANFASGQPWASFWFPKEKIGGaagGIAGAGNMGVAVSqLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 193 MLFTIKN--DSKNENLIKRKIdieekkfsssIKLLLMNRN---LIVSYIVAFCSLYGFSVmvtWLPYYLQTEQGIEGSIA 267
Cdd:cd17341 177 VLLFGDDlpTGKASALEFLKV----------QLAVLKNYRtwiLSLLYGVTFGSFVGFSN---VLPTYFKTRFGLPLVTA 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 268 GYLSSIIALLALPGSILFSWINDRFQKhVKIMKFMLIFSSIFTFLIGFT----NSTVWIIVGLVLYGFMG 333
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGG-RRRLWWLFIVMTIGAALLSLSlptsGTNLVLFLALFVALGLG 312
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-410 |
7.41e-09 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 57.33 E-value: 7.41e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 53 NNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFAL 132
Cdd:TIGR00898 125 DAWKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVL 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 133 SSESIPNKYRTIGSAIINSGGAIGLsLGFIFSSYFTLslgfSWR-------ITFFIFALLTIIV--SIIMLFTIKNDSKN 203
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLIQVFFSLGL-VLLPLVAYFIP----DWRwlqlavsLPTFLFFLLSWFVpeSPRWLISQGRIEEA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 204 ENLIKR--KI----------------DIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLqteQGIEGS 265
Cdd:TIGR00898 280 LKILQRiaKIngkklpaevlslslekDLSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDL---GNLGGN 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 266 IagYLSSII-ALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkIAMdPIIVAF 344
Cdd:TIGR00898 357 I--YLDLFIsGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFG-ITS-AFQMVY 432
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169138901 345 VANNapqNLYSTTfgLYNF-IGMSS------SVLAPYITgVLSIYTGSMKAGFYlASVFLLIGYFSLILIKEK 410
Cdd:TIGR00898 433 LYTA---ELYPTV--VRNLgVGVCStmarvgSIISPFLV-YLGEKWLFLPLVLF-GGLALLAGILTLFLPETK 498
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
37-405 |
8.27e-09 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 56.80 E-value: 8.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLgdmySKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17477 13 GLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRL----IRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWF 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFYGPQFALS----SESIPNKYRTIGSAIINSGGAIGLSLGfifssYFTLSLGFSWRITFFIFALLTIIVSII 192
Cdd:cd17477 89 LLRFVMGIGLAGLFVVSeswlNALATNENRGRVLGLYSTVLGLGFALG-----PLLLALVGTAGALPFLIAAVLLLLALV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 193 MLFTIKNDSKnenlikrkidieEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLqTEQGIEGSIAGYLSS 272
Cdd:cd17477 164 PLLLTRRAAP------------EIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 273 IIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGkIAMDPIIVAFVANNAPQN 352
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAA-GPLYTLALALAGDRLPGD 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1169138901 353 LYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSmkAGFYLASVFLLIGYFSLI 405
Cdd:cd17477 310 ELVAANAALLLLYGLGSVIGPLLAGALMDAFGP--HGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
229-406 |
9.07e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 9.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 229 RNLIVSYIVAFCSLYGFSVMVTWLPYyLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSI 308
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 309 FTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKA 388
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRW 165
|
170
....*....|....*...
gi 1169138901 389 GFYLASVFLLIGYFSLIL 406
Cdd:COG2814 166 VFLVNAVLALLALLLLLR 183
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
235-410 |
1.45e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.89 E-value: 1.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 235 YIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIG 314
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 315 FTNSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYLAS 394
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALF-PAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILA 158
|
170
....*....|....*.
gi 1169138901 395 VFLLIGYFSLILIKEK 410
Cdd:pfam07690 159 ILSLLAAVLLLLPRPP 174
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-196 |
2.49e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 18 WIRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDM-YSKKWVLVPGFLISG 96
Cdd:cd17474 197 GRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 97 IFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWR 176
Cdd:cd17474 277 LSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL--LLEIFGLS 354
|
170 180
....*....|....*....|
gi 1169138901 177 ITFFIFALLTIIVSIIMLFT 196
Cdd:cd17474 355 APFLVGAAIALAAAVLLALL 374
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
17-199 |
3.08e-08 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 55.49 E-value: 3.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 17 YW-IRLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLIS 95
Cdd:PRK11663 19 YWrRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 96 GIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINS----GGA-IGLSLGFIfssyftlS 170
Cdd:PRK11663 99 GIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTahnvGGAlIPLVVGAI-------A 171
|
170 180
....*....|....*....|....*....
gi 1169138901 171 LGFSWRITFFIFALLTIIVSIIMLFTIKN 199
Cdd:PRK11663 172 LHYGWRYGMMIAGIIAIVVGLFLCWRLRD 200
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
14-195 |
5.45e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 5.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 14 MTPYWIRLVIVFFLGWIFIY-GNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGF 92
Cdd:cd17316 171 LALLLRRRTLLLILLWFFISfGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 93 LISGIFLAVTGL---SEGYLLLISAWMISGIGQGtFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTL 169
Cdd:cd17316 251 ILSGILALPLFYllsGSPTLLLLLLFILSFFVGG-VWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329
|
170 180
....*....|....*....|....*.
gi 1169138901 170 SLGFSwrITFFIFALLTIIVSIIMLF 195
Cdd:cd17316 330 STGGT--GVPALILALLAIVALIVAL 353
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
16-212 |
6.25e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.52 E-value: 6.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 16 PYWIRLVIVFFLGWIFIYGNRAILTPVIgeiKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLIS 95
Cdd:COG2211 228 RPFLLLLLAYLLFFLALALVAALLLYYF---KYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 96 GIFLAVTGLS--EGYLLLISAWMISGIGQGTFYGPQFALSSESIP-NKYRT----------IGSAIINSGGAIGLSL--- 159
Cdd:COG2211 305 ALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDyDEWKTgrrreglyfgIFTFAIKLGQALAGALagl 384
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1169138901 160 -----GFIFSSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNENLIKRKID 212
Cdd:COG2211 385 llalfGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
13-195 |
6.55e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 6.55e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 13 KMTPYWIRLVIVFFLGWIFIYGNRAILTPVIgeiKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGF 92
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALTVLLPLLA---KEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 93 LISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLG 172
Cdd:cd06173 282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL--LADA 359
|
170 180
....*....|....*....|...
