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Conserved domains on  [gi|1170977827|ref|WP_080550853|]
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MULTISPECIES: SE2200 family small protein [Bacillati]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SE2200_fam super family cl49035
SE2200 family small protein; Members of this staphylococcal protein family are small, ...
4-36 8.11e-09

SE2200 family small protein; Members of this staphylococcal protein family are small, typically 33 amino acids long, with the first 18 amino acids resembling a signal-anchor domain for membrane insertion. A proteomics study demonstrates significant protein expression in Staphylococcus aureus, and conservation in the genus suggests purifying selection as would be expected for a real protein. This family, broadly distributed in the genus Staphylococcus, was once described as DUF2648 by Pfam model PF10855, but at the time this model was built (April 2022), that Pfam model had been retired under suspicion of not identifying real proteins.


The actual alignment was detected with superfamily member NF040843:

Pssm-ID: 468782  Cd Length: 33  Bit Score: 44.26  E-value: 8.11e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 1170977827  4 LKKLFVAIAICTIGYSVLKRYQKHVNKIPNIEY 36
Cdd:NF040843   1 MKKLLVVLIIGGAAFVAFKRYQQHVNKAPNIEY 33
 
Name Accession Description Interval E-value
SE2200_fam NF040843
SE2200 family small protein; Members of this staphylococcal protein family are small, ...
4-36 8.11e-09

SE2200 family small protein; Members of this staphylococcal protein family are small, typically 33 amino acids long, with the first 18 amino acids resembling a signal-anchor domain for membrane insertion. A proteomics study demonstrates significant protein expression in Staphylococcus aureus, and conservation in the genus suggests purifying selection as would be expected for a real protein. This family, broadly distributed in the genus Staphylococcus, was once described as DUF2648 by Pfam model PF10855, but at the time this model was built (April 2022), that Pfam model had been retired under suspicion of not identifying real proteins.


Pssm-ID: 468782  Cd Length: 33  Bit Score: 44.26  E-value: 8.11e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 1170977827  4 LKKLFVAIAICTIGYSVLKRYQKHVNKIPNIEY 36
Cdd:NF040843   1 MKKLLVVLIIGGAAFVAFKRYQQHVNKAPNIEY 33
 
Name Accession Description Interval E-value
SE2200_fam NF040843
SE2200 family small protein; Members of this staphylococcal protein family are small, ...
4-36 8.11e-09

SE2200 family small protein; Members of this staphylococcal protein family are small, typically 33 amino acids long, with the first 18 amino acids resembling a signal-anchor domain for membrane insertion. A proteomics study demonstrates significant protein expression in Staphylococcus aureus, and conservation in the genus suggests purifying selection as would be expected for a real protein. This family, broadly distributed in the genus Staphylococcus, was once described as DUF2648 by Pfam model PF10855, but at the time this model was built (April 2022), that Pfam model had been retired under suspicion of not identifying real proteins.


Pssm-ID: 468782  Cd Length: 33  Bit Score: 44.26  E-value: 8.11e-09
                         10        20        30
                 ....*....|....*....|....*....|...
gi 1170977827  4 LKKLFVAIAICTIGYSVLKRYQKHVNKIPNIEY 36
Cdd:NF040843   1 MKKLLVVLIIGGAAFVAFKRYQQHVNKAPNIEY 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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