gi 1169138901 173 FSWRITFFIFALLTIIVSIIMLF 195
Cdd:cd06173 360 LGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-407 |
6.71e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.15 E-value: 6.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLnnaeIGLMNSLFFLAYTIVQIPSGYLGDMYSK-KWVLVPGFLISGIFL 99
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSM----IGIILGAYGISQMLLRIPLGILSDRIGKrKLFIIIGLLFTVLAS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGT------FYGPQFALSsesipNKYRTIGsaIINSGGAIGLSLGFIFSSYFTLSLGf 173
Cdd:cd17490 77 LIMILFPSPWGLLIARFLSGIAAATwvsftvLYASYFPPD-----EAAKAMG--LINLVNNLGQLIAFLIGGLIAEHFG- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 174 sWRITFFIFALLTIIVSIIMLFTikndsKNENLIKRKIDIEEKKFSSSIKlllmNRNLIVSYIVAFCSLY-GFSVMVTWL 252
Cdd:cd17490 149 -MRAPFLLAALAGVLGFILSLFI-----KEERREKKPVLTELKELLSVLK----DKKLLFFSLLAILQQMiTFSTTFGFT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 253 PYYLQtEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFM 332
Cdd:cd17490 219 PLIAK-QLGASSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFG 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1169138901 333 GKIAMdPIIVAFVANNAPQNLYSTTFGLYNFI---GMSssvLAPYITGVLSIYTGsMKAGFYL-ASVFLLIGYFSLILI 407
Cdd:cd17490 298 TGILF-PLLMSLSIEGVPAEQRSTAMGFFQAIyalGMF---LGPVLVGIISEAFG-LQTGFFViGVIALLAAILSLAYY 371
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
62-198 |
8.14e-08 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 51.11 E-value: 8.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 62 SLFFLAYTIVQI----PSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESI 137
Cdd:TIGR00880 1 GLLLAGYALGQLiyspLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169138901 138 PNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIFALLTIIVSIIMLFTIK 198
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGV--LAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
20-406 |
1.17e-07 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 53.57 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 20 RLVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYS-KKWVLVPGFLISGIF 98
Cdd:cd17314 3 FVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGpRPLMALAGIMVLAGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 99 LAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKyRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRIT 178
Cdd:cd17314 83 TYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 179 FFIfALLTIIVSIIMLFTIKNDSKNEnlikrKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQT 258
Cdd:cd17314 162 ILG-ILAAIVLSVVSLLGFKEPPDNQ-----ARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 259 EQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSS--IFTFLIGFTNSTVWIIVGLVLYGFM--GK 334
Cdd:cd17314 236 LQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGlgLCAFLFLLKMTPVGLVLTGSLLGFSygGL 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1169138901 335 IAMDPIIVAFVANNApqnLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLIL 406
Cdd:cd17314 316 FTVYPATVSTVFGTE---SFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLA 384
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
19-407 |
6.35e-07 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.10 E-value: 6.35e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWIFIYGNRAILTPvigEIKSDYSLNNAEIGLMnsLFFLAY-TIVQIP-SGYLGDMYSKKWVLVPGFLISG 96
Cdd:cd17393 1 RLAVAAFFFINGILMASWATRIP---AIKDRLGLSDAALGLL--LLALGVgALVAMPlAGRLVARFGSRRVTRLGALLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 97 IFLAVTGLSEGYLLLISAWMISGIGQGtfyGPQFALSSESIpNKYRTIGSAIINS-------GGAIGLSLGFIfssyfTL 169
Cdd:cd17393 76 LALLLLGLAPSVPALALALFLFGAANG---ALDVAMNAQGV-AVERAYGRPIMSSlhamwslGGLAGALLGAA-----AI 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 170 SLGFSWRITFFIFALLTIIvsiIMLFTIKNDSKnenlIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMV 249
Cdd:cd17393 147 GAGVSPGVHLLAAAVLLLL---AALVAIRALLP----GTGEAAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAA 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 250 TWLPYYLQTEQGIEGSIA--GYLSSIIALLAlpGSILFSWINDRFQKhVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLV 327
Cdd:cd17393 220 DWSALYLRDVLGASAALAalGYAVFSLAMTV--GRLFGDRLVDRFGD-VAVLRAGALLAALGLLLALLAPSVWVALAGFA 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 328 LYGFmGKIAMDPIIVAFVANNAPQNlYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsmkagfyLASVFLLIGYFSLILI 407
Cdd:cd17393 297 LMGL-GLSVVVPLAFSAAGALPGLA-AGIAVARVATLGYLGFLVGPPLIGFLADATG-------LRTAFLVVALLALLVA 367
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
22-316 |
1.32e-06 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 50.32 E-value: 1.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 22 VIVFFLGWIFIYGNRAILTpvigeIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAV 101
Cdd:cd17336 10 LLGLLQGAVVSYFVSTITT-----IEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 102 TGLSEgylLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFT----------LSL 171
Cdd:cd17336 85 LALPH---FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLriyvdfsrvpLGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 172 GFS-------WRITFFIFALLTIIVSIIMLFtikndsknenlikrkidieekkfsssiklllMNRNLIVSYIVAFCSLYG 244
Cdd:cd17336 162 TPDdprwigaWWLGFLILGILLLIVSIPLFF-------------------------------FPPIFILLLLAIVFESFA 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1169138901 245 FSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALL-ALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFT 316
Cdd:cd17336 211 ISGFSTFLPKYLETQFRLSASLASLLTGLILVPgAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYIS 283
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
62-382 |
1.81e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.50 E-value: 1.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 62 SLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKY 141
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 142 RTIGSAIINSGGAIGLSLGFIFSSYFTlslgfSWRITFFIFALLTIIVSIIMLFTIKndsknenlikrkidieekkfsss 221
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIR-----DWRWLQLAISLPGLLFLLLLWWLPR----------------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 222 iklllmnRNLIVSYIVAFCSL--YGFSVMVTWLPYYLqteqgiegsiagYLSSIIA-LLALPGSILFSWINDRFQKHVKI 298
Cdd:cd17317 164 -------RTIIVGLIWFVTSLvyYGLSLNSSNLGGNL------------YLNFFLSgLVEIPAYFLALLLLDRLGRRWTL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 299 MKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGV 378
Cdd:cd17317 225 SGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLL 304
|
....
gi 1169138901 379 LSIY 382
Cdd:cd17317 305 GKIG 308
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
229-410 |
2.01e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.53 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 229 RNLIVSYIVAFCSLYGFSVMVTWLPYYLQtEQGIEGSIA-----GYLSSIIALLALPGSILFSWINDRfqkhvKIMKFML 303
Cdd:PRK09874 14 RNLTVAWLGCFLTGAAFSLVMPFLPLYVE-QLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADR-----KGRKIML 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 304 IFS----SIFTFLIGFTNSTVWIIVGLVLYGFMGKIAmdPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVL 379
Cdd:PRK09874 88 LRSalgmGIVMVLMGLAQNIWQFLILRALLGLLGGFV--PNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLL 165
|
170 180 190
....*....|....*....|....*....|.
gi 1169138901 380 SIYTGSMKAGFYLASVFLLIGYFSLILIKEK 410
Cdd:PRK09874 166 ADSYGLRPVFFITASVLFLCFLVTLFCIREN 196
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
46-407 |
5.46e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 48.40 E-value: 5.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 46 IKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYL-GDMYSKKWVlvPGFLIS-GIFLAVTGLSEGYLLLISAWMISGIGQG 123
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLlQRFPPSKWL--SVFIVLwGLLTLLTAAVKNFGGLIALRFFLGLFES 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 124 TFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGF----SWRITFFIFALLTIIVSIIMLFTIKN 199
Cdd:cd17327 110 GVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVgglaGWRWLFIIEGLITIIIGLVIFFWLPD 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 200 DSKN-------------ENLIKRKIDIEEKKFS-SSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGS 265
Cdd:cd17327 190 NPSKawflteeekelavERLRANQTGKGDQKFKwKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQ 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 266 IAgYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTnSTVWIIVGLVLYGFMGKIAMDPIIVAFV 345
Cdd:cd17327 270 TN-LLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIILLAA-PNPPGAYFAAYILGGGSYAGFPILLSWI 347
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169138901 346 ANNAPqNLYS--TTFGLYNFIGMSSSVLAPYitgvlsIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:cd17327 348 SSNCA-GYTKraTVLAIMLIFYNVGNIVAPQ------IFRAGDAPRYIPGNIALLVCACVSIVL 404
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
39-409 |
6.24e-06 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 47.96 E-value: 6.24e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 39 LTPVIGEIKSDYS----LNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLvpgfLISGIFLAVtglseGYLLLISA 114
Cdd:cd17358 21 SSPALPSLMSDNSlslpLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTL----LISAIPCIL-----GWLLIAFA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 115 ---WM------ISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftlslgFSWRITFFIFALL 185
Cdd:cd17358 92 kdvWMlylgrfLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSF------LPWRTLALIGAIP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 186 TIIVSIIMLF--------------------------TIKNDSKNENLIKRKIDIEEKKFSSSIKLLLMNRNLIVSYIVAF 239
Cdd:cd17358 166 PVVFLILLFFipesprwlakkgreeeaekslqflrgKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPLVIGL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 240 C--SLYGFSVMVTWLPY----YLQTEQGIEGSIAgylSSIIALLALPGSILFSWINDRFQKhvkimKFMLIFSS----IF 309
Cdd:cd17358 246 GlmLFQQLSGINAVIFYassiFDEAGSGLDPNTA---TIIIGVVQVVGTLVATLLVDRLGR-----RPLLLVSAigmgIG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 310 TFLIGFTN----------STVWI-IVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGV 378
Cdd:cd17358 318 LLALGLYFylqehgallsSVSWLpLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPF 397
|
410 420 430
....*....|....*....|....*....|.
gi 1169138901 379 LSIYTGSMKAGFYLASVFLLIGYFSLILIKE 409
Cdd:cd17358 398 LTLAWGASGTFWIFAGICGLALVFVLLFVPE 428
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
51-404 |
1.01e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 47.64 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 51 SLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWvlvpGFLISGIFLAVTGLSEG-------YLLLISAWMISGIGQG 123
Cdd:cd17357 45 SELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRKN----GLLISNALLVVSSLLMFlsksaksPELLIFGRFLVGIACG 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 124 TFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALLtIIVSIIMLFTIKNDSKN 203
Cdd:cd17357 121 LSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIP-ALLQLAALPFFPESPKF 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 204 -----------------------------ENLIKRKIDIEEKKFSSSIKLLLMNRN---LIVSYIVAFCSLYGFSVMVTW 251
Cdd:cd17357 200 lliskgdeeeaekslkflrgieddvdqelEEIKKESEQMGDQKQVSLMQLLRDPSLrlpLLLVLVVSASQQFSGINAIFF 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 252 LPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMK---FMLIFSSIFTFLIGFTNSTVWI----IV 324
Cdd:cd17357 280 YSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLIslsVCAVALLLMSVFLFLSEQNSWMsygcIV 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 325 GLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFY--LASVFLLIGYF 402
Cdd:cd17357 360 AIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFaiPCALFLLYLYR 439
|
..
gi 1169138901 403 SL 404
Cdd:cd17357 440 YL 441
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
239-332 |
1.27e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 46.81 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 239 FCSLYGFSVMVTWLPYYLQtEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNS 318
Cdd:cd17335 7 FFFFAALGSLLPFLSVYLK-QLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQ 85
|
90
....*....|....*
gi 1169138901 319 TVW-IIVGLVLYGFM 332
Cdd:cd17335 86 IFWlLLLLVILGAFF 100
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
229-409 |
1.28e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.73 E-value: 1.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 229 RNLIVSYIVAFCSLYGFSVMVTWLPYyLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSI 308
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRY-GRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 309 FTFLIGFTNSTVWIIVGLVLYGFMGKIAMdPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLsIYTGSMKA 388
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLM-PGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLL-VAALGWRW 169
|
170 180
....*....|....*....|.
gi 1169138901 389 GFYLASVFLLIGYFSLILIKE 409
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPE 190
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
44-197 |
1.50e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.87 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 44 GEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQG 123
Cdd:cd17476 22 PIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPA 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169138901 124 TFYGPQFALSSESI-PNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWriTFFIFALLTIIVSIIMLFTI 197
Cdd:cd17476 102 FLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPW--IFWFLAILAAIVAVAAIFWT 174
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
37-299 |
1.65e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.80 E-value: 1.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17339 16 TSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 IS-GIGQGTFYGPqfALSSESIPNK---YRTIGSAIINSGGAIGLSLgfifSSYFTLSLGFSWRITFFIFALLTIIVSII 192
Cdd:cd17339 96 AGaGIAVGNVLLP--SLIKRDFPRRvglMTGLYTTSMNLGAALASGL----SVPLAQALGGGWRGALAIWALPALLALLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 193 MLFtikndskneNLIKRKIDIEEKKFSSSIKLLlmnRNLIVSYIVAFCSL--YGFSVMVTWLPYYLQtEQGIEGSIAGYL 270
Cdd:cd17339 170 WLP---------QLRRRKRAAAAAAPLTKISVW---RSPLAWQVTLFMGLqsLLFYTLMAWLPTILI-DAGLSAATAGWL 236
|
250 260
....*....|....*....|....*....
gi 1169138901 271 SSIIALLALPGSILFSWINDRFQKHVKIM 299
Cdd:cd17339 237 LSLFQLVGIPASLLVPILATRLKNQRPIV 265
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
48-195 |
3.11e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 48 SDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYG 127
Cdd:cd17370 227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQES 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1169138901 128 PQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWritFFIFALLTIIVSIIMLF 195
Cdd:cd17370 307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA---AFLFSAVLALIALLLLL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
2-194 |
3.41e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 2 KQKVLIENKKNKMTPYWIRLVIVFFLGWIFIYGnraILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDM 81
Cdd:cd06174 189 SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS---FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDR 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 82 YSK-KWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLG 160
Cdd:cd06174 266 LIGrKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345
|
170 180 190
....*....|....*....|....*....|....
gi 1169138901 161 FIFSSYFtLSLGFSWRITFFIFALLTIIVSIIML 194
Cdd:cd06174 346 PLLAGFL-LAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
47-195 |
4.13e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 4.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 47 KSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPG---FLISGIFLAVTGLSEGYLLLISAWMISGIGQG 123
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1169138901 124 TFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIF---SSYFTLSLGfsWRITFFIFALLTIIVSIIMLF 195
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFglgLNKTSNSDG--WRIPLGLQLVPALLLIIGLLF 190
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
150-331 |
5.27e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 45.29 E-value: 5.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 150 NSGGAIGLSLGFIFSSYFTLSLG-FSWRITFFIFALLTIIVSIIMLFTIKndsknENLIKRKIDIEEKKFSSSIKLLLMN 228
Cdd:cd17332 146 TIGGLLVTVLPPPLVAYFGGGNAsRGYFLTALIIGIIGIILLLICFFGTR-----ERVVPPEEEKSKLPLLKSLKALLKN 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 229 RNLIVSYIVAFCSLYGFSVMVTWLPYYLQ---TEQGIEGSIAGYLSSIIALLALPGSILFSWINDRfqKHVKIMKFMLIF 305
Cdd:cd17332 221 RPFLILLLAYLLYFLAFNIVNTVLVYYFKyvlGGRAELVLLLLLILSGALLALLPWPPLKKRFGKK--KAFFIGLLLAIL 298
|
170 180
....*....|....*....|....*.
gi 1169138901 306 SSIFTFLIGFTNsTVWIIVGLVLYGF 331
Cdd:cd17332 299 GLLLLFFLPPGN-LVLILVLAVLAGI 323
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
21-408 |
6.70e-05 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 44.74 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWV-LVPGFLISGIFL 99
Cdd:cd17422 4 VAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVvMVGGLLISLGMI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIpNKYRTIGSAIINSGGAIGlslGFIFSSYFT-LSLGFSWRIT 178
Cdd:cd17422 84 TASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYF-KKRRSLVTAIASTGECFA---VFAFAPAFTaLKESIGWRYC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 179 FFIFALLTIIVSIimlftikndsknenlikrkidieekkFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQT 258
Cdd:cd17422 160 LLVVGALQLNIVV--------------------------CGALLRVLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 259 eqGIEGSIAGYLSSIIALLALPGSILFSWI-NDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFM-GKIA 336
Cdd:cd17422 214 --GIDQDWAAYMLSAMAIAELFGRISAGWVlNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMfGTVA 291
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1169138901 337 MDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILIK 408
Cdd:cd17422 292 GTHIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLALVR 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-195 |
8.24e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.49 E-value: 8.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 46 IKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTF 125
Cdd:cd17473 224 LQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL 303
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 126 YGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFtLSLGFSWRITFFIFALLTIIVSIIMLF 195
Cdd:cd17473 304 LPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPL-VNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
57-332 |
8.71e-05 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 44.61 E-value: 8.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 57 IGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTG-LSE-----GYLLLISAWMISGIGQGTFYGPQF 130
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGvLTEwlhfyNKYLYCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 131 ALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYfTLSLGFSWriTFFIFALLTIIVSIIMLFTIknDSKNENLIkrk 210
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASS-VLDYGYEY--AFLVTSSLLFAGAIVVFFGL--LSSPPGVI--- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 211 idieekkfsssiklllmnrnlivSYIVAFCSL----YGFsvmVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFS 286
Cdd:cd17342 217 -----------------------PYSLAYACLklvnYSF---FFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAG 270
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1169138901 287 WINDRFQKHVKIMKFMLIFSSIFTFLIGFT-NSTVWIIVGLVLYGFM 332
Cdd:cd17342 271 YISDRMGSRSPVVVVMLLLAIPSLFVYSHSpSDKVLNAFVMTITGFF 317
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
50-184 |
1.20e-04 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 44.00 E-value: 1.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 50 YSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSE----GYLLLISAwmISGIGQGTF 125
Cdd:cd17381 60 YDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlgaGYLIAVRA--LEGLGEGVT 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1169138901 126 YGPQFALSSESIP----NKYRTIGSAIINSG--------GAIGLSLGFIFSSYFTLSLGFSWRITFFIFAL 184
Cdd:cd17381 138 FPAMHAMWASWAPplerSRLLTISYAGAQLGtvvslplsGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM 208
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
38-193 |
2.14e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 43.53 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 38 ILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMI 117
Cdd:PRK03893 38 LITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLV 117
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1169138901 118 SGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYftLSLGFSWRITFFIfALLTIIVSIIM 193
Cdd:PRK03893 118 IGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSL--VVPVWGWRALFFI-GILPIIFALWL 190
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
235-392 |
2.24e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.98 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 235 YIVAFCSLYGFSVMVTWLPYYLQtEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLIG 314
Cdd:cd17390 2 YLVGFLDLFGVSMILPLLSTHIR-SLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRR-PVLLICLLLTALGYVLLG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1169138901 315 FTNSTVWIIVGLVLYGFMGKIAMdpIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsmkaGFYL 392
Cdd:cd17390 80 FSTSLALLFLSRIPLGIFKHTQS--LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG----GFYY 151
|
|
| ATG22 |
pfam11700 |
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ... |
144-407 |
2.42e-04 |
|
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.
Pssm-ID: 371676 Cd Length: 479 Bit Score: 43.02 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 144 IGSAIINSGGAIGLSLG---FIFSSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDS-----KNENLIKRKIdiee 215
Cdd:pfam11700 194 RGFGIGYIGGILVQIISiiiVYALGSTASNNTWALRLAITFAGCWWIIFTIPWALWLRPRPgpplpSGLNYLIYGW---- 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 216 KKFSSSIKLLLMNRNlIVSYIVAFCSLY-GFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqk 294
Cdd:pfam11700 270 KQLGRTLKQARKLKD-ALLFLVAWFLLSdGIATVSSTAVLFAKTELGMSTSQLTLLNIVAMIAAVLGAFLWPFVSRRF-- 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 295 HVKIMKFMLIFSSIFTF-----LIGFtnstVWIIVGL----------VLYG-FMGkiAMDPIIVAFVANNAPQNLYSTTF 358
Cdd:pfam11700 347 NLKTKQTLIACIVLFELiplygLLGI----ILGKIGLknpwefwvlqAFYGlVLG--GLRSYSRSLYSELIPRGKEAQFF 420
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1169138901 359 GLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSLILI 407
Cdd:pfam11700 421 SLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLLLLV 469
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-402 |
2.74e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 42.64 E-value: 2.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 58 GLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGtFYGPQFALSSESI 137
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 138 PNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFswRITFFIFALLTIIVSIIMLFTIKNDSKNenlIKRKIDIEEKK 217
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGI--RNVFFITGGLLFLAFLLTLFFVKEDFKP---VEKKKMVSTKE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 218 FSSSIKlllmNRNLIVSYIVAFCSLYGFSVMVT-WLPYYLQTEQGIEGSIAgYLSSIIALLALPGSILFS----WINDRF 292
Cdd:cd17391 193 VWNSVP----NPSLLISLFVTTFIIQLANQSIEpILTLYIRQLMGDASNLA-FISGLVFSATGVSSLLSAprlgKLGDRI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 293 QKHVKIMKFmLIFSSIFTFLIGFTNSTVWIIVGLVLYGFmGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLA 372
Cdd:cd17391 268 GHHRILLGA-LLASALLYIPQAFVQTPWQLGILRFLLGL-ATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAG 345
|
330 340 350
....*....|....*....|....*....|
gi 1169138901 373 PYITGVLSIYTGsMKAGFYLASVFLLIGYF 402
Cdd:cd17391 346 PLLGSAIAAHFG-YRAVFVVTALLVLLNAI 374
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
19-331 |
3.13e-04 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 42.61 E-value: 3.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 19 IRLVIVFFLGWiFIYGNRAILTP-VIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI 97
Cdd:PRK03699 6 IKLTWISFLSY-ALTGALVIVTGmVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 98 FLAVTGLSEGYLLLISAWMISGIGQGTFygpqFALSSESIPNKY--RTIGSAIINSGGAIGLSlGFIFSSY--FTLSLGF 173
Cdd:PRK03699 85 AVAGLMFSHSLALFSIAMFVLGVVSGIT----MSIGTFLITHVYegKQRGSRLLFTDSFFSMA-GMIFPIIaaYLLARSI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 174 SWRITFFIFALLTIIVSIIMLFTikndskNENLIKRKIDIEEKKFSSSIklllMNRNLIVSYIVAFCSLYGFSVMVTWLP 253
Cdd:PRK03699 160 EWYWVYACIGLVYVAIFILTLFS------EFPALGKHAPKADKPVAKEK----WGIGVLFLAIAALLYILAQLTFISWVP 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1169138901 254 YYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHVKIMKFMLIfSSIFTFLIGFTNSTVWIIVGLVLYGF 331
Cdd:PRK03699 230 EYAQKKFGMSLEDAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGL-ALVLMYLFVNTDDPSHLLYAILGLGF 306
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
152-333 |
3.20e-04 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 42.61 E-value: 3.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 152 GGAIGLSLGFIF------SSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKN-----DSKNEnLIKRKIDIEEKKFSS 220
Cdd:cd17398 139 GNQLGVALGFVLppllvpNSENKDEIGKGLSILFYGVAGICTALFILVIIFFKEkppipPSRAQ-AAAQELRSEDQSYLG 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 221 SIKLLLMNRN---LIVSYIVAFCSLYGFSVMV--TWLPYYlqteqGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKH 295
Cdd:cd17398 218 SLKRLFKNKGfllLLITYGINTGVYYAISTLLnqMVLEYF-----PNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKY 292
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1169138901 296 VKIMKFMLIFSSI----FTFLIGFTNSTVWIIVGLVLYGFMG 333
Cdd:cd17398 293 KETTIIVYILSFIgmvaFTFTLDLGSIWVVFLTAGALGFFMT 334
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
21-199 |
3.54e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 21 LVIVFFLGwIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLA 100
Cdd:cd17323 1 VFIISFLT-FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 101 VTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGfsWRITFF 180
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG--WRWIFW 157
|
170
....*....|....*....
gi 1169138901 181 IFALLTIIVSIIMLFTIKN 199
Cdd:cd17323 158 FLAIISGFCLILIFLFLPI 176
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
231-409 |
3.67e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.21 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 231 LIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFT 310
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRK-PVMLAGLLLRALGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 311 FLIGFTNSTVWIIVGLVLYGFMGKIaMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLsiYTGSMKAGF 390
Cdd:cd17329 80 ALLGFAHSPWLFAIALVLTGFGGGL-FEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLF 156
|
170 180
....*....|....*....|
gi 1169138901 391 YL-ASVFLLIGYFSLILIKE 409
Cdd:cd17329 157 LAaAVLFLLAALVLLFLLPE 176
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
57-194 |
3.82e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 42.51 E-value: 3.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 57 IGLMNSLFFLAYTIVqipSGYLGDMYSKKWVLVPGFLISGI-----FLAVTGlSEGYLLLISAWMISGIGQGTFYGPQFA 131
Cdd:cd17369 269 AVLIASVVAAITIPL---FGWLSDRVGRRPVYLAGALLAALfafpfFWLLDT-GSTWLIVLAAVVVLGVLHGMMYGPQAA 344
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169138901 132 LSSESIPNKYRTIGSAI-INSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALLTIIVSIIML 194
Cdd:cd17369 345 FLAELFPTRVRYTGASLgYQLGAILGGGFAPLIATALVAATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
235-409 |
4.32e-04 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 42.03 E-value: 4.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 235 YIVAFCSLYGFSVMVTWLPYYLQtEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFqKHVKIMKFMLIFSSIFTFLIG 314
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 315 FTNSTVWIIVGLVLYGFmGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVL-SIYTGSMKAGFYLA 393
Cdd:cd06174 80 FAPSFWLLLLGRFLLGL-GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILaSSLGFGWRAVFLIA 158
|
170
....*....|....*.
gi 1169138901 394 SVFLLIGYFSLILIKE 409
Cdd:cd06174 159 AALALLAAILLLLVVP 174
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
20-195 |
5.26e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 41.80 E-value: 5.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 20 RLVIVFFLgWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNslfFLAYTIVqipsGYLGDMYSKKWVLVPGFLISGIFL 99
Cdd:cd17317 164 RTIIVGLI-WFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVE---IPAYFLA----LLLLDRLGRRWTLSGSLLLAGLAC 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 100 AVTGLS--EGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLslgfIFSSYFTLSLGFSWRI 177
Cdd:cd17317 236 LVTALLpdDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGA----ILAPFIVLLGKIGPLL 311
|
170
....*....|....*...
gi 1169138901 178 TFFIFALLTIIVSIIMLF 195
Cdd:cd17317 312 PLIIFGVLALLGGLLTLL 329
|
|
| MFS_Atg22_like |
cd17483 |
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily ... |
63-404 |
7.09e-04 |
|
Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; Atg22 (also known as Aut4) protein functions as a vacuolar effluxer which mediates the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation. Members of this family belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341036 Cd Length: 467 Bit Score: 41.49 E-value: 7.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 63 LFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLI--SGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNK 140
Cdd:cd17483 101 LLTFTIIGSISSILFLFVPSPSLWWLAALLYIvsNICYGASLVFYNSFLPILARNHPDVRAARDKGSSLSAEATEEEISL 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 141 YRTIGSAIINSGGAIGLSLGFIFSsyfTLSLGFSW---------RITFFIFALLTIIVSIIMLFTIKNDSKNENLIKR-K 210
Cdd:cd17483 181 EEKVSSRISSLGFASGYVGGIIVQ---IISIIILFvlgnsivslRIAIAVVGVWWLIFSVPTFLWLKPRPGPPLPGGShP 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 211 IDIEEKKFSSSIKLLLMNRNLIVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWIND 290
Cdd:cd17483 258 IFYSWKSLFRTLKHARKLPETFIFLLAWFFLSDGINTISSTAVLFAKSQLHMSTLQLILIGLLTPITAILGAFFFPRIQR 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 291 RFQ-KHVKIMKFMLIFSS---------IFTFLIGFTNST-VWIIVglVLYGFMgkiaMDPIIV---AFVANNAPQNLYST 356
Cdd:cd17483 338 RFNlSTKTMLMLIVVLTAliplygllgFFTGKFGLKHPWeMYVLA--VWFGFF----LGGLQSysrSLFSELIPPGHEAE 411
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1169138901 357 TFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSL 404
Cdd:cd17483 412 FFSLFSITDKGSSWIGPLVVGAIIDATGNIRYGFIFLFALFVLPLPLL 459
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
76-324 |
9.00e-04 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 41.26 E-value: 9.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 76 GYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGY--------LLLISAWMISGIGQGTFYGPQFALSSESIPNKYRtigsA 147
Cdd:PRK09952 85 GHFGDRLGRKRMLMLTVWMMGIATALIGLLPSFstigwwapVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKK----A 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 148 IINSGGAIGLSLGFIFS-------SYFTLSLGFS---WRITFfifaLLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKK 217
Cdd:PRK09952 161 FYSSGVQVGYGVGLLLStglvsliSMMTTDEQFLswgWRIPF----LFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAK 236
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 218 FSSSIKLLLMNRNLIVSYIVA--FCSLYGFSVMVTWLPYYLQTEQGIEGSI---AGYLSSIIALLALPgsiLFSWINDRF 292
Cdd:PRK09952 237 KRIPVIEALLRHPGAFLKIIAlrLCELLTMYIVTAFALNYSTQNLGLPRELflnIGLLVGGLSCLTIP---CFAWLADRF 313
|
250 260 270
....*....|....*....|....*....|....
gi 1169138901 293 -QKHVKIMKFMLIFSSIFTFLIGF-TNSTVWIIV 324
Cdd:PRK09952 314 gRRRVYITGALIGTLSAFPFFMALeAQSIFWIVF 347
|
|
| MFS_FucP_like |
cd17394 |
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ... |
21-97 |
9.06e-04 |
|
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340952 [Multi-domain] Cd Length: 401 Bit Score: 41.05 E-value: 9.06e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1169138901 21 LVIVFFLGWIFIygnRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGI 97
Cdd:cd17394 3 LVTSLFFLWGFA---TNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAI 76
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
49-195 |
1.13e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 41.10 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 49 DYSLNNAEIGLmnslFFLAYTIVQIPS----GYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGT 124
Cdd:PRK11551 44 EFGLDVAQMGW----AFSAGILGLLPGallgGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGG 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1169138901 125 FYGPQFALSSESIPNKYRtiGSAI------INSGGAIGLSLGfIFSSYFTlslgfSWRITFFI--FALLtIIVSIIMLF 195
Cdd:PRK11551 120 ALPNLIALTSEAVGPRLR--GTAVslmycgVPFGGALASVIG-VLAAGDA-----AWRHIFYVggVGPL-LLVPLLMRW 189
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
76-409 |
1.80e-03 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 40.42 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 76 GYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGY--------LLLISAWMISGIGQGTFYGPQFALSSESIPNKYRTIGSA 147
Cdd:cd17366 61 GPLGDKYGRQKVLAITIILMAASTFCIGLLPTYatigvwapILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGS 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 148 IINSGGAIGLSLGFIFSSYFTLSLG------FSWRITFFIFALLTIIVsiimlftikndsknenlikrkidieekkfsss 221
Cdd:cd17366 141 WLEFGTLAGFILGAGLVTLLTLLLTeaqmldWGWRIPFLIAAPLGLVG-------------------------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 222 iklLLMNRNLIVSY-IVAFCSLYGFSVMvTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRF--QKHVKI 298
Cdd:cd17366 189 ---LYLRRPLLICIgLVLVFNVTNYMLL-SYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVgrKPVYAA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 299 MKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFigmSSSVL---APYI 375
Cdd:cd17366 265 GLAGLLVLAVPAFLLMNSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNI---SVSLFggtTPLV 341
|
330 340 350
....*....|....*....|....*....|....
gi 1169138901 376 TGVLSIYTGSMKAGFYLASVFLLIGYFSLILIKE 409
Cdd:cd17366 342 ASWLVSATGNPLMPAYYLMVAAVVGLVAVLFLTE 375
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
41-333 |
1.97e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 40.08 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 41 PVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYS-KKWVLVPGFLI---SGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17334 25 PIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGlRIGVLIGAALNalgSVLKCIPLGQQPKFALLVLGQV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 117 ISGIGQGTFYGPQFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFS---WRITFFIFALLTIIVSIIM 193
Cdd:cd17334 105 LNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPKGTkkeFGAVFYGEFGFACLLLALV 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 194 LFTIKNDSKNE----NLIKRKIDIEEKKFSSSIKLLLMNRNLiVSYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGY 269
Cdd:cd17334 185 LALFPPKPKYPpsaaSARQQNSEHVILELQKSISELLRNEPF-VLLAVAFSIMMGVFAGFSSVLAQILLPFGVSQTSAGW 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1169138901 270 LSSIIALLALPGSILFSWINDR---FQKHVKI--MKFMLIFSSiFTFLIGFTNSTVWIIVGLVLYGFMG 333
Cdd:cd17334 264 LGFFGIVAGMVGGLLLGLFVDRtrmFKLIGLIilALGTVVCTF-FMLLVDRYGLPYVTLAFYLLCGLLG 331
|
|
| MFS_YxiO_like |
cd17482 |
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major ... |
273-404 |
2.11e-03 |
|
Bacillus subtilis YxiO, Listeria monocytogenes BtlA, and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis MFS-type transporter YxiO, and similar proteins including Listeria monocytogenes BtlA. The function of B. subtilis YxiO is still unknown, and L. monocytogenes BtlA is a putative secondary transporter involved in bile tolerance and general stress resistance. This family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341035 [Multi-domain] Cd Length: 362 Bit Score: 39.90 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 273 IIALLALPGSILFSWINDRFQKHVKIMKFMLIFSSIFTFLIGFTNSTVWIIVGLVLYGFMGKIamDPIIVAFVANNAPQN 352
Cdd:cd17482 232 LTQFVAFPGALLFGWLAERFGAKRAILVSLVIYILICIYAYFMLTAWDFWILAALIGLVQGGI--QALSRSLFGRLIPKG 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1169138901 353 LYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGSMKAGFYLASVFLLIGYFSL 404
Cdd:cd17482 310 KSAEFFGFYNISGKFAAIIGPLLFGLITQLTGSSRYGILSLIVLFVIGGILL 361
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
76-384 |
2.47e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.89 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 76 GYLGDMYSKKWVLVPGFLISGIFLAVTGLSEG-YLLLISawMISGIGQGTFYGPQFALSSESIPNKyRTigSAIinsgGA 154
Cdd:cd17331 56 GRFGDLFGPRAALVLSFLSSALSYLLLAFASSvPMLFLS--RLPSVFMHAMQAAQMVVTDLTDPGE-RA--AAL----GR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 155 IGLS--LGFIFSSYF--TLSLGFSWRITFFIFALLTIIVSIIMLFTIKNDSKNENLIKRKIDIEEKKFSSSIKLLLMNRN 230
Cdd:cd17331 127 LGLSygIGMVVGSFLggLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTKSKREKEAKESASPPSVFNLKEILRLLRL 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 231 LIVSYIVAFCSLYGFSVMVTW--LPYYLQTEQGIEGSIAGYLSSIIALL-ALPGSILFSWINDRFQKhVKIMKFMLIFSS 307
Cdd:cd17331 207 PGVAFLLLVKLLSGLPIGMFQsmFSLVAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLTKRFGE-RSLLKLSVALLA 285
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1169138901 308 IFTFLIGFTNSTVWIIVGLVLYGFMGKIaMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTG 384
Cdd:cd17331 286 IGYLLLAFVTTVWQLLVLLLPLVIGGSV-LYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYG 361
|
|
| MFS_SVOPL |
cd17442 |
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ... |
37-189 |
2.98e-03 |
|
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341000 [Multi-domain] Cd Length: 375 Bit Score: 39.40 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 37 AILTPvigEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWM 116
Cdd:cd17442 21 AVVSP---EIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRC 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1169138901 117 ISGIG-QGTFYGpqFALSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALLTIIV 189
Cdd:cd17442 98 MVGCGvSGHSQG--LIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIV 169
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
27-189 |
3.00e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 39.44 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 27 LGWIFIYGNRAILTPVIGEIKSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSKKWVLVPGFLISGIFLAVTGLSE 106
Cdd:cd17372 6 MGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 107 GYLLLISAWMISGIGQGTfyGPQFA-LSSESIPNKYRTIGSAIINSGGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALL 185
Cdd:cd17372 86 NYMWLIILRCLVGLGLGG--GPQLAsWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSS 163
|
....
gi 1169138901 186 TIIV 189
Cdd:cd17372 164 LLLV 167
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
13-194 |
3.07e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.53 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 13 KMTPYWIRLVIVFFLGWIFIYGNRAILTPVIGEI--------KSDYSLNNAEIGLMNSLFFLAYTIVQIPSGYLGDMYSK 84
Cdd:cd17313 231 IMPRSLLRLLLVIFFWWIAFFPFELFFTDYMGEEvyhgtsaaSSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGR 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 85 KWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSESIPNKYRtigsaiiNSGGAIGLSLGFIFS 164
Cdd:cd17313 311 KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGR-------GQGTDTGLLNLAISL 383
|
170 180 190
....*....|....*....|....*....|
gi 1169138901 165 SYFTLSLGFSWRITFFIFALLTIIVSIIML 194
Cdd:cd17313 384 AQILVSLLAGPIIDVKGYGTVFPVAAVASF 413
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
235-400 |
3.99e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 3.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 235 YIVAFCSLYGFSVMVTWLPYYLQ--TEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFL 312
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVRefNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRK-PVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 313 IGFTNSTVWIIVGLVLYGFMGkiAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAPYITGVLSIYTGsMKAGFYL 392
Cdd:cd17330 81 LGLSRNLWLLFLARFLDGLTG--GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYG-YALPFLV 157
|
....*...
gi 1169138901 393 ASVFLLIG 400
Cdd:cd17330 158 AAALALLN 165
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
83-331 |
4.20e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.07 E-value: 4.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 83 SKKWVLVPGFLISGI-FLAVTGLSEGYLLLISAWMISGIGQGTFygPQ-FALSSESIPNKYRTIGSAIINS-------GG 153
Cdd:cd17471 61 DRKPLILLALLAGALgYLLFAFLRNYWVLLLVGVVLLSLGAAAF--PQlFALAREYADRSSGRDATLFNSVlraafslAW 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 154 AIGLSLGFIFSSYFtlslGFSWriTFFIFALLTIIVSIIMLFTIKNDsknenlikrKIDIEEKKFSSSIKLLLMNRNLIV 233
Cdd:cd17471 139 VIGPPLAFLLLDVL----GFTG--LFLLAALLYLVVALLVLFLLPSV---------KPPAQKATPASSLVKAPVNRRLLL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 234 SYIVAFCSLYGFSVMVTWLPYYLQTEQGIEGSIAGYLSSIIALLALPGSILFSWINDRFQKHvKIMKFMLIFSSIFTFLI 313
Cdd:cd17471 204 LFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKR-RLLLAGFLAGVLFYLGL 282
|
250
....*....|....*...
gi 1169138901 314 GFTNSTVWIIVGLVLYGF 331
Cdd:cd17471 283 ALATSLWQLIALQLLNAI 300
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| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
58-375 |
7.11e-03 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 38.11 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 58 GLMNSLFFLAYTIVQIPSGYLGD-MYSKKWVLVPGFLISGIFLAVTGLSEGYLLLISAWMISGIGQGTFYGPQFALSSES 136
Cdd:cd17378 36 GLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEP 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 137 IPNKYRTIGSAIinsgGAIGLSLGFIFSSYFTLSLGFSWRITFFIFALLTIIVSIIMLFTIKndsknenlikrkidieek 216
Cdd:cd17378 116 VGPKWRGQVGMS----TFFFFVLGFMSLPGIAYLNGSSWRVLYFWTSIPALIYCILVYLFAR------------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 217 kfsssiKLLLMnrnLIVSYIVAFcSLYGFSVMVTWLPYYLqteqgiegsiagYLSSII-ALLALPGSILFSWINDRFQKH 295
Cdd:cd17378 174 ------RLLAV---MVIGFGIGM-VYYGIPLAVGNLKFNI------------YLSVALnALSELPAFVITAFLLDRFGRR 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 296 VKIMKFMLI--FSSIFTFLIGfTNSTVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYNFIGMSSSVLAP 373
Cdd:cd17378 232 PSLLGFTLLsgASCLLCFVLS-IGGTTSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAP 310
|
..
gi 1169138901 374 YI 375
Cdd:cd17378 311 FI 312
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
222-400 |
8.99e-03 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 37.87 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 222 IKLLLMNRNLIVSYIVAFCSlYGFSVMVTWL-PYYLQTeqGIEGSIAGYLSSIIALLALPGSILFSWINDR--FQKHVKI 298
Cdd:cd17424 177 MRFLLMPDFLVLAVSVLFLA-YGCSPPFVYLvPYALSV--GVSHQQAAFLMSILGVIDIIGNITFGWLTDRrcLKKYRYF 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 299 MKFMLIFSSIFTFL-IGFTNSTVWIIVGLVLYGFM--GKIAMDPIIVAFVANNapqNLYSTTFGLYNFIGMSSSVLAPYI 375
Cdd:cd17424 254 CYLFAVGMDGLCCLfLPILKTFPLLVPFSFTFGYFdgAYVALIPVVTSDVVGT---SSLSSALGVVYFLHAVPYLVSPPI 330
|
170 180
....*....|....*....|....*
gi 1169138901 376 TGVLSIYTGSMKAGFYLASVFLLIG 400
Cdd:cd17424 331 AGWLVDTTGTYTAAFLLSGFSMIFS 355
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
284-409 |
9.45e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1169138901 284 LFS-WINDRFQKHVKIMKFMLIFSSIFTFLIGFTNStVWIIVGLVLYGFMGKIAMDPIIVAFVANNAPQNLYSTTFGLYN 362
Cdd:cd17370 52 LFSgYLSDRTGKRKPLVILGYGLSALAKPLLALAGS-WQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHR 130
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1169138901 363 FIGMSSSVLAPYI-TGVLSIYTGSMKAGFYLASVFLLIGYFSLILIKE 409
Cdd:cd17370 131 ALDTLGAVLGPLLaALLLYLLGGNYRTIFLLAAIPALLALLILLFVVK 178
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